-- dump date 20140620_043040 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1197719000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1197719000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1197719000003 putative catalytic residues [active] 1197719000004 putative nucleotide binding site [chemical binding]; other site 1197719000005 putative aspartate binding site [chemical binding]; other site 1197719000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1197719000007 dimer interface [polypeptide binding]; other site 1197719000008 putative threonine allosteric regulatory site; other site 1197719000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1197719000010 putative threonine allosteric regulatory site; other site 1197719000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1197719000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1197719000013 homoserine kinase; Provisional; Region: PRK01212 1197719000014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1197719000015 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1197719000016 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1197719000017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719000018 catalytic residue [active] 1197719000019 hypothetical protein; Validated; Region: PRK02101 1197719000020 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1197719000021 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1197719000022 transaldolase-like protein; Provisional; Region: PTZ00411 1197719000023 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1197719000024 active site 1197719000025 dimer interface [polypeptide binding]; other site 1197719000026 catalytic residue [active] 1197719000027 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1197719000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1197719000029 MPT binding site; other site 1197719000030 trimer interface [polypeptide binding]; other site 1197719000031 hypothetical protein; Provisional; Region: PRK10659 1197719000032 hypothetical protein; Provisional; Region: PRK10236 1197719000033 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1197719000034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1197719000035 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 1197719000036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1197719000037 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1197719000038 nucleotide binding site [chemical binding]; other site 1197719000039 chaperone protein DnaJ; Provisional; Region: PRK10767 1197719000040 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1197719000041 HSP70 interaction site [polypeptide binding]; other site 1197719000042 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1197719000043 substrate binding site [polypeptide binding]; other site 1197719000044 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1197719000045 Zn binding sites [ion binding]; other site 1197719000046 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1197719000047 dimer interface [polypeptide binding]; other site 1197719000048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719000049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719000050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719000051 dimerization interface [polypeptide binding]; other site 1197719000052 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1197719000053 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1197719000054 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1197719000055 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1197719000056 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1197719000057 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1197719000058 active site 1197719000059 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1197719000060 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1197719000061 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1197719000062 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1197719000063 Helix-turn-helix domain; Region: HTH_36; pfam13730 1197719000064 fimbrial protein BcfA; Provisional; Region: PRK15187 1197719000065 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 1197719000066 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719000067 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719000068 outer membrane usher protein; Provisional; Region: PRK15193 1197719000069 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719000070 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719000071 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719000072 Fimbrial protein; Region: Fimbrial; cl01416 1197719000073 fimbrial protein BcfE; Provisional; Region: PRK15190 1197719000074 Fimbrial protein; Region: Fimbrial; cl01416 1197719000075 fimbrial chaperone BcfG; Provisional; Region: PRK15192 1197719000076 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719000077 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719000078 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1197719000079 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1197719000080 catalytic residues [active] 1197719000081 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1197719000082 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1197719000083 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 1197719000084 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1197719000085 Sulfatase; Region: Sulfatase; pfam00884 1197719000086 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1197719000087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719000088 FeS/SAM binding site; other site 1197719000089 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1197719000090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1197719000091 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1197719000092 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1197719000093 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1197719000094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719000095 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1197719000096 putative dimerization interface [polypeptide binding]; other site 1197719000097 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1197719000098 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 1197719000099 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1197719000100 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1197719000101 active site 1197719000102 Riboflavin kinase; Region: Flavokinase; smart00904 1197719000103 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1197719000104 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1197719000105 HIGH motif; other site 1197719000106 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1197719000107 active site 1197719000108 KMSKS motif; other site 1197719000109 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1197719000110 tRNA binding surface [nucleotide binding]; other site 1197719000111 anticodon binding site; other site 1197719000112 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1197719000113 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1197719000114 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1197719000115 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1197719000116 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1197719000117 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1197719000118 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1197719000119 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1197719000120 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1197719000121 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1197719000122 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 1197719000123 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1197719000124 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1197719000125 catalytic site [active] 1197719000126 subunit interface [polypeptide binding]; other site 1197719000127 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1197719000128 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1197719000129 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1197719000130 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1197719000131 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1197719000132 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1197719000133 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1197719000134 IMP binding site; other site 1197719000135 dimer interface [polypeptide binding]; other site 1197719000136 interdomain contacts; other site 1197719000137 partial ornithine binding site; other site 1197719000138 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1197719000139 carnitine operon protein CaiE; Provisional; Region: PRK13627 1197719000140 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1197719000141 putative trimer interface [polypeptide binding]; other site 1197719000142 putative metal binding site [ion binding]; other site 1197719000143 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1197719000144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1197719000145 substrate binding site [chemical binding]; other site 1197719000146 oxyanion hole (OAH) forming residues; other site 1197719000147 trimer interface [polypeptide binding]; other site 1197719000148 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1197719000149 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1197719000150 acyl-activating enzyme (AAE) consensus motif; other site 1197719000151 putative AMP binding site [chemical binding]; other site 1197719000152 putative active site [active] 1197719000153 putative CoA binding site [chemical binding]; other site 1197719000154 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1197719000155 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1197719000156 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1197719000157 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1197719000158 active site 1197719000159 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1197719000160 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1197719000161 Ligand binding site [chemical binding]; other site 1197719000162 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1197719000163 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1197719000164 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1197719000165 Ligand binding site [chemical binding]; other site 1197719000166 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1197719000167 putative oxidoreductase FixC; Provisional; Region: PRK10157 1197719000168 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1197719000169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719000170 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1197719000171 putative substrate translocation pore; other site 1197719000172 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1197719000173 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719000174 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1197719000175 Sulfatase; Region: Sulfatase; cl17466 1197719000176 Sulfatase; Region: Sulfatase; cl17466 1197719000177 Sulfatase; Region: Sulfatase; cl17466 1197719000178 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1197719000179 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1197719000180 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1197719000181 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1197719000182 TrkA-N domain; Region: TrkA_N; pfam02254 1197719000183 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1197719000184 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1197719000185 folate binding site [chemical binding]; other site 1197719000186 NADP+ binding site [chemical binding]; other site 1197719000187 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1197719000188 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1197719000189 active site 1197719000190 metal binding site [ion binding]; metal-binding site 1197719000191 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1197719000192 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1197719000193 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1197719000194 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1197719000195 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1197719000196 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1197719000197 SurA N-terminal domain; Region: SurA_N; pfam09312 1197719000198 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1197719000199 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1197719000200 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1197719000201 OstA-like protein; Region: OstA; pfam03968 1197719000202 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1197719000203 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1197719000204 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1197719000205 putative metal binding site [ion binding]; other site 1197719000206 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1197719000207 HSP70 interaction site [polypeptide binding]; other site 1197719000208 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1197719000209 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1197719000210 active site 1197719000211 ATP-dependent helicase HepA; Validated; Region: PRK04914 1197719000212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719000213 ATP binding site [chemical binding]; other site 1197719000214 putative Mg++ binding site [ion binding]; other site 1197719000215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719000216 nucleotide binding region [chemical binding]; other site 1197719000217 ATP-binding site [chemical binding]; other site 1197719000218 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1197719000219 DNA polymerase family B; Region: DNA_pol_B; pfam00136 1197719000220 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1197719000221 active site 1197719000222 metal-binding site 1197719000223 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1197719000224 active site 1197719000225 catalytic site [active] 1197719000226 substrate binding site [chemical binding]; other site 1197719000227 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1197719000228 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1197719000229 intersubunit interface [polypeptide binding]; other site 1197719000230 active site 1197719000231 Zn2+ binding site [ion binding]; other site 1197719000232 L-arabinose isomerase; Provisional; Region: PRK02929 1197719000233 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1197719000234 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1197719000235 trimer interface [polypeptide binding]; other site 1197719000236 putative substrate binding site [chemical binding]; other site 1197719000237 putative metal binding site [ion binding]; other site 1197719000238 ribulokinase; Provisional; Region: PRK04123 1197719000239 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1197719000240 N- and C-terminal domain interface [polypeptide binding]; other site 1197719000241 active site 1197719000242 MgATP binding site [chemical binding]; other site 1197719000243 catalytic site [active] 1197719000244 metal binding site [ion binding]; metal-binding site 1197719000245 carbohydrate binding site [chemical binding]; other site 1197719000246 homodimer interface [polypeptide binding]; other site 1197719000247 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1197719000248 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1197719000249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719000250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719000251 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1197719000252 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1197719000253 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1197719000254 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1197719000255 Walker A/P-loop; other site 1197719000256 ATP binding site [chemical binding]; other site 1197719000257 Q-loop/lid; other site 1197719000258 ABC transporter signature motif; other site 1197719000259 Walker B; other site 1197719000260 D-loop; other site 1197719000261 H-loop/switch region; other site 1197719000262 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1197719000263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719000264 dimer interface [polypeptide binding]; other site 1197719000265 conserved gate region; other site 1197719000266 putative PBP binding loops; other site 1197719000267 ABC-ATPase subunit interface; other site 1197719000268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719000269 dimer interface [polypeptide binding]; other site 1197719000270 conserved gate region; other site 1197719000271 putative PBP binding loops; other site 1197719000272 ABC-ATPase subunit interface; other site 1197719000273 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1197719000274 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1197719000275 transcriptional regulator SgrR; Provisional; Region: PRK13626 1197719000276 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1197719000277 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1197719000278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719000279 sugar efflux transporter; Region: 2A0120; TIGR00899 1197719000280 putative substrate translocation pore; other site 1197719000281 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1197719000282 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1197719000283 substrate binding site [chemical binding]; other site 1197719000284 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1197719000285 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1197719000286 substrate binding site [chemical binding]; other site 1197719000287 ligand binding site [chemical binding]; other site 1197719000288 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1197719000289 tartrate dehydrogenase; Region: TTC; TIGR02089 1197719000290 2-isopropylmalate synthase; Validated; Region: PRK00915 1197719000291 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1197719000292 active site 1197719000293 catalytic residues [active] 1197719000294 metal binding site [ion binding]; metal-binding site 1197719000295 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1197719000296 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1197719000297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719000298 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1197719000299 putative substrate binding pocket [chemical binding]; other site 1197719000300 putative dimerization interface [polypeptide binding]; other site 1197719000301 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1197719000302 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1197719000303 PYR/PP interface [polypeptide binding]; other site 1197719000304 dimer interface [polypeptide binding]; other site 1197719000305 TPP binding site [chemical binding]; other site 1197719000306 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1197719000307 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1197719000308 TPP-binding site [chemical binding]; other site 1197719000309 dimer interface [polypeptide binding]; other site 1197719000310 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1197719000311 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1197719000312 putative valine binding site [chemical binding]; other site 1197719000313 dimer interface [polypeptide binding]; other site 1197719000314 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1197719000315 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1197719000316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719000317 DNA binding site [nucleotide binding] 1197719000318 domain linker motif; other site 1197719000319 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1197719000320 dimerization interface [polypeptide binding]; other site 1197719000321 ligand binding site [chemical binding]; other site 1197719000322 mraZ protein; Region: TIGR00242 1197719000323 MraZ protein; Region: MraZ; pfam02381 1197719000324 MraZ protein; Region: MraZ; pfam02381 1197719000325 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1197719000326 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1197719000327 cell division protein FtsL; Provisional; Region: PRK10772 1197719000328 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1197719000329 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1197719000330 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1197719000331 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1197719000332 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1197719000333 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1197719000334 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1197719000335 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1197719000336 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1197719000337 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1197719000338 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1197719000339 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1197719000340 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1197719000341 Mg++ binding site [ion binding]; other site 1197719000342 putative catalytic motif [active] 1197719000343 putative substrate binding site [chemical binding]; other site 1197719000344 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1197719000345 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1197719000346 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1197719000347 cell division protein FtsW; Provisional; Region: PRK10774 1197719000348 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1197719000349 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1197719000350 active site 1197719000351 homodimer interface [polypeptide binding]; other site 1197719000352 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1197719000353 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1197719000354 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1197719000355 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1197719000356 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1197719000357 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1197719000358 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1197719000359 cell division protein FtsQ; Provisional; Region: PRK10775 1197719000360 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1197719000361 Cell division protein FtsQ; Region: FtsQ; pfam03799 1197719000362 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1197719000363 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1197719000364 Cell division protein FtsA; Region: FtsA; pfam14450 1197719000365 cell division protein FtsZ; Validated; Region: PRK09330 1197719000366 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1197719000367 nucleotide binding site [chemical binding]; other site 1197719000368 SulA interaction site; other site 1197719000369 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1197719000370 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1197719000371 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1197719000372 SecA regulator SecM; Provisional; Region: PRK02943 1197719000373 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1197719000374 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1197719000375 SEC-C motif; Region: SEC-C; pfam02810 1197719000376 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1197719000377 active site 1197719000378 8-oxo-dGMP binding site [chemical binding]; other site 1197719000379 nudix motif; other site 1197719000380 metal binding site [ion binding]; metal-binding site 1197719000381 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719000382 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719000383 active site 1197719000384 catalytic tetrad [active] 1197719000385 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719000386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719000387 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1197719000388 putative effector binding pocket; other site 1197719000389 putative dimerization interface [polypeptide binding]; other site 1197719000390 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1197719000391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1197719000392 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1197719000393 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1197719000394 CoA-binding site [chemical binding]; other site 1197719000395 ATP-binding [chemical binding]; other site 1197719000396 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1197719000397 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1197719000398 active site 1197719000399 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1197719000400 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1197719000401 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1197719000402 hypothetical protein; Provisional; Region: PRK10436 1197719000403 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1197719000404 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1197719000405 Walker A motif; other site 1197719000406 ATP binding site [chemical binding]; other site 1197719000407 Walker B motif; other site 1197719000408 putative major pilin subunit; Provisional; Region: PRK10574 1197719000409 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1197719000410 Pilin (bacterial filament); Region: Pilin; pfam00114 1197719000411 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1197719000412 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1197719000413 dimerization interface [polypeptide binding]; other site 1197719000414 active site 1197719000415 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1197719000416 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1197719000417 amidase catalytic site [active] 1197719000418 substrate binding site [chemical binding]; other site 1197719000419 Zn binding residues [ion binding]; other site 1197719000420 regulatory protein AmpE; Provisional; Region: PRK10987 1197719000421 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1197719000422 active site 1197719000423 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1197719000424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719000425 putative substrate translocation pore; other site 1197719000426 aromatic amino acid transporter; Provisional; Region: PRK10238 1197719000427 Protein of unknown function (DUF796); Region: DUF796; cl01226 1197719000428 S-type Pyocin; Region: Pyocin_S; pfam06958 1197719000429 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1197719000430 active site 1197719000431 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1197719000432 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1197719000433 active site 1197719000434 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1197719000435 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1197719000436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719000437 DNA-binding site [nucleotide binding]; DNA binding site 1197719000438 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1197719000439 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1197719000440 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1197719000441 dimer interface [polypeptide binding]; other site 1197719000442 TPP-binding site [chemical binding]; other site 1197719000443 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1197719000444 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1197719000445 E3 interaction surface; other site 1197719000446 lipoyl attachment site [posttranslational modification]; other site 1197719000447 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1197719000448 E3 interaction surface; other site 1197719000449 lipoyl attachment site [posttranslational modification]; other site 1197719000450 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1197719000451 E3 interaction surface; other site 1197719000452 lipoyl attachment site [posttranslational modification]; other site 1197719000453 e3 binding domain; Region: E3_binding; pfam02817 1197719000454 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1197719000455 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1197719000456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1197719000457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719000458 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1197719000459 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1197719000460 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1197719000461 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1197719000462 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1197719000463 substrate binding site [chemical binding]; other site 1197719000464 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1197719000465 substrate binding site [chemical binding]; other site 1197719000466 ligand binding site [chemical binding]; other site 1197719000467 hypothetical protein; Provisional; Region: PRK05248 1197719000468 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 1197719000469 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719000470 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719000471 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1197719000472 spermidine synthase; Provisional; Region: PRK00811 1197719000473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719000474 S-adenosylmethionine binding site [chemical binding]; other site 1197719000475 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1197719000476 multicopper oxidase; Provisional; Region: PRK10965 1197719000477 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1197719000478 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1197719000479 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1197719000480 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1197719000481 Trp docking motif [polypeptide binding]; other site 1197719000482 putative active site [active] 1197719000483 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719000484 active site 1197719000485 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1197719000486 active site clefts [active] 1197719000487 zinc binding site [ion binding]; other site 1197719000488 dimer interface [polypeptide binding]; other site 1197719000489 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1197719000490 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1197719000491 Walker A/P-loop; other site 1197719000492 ATP binding site [chemical binding]; other site 1197719000493 Q-loop/lid; other site 1197719000494 ABC transporter signature motif; other site 1197719000495 Walker B; other site 1197719000496 D-loop; other site 1197719000497 H-loop/switch region; other site 1197719000498 inner membrane transport permease; Provisional; Region: PRK15066 1197719000499 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1197719000500 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1197719000501 active pocket/dimerization site; other site 1197719000502 active site 1197719000503 phosphorylation site [posttranslational modification] 1197719000504 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1197719000505 putative active site [active] 1197719000506 putative metal binding site [ion binding]; other site 1197719000507 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1197719000508 tetramerization interface [polypeptide binding]; other site 1197719000509 active site 1197719000510 hypothetical protein; Provisional; Region: PRK09956 1197719000511 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719000512 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1197719000513 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1197719000514 active site 1197719000515 ATP-binding site [chemical binding]; other site 1197719000516 pantoate-binding site; other site 1197719000517 HXXH motif; other site 1197719000518 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1197719000519 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1197719000520 oligomerization interface [polypeptide binding]; other site 1197719000521 active site 1197719000522 metal binding site [ion binding]; metal-binding site 1197719000523 Fimbrial protein; Region: Fimbrial; cl01416 1197719000524 Fimbrial protein; Region: Fimbrial; cl01416 1197719000525 putative fimbrial protein StaE; Provisional; Region: PRK15263 1197719000526 Fimbrial protein; Region: Fimbrial; cl01416 1197719000527 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1197719000528 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719000529 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719000530 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719000531 putative chaperone protein EcpD; Provisional; Region: PRK09926 1197719000532 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719000533 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719000534 Fimbrial protein; Region: Fimbrial; cl01416 1197719000535 Fimbrial protein; Region: Fimbrial; cl01416 1197719000536 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1197719000537 catalytic center binding site [active] 1197719000538 ATP binding site [chemical binding]; other site 1197719000539 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1197719000540 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1197719000541 active site 1197719000542 NTP binding site [chemical binding]; other site 1197719000543 metal binding triad [ion binding]; metal-binding site 1197719000544 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1197719000545 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1197719000546 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1197719000547 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1197719000548 active site 1197719000549 nucleotide binding site [chemical binding]; other site 1197719000550 HIGH motif; other site 1197719000551 KMSKS motif; other site 1197719000552 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1197719000553 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1197719000554 2'-5' RNA ligase; Provisional; Region: PRK15124 1197719000555 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1197719000556 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1197719000557 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1197719000558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719000559 ATP binding site [chemical binding]; other site 1197719000560 putative Mg++ binding site [ion binding]; other site 1197719000561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719000562 nucleotide binding region [chemical binding]; other site 1197719000563 ATP-binding site [chemical binding]; other site 1197719000564 Helicase associated domain (HA2); Region: HA2; pfam04408 1197719000565 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1197719000566 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1197719000567 Transglycosylase; Region: Transgly; pfam00912 1197719000568 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1197719000569 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1197719000570 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1197719000571 N-terminal plug; other site 1197719000572 ligand-binding site [chemical binding]; other site 1197719000573 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1197719000574 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1197719000575 Walker A/P-loop; other site 1197719000576 ATP binding site [chemical binding]; other site 1197719000577 Q-loop/lid; other site 1197719000578 ABC transporter signature motif; other site 1197719000579 Walker B; other site 1197719000580 D-loop; other site 1197719000581 H-loop/switch region; other site 1197719000582 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1197719000583 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1197719000584 siderophore binding site; other site 1197719000585 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1197719000586 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719000587 ABC-ATPase subunit interface; other site 1197719000588 dimer interface [polypeptide binding]; other site 1197719000589 putative PBP binding regions; other site 1197719000590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719000591 ABC-ATPase subunit interface; other site 1197719000592 dimer interface [polypeptide binding]; other site 1197719000593 putative PBP binding regions; other site 1197719000594 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1197719000595 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1197719000596 inhibitor-cofactor binding pocket; inhibition site 1197719000597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719000598 catalytic residue [active] 1197719000599 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1197719000600 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1197719000601 Cl- selectivity filter; other site 1197719000602 Cl- binding residues [ion binding]; other site 1197719000603 pore gating glutamate residue; other site 1197719000604 dimer interface [polypeptide binding]; other site 1197719000605 H+/Cl- coupling transport residue; other site 1197719000606 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1197719000607 hypothetical protein; Provisional; Region: PRK10578 1197719000608 UPF0126 domain; Region: UPF0126; pfam03458 1197719000609 UPF0126 domain; Region: UPF0126; pfam03458 1197719000610 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1197719000611 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1197719000612 cobalamin binding residues [chemical binding]; other site 1197719000613 putative BtuC binding residues; other site 1197719000614 dimer interface [polypeptide binding]; other site 1197719000615 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1197719000616 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1197719000617 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1197719000618 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1197719000619 Zn2+ binding site [ion binding]; other site 1197719000620 Mg2+ binding site [ion binding]; other site 1197719000621 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1197719000622 serine endoprotease; Provisional; Region: PRK10942 1197719000623 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1197719000624 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1197719000625 protein binding site [polypeptide binding]; other site 1197719000626 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1197719000627 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1197719000628 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1197719000629 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1197719000630 Viral enhancin protein; Region: Enhancin; pfam03272 1197719000631 Peptidase M60-like family; Region: M60-like; pfam13402 1197719000632 hypothetical protein; Provisional; Region: PRK13677 1197719000633 shikimate transporter; Provisional; Region: PRK09952 1197719000634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719000635 putative substrate translocation pore; other site 1197719000636 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1197719000637 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1197719000638 trimer interface [polypeptide binding]; other site 1197719000639 active site 1197719000640 substrate binding site [chemical binding]; other site 1197719000641 CoA binding site [chemical binding]; other site 1197719000642 PII uridylyl-transferase; Provisional; Region: PRK05007 1197719000643 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1197719000644 metal binding triad; other site 1197719000645 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1197719000646 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1197719000647 Zn2+ binding site [ion binding]; other site 1197719000648 Mg2+ binding site [ion binding]; other site 1197719000649 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1197719000650 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1197719000651 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1197719000652 active site 1197719000653 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1197719000654 rRNA interaction site [nucleotide binding]; other site 1197719000655 S8 interaction site; other site 1197719000656 putative laminin-1 binding site; other site 1197719000657 elongation factor Ts; Provisional; Region: tsf; PRK09377 1197719000658 UBA/TS-N domain; Region: UBA; pfam00627 1197719000659 Elongation factor TS; Region: EF_TS; pfam00889 1197719000660 Elongation factor TS; Region: EF_TS; pfam00889 1197719000661 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1197719000662 putative nucleotide binding site [chemical binding]; other site 1197719000663 uridine monophosphate binding site [chemical binding]; other site 1197719000664 homohexameric interface [polypeptide binding]; other site 1197719000665 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1197719000666 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1197719000667 hinge region; other site 1197719000668 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1197719000669 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1197719000670 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1197719000671 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1197719000672 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1197719000673 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1197719000674 catalytic residue [active] 1197719000675 putative FPP diphosphate binding site; other site 1197719000676 putative FPP binding hydrophobic cleft; other site 1197719000677 dimer interface [polypeptide binding]; other site 1197719000678 putative IPP diphosphate binding site; other site 1197719000679 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1197719000680 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1197719000681 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1197719000682 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1197719000683 active site 1197719000684 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1197719000685 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1197719000686 protein binding site [polypeptide binding]; other site 1197719000687 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1197719000688 putative substrate binding region [chemical binding]; other site 1197719000689 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1197719000690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1197719000691 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1197719000692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1197719000693 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1197719000694 Surface antigen; Region: Bac_surface_Ag; pfam01103 1197719000695 periplasmic chaperone; Provisional; Region: PRK10780 1197719000696 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1197719000697 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1197719000698 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1197719000699 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1197719000700 trimer interface [polypeptide binding]; other site 1197719000701 active site 1197719000702 UDP-GlcNAc binding site [chemical binding]; other site 1197719000703 lipid binding site [chemical binding]; lipid-binding site 1197719000704 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1197719000705 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1197719000706 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1197719000707 active site 1197719000708 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1197719000709 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1197719000710 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1197719000711 RNA/DNA hybrid binding site [nucleotide binding]; other site 1197719000712 active site 1197719000713 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1197719000714 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1197719000715 putative active site [active] 1197719000716 putative PHP Thumb interface [polypeptide binding]; other site 1197719000717 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1197719000718 generic binding surface II; other site 1197719000719 generic binding surface I; other site 1197719000720 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1197719000721 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1197719000722 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1197719000723 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1197719000724 putative sugar binding site [chemical binding]; other site 1197719000725 catalytic residues [active] 1197719000726 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 1197719000727 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1197719000728 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1197719000729 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1197719000730 homodimer interface [polypeptide binding]; other site 1197719000731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719000732 catalytic residue [active] 1197719000733 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1197719000734 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1197719000735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1197719000736 putative metal binding site [ion binding]; other site 1197719000737 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1197719000738 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1197719000739 Ligand Binding Site [chemical binding]; other site 1197719000740 TilS substrate binding domain; Region: TilS; pfam09179 1197719000741 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1197719000742 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1197719000743 hypothetical protein; Provisional; Region: PRK04964 1197719000744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1197719000745 hypothetical protein; Provisional; Region: PRK09256 1197719000746 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1197719000747 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1197719000748 NlpE N-terminal domain; Region: NlpE; pfam04170 1197719000749 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1197719000750 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1197719000751 dimer interface [polypeptide binding]; other site 1197719000752 motif 1; other site 1197719000753 active site 1197719000754 motif 2; other site 1197719000755 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1197719000756 putative deacylase active site [active] 1197719000757 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1197719000758 active site 1197719000759 motif 3; other site 1197719000760 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1197719000761 anticodon binding site; other site 1197719000762 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1197719000763 homodimer interaction site [polypeptide binding]; other site 1197719000764 cofactor binding site; other site 1197719000765 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1197719000766 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1197719000767 lipoprotein, YaeC family; Region: TIGR00363 1197719000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719000769 dimer interface [polypeptide binding]; other site 1197719000770 conserved gate region; other site 1197719000771 ABC-ATPase subunit interface; other site 1197719000772 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1197719000773 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1197719000774 Walker A/P-loop; other site 1197719000775 ATP binding site [chemical binding]; other site 1197719000776 Q-loop/lid; other site 1197719000777 ABC transporter signature motif; other site 1197719000778 Walker B; other site 1197719000779 D-loop; other site 1197719000780 H-loop/switch region; other site 1197719000781 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1197719000782 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1197719000783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719000784 active site 1197719000785 motif I; other site 1197719000786 motif II; other site 1197719000787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719000788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719000789 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1197719000790 putative effector binding pocket; other site 1197719000791 dimerization interface [polypeptide binding]; other site 1197719000792 hypothetical protein; Provisional; Region: PRK05421 1197719000793 putative catalytic site [active] 1197719000794 putative metal binding site [ion binding]; other site 1197719000795 putative phosphate binding site [ion binding]; other site 1197719000796 putative catalytic site [active] 1197719000797 putative phosphate binding site [ion binding]; other site 1197719000798 putative metal binding site [ion binding]; other site 1197719000799 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1197719000800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719000801 S-adenosylmethionine binding site [chemical binding]; other site 1197719000802 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1197719000803 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719000804 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719000805 catalytic residue [active] 1197719000806 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1197719000807 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719000808 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1197719000809 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719000810 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1197719000811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719000812 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1197719000813 RNA/DNA hybrid binding site [nucleotide binding]; other site 1197719000814 active site 1197719000815 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1197719000816 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1197719000817 active site 1197719000818 catalytic site [active] 1197719000819 substrate binding site [chemical binding]; other site 1197719000820 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1197719000821 Autotransporter beta-domain; Region: Autotransporter; smart00869 1197719000822 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1197719000823 dimer interface [polypeptide binding]; other site 1197719000824 C-N hydrolase family amidase; Provisional; Region: PRK10438 1197719000825 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1197719000826 putative active site [active] 1197719000827 catalytic triad [active] 1197719000828 dimer interface [polypeptide binding]; other site 1197719000829 multimer interface [polypeptide binding]; other site 1197719000830 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1197719000831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1197719000832 active site 1197719000833 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1197719000834 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1197719000835 dimer interface [polypeptide binding]; other site 1197719000836 active site 1197719000837 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1197719000838 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1197719000839 putative active site [active] 1197719000840 putative dimer interface [polypeptide binding]; other site 1197719000841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1197719000842 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1197719000843 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1197719000844 active site 1197719000845 DNA polymerase IV; Validated; Region: PRK02406 1197719000846 DNA binding site [nucleotide binding] 1197719000847 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1197719000848 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1197719000849 metal binding site [ion binding]; metal-binding site 1197719000850 dimer interface [polypeptide binding]; other site 1197719000851 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719000852 active site 1197719000853 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1197719000854 Transcriptional regulator Crl; Region: Crl; cl11653 1197719000855 gamma-glutamyl kinase; Provisional; Region: PRK05429 1197719000856 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1197719000857 nucleotide binding site [chemical binding]; other site 1197719000858 homotetrameric interface [polypeptide binding]; other site 1197719000859 putative phosphate binding site [ion binding]; other site 1197719000860 putative allosteric binding site; other site 1197719000861 PUA domain; Region: PUA; pfam01472 1197719000862 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1197719000863 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1197719000864 putative catalytic cysteine [active] 1197719000865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719000866 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1197719000867 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719000868 catalytic residue [active] 1197719000869 Toxin-coregulated pilus subunit TcpA; Region: TcpA; pfam05946 1197719000870 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1197719000871 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1197719000872 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1197719000873 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1197719000874 Type II/IV secretion system protein; Region: T2SE; pfam00437 1197719000875 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1197719000876 Walker A motif; other site 1197719000877 ATP binding site [chemical binding]; other site 1197719000878 Walker B motif; other site 1197719000879 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1197719000880 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1197719000881 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1197719000882 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1197719000883 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1197719000884 Fimbrial protein; Region: Fimbrial; pfam00419 1197719000885 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719000886 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719000887 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 1197719000888 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719000889 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719000890 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719000891 transcriptional activator SprB; Provisional; Region: PRK15320 1197719000892 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1197719000893 DNA binding residues [nucleotide binding] 1197719000894 negative regulator GrlR; Provisional; Region: PRK14051 1197719000895 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1197719000896 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1197719000897 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1197719000898 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719000899 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719000900 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1197719000901 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1197719000902 metal-binding site [ion binding] 1197719000903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1197719000904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719000905 motif II; other site 1197719000906 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1197719000907 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1197719000908 DNA binding residues [nucleotide binding] 1197719000909 dimer interface [polypeptide binding]; other site 1197719000910 copper binding site [ion binding]; other site 1197719000911 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1197719000912 metal-binding site [ion binding] 1197719000913 putative sialic acid transporter; Region: 2A0112; TIGR00891 1197719000914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719000915 putative substrate translocation pore; other site 1197719000916 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1197719000917 DNA methylase; Region: N6_N4_Mtase; cl17433 1197719000918 DNA methylase; Region: N6_N4_Mtase; pfam01555 1197719000919 DNA methylase; Region: N6_N4_Mtase; cl17433 1197719000920 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1197719000921 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1197719000922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1197719000923 VRR-NUC domain; Region: VRR_NUC; pfam08774 1197719000924 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1197719000925 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1197719000926 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1197719000927 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1197719000928 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1197719000929 hypothetical protein; Provisional; Region: PRK09929 1197719000930 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1197719000931 Propionate catabolism activator; Region: PrpR_N; pfam06506 1197719000932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719000933 Walker A motif; other site 1197719000934 ATP binding site [chemical binding]; other site 1197719000935 Walker B motif; other site 1197719000936 arginine finger; other site 1197719000937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1197719000938 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1197719000939 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1197719000940 tetramer interface [polypeptide binding]; other site 1197719000941 active site 1197719000942 Mg2+/Mn2+ binding site [ion binding]; other site 1197719000943 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1197719000944 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1197719000945 dimer interface [polypeptide binding]; other site 1197719000946 active site 1197719000947 citrylCoA binding site [chemical binding]; other site 1197719000948 oxalacetate/citrate binding site [chemical binding]; other site 1197719000949 coenzyme A binding site [chemical binding]; other site 1197719000950 catalytic triad [active] 1197719000951 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1197719000952 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1197719000953 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1197719000954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1197719000955 acyl-activating enzyme (AAE) consensus motif; other site 1197719000956 AMP binding site [chemical binding]; other site 1197719000957 active site 1197719000958 CoA binding site [chemical binding]; other site 1197719000959 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1197719000960 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1197719000961 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1197719000962 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1197719000963 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1197719000964 hypothetical protein; Provisional; Region: PRK12378 1197719000965 lac repressor; Reviewed; Region: lacI; PRK09526 1197719000966 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719000967 DNA binding site [nucleotide binding] 1197719000968 domain linker motif; other site 1197719000969 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1197719000970 ligand binding site [chemical binding]; other site 1197719000971 dimerization interface (open form) [polypeptide binding]; other site 1197719000972 dimerization interface (closed form) [polypeptide binding]; other site 1197719000973 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1197719000974 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1197719000975 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1197719000976 dimer interface [polypeptide binding]; other site 1197719000977 active site 1197719000978 Schiff base residues; other site 1197719000979 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1197719000980 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1197719000981 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1197719000982 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1197719000983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1197719000984 ligand binding site [chemical binding]; other site 1197719000985 flexible hinge region; other site 1197719000986 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1197719000987 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1197719000988 microcin B17 transporter; Reviewed; Region: PRK11098 1197719000989 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1197719000990 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1197719000991 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1197719000992 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1197719000993 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1197719000994 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1197719000995 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1197719000996 drug efflux system protein MdtG; Provisional; Region: PRK09874 1197719000997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719000998 putative substrate translocation pore; other site 1197719000999 anti-RssB factor; Provisional; Region: PRK10244 1197719001000 hypothetical protein; Provisional; Region: PRK11505 1197719001001 psiF repeat; Region: PsiF_repeat; pfam07769 1197719001002 psiF repeat; Region: PsiF_repeat; pfam07769 1197719001003 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1197719001004 MASE2 domain; Region: MASE2; pfam05230 1197719001005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719001006 metal binding site [ion binding]; metal-binding site 1197719001007 active site 1197719001008 I-site; other site 1197719001009 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1197719001010 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1197719001011 hypothetical protein; Validated; Region: PRK00124 1197719001012 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1197719001013 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1197719001014 ADP binding site [chemical binding]; other site 1197719001015 magnesium binding site [ion binding]; other site 1197719001016 putative shikimate binding site; other site 1197719001017 hypothetical protein; Provisional; Region: PRK10380 1197719001018 hypothetical protein; Provisional; Region: PRK10481 1197719001019 hypothetical protein; Provisional; Region: PRK10579 1197719001020 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1197719001021 fructokinase; Reviewed; Region: PRK09557 1197719001022 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1197719001023 nucleotide binding site [chemical binding]; other site 1197719001024 MFS transport protein AraJ; Provisional; Region: PRK10091 1197719001025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001026 putative substrate translocation pore; other site 1197719001027 exonuclease subunit SbcC; Provisional; Region: PRK10246 1197719001028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719001029 Walker A/P-loop; other site 1197719001030 ATP binding site [chemical binding]; other site 1197719001031 Q-loop/lid; other site 1197719001032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719001033 ABC transporter signature motif; other site 1197719001034 Walker B; other site 1197719001035 D-loop; other site 1197719001036 H-loop/switch region; other site 1197719001037 exonuclease subunit SbcD; Provisional; Region: PRK10966 1197719001038 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1197719001039 active site 1197719001040 metal binding site [ion binding]; metal-binding site 1197719001041 DNA binding site [nucleotide binding] 1197719001042 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1197719001043 transcriptional regulator PhoB; Provisional; Region: PRK10161 1197719001044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719001045 active site 1197719001046 phosphorylation site [posttranslational modification] 1197719001047 intermolecular recognition site; other site 1197719001048 dimerization interface [polypeptide binding]; other site 1197719001049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719001050 DNA binding site [nucleotide binding] 1197719001051 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1197719001052 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1197719001053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719001054 putative active site [active] 1197719001055 heme pocket [chemical binding]; other site 1197719001056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719001057 dimer interface [polypeptide binding]; other site 1197719001058 phosphorylation site [posttranslational modification] 1197719001059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719001060 ATP binding site [chemical binding]; other site 1197719001061 Mg2+ binding site [ion binding]; other site 1197719001062 G-X-G motif; other site 1197719001063 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1197719001064 putative proline-specific permease; Provisional; Region: proY; PRK10580 1197719001065 maltodextrin glucosidase; Provisional; Region: PRK10785 1197719001066 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1197719001067 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1197719001068 active site 1197719001069 homodimer interface [polypeptide binding]; other site 1197719001070 catalytic site [active] 1197719001071 peroxidase; Provisional; Region: PRK15000 1197719001072 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1197719001073 dimer interface [polypeptide binding]; other site 1197719001074 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1197719001075 catalytic triad [active] 1197719001076 peroxidatic and resolving cysteines [active] 1197719001077 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1197719001078 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1197719001079 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1197719001080 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1197719001081 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1197719001082 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1197719001083 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1197719001084 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1197719001085 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1197719001086 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1197719001087 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1197719001088 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1197719001089 Protein export membrane protein; Region: SecD_SecF; pfam02355 1197719001090 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1197719001091 active site 1197719001092 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1197719001093 hypothetical protein; Provisional; Region: PRK11530 1197719001094 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1197719001095 ATP cone domain; Region: ATP-cone; pfam03477 1197719001096 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1197719001097 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1197719001098 catalytic motif [active] 1197719001099 Zn binding site [ion binding]; other site 1197719001100 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1197719001101 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1197719001102 homopentamer interface [polypeptide binding]; other site 1197719001103 active site 1197719001104 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1197719001105 putative RNA binding site [nucleotide binding]; other site 1197719001106 thiamine monophosphate kinase; Provisional; Region: PRK05731 1197719001107 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1197719001108 ATP binding site [chemical binding]; other site 1197719001109 dimerization interface [polypeptide binding]; other site 1197719001110 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1197719001111 tetramer interfaces [polypeptide binding]; other site 1197719001112 binuclear metal-binding site [ion binding]; other site 1197719001113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719001114 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719001115 active site 1197719001116 catalytic tetrad [active] 1197719001117 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1197719001118 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1197719001119 TPP-binding site; other site 1197719001120 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1197719001121 PYR/PP interface [polypeptide binding]; other site 1197719001122 dimer interface [polypeptide binding]; other site 1197719001123 TPP binding site [chemical binding]; other site 1197719001124 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1197719001125 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1197719001126 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1197719001127 substrate binding pocket [chemical binding]; other site 1197719001128 chain length determination region; other site 1197719001129 substrate-Mg2+ binding site; other site 1197719001130 catalytic residues [active] 1197719001131 aspartate-rich region 1; other site 1197719001132 active site lid residues [active] 1197719001133 aspartate-rich region 2; other site 1197719001134 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1197719001135 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1197719001136 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1197719001137 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1197719001138 Ligand Binding Site [chemical binding]; other site 1197719001139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1197719001140 active site residue [active] 1197719001141 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1197719001142 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1197719001143 conserved cys residue [active] 1197719001144 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1197719001145 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1197719001146 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1197719001147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1197719001148 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1197719001149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1197719001151 putative substrate translocation pore; other site 1197719001152 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1197719001153 UbiA prenyltransferase family; Region: UbiA; pfam01040 1197719001154 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1197719001155 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1197719001156 Subunit I/III interface [polypeptide binding]; other site 1197719001157 Subunit III/IV interface [polypeptide binding]; other site 1197719001158 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1197719001159 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1197719001160 D-pathway; other site 1197719001161 Putative ubiquinol binding site [chemical binding]; other site 1197719001162 Low-spin heme (heme b) binding site [chemical binding]; other site 1197719001163 Putative water exit pathway; other site 1197719001164 Binuclear center (heme o3/CuB) [ion binding]; other site 1197719001165 K-pathway; other site 1197719001166 Putative proton exit pathway; other site 1197719001167 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1197719001168 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1197719001169 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1197719001170 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1197719001171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001172 putative substrate translocation pore; other site 1197719001173 hypothetical protein; Provisional; Region: PRK11627 1197719001174 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1197719001175 transcriptional regulator BolA; Provisional; Region: PRK11628 1197719001176 trigger factor; Provisional; Region: tig; PRK01490 1197719001177 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1197719001178 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1197719001179 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1197719001180 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1197719001181 oligomer interface [polypeptide binding]; other site 1197719001182 active site residues [active] 1197719001183 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1197719001184 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1197719001185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719001186 Walker A motif; other site 1197719001187 ATP binding site [chemical binding]; other site 1197719001188 Walker B motif; other site 1197719001189 Iron permease FTR1 family; Region: FTR1; cl00475 1197719001190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1197719001191 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1197719001192 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1197719001193 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1197719001194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719001195 Walker A motif; other site 1197719001196 ATP binding site [chemical binding]; other site 1197719001197 Walker B motif; other site 1197719001198 arginine finger; other site 1197719001199 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1197719001200 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1197719001201 IHF dimer interface [polypeptide binding]; other site 1197719001202 IHF - DNA interface [nucleotide binding]; other site 1197719001203 periplasmic folding chaperone; Provisional; Region: PRK10788 1197719001204 SurA N-terminal domain; Region: SurA_N_3; cl07813 1197719001205 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1197719001206 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1197719001207 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1197719001208 active site 1197719001209 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1197719001210 Ligand Binding Site [chemical binding]; other site 1197719001211 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1197719001212 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1197719001213 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1197719001214 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1197719001215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719001216 active site 1197719001217 motif I; other site 1197719001218 motif II; other site 1197719001219 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1197719001220 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1197719001221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1197719001222 catalytic residue [active] 1197719001223 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1197719001224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1197719001225 putative DNA binding site [nucleotide binding]; other site 1197719001226 putative Zn2+ binding site [ion binding]; other site 1197719001227 AsnC family; Region: AsnC_trans_reg; pfam01037 1197719001228 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1197719001229 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1197719001230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719001231 Walker A/P-loop; other site 1197719001232 ATP binding site [chemical binding]; other site 1197719001233 Q-loop/lid; other site 1197719001234 ABC transporter signature motif; other site 1197719001235 Walker B; other site 1197719001236 D-loop; other site 1197719001237 H-loop/switch region; other site 1197719001238 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1197719001239 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1197719001240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719001241 Walker A/P-loop; other site 1197719001242 ATP binding site [chemical binding]; other site 1197719001243 Q-loop/lid; other site 1197719001244 ABC transporter signature motif; other site 1197719001245 Walker B; other site 1197719001246 D-loop; other site 1197719001247 H-loop/switch region; other site 1197719001248 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1197719001249 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1197719001250 ammonium transporter; Provisional; Region: PRK10666 1197719001251 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1197719001252 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1197719001253 active site 1197719001254 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1197719001255 catalytic triad [active] 1197719001256 dimer interface [polypeptide binding]; other site 1197719001257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1197719001258 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1197719001259 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1197719001260 DNA binding site [nucleotide binding] 1197719001261 active site 1197719001262 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1197719001263 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1197719001264 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719001265 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1197719001266 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1197719001267 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1197719001268 maltose O-acetyltransferase; Provisional; Region: PRK10092 1197719001269 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1197719001270 active site 1197719001271 substrate binding site [chemical binding]; other site 1197719001272 trimer interface [polypeptide binding]; other site 1197719001273 CoA binding site [chemical binding]; other site 1197719001274 gene expression modulator; Provisional; Region: PRK10945 1197719001275 Hha toxicity attenuator; Provisional; Region: PRK10667 1197719001276 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1197719001277 Protein export membrane protein; Region: SecD_SecF; cl14618 1197719001278 Protein export membrane protein; Region: SecD_SecF; cl14618 1197719001279 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1197719001280 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719001281 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1197719001282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719001283 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1197719001284 hypothetical protein; Provisional; Region: PRK11281 1197719001285 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1197719001286 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1197719001287 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1197719001288 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719001289 hypothetical protein; Provisional; Region: PRK11038 1197719001290 primosomal replication protein N''; Provisional; Region: PRK10093 1197719001291 hypothetical protein; Provisional; Region: PRK10527 1197719001292 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719001293 active site 1197719001294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719001295 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1197719001296 Walker A motif; other site 1197719001297 ATP binding site [chemical binding]; other site 1197719001298 Walker B motif; other site 1197719001299 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1197719001300 arginine finger; other site 1197719001301 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1197719001302 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1197719001303 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1197719001304 hypothetical protein; Validated; Region: PRK00153 1197719001305 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 1197719001306 RecR protein; Region: RecR; pfam02132 1197719001307 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1197719001308 putative active site [active] 1197719001309 putative metal-binding site [ion binding]; other site 1197719001310 tetramer interface [polypeptide binding]; other site 1197719001311 heat shock protein 90; Provisional; Region: PRK05218 1197719001312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719001313 ATP binding site [chemical binding]; other site 1197719001314 Mg2+ binding site [ion binding]; other site 1197719001315 G-X-G motif; other site 1197719001316 adenylate kinase; Reviewed; Region: adk; PRK00279 1197719001317 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1197719001318 AMP-binding site [chemical binding]; other site 1197719001319 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1197719001320 ferrochelatase; Reviewed; Region: hemH; PRK00035 1197719001321 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1197719001322 C-terminal domain interface [polypeptide binding]; other site 1197719001323 active site 1197719001324 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1197719001325 active site 1197719001326 N-terminal domain interface [polypeptide binding]; other site 1197719001327 acetyl esterase; Provisional; Region: PRK10162 1197719001328 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1197719001329 inosine/guanosine kinase; Provisional; Region: PRK15074 1197719001330 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719001331 putative cation:proton antiport protein; Provisional; Region: PRK10669 1197719001332 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1197719001333 TrkA-N domain; Region: TrkA_N; pfam02254 1197719001334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1197719001336 putative substrate translocation pore; other site 1197719001337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001338 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1197719001339 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1197719001340 active site 1197719001341 metal binding site [ion binding]; metal-binding site 1197719001342 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1197719001343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719001344 non-specific DNA binding site [nucleotide binding]; other site 1197719001345 salt bridge; other site 1197719001346 sequence-specific DNA binding site [nucleotide binding]; other site 1197719001347 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 1197719001348 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1197719001349 Integrase core domain; Region: rve; pfam00665 1197719001350 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1197719001351 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 1197719001352 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1197719001353 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1197719001354 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1197719001355 hypothetical protein; Region: PHA00675 1197719001356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719001357 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 1197719001358 Mor transcription activator family; Region: Mor; cl02360 1197719001359 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1197719001360 DNA methylase; Region: N6_N4_Mtase; cl17433 1197719001361 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1197719001362 catalytic residue [active] 1197719001363 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 1197719001364 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1197719001365 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1197719001366 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1197719001367 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 1197719001368 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 1197719001369 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1197719001370 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 1197719001371 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1197719001372 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1197719001373 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1197719001374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1197719001375 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 1197719001376 Domain of unknown function (DUF1834); Region: DUF1834; pfam08873 1197719001377 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1197719001378 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1197719001379 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1197719001380 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 1197719001381 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1197719001382 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1197719001383 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1197719001384 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 1197719001385 Phage protein GP46; Region: GP46; cl01814 1197719001386 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1197719001387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 1197719001388 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1197719001389 Phage Tail Collar Domain; Region: Collar; pfam07484 1197719001390 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 1197719001391 ADP-ribose binding site [chemical binding]; other site 1197719001392 putative active site [active] 1197719001393 dimer interface [polypeptide binding]; other site 1197719001394 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719001395 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1197719001396 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1197719001397 putative deacylase active site [active] 1197719001398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1197719001399 copper exporting ATPase; Provisional; Region: copA; PRK10671 1197719001400 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1197719001401 metal-binding site [ion binding] 1197719001402 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1197719001403 metal-binding site [ion binding] 1197719001404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1197719001405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719001406 motif II; other site 1197719001407 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1197719001408 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1197719001409 DNA binding residues [nucleotide binding] 1197719001410 dimer interface [polypeptide binding]; other site 1197719001411 copper binding site [ion binding]; other site 1197719001412 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1197719001413 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1197719001414 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1197719001415 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1197719001416 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1197719001417 Walker A/P-loop; other site 1197719001418 ATP binding site [chemical binding]; other site 1197719001419 Q-loop/lid; other site 1197719001420 ABC transporter signature motif; other site 1197719001421 Walker B; other site 1197719001422 D-loop; other site 1197719001423 H-loop/switch region; other site 1197719001424 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1197719001425 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1197719001426 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1197719001427 oxidoreductase; Provisional; Region: PRK08017 1197719001428 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1197719001429 NADP binding site [chemical binding]; other site 1197719001430 active site 1197719001431 steroid binding site; other site 1197719001432 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1197719001433 active site 1197719001434 catalytic triad [active] 1197719001435 oxyanion hole [active] 1197719001436 switch loop; other site 1197719001437 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1197719001438 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1197719001439 Walker A/P-loop; other site 1197719001440 ATP binding site [chemical binding]; other site 1197719001441 Q-loop/lid; other site 1197719001442 ABC transporter signature motif; other site 1197719001443 Walker B; other site 1197719001444 D-loop; other site 1197719001445 H-loop/switch region; other site 1197719001446 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1197719001447 FtsX-like permease family; Region: FtsX; pfam02687 1197719001448 FtsX-like permease family; Region: FtsX; pfam02687 1197719001449 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1197719001450 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1197719001451 active site residue [active] 1197719001452 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1197719001453 ATP-grasp domain; Region: ATP-grasp; pfam02222 1197719001454 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1197719001455 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1197719001456 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1197719001457 putative active site [active] 1197719001458 putative metal binding site [ion binding]; other site 1197719001459 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1197719001460 substrate binding site [chemical binding]; other site 1197719001461 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1197719001462 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1197719001463 active site 1197719001464 HIGH motif; other site 1197719001465 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1197719001466 KMSKS motif; other site 1197719001467 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1197719001468 tRNA binding surface [nucleotide binding]; other site 1197719001469 anticodon binding site; other site 1197719001470 ribosome-associated protein; Provisional; Region: PRK11507 1197719001471 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1197719001472 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1197719001473 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1197719001474 homodimer interface [polypeptide binding]; other site 1197719001475 NADP binding site [chemical binding]; other site 1197719001476 substrate binding site [chemical binding]; other site 1197719001477 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 1197719001478 Cupin; Region: Cupin_6; pfam12852 1197719001479 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1197719001480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719001481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719001482 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1197719001483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719001484 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1197719001485 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719001486 Predicted membrane protein [Function unknown]; Region: COG3059 1197719001487 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1197719001488 phenylalanine transporter; Provisional; Region: PRK10249 1197719001489 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1197719001490 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1197719001491 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1197719001492 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1197719001493 active site 1197719001494 oxyanion hole [active] 1197719001495 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1197719001496 catalytic triad [active] 1197719001497 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1197719001498 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1197719001499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719001500 ATP binding site [chemical binding]; other site 1197719001501 Walker B motif; other site 1197719001502 arginine finger; other site 1197719001503 Transcriptional antiterminator [Transcription]; Region: COG3933 1197719001504 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1197719001505 active pocket/dimerization site; other site 1197719001506 active site 1197719001507 phosphorylation site [posttranslational modification] 1197719001508 PRD domain; Region: PRD; pfam00874 1197719001509 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1197719001510 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1197719001511 putative active site [active] 1197719001512 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1197719001513 dimer interface [polypeptide binding]; other site 1197719001514 active site 1197719001515 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1197719001516 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1197719001517 dimer interface [polypeptide binding]; other site 1197719001518 active site 1197719001519 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1197719001520 dimer interface [polypeptide binding]; other site 1197719001521 active site 1197719001522 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1197719001523 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1197719001524 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1197719001525 active site 1197719001526 phosphorylation site [posttranslational modification] 1197719001527 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1197719001528 active site 1197719001529 active pocket/dimerization site; other site 1197719001530 phosphorylation site [posttranslational modification] 1197719001531 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1197719001532 dimer interface [polypeptide binding]; other site 1197719001533 FMN binding site [chemical binding]; other site 1197719001534 hypothetical protein; Provisional; Region: PRK10250 1197719001535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1197719001536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719001537 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1197719001538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719001539 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1197719001540 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1197719001541 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1197719001542 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1197719001543 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1197719001544 outer membrane receptor FepA; Provisional; Region: PRK13524 1197719001545 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1197719001546 N-terminal plug; other site 1197719001547 ligand-binding site [chemical binding]; other site 1197719001548 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1197719001549 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1197719001550 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1197719001551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1197719001552 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1197719001553 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1197719001554 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1197719001555 acyl-activating enzyme (AAE) consensus motif; other site 1197719001556 AMP binding site [chemical binding]; other site 1197719001557 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1197719001558 LPS O-antigen length regulator; Provisional; Region: PRK10381 1197719001559 Chain length determinant protein; Region: Wzz; pfam02706 1197719001560 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1197719001561 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1197719001562 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1197719001563 Walker A/P-loop; other site 1197719001564 ATP binding site [chemical binding]; other site 1197719001565 Q-loop/lid; other site 1197719001566 ABC transporter signature motif; other site 1197719001567 Walker B; other site 1197719001568 D-loop; other site 1197719001569 H-loop/switch region; other site 1197719001570 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1197719001571 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719001572 ABC-ATPase subunit interface; other site 1197719001573 dimer interface [polypeptide binding]; other site 1197719001574 putative PBP binding regions; other site 1197719001575 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1197719001576 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719001577 ABC-ATPase subunit interface; other site 1197719001578 dimer interface [polypeptide binding]; other site 1197719001579 putative PBP binding regions; other site 1197719001580 enterobactin exporter EntS; Provisional; Region: PRK10489 1197719001581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001582 putative substrate translocation pore; other site 1197719001583 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1197719001584 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1197719001585 siderophore binding site; other site 1197719001586 isochorismate synthase EntC; Provisional; Region: PRK15016 1197719001587 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1197719001588 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1197719001589 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1197719001590 acyl-activating enzyme (AAE) consensus motif; other site 1197719001591 active site 1197719001592 AMP binding site [chemical binding]; other site 1197719001593 substrate binding site [chemical binding]; other site 1197719001594 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1197719001595 hydrophobic substrate binding pocket; other site 1197719001596 Isochorismatase family; Region: Isochorismatase; pfam00857 1197719001597 active site 1197719001598 conserved cis-peptide bond; other site 1197719001599 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1197719001600 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1197719001601 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1197719001602 putative NAD(P) binding site [chemical binding]; other site 1197719001603 active site 1197719001604 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1197719001605 CoenzymeA binding site [chemical binding]; other site 1197719001606 subunit interaction site [polypeptide binding]; other site 1197719001607 PHB binding site; other site 1197719001608 carbon starvation protein A; Provisional; Region: PRK15015 1197719001609 Carbon starvation protein CstA; Region: CstA; pfam02554 1197719001610 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1197719001611 Uncharacterized small protein [Function unknown]; Region: COG2879 1197719001612 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1197719001613 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1197719001614 putative active site [active] 1197719001615 metal binding site [ion binding]; metal-binding site 1197719001616 methionine aminotransferase; Validated; Region: PRK09082 1197719001617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719001618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719001619 homodimer interface [polypeptide binding]; other site 1197719001620 catalytic residue [active] 1197719001621 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1197719001622 ParB-like nuclease domain; Region: ParBc; pfam02195 1197719001623 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1197719001624 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1197719001625 Active Sites [active] 1197719001626 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1197719001627 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1197719001628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719001629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719001630 dimerization interface [polypeptide binding]; other site 1197719001631 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1197719001632 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1197719001633 dimerization domain [polypeptide binding]; other site 1197719001634 dimer interface [polypeptide binding]; other site 1197719001635 catalytic residues [active] 1197719001636 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1197719001637 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1197719001638 dimer interface [polypeptide binding]; other site 1197719001639 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1197719001640 catalytic triad [active] 1197719001641 peroxidatic and resolving cysteines [active] 1197719001642 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1197719001643 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1197719001644 catalytic residue [active] 1197719001645 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1197719001646 catalytic residues [active] 1197719001647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719001648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719001649 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1197719001650 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1197719001651 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1197719001652 putative molybdopterin cofactor binding site [chemical binding]; other site 1197719001653 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1197719001654 molybdopterin cofactor binding site; other site 1197719001655 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1197719001656 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1197719001657 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1197719001658 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1197719001659 Ligand Binding Site [chemical binding]; other site 1197719001660 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1197719001661 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1197719001662 NAD binding site [chemical binding]; other site 1197719001663 catalytic Zn binding site [ion binding]; other site 1197719001664 structural Zn binding site [ion binding]; other site 1197719001665 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1197719001666 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1197719001667 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1197719001668 B1 nucleotide binding pocket [chemical binding]; other site 1197719001669 B2 nucleotide binding pocket [chemical binding]; other site 1197719001670 CAS motifs; other site 1197719001671 active site 1197719001672 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719001673 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1197719001674 transmembrane helices; other site 1197719001675 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1197719001676 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1197719001677 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1197719001678 Coenzyme A transferase; Region: CoA_trans; cl17247 1197719001679 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1197719001680 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1197719001681 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1197719001682 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1197719001683 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1197719001684 putative active site [active] 1197719001685 (T/H)XGH motif; other site 1197719001686 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1197719001687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719001688 putative active site [active] 1197719001689 heme pocket [chemical binding]; other site 1197719001690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719001691 ATP binding site [chemical binding]; other site 1197719001692 Mg2+ binding site [ion binding]; other site 1197719001693 G-X-G motif; other site 1197719001694 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1197719001695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719001696 active site 1197719001697 phosphorylation site [posttranslational modification] 1197719001698 intermolecular recognition site; other site 1197719001699 dimerization interface [polypeptide binding]; other site 1197719001700 Transcriptional regulator; Region: CitT; pfam12431 1197719001701 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1197719001702 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1197719001703 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1197719001704 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1197719001705 DNA-binding site [nucleotide binding]; DNA binding site 1197719001706 RNA-binding motif; other site 1197719001707 chromosome condensation membrane protein; Provisional; Region: PRK14196 1197719001708 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1197719001709 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1197719001710 putative active site [active] 1197719001711 catalytic triad [active] 1197719001712 putative dimer interface [polypeptide binding]; other site 1197719001713 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1197719001714 lipoyl synthase; Provisional; Region: PRK05481 1197719001715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719001716 FeS/SAM binding site; other site 1197719001717 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1197719001718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719001719 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1197719001720 substrate binding pocket [chemical binding]; other site 1197719001721 dimerization interface [polypeptide binding]; other site 1197719001722 lipoate-protein ligase B; Provisional; Region: PRK14342 1197719001723 hypothetical protein; Provisional; Region: PRK04998 1197719001724 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1197719001725 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1197719001726 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1197719001727 rare lipoprotein A; Provisional; Region: PRK10672 1197719001728 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1197719001729 Sporulation related domain; Region: SPOR; pfam05036 1197719001730 cell wall shape-determining protein; Provisional; Region: PRK10794 1197719001731 penicillin-binding protein 2; Provisional; Region: PRK10795 1197719001732 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1197719001733 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1197719001734 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1197719001735 ribosome-associated protein; Provisional; Region: PRK11538 1197719001736 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1197719001737 catalytic core [active] 1197719001738 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1197719001739 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1197719001740 active site 1197719001741 (T/H)XGH motif; other site 1197719001742 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1197719001743 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1197719001744 Lipopolysaccharide-assembly; Region: LptE; cl01125 1197719001745 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1197719001746 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1197719001747 HIGH motif; other site 1197719001748 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1197719001749 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1197719001750 active site 1197719001751 KMSKS motif; other site 1197719001752 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1197719001753 tRNA binding surface [nucleotide binding]; other site 1197719001754 hypothetical protein; Provisional; Region: PRK11032 1197719001755 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1197719001756 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1197719001757 active site 1197719001758 tetramer interface [polypeptide binding]; other site 1197719001759 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1197719001760 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1197719001761 Walker A/P-loop; other site 1197719001762 ATP binding site [chemical binding]; other site 1197719001763 Q-loop/lid; other site 1197719001764 ABC transporter signature motif; other site 1197719001765 Walker B; other site 1197719001766 D-loop; other site 1197719001767 H-loop/switch region; other site 1197719001768 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719001769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719001770 dimer interface [polypeptide binding]; other site 1197719001771 conserved gate region; other site 1197719001772 putative PBP binding loops; other site 1197719001773 ABC-ATPase subunit interface; other site 1197719001774 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719001775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719001776 dimer interface [polypeptide binding]; other site 1197719001777 conserved gate region; other site 1197719001778 putative PBP binding loops; other site 1197719001779 ABC-ATPase subunit interface; other site 1197719001780 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1197719001781 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719001782 substrate binding pocket [chemical binding]; other site 1197719001783 membrane-bound complex binding site; other site 1197719001784 hinge residues; other site 1197719001785 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1197719001786 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1197719001787 putative active site [active] 1197719001788 catalytic triad [active] 1197719001789 putative dimer interface [polypeptide binding]; other site 1197719001790 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1197719001791 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1197719001792 Transporter associated domain; Region: CorC_HlyC; smart01091 1197719001793 metal-binding heat shock protein; Provisional; Region: PRK00016 1197719001794 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1197719001795 PhoH-like protein; Region: PhoH; pfam02562 1197719001796 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1197719001797 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1197719001798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719001799 FeS/SAM binding site; other site 1197719001800 TRAM domain; Region: TRAM; pfam01938 1197719001801 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1197719001802 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1197719001803 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1197719001804 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1197719001805 active site 1197719001806 dimer interface [polypeptide binding]; other site 1197719001807 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1197719001808 Ligand Binding Site [chemical binding]; other site 1197719001809 Molecular Tunnel; other site 1197719001810 UMP phosphatase; Provisional; Region: PRK10444 1197719001811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719001812 active site 1197719001813 motif I; other site 1197719001814 motif II; other site 1197719001815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719001816 MarR family; Region: MarR; pfam01047 1197719001817 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1197719001818 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1197719001819 nucleotide binding site [chemical binding]; other site 1197719001820 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1197719001821 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1197719001822 active site 1197719001823 dimer interface [polypeptide binding]; other site 1197719001824 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1197719001825 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1197719001826 active site 1197719001827 trimer interface [polypeptide binding]; other site 1197719001828 allosteric site; other site 1197719001829 active site lid [active] 1197719001830 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1197719001831 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1197719001832 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1197719001833 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1197719001834 active site turn [active] 1197719001835 phosphorylation site [posttranslational modification] 1197719001836 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1197719001837 HPr interaction site; other site 1197719001838 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1197719001839 active site 1197719001840 phosphorylation site [posttranslational modification] 1197719001841 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1197719001842 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1197719001843 active site 1197719001844 HIGH motif; other site 1197719001845 nucleotide binding site [chemical binding]; other site 1197719001846 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1197719001847 KMSKS motif; other site 1197719001848 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1197719001849 outer membrane porin, OprD family; Region: OprD; pfam03573 1197719001850 YbfN-like lipoprotein; Region: YbfN; pfam13982 1197719001851 citrate-proton symporter; Provisional; Region: PRK15075 1197719001852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001853 putative substrate translocation pore; other site 1197719001854 tricarballylate utilization protein B; Provisional; Region: PRK15033 1197719001855 tricarballylate dehydrogenase; Validated; Region: PRK08274 1197719001856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719001857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719001858 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1197719001859 putative dimerization interface [polypeptide binding]; other site 1197719001860 ferric uptake regulator; Provisional; Region: fur; PRK09462 1197719001861 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1197719001862 metal binding site 2 [ion binding]; metal-binding site 1197719001863 putative DNA binding helix; other site 1197719001864 metal binding site 1 [ion binding]; metal-binding site 1197719001865 dimer interface [polypeptide binding]; other site 1197719001866 structural Zn2+ binding site [ion binding]; other site 1197719001867 flavodoxin FldA; Validated; Region: PRK09267 1197719001868 LexA regulated protein; Provisional; Region: PRK11675 1197719001869 acyl-CoA esterase; Provisional; Region: PRK10673 1197719001870 PGAP1-like protein; Region: PGAP1; pfam07819 1197719001871 replication initiation regulator SeqA; Provisional; Region: PRK11187 1197719001872 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1197719001873 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1197719001874 active site 1197719001875 substrate binding site [chemical binding]; other site 1197719001876 metal binding site [ion binding]; metal-binding site 1197719001877 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1197719001878 putrescine transporter; Provisional; Region: potE; PRK10655 1197719001879 ornithine decarboxylase; Provisional; Region: PRK13578 1197719001880 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1197719001881 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1197719001882 homodimer interface [polypeptide binding]; other site 1197719001883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719001884 catalytic residue [active] 1197719001885 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1197719001886 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1197719001887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719001888 active site 1197719001889 phosphorylation site [posttranslational modification] 1197719001890 intermolecular recognition site; other site 1197719001891 dimerization interface [polypeptide binding]; other site 1197719001892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719001893 DNA binding site [nucleotide binding] 1197719001894 sensor protein KdpD; Provisional; Region: PRK10490 1197719001895 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1197719001896 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1197719001897 Ligand Binding Site [chemical binding]; other site 1197719001898 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1197719001899 GAF domain; Region: GAF_3; pfam13492 1197719001900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719001901 dimer interface [polypeptide binding]; other site 1197719001902 phosphorylation site [posttranslational modification] 1197719001903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719001904 ATP binding site [chemical binding]; other site 1197719001905 Mg2+ binding site [ion binding]; other site 1197719001906 G-X-G motif; other site 1197719001907 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1197719001908 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1197719001909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1197719001910 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1197719001911 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1197719001912 Protein of unknown function (DUF796); Region: DUF796; cl01226 1197719001913 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1197719001914 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1197719001915 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1197719001916 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1197719001917 DNA photolyase; Region: DNA_photolyase; pfam00875 1197719001918 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1197719001919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719001920 putative substrate translocation pore; other site 1197719001921 POT family; Region: PTR2; pfam00854 1197719001922 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1197719001923 metal-binding protein; Provisional; Region: PRK10799 1197719001924 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1197719001925 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1197719001926 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1197719001927 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1197719001928 putative active site [active] 1197719001929 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719001930 active site 1197719001931 DNA binding site [nucleotide binding] 1197719001932 Int/Topo IB signature motif; other site 1197719001933 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1197719001934 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1197719001935 Substrate binding site; other site 1197719001936 Cupin domain; Region: Cupin_2; cl17218 1197719001937 phosphomannomutase CpsG; Provisional; Region: PRK15414 1197719001938 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1197719001939 active site 1197719001940 substrate binding site [chemical binding]; other site 1197719001941 metal binding site [ion binding]; metal-binding site 1197719001942 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1197719001943 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1197719001944 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1197719001945 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1197719001946 Walker A/P-loop; other site 1197719001947 ATP binding site [chemical binding]; other site 1197719001948 Q-loop/lid; other site 1197719001949 ABC transporter signature motif; other site 1197719001950 Walker B; other site 1197719001951 D-loop; other site 1197719001952 H-loop/switch region; other site 1197719001953 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1197719001954 putative carbohydrate binding site [chemical binding]; other site 1197719001955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719001956 S-adenosylmethionine binding site [chemical binding]; other site 1197719001957 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1197719001958 active site 1197719001959 ATP binding site [chemical binding]; other site 1197719001960 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1197719001961 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1197719001962 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1197719001963 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1197719001964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1197719001965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1197719001966 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1197719001967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1197719001968 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1197719001969 putative ADP-binding pocket [chemical binding]; other site 1197719001970 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1197719001971 active site 1197719001972 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1197719001973 Predicted membrane protein [Function unknown]; Region: COG3817 1197719001974 endonuclease VIII; Provisional; Region: PRK10445 1197719001975 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1197719001976 DNA binding site [nucleotide binding] 1197719001977 catalytic residue [active] 1197719001978 putative catalytic residues [active] 1197719001979 H2TH interface [polypeptide binding]; other site 1197719001980 intercalation triad [nucleotide binding]; other site 1197719001981 substrate specificity determining residue; other site 1197719001982 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1197719001983 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1197719001984 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1197719001985 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1197719001986 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1197719001987 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1197719001988 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1197719001989 dimer interface [polypeptide binding]; other site 1197719001990 active site 1197719001991 citrylCoA binding site [chemical binding]; other site 1197719001992 NADH binding [chemical binding]; other site 1197719001993 cationic pore residues; other site 1197719001994 oxalacetate/citrate binding site [chemical binding]; other site 1197719001995 coenzyme A binding site [chemical binding]; other site 1197719001996 catalytic triad [active] 1197719001997 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1197719001998 Iron-sulfur protein interface; other site 1197719001999 proximal quinone binding site [chemical binding]; other site 1197719002000 SdhD (CybS) interface [polypeptide binding]; other site 1197719002001 proximal heme binding site [chemical binding]; other site 1197719002002 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1197719002003 SdhC subunit interface [polypeptide binding]; other site 1197719002004 proximal heme binding site [chemical binding]; other site 1197719002005 cardiolipin binding site; other site 1197719002006 Iron-sulfur protein interface; other site 1197719002007 proximal quinone binding site [chemical binding]; other site 1197719002008 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1197719002009 L-aspartate oxidase; Provisional; Region: PRK06175 1197719002010 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1197719002011 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1197719002012 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1197719002013 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1197719002014 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1197719002015 TPP-binding site [chemical binding]; other site 1197719002016 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1197719002017 dimer interface [polypeptide binding]; other site 1197719002018 PYR/PP interface [polypeptide binding]; other site 1197719002019 TPP binding site [chemical binding]; other site 1197719002020 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1197719002021 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1197719002022 E3 interaction surface; other site 1197719002023 lipoyl attachment site [posttranslational modification]; other site 1197719002024 e3 binding domain; Region: E3_binding; pfam02817 1197719002025 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1197719002026 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1197719002027 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1197719002028 CoA-ligase; Region: Ligase_CoA; pfam00549 1197719002029 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1197719002030 CoA binding domain; Region: CoA_binding; smart00881 1197719002031 CoA-ligase; Region: Ligase_CoA; pfam00549 1197719002032 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1197719002033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719002034 DNA-binding site [nucleotide binding]; DNA binding site 1197719002035 UTRA domain; Region: UTRA; pfam07702 1197719002036 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1197719002037 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719002038 active site 1197719002039 phosphorylation site [posttranslational modification] 1197719002040 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1197719002041 active site 1197719002042 P-loop; other site 1197719002043 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1197719002044 alpha-mannosidase; Provisional; Region: PRK09819 1197719002045 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1197719002046 active site 1197719002047 metal binding site [ion binding]; metal-binding site 1197719002048 catalytic site [active] 1197719002049 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1197719002050 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1197719002051 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1197719002052 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1197719002053 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1197719002054 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 1197719002055 hypothetical protein; Provisional; Region: PRK10588 1197719002056 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1197719002057 active site 1197719002058 colicin uptake protein TolQ; Provisional; Region: PRK10801 1197719002059 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1197719002060 colicin uptake protein TolR; Provisional; Region: PRK11024 1197719002061 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1197719002062 TolA C-terminal; Region: TolA; pfam06519 1197719002063 translocation protein TolB; Provisional; Region: tolB; PRK03629 1197719002064 TolB amino-terminal domain; Region: TolB_N; pfam04052 1197719002065 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1197719002066 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1197719002067 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1197719002068 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1197719002069 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1197719002070 ligand binding site [chemical binding]; other site 1197719002071 tol-pal system protein YbgF; Provisional; Region: PRK10803 1197719002072 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1197719002073 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1197719002074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1197719002075 quinolinate synthetase; Provisional; Region: PRK09375 1197719002076 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1197719002077 zinc transporter ZitB; Provisional; Region: PRK03557 1197719002078 YbgS-like protein; Region: YbgS; pfam13985 1197719002079 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1197719002080 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1197719002081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1197719002082 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1197719002083 catalytic core [active] 1197719002084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1197719002085 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1197719002086 active site 1197719002087 catalytic residues [active] 1197719002088 galactokinase; Provisional; Region: PRK05101 1197719002089 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1197719002090 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1197719002091 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1197719002092 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1197719002093 dimer interface [polypeptide binding]; other site 1197719002094 active site 1197719002095 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1197719002096 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1197719002097 NAD binding site [chemical binding]; other site 1197719002098 homodimer interface [polypeptide binding]; other site 1197719002099 active site 1197719002100 substrate binding site [chemical binding]; other site 1197719002101 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1197719002102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002103 Walker A/P-loop; other site 1197719002104 ATP binding site [chemical binding]; other site 1197719002105 Q-loop/lid; other site 1197719002106 ABC transporter signature motif; other site 1197719002107 Walker B; other site 1197719002108 D-loop; other site 1197719002109 H-loop/switch region; other site 1197719002110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002111 Walker A/P-loop; other site 1197719002112 ATP binding site [chemical binding]; other site 1197719002113 Q-loop/lid; other site 1197719002114 ABC transporter signature motif; other site 1197719002115 Walker B; other site 1197719002116 D-loop; other site 1197719002117 H-loop/switch region; other site 1197719002118 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1197719002119 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1197719002120 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1197719002121 TOBE domain; Region: TOBE; pfam03459 1197719002122 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1197719002123 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1197719002124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719002125 substrate binding pocket [chemical binding]; other site 1197719002126 membrane-bound complex binding site; other site 1197719002127 hinge residues; other site 1197719002128 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1197719002129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002130 dimer interface [polypeptide binding]; other site 1197719002131 conserved gate region; other site 1197719002132 putative PBP binding loops; other site 1197719002133 ABC-ATPase subunit interface; other site 1197719002134 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1197719002135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002136 Walker A/P-loop; other site 1197719002137 ATP binding site [chemical binding]; other site 1197719002138 Q-loop/lid; other site 1197719002139 ABC transporter signature motif; other site 1197719002140 Walker B; other site 1197719002141 D-loop; other site 1197719002142 H-loop/switch region; other site 1197719002143 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1197719002144 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1197719002145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719002146 active site 1197719002147 motif I; other site 1197719002148 motif II; other site 1197719002149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719002150 6-phosphogluconolactonase; Provisional; Region: PRK11028 1197719002151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719002152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719002153 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1197719002154 putative dimerization interface [polypeptide binding]; other site 1197719002155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1197719002156 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719002157 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1197719002158 transmembrane helices; other site 1197719002159 putative hydratase; Provisional; Region: PRK11413 1197719002160 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1197719002161 substrate binding site [chemical binding]; other site 1197719002162 ligand binding site [chemical binding]; other site 1197719002163 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1197719002164 substrate binding site [chemical binding]; other site 1197719002165 acyl-CoA thioesterase; Provisional; Region: PRK10531 1197719002166 putative pectinesterase; Region: PLN02432; cl01911 1197719002167 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1197719002168 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1197719002169 dimer interface [polypeptide binding]; other site 1197719002170 active site 1197719002171 Int/Topo IB signature motif; other site 1197719002172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1197719002173 Integrase core domain; Region: rve_3; pfam13683 1197719002174 BRO family, N-terminal domain; Region: Bro-N; smart01040 1197719002175 imidazolonepropionase; Validated; Region: PRK09356 1197719002176 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1197719002177 active site 1197719002178 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1197719002179 putative active site [active] 1197719002180 putative metal binding site [ion binding]; other site 1197719002181 histidine utilization repressor; Provisional; Region: PRK14999 1197719002182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719002183 DNA-binding site [nucleotide binding]; DNA binding site 1197719002184 UTRA domain; Region: UTRA; pfam07702 1197719002185 urocanate hydratase; Provisional; Region: PRK05414 1197719002186 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1197719002187 active sites [active] 1197719002188 tetramer interface [polypeptide binding]; other site 1197719002189 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1197719002190 substrate binding site [chemical binding]; other site 1197719002191 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1197719002192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1197719002193 inhibitor-cofactor binding pocket; inhibition site 1197719002194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719002195 catalytic residue [active] 1197719002196 biotin synthase; Provisional; Region: PRK15108 1197719002197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719002198 FeS/SAM binding site; other site 1197719002199 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1197719002200 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1197719002201 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1197719002202 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1197719002203 catalytic residue [active] 1197719002204 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1197719002205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719002206 S-adenosylmethionine binding site [chemical binding]; other site 1197719002207 AAA domain; Region: AAA_26; pfam13500 1197719002208 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1197719002209 excinuclease ABC subunit B; Provisional; Region: PRK05298 1197719002210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719002211 ATP binding site [chemical binding]; other site 1197719002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719002213 nucleotide binding region [chemical binding]; other site 1197719002214 ATP-binding site [chemical binding]; other site 1197719002215 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1197719002216 UvrB/uvrC motif; Region: UVR; pfam02151 1197719002217 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1197719002218 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1197719002219 Leucine-rich repeats, bacterial type; Region: LRR_BAC; smart00364 1197719002220 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1197719002221 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1197719002222 putative substrate binding pocket [chemical binding]; other site 1197719002223 dimer interface [polypeptide binding]; other site 1197719002224 phosphate binding site [ion binding]; other site 1197719002225 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1197719002226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719002227 FeS/SAM binding site; other site 1197719002228 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1197719002229 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1197719002230 MPT binding site; other site 1197719002231 trimer interface [polypeptide binding]; other site 1197719002232 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1197719002233 trimer interface [polypeptide binding]; other site 1197719002234 dimer interface [polypeptide binding]; other site 1197719002235 putative active site [active] 1197719002236 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1197719002237 MoaE interaction surface [polypeptide binding]; other site 1197719002238 MoeB interaction surface [polypeptide binding]; other site 1197719002239 thiocarboxylated glycine; other site 1197719002240 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1197719002241 MoaE homodimer interface [polypeptide binding]; other site 1197719002242 MoaD interaction [polypeptide binding]; other site 1197719002243 active site residues [active] 1197719002244 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1197719002245 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1197719002246 Predicted integral membrane protein [Function unknown]; Region: COG0392 1197719002247 cardiolipin synthase 2; Provisional; Region: PRK11263 1197719002248 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1197719002249 putative active site [active] 1197719002250 catalytic site [active] 1197719002251 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1197719002252 putative active site [active] 1197719002253 catalytic site [active] 1197719002254 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1197719002255 putative catalytic site [active] 1197719002256 putative metal binding site [ion binding]; other site 1197719002257 putative phosphate binding site [ion binding]; other site 1197719002258 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1197719002259 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1197719002260 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1197719002261 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1197719002262 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1197719002263 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1197719002264 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1197719002265 Walker A/P-loop; other site 1197719002266 ATP binding site [chemical binding]; other site 1197719002267 Q-loop/lid; other site 1197719002268 ABC transporter signature motif; other site 1197719002269 Walker B; other site 1197719002270 D-loop; other site 1197719002271 H-loop/switch region; other site 1197719002272 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1197719002273 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1197719002274 Walker A/P-loop; other site 1197719002275 ATP binding site [chemical binding]; other site 1197719002276 Q-loop/lid; other site 1197719002277 ABC transporter signature motif; other site 1197719002278 Walker B; other site 1197719002279 D-loop; other site 1197719002280 H-loop/switch region; other site 1197719002281 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1197719002282 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719002283 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719002284 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1197719002285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719002286 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1197719002287 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1197719002288 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1197719002289 ATP binding site [chemical binding]; other site 1197719002290 Mg++ binding site [ion binding]; other site 1197719002291 motif III; other site 1197719002292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719002293 nucleotide binding region [chemical binding]; other site 1197719002294 ATP-binding site [chemical binding]; other site 1197719002295 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1197719002296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1197719002297 DEAD_2; Region: DEAD_2; pfam06733 1197719002298 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1197719002299 glycosyl transferase family protein; Provisional; Region: PRK08136 1197719002300 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1197719002301 hypothetical protein; Provisional; Region: PRK10259 1197719002302 hypothetical protein; Provisional; Region: PRK11019 1197719002303 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1197719002304 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1197719002305 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1197719002306 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1197719002307 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1197719002308 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1197719002309 Walker A/P-loop; other site 1197719002310 ATP binding site [chemical binding]; other site 1197719002311 Q-loop/lid; other site 1197719002312 ABC transporter signature motif; other site 1197719002313 Walker B; other site 1197719002314 D-loop; other site 1197719002315 H-loop/switch region; other site 1197719002316 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719002317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002318 dimer interface [polypeptide binding]; other site 1197719002319 conserved gate region; other site 1197719002320 putative PBP binding loops; other site 1197719002321 ABC-ATPase subunit interface; other site 1197719002322 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1197719002323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719002324 substrate binding pocket [chemical binding]; other site 1197719002325 membrane-bound complex binding site; other site 1197719002326 hinge residues; other site 1197719002327 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1197719002328 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1197719002329 dimerization interface [polypeptide binding]; other site 1197719002330 DPS ferroxidase diiron center [ion binding]; other site 1197719002331 ion pore; other site 1197719002332 threonine and homoserine efflux system; Provisional; Region: PRK10532 1197719002333 EamA-like transporter family; Region: EamA; pfam00892 1197719002334 outer membrane protein X; Provisional; Region: ompX; PRK09408 1197719002335 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1197719002336 Sulfatase; Region: Sulfatase; pfam00884 1197719002337 manganese transport regulator MntR; Provisional; Region: PRK11050 1197719002338 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1197719002339 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1197719002340 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719002341 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1197719002342 transmembrane helices; other site 1197719002343 L,D-transpeptidase; Provisional; Region: PRK10260 1197719002344 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1197719002345 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1197719002346 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719002347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002348 Walker A/P-loop; other site 1197719002349 ATP binding site [chemical binding]; other site 1197719002350 ABC transporter signature motif; other site 1197719002351 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719002352 Walker B; other site 1197719002353 ABC transporter; Region: ABC_tran_2; pfam12848 1197719002354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719002355 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1197719002356 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1197719002357 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1197719002358 putative active site [active] 1197719002359 putative catalytic site [active] 1197719002360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719002361 D-galactonate transporter; Region: 2A0114; TIGR00893 1197719002362 putative substrate translocation pore; other site 1197719002363 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1197719002364 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719002365 DNA binding site [nucleotide binding] 1197719002366 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1197719002367 ligand binding site [chemical binding]; other site 1197719002368 dimerization interface [polypeptide binding]; other site 1197719002369 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1197719002370 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1197719002371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719002372 active site 1197719002373 motif I; other site 1197719002374 motif II; other site 1197719002375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719002376 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1197719002377 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1197719002378 dimer interface [polypeptide binding]; other site 1197719002379 active site 1197719002380 glycine loop; other site 1197719002381 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1197719002382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719002383 FeS/SAM binding site; other site 1197719002384 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1197719002385 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1197719002386 ATP binding site [chemical binding]; other site 1197719002387 substrate interface [chemical binding]; other site 1197719002388 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1197719002389 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1197719002390 dimer interface [polypeptide binding]; other site 1197719002391 putative functional site; other site 1197719002392 putative MPT binding site; other site 1197719002393 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1197719002394 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719002395 Walker A/P-loop; other site 1197719002396 ATP binding site [chemical binding]; other site 1197719002397 Q-loop/lid; other site 1197719002398 ABC transporter signature motif; other site 1197719002399 Walker B; other site 1197719002400 D-loop; other site 1197719002401 H-loop/switch region; other site 1197719002402 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1197719002403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719002404 Walker A/P-loop; other site 1197719002405 ATP binding site [chemical binding]; other site 1197719002406 Q-loop/lid; other site 1197719002407 ABC transporter signature motif; other site 1197719002408 Walker B; other site 1197719002409 D-loop; other site 1197719002410 H-loop/switch region; other site 1197719002411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1197719002412 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1197719002413 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1197719002414 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1197719002415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002416 dimer interface [polypeptide binding]; other site 1197719002417 conserved gate region; other site 1197719002418 putative PBP binding loops; other site 1197719002419 ABC-ATPase subunit interface; other site 1197719002420 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1197719002421 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1197719002422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002423 dimer interface [polypeptide binding]; other site 1197719002424 conserved gate region; other site 1197719002425 putative PBP binding loops; other site 1197719002426 ABC-ATPase subunit interface; other site 1197719002427 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1197719002428 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1197719002429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719002430 FeS/SAM binding site; other site 1197719002431 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1197719002432 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1197719002433 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1197719002434 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1197719002435 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1197719002436 putative C-terminal domain interface [polypeptide binding]; other site 1197719002437 putative GSH binding site (G-site) [chemical binding]; other site 1197719002438 putative dimer interface [polypeptide binding]; other site 1197719002439 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1197719002440 putative N-terminal domain interface [polypeptide binding]; other site 1197719002441 putative dimer interface [polypeptide binding]; other site 1197719002442 putative substrate binding pocket (H-site) [chemical binding]; other site 1197719002443 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1197719002444 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1197719002445 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1197719002446 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1197719002447 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1197719002448 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719002449 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1197719002450 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1197719002451 active site 1197719002452 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1197719002453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719002454 putative substrate translocation pore; other site 1197719002455 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1197719002456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719002457 active site 1197719002458 motif I; other site 1197719002459 motif II; other site 1197719002460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719002461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719002462 putative substrate translocation pore; other site 1197719002463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1197719002464 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1197719002465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719002466 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1197719002467 putative transporter; Provisional; Region: PRK04972 1197719002468 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1197719002469 TrkA-C domain; Region: TrkA_C; pfam02080 1197719002470 TrkA-C domain; Region: TrkA_C; pfam02080 1197719002471 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1197719002472 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1197719002473 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1197719002474 GSH binding site [chemical binding]; other site 1197719002475 catalytic residues [active] 1197719002476 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1197719002477 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1197719002478 dimer interface [polypeptide binding]; other site 1197719002479 FMN binding site [chemical binding]; other site 1197719002480 NADPH bind site [chemical binding]; other site 1197719002481 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1197719002482 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1197719002483 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1197719002484 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1197719002485 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1197719002486 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1197719002487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002488 Walker A/P-loop; other site 1197719002489 ATP binding site [chemical binding]; other site 1197719002490 Q-loop/lid; other site 1197719002491 ABC transporter signature motif; other site 1197719002492 Walker B; other site 1197719002493 D-loop; other site 1197719002494 H-loop/switch region; other site 1197719002495 TOBE domain; Region: TOBE_2; pfam08402 1197719002496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002497 dimer interface [polypeptide binding]; other site 1197719002498 conserved gate region; other site 1197719002499 putative PBP binding loops; other site 1197719002500 ABC-ATPase subunit interface; other site 1197719002501 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1197719002502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002503 dimer interface [polypeptide binding]; other site 1197719002504 conserved gate region; other site 1197719002505 putative PBP binding loops; other site 1197719002506 ABC-ATPase subunit interface; other site 1197719002507 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1197719002508 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1197719002509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719002510 S-adenosylmethionine binding site [chemical binding]; other site 1197719002511 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1197719002512 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1197719002513 active site 1197719002514 P-loop; other site 1197719002515 phosphorylation site [posttranslational modification] 1197719002516 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1197719002517 Sulfatase; Region: Sulfatase; cl17466 1197719002518 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1197719002519 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1197719002520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719002521 substrate binding pocket [chemical binding]; other site 1197719002522 membrane-bound complex binding site; other site 1197719002523 hinge residues; other site 1197719002524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002525 dimer interface [polypeptide binding]; other site 1197719002526 conserved gate region; other site 1197719002527 putative PBP binding loops; other site 1197719002528 ABC-ATPase subunit interface; other site 1197719002529 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719002531 dimer interface [polypeptide binding]; other site 1197719002532 conserved gate region; other site 1197719002533 putative PBP binding loops; other site 1197719002534 ABC-ATPase subunit interface; other site 1197719002535 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1197719002536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719002537 substrate binding pocket [chemical binding]; other site 1197719002538 membrane-bound complex binding site; other site 1197719002539 hinge residues; other site 1197719002540 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1197719002541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002542 Walker A/P-loop; other site 1197719002543 ATP binding site [chemical binding]; other site 1197719002544 Q-loop/lid; other site 1197719002545 ABC transporter signature motif; other site 1197719002546 Walker B; other site 1197719002547 D-loop; other site 1197719002548 H-loop/switch region; other site 1197719002549 putative lipoprotein; Provisional; Region: PRK10533 1197719002550 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719002551 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719002552 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719002553 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719002554 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719002555 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719002556 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719002557 hypothetical protein; Provisional; Region: PRK02877 1197719002558 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1197719002559 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1197719002560 amidase catalytic site [active] 1197719002561 Zn binding residues [ion binding]; other site 1197719002562 substrate binding site [chemical binding]; other site 1197719002563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1197719002564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1197719002565 NAD(P) binding site [chemical binding]; other site 1197719002566 active site 1197719002567 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1197719002568 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1197719002569 putative NAD(P) binding site [chemical binding]; other site 1197719002570 putative active site [active] 1197719002571 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1197719002572 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1197719002573 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1197719002574 tetramer interface [polypeptide binding]; other site 1197719002575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719002576 catalytic residue [active] 1197719002577 pyruvate dehydrogenase; Provisional; Region: PRK09124 1197719002578 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1197719002579 PYR/PP interface [polypeptide binding]; other site 1197719002580 dimer interface [polypeptide binding]; other site 1197719002581 tetramer interface [polypeptide binding]; other site 1197719002582 TPP binding site [chemical binding]; other site 1197719002583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1197719002584 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1197719002585 TPP-binding site [chemical binding]; other site 1197719002586 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1197719002587 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1197719002588 FAD binding pocket [chemical binding]; other site 1197719002589 FAD binding motif [chemical binding]; other site 1197719002590 phosphate binding motif [ion binding]; other site 1197719002591 beta-alpha-beta structure motif; other site 1197719002592 NAD binding pocket [chemical binding]; other site 1197719002593 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1197719002594 catalytic loop [active] 1197719002595 iron binding site [ion binding]; other site 1197719002596 hybrid cluster protein; Provisional; Region: PRK05290 1197719002597 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1197719002598 ACS interaction site; other site 1197719002599 CODH interaction site; other site 1197719002600 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1197719002601 hybrid metal cluster; other site 1197719002602 Predicted membrane protein [Function unknown]; Region: COG2431 1197719002603 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1197719002604 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1197719002605 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1197719002606 putative active site [active] 1197719002607 putative metal-binding site [ion binding]; other site 1197719002608 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1197719002609 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1197719002610 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719002611 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719002612 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1197719002613 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1197719002614 Walker A/P-loop; other site 1197719002615 ATP binding site [chemical binding]; other site 1197719002616 Q-loop/lid; other site 1197719002617 ABC transporter signature motif; other site 1197719002618 Walker B; other site 1197719002619 D-loop; other site 1197719002620 H-loop/switch region; other site 1197719002621 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1197719002622 FtsX-like permease family; Region: FtsX; pfam02687 1197719002623 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1197719002624 DNA-binding site [nucleotide binding]; DNA binding site 1197719002625 RNA-binding motif; other site 1197719002626 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1197719002627 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1197719002628 Clp amino terminal domain; Region: Clp_N; pfam02861 1197719002629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719002630 Walker A motif; other site 1197719002631 ATP binding site [chemical binding]; other site 1197719002632 Walker B motif; other site 1197719002633 arginine finger; other site 1197719002634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719002635 Walker A motif; other site 1197719002636 ATP binding site [chemical binding]; other site 1197719002637 Walker B motif; other site 1197719002638 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1197719002639 Isochorismatase family; Region: Isochorismatase; pfam00857 1197719002640 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1197719002641 catalytic triad [active] 1197719002642 dimer interface [polypeptide binding]; other site 1197719002643 conserved cis-peptide bond; other site 1197719002644 Pirin-related protein [General function prediction only]; Region: COG1741 1197719002645 Pirin; Region: Pirin; pfam02678 1197719002646 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1197719002647 LysR family transcriptional regulator; Provisional; Region: PRK14997 1197719002648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719002649 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1197719002650 putative effector binding pocket; other site 1197719002651 putative dimerization interface [polypeptide binding]; other site 1197719002652 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1197719002653 rRNA binding site [nucleotide binding]; other site 1197719002654 predicted 30S ribosome binding site; other site 1197719002655 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1197719002656 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1197719002657 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1197719002658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002659 Walker A/P-loop; other site 1197719002660 ATP binding site [chemical binding]; other site 1197719002661 Q-loop/lid; other site 1197719002662 ABC transporter signature motif; other site 1197719002663 Walker B; other site 1197719002664 D-loop; other site 1197719002665 H-loop/switch region; other site 1197719002666 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1197719002667 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1197719002668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002669 Walker A/P-loop; other site 1197719002670 ATP binding site [chemical binding]; other site 1197719002671 Q-loop/lid; other site 1197719002672 ABC transporter signature motif; other site 1197719002673 Walker B; other site 1197719002674 D-loop; other site 1197719002675 H-loop/switch region; other site 1197719002676 thioredoxin reductase; Provisional; Region: PRK10262 1197719002677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719002678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719002679 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1197719002680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1197719002681 putative DNA binding site [nucleotide binding]; other site 1197719002682 putative Zn2+ binding site [ion binding]; other site 1197719002683 AsnC family; Region: AsnC_trans_reg; pfam01037 1197719002684 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1197719002685 DNA translocase FtsK; Provisional; Region: PRK10263 1197719002686 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1197719002687 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1197719002688 periplasmic chaperone LolA; Region: lolA; TIGR00547 1197719002689 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1197719002690 recombination factor protein RarA; Reviewed; Region: PRK13342 1197719002691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719002692 Walker A motif; other site 1197719002693 ATP binding site [chemical binding]; other site 1197719002694 Walker B motif; other site 1197719002695 arginine finger; other site 1197719002696 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1197719002697 seryl-tRNA synthetase; Provisional; Region: PRK05431 1197719002698 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1197719002699 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1197719002700 dimer interface [polypeptide binding]; other site 1197719002701 active site 1197719002702 motif 1; other site 1197719002703 motif 2; other site 1197719002704 motif 3; other site 1197719002705 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1197719002706 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1197719002707 putative [Fe4-S4] binding site [ion binding]; other site 1197719002708 putative molybdopterin cofactor binding site [chemical binding]; other site 1197719002709 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1197719002710 putative molybdopterin cofactor binding site; other site 1197719002711 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1197719002712 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719002713 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1197719002714 putative MFS family transporter protein; Provisional; Region: PRK03633 1197719002715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719002716 putative substrate translocation pore; other site 1197719002717 inner membrane transporter YjeM; Provisional; Region: PRK15238 1197719002718 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1197719002719 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1197719002720 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1197719002721 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1197719002722 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1197719002723 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719002724 FeS/SAM binding site; other site 1197719002725 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1197719002726 Pyruvate formate lyase 1; Region: PFL1; cd01678 1197719002727 coenzyme A binding site [chemical binding]; other site 1197719002728 active site 1197719002729 catalytic residues [active] 1197719002730 glycine loop; other site 1197719002731 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1197719002732 uncharacterized domain; Region: TIGR00702 1197719002733 YcaO-like family; Region: YcaO; pfam02624 1197719002734 Predicted membrane protein [Function unknown]; Region: COG2323 1197719002735 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1197719002736 homodimer interface [polypeptide binding]; other site 1197719002737 substrate-cofactor binding pocket; other site 1197719002738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719002739 catalytic residue [active] 1197719002740 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1197719002741 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1197719002742 hinge; other site 1197719002743 active site 1197719002744 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1197719002745 cytidylate kinase; Provisional; Region: cmk; PRK00023 1197719002746 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1197719002747 CMP-binding site; other site 1197719002748 The sites determining sugar specificity; other site 1197719002749 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1197719002750 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1197719002751 RNA binding site [nucleotide binding]; other site 1197719002752 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1197719002753 RNA binding site [nucleotide binding]; other site 1197719002754 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1197719002755 RNA binding site [nucleotide binding]; other site 1197719002756 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1197719002757 RNA binding site [nucleotide binding]; other site 1197719002758 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1197719002759 RNA binding site [nucleotide binding]; other site 1197719002760 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1197719002761 RNA binding site [nucleotide binding]; other site 1197719002762 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1197719002763 IHF dimer interface [polypeptide binding]; other site 1197719002764 IHF - DNA interface [nucleotide binding]; other site 1197719002765 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1197719002766 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 1197719002767 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1197719002768 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1197719002769 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1197719002770 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1197719002771 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1197719002772 Walker A/P-loop; other site 1197719002773 ATP binding site [chemical binding]; other site 1197719002774 Q-loop/lid; other site 1197719002775 ABC transporter signature motif; other site 1197719002776 Walker B; other site 1197719002777 D-loop; other site 1197719002778 H-loop/switch region; other site 1197719002779 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1197719002780 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1197719002781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1197719002782 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1197719002783 hypothetical protein; Provisional; Region: PRK11827 1197719002784 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1197719002785 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1197719002786 Ligand binding site; other site 1197719002787 oligomer interface; other site 1197719002788 hypothetical protein; Provisional; Region: PRK10593 1197719002789 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1197719002790 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1197719002791 putative active site [active] 1197719002792 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1197719002793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719002794 S-adenosylmethionine binding site [chemical binding]; other site 1197719002795 condesin subunit F; Provisional; Region: PRK05260 1197719002796 condesin subunit E; Provisional; Region: PRK05256 1197719002797 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1197719002798 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1197719002799 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1197719002800 murein L,D-transpeptidase; Provisional; Region: PRK10594 1197719002801 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1197719002802 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1197719002803 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1197719002804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1197719002805 Peptidase M15; Region: Peptidase_M15_3; cl01194 1197719002806 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1197719002807 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1197719002808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719002809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719002810 homodimer interface [polypeptide binding]; other site 1197719002811 catalytic residue [active] 1197719002812 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1197719002813 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1197719002814 trimer interface [polypeptide binding]; other site 1197719002815 eyelet of channel; other site 1197719002816 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1197719002817 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1197719002818 putative dimer interface [polypeptide binding]; other site 1197719002819 putative anticodon binding site; other site 1197719002820 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1197719002821 homodimer interface [polypeptide binding]; other site 1197719002822 motif 1; other site 1197719002823 motif 2; other site 1197719002824 active site 1197719002825 motif 3; other site 1197719002826 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1197719002827 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1197719002828 active site 1197719002829 MEKHLA domain; Region: MEKHLA; pfam08670 1197719002830 aminopeptidase N; Provisional; Region: pepN; PRK14015 1197719002831 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1197719002832 active site 1197719002833 Zn binding site [ion binding]; other site 1197719002834 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1197719002835 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1197719002836 quinone interaction residues [chemical binding]; other site 1197719002837 active site 1197719002838 catalytic residues [active] 1197719002839 FMN binding site [chemical binding]; other site 1197719002840 substrate binding site [chemical binding]; other site 1197719002841 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1197719002842 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1197719002843 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1197719002844 MOSC domain; Region: MOSC; pfam03473 1197719002845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1197719002846 catalytic loop [active] 1197719002847 iron binding site [ion binding]; other site 1197719002848 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1197719002849 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1197719002850 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1197719002851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719002852 S-adenosylmethionine binding site [chemical binding]; other site 1197719002853 ABC transporter ATPase component; Reviewed; Region: PRK11147 1197719002854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719002856 Walker A/P-loop; other site 1197719002857 Walker A/P-loop; other site 1197719002858 ATP binding site [chemical binding]; other site 1197719002859 ATP binding site [chemical binding]; other site 1197719002860 Q-loop/lid; other site 1197719002861 Q-loop/lid; other site 1197719002862 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719002863 ABC transporter signature motif; other site 1197719002864 Walker B; other site 1197719002865 D-loop; other site 1197719002866 ABC transporter; Region: ABC_tran_2; pfam12848 1197719002867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719002868 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1197719002869 Paraquat-inducible protein A; Region: PqiA; pfam04403 1197719002870 Paraquat-inducible protein A; Region: PqiA; pfam04403 1197719002871 paraquat-inducible protein B; Provisional; Region: PRK10807 1197719002872 mce related protein; Region: MCE; pfam02470 1197719002873 mce related protein; Region: MCE; pfam02470 1197719002874 mce related protein; Region: MCE; pfam02470 1197719002875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1197719002876 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1197719002877 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1197719002878 active site 1 [active] 1197719002879 dimer interface [polypeptide binding]; other site 1197719002880 active site 2 [active] 1197719002881 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1197719002882 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1197719002883 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1197719002884 outer membrane protein A; Reviewed; Region: PRK10808 1197719002885 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1197719002886 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1197719002887 ligand binding site [chemical binding]; other site 1197719002888 cell division inhibitor SulA; Region: sula; TIGR00623 1197719002889 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1197719002890 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1197719002891 TIGR01666 family membrane protein; Region: YCCS 1197719002892 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1197719002893 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1197719002894 Predicted membrane protein [Function unknown]; Region: COG3304 1197719002895 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1197719002896 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1197719002897 DNA helicase IV; Provisional; Region: helD; PRK11054 1197719002898 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1197719002899 Part of AAA domain; Region: AAA_19; pfam13245 1197719002900 Family description; Region: UvrD_C_2; pfam13538 1197719002901 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1197719002902 active site 1197719002903 dimer interfaces [polypeptide binding]; other site 1197719002904 catalytic residues [active] 1197719002905 hypothetical protein; Provisional; Region: PRK03641 1197719002906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1197719002907 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1197719002908 heat shock protein HspQ; Provisional; Region: PRK14129 1197719002909 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1197719002910 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1197719002911 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1197719002912 putative RNA binding site [nucleotide binding]; other site 1197719002913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719002914 S-adenosylmethionine binding site [chemical binding]; other site 1197719002915 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1197719002916 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1197719002917 substrate binding site [chemical binding]; other site 1197719002918 Cupin domain; Region: Cupin_2; cl17218 1197719002919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1197719002920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719002921 acylphosphatase; Provisional; Region: PRK14426 1197719002922 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1197719002923 sulfur transfer protein TusE; Provisional; Region: PRK11508 1197719002924 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1197719002925 YccA-like proteins; Region: YccA_like; cd10433 1197719002926 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719002927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719002928 active site 1197719002929 DNA binding site [nucleotide binding] 1197719002930 Int/Topo IB signature motif; other site 1197719002931 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 1197719002932 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1197719002933 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1197719002934 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1197719002935 Replication protein P; Region: Phage_lambda_P; pfam06992 1197719002936 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1197719002937 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1197719002938 DinI-like family; Region: DinI; cl11630 1197719002939 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1197719002940 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1197719002941 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1197719002942 ORF6N domain; Region: ORF6N; pfam10543 1197719002943 DinI-like family; Region: DinI; pfam06183 1197719002944 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1197719002945 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1197719002946 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1197719002947 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 1197719002948 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1197719002949 Predicted chitinase [General function prediction only]; Region: COG3179 1197719002950 catalytic residue [active] 1197719002951 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1197719002952 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1197719002953 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1197719002954 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1197719002955 Phage portal protein; Region: Phage_portal; pfam04860 1197719002956 Phage-related protein [Function unknown]; Region: COG4695 1197719002957 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1197719002958 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1197719002959 tandem repeat interface [polypeptide binding]; other site 1197719002960 oligomer interface [polypeptide binding]; other site 1197719002961 active site residues [active] 1197719002962 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1197719002963 Phage capsid family; Region: Phage_capsid; pfam05065 1197719002964 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1197719002965 oligomerization interface [polypeptide binding]; other site 1197719002966 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 1197719002967 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1197719002968 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1197719002969 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1197719002970 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1197719002971 Phage-related protein [Function unknown]; Region: gp18; COG4672 1197719002972 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1197719002973 MPN+ (JAMM) motif; other site 1197719002974 Zinc-binding site [ion binding]; other site 1197719002975 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1197719002976 NlpC/P60 family; Region: NLPC_P60; cl17555 1197719002977 Phage-related protein, tail component [Function unknown]; Region: COG4723 1197719002978 Phage-related protein, tail component [Function unknown]; Region: COG4733 1197719002979 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1197719002980 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1197719002981 Interdomain contacts; other site 1197719002982 Cytokine receptor motif; other site 1197719002983 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1197719002984 Fibronectin type III protein; Region: DUF3672; pfam12421 1197719002985 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1197719002986 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 1197719002987 SopA-like central domain; Region: SopA; pfam13981 1197719002988 SopA-like catalytic domain; Region: SopA_C; pfam13979 1197719002989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1197719002990 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1197719002991 Probable transposase; Region: OrfB_IS605; pfam01385 1197719002992 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1197719002993 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1197719002994 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1197719002995 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719002996 DNA binding site [nucleotide binding] 1197719002997 active site 1197719002998 Int/Topo IB signature motif; other site 1197719002999 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 1197719003000 SET domain; Region: SET; pfam00856 1197719003001 Type III secretion chaperone domain; Region: Chaperone_III; cl06729 1197719003002 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 1197719003003 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 1197719003004 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1197719003005 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1197719003006 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1197719003007 HAMP domain; Region: HAMP; pfam00672 1197719003008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719003009 dimer interface [polypeptide binding]; other site 1197719003010 phosphorylation site [posttranslational modification] 1197719003011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719003012 ATP binding site [chemical binding]; other site 1197719003013 Mg2+ binding site [ion binding]; other site 1197719003014 G-X-G motif; other site 1197719003015 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1197719003016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719003017 active site 1197719003018 phosphorylation site [posttranslational modification] 1197719003019 intermolecular recognition site; other site 1197719003020 dimerization interface [polypeptide binding]; other site 1197719003021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719003022 DNA binding site [nucleotide binding] 1197719003023 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1197719003024 active site 1197719003025 homotetramer interface [polypeptide binding]; other site 1197719003026 Flavin Reductases; Region: FlaRed; cl00801 1197719003027 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1197719003028 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1197719003029 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1197719003030 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1197719003031 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1197719003032 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1197719003033 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1197719003034 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1197719003035 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1197719003036 NAD binding site [chemical binding]; other site 1197719003037 catalytic residues [active] 1197719003038 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1197719003039 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1197719003040 putative active site [active] 1197719003041 putative metal binding site [ion binding]; other site 1197719003042 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1197719003043 putative substrate binding pocket [chemical binding]; other site 1197719003044 trimer interface [polypeptide binding]; other site 1197719003045 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1197719003046 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1197719003047 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1197719003048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003049 putative substrate translocation pore; other site 1197719003050 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1197719003051 Cupin domain; Region: Cupin_2; pfam07883 1197719003052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719003053 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1197719003054 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1197719003055 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1197719003056 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1197719003057 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1197719003058 HSP70 interaction site [polypeptide binding]; other site 1197719003059 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1197719003060 substrate binding site [polypeptide binding]; other site 1197719003061 dimer interface [polypeptide binding]; other site 1197719003062 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1197719003063 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1197719003064 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1197719003065 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1197719003066 DsbD alpha interface [polypeptide binding]; other site 1197719003067 catalytic residues [active] 1197719003068 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1197719003069 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1197719003070 catalytic residues [active] 1197719003071 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1197719003072 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1197719003073 catalytic residues [active] 1197719003074 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1197719003075 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1197719003076 catalytic core [active] 1197719003077 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1197719003078 hypothetical protein; Provisional; Region: PRK10174 1197719003079 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1197719003080 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1197719003081 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1197719003082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719003083 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1197719003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1197719003085 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1197719003086 Predicted transcriptional regulator [Transcription]; Region: COG3905 1197719003087 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1197719003088 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1197719003089 Glutamate binding site [chemical binding]; other site 1197719003090 NAD binding site [chemical binding]; other site 1197719003091 catalytic residues [active] 1197719003092 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1197719003093 Na binding site [ion binding]; other site 1197719003094 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1197719003095 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1197719003096 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1197719003097 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1197719003098 hypothetical protein; Provisional; Region: PRK10536 1197719003099 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1197719003100 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1197719003101 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1197719003102 putative ligand binding site [chemical binding]; other site 1197719003103 NAD binding site [chemical binding]; other site 1197719003104 dimerization interface [polypeptide binding]; other site 1197719003105 catalytic site [active] 1197719003106 putative hydrolase; Validated; Region: PRK09248 1197719003107 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1197719003108 active site 1197719003109 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1197719003110 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1197719003111 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1197719003112 curli assembly protein CsgF; Provisional; Region: PRK10050 1197719003113 curli assembly protein CsgE; Provisional; Region: PRK10386 1197719003114 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1197719003115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719003116 DNA binding residues [nucleotide binding] 1197719003117 dimerization interface [polypeptide binding]; other site 1197719003118 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1197719003119 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1197719003120 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1197719003121 major curlin subunit; Provisional; Region: csgA; PRK10051 1197719003122 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1197719003123 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1197719003124 putative ADP-ribose binding site [chemical binding]; other site 1197719003125 putative active site [active] 1197719003126 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1197719003127 PLD-like domain; Region: PLDc_2; pfam13091 1197719003128 putative active site [active] 1197719003129 catalytic site [active] 1197719003130 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1197719003131 PLD-like domain; Region: PLDc_2; pfam13091 1197719003132 putative active site [active] 1197719003133 catalytic site [active] 1197719003134 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1197719003135 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1197719003136 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1197719003137 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1197719003138 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1197719003139 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1197719003140 Ligand binding site; other site 1197719003141 DXD motif; other site 1197719003142 lipoprotein; Provisional; Region: PRK10175 1197719003143 secY/secA suppressor protein; Provisional; Region: PRK11467 1197719003144 drug efflux system protein MdtG; Provisional; Region: PRK09874 1197719003145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003146 putative substrate translocation pore; other site 1197719003147 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1197719003148 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1197719003149 putative acyl-acceptor binding pocket; other site 1197719003150 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1197719003151 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1197719003152 active site residue [active] 1197719003153 hypothetical protein; Provisional; Region: PRK03757 1197719003154 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1197719003155 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1197719003156 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1197719003157 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1197719003158 DNA damage-inducible protein I; Provisional; Region: PRK10597 1197719003159 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1197719003160 active site 1197719003161 substrate binding pocket [chemical binding]; other site 1197719003162 dimer interface [polypeptide binding]; other site 1197719003163 lipoprotein; Provisional; Region: PRK10598 1197719003164 glutaredoxin 2; Provisional; Region: PRK10387 1197719003165 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1197719003166 C-terminal domain interface [polypeptide binding]; other site 1197719003167 GSH binding site (G-site) [chemical binding]; other site 1197719003168 catalytic residues [active] 1197719003169 putative dimer interface [polypeptide binding]; other site 1197719003170 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1197719003171 N-terminal domain interface [polypeptide binding]; other site 1197719003172 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1197719003173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003174 putative substrate translocation pore; other site 1197719003175 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1197719003176 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1197719003177 hypothetical protein; Provisional; Region: PRK11239 1197719003178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1197719003179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1197719003180 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1197719003181 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1197719003182 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1197719003183 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1197719003184 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1197719003185 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1197719003186 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1197719003187 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1197719003188 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1197719003189 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1197719003190 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1197719003191 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1197719003192 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1197719003193 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1197719003194 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1197719003195 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1197719003196 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1197719003197 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1197719003198 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1197719003199 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1197719003200 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1197719003201 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1197719003202 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1197719003203 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1197719003204 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1197719003205 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1197719003206 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1197719003207 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1197719003208 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1197719003209 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1197719003210 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1197719003211 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1197719003212 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1197719003213 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1197719003214 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1197719003215 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1197719003216 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1197719003217 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1197719003218 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1197719003219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003220 putative substrate translocation pore; other site 1197719003221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719003222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719003223 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1197719003224 putative effector binding pocket; other site 1197719003225 dimerization interface [polypeptide binding]; other site 1197719003226 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1197719003227 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1197719003228 homodimer interface [polypeptide binding]; other site 1197719003229 oligonucleotide binding site [chemical binding]; other site 1197719003230 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1197719003231 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1197719003232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719003233 RNA binding surface [nucleotide binding]; other site 1197719003234 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1197719003235 active site 1197719003236 Maf-like protein; Region: Maf; pfam02545 1197719003237 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1197719003238 active site 1197719003239 dimer interface [polypeptide binding]; other site 1197719003240 hypothetical protein; Provisional; Region: PRK11193 1197719003241 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1197719003242 putative phosphate acyltransferase; Provisional; Region: PRK05331 1197719003243 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1197719003244 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1197719003245 dimer interface [polypeptide binding]; other site 1197719003246 active site 1197719003247 CoA binding pocket [chemical binding]; other site 1197719003248 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1197719003249 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1197719003250 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1197719003251 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1197719003252 NAD(P) binding site [chemical binding]; other site 1197719003253 homotetramer interface [polypeptide binding]; other site 1197719003254 homodimer interface [polypeptide binding]; other site 1197719003255 active site 1197719003256 acyl carrier protein; Provisional; Region: acpP; PRK00982 1197719003257 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1197719003258 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1197719003259 dimer interface [polypeptide binding]; other site 1197719003260 active site 1197719003261 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1197719003262 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1197719003263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719003264 catalytic residue [active] 1197719003265 conserved hypothetical protein, YceG family; Region: TIGR00247 1197719003266 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1197719003267 dimerization interface [polypeptide binding]; other site 1197719003268 thymidylate kinase; Validated; Region: tmk; PRK00698 1197719003269 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1197719003270 TMP-binding site; other site 1197719003271 ATP-binding site [chemical binding]; other site 1197719003272 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1197719003273 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1197719003274 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1197719003275 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1197719003276 active site 1197719003277 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1197719003278 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1197719003279 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1197719003280 active site turn [active] 1197719003281 phosphorylation site [posttranslational modification] 1197719003282 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1197719003283 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1197719003284 N-terminal plug; other site 1197719003285 ligand-binding site [chemical binding]; other site 1197719003286 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1197719003287 nucleotide binding site/active site [active] 1197719003288 HIT family signature motif; other site 1197719003289 catalytic residue [active] 1197719003290 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1197719003291 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1197719003292 putative dimer interface [polypeptide binding]; other site 1197719003293 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1197719003294 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1197719003295 substrate binding site [chemical binding]; other site 1197719003296 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1197719003297 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1197719003298 beta-hexosaminidase; Provisional; Region: PRK05337 1197719003299 hypothetical protein; Provisional; Region: PRK04940 1197719003300 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1197719003301 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719003302 hypothetical protein; Provisional; Region: PRK11280 1197719003303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1197719003304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719003305 RecT family; Region: RecT; cl04285 1197719003306 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719003307 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1197719003308 L,D-transpeptidase; Provisional; Region: PRK10190 1197719003309 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719003310 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1197719003311 transcription-repair coupling factor; Provisional; Region: PRK10689 1197719003312 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1197719003313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719003314 ATP binding site [chemical binding]; other site 1197719003315 putative Mg++ binding site [ion binding]; other site 1197719003316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719003317 nucleotide binding region [chemical binding]; other site 1197719003318 ATP-binding site [chemical binding]; other site 1197719003319 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1197719003320 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1197719003321 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1197719003322 FtsX-like permease family; Region: FtsX; pfam02687 1197719003323 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1197719003324 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1197719003325 Walker A/P-loop; other site 1197719003326 ATP binding site [chemical binding]; other site 1197719003327 Q-loop/lid; other site 1197719003328 ABC transporter signature motif; other site 1197719003329 Walker B; other site 1197719003330 D-loop; other site 1197719003331 H-loop/switch region; other site 1197719003332 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1197719003333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1197719003334 FtsX-like permease family; Region: FtsX; pfam02687 1197719003335 fructokinase; Reviewed; Region: PRK09557 1197719003336 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1197719003337 nucleotide binding site [chemical binding]; other site 1197719003338 NAD-dependent deacetylase; Provisional; Region: PRK00481 1197719003339 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1197719003340 NAD+ binding site [chemical binding]; other site 1197719003341 substrate binding site [chemical binding]; other site 1197719003342 Zn binding site [ion binding]; other site 1197719003343 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1197719003344 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1197719003345 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1197719003346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719003347 dimer interface [polypeptide binding]; other site 1197719003348 conserved gate region; other site 1197719003349 putative PBP binding loops; other site 1197719003350 ABC-ATPase subunit interface; other site 1197719003351 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1197719003352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719003353 dimer interface [polypeptide binding]; other site 1197719003354 conserved gate region; other site 1197719003355 putative PBP binding loops; other site 1197719003356 ABC-ATPase subunit interface; other site 1197719003357 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1197719003358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719003359 Walker A/P-loop; other site 1197719003360 ATP binding site [chemical binding]; other site 1197719003361 Q-loop/lid; other site 1197719003362 ABC transporter signature motif; other site 1197719003363 Walker B; other site 1197719003364 D-loop; other site 1197719003365 H-loop/switch region; other site 1197719003366 TOBE domain; Region: TOBE_2; pfam08402 1197719003367 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1197719003368 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1197719003369 metal binding site [ion binding]; metal-binding site 1197719003370 dimer interface [polypeptide binding]; other site 1197719003371 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1197719003372 Cupin-like domain; Region: Cupin_8; pfam13621 1197719003373 sensor protein PhoQ; Provisional; Region: PRK10815 1197719003374 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1197719003375 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1197719003376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719003377 ATP binding site [chemical binding]; other site 1197719003378 Mg2+ binding site [ion binding]; other site 1197719003379 G-X-G motif; other site 1197719003380 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1197719003381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719003382 active site 1197719003383 phosphorylation site [posttranslational modification] 1197719003384 intermolecular recognition site; other site 1197719003385 dimerization interface [polypeptide binding]; other site 1197719003386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719003387 DNA binding site [nucleotide binding] 1197719003388 adenylosuccinate lyase; Provisional; Region: PRK09285 1197719003389 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1197719003390 tetramer interface [polypeptide binding]; other site 1197719003391 active site 1197719003392 putative lysogenization regulator; Reviewed; Region: PRK00218 1197719003393 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1197719003394 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1197719003395 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1197719003396 nudix motif; other site 1197719003397 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1197719003398 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1197719003399 probable active site [active] 1197719003400 isocitrate dehydrogenase; Validated; Region: PRK07362 1197719003401 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1197719003402 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1197719003403 Beta-lactamase; Region: Beta-lactamase; pfam00144 1197719003404 Domain of unknown function DUF302; Region: DUF302; cl01364 1197719003405 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1197719003406 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1197719003407 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1197719003408 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1197719003409 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1197719003410 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1197719003411 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 1197719003412 putative catalytic site [active] 1197719003413 CdtC interface [polypeptide binding]; other site 1197719003414 heterotrimer interface [polypeptide binding]; other site 1197719003415 CdtA interface [polypeptide binding]; other site 1197719003416 putative metal binding site [ion binding]; other site 1197719003417 putative phosphate binding site [ion binding]; other site 1197719003418 Salmonella outer protein D; Region: SopD; cl14701 1197719003419 SET domain; Region: SET; pfam00856 1197719003420 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1197719003421 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 1197719003422 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 1197719003423 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1197719003424 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1197719003425 DinI-like family; Region: DinI; pfam06183 1197719003426 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1197719003427 putative sugar binding sites [chemical binding]; other site 1197719003428 Q-X-W motif; other site 1197719003429 Ricin-type beta-trefoil; Region: RICIN; smart00458 1197719003430 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1197719003431 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1197719003432 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1197719003433 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1197719003434 Leucine rich repeat; Region: LRR_8; pfam13855 1197719003435 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1197719003436 lysozyme inhibitor; Provisional; Region: PRK13791 1197719003437 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1197719003438 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1197719003439 putative dimer interface [polypeptide binding]; other site 1197719003440 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1197719003441 TRL-like protein family; Region: TRL; pfam13146 1197719003442 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1197719003443 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1197719003444 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1197719003445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719003446 dimer interface [polypeptide binding]; other site 1197719003447 conserved gate region; other site 1197719003448 putative PBP binding loops; other site 1197719003449 ABC-ATPase subunit interface; other site 1197719003450 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1197719003451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719003452 dimer interface [polypeptide binding]; other site 1197719003453 conserved gate region; other site 1197719003454 putative PBP binding loops; other site 1197719003455 ABC-ATPase subunit interface; other site 1197719003456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719003457 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1197719003458 Walker A/P-loop; other site 1197719003459 ATP binding site [chemical binding]; other site 1197719003460 Q-loop/lid; other site 1197719003461 ABC transporter signature motif; other site 1197719003462 Walker B; other site 1197719003463 D-loop; other site 1197719003464 H-loop/switch region; other site 1197719003465 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1197719003466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719003467 Walker A/P-loop; other site 1197719003468 ATP binding site [chemical binding]; other site 1197719003469 Q-loop/lid; other site 1197719003470 ABC transporter signature motif; other site 1197719003471 Walker B; other site 1197719003472 D-loop; other site 1197719003473 H-loop/switch region; other site 1197719003474 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1197719003475 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1197719003476 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1197719003477 dimerization interface [polypeptide binding]; other site 1197719003478 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1197719003479 aminoglycoside resistance protein; Provisional; Region: PRK13746 1197719003480 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1197719003481 active site 1197719003482 NTP binding site [chemical binding]; other site 1197719003483 metal binding triad [ion binding]; metal-binding site 1197719003484 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1197719003485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1197719003486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719003487 DNA binding residues [nucleotide binding] 1197719003488 transcriptional regulator MirA; Provisional; Region: PRK15043 1197719003489 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1197719003490 DNA binding residues [nucleotide binding] 1197719003491 dimer interface [polypeptide binding]; other site 1197719003492 Pleckstrin homology-like domain; Region: PH-like; cl17171 1197719003493 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1197719003494 chorismate mutase; Provisional; Region: PRK08055 1197719003495 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1197719003496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719003497 substrate binding pocket [chemical binding]; other site 1197719003498 membrane-bound complex binding site; other site 1197719003499 hinge residues; other site 1197719003500 leucine export protein LeuE; Provisional; Region: PRK10958 1197719003501 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1197719003502 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1197719003503 hypothetical protein; Provisional; Region: PRK10457 1197719003504 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1197719003505 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1197719003506 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1197719003507 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1197719003508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1197719003509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719003510 Predicted membrane protein [Function unknown]; Region: COG2707 1197719003511 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1197719003512 putative deacylase active site [active] 1197719003513 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1197719003514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719003515 metal binding site [ion binding]; metal-binding site 1197719003516 active site 1197719003517 I-site; other site 1197719003518 hypothetical protein; Provisional; Region: PRK05325 1197719003519 PrkA family serine protein kinase; Provisional; Region: PRK15455 1197719003520 AAA ATPase domain; Region: AAA_16; pfam13191 1197719003521 Walker A motif; other site 1197719003522 ATP binding site [chemical binding]; other site 1197719003523 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1197719003524 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1197719003525 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1197719003526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719003527 FeS/SAM binding site; other site 1197719003528 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1197719003529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719003530 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719003531 active site 1197719003532 catalytic tetrad [active] 1197719003533 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1197719003534 active site 1197719003535 phosphate binding residues; other site 1197719003536 catalytic residues [active] 1197719003537 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1197719003538 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1197719003539 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1197719003540 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1197719003541 SelR domain; Region: SelR; pfam01641 1197719003542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1197719003543 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1197719003544 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1197719003545 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1197719003546 putative NAD(P) binding site [chemical binding]; other site 1197719003547 catalytic Zn binding site [ion binding]; other site 1197719003548 structural Zn binding site [ion binding]; other site 1197719003549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003551 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1197719003552 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1197719003553 inhibitor binding site; inhibition site 1197719003554 catalytic Zn binding site [ion binding]; other site 1197719003555 structural Zn binding site [ion binding]; other site 1197719003556 NADP binding site [chemical binding]; other site 1197719003557 tetramer interface [polypeptide binding]; other site 1197719003558 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1197719003559 intersubunit interface [polypeptide binding]; other site 1197719003560 active site 1197719003561 zinc binding site [ion binding]; other site 1197719003562 Na+ binding site [ion binding]; other site 1197719003563 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1197719003564 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719003565 substrate binding site [chemical binding]; other site 1197719003566 ATP binding site [chemical binding]; other site 1197719003567 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719003568 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719003569 active site 1197719003570 catalytic tetrad [active] 1197719003571 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719003572 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1197719003573 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719003574 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1197719003575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003576 putative substrate translocation pore; other site 1197719003577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719003578 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1197719003579 Isochorismatase family; Region: Isochorismatase; pfam00857 1197719003580 catalytic triad [active] 1197719003581 metal binding site [ion binding]; metal-binding site 1197719003582 conserved cis-peptide bond; other site 1197719003583 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1197719003584 active site 1197719003585 homodimer interface [polypeptide binding]; other site 1197719003586 protease 4; Provisional; Region: PRK10949 1197719003587 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1197719003588 tandem repeat interface [polypeptide binding]; other site 1197719003589 oligomer interface [polypeptide binding]; other site 1197719003590 active site residues [active] 1197719003591 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1197719003592 tandem repeat interface [polypeptide binding]; other site 1197719003593 oligomer interface [polypeptide binding]; other site 1197719003594 active site residues [active] 1197719003595 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1197719003596 putative FMN binding site [chemical binding]; other site 1197719003597 selenophosphate synthetase; Provisional; Region: PRK00943 1197719003598 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1197719003599 dimerization interface [polypeptide binding]; other site 1197719003600 putative ATP binding site [chemical binding]; other site 1197719003601 DNA topoisomerase III; Provisional; Region: PRK07726 1197719003602 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1197719003603 active site 1197719003604 putative interdomain interaction site [polypeptide binding]; other site 1197719003605 putative metal-binding site [ion binding]; other site 1197719003606 putative nucleotide binding site [chemical binding]; other site 1197719003607 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1197719003608 domain I; other site 1197719003609 DNA binding groove [nucleotide binding] 1197719003610 phosphate binding site [ion binding]; other site 1197719003611 domain II; other site 1197719003612 domain III; other site 1197719003613 nucleotide binding site [chemical binding]; other site 1197719003614 catalytic site [active] 1197719003615 domain IV; other site 1197719003616 glutamate dehydrogenase; Provisional; Region: PRK09414 1197719003617 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1197719003618 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1197719003619 NAD(P) binding site [chemical binding]; other site 1197719003620 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1197719003621 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1197719003622 active site 1197719003623 8-oxo-dGMP binding site [chemical binding]; other site 1197719003624 nudix motif; other site 1197719003625 metal binding site [ion binding]; metal-binding site 1197719003626 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1197719003627 putative catalytic site [active] 1197719003628 putative phosphate binding site [ion binding]; other site 1197719003629 active site 1197719003630 metal binding site A [ion binding]; metal-binding site 1197719003631 DNA binding site [nucleotide binding] 1197719003632 putative AP binding site [nucleotide binding]; other site 1197719003633 putative metal binding site B [ion binding]; other site 1197719003634 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1197719003635 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1197719003636 inhibitor-cofactor binding pocket; inhibition site 1197719003637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719003638 catalytic residue [active] 1197719003639 arginine succinyltransferase; Provisional; Region: PRK10456 1197719003640 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1197719003641 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1197719003642 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1197719003643 NAD(P) binding site [chemical binding]; other site 1197719003644 catalytic residues [active] 1197719003645 succinylarginine dihydrolase; Provisional; Region: PRK13281 1197719003646 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1197719003647 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1197719003648 putative active site [active] 1197719003649 Zn binding site [ion binding]; other site 1197719003650 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1197719003651 dimer interface [polypeptide binding]; other site 1197719003652 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1197719003653 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1197719003654 GIY-YIG motif/motif A; other site 1197719003655 active site 1197719003656 catalytic site [active] 1197719003657 putative DNA binding site [nucleotide binding]; other site 1197719003658 metal binding site [ion binding]; metal-binding site 1197719003659 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1197719003660 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1197719003661 homodimer interface [polypeptide binding]; other site 1197719003662 NAD binding pocket [chemical binding]; other site 1197719003663 ATP binding pocket [chemical binding]; other site 1197719003664 Mg binding site [ion binding]; other site 1197719003665 active-site loop [active] 1197719003666 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1197719003667 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1197719003668 active site 1197719003669 P-loop; other site 1197719003670 phosphorylation site [posttranslational modification] 1197719003671 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1197719003672 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1197719003673 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1197719003674 methionine cluster; other site 1197719003675 active site 1197719003676 phosphorylation site [posttranslational modification] 1197719003677 metal binding site [ion binding]; metal-binding site 1197719003678 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1197719003679 Cupin domain; Region: Cupin_2; pfam07883 1197719003680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719003681 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1197719003682 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1197719003683 NAD binding site [chemical binding]; other site 1197719003684 sugar binding site [chemical binding]; other site 1197719003685 divalent metal binding site [ion binding]; other site 1197719003686 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1197719003687 dimer interface [polypeptide binding]; other site 1197719003688 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1197719003689 putative active site [active] 1197719003690 YdjC motif; other site 1197719003691 Mg binding site [ion binding]; other site 1197719003692 putative homodimer interface [polypeptide binding]; other site 1197719003693 hydroperoxidase II; Provisional; Region: katE; PRK11249 1197719003694 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1197719003695 tetramer interface [polypeptide binding]; other site 1197719003696 heme binding pocket [chemical binding]; other site 1197719003697 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1197719003698 domain interactions; other site 1197719003699 cell division modulator; Provisional; Region: PRK10113 1197719003700 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1197719003701 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1197719003702 inner membrane protein; Provisional; Region: PRK11648 1197719003703 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1197719003704 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1197719003705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719003706 motif II; other site 1197719003707 YniB-like protein; Region: YniB; pfam14002 1197719003708 Phosphotransferase enzyme family; Region: APH; pfam01636 1197719003709 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1197719003710 active site 1197719003711 ATP binding site [chemical binding]; other site 1197719003712 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1197719003713 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1197719003714 6-phosphofructokinase 2; Provisional; Region: PRK10294 1197719003715 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1197719003716 putative substrate binding site [chemical binding]; other site 1197719003717 putative ATP binding site [chemical binding]; other site 1197719003718 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1197719003719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 1197719003720 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1197719003721 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1197719003722 active site 1197719003723 substrate binding site [chemical binding]; other site 1197719003724 Mg2+ binding site [ion binding]; other site 1197719003725 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1197719003726 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1197719003727 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1197719003728 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1197719003729 active site 1197719003730 dimer interface [polypeptide binding]; other site 1197719003731 motif 1; other site 1197719003732 motif 2; other site 1197719003733 motif 3; other site 1197719003734 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1197719003735 anticodon binding site; other site 1197719003736 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1197719003737 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1197719003738 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1197719003739 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1197719003740 23S rRNA binding site [nucleotide binding]; other site 1197719003741 L21 binding site [polypeptide binding]; other site 1197719003742 L13 binding site [polypeptide binding]; other site 1197719003743 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1197719003744 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1197719003745 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1197719003746 dimer interface [polypeptide binding]; other site 1197719003747 motif 1; other site 1197719003748 active site 1197719003749 motif 2; other site 1197719003750 motif 3; other site 1197719003751 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1197719003752 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1197719003753 putative tRNA-binding site [nucleotide binding]; other site 1197719003754 B3/4 domain; Region: B3_4; pfam03483 1197719003755 tRNA synthetase B5 domain; Region: B5; smart00874 1197719003756 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1197719003757 dimer interface [polypeptide binding]; other site 1197719003758 motif 1; other site 1197719003759 motif 3; other site 1197719003760 motif 2; other site 1197719003761 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1197719003762 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1197719003763 IHF dimer interface [polypeptide binding]; other site 1197719003764 IHF - DNA interface [nucleotide binding]; other site 1197719003765 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1197719003766 tail protein; Provisional; Region: D; PHA02561 1197719003767 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1197719003768 Phage tail tube protein FII; Region: Phage_tube; pfam04985 1197719003769 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1197719003770 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 1197719003771 heterodimer interface [polypeptide binding]; other site 1197719003772 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1197719003773 Phage protein U [General function prediction only]; Region: COG3499 1197719003774 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1197719003775 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719003776 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719003777 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1197719003778 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1197719003779 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1197719003780 Baseplate J-like protein; Region: Baseplate_J; cl01294 1197719003781 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1197719003782 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1197719003783 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1197719003784 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1197719003785 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1197719003786 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1197719003787 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1197719003788 catalytic residues [active] 1197719003789 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1197719003790 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1197719003791 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1197719003792 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1197719003793 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1197719003794 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1197719003795 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1197719003796 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1197719003797 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1197719003798 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1197719003799 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1197719003800 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1197719003801 terminase ATPase subunit; Provisional; Region: P; PHA02535 1197719003802 terminase ATPase subunit; Provisional; Region: P; PHA02535 1197719003803 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1197719003804 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1197719003805 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 1197719003806 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1197719003807 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719003808 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719003809 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1197719003810 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1197719003811 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1197719003812 Baseplate J-like protein; Region: Baseplate_J; cl01294 1197719003813 Baseplate J-like protein; Region: Baseplate_J; cl01294 1197719003814 Baseplate J-like protein; Region: Baseplate_J; cl01294 1197719003815 Baseplate J-like protein; Region: Baseplate_J; cl01294 1197719003816 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1197719003817 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1197719003818 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1197719003819 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1197719003820 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1197719003821 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1197719003822 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1197719003823 catalytic residues [active] 1197719003824 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1197719003825 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1197719003826 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1197719003827 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1197719003828 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1197719003829 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1197719003830 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1197719003831 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1197719003832 terminase ATPase subunit; Provisional; Region: P; PHA02535 1197719003833 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1197719003834 Phage portal protein; Region: Phage_portal; pfam04860 1197719003835 type III secretion protein GogB; Provisional; Region: PRK15386 1197719003836 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1197719003837 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1197719003838 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1197719003839 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 1197719003840 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 1197719003841 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1197719003842 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1197719003843 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1197719003844 integrase; Provisional; Region: int; PHA02601 1197719003845 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719003846 active site 1197719003847 DNA binding site [nucleotide binding] 1197719003848 Int/Topo IB signature motif; other site 1197719003849 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1197719003850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719003851 ABC-ATPase subunit interface; other site 1197719003852 dimer interface [polypeptide binding]; other site 1197719003853 putative PBP binding regions; other site 1197719003854 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1197719003855 catalytic residues [active] 1197719003856 dimer interface [polypeptide binding]; other site 1197719003857 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1197719003858 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1197719003859 Walker A/P-loop; other site 1197719003860 ATP binding site [chemical binding]; other site 1197719003861 Q-loop/lid; other site 1197719003862 ABC transporter signature motif; other site 1197719003863 Walker B; other site 1197719003864 D-loop; other site 1197719003865 H-loop/switch region; other site 1197719003866 NlpC/P60 family; Region: NLPC_P60; pfam00877 1197719003867 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1197719003868 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1197719003869 hypothetical protein; Validated; Region: PRK00029 1197719003870 Hemin uptake protein hemP; Region: hemP; cl10043 1197719003871 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1197719003872 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1197719003873 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1197719003874 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1197719003875 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1197719003876 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1197719003877 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1197719003878 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1197719003879 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1197719003880 active site 1197719003881 catalytic residue [active] 1197719003882 dimer interface [polypeptide binding]; other site 1197719003883 putative inner membrane protein; Provisional; Region: PRK10983 1197719003884 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1197719003885 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1197719003886 FAD binding domain; Region: FAD_binding_4; pfam01565 1197719003887 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1197719003888 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1197719003889 CoenzymeA binding site [chemical binding]; other site 1197719003890 subunit interaction site [polypeptide binding]; other site 1197719003891 PHB binding site; other site 1197719003892 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1197719003893 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1197719003894 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1197719003895 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1197719003896 putative ABC transporter; Region: ycf24; CHL00085 1197719003897 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1197719003898 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1197719003899 Walker A/P-loop; other site 1197719003900 ATP binding site [chemical binding]; other site 1197719003901 Q-loop/lid; other site 1197719003902 ABC transporter signature motif; other site 1197719003903 Walker B; other site 1197719003904 D-loop; other site 1197719003905 H-loop/switch region; other site 1197719003906 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1197719003907 FeS assembly protein SufD; Region: sufD; TIGR01981 1197719003908 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1197719003909 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1197719003910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1197719003911 catalytic residue [active] 1197719003912 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1197719003913 L,D-transpeptidase; Provisional; Region: PRK10190 1197719003914 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719003915 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1197719003916 murein lipoprotein; Provisional; Region: PRK15396 1197719003917 pyruvate kinase; Provisional; Region: PRK09206 1197719003918 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1197719003919 domain interfaces; other site 1197719003920 active site 1197719003921 amino acid transporter; Region: 2A0306; TIGR00909 1197719003922 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1197719003923 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1197719003924 putative [Fe4-S4] binding site [ion binding]; other site 1197719003925 putative molybdopterin cofactor binding site [chemical binding]; other site 1197719003926 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1197719003927 putative molybdopterin cofactor binding site; other site 1197719003928 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1197719003929 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1197719003930 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1197719003931 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719003932 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 1197719003933 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1197719003934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1197719003935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719003936 dimer interface [polypeptide binding]; other site 1197719003937 phosphorylation site [posttranslational modification] 1197719003938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719003939 ATP binding site [chemical binding]; other site 1197719003940 Mg2+ binding site [ion binding]; other site 1197719003941 G-X-G motif; other site 1197719003942 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1197719003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719003944 active site 1197719003945 phosphorylation site [posttranslational modification] 1197719003946 intermolecular recognition site; other site 1197719003947 dimerization interface [polypeptide binding]; other site 1197719003948 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719003949 DNA binding residues [nucleotide binding] 1197719003950 dimerization interface [polypeptide binding]; other site 1197719003951 hypothetical protein; Provisional; Region: PRK10292 1197719003952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719003953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719003954 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1197719003955 putative effector binding pocket; other site 1197719003956 putative dimerization interface [polypeptide binding]; other site 1197719003957 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1197719003958 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1197719003959 putative NAD(P) binding site [chemical binding]; other site 1197719003960 putative substrate binding site [chemical binding]; other site 1197719003961 catalytic Zn binding site [ion binding]; other site 1197719003962 structural Zn binding site [ion binding]; other site 1197719003963 dimer interface [polypeptide binding]; other site 1197719003964 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1197719003965 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1197719003966 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1197719003967 transcriptional regulator MirA; Provisional; Region: PRK15043 1197719003968 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1197719003969 DNA binding residues [nucleotide binding] 1197719003970 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1197719003971 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1197719003972 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1197719003973 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1197719003974 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1197719003975 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1197719003976 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1197719003977 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1197719003978 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1197719003979 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1197719003980 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1197719003981 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1197719003982 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1197719003983 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1197719003984 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 1197719003985 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1197719003986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719003987 Walker A motif; other site 1197719003988 ATP binding site [chemical binding]; other site 1197719003989 Walker B motif; other site 1197719003990 arginine finger; other site 1197719003991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719003992 Walker A motif; other site 1197719003993 ATP binding site [chemical binding]; other site 1197719003994 Walker B motif; other site 1197719003995 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1197719003996 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1197719003997 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1197719003998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1197719003999 multidrug efflux protein; Reviewed; Region: PRK01766 1197719004000 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1197719004001 cation binding site [ion binding]; other site 1197719004002 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1197719004003 Lumazine binding domain; Region: Lum_binding; pfam00677 1197719004004 Lumazine binding domain; Region: Lum_binding; pfam00677 1197719004005 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1197719004006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1197719004007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719004008 S-adenosylmethionine binding site [chemical binding]; other site 1197719004009 putative transporter; Provisional; Region: PRK11043 1197719004010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004011 putative substrate translocation pore; other site 1197719004012 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1197719004013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719004014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719004015 dimerization interface [polypeptide binding]; other site 1197719004016 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1197719004017 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719004018 DNA binding site [nucleotide binding] 1197719004019 domain linker motif; other site 1197719004020 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1197719004021 dimerization interface [polypeptide binding]; other site 1197719004022 ligand binding site [chemical binding]; other site 1197719004023 superoxide dismutase; Provisional; Region: PRK10543 1197719004024 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1197719004025 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1197719004026 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1197719004027 NlpC/P60 family; Region: NLPC_P60; pfam00877 1197719004028 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1197719004029 putative GSH binding site [chemical binding]; other site 1197719004030 catalytic residues [active] 1197719004031 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1197719004032 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1197719004033 dimer interface [polypeptide binding]; other site 1197719004034 catalytic site [active] 1197719004035 putative active site [active] 1197719004036 putative substrate binding site [chemical binding]; other site 1197719004037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1197719004038 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1197719004039 dimer interface [polypeptide binding]; other site 1197719004040 active site 1197719004041 metal binding site [ion binding]; metal-binding site 1197719004042 glutathione binding site [chemical binding]; other site 1197719004043 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1197719004044 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1197719004045 FMN binding site [chemical binding]; other site 1197719004046 active site 1197719004047 substrate binding site [chemical binding]; other site 1197719004048 catalytic residue [active] 1197719004049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1197719004050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719004051 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1197719004052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719004053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719004054 active site 1197719004055 catalytic tetrad [active] 1197719004056 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1197719004057 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1197719004058 E-class dimer interface [polypeptide binding]; other site 1197719004059 P-class dimer interface [polypeptide binding]; other site 1197719004060 active site 1197719004061 Cu2+ binding site [ion binding]; other site 1197719004062 Zn2+ binding site [ion binding]; other site 1197719004063 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1197719004064 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1197719004065 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1197719004066 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719004067 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719004068 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1197719004069 transcriptional regulator SlyA; Provisional; Region: PRK03573 1197719004070 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1197719004071 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1197719004072 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1197719004073 lysozyme inhibitor; Provisional; Region: PRK11372 1197719004074 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1197719004075 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1197719004076 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1197719004077 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1197719004078 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1197719004079 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1197719004080 active site 1197719004081 HIGH motif; other site 1197719004082 dimer interface [polypeptide binding]; other site 1197719004083 KMSKS motif; other site 1197719004084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719004085 RNA binding surface [nucleotide binding]; other site 1197719004086 pyridoxamine kinase; Validated; Region: PRK05756 1197719004087 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1197719004088 dimer interface [polypeptide binding]; other site 1197719004089 pyridoxal binding site [chemical binding]; other site 1197719004090 ATP binding site [chemical binding]; other site 1197719004091 glutathionine S-transferase; Provisional; Region: PRK10542 1197719004092 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1197719004093 C-terminal domain interface [polypeptide binding]; other site 1197719004094 GSH binding site (G-site) [chemical binding]; other site 1197719004095 dimer interface [polypeptide binding]; other site 1197719004096 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1197719004097 dimer interface [polypeptide binding]; other site 1197719004098 N-terminal domain interface [polypeptide binding]; other site 1197719004099 substrate binding pocket (H-site) [chemical binding]; other site 1197719004100 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1197719004101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004102 putative substrate translocation pore; other site 1197719004103 POT family; Region: PTR2; pfam00854 1197719004104 endonuclease III; Provisional; Region: PRK10702 1197719004105 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1197719004106 minor groove reading motif; other site 1197719004107 helix-hairpin-helix signature motif; other site 1197719004108 substrate binding pocket [chemical binding]; other site 1197719004109 active site 1197719004110 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1197719004111 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1197719004112 electron transport complex protein RnfG; Validated; Region: PRK01908 1197719004113 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1197719004114 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1197719004115 SLBB domain; Region: SLBB; pfam10531 1197719004116 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1197719004117 electron transport complex protein RnfB; Provisional; Region: PRK05113 1197719004118 Putative Fe-S cluster; Region: FeS; cl17515 1197719004119 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719004120 electron transport complex protein RsxA; Provisional; Region: PRK05151 1197719004121 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1197719004122 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1197719004123 putative oxidoreductase; Provisional; Region: PRK11579 1197719004124 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1197719004125 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1197719004126 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1197719004127 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1197719004128 active site 1197719004129 purine riboside binding site [chemical binding]; other site 1197719004130 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1197719004131 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1197719004132 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1197719004133 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1197719004134 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1197719004135 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1197719004136 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1197719004137 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1197719004138 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1197719004139 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1197719004140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719004141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719004142 homodimer interface [polypeptide binding]; other site 1197719004143 catalytic residue [active] 1197719004144 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1197719004145 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1197719004146 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1197719004147 active site turn [active] 1197719004148 phosphorylation site [posttranslational modification] 1197719004149 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1197719004150 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719004151 DNA binding site [nucleotide binding] 1197719004152 domain linker motif; other site 1197719004153 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1197719004154 putative dimerization interface [polypeptide binding]; other site 1197719004155 putative ligand binding site [chemical binding]; other site 1197719004156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1197719004157 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1197719004158 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1197719004159 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1197719004160 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1197719004161 fumarate hydratase; Provisional; Region: PRK15389 1197719004162 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1197719004163 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1197719004164 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1197719004165 Class II fumarases; Region: Fumarase_classII; cd01362 1197719004166 active site 1197719004167 tetramer interface [polypeptide binding]; other site 1197719004168 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1197719004169 sensor protein RstB; Provisional; Region: PRK10604 1197719004170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719004171 dimerization interface [polypeptide binding]; other site 1197719004172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719004173 dimer interface [polypeptide binding]; other site 1197719004174 phosphorylation site [posttranslational modification] 1197719004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719004176 ATP binding site [chemical binding]; other site 1197719004177 Mg2+ binding site [ion binding]; other site 1197719004178 G-X-G motif; other site 1197719004179 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1197719004180 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1197719004181 active site 1197719004182 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1197719004183 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1197719004184 trimer interface [polypeptide binding]; other site 1197719004185 eyelet of channel; other site 1197719004186 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1197719004187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719004188 active site 1197719004189 phosphorylation site [posttranslational modification] 1197719004190 intermolecular recognition site; other site 1197719004191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719004192 DNA binding site [nucleotide binding] 1197719004193 GlpM protein; Region: GlpM; pfam06942 1197719004194 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1197719004195 Spore germination protein; Region: Spore_permease; cl17796 1197719004196 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719004197 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719004198 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719004199 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1197719004200 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1197719004201 ligand binding site [chemical binding]; other site 1197719004202 homodimer interface [polypeptide binding]; other site 1197719004203 NAD(P) binding site [chemical binding]; other site 1197719004204 trimer interface B [polypeptide binding]; other site 1197719004205 trimer interface A [polypeptide binding]; other site 1197719004206 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1197719004207 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1197719004208 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1197719004209 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1197719004210 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1197719004211 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1197719004212 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1197719004213 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1197719004214 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1197719004215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004216 putative substrate translocation pore; other site 1197719004217 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1197719004218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719004219 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1197719004220 dimerization interface [polypeptide binding]; other site 1197719004221 substrate binding pocket [chemical binding]; other site 1197719004222 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1197719004223 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1197719004224 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1197719004225 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1197719004226 AAA domain; Region: AAA_26; pfam13500 1197719004227 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1197719004228 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1197719004229 Cl- selectivity filter; other site 1197719004230 Cl- binding residues [ion binding]; other site 1197719004231 pore gating glutamate residue; other site 1197719004232 dimer interface [polypeptide binding]; other site 1197719004233 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1197719004234 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1197719004235 Walker A/P-loop; other site 1197719004236 ATP binding site [chemical binding]; other site 1197719004237 Q-loop/lid; other site 1197719004238 ABC transporter signature motif; other site 1197719004239 Walker B; other site 1197719004240 D-loop; other site 1197719004241 H-loop/switch region; other site 1197719004242 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1197719004243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004244 dimer interface [polypeptide binding]; other site 1197719004245 conserved gate region; other site 1197719004246 ABC-ATPase subunit interface; other site 1197719004247 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1197719004248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004249 dimer interface [polypeptide binding]; other site 1197719004250 conserved gate region; other site 1197719004251 putative PBP binding loops; other site 1197719004252 ABC-ATPase subunit interface; other site 1197719004253 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1197719004254 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1197719004255 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1197719004256 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719004257 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1197719004258 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1197719004259 putative [Fe4-S4] binding site [ion binding]; other site 1197719004260 putative molybdopterin cofactor binding site [chemical binding]; other site 1197719004261 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1197719004262 putative molybdopterin cofactor binding site; other site 1197719004263 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004264 molybdopterin cofactor binding site; other site 1197719004265 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1197719004266 putative molybdopterin cofactor binding site; other site 1197719004267 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004268 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1197719004269 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1197719004270 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1197719004271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719004272 Coenzyme A binding pocket [chemical binding]; other site 1197719004273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1197719004274 hypothetical protein; Provisional; Region: PRK13659 1197719004275 hypothetical protein; Provisional; Region: PRK02237 1197719004276 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1197719004277 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1197719004278 putative active site pocket [active] 1197719004279 putative metal binding site [ion binding]; other site 1197719004280 putative oxidoreductase; Provisional; Region: PRK10083 1197719004281 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1197719004282 putative NAD(P) binding site [chemical binding]; other site 1197719004283 catalytic Zn binding site [ion binding]; other site 1197719004284 structural Zn binding site [ion binding]; other site 1197719004285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004286 metabolite-proton symporter; Region: 2A0106; TIGR00883 1197719004287 putative substrate translocation pore; other site 1197719004288 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1197719004289 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1197719004290 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1197719004291 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1197719004292 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1197719004293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719004294 DNA-binding site [nucleotide binding]; DNA binding site 1197719004295 FCD domain; Region: FCD; pfam07729 1197719004296 malonic semialdehyde reductase; Provisional; Region: PRK10538 1197719004297 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1197719004298 putative NAD(P) binding site [chemical binding]; other site 1197719004299 homodimer interface [polypeptide binding]; other site 1197719004300 homotetramer interface [polypeptide binding]; other site 1197719004301 active site 1197719004302 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1197719004303 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1197719004304 active site 1197719004305 Zn binding site [ion binding]; other site 1197719004306 General stress protein [General function prediction only]; Region: GsiB; COG3729 1197719004307 hypothetical protein; Validated; Region: PRK03657 1197719004308 hypothetical protein; Provisional; Region: PRK10053 1197719004309 putative transporter; Provisional; Region: PRK10054 1197719004310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004311 putative substrate translocation pore; other site 1197719004312 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1197719004313 EamA-like transporter family; Region: EamA; pfam00892 1197719004314 EamA-like transporter family; Region: EamA; pfam00892 1197719004315 MarB protein; Region: MarB; pfam13999 1197719004316 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1197719004317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719004318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719004319 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1197719004320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1197719004321 inner membrane protein; Provisional; Region: PRK10995 1197719004322 putative arabinose transporter; Provisional; Region: PRK03545 1197719004323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004324 putative substrate translocation pore; other site 1197719004325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719004326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719004327 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1197719004328 putative dimerization interface [polypeptide binding]; other site 1197719004329 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1197719004330 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1197719004331 NAD(P) binding site [chemical binding]; other site 1197719004332 catalytic residues [active] 1197719004333 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1197719004334 glutaminase; Provisional; Region: PRK00971 1197719004335 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1197719004336 altronate oxidoreductase; Provisional; Region: PRK03643 1197719004337 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1197719004338 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1197719004339 Predicted membrane protein [Function unknown]; Region: COG3781 1197719004340 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1197719004341 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1197719004342 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1197719004343 trimer interface [polypeptide binding]; other site 1197719004344 eyelet of channel; other site 1197719004345 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1197719004346 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1197719004347 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1197719004348 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1197719004349 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1197719004350 Rubredoxin [Energy production and conversion]; Region: COG1773 1197719004351 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1197719004352 iron binding site [ion binding]; other site 1197719004353 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1197719004354 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1197719004355 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1197719004356 putative substrate-binding site; other site 1197719004357 nickel binding site [ion binding]; other site 1197719004358 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 1197719004359 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1197719004360 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1197719004361 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1197719004362 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1197719004363 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1197719004364 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1197719004365 active site 1197719004366 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1197719004367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719004368 DNA-binding site [nucleotide binding]; DNA binding site 1197719004369 FCD domain; Region: FCD; pfam07729 1197719004370 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1197719004371 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1197719004372 putative NAD(P) binding site [chemical binding]; other site 1197719004373 catalytic Zn binding site [ion binding]; other site 1197719004374 structural Zn binding site [ion binding]; other site 1197719004375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004376 D-galactonate transporter; Region: 2A0114; TIGR00893 1197719004377 putative substrate translocation pore; other site 1197719004378 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 1197719004379 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1197719004380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1197719004382 putative substrate translocation pore; other site 1197719004383 hypothetical protein; Provisional; Region: PRK06184 1197719004384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1197719004385 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1197719004386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1197719004387 putative DNA binding site [nucleotide binding]; other site 1197719004388 putative Zn2+ binding site [ion binding]; other site 1197719004389 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 1197719004390 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1197719004391 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1197719004392 homotrimer interaction site [polypeptide binding]; other site 1197719004393 putative active site [active] 1197719004394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1197719004395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1197719004396 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1197719004397 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1197719004398 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1197719004399 active site 1197719004400 catalytic site [active] 1197719004401 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1197719004402 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1197719004403 active site 1197719004404 catalytic site [active] 1197719004405 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1197719004406 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1197719004407 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1197719004408 catalytic site [active] 1197719004409 active site 1197719004410 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1197719004411 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1197719004412 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1197719004413 multidrug efflux protein; Reviewed; Region: PRK09579 1197719004414 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1197719004415 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719004416 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719004417 Predicted membrane protein [Function unknown]; Region: COG2259 1197719004418 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1197719004419 biofilm-dependent modulation protein; Provisional; Region: PRK11436 1197719004420 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1197719004421 malate dehydrogenase; Provisional; Region: PRK13529 1197719004422 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1197719004423 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1197719004424 NAD(P) binding site [chemical binding]; other site 1197719004425 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1197719004426 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1197719004427 NAD binding site [chemical binding]; other site 1197719004428 substrate binding site [chemical binding]; other site 1197719004429 catalytic Zn binding site [ion binding]; other site 1197719004430 tetramer interface [polypeptide binding]; other site 1197719004431 structural Zn binding site [ion binding]; other site 1197719004432 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1197719004433 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1197719004434 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1197719004435 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1197719004436 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004437 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004438 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1197719004439 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1197719004440 molybdopterin cofactor binding site; other site 1197719004441 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004442 aromatic amino acid exporter; Provisional; Region: PRK11689 1197719004443 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1197719004444 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1197719004445 trimer interface [polypeptide binding]; other site 1197719004446 eyelet of channel; other site 1197719004447 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1197719004448 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1197719004449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719004450 putative substrate translocation pore; other site 1197719004451 TetR family transcriptional regulator; Provisional; Region: PRK14996 1197719004452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719004453 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1197719004454 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1197719004455 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1197719004456 [4Fe-4S] binding site [ion binding]; other site 1197719004457 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004458 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004459 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719004460 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1197719004461 molybdopterin cofactor binding site; other site 1197719004462 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1197719004463 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1197719004464 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1197719004465 hypothetical protein; Provisional; Region: PRK10281 1197719004466 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1197719004467 transcriptional activator RhaS; Provisional; Region: PRK13503 1197719004468 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1197719004469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719004470 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1197719004471 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1197719004472 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1197719004473 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1197719004474 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1197719004475 trimer interface; other site 1197719004476 sugar binding site [chemical binding]; other site 1197719004477 L-asparagine permease; Provisional; Region: PRK15049 1197719004478 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1197719004479 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1197719004480 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1197719004481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1197719004482 N-terminal plug; other site 1197719004483 ligand-binding site [chemical binding]; other site 1197719004484 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1197719004485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719004486 DNA-binding site [nucleotide binding]; DNA binding site 1197719004487 FCD domain; Region: FCD; pfam07729 1197719004488 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1197719004489 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1197719004490 NAD(P) binding site [chemical binding]; other site 1197719004491 substrate binding site [chemical binding]; other site 1197719004492 dimer interface [polypeptide binding]; other site 1197719004493 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1197719004494 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1197719004495 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1197719004496 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 1197719004497 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1197719004498 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1197719004499 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1197719004500 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1197719004501 tetrameric interface [polypeptide binding]; other site 1197719004502 NAD binding site [chemical binding]; other site 1197719004503 catalytic residues [active] 1197719004504 substrate binding site [chemical binding]; other site 1197719004505 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1197719004506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719004507 DNA-binding site [nucleotide binding]; DNA binding site 1197719004508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719004509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719004510 homodimer interface [polypeptide binding]; other site 1197719004511 catalytic residue [active] 1197719004512 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 1197719004513 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1197719004514 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1197719004515 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1197719004516 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1197719004517 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1197719004518 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1197719004519 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1197719004520 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1197719004521 Peptidase family U32; Region: Peptidase_U32; pfam01136 1197719004522 Collagenase; Region: DUF3656; pfam12392 1197719004523 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1197719004524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719004525 non-specific DNA binding site [nucleotide binding]; other site 1197719004526 salt bridge; other site 1197719004527 sequence-specific DNA binding site [nucleotide binding]; other site 1197719004528 Cupin domain; Region: Cupin_2; pfam07883 1197719004529 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1197719004530 benzoate transporter; Region: benE; TIGR00843 1197719004531 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1197719004532 tellurite resistance protein TehB; Provisional; Region: PRK11207 1197719004533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719004534 S-adenosylmethionine binding site [chemical binding]; other site 1197719004535 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1197719004536 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1197719004537 gating phenylalanine in ion channel; other site 1197719004538 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1197719004539 putative trimer interface [polypeptide binding]; other site 1197719004540 putative CoA binding site [chemical binding]; other site 1197719004541 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1197719004542 putative trimer interface [polypeptide binding]; other site 1197719004543 putative CoA binding site [chemical binding]; other site 1197719004544 ribosomal-protein-L7/L12-serine acetyltransferase; Provisional; Region: PRK10151 1197719004545 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1197719004546 Coenzyme A binding pocket [chemical binding]; other site 1197719004547 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1197719004548 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1197719004549 oligomer interface [polypeptide binding]; other site 1197719004550 active site 1197719004551 metal binding site [ion binding]; metal-binding site 1197719004552 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1197719004553 active site 1197719004554 P-loop; other site 1197719004555 phosphorylation site [posttranslational modification] 1197719004556 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1197719004557 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1197719004558 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1197719004559 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719004560 active site 1197719004561 phosphorylation site [posttranslational modification] 1197719004562 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1197719004563 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1197719004564 substrate binding site [chemical binding]; other site 1197719004565 hexamer interface [polypeptide binding]; other site 1197719004566 metal binding site [ion binding]; metal-binding site 1197719004567 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719004568 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1197719004569 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719004570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1197719004571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719004572 Coenzyme A binding pocket [chemical binding]; other site 1197719004573 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1197719004574 teramer interface [polypeptide binding]; other site 1197719004575 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1197719004576 active site 1197719004577 FMN binding site [chemical binding]; other site 1197719004578 catalytic residues [active] 1197719004579 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1197719004580 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1197719004581 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1197719004582 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1197719004583 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1197719004584 substrate binding pocket [chemical binding]; other site 1197719004585 catalytic triad [active] 1197719004586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1197719004587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1197719004588 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1197719004589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719004590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719004591 dimerization interface [polypeptide binding]; other site 1197719004592 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1197719004593 dimer interface [polypeptide binding]; other site 1197719004594 ligand binding site [chemical binding]; other site 1197719004595 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1197719004596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719004597 dimerization interface [polypeptide binding]; other site 1197719004598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719004599 dimer interface [polypeptide binding]; other site 1197719004600 putative CheW interface [polypeptide binding]; other site 1197719004601 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1197719004602 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1197719004603 substrate binding site [chemical binding]; other site 1197719004604 catalytic Zn binding site [ion binding]; other site 1197719004605 NAD binding site [chemical binding]; other site 1197719004606 structural Zn binding site [ion binding]; other site 1197719004607 dimer interface [polypeptide binding]; other site 1197719004608 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1197719004609 putative metal binding site [ion binding]; other site 1197719004610 putative homodimer interface [polypeptide binding]; other site 1197719004611 putative homotetramer interface [polypeptide binding]; other site 1197719004612 putative homodimer-homodimer interface [polypeptide binding]; other site 1197719004613 putative allosteric switch controlling residues; other site 1197719004614 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1197719004615 hypothetical protein; Provisional; Region: PRK09951 1197719004616 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1197719004617 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1197719004618 active site 1197719004619 DNA binding site [nucleotide binding] 1197719004620 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1197719004621 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1197719004622 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1197719004623 Catalytic site [active] 1197719004624 Predicted membrane protein [Function unknown]; Region: COG3326 1197719004625 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1197719004626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719004627 substrate binding pocket [chemical binding]; other site 1197719004628 membrane-bound complex binding site; other site 1197719004629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719004630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004631 dimer interface [polypeptide binding]; other site 1197719004632 conserved gate region; other site 1197719004633 putative PBP binding loops; other site 1197719004634 ABC-ATPase subunit interface; other site 1197719004635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1197719004636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719004637 Walker A/P-loop; other site 1197719004638 ATP binding site [chemical binding]; other site 1197719004639 Q-loop/lid; other site 1197719004640 ABC transporter signature motif; other site 1197719004641 Walker B; other site 1197719004642 D-loop; other site 1197719004643 H-loop/switch region; other site 1197719004644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004645 dimer interface [polypeptide binding]; other site 1197719004646 conserved gate region; other site 1197719004647 putative PBP binding loops; other site 1197719004648 ABC-ATPase subunit interface; other site 1197719004649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719004650 S-adenosylmethionine binding site [chemical binding]; other site 1197719004651 cytochrome b561; Provisional; Region: PRK11513 1197719004652 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1197719004653 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1197719004654 putative active site [active] 1197719004655 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1197719004656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719004657 ATP binding site [chemical binding]; other site 1197719004658 putative Mg++ binding site [ion binding]; other site 1197719004659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719004660 nucleotide binding region [chemical binding]; other site 1197719004661 ATP-binding site [chemical binding]; other site 1197719004662 Helicase associated domain (HA2); Region: HA2; pfam04408 1197719004663 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1197719004664 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1197719004665 azoreductase; Reviewed; Region: PRK00170 1197719004666 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1197719004667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1197719004668 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1197719004669 hypothetical protein; Provisional; Region: PRK10695 1197719004670 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1197719004671 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1197719004672 putative ligand binding site [chemical binding]; other site 1197719004673 putative NAD binding site [chemical binding]; other site 1197719004674 catalytic site [active] 1197719004675 heat-inducible protein; Provisional; Region: PRK10449 1197719004676 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1197719004677 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1197719004678 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1197719004679 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1197719004680 dimer interface [polypeptide binding]; other site 1197719004681 PYR/PP interface [polypeptide binding]; other site 1197719004682 TPP binding site [chemical binding]; other site 1197719004683 substrate binding site [chemical binding]; other site 1197719004684 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1197719004685 Domain of unknown function; Region: EKR; smart00890 1197719004686 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1197719004687 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719004688 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1197719004689 TPP-binding site [chemical binding]; other site 1197719004690 dimer interface [polypeptide binding]; other site 1197719004691 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1197719004692 Ligand Binding Site [chemical binding]; other site 1197719004693 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1197719004694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719004695 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1197719004696 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1197719004697 Ligand Binding Site [chemical binding]; other site 1197719004698 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1197719004699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1197719004700 ATP binding site [chemical binding]; other site 1197719004701 Mg++ binding site [ion binding]; other site 1197719004702 motif III; other site 1197719004703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719004704 nucleotide binding region [chemical binding]; other site 1197719004705 ATP-binding site [chemical binding]; other site 1197719004706 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1197719004707 putative RNA binding site [nucleotide binding]; other site 1197719004708 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1197719004709 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1197719004710 Cl binding site [ion binding]; other site 1197719004711 oligomer interface [polypeptide binding]; other site 1197719004712 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1197719004713 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719004714 dimer interface [polypeptide binding]; other site 1197719004715 putative CheW interface [polypeptide binding]; other site 1197719004716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1197719004717 Smr domain; Region: Smr; pfam01713 1197719004718 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1197719004719 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1197719004720 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1197719004721 DNA binding site [nucleotide binding] 1197719004722 active site 1197719004723 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1197719004724 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1197719004725 ligand binding site [chemical binding]; other site 1197719004726 flexible hinge region; other site 1197719004727 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1197719004728 putative switch regulator; other site 1197719004729 non-specific DNA interactions [nucleotide binding]; other site 1197719004730 DNA binding site [nucleotide binding] 1197719004731 sequence specific DNA binding site [nucleotide binding]; other site 1197719004732 putative cAMP binding site [chemical binding]; other site 1197719004733 universal stress protein UspE; Provisional; Region: PRK11175 1197719004734 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1197719004735 Ligand Binding Site [chemical binding]; other site 1197719004736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1197719004737 Ligand Binding Site [chemical binding]; other site 1197719004738 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1197719004739 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1197719004740 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1197719004741 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1197719004742 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1197719004743 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1197719004744 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1197719004745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719004746 non-specific DNA binding site [nucleotide binding]; other site 1197719004747 salt bridge; other site 1197719004748 sequence-specific DNA binding site [nucleotide binding]; other site 1197719004749 Cupin domain; Region: Cupin_2; pfam07883 1197719004750 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1197719004751 B3/4 domain; Region: B3_4; pfam03483 1197719004752 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1197719004753 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1197719004754 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1197719004755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719004756 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1197719004757 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1197719004758 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1197719004759 putative NAD(P) binding site [chemical binding]; other site 1197719004760 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719004761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719004762 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1197719004763 putative effector binding pocket; other site 1197719004764 putative dimerization interface [polypeptide binding]; other site 1197719004765 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1197719004766 Temperature dependent protein affecting M2 dsRNA replication; Region: MKT1_N; pfam12247 1197719004767 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 1197719004768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719004769 binding surface 1197719004770 TPR repeat; Region: TPR_11; pfam13414 1197719004771 TPR motif; other site 1197719004772 Protein of unknown function (DUF560); Region: DUF560; pfam04575 1197719004773 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719004774 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1197719004775 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1197719004776 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1197719004777 Autotransporter beta-domain; Region: Autotransporter; smart00869 1197719004778 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1197719004779 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 1197719004780 putative active site [active] 1197719004781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1197719004782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719004783 Walker A/P-loop; other site 1197719004784 ATP binding site [chemical binding]; other site 1197719004785 Q-loop/lid; other site 1197719004786 ABC transporter signature motif; other site 1197719004787 Walker B; other site 1197719004788 D-loop; other site 1197719004789 H-loop/switch region; other site 1197719004790 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719004791 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 1197719004792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1197719004793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719004794 oxidoreductase; Provisional; Region: PRK12742 1197719004795 classical (c) SDRs; Region: SDR_c; cd05233 1197719004796 NAD(P) binding site [chemical binding]; other site 1197719004797 active site 1197719004798 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719004799 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1197719004800 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719004801 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1197719004802 substrate binding site [chemical binding]; other site 1197719004803 dimer interface [polypeptide binding]; other site 1197719004804 ATP binding site [chemical binding]; other site 1197719004805 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1197719004806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004807 dimer interface [polypeptide binding]; other site 1197719004808 conserved gate region; other site 1197719004809 ABC-ATPase subunit interface; other site 1197719004810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1197719004811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1197719004812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1197719004813 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1197719004814 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1197719004815 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1197719004816 Walker A/P-loop; other site 1197719004817 ATP binding site [chemical binding]; other site 1197719004818 Q-loop/lid; other site 1197719004819 ABC transporter signature motif; other site 1197719004820 Walker B; other site 1197719004821 D-loop; other site 1197719004822 H-loop/switch region; other site 1197719004823 TOBE domain; Region: TOBE_2; pfam08402 1197719004824 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719004825 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719004826 active site 1197719004827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719004828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719004829 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1197719004830 putative effector binding pocket; other site 1197719004831 putative dimerization interface [polypeptide binding]; other site 1197719004832 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1197719004833 NmrA-like family; Region: NmrA; pfam05368 1197719004834 NAD(P) binding site [chemical binding]; other site 1197719004835 active site lysine 1197719004836 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1197719004837 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1197719004838 peptide binding site [polypeptide binding]; other site 1197719004839 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1197719004840 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1197719004841 putative active site [active] 1197719004842 Zn binding site [ion binding]; other site 1197719004843 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1197719004844 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1197719004845 active site 1197719004846 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1197719004847 dimer interface [polypeptide binding]; other site 1197719004848 catalytic triad [active] 1197719004849 peroxidatic and resolving cysteines [active] 1197719004850 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1197719004851 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1197719004852 putative aromatic amino acid binding site; other site 1197719004853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719004854 Walker A motif; other site 1197719004855 ATP binding site [chemical binding]; other site 1197719004856 Walker B motif; other site 1197719004857 arginine finger; other site 1197719004858 hypothetical protein; Provisional; Region: PRK05415 1197719004859 TIGR01620 family protein; Region: hyp_HI0043 1197719004860 Predicted ATPase [General function prediction only]; Region: COG3106 1197719004861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1197719004862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719004863 DNA binding site [nucleotide binding] 1197719004864 domain linker motif; other site 1197719004865 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1197719004866 putative dimerization interface [polypeptide binding]; other site 1197719004867 putative ligand binding site [chemical binding]; other site 1197719004868 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1197719004869 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1197719004870 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1197719004871 Walker A/P-loop; other site 1197719004872 ATP binding site [chemical binding]; other site 1197719004873 Q-loop/lid; other site 1197719004874 ABC transporter signature motif; other site 1197719004875 Walker B; other site 1197719004876 D-loop; other site 1197719004877 H-loop/switch region; other site 1197719004878 TOBE domain; Region: TOBE_2; pfam08402 1197719004879 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1197719004880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719004881 motif II; other site 1197719004882 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1197719004883 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1197719004884 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1197719004885 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1197719004886 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1197719004887 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1197719004888 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1197719004889 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1197719004890 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1197719004891 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1197719004892 putative NAD(P) binding site [chemical binding]; other site 1197719004893 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1197719004894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004895 dimer interface [polypeptide binding]; other site 1197719004896 conserved gate region; other site 1197719004897 putative PBP binding loops; other site 1197719004898 ABC-ATPase subunit interface; other site 1197719004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004900 dimer interface [polypeptide binding]; other site 1197719004901 conserved gate region; other site 1197719004902 putative PBP binding loops; other site 1197719004903 ABC-ATPase subunit interface; other site 1197719004904 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1197719004905 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1197719004906 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1197719004907 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1197719004908 active site 1197719004909 homodimer interface [polypeptide binding]; other site 1197719004910 catalytic site [active] 1197719004911 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 1197719004912 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1197719004913 phage shock protein C; Region: phageshock_pspC; TIGR02978 1197719004914 phage shock protein B; Provisional; Region: pspB; PRK09458 1197719004915 phage shock protein PspA; Provisional; Region: PRK10698 1197719004916 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1197719004917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719004918 Walker A motif; other site 1197719004919 ATP binding site [chemical binding]; other site 1197719004920 Walker B motif; other site 1197719004921 arginine finger; other site 1197719004922 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1197719004923 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1197719004924 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1197719004925 peptide binding site [polypeptide binding]; other site 1197719004926 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1197719004927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004928 dimer interface [polypeptide binding]; other site 1197719004929 conserved gate region; other site 1197719004930 putative PBP binding loops; other site 1197719004931 ABC-ATPase subunit interface; other site 1197719004932 Predicted chitinase [General function prediction only]; Region: COG3179 1197719004933 catalytic residue [active] 1197719004934 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1197719004935 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1197719004936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1197719004937 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1197719004938 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1197719004939 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719004940 metal binding site [ion binding]; metal-binding site 1197719004941 active site 1197719004942 I-site; other site 1197719004943 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1197719004944 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1197719004945 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1197719004946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719004947 dimer interface [polypeptide binding]; other site 1197719004948 conserved gate region; other site 1197719004949 putative PBP binding loops; other site 1197719004950 ABC-ATPase subunit interface; other site 1197719004951 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1197719004952 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719004953 Walker A/P-loop; other site 1197719004954 ATP binding site [chemical binding]; other site 1197719004955 Q-loop/lid; other site 1197719004956 ABC transporter signature motif; other site 1197719004957 Walker B; other site 1197719004958 D-loop; other site 1197719004959 H-loop/switch region; other site 1197719004960 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1197719004961 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1197719004962 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719004963 Walker A/P-loop; other site 1197719004964 ATP binding site [chemical binding]; other site 1197719004965 Q-loop/lid; other site 1197719004966 ABC transporter signature motif; other site 1197719004967 Walker B; other site 1197719004968 D-loop; other site 1197719004969 H-loop/switch region; other site 1197719004970 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1197719004971 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1197719004972 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1197719004973 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1197719004974 NAD binding site [chemical binding]; other site 1197719004975 homotetramer interface [polypeptide binding]; other site 1197719004976 homodimer interface [polypeptide binding]; other site 1197719004977 substrate binding site [chemical binding]; other site 1197719004978 active site 1197719004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1197719004980 exoribonuclease II; Provisional; Region: PRK05054 1197719004981 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1197719004982 RNB domain; Region: RNB; pfam00773 1197719004983 S1 RNA binding domain; Region: S1; pfam00575 1197719004984 RNase II stability modulator; Provisional; Region: PRK10060 1197719004985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719004986 putative active site [active] 1197719004987 heme pocket [chemical binding]; other site 1197719004988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719004989 metal binding site [ion binding]; metal-binding site 1197719004990 active site 1197719004991 I-site; other site 1197719004992 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719004993 hypothetical protein; Provisional; Region: PRK13658 1197719004994 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719004995 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1197719004996 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719004997 lipoprotein; Provisional; Region: PRK10540 1197719004998 translation initiation factor Sui1; Validated; Region: PRK06824 1197719004999 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1197719005000 putative rRNA binding site [nucleotide binding]; other site 1197719005001 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1197719005002 active site 1197719005003 dimer interface [polypeptide binding]; other site 1197719005004 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1197719005005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719005006 binding surface 1197719005007 TPR motif; other site 1197719005008 Predicted membrane protein [Function unknown]; Region: COG3771 1197719005009 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1197719005010 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1197719005011 active site 1197719005012 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1197719005013 dimerization interface [polypeptide binding]; other site 1197719005014 active site 1197719005015 aconitate hydratase; Validated; Region: PRK09277 1197719005016 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1197719005017 substrate binding site [chemical binding]; other site 1197719005018 ligand binding site [chemical binding]; other site 1197719005019 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1197719005020 substrate binding site [chemical binding]; other site 1197719005021 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1197719005022 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1197719005023 substrate binding site [chemical binding]; other site 1197719005024 putative dimerization interface [polypeptide binding]; other site 1197719005025 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1197719005026 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1197719005027 active site 1197719005028 interdomain interaction site; other site 1197719005029 putative metal-binding site [ion binding]; other site 1197719005030 nucleotide binding site [chemical binding]; other site 1197719005031 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1197719005032 domain I; other site 1197719005033 DNA binding groove [nucleotide binding] 1197719005034 phosphate binding site [ion binding]; other site 1197719005035 domain II; other site 1197719005036 domain III; other site 1197719005037 nucleotide binding site [chemical binding]; other site 1197719005038 catalytic site [active] 1197719005039 domain IV; other site 1197719005040 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1197719005041 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1197719005042 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1197719005043 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1197719005044 hypothetical protein; Provisional; Region: PRK11037 1197719005045 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1197719005046 putative inner membrane peptidase; Provisional; Region: PRK11778 1197719005047 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1197719005048 tandem repeat interface [polypeptide binding]; other site 1197719005049 oligomer interface [polypeptide binding]; other site 1197719005050 active site residues [active] 1197719005051 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1197719005052 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1197719005053 NADP binding site [chemical binding]; other site 1197719005054 homodimer interface [polypeptide binding]; other site 1197719005055 active site 1197719005056 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1197719005057 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1197719005058 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1197719005059 homodimer interface [polypeptide binding]; other site 1197719005060 Walker A motif; other site 1197719005061 ATP binding site [chemical binding]; other site 1197719005062 hydroxycobalamin binding site [chemical binding]; other site 1197719005063 Walker B motif; other site 1197719005064 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1197719005065 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719005066 RNA binding surface [nucleotide binding]; other site 1197719005067 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1197719005068 probable active site [active] 1197719005069 hypothetical protein; Provisional; Region: PRK11630 1197719005070 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1197719005071 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1197719005072 active site 1197719005073 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1197719005074 anthranilate synthase component I; Provisional; Region: PRK13564 1197719005075 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1197719005076 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1197719005077 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1197719005078 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1197719005079 glutamine binding [chemical binding]; other site 1197719005080 catalytic triad [active] 1197719005081 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1197719005082 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1197719005083 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1197719005084 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1197719005085 active site 1197719005086 ribulose/triose binding site [chemical binding]; other site 1197719005087 phosphate binding site [ion binding]; other site 1197719005088 substrate (anthranilate) binding pocket [chemical binding]; other site 1197719005089 product (indole) binding pocket [chemical binding]; other site 1197719005090 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1197719005091 active site 1197719005092 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1197719005093 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1197719005094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719005095 catalytic residue [active] 1197719005096 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1197719005097 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1197719005098 substrate binding site [chemical binding]; other site 1197719005099 active site 1197719005100 catalytic residues [active] 1197719005101 heterodimer interface [polypeptide binding]; other site 1197719005102 General stress protein [General function prediction only]; Region: GsiB; COG3729 1197719005103 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1197719005104 dimerization interface [polypeptide binding]; other site 1197719005105 metal binding site [ion binding]; metal-binding site 1197719005106 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1197719005107 dinuclear metal binding motif [ion binding]; other site 1197719005108 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1197719005109 dimanganese center [ion binding]; other site 1197719005110 outer membrane protein W; Provisional; Region: PRK10959 1197719005111 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1197719005112 hypothetical protein; Provisional; Region: PRK02868 1197719005113 intracellular septation protein A; Reviewed; Region: PRK00259 1197719005114 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1197719005115 transport protein TonB; Provisional; Region: PRK10819 1197719005116 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1197719005117 YciI-like protein; Reviewed; Region: PRK11370 1197719005118 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1197719005119 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1197719005120 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1197719005121 putative active site [active] 1197719005122 catalytic site [active] 1197719005123 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1197719005124 putative active site [active] 1197719005125 catalytic site [active] 1197719005126 dsDNA-mimic protein; Reviewed; Region: PRK05094 1197719005127 Ion transport protein; Region: Ion_trans; pfam00520 1197719005128 Ion channel; Region: Ion_trans_2; pfam07885 1197719005129 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1197719005130 Double zinc ribbon; Region: DZR; pfam12773 1197719005131 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1197719005132 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719005133 Walker A/P-loop; other site 1197719005134 ATP binding site [chemical binding]; other site 1197719005135 Q-loop/lid; other site 1197719005136 ABC transporter signature motif; other site 1197719005137 Walker B; other site 1197719005138 D-loop; other site 1197719005139 H-loop/switch region; other site 1197719005140 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1197719005141 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1197719005142 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719005143 Walker A/P-loop; other site 1197719005144 ATP binding site [chemical binding]; other site 1197719005145 Q-loop/lid; other site 1197719005146 ABC transporter signature motif; other site 1197719005147 Walker B; other site 1197719005148 D-loop; other site 1197719005149 H-loop/switch region; other site 1197719005150 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1197719005151 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1197719005152 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1197719005153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719005154 dimer interface [polypeptide binding]; other site 1197719005155 conserved gate region; other site 1197719005156 ABC-ATPase subunit interface; other site 1197719005157 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1197719005158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719005159 dimer interface [polypeptide binding]; other site 1197719005160 conserved gate region; other site 1197719005161 putative PBP binding loops; other site 1197719005162 ABC-ATPase subunit interface; other site 1197719005163 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1197719005164 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1197719005165 peptide binding site [polypeptide binding]; other site 1197719005166 hypothetical protein; Provisional; Region: PRK11111 1197719005167 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1197719005168 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1197719005169 putative catalytic cysteine [active] 1197719005170 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1197719005171 putative active site [active] 1197719005172 metal binding site [ion binding]; metal-binding site 1197719005173 thymidine kinase; Provisional; Region: PRK04296 1197719005174 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1197719005175 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1197719005176 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1197719005177 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1197719005178 active site 1197719005179 tetramer interface; other site 1197719005180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719005181 active site 1197719005182 response regulator of RpoS; Provisional; Region: PRK10693 1197719005183 phosphorylation site [posttranslational modification] 1197719005184 intermolecular recognition site; other site 1197719005185 dimerization interface [polypeptide binding]; other site 1197719005186 hypothetical protein; Provisional; Region: PRK10279 1197719005187 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1197719005188 active site 1197719005189 nucleophile elbow; other site 1197719005190 hypothetical protein; Provisional; Region: PRK01617 1197719005191 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1197719005192 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1197719005193 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1197719005194 putative active site [active] 1197719005195 putative substrate binding site [chemical binding]; other site 1197719005196 putative cosubstrate binding site; other site 1197719005197 catalytic site [active] 1197719005198 Predicted ATPase [General function prediction only]; Region: COG3911 1197719005199 AAA domain; Region: AAA_28; pfam13521 1197719005200 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1197719005201 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1197719005202 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1197719005203 4Fe-4S binding domain; Region: Fer4; cl02805 1197719005204 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1197719005205 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1197719005206 [4Fe-4S] binding site [ion binding]; other site 1197719005207 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719005208 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719005209 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719005210 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1197719005211 molybdopterin cofactor binding site; other site 1197719005212 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1197719005213 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1197719005214 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1197719005215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719005216 dimerization interface [polypeptide binding]; other site 1197719005217 Histidine kinase; Region: HisKA_3; pfam07730 1197719005218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719005219 ATP binding site [chemical binding]; other site 1197719005220 Mg2+ binding site [ion binding]; other site 1197719005221 G-X-G motif; other site 1197719005222 transcriptional regulator NarL; Provisional; Region: PRK10651 1197719005223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719005224 active site 1197719005225 phosphorylation site [posttranslational modification] 1197719005226 intermolecular recognition site; other site 1197719005227 dimerization interface [polypeptide binding]; other site 1197719005228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719005229 DNA binding residues [nucleotide binding] 1197719005230 dimerization interface [polypeptide binding]; other site 1197719005231 putative invasin; Provisional; Region: PRK10177 1197719005232 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1197719005233 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1197719005234 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1197719005235 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1197719005236 putative active site pocket [active] 1197719005237 dimerization interface [polypeptide binding]; other site 1197719005238 putative catalytic residue [active] 1197719005239 cation transport regulator; Reviewed; Region: chaB; PRK09582 1197719005240 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1197719005241 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1197719005242 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 1197719005243 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1197719005244 hypothetical protein; Provisional; Region: PRK10941 1197719005245 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1197719005246 hypothetical protein; Provisional; Region: PRK10278 1197719005247 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1197719005248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719005249 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1197719005250 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1197719005251 RF-1 domain; Region: RF-1; pfam00472 1197719005252 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1197719005253 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1197719005254 tRNA; other site 1197719005255 putative tRNA binding site [nucleotide binding]; other site 1197719005256 putative NADP binding site [chemical binding]; other site 1197719005257 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1197719005258 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1197719005259 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1197719005260 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1197719005261 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1197719005262 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1197719005263 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1197719005264 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1197719005265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719005266 active site 1197719005267 putative transporter; Provisional; Region: PRK11660 1197719005268 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1197719005269 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1197719005270 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1197719005271 hypothetical protein; Provisional; Region: PRK10692 1197719005272 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1197719005273 putative active site [active] 1197719005274 catalytic residue [active] 1197719005275 GTP-binding protein YchF; Reviewed; Region: PRK09601 1197719005276 YchF GTPase; Region: YchF; cd01900 1197719005277 G1 box; other site 1197719005278 GTP/Mg2+ binding site [chemical binding]; other site 1197719005279 Switch I region; other site 1197719005280 G2 box; other site 1197719005281 Switch II region; other site 1197719005282 G3 box; other site 1197719005283 G4 box; other site 1197719005284 G5 box; other site 1197719005285 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1197719005286 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 1197719005287 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1197719005288 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1197719005289 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1197719005290 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1197719005291 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1197719005292 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1197719005293 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1197719005294 putative substrate-binding site; other site 1197719005295 nickel binding site [ion binding]; other site 1197719005296 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1197719005297 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1197719005298 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1197719005299 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1197719005300 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1197719005301 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1197719005302 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1197719005303 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1197719005304 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1197719005305 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1197719005306 NAD(P) binding site [chemical binding]; other site 1197719005307 trehalase; Provisional; Region: treA; PRK13271 1197719005308 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1197719005309 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1197719005310 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1197719005311 Flagellar regulator YcgR; Region: YcgR; pfam07317 1197719005312 PilZ domain; Region: PilZ; pfam07238 1197719005313 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1197719005314 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719005315 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719005316 catalytic residue [active] 1197719005317 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1197719005318 dimer interface [polypeptide binding]; other site 1197719005319 catalytic triad [active] 1197719005320 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1197719005321 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1197719005322 TrkA-C domain; Region: TrkA_C; pfam02080 1197719005323 Transporter associated domain; Region: CorC_HlyC; smart01091 1197719005324 alanine racemase; Reviewed; Region: dadX; PRK03646 1197719005325 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1197719005326 active site 1197719005327 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1197719005328 substrate binding site [chemical binding]; other site 1197719005329 catalytic residues [active] 1197719005330 dimer interface [polypeptide binding]; other site 1197719005331 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1197719005332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719005333 SpoVR family protein; Provisional; Region: PRK11767 1197719005334 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1197719005335 fatty acid metabolism regulator; Provisional; Region: PRK04984 1197719005336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719005337 DNA-binding site [nucleotide binding]; DNA binding site 1197719005338 FadR C-terminal domain; Region: FadR_C; pfam07840 1197719005339 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1197719005340 transmembrane helices; other site 1197719005341 disulfide bond formation protein B; Provisional; Region: PRK01749 1197719005342 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1197719005343 GnsA/GnsB family; Region: GnsAB; pfam08178 1197719005344 hypothetical protein; Provisional; Region: PRK05170 1197719005345 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1197719005346 hypothetical protein; Provisional; Region: PRK10691 1197719005347 YcgL domain; Region: YcgL; cl01189 1197719005348 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1197719005349 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1197719005350 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1197719005351 cell division inhibitor MinD; Provisional; Region: PRK10818 1197719005352 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1197719005353 Switch I; other site 1197719005354 Switch II; other site 1197719005355 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1197719005356 ribonuclease D; Provisional; Region: PRK10829 1197719005357 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1197719005358 catalytic site [active] 1197719005359 putative active site [active] 1197719005360 putative substrate binding site [chemical binding]; other site 1197719005361 HRDC domain; Region: HRDC; cl02578 1197719005362 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1197719005363 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1197719005364 acyl-activating enzyme (AAE) consensus motif; other site 1197719005365 putative AMP binding site [chemical binding]; other site 1197719005366 putative active site [active] 1197719005367 putative CoA binding site [chemical binding]; other site 1197719005368 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1197719005369 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1197719005370 Glycoprotease family; Region: Peptidase_M22; pfam00814 1197719005371 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1197719005372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1197719005373 DEAD_2; Region: DEAD_2; pfam06733 1197719005374 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1197719005375 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1197719005376 homotrimer interaction site [polypeptide binding]; other site 1197719005377 putative active site [active] 1197719005378 hypothetical protein; Provisional; Region: PRK05114 1197719005379 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1197719005380 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1197719005381 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1197719005382 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1197719005383 putative active site [active] 1197719005384 putative CoA binding site [chemical binding]; other site 1197719005385 nudix motif; other site 1197719005386 metal binding site [ion binding]; metal-binding site 1197719005387 L-serine deaminase; Provisional; Region: PRK15023 1197719005388 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1197719005389 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1197719005390 phage resistance protein; Provisional; Region: PRK10551 1197719005391 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1197719005392 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719005393 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1197719005394 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1197719005395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1197719005396 Transporter associated domain; Region: CorC_HlyC; smart01091 1197719005397 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1197719005398 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1197719005399 active pocket/dimerization site; other site 1197719005400 active site 1197719005401 phosphorylation site [posttranslational modification] 1197719005402 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1197719005403 active site 1197719005404 phosphorylation site [posttranslational modification] 1197719005405 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1197719005406 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1197719005407 hypothetical protein; Provisional; Region: PRK02913 1197719005408 hypothetical protein; Provisional; Region: PRK11469 1197719005409 Domain of unknown function DUF; Region: DUF204; pfam02659 1197719005410 Domain of unknown function DUF; Region: DUF204; pfam02659 1197719005411 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1197719005412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719005413 S-adenosylmethionine binding site [chemical binding]; other site 1197719005414 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1197719005415 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1197719005416 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1197719005417 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1197719005418 DNA-binding site [nucleotide binding]; DNA binding site 1197719005419 RNA-binding motif; other site 1197719005420 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1197719005421 YebO-like protein; Region: YebO; pfam13974 1197719005422 PhoPQ regulatory protein; Provisional; Region: PRK10299 1197719005423 YobH-like protein; Region: YobH; pfam13996 1197719005424 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1197719005425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1197719005426 dimerization interface [polypeptide binding]; other site 1197719005427 putative Zn2+ binding site [ion binding]; other site 1197719005428 putative DNA binding site [nucleotide binding]; other site 1197719005429 Bacterial transcriptional regulator; Region: IclR; pfam01614 1197719005430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719005431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1197719005432 putative substrate translocation pore; other site 1197719005433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719005434 heat shock protein HtpX; Provisional; Region: PRK05457 1197719005435 carboxy-terminal protease; Provisional; Region: PRK11186 1197719005436 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1197719005437 protein binding site [polypeptide binding]; other site 1197719005438 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1197719005439 Catalytic dyad [active] 1197719005440 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1197719005441 ProP expression regulator; Provisional; Region: PRK04950 1197719005442 ProQ/FINO family; Region: ProQ; pfam04352 1197719005443 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1197719005444 GAF domain; Region: GAF_2; pfam13185 1197719005445 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1197719005446 Paraquat-inducible protein A; Region: PqiA; pfam04403 1197719005447 Paraquat-inducible protein A; Region: PqiA; pfam04403 1197719005448 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1197719005449 mce related protein; Region: MCE; pfam02470 1197719005450 mce related protein; Region: MCE; pfam02470 1197719005451 mce related protein; Region: MCE; pfam02470 1197719005452 mce related protein; Region: MCE; pfam02470 1197719005453 mce related protein; Region: MCE; pfam02470 1197719005454 mce related protein; Region: MCE; pfam02470 1197719005455 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1197719005456 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1197719005457 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1197719005458 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1197719005459 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1197719005460 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1197719005461 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1197719005462 active site 1197719005463 metal binding site [ion binding]; metal-binding site 1197719005464 SopE GEF domain; Region: SopE_GEF; pfam07487 1197719005465 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1197719005466 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1197719005467 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1197719005468 hypothetical protein; Provisional; Region: PRK10301 1197719005469 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1197719005470 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1197719005471 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1197719005472 exodeoxyribonuclease X; Provisional; Region: PRK07983 1197719005473 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1197719005474 active site 1197719005475 catalytic site [active] 1197719005476 substrate binding site [chemical binding]; other site 1197719005477 protease 2; Provisional; Region: PRK10115 1197719005478 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1197719005479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1197719005480 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1197719005481 putative metal binding site [ion binding]; other site 1197719005482 hypothetical protein; Provisional; Region: PRK13680 1197719005483 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1197719005484 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1197719005485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1197719005486 ATP-grasp domain; Region: ATP-grasp; pfam02222 1197719005487 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1197719005488 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1197719005489 active site 1197719005490 intersubunit interface [polypeptide binding]; other site 1197719005491 catalytic residue [active] 1197719005492 phosphogluconate dehydratase; Validated; Region: PRK09054 1197719005493 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1197719005494 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1197719005495 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1197719005496 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1197719005497 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1197719005498 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1197719005499 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1197719005500 putative active site [active] 1197719005501 pyruvate kinase; Provisional; Region: PRK05826 1197719005502 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1197719005503 domain interfaces; other site 1197719005504 active site 1197719005505 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1197719005506 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1197719005507 putative acyl-acceptor binding pocket; other site 1197719005508 putative peptidase; Provisional; Region: PRK11649 1197719005509 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1197719005510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719005511 Peptidase family M23; Region: Peptidase_M23; pfam01551 1197719005512 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1197719005513 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1197719005514 metal binding site [ion binding]; metal-binding site 1197719005515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719005516 ABC transporter; Region: ABC_tran; pfam00005 1197719005517 Q-loop/lid; other site 1197719005518 ABC transporter signature motif; other site 1197719005519 Walker B; other site 1197719005520 D-loop; other site 1197719005521 H-loop/switch region; other site 1197719005522 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1197719005523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719005524 ABC-ATPase subunit interface; other site 1197719005525 dimer interface [polypeptide binding]; other site 1197719005526 putative PBP binding regions; other site 1197719005527 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1197719005528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719005529 Walker A motif; other site 1197719005530 ATP binding site [chemical binding]; other site 1197719005531 Walker B motif; other site 1197719005532 arginine finger; other site 1197719005533 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1197719005534 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1197719005535 RuvA N terminal domain; Region: RuvA_N; pfam01330 1197719005536 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1197719005537 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1197719005538 active site 1197719005539 putative DNA-binding cleft [nucleotide binding]; other site 1197719005540 dimer interface [polypeptide binding]; other site 1197719005541 hypothetical protein; Validated; Region: PRK00110 1197719005542 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1197719005543 nudix motif; other site 1197719005544 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1197719005545 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1197719005546 dimer interface [polypeptide binding]; other site 1197719005547 anticodon binding site; other site 1197719005548 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1197719005549 homodimer interface [polypeptide binding]; other site 1197719005550 motif 1; other site 1197719005551 active site 1197719005552 motif 2; other site 1197719005553 GAD domain; Region: GAD; pfam02938 1197719005554 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1197719005555 active site 1197719005556 motif 3; other site 1197719005557 Isochorismatase family; Region: Isochorismatase; pfam00857 1197719005558 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1197719005559 catalytic triad [active] 1197719005560 conserved cis-peptide bond; other site 1197719005561 hypothetical protein; Provisional; Region: PRK09951 1197719005562 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1197719005563 DNA binding site [nucleotide binding] 1197719005564 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1197719005565 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1197719005566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1197719005567 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1197719005568 active site 1197719005569 catalytic residues [active] 1197719005570 DNA binding site [nucleotide binding] 1197719005571 Int/Topo IB signature motif; other site 1197719005572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719005573 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719005574 Y-family of DNA polymerases; Region: PolY; cl12025 1197719005575 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1197719005576 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1197719005577 Catalytic site [active] 1197719005578 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1197719005579 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1197719005580 catalytic residues [active] 1197719005581 catalytic nucleophile [active] 1197719005582 Presynaptic Site I dimer interface [polypeptide binding]; other site 1197719005583 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1197719005584 Synaptic Flat tetramer interface [polypeptide binding]; other site 1197719005585 Synaptic Site I dimer interface [polypeptide binding]; other site 1197719005586 DNA binding site [nucleotide binding] 1197719005587 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1197719005588 DNA-binding interface [nucleotide binding]; DNA binding site 1197719005589 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1197719005590 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719005591 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719005592 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1197719005593 Baseplate J-like protein; Region: Baseplate_J; pfam04865 1197719005594 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1197719005595 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 1197719005596 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1197719005597 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1197719005598 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1197719005599 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1197719005600 Phage tail tube protein FII; Region: Phage_tube; cl01390 1197719005601 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1197719005602 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 1197719005603 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1197719005604 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1197719005605 oligomer interface [polypeptide binding]; other site 1197719005606 Clp protease; Region: CLP_protease; pfam00574 1197719005607 active site residues [active] 1197719005608 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1197719005609 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1197719005610 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1197719005611 ParB-like nuclease domain; Region: ParBc; pfam02195 1197719005612 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1197719005613 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1197719005614 Predicted chitinase [General function prediction only]; Region: COG3179 1197719005615 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1197719005616 Antitermination protein; Region: Antiterm; pfam03589 1197719005617 Protein of unknown function (DUF1356); Region: DUF1356; pfam07092 1197719005618 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1197719005619 Antitermination protein; Region: Antiterm; pfam03589 1197719005620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1197719005621 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1197719005622 Toprim domain; Region: Toprim_3; pfam13362 1197719005623 active site 1197719005624 metal binding site [ion binding]; metal-binding site 1197719005625 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1197719005626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719005627 ATP binding site [chemical binding]; other site 1197719005628 putative Mg++ binding site [ion binding]; other site 1197719005629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719005630 nucleotide binding region [chemical binding]; other site 1197719005631 ATP-binding site [chemical binding]; other site 1197719005632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1197719005633 salt bridge; other site 1197719005634 Predicted transcriptional regulator [Transcription]; Region: COG2932 1197719005635 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1197719005636 Catalytic site [active] 1197719005637 ORF6N domain; Region: ORF6N; pfam10543 1197719005638 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1197719005639 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1197719005640 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1197719005641 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1197719005642 Int/Topo IB signature motif; other site 1197719005643 Protein of unknown function DUF72; Region: DUF72; cl00777 1197719005644 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1197719005645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719005646 S-adenosylmethionine binding site [chemical binding]; other site 1197719005647 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1197719005648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719005649 S-adenosylmethionine binding site [chemical binding]; other site 1197719005650 copper homeostasis protein CutC; Provisional; Region: PRK11572 1197719005651 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1197719005652 putative metal binding site [ion binding]; other site 1197719005653 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1197719005654 arginyl-tRNA synthetase; Region: argS; TIGR00456 1197719005655 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1197719005656 active site 1197719005657 HIGH motif; other site 1197719005658 KMSK motif region; other site 1197719005659 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1197719005660 tRNA binding surface [nucleotide binding]; other site 1197719005661 anticodon binding site; other site 1197719005662 penicillin-binding protein 2; Provisional; Region: PRK10795 1197719005663 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1197719005664 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1197719005665 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1197719005666 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1197719005667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719005668 Flagellar protein FlhE; Region: FlhE; pfam06366 1197719005669 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1197719005670 FHIPEP family; Region: FHIPEP; pfam00771 1197719005671 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1197719005672 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1197719005673 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1197719005674 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1197719005675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719005676 active site 1197719005677 phosphorylation site [posttranslational modification] 1197719005678 intermolecular recognition site; other site 1197719005679 dimerization interface [polypeptide binding]; other site 1197719005680 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1197719005681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719005682 active site 1197719005683 phosphorylation site [posttranslational modification] 1197719005684 intermolecular recognition site; other site 1197719005685 dimerization interface [polypeptide binding]; other site 1197719005686 CheB methylesterase; Region: CheB_methylest; pfam01339 1197719005687 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1197719005688 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1197719005689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719005690 S-adenosylmethionine binding site [chemical binding]; other site 1197719005691 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1197719005692 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1197719005693 dimer interface [polypeptide binding]; other site 1197719005694 ligand binding site [chemical binding]; other site 1197719005695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719005696 dimerization interface [polypeptide binding]; other site 1197719005697 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719005698 dimer interface [polypeptide binding]; other site 1197719005699 putative CheW interface [polypeptide binding]; other site 1197719005700 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1197719005701 putative CheA interaction surface; other site 1197719005702 chemotaxis protein CheA; Provisional; Region: PRK10547 1197719005703 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1197719005704 putative binding surface; other site 1197719005705 active site 1197719005706 CheY binding; Region: CheY-binding; pfam09078 1197719005707 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1197719005708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719005709 ATP binding site [chemical binding]; other site 1197719005710 Mg2+ binding site [ion binding]; other site 1197719005711 G-X-G motif; other site 1197719005712 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1197719005713 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1197719005714 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1197719005715 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1197719005716 ligand binding site [chemical binding]; other site 1197719005717 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1197719005718 flagellar motor protein MotA; Validated; Region: PRK09110 1197719005719 transcriptional activator FlhC; Provisional; Region: PRK12722 1197719005720 transcriptional activator FlhD; Provisional; Region: PRK02909 1197719005721 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1197719005722 Ligand Binding Site [chemical binding]; other site 1197719005723 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1197719005724 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1197719005725 active site 1197719005726 homotetramer interface [polypeptide binding]; other site 1197719005727 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1197719005728 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1197719005729 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1197719005730 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1197719005731 TM-ABC transporter signature motif; other site 1197719005732 DJ-1 family protein; Region: not_thiJ; TIGR01383 1197719005733 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1197719005734 conserved cys residue [active] 1197719005735 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1197719005736 Ferritin-like domain; Region: Ferritin; pfam00210 1197719005737 ferroxidase diiron center [ion binding]; other site 1197719005738 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1197719005739 YecR-like lipoprotein; Region: YecR; pfam13992 1197719005740 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1197719005741 Ferritin-like domain; Region: Ferritin; pfam00210 1197719005742 ferroxidase diiron center [ion binding]; other site 1197719005743 probable metal-binding protein; Region: matur_matur; TIGR03853 1197719005744 tyrosine transporter TyrP; Provisional; Region: PRK15132 1197719005745 aromatic amino acid transport protein; Region: araaP; TIGR00837 1197719005746 hypothetical protein; Provisional; Region: PRK10396 1197719005747 yecA family protein; Region: ygfB_yecA; TIGR02292 1197719005748 SEC-C motif; Region: SEC-C; pfam02810 1197719005749 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1197719005750 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 1197719005751 NlpC/P60 family; Region: NLPC_P60; cl17555 1197719005752 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1197719005753 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1197719005754 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1197719005755 GIY-YIG motif/motif A; other site 1197719005756 active site 1197719005757 catalytic site [active] 1197719005758 putative DNA binding site [nucleotide binding]; other site 1197719005759 metal binding site [ion binding]; metal-binding site 1197719005760 UvrB/uvrC motif; Region: UVR; pfam02151 1197719005761 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1197719005762 Helix-hairpin-helix motif; Region: HHH; pfam00633 1197719005763 response regulator; Provisional; Region: PRK09483 1197719005764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719005765 active site 1197719005766 phosphorylation site [posttranslational modification] 1197719005767 intermolecular recognition site; other site 1197719005768 dimerization interface [polypeptide binding]; other site 1197719005769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719005770 DNA binding residues [nucleotide binding] 1197719005771 dimerization interface [polypeptide binding]; other site 1197719005772 hypothetical protein; Provisional; Region: PRK10613 1197719005773 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1197719005774 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1197719005775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719005776 DNA binding residues [nucleotide binding] 1197719005777 dimerization interface [polypeptide binding]; other site 1197719005778 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1197719005779 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1197719005780 Walker A/P-loop; other site 1197719005781 ATP binding site [chemical binding]; other site 1197719005782 Q-loop/lid; other site 1197719005783 ABC transporter signature motif; other site 1197719005784 Walker B; other site 1197719005785 D-loop; other site 1197719005786 H-loop/switch region; other site 1197719005787 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1197719005788 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719005789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719005790 dimer interface [polypeptide binding]; other site 1197719005791 conserved gate region; other site 1197719005792 putative PBP binding loops; other site 1197719005793 ABC-ATPase subunit interface; other site 1197719005794 D-cysteine desulfhydrase; Validated; Region: PRK03910 1197719005795 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1197719005796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719005797 catalytic residue [active] 1197719005798 cystine transporter subunit; Provisional; Region: PRK11260 1197719005799 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719005800 substrate binding pocket [chemical binding]; other site 1197719005801 membrane-bound complex binding site; other site 1197719005802 hinge residues; other site 1197719005803 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1197719005804 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1197719005805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1197719005806 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1197719005807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1197719005808 DNA binding residues [nucleotide binding] 1197719005809 flagellin; Validated; Region: PRK08026 1197719005810 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1197719005811 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1197719005812 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1197719005813 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1197719005814 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1197719005815 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1197719005816 flagellar protein FliS; Validated; Region: fliS; PRK05685 1197719005817 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1197719005818 lipoprotein; Provisional; Region: PRK10397 1197719005819 putative inner membrane protein; Provisional; Region: PRK11099 1197719005820 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1197719005821 CPxP motif; other site 1197719005822 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1197719005823 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1197719005824 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1197719005825 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1197719005826 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1197719005827 FliG C-terminal domain; Region: FliG_C; pfam01706 1197719005828 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1197719005829 Flagellar assembly protein FliH; Region: FliH; pfam02108 1197719005830 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1197719005831 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1197719005832 Walker A motif/ATP binding site; other site 1197719005833 Walker B motif; other site 1197719005834 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1197719005835 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1197719005836 flagellar hook-length control protein; Provisional; Region: PRK10118 1197719005837 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1197719005838 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1197719005839 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1197719005840 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1197719005841 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1197719005842 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1197719005843 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1197719005844 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1197719005845 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1197719005846 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1197719005847 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1197719005848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719005849 DNA binding residues [nucleotide binding] 1197719005850 dimerization interface [polypeptide binding]; other site 1197719005851 hypothetical protein; Provisional; Region: PRK10708 1197719005852 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1197719005853 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1197719005854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719005855 active site 1197719005856 motif I; other site 1197719005857 motif II; other site 1197719005858 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1197719005859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719005860 metal binding site [ion binding]; metal-binding site 1197719005861 active site 1197719005862 I-site; other site 1197719005863 Uncharacterized small protein [Function unknown]; Region: COG5475 1197719005864 hypothetical protein; Provisional; Region: PRK10062 1197719005865 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1197719005866 EamA-like transporter family; Region: EamA; pfam00892 1197719005867 EamA-like transporter family; Region: EamA; pfam00892 1197719005868 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1197719005869 additional DNA contacts [nucleotide binding]; other site 1197719005870 mismatch recognition site; other site 1197719005871 active site 1197719005872 zinc binding site [ion binding]; other site 1197719005873 DNA intercalation site [nucleotide binding]; other site 1197719005874 DNA cytosine methylase; Provisional; Region: PRK10458 1197719005875 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1197719005876 cofactor binding site; other site 1197719005877 DNA binding site [nucleotide binding] 1197719005878 substrate interaction site [chemical binding]; other site 1197719005879 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1197719005880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1197719005881 Zn2+ binding site [ion binding]; other site 1197719005882 Mg2+ binding site [ion binding]; other site 1197719005883 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1197719005884 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1197719005885 trimer interface [polypeptide binding]; other site 1197719005886 eyelet of channel; other site 1197719005887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719005888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1197719005889 substrate binding pocket [chemical binding]; other site 1197719005890 membrane-bound complex binding site; other site 1197719005891 hinge residues; other site 1197719005892 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719005893 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719005894 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719005895 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719005896 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1197719005897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719005898 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719005899 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719005900 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1197719005901 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1197719005902 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719005903 VRR-NUC domain; Region: VRR_NUC; cl17748 1197719005904 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1197719005905 Peptidase family C69; Region: Peptidase_C69; cl17793 1197719005906 PerC transcriptional activator; Region: PerC; pfam06069 1197719005907 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1197719005908 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1197719005909 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1197719005910 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1197719005911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719005912 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1197719005913 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719005914 VRR-NUC domain; Region: VRR_NUC; cl17748 1197719005915 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1197719005916 AMP nucleosidase; Provisional; Region: PRK08292 1197719005917 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1197719005918 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1197719005919 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719005920 RHS Repeat; Region: RHS_repeat; cl11982 1197719005921 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719005922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1197719005923 active site 1197719005924 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1197719005925 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1197719005926 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719005927 RHS Repeat; Region: RHS_repeat; pfam05593 1197719005928 RHS Repeat; Region: RHS_repeat; cl11982 1197719005929 RHS Repeat; Region: RHS_repeat; pfam05593 1197719005930 RHS Repeat; Region: RHS_repeat; pfam05593 1197719005931 RHS Repeat; Region: RHS_repeat; cl11982 1197719005932 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719005933 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1197719005934 MATE family multidrug exporter; Provisional; Region: PRK10189 1197719005935 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1197719005936 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1197719005937 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 1197719005938 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1197719005939 hypothetical protein; Provisional; Region: PRK05423 1197719005940 Predicted membrane protein [Function unknown]; Region: COG1289 1197719005941 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1197719005942 DNA gyrase inhibitor; Provisional; Region: PRK10016 1197719005943 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1197719005944 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1197719005945 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1197719005946 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1197719005947 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1197719005948 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1197719005949 4Fe-4S binding domain; Region: Fer4; cl02805 1197719005950 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1197719005951 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1197719005952 putative [Fe4-S4] binding site [ion binding]; other site 1197719005953 putative molybdopterin cofactor binding site [chemical binding]; other site 1197719005954 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1197719005955 putative molybdopterin cofactor binding site; other site 1197719005956 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 1197719005957 Transposase; Region: HTH_Tnp_1; pfam01527 1197719005958 putative transposase OrfB; Reviewed; Region: PHA02517 1197719005959 HTH-like domain; Region: HTH_21; pfam13276 1197719005960 Integrase core domain; Region: rve_3; pfam13683 1197719005961 exonuclease I; Provisional; Region: sbcB; PRK11779 1197719005962 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1197719005963 active site 1197719005964 catalytic site [active] 1197719005965 substrate binding site [chemical binding]; other site 1197719005966 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1197719005967 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1197719005968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719005969 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1197719005970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719005971 dimerization interface [polypeptide binding]; other site 1197719005972 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1197719005973 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1197719005974 putative NAD(P) binding site [chemical binding]; other site 1197719005975 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1197719005976 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1197719005977 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1197719005978 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1197719005979 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1197719005980 NAD binding site [chemical binding]; other site 1197719005981 dimerization interface [polypeptide binding]; other site 1197719005982 product binding site; other site 1197719005983 substrate binding site [chemical binding]; other site 1197719005984 zinc binding site [ion binding]; other site 1197719005985 catalytic residues [active] 1197719005986 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1197719005987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719005988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719005989 homodimer interface [polypeptide binding]; other site 1197719005990 catalytic residue [active] 1197719005991 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1197719005992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719005993 active site 1197719005994 motif I; other site 1197719005995 motif II; other site 1197719005996 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1197719005997 putative active site pocket [active] 1197719005998 4-fold oligomerization interface [polypeptide binding]; other site 1197719005999 metal binding residues [ion binding]; metal-binding site 1197719006000 3-fold/trimer interface [polypeptide binding]; other site 1197719006001 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1197719006002 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1197719006003 putative active site [active] 1197719006004 oxyanion strand; other site 1197719006005 catalytic triad [active] 1197719006006 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1197719006007 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1197719006008 catalytic residues [active] 1197719006009 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1197719006010 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1197719006011 substrate binding site [chemical binding]; other site 1197719006012 glutamase interaction surface [polypeptide binding]; other site 1197719006013 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1197719006014 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1197719006015 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1197719006016 metal binding site [ion binding]; metal-binding site 1197719006017 chain length determinant protein WzzB; Provisional; Region: PRK15471 1197719006018 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1197719006019 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1197719006020 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1197719006021 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1197719006022 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1197719006023 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1197719006024 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1197719006025 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1197719006026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1197719006027 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1197719006028 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1197719006029 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1197719006030 active site 1197719006031 homodimer interface [polypeptide binding]; other site 1197719006032 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 1197719006033 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1197719006034 putative NAD(P) binding site [chemical binding]; other site 1197719006035 active site 1197719006036 putative substrate binding site [chemical binding]; other site 1197719006037 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1197719006038 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1197719006039 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1197719006040 NAD(P) binding site [chemical binding]; other site 1197719006041 homodimer interface [polypeptide binding]; other site 1197719006042 substrate binding site [chemical binding]; other site 1197719006043 active site 1197719006044 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1197719006045 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 1197719006046 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1197719006047 substrate binding site [chemical binding]; other site 1197719006048 glutamase interaction surface [polypeptide binding]; other site 1197719006049 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1197719006050 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1197719006051 putative active site [active] 1197719006052 oxyanion strand; other site 1197719006053 catalytic triad [active] 1197719006054 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1197719006055 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 1197719006056 Ligand Binding Site [chemical binding]; other site 1197719006057 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1197719006058 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1197719006059 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1197719006060 active site 1197719006061 homodimer interface [polypeptide binding]; other site 1197719006062 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1197719006063 ligand binding site; other site 1197719006064 tetramer interface; other site 1197719006065 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1197719006066 active site 1197719006067 catalytic triad [active] 1197719006068 oxyanion hole [active] 1197719006069 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1197719006070 NeuB family; Region: NeuB; pfam03102 1197719006071 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1197719006072 NeuB binding interface [polypeptide binding]; other site 1197719006073 putative substrate binding site [chemical binding]; other site 1197719006074 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1197719006075 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1197719006076 active site 1197719006077 tetramer interface; other site 1197719006078 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 1197719006079 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1197719006080 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1197719006081 putative ADP-binding pocket [chemical binding]; other site 1197719006082 colanic acid biosynthesis protein; Provisional; Region: PRK10017 1197719006083 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1197719006084 colanic acid exporter; Provisional; Region: PRK10459 1197719006085 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1197719006086 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1197719006087 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1197719006088 phosphomannomutase CpsG; Provisional; Region: PRK15414 1197719006089 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1197719006090 active site 1197719006091 substrate binding site [chemical binding]; other site 1197719006092 metal binding site [ion binding]; metal-binding site 1197719006093 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1197719006094 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1197719006095 Substrate binding site; other site 1197719006096 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1197719006097 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1197719006098 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1197719006099 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1197719006100 active site 1197719006101 GDP-Mannose binding site [chemical binding]; other site 1197719006102 dimer interface [polypeptide binding]; other site 1197719006103 modified nudix motif 1197719006104 metal binding site [ion binding]; metal-binding site 1197719006105 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1197719006106 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1197719006107 NADP binding site [chemical binding]; other site 1197719006108 active site 1197719006109 putative substrate binding site [chemical binding]; other site 1197719006110 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1197719006111 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1197719006112 NADP-binding site; other site 1197719006113 homotetramer interface [polypeptide binding]; other site 1197719006114 substrate binding site [chemical binding]; other site 1197719006115 homodimer interface [polypeptide binding]; other site 1197719006116 active site 1197719006117 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1197719006118 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1197719006119 putative trimer interface [polypeptide binding]; other site 1197719006120 putative active site [active] 1197719006121 putative substrate binding site [chemical binding]; other site 1197719006122 putative CoA binding site [chemical binding]; other site 1197719006123 putative glycosyl transferase; Provisional; Region: PRK10063 1197719006124 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1197719006125 metal-binding site 1197719006126 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 1197719006127 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1197719006128 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1197719006129 putative acyl transferase; Provisional; Region: PRK10191 1197719006130 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1197719006131 trimer interface [polypeptide binding]; other site 1197719006132 active site 1197719006133 substrate binding site [chemical binding]; other site 1197719006134 CoA binding site [chemical binding]; other site 1197719006135 putative glycosyl transferase; Provisional; Region: PRK10018 1197719006136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1197719006137 active site 1197719006138 tyrosine kinase; Provisional; Region: PRK11519 1197719006139 Chain length determinant protein; Region: Wzz; pfam02706 1197719006140 Chain length determinant protein; Region: Wzz; cl15801 1197719006141 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1197719006142 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1197719006143 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1197719006144 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1197719006145 active site 1197719006146 polysaccharide export protein Wza; Provisional; Region: PRK15078 1197719006147 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1197719006148 SLBB domain; Region: SLBB; pfam10531 1197719006149 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1197719006150 FOG: CBS domain [General function prediction only]; Region: COG0517 1197719006151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1197719006152 Transporter associated domain; Region: CorC_HlyC; smart01091 1197719006153 putative assembly protein; Provisional; Region: PRK10833 1197719006154 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1197719006155 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1197719006156 trimer interface [polypeptide binding]; other site 1197719006157 active site 1197719006158 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1197719006159 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1197719006160 ATP-binding site [chemical binding]; other site 1197719006161 Sugar specificity; other site 1197719006162 Pyrimidine base specificity; other site 1197719006163 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1197719006164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719006165 heme pocket [chemical binding]; other site 1197719006166 putative active site [active] 1197719006167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719006168 PAS domain; Region: PAS_9; pfam13426 1197719006169 putative active site [active] 1197719006170 heme pocket [chemical binding]; other site 1197719006171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1197719006172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719006173 metal binding site [ion binding]; metal-binding site 1197719006174 active site 1197719006175 I-site; other site 1197719006176 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719006177 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1197719006178 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1197719006179 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1197719006180 minor groove reading motif; other site 1197719006181 helix-hairpin-helix signature motif; other site 1197719006182 substrate binding pocket [chemical binding]; other site 1197719006183 active site 1197719006184 putative chaperone; Provisional; Region: PRK11678 1197719006185 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1197719006186 nucleotide binding site [chemical binding]; other site 1197719006187 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1197719006188 SBD interface [polypeptide binding]; other site 1197719006189 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1197719006190 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719006191 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719006192 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1197719006193 Protein export membrane protein; Region: SecD_SecF; cl14618 1197719006194 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1197719006195 putative transporter; Provisional; Region: PRK10504 1197719006196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006197 putative substrate translocation pore; other site 1197719006198 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1197719006199 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719006200 dimerization interface [polypeptide binding]; other site 1197719006201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719006202 dimer interface [polypeptide binding]; other site 1197719006203 phosphorylation site [posttranslational modification] 1197719006204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719006205 ATP binding site [chemical binding]; other site 1197719006206 Mg2+ binding site [ion binding]; other site 1197719006207 G-X-G motif; other site 1197719006208 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1197719006209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719006210 active site 1197719006211 phosphorylation site [posttranslational modification] 1197719006212 intermolecular recognition site; other site 1197719006213 dimerization interface [polypeptide binding]; other site 1197719006214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719006215 DNA binding site [nucleotide binding] 1197719006216 putative protease; Provisional; Region: PRK15452 1197719006217 Peptidase family U32; Region: Peptidase_U32; pfam01136 1197719006218 lipid kinase; Reviewed; Region: PRK13054 1197719006219 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1197719006220 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1197719006221 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1197719006222 putative active site; other site 1197719006223 catalytic residue [active] 1197719006224 nucleoside transporter; Region: 2A0110; TIGR00889 1197719006225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006226 putative substrate translocation pore; other site 1197719006227 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1197719006228 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719006229 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1197719006230 substrate binding site [chemical binding]; other site 1197719006231 ATP binding site [chemical binding]; other site 1197719006232 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1197719006233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719006234 DNA-binding site [nucleotide binding]; DNA binding site 1197719006235 UTRA domain; Region: UTRA; pfam07702 1197719006236 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1197719006237 dimer interface [polypeptide binding]; other site 1197719006238 substrate binding site [chemical binding]; other site 1197719006239 ATP binding site [chemical binding]; other site 1197719006240 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1197719006241 substrate binding site [chemical binding]; other site 1197719006242 multimerization interface [polypeptide binding]; other site 1197719006243 ATP binding site [chemical binding]; other site 1197719006244 Predicted integral membrane protein [Function unknown]; Region: COG5455 1197719006245 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1197719006246 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1197719006247 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1197719006248 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719006249 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719006250 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719006251 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 1197719006252 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719006253 fimbrial chaperone protein; Provisional; Region: PRK15220 1197719006254 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1197719006255 antiporter inner membrane protein; Provisional; Region: PRK11670 1197719006256 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1197719006257 Walker A motif; other site 1197719006258 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1197719006259 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1197719006260 active site 1197719006261 HIGH motif; other site 1197719006262 KMSKS motif; other site 1197719006263 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1197719006264 tRNA binding surface [nucleotide binding]; other site 1197719006265 anticodon binding site; other site 1197719006266 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1197719006267 dimer interface [polypeptide binding]; other site 1197719006268 putative tRNA-binding site [nucleotide binding]; other site 1197719006269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1197719006270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1197719006271 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1197719006272 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1197719006273 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1197719006274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719006275 active site 1197719006276 phosphorylation site [posttranslational modification] 1197719006277 intermolecular recognition site; other site 1197719006278 dimerization interface [polypeptide binding]; other site 1197719006279 LytTr DNA-binding domain; Region: LytTR; pfam04397 1197719006280 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1197719006281 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1197719006282 GAF domain; Region: GAF; pfam01590 1197719006283 Histidine kinase; Region: His_kinase; pfam06580 1197719006284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719006285 ATP binding site [chemical binding]; other site 1197719006286 Mg2+ binding site [ion binding]; other site 1197719006287 G-X-G motif; other site 1197719006288 transcriptional regulator MirA; Provisional; Region: PRK15043 1197719006289 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1197719006290 DNA binding residues [nucleotide binding] 1197719006291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719006292 putative PBP binding loops; other site 1197719006293 ABC-ATPase subunit interface; other site 1197719006294 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1197719006295 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1197719006296 Walker A/P-loop; other site 1197719006297 ATP binding site [chemical binding]; other site 1197719006298 Q-loop/lid; other site 1197719006299 ABC transporter signature motif; other site 1197719006300 Walker B; other site 1197719006301 D-loop; other site 1197719006302 H-loop/switch region; other site 1197719006303 CBS domain; Region: CBS; pfam00571 1197719006304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719006305 dimer interface [polypeptide binding]; other site 1197719006306 conserved gate region; other site 1197719006307 ABC-ATPase subunit interface; other site 1197719006308 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1197719006309 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1197719006310 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1197719006311 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1197719006312 D-lactate dehydrogenase; Provisional; Region: PRK11183 1197719006313 FAD binding domain; Region: FAD_binding_4; pfam01565 1197719006314 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1197719006315 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1197719006316 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1197719006317 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1197719006318 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1197719006319 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1197719006320 oxidoreductase; Provisional; Region: PRK12743 1197719006321 classical (c) SDRs; Region: SDR_c; cd05233 1197719006322 NAD(P) binding site [chemical binding]; other site 1197719006323 active site 1197719006324 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1197719006325 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1197719006326 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1197719006327 FMN binding site [chemical binding]; other site 1197719006328 active site 1197719006329 catalytic residues [active] 1197719006330 substrate binding site [chemical binding]; other site 1197719006331 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1197719006332 salicylate hydroxylase; Provisional; Region: PRK08163 1197719006333 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1197719006334 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1197719006335 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1197719006336 C-terminal domain interface [polypeptide binding]; other site 1197719006337 GSH binding site (G-site) [chemical binding]; other site 1197719006338 putative dimer interface [polypeptide binding]; other site 1197719006339 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1197719006340 dimer interface [polypeptide binding]; other site 1197719006341 N-terminal domain interface [polypeptide binding]; other site 1197719006342 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1197719006343 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1197719006344 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1197719006345 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1197719006346 Cupin domain; Region: Cupin_2; pfam07883 1197719006347 Cupin domain; Region: Cupin_2; pfam07883 1197719006348 benzoate transport; Region: 2A0115; TIGR00895 1197719006349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006350 putative substrate translocation pore; other site 1197719006351 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1197719006352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719006353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719006354 dimerization interface [polypeptide binding]; other site 1197719006355 hypothetical protein; Provisional; Region: PRK01821 1197719006356 hypothetical protein; Provisional; Region: PRK10711 1197719006357 cytidine deaminase; Provisional; Region: PRK09027 1197719006358 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1197719006359 active site 1197719006360 catalytic motif [active] 1197719006361 Zn binding site [ion binding]; other site 1197719006362 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1197719006363 active site 1197719006364 catalytic motif [active] 1197719006365 Zn binding site [ion binding]; other site 1197719006366 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1197719006367 putative active site [active] 1197719006368 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1197719006369 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1197719006370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719006371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719006372 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1197719006373 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1197719006374 homodimer interface [polypeptide binding]; other site 1197719006375 active site 1197719006376 FMN binding site [chemical binding]; other site 1197719006377 substrate binding site [chemical binding]; other site 1197719006378 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1197719006379 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1197719006380 TM-ABC transporter signature motif; other site 1197719006381 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1197719006382 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1197719006383 Walker A/P-loop; other site 1197719006384 ATP binding site [chemical binding]; other site 1197719006385 Q-loop/lid; other site 1197719006386 ABC transporter signature motif; other site 1197719006387 Walker B; other site 1197719006388 D-loop; other site 1197719006389 H-loop/switch region; other site 1197719006390 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1197719006391 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1197719006392 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1197719006393 ligand binding site [chemical binding]; other site 1197719006394 calcium binding site [ion binding]; other site 1197719006395 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1197719006396 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719006397 DNA binding site [nucleotide binding] 1197719006398 domain linker motif; other site 1197719006399 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1197719006400 dimerization interface (closed form) [polypeptide binding]; other site 1197719006401 ligand binding site [chemical binding]; other site 1197719006402 Predicted membrane protein [Function unknown]; Region: COG2311 1197719006403 hypothetical protein; Provisional; Region: PRK10835 1197719006404 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1197719006405 GTP cyclohydrolase I; Provisional; Region: PLN03044 1197719006406 active site 1197719006407 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1197719006408 S-formylglutathione hydrolase; Region: PLN02442 1197719006409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719006410 sequence-specific DNA binding site [nucleotide binding]; other site 1197719006411 salt bridge; other site 1197719006412 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1197719006413 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1197719006414 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1197719006415 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1197719006416 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1197719006417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719006418 motif II; other site 1197719006419 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1197719006420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006421 putative substrate translocation pore; other site 1197719006422 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1197719006423 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1197719006424 N-terminal plug; other site 1197719006425 ligand-binding site [chemical binding]; other site 1197719006426 lysine transporter; Provisional; Region: PRK10836 1197719006427 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1197719006428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719006429 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1197719006430 putative dimerization interface [polypeptide binding]; other site 1197719006431 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1197719006432 endonuclease IV; Provisional; Region: PRK01060 1197719006433 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1197719006434 AP (apurinic/apyrimidinic) site pocket; other site 1197719006435 DNA interaction; other site 1197719006436 Metal-binding active site; metal-binding site 1197719006437 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1197719006438 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1197719006439 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1197719006440 active site 1197719006441 P-loop; other site 1197719006442 phosphorylation site [posttranslational modification] 1197719006443 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1197719006444 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1197719006445 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1197719006446 putative substrate binding site [chemical binding]; other site 1197719006447 putative ATP binding site [chemical binding]; other site 1197719006448 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1197719006449 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719006450 active site 1197719006451 phosphorylation site [posttranslational modification] 1197719006452 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1197719006453 dimerization domain swap beta strand [polypeptide binding]; other site 1197719006454 regulatory protein interface [polypeptide binding]; other site 1197719006455 active site 1197719006456 regulatory phosphorylation site [posttranslational modification]; other site 1197719006457 sugar efflux transporter B; Provisional; Region: PRK15011 1197719006458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006459 putative substrate translocation pore; other site 1197719006460 Flagellin N-methylase; Region: FliB; cl00497 1197719006461 elongation factor P; Provisional; Region: PRK04542 1197719006462 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1197719006463 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1197719006464 RNA binding site [nucleotide binding]; other site 1197719006465 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1197719006466 RNA binding site [nucleotide binding]; other site 1197719006467 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1197719006468 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1197719006469 molybdopterin cofactor binding site; other site 1197719006470 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719006471 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1197719006472 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719006473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719006474 homodimer interface [polypeptide binding]; other site 1197719006475 catalytic residue [active] 1197719006476 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1197719006477 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1197719006478 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1197719006479 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1197719006480 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1197719006481 active site 1197719006482 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1197719006483 NlpC/P60 family; Region: NLPC_P60; pfam00877 1197719006484 phage resistance protein; Provisional; Region: PRK10551 1197719006485 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1197719006486 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719006487 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1197719006488 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1197719006489 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1197719006490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719006491 dimer interface [polypeptide binding]; other site 1197719006492 conserved gate region; other site 1197719006493 putative PBP binding loops; other site 1197719006494 ABC-ATPase subunit interface; other site 1197719006495 microcin C ABC transporter permease; Provisional; Region: PRK15021 1197719006496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719006497 dimer interface [polypeptide binding]; other site 1197719006498 conserved gate region; other site 1197719006499 ABC-ATPase subunit interface; other site 1197719006500 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1197719006501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719006502 Walker A/P-loop; other site 1197719006503 ATP binding site [chemical binding]; other site 1197719006504 Q-loop/lid; other site 1197719006505 ABC transporter signature motif; other site 1197719006506 Walker B; other site 1197719006507 D-loop; other site 1197719006508 H-loop/switch region; other site 1197719006509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1197719006510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719006511 Walker A/P-loop; other site 1197719006512 ATP binding site [chemical binding]; other site 1197719006513 Q-loop/lid; other site 1197719006514 ABC transporter signature motif; other site 1197719006515 Walker B; other site 1197719006516 D-loop; other site 1197719006517 H-loop/switch region; other site 1197719006518 hypothetical protein; Provisional; Region: PRK11835 1197719006519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006520 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1197719006521 putative substrate translocation pore; other site 1197719006522 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1197719006523 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719006524 RNA binding surface [nucleotide binding]; other site 1197719006525 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1197719006526 active site 1197719006527 uracil binding [chemical binding]; other site 1197719006528 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1197719006529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719006530 ATP binding site [chemical binding]; other site 1197719006531 putative Mg++ binding site [ion binding]; other site 1197719006532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719006533 nucleotide binding region [chemical binding]; other site 1197719006534 ATP-binding site [chemical binding]; other site 1197719006535 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1197719006536 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1197719006537 5S rRNA interface [nucleotide binding]; other site 1197719006538 CTC domain interface [polypeptide binding]; other site 1197719006539 L16 interface [polypeptide binding]; other site 1197719006540 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1197719006541 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1197719006542 hypothetical protein; Provisional; Region: PRK13689 1197719006543 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1197719006544 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1197719006545 Sulfatase; Region: Sulfatase; pfam00884 1197719006546 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1197719006547 transcriptional regulator NarP; Provisional; Region: PRK10403 1197719006548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719006549 active site 1197719006550 phosphorylation site [posttranslational modification] 1197719006551 intermolecular recognition site; other site 1197719006552 dimerization interface [polypeptide binding]; other site 1197719006553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719006554 DNA binding residues [nucleotide binding] 1197719006555 dimerization interface [polypeptide binding]; other site 1197719006556 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1197719006557 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1197719006558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719006559 binding surface 1197719006560 TPR motif; other site 1197719006561 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1197719006562 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1197719006563 catalytic residues [active] 1197719006564 central insert; other site 1197719006565 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1197719006566 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1197719006567 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1197719006568 heme exporter protein CcmC; Region: ccmC; TIGR01191 1197719006569 heme exporter protein CcmB; Region: ccmB; TIGR01190 1197719006570 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1197719006571 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1197719006572 Walker A/P-loop; other site 1197719006573 ATP binding site [chemical binding]; other site 1197719006574 Q-loop/lid; other site 1197719006575 ABC transporter signature motif; other site 1197719006576 Walker B; other site 1197719006577 D-loop; other site 1197719006578 H-loop/switch region; other site 1197719006579 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1197719006580 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1197719006581 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1197719006582 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1197719006583 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1197719006584 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1197719006585 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1197719006586 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1197719006587 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1197719006588 [4Fe-4S] binding site [ion binding]; other site 1197719006589 molybdopterin cofactor binding site; other site 1197719006590 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1197719006591 molybdopterin cofactor binding site; other site 1197719006592 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1197719006593 ferredoxin-type protein; Provisional; Region: PRK10194 1197719006594 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1197719006595 secondary substrate binding site; other site 1197719006596 primary substrate binding site; other site 1197719006597 inhibition loop; other site 1197719006598 dimerization interface [polypeptide binding]; other site 1197719006599 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1197719006600 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1197719006601 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1197719006602 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1197719006603 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1197719006604 Walker A/P-loop; other site 1197719006605 ATP binding site [chemical binding]; other site 1197719006606 Q-loop/lid; other site 1197719006607 ABC transporter signature motif; other site 1197719006608 Walker B; other site 1197719006609 D-loop; other site 1197719006610 H-loop/switch region; other site 1197719006611 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1197719006612 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1197719006613 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1197719006614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719006615 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1197719006616 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1197719006617 DNA binding site [nucleotide binding] 1197719006618 active site 1197719006619 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1197719006620 ApbE family; Region: ApbE; pfam02424 1197719006621 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1197719006622 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1197719006623 trimer interface [polypeptide binding]; other site 1197719006624 eyelet of channel; other site 1197719006625 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1197719006626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719006627 ATP binding site [chemical binding]; other site 1197719006628 G-X-G motif; other site 1197719006629 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1197719006630 putative binding surface; other site 1197719006631 active site 1197719006632 transcriptional regulator RcsB; Provisional; Region: PRK10840 1197719006633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719006634 active site 1197719006635 phosphorylation site [posttranslational modification] 1197719006636 intermolecular recognition site; other site 1197719006637 dimerization interface [polypeptide binding]; other site 1197719006638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719006639 DNA binding residues [nucleotide binding] 1197719006640 dimerization interface [polypeptide binding]; other site 1197719006641 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1197719006642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719006643 dimer interface [polypeptide binding]; other site 1197719006644 phosphorylation site [posttranslational modification] 1197719006645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719006646 ATP binding site [chemical binding]; other site 1197719006647 Mg2+ binding site [ion binding]; other site 1197719006648 G-X-G motif; other site 1197719006649 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1197719006650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719006651 active site 1197719006652 phosphorylation site [posttranslational modification] 1197719006653 intermolecular recognition site; other site 1197719006654 dimerization interface [polypeptide binding]; other site 1197719006655 DNA gyrase subunit A; Validated; Region: PRK05560 1197719006656 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1197719006657 CAP-like domain; other site 1197719006658 active site 1197719006659 primary dimer interface [polypeptide binding]; other site 1197719006660 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1197719006661 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1197719006662 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1197719006663 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1197719006664 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1197719006665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1197719006666 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1197719006667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719006668 S-adenosylmethionine binding site [chemical binding]; other site 1197719006669 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1197719006670 ATP cone domain; Region: ATP-cone; pfam03477 1197719006671 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1197719006672 active site 1197719006673 dimer interface [polypeptide binding]; other site 1197719006674 catalytic residues [active] 1197719006675 effector binding site; other site 1197719006676 R2 peptide binding site; other site 1197719006677 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1197719006678 dimer interface [polypeptide binding]; other site 1197719006679 putative radical transfer pathway; other site 1197719006680 diiron center [ion binding]; other site 1197719006681 tyrosyl radical; other site 1197719006682 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1197719006683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1197719006684 catalytic loop [active] 1197719006685 iron binding site [ion binding]; other site 1197719006686 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1197719006687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006688 putative substrate translocation pore; other site 1197719006689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719006690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719006691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1197719006692 dimerization interface [polypeptide binding]; other site 1197719006693 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1197719006694 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1197719006695 active site 1197719006696 catalytic site [active] 1197719006697 metal binding site [ion binding]; metal-binding site 1197719006698 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1197719006699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006700 putative substrate translocation pore; other site 1197719006701 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1197719006702 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1197719006703 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1197719006704 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1197719006705 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1197719006706 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1197719006707 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1197719006708 Cysteine-rich domain; Region: CCG; pfam02754 1197719006709 Cysteine-rich domain; Region: CCG; pfam02754 1197719006710 hypothetical protein; Provisional; Region: PRK09956 1197719006711 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719006712 hypothetical protein; Provisional; Region: PRK03673 1197719006713 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1197719006714 putative MPT binding site; other site 1197719006715 Competence-damaged protein; Region: CinA; cl00666 1197719006716 YfaZ precursor; Region: YfaZ; pfam07437 1197719006717 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1197719006718 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1197719006719 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1197719006720 catalytic core [active] 1197719006721 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1197719006722 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1197719006723 inhibitor-cofactor binding pocket; inhibition site 1197719006724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719006725 catalytic residue [active] 1197719006726 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1197719006727 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1197719006728 Ligand binding site; other site 1197719006729 Putative Catalytic site; other site 1197719006730 DXD motif; other site 1197719006731 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1197719006732 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1197719006733 active site 1197719006734 substrate binding site [chemical binding]; other site 1197719006735 cosubstrate binding site; other site 1197719006736 catalytic site [active] 1197719006737 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1197719006738 active site 1197719006739 hexamer interface [polypeptide binding]; other site 1197719006740 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1197719006741 NAD binding site [chemical binding]; other site 1197719006742 substrate binding site [chemical binding]; other site 1197719006743 active site 1197719006744 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1197719006745 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1197719006746 putative active site [active] 1197719006747 putative catalytic site [active] 1197719006748 putative Zn binding site [ion binding]; other site 1197719006749 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1197719006750 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1197719006751 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1197719006752 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1197719006753 signal transduction protein PmrD; Provisional; Region: PRK15450 1197719006754 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1197719006755 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1197719006756 acyl-activating enzyme (AAE) consensus motif; other site 1197719006757 putative AMP binding site [chemical binding]; other site 1197719006758 putative active site [active] 1197719006759 putative CoA binding site [chemical binding]; other site 1197719006760 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1197719006761 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1197719006762 active site 1197719006763 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1197719006764 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1197719006765 substrate binding site [chemical binding]; other site 1197719006766 oxyanion hole (OAH) forming residues; other site 1197719006767 trimer interface [polypeptide binding]; other site 1197719006768 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1197719006769 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1197719006770 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1197719006771 dimer interface [polypeptide binding]; other site 1197719006772 tetramer interface [polypeptide binding]; other site 1197719006773 PYR/PP interface [polypeptide binding]; other site 1197719006774 TPP binding site [chemical binding]; other site 1197719006775 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1197719006776 TPP-binding site; other site 1197719006777 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1197719006778 isochorismate synthases; Region: isochor_syn; TIGR00543 1197719006779 hypothetical protein; Provisional; Region: PRK10404 1197719006780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719006781 Coenzyme A binding pocket [chemical binding]; other site 1197719006782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1197719006783 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1197719006784 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1197719006785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719006786 active site 1197719006787 phosphorylation site [posttranslational modification] 1197719006788 intermolecular recognition site; other site 1197719006789 dimerization interface [polypeptide binding]; other site 1197719006790 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1197719006791 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1197719006792 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1197719006793 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1197719006794 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1197719006795 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1197719006796 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1197719006797 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1197719006798 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1197719006799 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1197719006800 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1197719006801 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719006802 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719006803 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1197719006804 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1197719006805 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1197719006806 catalytic loop [active] 1197719006807 iron binding site [ion binding]; other site 1197719006808 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1197719006809 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1197719006810 [4Fe-4S] binding site [ion binding]; other site 1197719006811 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1197719006812 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1197719006813 SLBB domain; Region: SLBB; pfam10531 1197719006814 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1197719006815 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1197719006816 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1197719006817 putative dimer interface [polypeptide binding]; other site 1197719006818 [2Fe-2S] cluster binding site [ion binding]; other site 1197719006819 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1197719006820 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1197719006821 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1197719006822 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1197719006823 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1197719006824 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1197719006825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719006826 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1197719006827 putative dimerization interface [polypeptide binding]; other site 1197719006828 aminotransferase AlaT; Validated; Region: PRK09265 1197719006829 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719006830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719006831 homodimer interface [polypeptide binding]; other site 1197719006832 catalytic residue [active] 1197719006833 5'-nucleotidase; Provisional; Region: PRK03826 1197719006834 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1197719006835 transmembrane helices; other site 1197719006836 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719006837 TrkA-C domain; Region: TrkA_C; pfam02080 1197719006838 TrkA-C domain; Region: TrkA_C; pfam02080 1197719006839 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1197719006840 putative phosphatase; Provisional; Region: PRK11587 1197719006841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719006842 motif II; other site 1197719006843 hypothetical protein; Validated; Region: PRK05445 1197719006844 hypothetical protein; Provisional; Region: PRK01816 1197719006845 propionate/acetate kinase; Provisional; Region: PRK12379 1197719006846 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1197719006847 phosphate acetyltransferase; Reviewed; Region: PRK05632 1197719006848 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1197719006849 DRTGG domain; Region: DRTGG; pfam07085 1197719006850 phosphate acetyltransferase; Region: pta; TIGR00651 1197719006851 hypothetical protein; Provisional; Region: PRK11588 1197719006852 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1197719006853 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1197719006854 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1197719006855 PYR/PP interface [polypeptide binding]; other site 1197719006856 dimer interface [polypeptide binding]; other site 1197719006857 TPP binding site [chemical binding]; other site 1197719006858 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1197719006859 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1197719006860 TPP-binding site [chemical binding]; other site 1197719006861 dimer interface [polypeptide binding]; other site 1197719006862 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1197719006863 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1197719006864 active site 1197719006865 P-loop; other site 1197719006866 phosphorylation site [posttranslational modification] 1197719006867 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719006868 active site 1197719006869 phosphorylation site [posttranslational modification] 1197719006870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1197719006871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719006872 DNA binding site [nucleotide binding] 1197719006873 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1197719006874 putative dimerization interface [polypeptide binding]; other site 1197719006875 putative ligand binding site [chemical binding]; other site 1197719006876 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1197719006877 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1197719006878 nudix motif; other site 1197719006879 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1197719006880 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1197719006881 active site 1197719006882 metal binding site [ion binding]; metal-binding site 1197719006883 homotetramer interface [polypeptide binding]; other site 1197719006884 glutathione S-transferase; Provisional; Region: PRK15113 1197719006885 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1197719006886 C-terminal domain interface [polypeptide binding]; other site 1197719006887 GSH binding site (G-site) [chemical binding]; other site 1197719006888 dimer interface [polypeptide binding]; other site 1197719006889 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1197719006890 N-terminal domain interface [polypeptide binding]; other site 1197719006891 putative dimer interface [polypeptide binding]; other site 1197719006892 putative substrate binding pocket (H-site) [chemical binding]; other site 1197719006893 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1197719006894 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1197719006895 C-terminal domain interface [polypeptide binding]; other site 1197719006896 GSH binding site (G-site) [chemical binding]; other site 1197719006897 dimer interface [polypeptide binding]; other site 1197719006898 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1197719006899 N-terminal domain interface [polypeptide binding]; other site 1197719006900 putative dimer interface [polypeptide binding]; other site 1197719006901 active site 1197719006902 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1197719006903 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1197719006904 putative NAD(P) binding site [chemical binding]; other site 1197719006905 putative active site [active] 1197719006906 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1197719006907 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1197719006908 Walker A/P-loop; other site 1197719006909 ATP binding site [chemical binding]; other site 1197719006910 Q-loop/lid; other site 1197719006911 ABC transporter signature motif; other site 1197719006912 Walker B; other site 1197719006913 D-loop; other site 1197719006914 H-loop/switch region; other site 1197719006915 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719006916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719006917 dimer interface [polypeptide binding]; other site 1197719006918 conserved gate region; other site 1197719006919 putative PBP binding loops; other site 1197719006920 ABC-ATPase subunit interface; other site 1197719006921 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1197719006922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719006923 dimer interface [polypeptide binding]; other site 1197719006924 conserved gate region; other site 1197719006925 putative PBP binding loops; other site 1197719006926 ABC-ATPase subunit interface; other site 1197719006927 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1197719006928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719006929 substrate binding pocket [chemical binding]; other site 1197719006930 membrane-bound complex binding site; other site 1197719006931 hinge residues; other site 1197719006932 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1197719006933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719006934 substrate binding pocket [chemical binding]; other site 1197719006935 membrane-bound complex binding site; other site 1197719006936 hinge residues; other site 1197719006937 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1197719006938 Flavoprotein; Region: Flavoprotein; pfam02441 1197719006939 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1197719006940 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1197719006941 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1197719006942 active site 1197719006943 tetramer interface [polypeptide binding]; other site 1197719006944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719006945 active site 1197719006946 colicin V production protein; Provisional; Region: PRK10845 1197719006947 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1197719006948 cell division protein DedD; Provisional; Region: PRK11633 1197719006949 Sporulation related domain; Region: SPOR; pfam05036 1197719006950 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1197719006951 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1197719006952 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1197719006953 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1197719006954 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1197719006955 hypothetical protein; Provisional; Region: PRK10847 1197719006956 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1197719006957 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1197719006958 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1197719006959 dimerization interface 3.5A [polypeptide binding]; other site 1197719006960 active site 1197719006961 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1197719006962 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1197719006963 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1197719006964 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1197719006965 ligand binding site [chemical binding]; other site 1197719006966 NAD binding site [chemical binding]; other site 1197719006967 catalytic site [active] 1197719006968 homodimer interface [polypeptide binding]; other site 1197719006969 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1197719006970 putative transporter; Provisional; Region: PRK12382 1197719006971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719006972 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1197719006973 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1197719006974 dimer interface [polypeptide binding]; other site 1197719006975 active site 1197719006976 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1197719006977 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1197719006978 YfcL protein; Region: YfcL; pfam08891 1197719006979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1197719006980 hypothetical protein; Provisional; Region: PRK10621 1197719006981 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1197719006982 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1197719006983 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1197719006984 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1197719006985 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1197719006986 Tetramer interface [polypeptide binding]; other site 1197719006987 active site 1197719006988 FMN-binding site [chemical binding]; other site 1197719006989 HemK family putative methylases; Region: hemK_fam; TIGR00536 1197719006990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719006991 S-adenosylmethionine binding site [chemical binding]; other site 1197719006992 hypothetical protein; Provisional; Region: PRK04946 1197719006993 Smr domain; Region: Smr; pfam01713 1197719006994 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1197719006995 catalytic core [active] 1197719006996 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1197719006997 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1197719006998 substrate binding site [chemical binding]; other site 1197719006999 oxyanion hole (OAH) forming residues; other site 1197719007000 trimer interface [polypeptide binding]; other site 1197719007001 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1197719007002 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1197719007003 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1197719007004 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1197719007005 dimer interface [polypeptide binding]; other site 1197719007006 active site 1197719007007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1197719007008 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1197719007009 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1197719007010 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1197719007011 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719007012 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u2_5s; cd10971 1197719007013 putative active site [active] 1197719007014 putative metal binding site [ion binding]; other site 1197719007015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1197719007016 Coenzyme A binding pocket [chemical binding]; other site 1197719007017 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1197719007018 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1197719007019 Transposase; Region: HTH_Tnp_1; cl17663 1197719007020 HTH-like domain; Region: HTH_21; pfam13276 1197719007021 Fimbrial protein; Region: Fimbrial; pfam00419 1197719007022 Fimbrial protein; Region: Fimbrial; pfam00419 1197719007023 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 1197719007024 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719007025 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719007026 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 1197719007027 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719007028 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719007029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1197719007030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719007031 outer membrane protease; Reviewed; Region: PRK10993 1197719007032 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1197719007033 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1197719007034 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1197719007035 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1197719007036 putative acyl-acceptor binding pocket; other site 1197719007037 aminotransferase; Validated; Region: PRK08175 1197719007038 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719007039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719007040 homodimer interface [polypeptide binding]; other site 1197719007041 catalytic residue [active] 1197719007042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1197719007043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719007044 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1197719007045 dimerization domain swap beta strand [polypeptide binding]; other site 1197719007046 regulatory protein interface [polypeptide binding]; other site 1197719007047 active site 1197719007048 regulatory phosphorylation site [posttranslational modification]; other site 1197719007049 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1197719007050 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1197719007051 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1197719007052 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1197719007053 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719007054 active site 1197719007055 phosphorylation site [posttranslational modification] 1197719007056 exoaminopeptidase; Provisional; Region: PRK09961 1197719007057 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 1197719007058 oligomer interface [polypeptide binding]; other site 1197719007059 active site 1197719007060 metal binding site [ion binding]; metal-binding site 1197719007061 aminopeptidase; Provisional; Region: PRK09795 1197719007062 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1197719007063 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1197719007064 active site 1197719007065 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1197719007066 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1197719007067 active site 1197719007068 P-loop; other site 1197719007069 phosphorylation site [posttranslational modification] 1197719007070 glucokinase; Provisional; Region: glk; PRK00292 1197719007071 glucokinase, proteobacterial type; Region: glk; TIGR00749 1197719007072 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1197719007073 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1197719007074 Cl- selectivity filter; other site 1197719007075 Cl- binding residues [ion binding]; other site 1197719007076 pore gating glutamate residue; other site 1197719007077 dimer interface [polypeptide binding]; other site 1197719007078 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1197719007079 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1197719007080 dimer interface [polypeptide binding]; other site 1197719007081 PYR/PP interface [polypeptide binding]; other site 1197719007082 TPP binding site [chemical binding]; other site 1197719007083 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1197719007084 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1197719007085 TPP-binding site [chemical binding]; other site 1197719007086 dimer interface [polypeptide binding]; other site 1197719007087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719007088 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719007089 active site 1197719007090 catalytic tetrad [active] 1197719007091 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1197719007092 manganese transport protein MntH; Reviewed; Region: PRK00701 1197719007093 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1197719007094 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1197719007095 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1197719007096 Nucleoside recognition; Region: Gate; pfam07670 1197719007097 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1197719007098 MASE1; Region: MASE1; pfam05231 1197719007099 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1197719007100 diguanylate cyclase; Region: GGDEF; smart00267 1197719007101 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719007102 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1197719007103 Winged helix-turn helix; Region: HTH_29; pfam13551 1197719007104 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1197719007105 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1197719007106 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1197719007107 active site 1197719007108 HIGH motif; other site 1197719007109 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1197719007110 active site 1197719007111 KMSKS motif; other site 1197719007112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719007113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719007114 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1197719007115 putative dimerization interface [polypeptide binding]; other site 1197719007116 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1197719007117 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1197719007118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1197719007119 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1197719007120 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1197719007121 nucleotide binding pocket [chemical binding]; other site 1197719007122 K-X-D-G motif; other site 1197719007123 catalytic site [active] 1197719007124 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1197719007125 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1197719007126 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1197719007127 Dimer interface [polypeptide binding]; other site 1197719007128 BRCT sequence motif; other site 1197719007129 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1197719007130 cell division protein ZipA; Provisional; Region: PRK03427 1197719007131 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1197719007132 FtsZ protein binding site [polypeptide binding]; other site 1197719007133 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1197719007134 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1197719007135 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1197719007136 dimer interface [polypeptide binding]; other site 1197719007137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719007138 catalytic residue [active] 1197719007139 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1197719007140 dimerization domain swap beta strand [polypeptide binding]; other site 1197719007141 regulatory protein interface [polypeptide binding]; other site 1197719007142 active site 1197719007143 regulatory phosphorylation site [posttranslational modification]; other site 1197719007144 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1197719007145 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1197719007146 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1197719007147 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1197719007148 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1197719007149 HPr interaction site; other site 1197719007150 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1197719007151 active site 1197719007152 phosphorylation site [posttranslational modification] 1197719007153 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1197719007154 dimer interface [polypeptide binding]; other site 1197719007155 pyridoxamine kinase; Validated; Region: PRK05756 1197719007156 pyridoxal binding site [chemical binding]; other site 1197719007157 ATP binding site [chemical binding]; other site 1197719007158 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1197719007159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719007160 DNA-binding site [nucleotide binding]; DNA binding site 1197719007161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719007162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719007163 homodimer interface [polypeptide binding]; other site 1197719007164 catalytic residue [active] 1197719007165 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1197719007166 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1197719007167 catalytic triad [active] 1197719007168 cysteine synthase B; Region: cysM; TIGR01138 1197719007169 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1197719007170 dimer interface [polypeptide binding]; other site 1197719007171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719007172 catalytic residue [active] 1197719007173 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1197719007174 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1197719007175 Walker A/P-loop; other site 1197719007176 ATP binding site [chemical binding]; other site 1197719007177 Q-loop/lid; other site 1197719007178 ABC transporter signature motif; other site 1197719007179 Walker B; other site 1197719007180 D-loop; other site 1197719007181 H-loop/switch region; other site 1197719007182 TOBE-like domain; Region: TOBE_3; pfam12857 1197719007183 sulfate transport protein; Provisional; Region: cysT; CHL00187 1197719007184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719007185 dimer interface [polypeptide binding]; other site 1197719007186 conserved gate region; other site 1197719007187 putative PBP binding loops; other site 1197719007188 ABC-ATPase subunit interface; other site 1197719007189 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1197719007190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719007191 dimer interface [polypeptide binding]; other site 1197719007192 conserved gate region; other site 1197719007193 putative PBP binding loops; other site 1197719007194 ABC-ATPase subunit interface; other site 1197719007195 thiosulfate transporter subunit; Provisional; Region: PRK10852 1197719007196 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1197719007197 short chain dehydrogenase; Provisional; Region: PRK08226 1197719007198 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1197719007199 NAD binding site [chemical binding]; other site 1197719007200 homotetramer interface [polypeptide binding]; other site 1197719007201 homodimer interface [polypeptide binding]; other site 1197719007202 active site 1197719007203 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1197719007204 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1197719007205 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1197719007206 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1197719007207 putative acetyltransferase; Provisional; Region: PRK03624 1197719007208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719007209 Coenzyme A binding pocket [chemical binding]; other site 1197719007210 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1197719007211 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1197719007212 active site 1197719007213 metal binding site [ion binding]; metal-binding site 1197719007214 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1197719007215 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1197719007216 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1197719007217 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1197719007218 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1197719007219 putative NAD(P) binding site [chemical binding]; other site 1197719007220 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1197719007221 transaldolase-like protein; Provisional; Region: PTZ00411 1197719007222 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1197719007223 active site 1197719007224 dimer interface [polypeptide binding]; other site 1197719007225 catalytic residue [active] 1197719007226 transketolase; Reviewed; Region: PRK12753 1197719007227 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1197719007228 TPP-binding site [chemical binding]; other site 1197719007229 dimer interface [polypeptide binding]; other site 1197719007230 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1197719007231 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1197719007232 PYR/PP interface [polypeptide binding]; other site 1197719007233 dimer interface [polypeptide binding]; other site 1197719007234 TPP binding site [chemical binding]; other site 1197719007235 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1197719007236 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1197719007237 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1197719007238 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1197719007239 dimer interface [polypeptide binding]; other site 1197719007240 ADP-ribose binding site [chemical binding]; other site 1197719007241 active site 1197719007242 nudix motif; other site 1197719007243 metal binding site [ion binding]; metal-binding site 1197719007244 putative periplasmic esterase; Provisional; Region: PRK03642 1197719007245 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1197719007246 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1197719007247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1197719007248 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719007249 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1197719007250 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1197719007251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719007252 dimerization interface [polypeptide binding]; other site 1197719007253 Histidine kinase; Region: HisKA_3; pfam07730 1197719007254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719007255 ATP binding site [chemical binding]; other site 1197719007256 Mg2+ binding site [ion binding]; other site 1197719007257 G-X-G motif; other site 1197719007258 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1197719007259 Protein export membrane protein; Region: SecD_SecF; cl14618 1197719007260 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1197719007261 ArsC family; Region: ArsC; pfam03960 1197719007262 putative catalytic residues [active] 1197719007263 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1197719007264 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1197719007265 metal binding site [ion binding]; metal-binding site 1197719007266 dimer interface [polypeptide binding]; other site 1197719007267 hypothetical protein; Provisional; Region: PRK13664 1197719007268 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1197719007269 Helicase; Region: Helicase_RecD; pfam05127 1197719007270 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1197719007271 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1197719007272 Predicted metalloprotease [General function prediction only]; Region: COG2321 1197719007273 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1197719007274 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1197719007275 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1197719007276 ATP binding site [chemical binding]; other site 1197719007277 active site 1197719007278 substrate binding site [chemical binding]; other site 1197719007279 lipoprotein; Provisional; Region: PRK11679 1197719007280 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1197719007281 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1197719007282 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1197719007283 dimer interface [polypeptide binding]; other site 1197719007284 active site 1197719007285 catalytic residue [active] 1197719007286 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1197719007287 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1197719007288 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1197719007289 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1197719007290 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1197719007291 catalytic triad [active] 1197719007292 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1197719007293 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1197719007294 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1197719007295 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1197719007296 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1197719007297 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1197719007298 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1197719007299 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1197719007300 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1197719007301 Peptidase family M48; Region: Peptidase_M48; cl12018 1197719007302 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1197719007303 ArsC family; Region: ArsC; pfam03960 1197719007304 catalytic residues [active] 1197719007305 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1197719007306 DNA replication initiation factor; Provisional; Region: PRK08084 1197719007307 uracil transporter; Provisional; Region: PRK10720 1197719007308 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719007309 active site 1197719007310 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1197719007311 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1197719007312 dimerization interface [polypeptide binding]; other site 1197719007313 putative ATP binding site [chemical binding]; other site 1197719007314 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1197719007315 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1197719007316 active site 1197719007317 substrate binding site [chemical binding]; other site 1197719007318 cosubstrate binding site; other site 1197719007319 catalytic site [active] 1197719007320 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1197719007321 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1197719007322 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1197719007323 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1197719007324 putative active site [active] 1197719007325 catalytic site [active] 1197719007326 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1197719007327 domain interface [polypeptide binding]; other site 1197719007328 active site 1197719007329 catalytic site [active] 1197719007330 exopolyphosphatase; Provisional; Region: PRK10854 1197719007331 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1197719007332 MASE1; Region: MASE1; pfam05231 1197719007333 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1197719007334 diguanylate cyclase; Region: GGDEF; smart00267 1197719007335 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719007336 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1197719007337 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1197719007338 GMP synthase; Reviewed; Region: guaA; PRK00074 1197719007339 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1197719007340 AMP/PPi binding site [chemical binding]; other site 1197719007341 candidate oxyanion hole; other site 1197719007342 catalytic triad [active] 1197719007343 potential glutamine specificity residues [chemical binding]; other site 1197719007344 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1197719007345 ATP Binding subdomain [chemical binding]; other site 1197719007346 Ligand Binding sites [chemical binding]; other site 1197719007347 Dimerization subdomain; other site 1197719007348 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1197719007349 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1197719007350 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1197719007351 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1197719007352 active site 1197719007353 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1197719007354 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1197719007355 generic binding surface II; other site 1197719007356 generic binding surface I; other site 1197719007357 outer membrane protein RatA; Provisional; Region: PRK15315 1197719007358 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1197719007359 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1197719007360 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1197719007361 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1197719007362 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1197719007363 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1197719007364 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1197719007365 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1197719007366 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1197719007367 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1197719007368 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1197719007369 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1197719007370 intimin-like protein SinH; Provisional; Region: PRK15318 1197719007371 intimin-like protein SinH; Provisional; Region: PRK15318 1197719007372 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1197719007373 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1197719007374 GTP-binding protein Der; Reviewed; Region: PRK00093 1197719007375 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1197719007376 G1 box; other site 1197719007377 GTP/Mg2+ binding site [chemical binding]; other site 1197719007378 Switch I region; other site 1197719007379 G2 box; other site 1197719007380 Switch II region; other site 1197719007381 G3 box; other site 1197719007382 G4 box; other site 1197719007383 G5 box; other site 1197719007384 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1197719007385 G1 box; other site 1197719007386 GTP/Mg2+ binding site [chemical binding]; other site 1197719007387 Switch I region; other site 1197719007388 G2 box; other site 1197719007389 G3 box; other site 1197719007390 Switch II region; other site 1197719007391 G4 box; other site 1197719007392 G5 box; other site 1197719007393 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1197719007394 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1197719007395 Trp docking motif [polypeptide binding]; other site 1197719007396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1197719007397 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1197719007398 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1197719007399 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1197719007400 dimer interface [polypeptide binding]; other site 1197719007401 motif 1; other site 1197719007402 active site 1197719007403 motif 2; other site 1197719007404 motif 3; other site 1197719007405 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1197719007406 anticodon binding site; other site 1197719007407 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1197719007408 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1197719007409 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1197719007410 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1197719007411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719007412 non-specific DNA binding site [nucleotide binding]; other site 1197719007413 salt bridge; other site 1197719007414 sequence-specific DNA binding site [nucleotide binding]; other site 1197719007415 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1197719007416 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1197719007417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719007418 FeS/SAM binding site; other site 1197719007419 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1197719007420 active site 1197719007421 multimer interface [polypeptide binding]; other site 1197719007422 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719007423 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1197719007424 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1197719007425 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1197719007426 4Fe-4S binding domain; Region: Fer4; pfam00037 1197719007427 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1197719007428 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1197719007429 putative [Fe4-S4] binding site [ion binding]; other site 1197719007430 putative molybdopterin cofactor binding site [chemical binding]; other site 1197719007431 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1197719007432 putative molybdopterin cofactor binding site; other site 1197719007433 penicillin-binding protein 1C; Provisional; Region: PRK11240 1197719007434 Transglycosylase; Region: Transgly; pfam00912 1197719007435 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1197719007436 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1197719007437 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1197719007438 MG2 domain; Region: A2M_N; pfam01835 1197719007439 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1197719007440 surface patch; other site 1197719007441 thioester region; other site 1197719007442 specificity defining residues; other site 1197719007443 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1197719007444 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1197719007445 active site residue [active] 1197719007446 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1197719007447 active site residue [active] 1197719007448 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1197719007449 aminopeptidase B; Provisional; Region: PRK05015 1197719007450 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1197719007451 interface (dimer of trimers) [polypeptide binding]; other site 1197719007452 Substrate-binding/catalytic site; other site 1197719007453 Zn-binding sites [ion binding]; other site 1197719007454 hypothetical protein; Provisional; Region: PRK10721 1197719007455 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1197719007456 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1197719007457 catalytic loop [active] 1197719007458 iron binding site [ion binding]; other site 1197719007459 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1197719007460 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1197719007461 nucleotide binding site [chemical binding]; other site 1197719007462 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1197719007463 SBD interface [polypeptide binding]; other site 1197719007464 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1197719007465 DnaJ domain; Region: DnaJ; pfam00226 1197719007466 HSP70 interaction site [polypeptide binding]; other site 1197719007467 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1197719007468 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1197719007469 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1197719007470 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1197719007471 trimerization site [polypeptide binding]; other site 1197719007472 active site 1197719007473 cysteine desulfurase; Provisional; Region: PRK14012 1197719007474 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1197719007475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1197719007476 catalytic residue [active] 1197719007477 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1197719007478 Rrf2 family protein; Region: rrf2_super; TIGR00738 1197719007479 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1197719007480 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1197719007481 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1197719007482 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1197719007483 active site 1197719007484 dimerization interface [polypeptide binding]; other site 1197719007485 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 1197719007486 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1197719007487 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1197719007488 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1197719007489 FAD binding pocket [chemical binding]; other site 1197719007490 FAD binding motif [chemical binding]; other site 1197719007491 phosphate binding motif [ion binding]; other site 1197719007492 beta-alpha-beta structure motif; other site 1197719007493 NAD binding pocket [chemical binding]; other site 1197719007494 Iron coordination center [ion binding]; other site 1197719007495 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 1197719007496 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1197719007497 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1197719007498 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1197719007499 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1197719007500 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1197719007501 PRD domain; Region: PRD; pfam00874 1197719007502 PRD domain; Region: PRD; pfam00874 1197719007503 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1197719007504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719007505 putative substrate translocation pore; other site 1197719007506 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1197719007507 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1197719007508 dimer interface [polypeptide binding]; other site 1197719007509 active site 1197719007510 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1197719007511 folate binding site [chemical binding]; other site 1197719007512 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1197719007513 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1197719007514 heme-binding site [chemical binding]; other site 1197719007515 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1197719007516 FAD binding pocket [chemical binding]; other site 1197719007517 FAD binding motif [chemical binding]; other site 1197719007518 phosphate binding motif [ion binding]; other site 1197719007519 beta-alpha-beta structure motif; other site 1197719007520 NAD binding pocket [chemical binding]; other site 1197719007521 Heme binding pocket [chemical binding]; other site 1197719007522 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1197719007523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719007524 DNA binding site [nucleotide binding] 1197719007525 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1197719007526 lysine decarboxylase CadA; Provisional; Region: PRK15400 1197719007527 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1197719007528 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1197719007529 homodimer interface [polypeptide binding]; other site 1197719007530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719007531 catalytic residue [active] 1197719007532 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1197719007533 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1197719007534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719007535 putative substrate translocation pore; other site 1197719007536 POT family; Region: PTR2; pfam00854 1197719007537 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1197719007538 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1197719007539 response regulator GlrR; Provisional; Region: PRK15115 1197719007540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719007541 active site 1197719007542 phosphorylation site [posttranslational modification] 1197719007543 intermolecular recognition site; other site 1197719007544 dimerization interface [polypeptide binding]; other site 1197719007545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719007546 Walker A motif; other site 1197719007547 ATP binding site [chemical binding]; other site 1197719007548 Walker B motif; other site 1197719007549 arginine finger; other site 1197719007550 hypothetical protein; Provisional; Region: PRK10722 1197719007551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1197719007552 HAMP domain; Region: HAMP; pfam00672 1197719007553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719007554 dimer interface [polypeptide binding]; other site 1197719007555 phosphorylation site [posttranslational modification] 1197719007556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719007557 ATP binding site [chemical binding]; other site 1197719007558 Mg2+ binding site [ion binding]; other site 1197719007559 G-X-G motif; other site 1197719007560 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1197719007561 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1197719007562 dimerization interface [polypeptide binding]; other site 1197719007563 ATP binding site [chemical binding]; other site 1197719007564 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 1197719007565 dimerization interface [polypeptide binding]; other site 1197719007566 ATP binding site [chemical binding]; other site 1197719007567 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1197719007568 putative active site [active] 1197719007569 catalytic triad [active] 1197719007570 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1197719007571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719007572 substrate binding pocket [chemical binding]; other site 1197719007573 membrane-bound complex binding site; other site 1197719007574 hinge residues; other site 1197719007575 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719007576 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719007577 catalytic residue [active] 1197719007578 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1197719007579 nucleoside/Zn binding site; other site 1197719007580 dimer interface [polypeptide binding]; other site 1197719007581 catalytic motif [active] 1197719007582 hypothetical protein; Provisional; Region: PRK11590 1197719007583 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1197719007584 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1197719007585 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1197719007586 active site turn [active] 1197719007587 phosphorylation site [posttranslational modification] 1197719007588 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1197719007589 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1197719007590 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1197719007591 putative active site [active] 1197719007592 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1197719007593 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1197719007594 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1197719007595 putative active site [active] 1197719007596 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1197719007597 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1197719007598 active site 1197719007599 hydrophilic channel; other site 1197719007600 dimerization interface [polypeptide binding]; other site 1197719007601 catalytic residues [active] 1197719007602 active site lid [active] 1197719007603 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1197719007604 Recombination protein O N terminal; Region: RecO_N; pfam11967 1197719007605 Recombination protein O C terminal; Region: RecO_C; pfam02565 1197719007606 GTPase Era; Reviewed; Region: era; PRK00089 1197719007607 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1197719007608 G1 box; other site 1197719007609 GTP/Mg2+ binding site [chemical binding]; other site 1197719007610 Switch I region; other site 1197719007611 G2 box; other site 1197719007612 Switch II region; other site 1197719007613 G3 box; other site 1197719007614 G4 box; other site 1197719007615 G5 box; other site 1197719007616 KH domain; Region: KH_2; pfam07650 1197719007617 ribonuclease III; Reviewed; Region: rnc; PRK00102 1197719007618 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1197719007619 dimerization interface [polypeptide binding]; other site 1197719007620 active site 1197719007621 metal binding site [ion binding]; metal-binding site 1197719007622 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1197719007623 dsRNA binding site [nucleotide binding]; other site 1197719007624 signal peptidase I; Provisional; Region: PRK10861 1197719007625 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1197719007626 Catalytic site [active] 1197719007627 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1197719007628 GTP-binding protein LepA; Provisional; Region: PRK05433 1197719007629 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1197719007630 G1 box; other site 1197719007631 putative GEF interaction site [polypeptide binding]; other site 1197719007632 GTP/Mg2+ binding site [chemical binding]; other site 1197719007633 Switch I region; other site 1197719007634 G2 box; other site 1197719007635 G3 box; other site 1197719007636 Switch II region; other site 1197719007637 G4 box; other site 1197719007638 G5 box; other site 1197719007639 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1197719007640 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1197719007641 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1197719007642 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1197719007643 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1197719007644 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1197719007645 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1197719007646 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1197719007647 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1197719007648 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1197719007649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1197719007650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1197719007651 DNA binding residues [nucleotide binding] 1197719007652 L-aspartate oxidase; Provisional; Region: PRK09077 1197719007653 L-aspartate oxidase; Provisional; Region: PRK06175 1197719007654 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1197719007655 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1197719007656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719007657 S-adenosylmethionine binding site [chemical binding]; other site 1197719007658 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1197719007659 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1197719007660 ATP binding site [chemical binding]; other site 1197719007661 Mg++ binding site [ion binding]; other site 1197719007662 motif III; other site 1197719007663 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719007664 nucleotide binding region [chemical binding]; other site 1197719007665 ATP-binding site [chemical binding]; other site 1197719007666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719007667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719007668 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1197719007669 dimerization interface [polypeptide binding]; other site 1197719007670 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1197719007671 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1197719007672 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1197719007673 ligand binding site [chemical binding]; other site 1197719007674 active site 1197719007675 UGI interface [polypeptide binding]; other site 1197719007676 catalytic site [active] 1197719007677 putative methyltransferase; Provisional; Region: PRK10864 1197719007678 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1197719007679 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1197719007680 thioredoxin 2; Provisional; Region: PRK10996 1197719007681 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1197719007682 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1197719007683 catalytic residues [active] 1197719007684 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1197719007685 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1197719007686 CoA binding domain; Region: CoA_binding_2; pfam13380 1197719007687 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1197719007688 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1197719007689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1197719007690 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1197719007691 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1197719007692 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1197719007693 domain interface [polypeptide binding]; other site 1197719007694 putative active site [active] 1197719007695 catalytic site [active] 1197719007696 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1197719007697 domain interface [polypeptide binding]; other site 1197719007698 putative active site [active] 1197719007699 catalytic site [active] 1197719007700 lipoprotein; Provisional; Region: PRK10759 1197719007701 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1197719007702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719007703 putative substrate translocation pore; other site 1197719007704 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1197719007705 protein disaggregation chaperone; Provisional; Region: PRK10865 1197719007706 Clp amino terminal domain; Region: Clp_N; pfam02861 1197719007707 Clp amino terminal domain; Region: Clp_N; pfam02861 1197719007708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719007709 Walker A motif; other site 1197719007710 ATP binding site [chemical binding]; other site 1197719007711 Walker B motif; other site 1197719007712 arginine finger; other site 1197719007713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719007714 Walker A motif; other site 1197719007715 ATP binding site [chemical binding]; other site 1197719007716 Walker B motif; other site 1197719007717 arginine finger; other site 1197719007718 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1197719007719 hypothetical protein; Provisional; Region: PRK10723 1197719007720 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1197719007721 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1197719007722 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719007723 RNA binding surface [nucleotide binding]; other site 1197719007724 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1197719007725 active site 1197719007726 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1197719007727 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1197719007728 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1197719007729 30S subunit binding site; other site 1197719007730 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1197719007731 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1197719007732 Prephenate dehydratase; Region: PDT; pfam00800 1197719007733 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1197719007734 putative L-Phe binding site [chemical binding]; other site 1197719007735 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1197719007736 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1197719007737 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 1197719007738 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1197719007739 prephenate dehydrogenase; Validated; Region: PRK08507 1197719007740 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1197719007741 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1197719007742 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1197719007743 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1197719007744 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1197719007745 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719007746 metal binding site [ion binding]; metal-binding site 1197719007747 active site 1197719007748 I-site; other site 1197719007749 integrase; Provisional; Region: int; PHA02601 1197719007750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719007751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719007752 active site 1197719007753 DNA binding site [nucleotide binding] 1197719007754 Int/Topo IB signature motif; other site 1197719007755 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1197719007756 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1197719007757 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1197719007758 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 1197719007759 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1197719007760 DksA-like zinc finger domain containing protein; Region: PHA00080 1197719007761 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1197719007762 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1197719007763 active site 1197719007764 catalytic site [active] 1197719007765 substrate binding site [chemical binding]; other site 1197719007766 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1197719007767 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1197719007768 cofactor binding site; other site 1197719007769 DNA binding site [nucleotide binding] 1197719007770 substrate interaction site [chemical binding]; other site 1197719007771 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1197719007772 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1197719007773 DinI-like family; Region: DinI; pfam06183 1197719007774 portal vertex protein; Provisional; Region: Q; PHA02536 1197719007775 Phage portal protein; Region: Phage_portal; pfam04860 1197719007776 terminase ATPase subunit; Provisional; Region: P; PHA02535 1197719007777 terminase ATPase subunit; Provisional; Region: P; PHA02535 1197719007778 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1197719007779 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1197719007780 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 1197719007781 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1197719007782 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1197719007783 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1197719007784 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1197719007785 Phage holin family 2; Region: Phage_holin_2; pfam04550 1197719007786 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1197719007787 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719007788 catalytic residue [active] 1197719007789 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1197719007790 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1197719007791 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1197719007792 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1197719007793 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1197719007794 baseplate wedge subunit; Provisional; Region: W; PHA02516 1197719007795 baseplate assembly protein; Provisional; Region: J; PHA02568 1197719007796 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 1197719007797 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1197719007798 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1197719007799 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1197719007800 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1197719007801 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719007802 major tail sheath protein; Provisional; Region: FI; PHA02560 1197719007803 major tail tube protein; Provisional; Region: FII; PHA02600 1197719007804 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1197719007805 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1197719007806 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1197719007807 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1197719007808 tail protein; Provisional; Region: D; PHA02561 1197719007809 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1197719007810 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1197719007811 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1197719007812 RimM N-terminal domain; Region: RimM; pfam01782 1197719007813 PRC-barrel domain; Region: PRC; pfam05239 1197719007814 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1197719007815 signal recognition particle protein; Provisional; Region: PRK10867 1197719007816 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1197719007817 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1197719007818 P loop; other site 1197719007819 GTP binding site [chemical binding]; other site 1197719007820 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1197719007821 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1197719007822 hypothetical protein; Provisional; Region: PRK11573 1197719007823 Domain of unknown function DUF21; Region: DUF21; pfam01595 1197719007824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1197719007825 Transporter associated domain; Region: CorC_HlyC; smart01091 1197719007826 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1197719007827 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1197719007828 dimer interface [polypeptide binding]; other site 1197719007829 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1197719007830 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1197719007831 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1197719007832 recombination and repair protein; Provisional; Region: PRK10869 1197719007833 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1197719007834 Walker A/P-loop; other site 1197719007835 ATP binding site [chemical binding]; other site 1197719007836 Q-loop/lid; other site 1197719007837 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1197719007838 ABC transporter signature motif; other site 1197719007839 Walker B; other site 1197719007840 D-loop; other site 1197719007841 H-loop/switch region; other site 1197719007842 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1197719007843 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1197719007844 hypothetical protein; Validated; Region: PRK01777 1197719007845 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1197719007846 putative coenzyme Q binding site [chemical binding]; other site 1197719007847 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1197719007848 SmpB-tmRNA interface; other site 1197719007849 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007850 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007851 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007852 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007853 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719007854 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007855 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007856 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007857 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007858 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007859 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719007860 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007861 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007862 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719007863 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007864 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719007865 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1197719007866 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1197719007867 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1197719007868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1197719007869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719007870 Walker A/P-loop; other site 1197719007871 ATP binding site [chemical binding]; other site 1197719007872 Q-loop/lid; other site 1197719007873 ABC transporter signature motif; other site 1197719007874 Walker B; other site 1197719007875 D-loop; other site 1197719007876 H-loop/switch region; other site 1197719007877 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1197719007878 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719007879 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1197719007880 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1197719007881 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1197719007882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1197719007883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1197719007884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719007885 dimer interface [polypeptide binding]; other site 1197719007886 phosphorylation site [posttranslational modification] 1197719007887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719007888 ATP binding site [chemical binding]; other site 1197719007889 Mg2+ binding site [ion binding]; other site 1197719007890 G-X-G motif; other site 1197719007891 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1197719007892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719007893 active site 1197719007894 phosphorylation site [posttranslational modification] 1197719007895 intermolecular recognition site; other site 1197719007896 dimerization interface [polypeptide binding]; other site 1197719007897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719007898 DNA binding site [nucleotide binding] 1197719007899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1197719007900 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1197719007901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1197719007902 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1197719007903 substrate binding pocket [chemical binding]; other site 1197719007904 active site 1197719007905 iron coordination sites [ion binding]; other site 1197719007906 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1197719007907 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1197719007908 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1197719007909 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1197719007910 tetramerization interface [polypeptide binding]; other site 1197719007911 NAD(P) binding site [chemical binding]; other site 1197719007912 catalytic residues [active] 1197719007913 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1197719007914 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1197719007915 inhibitor-cofactor binding pocket; inhibition site 1197719007916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719007917 catalytic residue [active] 1197719007918 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1197719007919 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1197719007920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719007921 DNA-binding site [nucleotide binding]; DNA binding site 1197719007922 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1197719007923 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1197719007924 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1197719007925 bacterial OsmY and nodulation domain; Region: BON; smart00749 1197719007926 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719007927 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1197719007928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1197719007929 dimerization interface [polypeptide binding]; other site 1197719007930 putative DNA binding site [nucleotide binding]; other site 1197719007931 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1197719007932 putative Zn2+ binding site [ion binding]; other site 1197719007933 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1197719007934 active site residue [active] 1197719007935 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1197719007936 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1197719007937 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1197719007938 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1197719007939 hypothetical protein; Provisional; Region: PRK10556 1197719007940 hypothetical protein; Provisional; Region: PRK10132 1197719007941 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1197719007942 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1197719007943 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1197719007944 catalytic residues [active] 1197719007945 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1197719007946 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1197719007947 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1197719007948 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1197719007949 active site 1197719007950 dimer interface [polypeptide binding]; other site 1197719007951 catalytic residues [active] 1197719007952 effector binding site; other site 1197719007953 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1197719007954 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1197719007955 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1197719007956 dimer interface [polypeptide binding]; other site 1197719007957 putative radical transfer pathway; other site 1197719007958 diiron center [ion binding]; other site 1197719007959 tyrosyl radical; other site 1197719007960 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1197719007961 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1197719007962 Walker A/P-loop; other site 1197719007963 ATP binding site [chemical binding]; other site 1197719007964 Q-loop/lid; other site 1197719007965 ABC transporter signature motif; other site 1197719007966 Walker B; other site 1197719007967 D-loop; other site 1197719007968 H-loop/switch region; other site 1197719007969 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1197719007970 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1197719007971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719007972 dimer interface [polypeptide binding]; other site 1197719007973 conserved gate region; other site 1197719007974 putative PBP binding loops; other site 1197719007975 ABC-ATPase subunit interface; other site 1197719007976 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1197719007977 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1197719007978 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1197719007979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719007980 transcriptional repressor MprA; Provisional; Region: PRK10870 1197719007981 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1197719007982 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1197719007983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719007984 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719007985 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1197719007986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719007987 putative substrate translocation pore; other site 1197719007988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719007989 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1197719007990 glutamate--cysteine ligase; Provisional; Region: PRK02107 1197719007991 Predicted membrane protein [Function unknown]; Region: COG1238 1197719007992 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1197719007993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719007994 motif II; other site 1197719007995 carbon storage regulator; Provisional; Region: PRK01712 1197719007996 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1197719007997 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1197719007998 motif 1; other site 1197719007999 active site 1197719008000 motif 2; other site 1197719008001 motif 3; other site 1197719008002 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1197719008003 DHHA1 domain; Region: DHHA1; pfam02272 1197719008004 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1197719008005 recombinase A; Provisional; Region: recA; PRK09354 1197719008006 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1197719008007 hexamer interface [polypeptide binding]; other site 1197719008008 Walker A motif; other site 1197719008009 ATP binding site [chemical binding]; other site 1197719008010 Walker B motif; other site 1197719008011 hypothetical protein; Validated; Region: PRK03661 1197719008012 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1197719008013 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719008014 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719008015 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1197719008016 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1197719008017 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1197719008018 Nucleoside recognition; Region: Gate; pfam07670 1197719008019 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1197719008020 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1197719008021 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1197719008022 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1197719008023 putative NAD(P) binding site [chemical binding]; other site 1197719008024 active site 1197719008025 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1197719008026 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1197719008027 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1197719008028 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719008029 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1197719008030 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1197719008031 putative active site [active] 1197719008032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1197719008033 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1197719008034 GAF domain; Region: GAF; pfam01590 1197719008035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719008036 Walker A motif; other site 1197719008037 ATP binding site [chemical binding]; other site 1197719008038 Walker B motif; other site 1197719008039 arginine finger; other site 1197719008040 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1197719008041 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1197719008042 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1197719008043 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1197719008044 iron binding site [ion binding]; other site 1197719008045 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1197719008046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719008047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719008048 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1197719008049 Acylphosphatase; Region: Acylphosphatase; pfam00708 1197719008050 HypF finger; Region: zf-HYPF; pfam07503 1197719008051 HypF finger; Region: zf-HYPF; pfam07503 1197719008052 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1197719008053 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1197719008054 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1197719008055 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1197719008056 nickel binding site [ion binding]; other site 1197719008057 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1197719008058 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1197719008059 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1197719008060 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1197719008061 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1197719008062 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1197719008063 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1197719008064 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1197719008065 NADH dehydrogenase; Region: NADHdh; cl00469 1197719008066 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1197719008067 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1197719008068 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1197719008069 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 1197719008070 4Fe-4S binding domain; Region: Fer4; cl02805 1197719008071 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1197719008072 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1197719008073 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1197719008074 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1197719008075 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1197719008076 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1197719008077 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1197719008078 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1197719008079 dimerization interface [polypeptide binding]; other site 1197719008080 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1197719008081 ATP binding site [chemical binding]; other site 1197719008082 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1197719008083 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1197719008084 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1197719008085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719008086 Walker A motif; other site 1197719008087 ATP binding site [chemical binding]; other site 1197719008088 Walker B motif; other site 1197719008089 arginine finger; other site 1197719008090 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1197719008091 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1197719008092 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1197719008093 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1197719008094 metal binding site [ion binding]; metal-binding site 1197719008095 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1197719008096 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1197719008097 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1197719008098 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719008099 ABC-ATPase subunit interface; other site 1197719008100 dimer interface [polypeptide binding]; other site 1197719008101 putative PBP binding regions; other site 1197719008102 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1197719008103 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719008104 ABC-ATPase subunit interface; other site 1197719008105 dimer interface [polypeptide binding]; other site 1197719008106 putative PBP binding regions; other site 1197719008107 effector protein YopJ; Provisional; Region: PRK15371 1197719008108 transcriptional activator SprB; Provisional; Region: PRK15320 1197719008109 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1197719008110 transcriptional regulator SirC; Provisional; Region: PRK15044 1197719008111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719008112 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 1197719008113 invasion protein OrgB; Provisional; Region: PRK15322 1197719008114 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 1197719008115 invasion protein OrgA; Provisional; Region: PRK15323 1197719008116 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 1197719008117 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1197719008118 Type III secretion needle MxiH like; Region: MxiH; cl09641 1197719008119 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 1197719008120 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1197719008121 transcriptional regulator HilD; Provisional; Region: PRK15185 1197719008122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719008123 invasion protein regulator; Provisional; Region: PRK12370 1197719008124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719008125 DNA binding site [nucleotide binding] 1197719008126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719008127 binding surface 1197719008128 TPR motif; other site 1197719008129 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1197719008130 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719008131 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719008132 catalytic residue [active] 1197719008133 SicP binding; Region: SicP-binding; pfam09119 1197719008134 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 1197719008135 switch II binding region; other site 1197719008136 Rac1 P-loop interaction site [polypeptide binding]; other site 1197719008137 GTP binding residues [chemical binding]; other site 1197719008138 switch I binding region; other site 1197719008139 chaperone protein SicP; Provisional; Region: PRK15329 1197719008140 putative acyl carrier protein IacP; Validated; Region: PRK08172 1197719008141 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 1197719008142 Invasion plasmid antigen IpaD; Region: IpaD; cl05827 1197719008143 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 1197719008144 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1197719008145 chaperone protein SicA; Provisional; Region: PRK15331 1197719008146 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1197719008147 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1197719008148 type III secretion system protein SpaS; Validated; Region: PRK08156 1197719008149 type III secretion system protein SpaR; Provisional; Region: PRK15332 1197719008150 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1197719008151 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1197719008152 type III secretion system protein SpaO; Validated; Region: PRK08158 1197719008153 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1197719008154 antigen presentation protein SpaN; Provisional; Region: PRK15334 1197719008155 Surface presentation of antigens protein; Region: SPAN; pfam02510 1197719008156 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 1197719008157 ATP synthase SpaL; Validated; Region: PRK08149 1197719008158 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1197719008159 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1197719008160 Walker A motif; other site 1197719008161 ATP binding site [chemical binding]; other site 1197719008162 Walker B motif; other site 1197719008163 Invasion protein B family; Region: Invas_SpaK; cl04129 1197719008164 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1197719008165 type III secretion system protein InvA; Provisional; Region: PRK15337 1197719008166 type III secretion system regulator InvE; Provisional; Region: PRK15338 1197719008167 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1197719008168 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1197719008169 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1197719008170 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1197719008171 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1197719008172 transcriptional regulator InvF; Provisional; Region: PRK15340 1197719008173 InvH outer membrane lipoprotein; Region: InvH; pfam04741 1197719008174 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1197719008175 MutS domain I; Region: MutS_I; pfam01624 1197719008176 MutS domain II; Region: MutS_II; pfam05188 1197719008177 MutS domain III; Region: MutS_III; pfam05192 1197719008178 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1197719008179 Walker A/P-loop; other site 1197719008180 ATP binding site [chemical binding]; other site 1197719008181 Q-loop/lid; other site 1197719008182 ABC transporter signature motif; other site 1197719008183 Walker B; other site 1197719008184 D-loop; other site 1197719008185 H-loop/switch region; other site 1197719008186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1197719008187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1197719008189 putative substrate translocation pore; other site 1197719008190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719008191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719008192 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1197719008193 putative effector binding pocket; other site 1197719008194 dimerization interface [polypeptide binding]; other site 1197719008195 GntP family permease; Region: GntP_permease; pfam02447 1197719008196 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1197719008197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1197719008198 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1197719008199 putative NAD(P) binding site [chemical binding]; other site 1197719008200 active site 1197719008201 putative substrate binding site [chemical binding]; other site 1197719008202 hypothetical protein; Provisional; Region: PRK09989 1197719008203 putative aldolase; Validated; Region: PRK08130 1197719008204 intersubunit interface [polypeptide binding]; other site 1197719008205 active site 1197719008206 Zn2+ binding site [ion binding]; other site 1197719008207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1197719008208 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1197719008209 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719008210 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1197719008211 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719008212 MarR family; Region: MarR_2; cl17246 1197719008213 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1197719008214 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1197719008215 Flavoprotein; Region: Flavoprotein; pfam02441 1197719008216 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1197719008217 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1197719008218 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1197719008219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1197719008220 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1197719008221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1197719008222 DNA binding residues [nucleotide binding] 1197719008223 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1197719008224 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719008225 Peptidase family M23; Region: Peptidase_M23; pfam01551 1197719008226 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1197719008227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719008228 S-adenosylmethionine binding site [chemical binding]; other site 1197719008229 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1197719008230 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1197719008231 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1197719008232 Permutation of conserved domain; other site 1197719008233 active site 1197719008234 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1197719008235 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1197719008236 homotrimer interaction site [polypeptide binding]; other site 1197719008237 zinc binding site [ion binding]; other site 1197719008238 CDP-binding sites; other site 1197719008239 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1197719008240 substrate binding site; other site 1197719008241 dimer interface; other site 1197719008242 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1197719008243 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1197719008244 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1197719008245 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1197719008246 ligand-binding site [chemical binding]; other site 1197719008247 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1197719008248 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1197719008249 CysD dimerization site [polypeptide binding]; other site 1197719008250 G1 box; other site 1197719008251 putative GEF interaction site [polypeptide binding]; other site 1197719008252 GTP/Mg2+ binding site [chemical binding]; other site 1197719008253 Switch I region; other site 1197719008254 G2 box; other site 1197719008255 G3 box; other site 1197719008256 Switch II region; other site 1197719008257 G4 box; other site 1197719008258 G5 box; other site 1197719008259 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1197719008260 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1197719008261 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1197719008262 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1197719008263 Active Sites [active] 1197719008264 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1197719008265 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1197719008266 metal binding site [ion binding]; metal-binding site 1197719008267 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1197719008268 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1197719008269 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1197719008270 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1197719008271 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1197719008272 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1197719008273 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1197719008274 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1197719008275 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1197719008276 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1197719008277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1197719008278 Salmonella outer protein D; Region: SopD; cl14701 1197719008279 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1197719008280 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1197719008281 Active Sites [active] 1197719008282 sulfite reductase subunit beta; Provisional; Region: PRK13504 1197719008283 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1197719008284 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1197719008285 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1197719008286 Flavodoxin; Region: Flavodoxin_1; pfam00258 1197719008287 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1197719008288 FAD binding pocket [chemical binding]; other site 1197719008289 FAD binding motif [chemical binding]; other site 1197719008290 catalytic residues [active] 1197719008291 NAD binding pocket [chemical binding]; other site 1197719008292 phosphate binding motif [ion binding]; other site 1197719008293 beta-alpha-beta structure motif; other site 1197719008294 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1197719008295 active site 1197719008296 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1197719008297 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1197719008298 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1197719008299 enolase; Provisional; Region: eno; PRK00077 1197719008300 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1197719008301 dimer interface [polypeptide binding]; other site 1197719008302 metal binding site [ion binding]; metal-binding site 1197719008303 substrate binding pocket [chemical binding]; other site 1197719008304 CTP synthetase; Validated; Region: pyrG; PRK05380 1197719008305 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1197719008306 Catalytic site [active] 1197719008307 active site 1197719008308 UTP binding site [chemical binding]; other site 1197719008309 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1197719008310 active site 1197719008311 putative oxyanion hole; other site 1197719008312 catalytic triad [active] 1197719008313 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1197719008314 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1197719008315 homodimer interface [polypeptide binding]; other site 1197719008316 metal binding site [ion binding]; metal-binding site 1197719008317 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1197719008318 homodimer interface [polypeptide binding]; other site 1197719008319 active site 1197719008320 putative chemical substrate binding site [chemical binding]; other site 1197719008321 metal binding site [ion binding]; metal-binding site 1197719008322 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1197719008323 HD domain; Region: HD_4; pfam13328 1197719008324 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1197719008325 synthetase active site [active] 1197719008326 NTP binding site [chemical binding]; other site 1197719008327 metal binding site [ion binding]; metal-binding site 1197719008328 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1197719008329 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1197719008330 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1197719008331 TRAM domain; Region: TRAM; pfam01938 1197719008332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719008333 S-adenosylmethionine binding site [chemical binding]; other site 1197719008334 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1197719008335 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1197719008336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719008337 dimerization interface [polypeptide binding]; other site 1197719008338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719008339 dimer interface [polypeptide binding]; other site 1197719008340 phosphorylation site [posttranslational modification] 1197719008341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719008342 ATP binding site [chemical binding]; other site 1197719008343 Mg2+ binding site [ion binding]; other site 1197719008344 G-X-G motif; other site 1197719008345 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1197719008346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719008347 active site 1197719008348 phosphorylation site [posttranslational modification] 1197719008349 intermolecular recognition site; other site 1197719008350 dimerization interface [polypeptide binding]; other site 1197719008351 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1197719008352 putative binding surface; other site 1197719008353 active site 1197719008354 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1197719008355 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1197719008356 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1197719008357 active site 1197719008358 tetramer interface [polypeptide binding]; other site 1197719008359 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1197719008360 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1197719008361 active site 1197719008362 tetramer interface [polypeptide binding]; other site 1197719008363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008365 putative substrate translocation pore; other site 1197719008366 flavodoxin; Provisional; Region: PRK08105 1197719008367 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1197719008368 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1197719008369 probable active site [active] 1197719008370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1197719008371 SecY interacting protein Syd; Provisional; Region: PRK04968 1197719008372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1197719008373 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1197719008374 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1197719008375 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1197719008376 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1197719008377 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1197719008378 serine transporter; Region: stp; TIGR00814 1197719008379 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1197719008380 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1197719008381 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1197719008382 flap endonuclease-like protein; Provisional; Region: PRK09482 1197719008383 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1197719008384 active site 1197719008385 metal binding site 1 [ion binding]; metal-binding site 1197719008386 putative 5' ssDNA interaction site; other site 1197719008387 metal binding site 3; metal-binding site 1197719008388 metal binding site 2 [ion binding]; metal-binding site 1197719008389 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1197719008390 putative DNA binding site [nucleotide binding]; other site 1197719008391 putative metal binding site [ion binding]; other site 1197719008392 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1197719008393 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1197719008394 hypothetical protein; Provisional; Region: PRK10873 1197719008395 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1197719008396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719008397 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1197719008398 dimerization interface [polypeptide binding]; other site 1197719008399 substrate binding pocket [chemical binding]; other site 1197719008400 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1197719008401 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1197719008402 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1197719008403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1197719008404 catalytic residue [active] 1197719008405 CsdA-binding activator; Provisional; Region: PRK15019 1197719008406 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1197719008407 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1197719008408 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1197719008409 putative ATP binding site [chemical binding]; other site 1197719008410 putative substrate interface [chemical binding]; other site 1197719008411 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1197719008412 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1197719008413 MltA specific insert domain; Region: MltA; pfam03562 1197719008414 3D domain; Region: 3D; pfam06725 1197719008415 AMIN domain; Region: AMIN; pfam11741 1197719008416 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1197719008417 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1197719008418 active site 1197719008419 metal binding site [ion binding]; metal-binding site 1197719008420 N-acetylglutamate synthase; Validated; Region: PRK05279 1197719008421 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1197719008422 putative feedback inhibition sensing region; other site 1197719008423 putative nucleotide binding site [chemical binding]; other site 1197719008424 putative substrate binding site [chemical binding]; other site 1197719008425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719008426 Coenzyme A binding pocket [chemical binding]; other site 1197719008427 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1197719008428 AAA domain; Region: AAA_30; pfam13604 1197719008429 Family description; Region: UvrD_C_2; pfam13538 1197719008430 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1197719008431 protease3; Provisional; Region: PRK15101 1197719008432 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1197719008433 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1197719008434 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1197719008435 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1197719008436 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1197719008437 hypothetical protein; Provisional; Region: PRK10332 1197719008438 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1197719008439 hypothetical protein; Provisional; Region: PRK11521 1197719008440 hypothetical protein; Provisional; Region: PRK10557 1197719008441 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1197719008442 hypothetical protein; Provisional; Region: PRK10506 1197719008443 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1197719008444 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1197719008445 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1197719008446 dimerization interface [polypeptide binding]; other site 1197719008447 active site 1197719008448 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1197719008449 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1197719008450 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1197719008451 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1197719008452 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1197719008453 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1197719008454 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1197719008455 putative active site [active] 1197719008456 Ap4A binding site [chemical binding]; other site 1197719008457 nudix motif; other site 1197719008458 putative metal binding site [ion binding]; other site 1197719008459 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1197719008460 putative DNA-binding cleft [nucleotide binding]; other site 1197719008461 putative DNA clevage site; other site 1197719008462 molecular lever; other site 1197719008463 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1197719008464 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1197719008465 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719008466 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719008467 active site 1197719008468 catalytic tetrad [active] 1197719008469 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1197719008470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008471 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1197719008472 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1197719008473 putative acyl-acceptor binding pocket; other site 1197719008474 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1197719008475 acyl-activating enzyme (AAE) consensus motif; other site 1197719008476 putative AMP binding site [chemical binding]; other site 1197719008477 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1197719008478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719008479 DNA binding site [nucleotide binding] 1197719008480 domain linker motif; other site 1197719008481 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1197719008482 dimerization interface (closed form) [polypeptide binding]; other site 1197719008483 ligand binding site [chemical binding]; other site 1197719008484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1197719008485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719008486 DNA binding site [nucleotide binding] 1197719008487 domain linker motif; other site 1197719008488 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1197719008489 dimerization interface (closed form) [polypeptide binding]; other site 1197719008490 ligand binding site [chemical binding]; other site 1197719008491 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1197719008492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1197719008493 active site 1197719008494 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1197719008495 substrate binding site [chemical binding]; other site 1197719008496 catalytic residues [active] 1197719008497 dimer interface [polypeptide binding]; other site 1197719008498 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1197719008499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719008500 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 1197719008501 putative dimerization interface [polypeptide binding]; other site 1197719008502 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1197719008503 aspartate racemase; Region: asp_race; TIGR00035 1197719008504 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1197719008505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008506 putative substrate translocation pore; other site 1197719008507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008508 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1197719008509 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1197719008510 NADP binding site [chemical binding]; other site 1197719008511 homodimer interface [polypeptide binding]; other site 1197719008512 active site 1197719008513 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1197719008514 putative acyltransferase; Provisional; Region: PRK05790 1197719008515 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1197719008516 dimer interface [polypeptide binding]; other site 1197719008517 active site 1197719008518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719008519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719008520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1197719008521 dimerization interface [polypeptide binding]; other site 1197719008522 Predicted membrane protein [Function unknown]; Region: COG4125 1197719008523 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1197719008524 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1197719008525 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1197719008526 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1197719008527 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1197719008528 DNA binding site [nucleotide binding] 1197719008529 autotransport protein MisL; Provisional; Region: PRK15313 1197719008530 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1197719008531 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1197719008532 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1197719008533 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719008534 Peptidase family M23; Region: Peptidase_M23; pfam01551 1197719008535 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1197719008536 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1197719008537 active site 1197719008538 metal binding site [ion binding]; metal-binding site 1197719008539 nudix motif; other site 1197719008540 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1197719008541 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1197719008542 dimer interface [polypeptide binding]; other site 1197719008543 putative anticodon binding site; other site 1197719008544 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1197719008545 motif 1; other site 1197719008546 active site 1197719008547 motif 2; other site 1197719008548 motif 3; other site 1197719008549 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1197719008550 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1197719008551 RF-1 domain; Region: RF-1; pfam00472 1197719008552 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1197719008553 DHH family; Region: DHH; pfam01368 1197719008554 DHHA1 domain; Region: DHHA1; pfam02272 1197719008555 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1197719008556 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1197719008557 dimerization domain [polypeptide binding]; other site 1197719008558 dimer interface [polypeptide binding]; other site 1197719008559 catalytic residues [active] 1197719008560 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1197719008561 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1197719008562 active site 1197719008563 Int/Topo IB signature motif; other site 1197719008564 flavodoxin FldB; Provisional; Region: PRK12359 1197719008565 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1197719008566 hypothetical protein; Provisional; Region: PRK10878 1197719008567 putative global regulator; Reviewed; Region: PRK09559 1197719008568 GDYXXLXY protein; Region: GDYXXLXY; cl02066 1197719008569 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1197719008570 hemolysin; Provisional; Region: PRK15087 1197719008571 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1197719008572 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1197719008573 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1197719008574 beta-galactosidase; Region: BGL; TIGR03356 1197719008575 glycine dehydrogenase; Provisional; Region: PRK05367 1197719008576 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1197719008577 tetramer interface [polypeptide binding]; other site 1197719008578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719008579 catalytic residue [active] 1197719008580 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1197719008581 tetramer interface [polypeptide binding]; other site 1197719008582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719008583 catalytic residue [active] 1197719008584 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1197719008585 lipoyl attachment site [posttranslational modification]; other site 1197719008586 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1197719008587 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1197719008588 oxidoreductase; Provisional; Region: PRK08013 1197719008589 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1197719008590 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1197719008591 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1197719008592 proline aminopeptidase P II; Provisional; Region: PRK10879 1197719008593 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1197719008594 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1197719008595 active site 1197719008596 hypothetical protein; Reviewed; Region: PRK01736 1197719008597 Z-ring-associated protein; Provisional; Region: PRK10972 1197719008598 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1197719008599 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1197719008600 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1197719008601 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1197719008602 ligand binding site [chemical binding]; other site 1197719008603 NAD binding site [chemical binding]; other site 1197719008604 tetramer interface [polypeptide binding]; other site 1197719008605 catalytic site [active] 1197719008606 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1197719008607 L-serine binding site [chemical binding]; other site 1197719008608 ACT domain interface; other site 1197719008609 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1197719008610 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1197719008611 active site 1197719008612 dimer interface [polypeptide binding]; other site 1197719008613 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1197719008614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719008615 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1197719008616 putative dimerization interface [polypeptide binding]; other site 1197719008617 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1197719008618 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1197719008619 active site 1197719008620 substrate binding site [chemical binding]; other site 1197719008621 coenzyme B12 binding site [chemical binding]; other site 1197719008622 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1197719008623 B12 binding site [chemical binding]; other site 1197719008624 cobalt ligand [ion binding]; other site 1197719008625 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1197719008626 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1197719008627 Walker A; other site 1197719008628 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1197719008629 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1197719008630 substrate binding site [chemical binding]; other site 1197719008631 oxyanion hole (OAH) forming residues; other site 1197719008632 trimer interface [polypeptide binding]; other site 1197719008633 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1197719008634 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1197719008635 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1197719008636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719008637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719008638 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1197719008639 dimerization interface [polypeptide binding]; other site 1197719008640 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1197719008641 oxidative stress defense protein; Provisional; Region: PRK11087 1197719008642 arginine exporter protein; Provisional; Region: PRK09304 1197719008643 mechanosensitive channel MscS; Provisional; Region: PRK10334 1197719008644 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1197719008645 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1197719008646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719008647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719008648 dimerization interface [polypeptide binding]; other site 1197719008649 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1197719008650 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1197719008651 membrane protein FdrA; Validated; Region: PRK06091 1197719008652 CoA binding domain; Region: CoA_binding; pfam02629 1197719008653 CoA-ligase; Region: Ligase_CoA; pfam00549 1197719008654 D-galactonate transporter; Region: 2A0114; TIGR00893 1197719008655 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1197719008656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008657 putative substrate translocation pore; other site 1197719008658 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1197719008659 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1197719008660 putative substrate binding site [chemical binding]; other site 1197719008661 nucleotide binding site [chemical binding]; other site 1197719008662 nucleotide binding site [chemical binding]; other site 1197719008663 homodimer interface [polypeptide binding]; other site 1197719008664 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1197719008665 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1197719008666 active site 1197719008667 intersubunit interface [polypeptide binding]; other site 1197719008668 zinc binding site [ion binding]; other site 1197719008669 Na+ binding site [ion binding]; other site 1197719008670 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1197719008671 Phosphoglycerate kinase; Region: PGK; pfam00162 1197719008672 substrate binding site [chemical binding]; other site 1197719008673 hinge regions; other site 1197719008674 ADP binding site [chemical binding]; other site 1197719008675 catalytic site [active] 1197719008676 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1197719008677 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1197719008678 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1197719008679 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1197719008680 trimer interface [polypeptide binding]; other site 1197719008681 putative Zn binding site [ion binding]; other site 1197719008682 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1197719008683 hypothetical protein; Provisional; Region: PRK09609 1197719008684 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1197719008685 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1197719008686 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1197719008687 Walker A/P-loop; other site 1197719008688 ATP binding site [chemical binding]; other site 1197719008689 Q-loop/lid; other site 1197719008690 ABC transporter signature motif; other site 1197719008691 Walker B; other site 1197719008692 D-loop; other site 1197719008693 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1197719008694 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1197719008695 active site 1197719008696 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1197719008697 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 1197719008698 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1197719008699 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1197719008700 putative active site [active] 1197719008701 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1197719008702 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1197719008703 putative NAD(P) binding site [chemical binding]; other site 1197719008704 catalytic Zn binding site [ion binding]; other site 1197719008705 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1197719008706 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1197719008707 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1197719008708 active site 1197719008709 P-loop; other site 1197719008710 phosphorylation site [posttranslational modification] 1197719008711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719008712 active site 1197719008713 phosphorylation site [posttranslational modification] 1197719008714 transketolase; Reviewed; Region: PRK12753 1197719008715 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1197719008716 TPP-binding site [chemical binding]; other site 1197719008717 dimer interface [polypeptide binding]; other site 1197719008718 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1197719008719 PYR/PP interface [polypeptide binding]; other site 1197719008720 dimer interface [polypeptide binding]; other site 1197719008721 TPP binding site [chemical binding]; other site 1197719008722 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1197719008723 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1197719008724 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1197719008725 agmatinase; Region: agmatinase; TIGR01230 1197719008726 oligomer interface [polypeptide binding]; other site 1197719008727 putative active site [active] 1197719008728 Mn binding site [ion binding]; other site 1197719008729 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1197719008730 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1197719008731 dimer interface [polypeptide binding]; other site 1197719008732 active site 1197719008733 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1197719008734 catalytic residues [active] 1197719008735 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1197719008736 Virulence promoting factor; Region: YqgB; pfam11036 1197719008737 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1197719008738 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1197719008739 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1197719008740 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1197719008741 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1197719008742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008743 putative substrate translocation pore; other site 1197719008744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008745 hypothetical protein; Provisional; Region: PRK04860 1197719008746 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1197719008747 DNA-specific endonuclease I; Provisional; Region: PRK15137 1197719008748 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1197719008749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1197719008750 RNA methyltransferase, RsmE family; Region: TIGR00046 1197719008751 glutathione synthetase; Provisional; Region: PRK05246 1197719008752 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1197719008753 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1197719008754 hypothetical protein; Validated; Region: PRK00228 1197719008755 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1197719008756 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1197719008757 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1197719008758 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1197719008759 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1197719008760 Walker A motif; other site 1197719008761 ATP binding site [chemical binding]; other site 1197719008762 Walker B motif; other site 1197719008763 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1197719008764 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1197719008765 catalytic residue [active] 1197719008766 YGGT family; Region: YGGT; pfam02325 1197719008767 YGGT family; Region: YGGT; pfam02325 1197719008768 hypothetical protein; Validated; Region: PRK05090 1197719008769 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1197719008770 active site 1197719008771 dimerization interface [polypeptide binding]; other site 1197719008772 HemN family oxidoreductase; Provisional; Region: PRK05660 1197719008773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719008774 FeS/SAM binding site; other site 1197719008775 HemN C-terminal domain; Region: HemN_C; pfam06969 1197719008776 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1197719008777 homodimer interface [polypeptide binding]; other site 1197719008778 active site 1197719008779 hypothetical protein; Provisional; Region: PRK10626 1197719008780 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1197719008781 hypothetical protein; Provisional; Region: PRK11702 1197719008782 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1197719008783 adenine DNA glycosylase; Provisional; Region: PRK10880 1197719008784 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1197719008785 minor groove reading motif; other site 1197719008786 helix-hairpin-helix signature motif; other site 1197719008787 substrate binding pocket [chemical binding]; other site 1197719008788 active site 1197719008789 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1197719008790 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1197719008791 DNA binding and oxoG recognition site [nucleotide binding] 1197719008792 oxidative damage protection protein; Provisional; Region: PRK05408 1197719008793 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1197719008794 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1197719008795 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719008796 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719008797 catalytic residue [active] 1197719008798 nucleoside transporter; Region: 2A0110; TIGR00889 1197719008799 ornithine decarboxylase; Provisional; Region: PRK13578 1197719008800 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1197719008801 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1197719008802 homodimer interface [polypeptide binding]; other site 1197719008803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719008804 catalytic residue [active] 1197719008805 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1197719008806 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1197719008807 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1197719008808 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1197719008809 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1197719008810 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1197719008811 conserved hypothetical protein; Region: TIGR02270 1197719008812 conserved hypothetical protein; Region: TIGR02270 1197719008813 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1197719008814 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1197719008815 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1197719008816 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1197719008817 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1197719008818 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1197719008819 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1197719008820 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1197719008821 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1197719008822 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1197719008823 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1197719008824 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1197719008825 Protein of unknown function (DUF796); Region: DUF796; cl01226 1197719008826 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1197719008827 active site 1197719008828 catalytic site [active] 1197719008829 Zn binding site [ion binding]; other site 1197719008830 tetramer interface [polypeptide binding]; other site 1197719008831 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1197719008832 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1197719008833 putative active site [active] 1197719008834 catalytic triad [active] 1197719008835 putative dimer interface [polypeptide binding]; other site 1197719008836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719008837 D-galactonate transporter; Region: 2A0114; TIGR00893 1197719008838 putative substrate translocation pore; other site 1197719008839 mannonate dehydratase; Provisional; Region: PRK03906 1197719008840 mannonate dehydratase; Region: uxuA; TIGR00695 1197719008841 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1197719008842 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1197719008843 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1197719008844 Glucuronate isomerase; Region: UxaC; pfam02614 1197719008845 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1197719008846 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1197719008847 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1197719008848 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1197719008849 active site 1197719008850 putative symporter YagG; Provisional; Region: PRK09669 1197719008851 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1197719008852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719008853 dimer interface [polypeptide binding]; other site 1197719008854 putative CheW interface [polypeptide binding]; other site 1197719008855 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1197719008856 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1197719008857 CHAP domain; Region: CHAP; pfam05257 1197719008858 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1197719008859 putative S-transferase; Provisional; Region: PRK11752 1197719008860 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1197719008861 C-terminal domain interface [polypeptide binding]; other site 1197719008862 GSH binding site (G-site) [chemical binding]; other site 1197719008863 dimer interface [polypeptide binding]; other site 1197719008864 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1197719008865 dimer interface [polypeptide binding]; other site 1197719008866 N-terminal domain interface [polypeptide binding]; other site 1197719008867 active site 1197719008868 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1197719008869 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1197719008870 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1197719008871 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1197719008872 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1197719008873 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1197719008874 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1197719008875 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1197719008876 putative substrate-binding site; other site 1197719008877 nickel binding site [ion binding]; other site 1197719008878 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1197719008879 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1197719008880 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1197719008881 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1197719008882 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1197719008883 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1197719008884 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1197719008885 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1197719008886 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1197719008887 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1197719008888 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1197719008889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719008890 dimerization interface [polypeptide binding]; other site 1197719008891 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719008892 dimer interface [polypeptide binding]; other site 1197719008893 putative CheW interface [polypeptide binding]; other site 1197719008894 hypothetical protein; Provisional; Region: PRK05208 1197719008895 oxidoreductase; Provisional; Region: PRK07985 1197719008896 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1197719008897 NAD binding site [chemical binding]; other site 1197719008898 metal binding site [ion binding]; metal-binding site 1197719008899 active site 1197719008900 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1197719008901 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1197719008902 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1197719008903 cystathionine beta-lyase; Provisional; Region: PRK08114 1197719008904 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1197719008905 homodimer interface [polypeptide binding]; other site 1197719008906 substrate-cofactor binding pocket; other site 1197719008907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719008908 catalytic residue [active] 1197719008909 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1197719008910 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1197719008911 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1197719008912 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1197719008913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719008914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719008915 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1197719008916 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1197719008917 dimer interface [polypeptide binding]; other site 1197719008918 active site 1197719008919 metal binding site [ion binding]; metal-binding site 1197719008920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1197719008921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1197719008922 active site 1197719008923 catalytic tetrad [active] 1197719008924 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719008925 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1197719008926 transmembrane helices; other site 1197719008927 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1197719008928 nucleotide binding site/active site [active] 1197719008929 hypothetical protein; Provisional; Region: PRK01254 1197719008930 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1197719008931 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1197719008932 FtsI repressor; Provisional; Region: PRK10883 1197719008933 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1197719008934 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1197719008935 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1197719008936 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1197719008937 putative acyl-acceptor binding pocket; other site 1197719008938 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1197719008939 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1197719008940 CAP-like domain; other site 1197719008941 active site 1197719008942 primary dimer interface [polypeptide binding]; other site 1197719008943 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1197719008944 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1197719008945 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1197719008946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719008947 active site 1197719008948 phosphorylation site [posttranslational modification] 1197719008949 intermolecular recognition site; other site 1197719008950 dimerization interface [polypeptide binding]; other site 1197719008951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719008952 DNA binding site [nucleotide binding] 1197719008953 sensor protein QseC; Provisional; Region: PRK10337 1197719008954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719008955 dimer interface [polypeptide binding]; other site 1197719008956 phosphorylation site [posttranslational modification] 1197719008957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719008958 ATP binding site [chemical binding]; other site 1197719008959 Mg2+ binding site [ion binding]; other site 1197719008960 G-X-G motif; other site 1197719008961 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1197719008962 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1197719008963 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1197719008964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719008965 ATP binding site [chemical binding]; other site 1197719008966 Mg2+ binding site [ion binding]; other site 1197719008967 G-X-G motif; other site 1197719008968 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1197719008969 anchoring element; other site 1197719008970 dimer interface [polypeptide binding]; other site 1197719008971 ATP binding site [chemical binding]; other site 1197719008972 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1197719008973 active site 1197719008974 metal binding site [ion binding]; metal-binding site 1197719008975 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1197719008976 esterase YqiA; Provisional; Region: PRK11071 1197719008977 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1197719008978 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1197719008979 active site 1197719008980 metal binding site [ion binding]; metal-binding site 1197719008981 hexamer interface [polypeptide binding]; other site 1197719008982 putative dehydrogenase; Provisional; Region: PRK11039 1197719008983 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1197719008984 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1197719008985 dimer interface [polypeptide binding]; other site 1197719008986 ADP-ribose binding site [chemical binding]; other site 1197719008987 active site 1197719008988 nudix motif; other site 1197719008989 metal binding site [ion binding]; metal-binding site 1197719008990 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1197719008991 hypothetical protein; Provisional; Region: PRK11653 1197719008992 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1197719008993 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1197719008994 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1197719008995 putative active site [active] 1197719008996 metal binding site [ion binding]; metal-binding site 1197719008997 zinc transporter ZupT; Provisional; Region: PRK04201 1197719008998 ZIP Zinc transporter; Region: Zip; pfam02535 1197719008999 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1197719009000 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1197719009001 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1197719009002 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1197719009003 catalytic residues [active] 1197719009004 hinge region; other site 1197719009005 alpha helical domain; other site 1197719009006 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1197719009007 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1197719009008 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1197719009009 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1197719009010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1197719009011 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1197719009012 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1197719009013 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1197719009014 putative ribose interaction site [chemical binding]; other site 1197719009015 putative ADP binding site [chemical binding]; other site 1197719009016 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1197719009017 active site 1197719009018 nucleotide binding site [chemical binding]; other site 1197719009019 HIGH motif; other site 1197719009020 KMSKS motif; other site 1197719009021 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1197719009022 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1197719009023 metal binding triad; other site 1197719009024 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1197719009025 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1197719009026 metal binding triad; other site 1197719009027 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1197719009028 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1197719009029 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1197719009030 putative active site [active] 1197719009031 putative metal binding residues [ion binding]; other site 1197719009032 signature motif; other site 1197719009033 putative triphosphate binding site [ion binding]; other site 1197719009034 CHAD domain; Region: CHAD; pfam05235 1197719009035 SH3 domain-containing protein; Provisional; Region: PRK10884 1197719009036 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1197719009037 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1197719009038 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1197719009039 active site 1197719009040 NTP binding site [chemical binding]; other site 1197719009041 metal binding triad [ion binding]; metal-binding site 1197719009042 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1197719009043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1197719009044 Zn2+ binding site [ion binding]; other site 1197719009045 Mg2+ binding site [ion binding]; other site 1197719009046 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1197719009047 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1197719009048 homooctamer interface [polypeptide binding]; other site 1197719009049 active site 1197719009050 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1197719009051 transcriptional activator TtdR; Provisional; Region: PRK09801 1197719009052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719009053 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1197719009054 putative effector binding pocket; other site 1197719009055 putative dimerization interface [polypeptide binding]; other site 1197719009056 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1197719009057 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1197719009058 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719009059 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1197719009060 transmembrane helices; other site 1197719009061 UGMP family protein; Validated; Region: PRK09604 1197719009062 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1197719009063 DNA primase; Validated; Region: dnaG; PRK05667 1197719009064 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1197719009065 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1197719009066 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1197719009067 active site 1197719009068 metal binding site [ion binding]; metal-binding site 1197719009069 interdomain interaction site; other site 1197719009070 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1197719009071 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1197719009072 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1197719009073 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1197719009074 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1197719009075 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1197719009076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1197719009077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1197719009078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1197719009079 DNA binding residues [nucleotide binding] 1197719009080 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1197719009081 active site 1197719009082 SUMO-1 interface [polypeptide binding]; other site 1197719009083 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1197719009084 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1197719009085 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1197719009086 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1197719009087 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1197719009088 Baseplate J-like protein; Region: Baseplate_J; cl01294 1197719009089 Baseplate J-like protein; Region: Baseplate_J; pfam04865 1197719009090 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 1197719009091 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1197719009092 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 1197719009093 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1197719009094 Phage holin family 2; Region: Phage_holin_2; pfam04550 1197719009095 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 1197719009096 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 1197719009097 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1197719009098 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1197719009099 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1197719009100 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1197719009101 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1197719009102 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1197719009103 terminase ATPase subunit; Provisional; Region: P; PHA02535 1197719009104 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1197719009105 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1197719009106 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1197719009107 Phage portal protein; Region: Phage_portal; pfam04860 1197719009108 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1197719009109 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 1197719009110 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1197719009111 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1197719009112 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1197719009113 threonine ammonia-lyase, medium form; Region: ilvA_1Cterm; TIGR01127 1197719009114 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 1197719009115 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1197719009116 WYL domain; Region: WYL; pfam13280 1197719009117 integrase; Provisional; Region: int; PHA02601 1197719009118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719009119 active site 1197719009120 DNA binding site [nucleotide binding] 1197719009121 Int/Topo IB signature motif; other site 1197719009122 YecR-like lipoprotein; Region: YecR; cl10256 1197719009123 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1197719009124 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1197719009125 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1197719009126 FAD binding pocket [chemical binding]; other site 1197719009127 FAD binding motif [chemical binding]; other site 1197719009128 phosphate binding motif [ion binding]; other site 1197719009129 NAD binding pocket [chemical binding]; other site 1197719009130 Predicted transcriptional regulators [Transcription]; Region: COG1695 1197719009131 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1197719009132 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1197719009133 Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998 1197719009134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719009135 dimerization interface [polypeptide binding]; other site 1197719009136 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1197719009137 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719009138 dimer interface [polypeptide binding]; other site 1197719009139 putative CheW interface [polypeptide binding]; other site 1197719009140 PAS fold; Region: PAS_3; pfam08447 1197719009141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719009142 putative active site [active] 1197719009143 heme pocket [chemical binding]; other site 1197719009144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1197719009145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719009146 dimer interface [polypeptide binding]; other site 1197719009147 putative CheW interface [polypeptide binding]; other site 1197719009148 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1197719009149 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1197719009150 inhibitor-cofactor binding pocket; inhibition site 1197719009151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719009152 catalytic residue [active] 1197719009153 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1197719009154 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1197719009155 active site 1197719009156 FMN binding site [chemical binding]; other site 1197719009157 2,4-decadienoyl-CoA binding site; other site 1197719009158 catalytic residue [active] 1197719009159 4Fe-4S cluster binding site [ion binding]; other site 1197719009160 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1197719009161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719009162 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1197719009163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719009164 S-adenosylmethionine binding site [chemical binding]; other site 1197719009165 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1197719009166 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1197719009167 putative active site [active] 1197719009168 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1197719009169 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1197719009170 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1197719009171 serine/threonine transporter SstT; Provisional; Region: PRK13628 1197719009172 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1197719009173 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1197719009174 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1197719009175 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1197719009176 Glucuronate isomerase; Region: UxaC; pfam02614 1197719009177 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1197719009178 D-galactonate transporter; Region: 2A0114; TIGR00893 1197719009179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719009180 putative substrate translocation pore; other site 1197719009181 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1197719009182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719009183 DNA-binding site [nucleotide binding]; DNA binding site 1197719009184 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1197719009185 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1197719009186 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1197719009187 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1197719009188 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1197719009189 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1197719009190 Predicted membrane protein [Function unknown]; Region: COG5393 1197719009191 YqjK-like protein; Region: YqjK; pfam13997 1197719009192 Predicted membrane protein [Function unknown]; Region: COG2259 1197719009193 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1197719009194 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1197719009195 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1197719009196 putative dimer interface [polypeptide binding]; other site 1197719009197 N-terminal domain interface [polypeptide binding]; other site 1197719009198 putative substrate binding pocket (H-site) [chemical binding]; other site 1197719009199 Predicted membrane protein [Function unknown]; Region: COG3152 1197719009200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719009201 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1197719009202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719009203 dimerization interface [polypeptide binding]; other site 1197719009204 Pirin-related protein [General function prediction only]; Region: COG1741 1197719009205 Pirin; Region: Pirin; pfam02678 1197719009206 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1197719009207 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1197719009208 serine transporter; Region: stp; TIGR00814 1197719009209 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1197719009210 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1197719009211 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1197719009212 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1197719009213 Pyruvate formate lyase 1; Region: PFL1; cd01678 1197719009214 coenzyme A binding site [chemical binding]; other site 1197719009215 active site 1197719009216 catalytic residues [active] 1197719009217 glycine loop; other site 1197719009218 propionate/acetate kinase; Provisional; Region: PRK12379 1197719009219 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1197719009220 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1197719009221 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1197719009222 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1197719009223 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1197719009224 tetramer interface [polypeptide binding]; other site 1197719009225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719009226 catalytic residue [active] 1197719009227 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1197719009228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719009229 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1197719009230 putative substrate binding pocket [chemical binding]; other site 1197719009231 putative dimerization interface [polypeptide binding]; other site 1197719009232 glycerate kinase I; Provisional; Region: PRK10342 1197719009233 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1197719009234 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1197719009235 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1197719009236 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1197719009237 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1197719009238 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1197719009239 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1197719009240 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1197719009241 intersubunit interface [polypeptide binding]; other site 1197719009242 active site 1197719009243 zinc binding site [ion binding]; other site 1197719009244 Na+ binding site [ion binding]; other site 1197719009245 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1197719009246 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719009247 active site 1197719009248 phosphorylation site [posttranslational modification] 1197719009249 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1197719009250 active site 1197719009251 P-loop; other site 1197719009252 phosphorylation site [posttranslational modification] 1197719009253 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1197719009254 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1197719009255 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1197719009256 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1197719009257 putative NAD(P) binding site [chemical binding]; other site 1197719009258 catalytic Zn binding site [ion binding]; other site 1197719009259 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719009260 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1197719009261 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719009262 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1197719009263 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1197719009264 putative SAM binding site [chemical binding]; other site 1197719009265 putative homodimer interface [polypeptide binding]; other site 1197719009266 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1197719009267 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1197719009268 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1197719009269 putative ligand binding site [chemical binding]; other site 1197719009270 TIGR00252 family protein; Region: TIGR00252 1197719009271 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1197719009272 dimer interface [polypeptide binding]; other site 1197719009273 active site 1197719009274 outer membrane lipoprotein; Provisional; Region: PRK11023 1197719009275 BON domain; Region: BON; pfam04972 1197719009276 BON domain; Region: BON; pfam04972 1197719009277 Predicted permease; Region: DUF318; pfam03773 1197719009278 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1197719009279 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1197719009280 NAD binding site [chemical binding]; other site 1197719009281 active site 1197719009282 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1197719009283 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1197719009284 proposed catalytic triad [active] 1197719009285 conserved cys residue [active] 1197719009286 hypothetical protein; Provisional; Region: PRK03467 1197719009287 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1197719009288 GIY-YIG motif/motif A; other site 1197719009289 putative active site [active] 1197719009290 putative metal binding site [ion binding]; other site 1197719009291 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1197719009292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719009293 Coenzyme A binding pocket [chemical binding]; other site 1197719009294 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1197719009295 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1197719009296 Peptidase family U32; Region: Peptidase_U32; pfam01136 1197719009297 putative protease; Provisional; Region: PRK15447 1197719009298 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1197719009299 hypothetical protein; Provisional; Region: PRK10508 1197719009300 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1197719009301 tryptophan permease; Provisional; Region: PRK10483 1197719009302 aromatic amino acid transport protein; Region: araaP; TIGR00837 1197719009303 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1197719009304 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1197719009305 ATP binding site [chemical binding]; other site 1197719009306 Mg++ binding site [ion binding]; other site 1197719009307 motif III; other site 1197719009308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719009309 nucleotide binding region [chemical binding]; other site 1197719009310 ATP-binding site [chemical binding]; other site 1197719009311 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1197719009312 putative RNA binding site [nucleotide binding]; other site 1197719009313 lipoprotein NlpI; Provisional; Region: PRK11189 1197719009314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719009315 binding surface 1197719009316 TPR motif; other site 1197719009317 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1197719009318 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1197719009319 RNase E interface [polypeptide binding]; other site 1197719009320 trimer interface [polypeptide binding]; other site 1197719009321 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1197719009322 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1197719009323 RNase E interface [polypeptide binding]; other site 1197719009324 trimer interface [polypeptide binding]; other site 1197719009325 active site 1197719009326 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1197719009327 putative nucleic acid binding region [nucleotide binding]; other site 1197719009328 G-X-X-G motif; other site 1197719009329 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1197719009330 RNA binding site [nucleotide binding]; other site 1197719009331 domain interface; other site 1197719009332 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1197719009333 16S/18S rRNA binding site [nucleotide binding]; other site 1197719009334 S13e-L30e interaction site [polypeptide binding]; other site 1197719009335 25S rRNA binding site [nucleotide binding]; other site 1197719009336 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1197719009337 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1197719009338 RNA binding site [nucleotide binding]; other site 1197719009339 active site 1197719009340 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1197719009341 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1197719009342 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1197719009343 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1197719009344 translation initiation factor IF-2; Region: IF-2; TIGR00487 1197719009345 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1197719009346 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1197719009347 G1 box; other site 1197719009348 putative GEF interaction site [polypeptide binding]; other site 1197719009349 GTP/Mg2+ binding site [chemical binding]; other site 1197719009350 Switch I region; other site 1197719009351 G2 box; other site 1197719009352 G3 box; other site 1197719009353 Switch II region; other site 1197719009354 G4 box; other site 1197719009355 G5 box; other site 1197719009356 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1197719009357 Translation-initiation factor 2; Region: IF-2; pfam11987 1197719009358 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1197719009359 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1197719009360 NusA N-terminal domain; Region: NusA_N; pfam08529 1197719009361 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1197719009362 RNA binding site [nucleotide binding]; other site 1197719009363 homodimer interface [polypeptide binding]; other site 1197719009364 NusA-like KH domain; Region: KH_5; pfam13184 1197719009365 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1197719009366 G-X-X-G motif; other site 1197719009367 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1197719009368 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1197719009369 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 1197719009370 hypothetical protein; Provisional; Region: PRK14641 1197719009371 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1197719009372 putative oligomer interface [polypeptide binding]; other site 1197719009373 putative RNA binding site [nucleotide binding]; other site 1197719009374 argininosuccinate synthase; Validated; Region: PRK05370 1197719009375 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1197719009376 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1197719009377 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1197719009378 active site 1197719009379 substrate binding site [chemical binding]; other site 1197719009380 metal binding site [ion binding]; metal-binding site 1197719009381 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1197719009382 dihydropteroate synthase; Region: DHPS; TIGR01496 1197719009383 substrate binding pocket [chemical binding]; other site 1197719009384 dimer interface [polypeptide binding]; other site 1197719009385 inhibitor binding site; inhibition site 1197719009386 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1197719009387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719009388 Walker A motif; other site 1197719009389 ATP binding site [chemical binding]; other site 1197719009390 Walker B motif; other site 1197719009391 arginine finger; other site 1197719009392 Peptidase family M41; Region: Peptidase_M41; pfam01434 1197719009393 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1197719009394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719009395 S-adenosylmethionine binding site [chemical binding]; other site 1197719009396 RNA-binding protein YhbY; Provisional; Region: PRK10343 1197719009397 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1197719009398 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1197719009399 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1197719009400 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1197719009401 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1197719009402 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1197719009403 GTP1/OBG; Region: GTP1_OBG; pfam01018 1197719009404 Obg GTPase; Region: Obg; cd01898 1197719009405 G1 box; other site 1197719009406 GTP/Mg2+ binding site [chemical binding]; other site 1197719009407 Switch I region; other site 1197719009408 G2 box; other site 1197719009409 G3 box; other site 1197719009410 Switch II region; other site 1197719009411 G4 box; other site 1197719009412 G5 box; other site 1197719009413 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1197719009414 EamA-like transporter family; Region: EamA; pfam00892 1197719009415 EamA-like transporter family; Region: EamA; pfam00892 1197719009416 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1197719009417 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1197719009418 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1197719009419 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1197719009420 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1197719009421 substrate binding pocket [chemical binding]; other site 1197719009422 chain length determination region; other site 1197719009423 substrate-Mg2+ binding site; other site 1197719009424 catalytic residues [active] 1197719009425 aspartate-rich region 1; other site 1197719009426 active site lid residues [active] 1197719009427 aspartate-rich region 2; other site 1197719009428 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1197719009429 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1197719009430 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1197719009431 hinge; other site 1197719009432 active site 1197719009433 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1197719009434 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1197719009435 anti sigma factor interaction site; other site 1197719009436 regulatory phosphorylation site [posttranslational modification]; other site 1197719009437 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1197719009438 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1197719009439 mce related protein; Region: MCE; pfam02470 1197719009440 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1197719009441 conserved hypothetical integral membrane protein; Region: TIGR00056 1197719009442 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1197719009443 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1197719009444 Walker A/P-loop; other site 1197719009445 ATP binding site [chemical binding]; other site 1197719009446 Q-loop/lid; other site 1197719009447 ABC transporter signature motif; other site 1197719009448 Walker B; other site 1197719009449 D-loop; other site 1197719009450 H-loop/switch region; other site 1197719009451 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1197719009452 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1197719009453 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1197719009454 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1197719009455 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1197719009456 putative active site [active] 1197719009457 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1197719009458 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1197719009459 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1197719009460 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1197719009461 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1197719009462 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1197719009463 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1197719009464 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1197719009465 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1197719009466 Walker A/P-loop; other site 1197719009467 ATP binding site [chemical binding]; other site 1197719009468 Q-loop/lid; other site 1197719009469 ABC transporter signature motif; other site 1197719009470 Walker B; other site 1197719009471 D-loop; other site 1197719009472 H-loop/switch region; other site 1197719009473 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1197719009474 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1197719009475 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1197719009476 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1197719009477 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1197719009478 30S subunit binding site; other site 1197719009479 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719009480 active site 1197719009481 phosphorylation site [posttranslational modification] 1197719009482 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1197719009483 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1197719009484 dimerization domain swap beta strand [polypeptide binding]; other site 1197719009485 regulatory protein interface [polypeptide binding]; other site 1197719009486 active site 1197719009487 regulatory phosphorylation site [posttranslational modification]; other site 1197719009488 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 1197719009489 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1197719009490 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1197719009491 Transglycosylase; Region: Transgly; cl17702 1197719009492 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1197719009493 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1197719009494 conserved cys residue [active] 1197719009495 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1197719009496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719009497 putative active site [active] 1197719009498 heme pocket [chemical binding]; other site 1197719009499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719009500 dimer interface [polypeptide binding]; other site 1197719009501 phosphorylation site [posttranslational modification] 1197719009502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719009503 ATP binding site [chemical binding]; other site 1197719009504 Mg2+ binding site [ion binding]; other site 1197719009505 G-X-G motif; other site 1197719009506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719009507 active site 1197719009508 phosphorylation site [posttranslational modification] 1197719009509 intermolecular recognition site; other site 1197719009510 dimerization interface [polypeptide binding]; other site 1197719009511 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1197719009512 putative binding surface; other site 1197719009513 active site 1197719009514 radical SAM protein, TIGR01212 family; Region: TIGR01212 1197719009515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719009516 FeS/SAM binding site; other site 1197719009517 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1197719009518 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1197719009519 active site 1197719009520 dimer interface [polypeptide binding]; other site 1197719009521 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1197719009522 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1197719009523 active site 1197719009524 FMN binding site [chemical binding]; other site 1197719009525 substrate binding site [chemical binding]; other site 1197719009526 3Fe-4S cluster binding site [ion binding]; other site 1197719009527 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1197719009528 domain interface; other site 1197719009529 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1197719009530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719009531 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719009532 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1197719009533 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1197719009534 Na binding site [ion binding]; other site 1197719009535 putative substrate binding site [chemical binding]; other site 1197719009536 cytosine deaminase; Provisional; Region: PRK09230 1197719009537 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1197719009538 active site 1197719009539 Domain of unknown function (DUF386); Region: DUF386; cl01047 1197719009540 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1197719009541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1197719009542 nucleotide binding site [chemical binding]; other site 1197719009543 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1197719009544 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1197719009545 putative active site cavity [active] 1197719009546 putative sialic acid transporter; Provisional; Region: PRK03893 1197719009547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719009548 putative substrate translocation pore; other site 1197719009549 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1197719009550 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1197719009551 inhibitor site; inhibition site 1197719009552 active site 1197719009553 dimer interface [polypeptide binding]; other site 1197719009554 catalytic residue [active] 1197719009555 transcriptional regulator NanR; Provisional; Region: PRK03837 1197719009556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719009557 DNA-binding site [nucleotide binding]; DNA binding site 1197719009558 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1197719009559 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1197719009560 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1197719009561 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1197719009562 C-terminal domain interface [polypeptide binding]; other site 1197719009563 putative GSH binding site (G-site) [chemical binding]; other site 1197719009564 dimer interface [polypeptide binding]; other site 1197719009565 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1197719009566 dimer interface [polypeptide binding]; other site 1197719009567 N-terminal domain interface [polypeptide binding]; other site 1197719009568 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1197719009569 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1197719009570 23S rRNA interface [nucleotide binding]; other site 1197719009571 L3 interface [polypeptide binding]; other site 1197719009572 Predicted ATPase [General function prediction only]; Region: COG1485 1197719009573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1197719009574 hypothetical protein; Provisional; Region: PRK11677 1197719009575 serine endoprotease; Provisional; Region: PRK10139 1197719009576 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1197719009577 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1197719009578 protein binding site [polypeptide binding]; other site 1197719009579 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1197719009580 serine endoprotease; Provisional; Region: PRK10898 1197719009581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1197719009582 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1197719009583 malate dehydrogenase; Provisional; Region: PRK05086 1197719009584 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1197719009585 NAD binding site [chemical binding]; other site 1197719009586 dimerization interface [polypeptide binding]; other site 1197719009587 Substrate binding site [chemical binding]; other site 1197719009588 arginine repressor; Provisional; Region: PRK05066 1197719009589 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1197719009590 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1197719009591 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719009592 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719009593 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1197719009594 RNAase interaction site [polypeptide binding]; other site 1197719009595 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1197719009596 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1197719009597 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1197719009598 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719009599 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719009600 efflux system membrane protein; Provisional; Region: PRK11594 1197719009601 transcriptional regulator; Provisional; Region: PRK10632 1197719009602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719009603 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1197719009604 putative effector binding pocket; other site 1197719009605 dimerization interface [polypeptide binding]; other site 1197719009606 protease TldD; Provisional; Region: tldD; PRK10735 1197719009607 hypothetical protein; Provisional; Region: PRK10899 1197719009608 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1197719009609 ribonuclease G; Provisional; Region: PRK11712 1197719009610 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1197719009611 homodimer interface [polypeptide binding]; other site 1197719009612 oligonucleotide binding site [chemical binding]; other site 1197719009613 Maf-like protein; Region: Maf; pfam02545 1197719009614 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1197719009615 active site 1197719009616 dimer interface [polypeptide binding]; other site 1197719009617 rod shape-determining protein MreD; Provisional; Region: PRK11060 1197719009618 rod shape-determining protein MreC; Region: mreC; TIGR00219 1197719009619 rod shape-determining protein MreC; Region: MreC; pfam04085 1197719009620 rod shape-determining protein MreB; Provisional; Region: PRK13927 1197719009621 MreB and similar proteins; Region: MreB_like; cd10225 1197719009622 nucleotide binding site [chemical binding]; other site 1197719009623 Mg binding site [ion binding]; other site 1197719009624 putative protofilament interaction site [polypeptide binding]; other site 1197719009625 RodZ interaction site [polypeptide binding]; other site 1197719009626 regulatory protein CsrD; Provisional; Region: PRK11059 1197719009627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719009628 metal binding site [ion binding]; metal-binding site 1197719009629 active site 1197719009630 I-site; other site 1197719009631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719009632 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1197719009633 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1197719009634 NADP binding site [chemical binding]; other site 1197719009635 dimer interface [polypeptide binding]; other site 1197719009636 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1197719009637 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1197719009638 Moco binding site; other site 1197719009639 metal coordination site [ion binding]; other site 1197719009640 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1197719009641 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1197719009642 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1197719009643 carboxyltransferase (CT) interaction site; other site 1197719009644 biotinylation site [posttranslational modification]; other site 1197719009645 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1197719009646 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1197719009647 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1197719009648 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1197719009649 hypothetical protein; Provisional; Region: PRK10633 1197719009650 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1197719009651 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1197719009652 Na binding site [ion binding]; other site 1197719009653 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1197719009654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1197719009655 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1197719009656 active site 1197719009657 zinc binding site [ion binding]; other site 1197719009658 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1197719009659 active site 1197719009660 FMN binding site [chemical binding]; other site 1197719009661 catalytic residues [active] 1197719009662 substrate binding site [chemical binding]; other site 1197719009663 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1197719009664 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1197719009665 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1197719009666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719009667 DNA methylase; Region: N6_N4_Mtase; pfam01555 1197719009668 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1197719009669 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1197719009670 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1197719009671 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1197719009672 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719009673 metal binding site [ion binding]; metal-binding site 1197719009674 active site 1197719009675 I-site; other site 1197719009676 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719009677 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1197719009678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719009679 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1197719009680 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1197719009681 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719009682 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719009683 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1197719009684 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1197719009685 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1197719009686 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1197719009687 trimer interface [polypeptide binding]; other site 1197719009688 putative metal binding site [ion binding]; other site 1197719009689 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1197719009690 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1197719009691 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1197719009692 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1197719009693 shikimate binding site; other site 1197719009694 NAD(P) binding site [chemical binding]; other site 1197719009695 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1197719009696 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1197719009697 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1197719009698 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1197719009699 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1197719009700 hypothetical protein; Validated; Region: PRK03430 1197719009701 hypothetical protein; Provisional; Region: PRK10736 1197719009702 DNA protecting protein DprA; Region: dprA; TIGR00732 1197719009703 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1197719009704 active site 1197719009705 catalytic residues [active] 1197719009706 metal binding site [ion binding]; metal-binding site 1197719009707 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1197719009708 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1197719009709 putative active site [active] 1197719009710 substrate binding site [chemical binding]; other site 1197719009711 putative cosubstrate binding site; other site 1197719009712 catalytic site [active] 1197719009713 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1197719009714 substrate binding site [chemical binding]; other site 1197719009715 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1197719009716 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1197719009717 putative RNA binding site [nucleotide binding]; other site 1197719009718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719009719 S-adenosylmethionine binding site [chemical binding]; other site 1197719009720 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1197719009721 TrkA-N domain; Region: TrkA_N; pfam02254 1197719009722 TrkA-C domain; Region: TrkA_C; pfam02080 1197719009723 TrkA-N domain; Region: TrkA_N; pfam02254 1197719009724 TrkA-C domain; Region: TrkA_C; pfam02080 1197719009725 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1197719009726 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1197719009727 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1197719009728 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1197719009729 DNA binding residues [nucleotide binding] 1197719009730 dimer interface [polypeptide binding]; other site 1197719009731 metal binding site [ion binding]; metal-binding site 1197719009732 hypothetical protein; Provisional; Region: PRK10203 1197719009733 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1197719009734 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1197719009735 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1197719009736 alphaNTD homodimer interface [polypeptide binding]; other site 1197719009737 alphaNTD - beta interaction site [polypeptide binding]; other site 1197719009738 alphaNTD - beta' interaction site [polypeptide binding]; other site 1197719009739 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1197719009740 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1197719009741 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1197719009742 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719009743 RNA binding surface [nucleotide binding]; other site 1197719009744 30S ribosomal protein S11; Validated; Region: PRK05309 1197719009745 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1197719009746 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1197719009747 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1197719009748 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1197719009749 SecY translocase; Region: SecY; pfam00344 1197719009750 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1197719009751 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1197719009752 23S rRNA binding site [nucleotide binding]; other site 1197719009753 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1197719009754 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1197719009755 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1197719009756 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1197719009757 23S rRNA interface [nucleotide binding]; other site 1197719009758 5S rRNA interface [nucleotide binding]; other site 1197719009759 L27 interface [polypeptide binding]; other site 1197719009760 L5 interface [polypeptide binding]; other site 1197719009761 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1197719009762 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1197719009763 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1197719009764 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1197719009765 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1197719009766 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1197719009767 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1197719009768 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1197719009769 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1197719009770 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1197719009771 RNA binding site [nucleotide binding]; other site 1197719009772 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1197719009773 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1197719009774 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1197719009775 23S rRNA interface [nucleotide binding]; other site 1197719009776 putative translocon interaction site; other site 1197719009777 signal recognition particle (SRP54) interaction site; other site 1197719009778 L23 interface [polypeptide binding]; other site 1197719009779 trigger factor interaction site; other site 1197719009780 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1197719009781 23S rRNA interface [nucleotide binding]; other site 1197719009782 5S rRNA interface [nucleotide binding]; other site 1197719009783 putative antibiotic binding site [chemical binding]; other site 1197719009784 L25 interface [polypeptide binding]; other site 1197719009785 L27 interface [polypeptide binding]; other site 1197719009786 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1197719009787 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1197719009788 G-X-X-G motif; other site 1197719009789 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1197719009790 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1197719009791 protein-rRNA interface [nucleotide binding]; other site 1197719009792 putative translocon binding site; other site 1197719009793 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1197719009794 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1197719009795 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1197719009796 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1197719009797 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1197719009798 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1197719009799 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1197719009800 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1197719009801 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1197719009802 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1197719009803 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1197719009804 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1197719009805 heme binding site [chemical binding]; other site 1197719009806 ferroxidase pore; other site 1197719009807 ferroxidase diiron center [ion binding]; other site 1197719009808 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1197719009809 elongation factor Tu; Reviewed; Region: PRK00049 1197719009810 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1197719009811 G1 box; other site 1197719009812 GEF interaction site [polypeptide binding]; other site 1197719009813 GTP/Mg2+ binding site [chemical binding]; other site 1197719009814 Switch I region; other site 1197719009815 G2 box; other site 1197719009816 G3 box; other site 1197719009817 Switch II region; other site 1197719009818 G4 box; other site 1197719009819 G5 box; other site 1197719009820 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1197719009821 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1197719009822 Antibiotic Binding Site [chemical binding]; other site 1197719009823 elongation factor G; Reviewed; Region: PRK00007 1197719009824 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1197719009825 G1 box; other site 1197719009826 putative GEF interaction site [polypeptide binding]; other site 1197719009827 GTP/Mg2+ binding site [chemical binding]; other site 1197719009828 Switch I region; other site 1197719009829 G2 box; other site 1197719009830 G3 box; other site 1197719009831 Switch II region; other site 1197719009832 G4 box; other site 1197719009833 G5 box; other site 1197719009834 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1197719009835 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1197719009836 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1197719009837 30S ribosomal protein S7; Validated; Region: PRK05302 1197719009838 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1197719009839 S17 interaction site [polypeptide binding]; other site 1197719009840 S8 interaction site; other site 1197719009841 16S rRNA interaction site [nucleotide binding]; other site 1197719009842 streptomycin interaction site [chemical binding]; other site 1197719009843 23S rRNA interaction site [nucleotide binding]; other site 1197719009844 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1197719009845 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1197719009846 sulfur relay protein TusC; Validated; Region: PRK00211 1197719009847 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1197719009848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1197719009849 YheO-like PAS domain; Region: PAS_6; pfam08348 1197719009850 HTH domain; Region: HTH_22; pfam13309 1197719009851 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1197719009852 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1197719009853 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1197719009854 phi X174 lysis protein; Provisional; Region: PRK02793 1197719009855 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1197719009856 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1197719009857 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1197719009858 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1197719009859 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1197719009860 TrkA-N domain; Region: TrkA_N; pfam02254 1197719009861 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1197719009862 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1197719009863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719009864 Walker A/P-loop; other site 1197719009865 ATP binding site [chemical binding]; other site 1197719009866 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719009867 ABC transporter signature motif; other site 1197719009868 Walker B; other site 1197719009869 D-loop; other site 1197719009870 ABC transporter; Region: ABC_tran_2; pfam12848 1197719009871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719009872 putative monooxygenase; Provisional; Region: PRK11118 1197719009873 putative hydrolase; Provisional; Region: PRK10985 1197719009874 hypothetical protein; Provisional; Region: PRK04966 1197719009875 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1197719009876 active site 1197719009877 OsmC-like protein; Region: OsmC; cl00767 1197719009878 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1197719009879 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1197719009880 ligand binding site [chemical binding]; other site 1197719009881 flexible hinge region; other site 1197719009882 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1197719009883 putative switch regulator; other site 1197719009884 non-specific DNA interactions [nucleotide binding]; other site 1197719009885 DNA binding site [nucleotide binding] 1197719009886 sequence specific DNA binding site [nucleotide binding]; other site 1197719009887 putative cAMP binding site [chemical binding]; other site 1197719009888 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1197719009889 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1197719009890 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1197719009891 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1197719009892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1197719009893 inhibitor-cofactor binding pocket; inhibition site 1197719009894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719009895 catalytic residue [active] 1197719009896 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1197719009897 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1197719009898 glutamine binding [chemical binding]; other site 1197719009899 catalytic triad [active] 1197719009900 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1197719009901 cell filamentation protein Fic; Provisional; Region: PRK10347 1197719009902 hypothetical protein; Provisional; Region: PRK10204 1197719009903 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1197719009904 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1197719009905 substrate binding site [chemical binding]; other site 1197719009906 putative transporter; Provisional; Region: PRK03699 1197719009907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719009908 putative substrate translocation pore; other site 1197719009909 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1197719009910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719009911 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1197719009912 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1197719009913 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1197719009914 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1197719009915 nitrite transporter NirC; Provisional; Region: PRK11562 1197719009916 siroheme synthase; Provisional; Region: cysG; PRK10637 1197719009917 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1197719009918 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1197719009919 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1197719009920 active site 1197719009921 SAM binding site [chemical binding]; other site 1197719009922 homodimer interface [polypeptide binding]; other site 1197719009923 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1197719009924 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1197719009925 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1197719009926 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1197719009927 active site 1197719009928 HIGH motif; other site 1197719009929 dimer interface [polypeptide binding]; other site 1197719009930 KMSKS motif; other site 1197719009931 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1197719009932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719009933 motif II; other site 1197719009934 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1197719009935 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1197719009936 substrate binding site [chemical binding]; other site 1197719009937 hexamer interface [polypeptide binding]; other site 1197719009938 metal binding site [ion binding]; metal-binding site 1197719009939 DNA adenine methylase; Provisional; Region: PRK10904 1197719009940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1197719009941 cell division protein DamX; Validated; Region: PRK10905 1197719009942 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1197719009943 active site 1197719009944 dimer interface [polypeptide binding]; other site 1197719009945 metal binding site [ion binding]; metal-binding site 1197719009946 shikimate kinase; Reviewed; Region: aroK; PRK00131 1197719009947 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1197719009948 ADP binding site [chemical binding]; other site 1197719009949 magnesium binding site [ion binding]; other site 1197719009950 putative shikimate binding site; other site 1197719009951 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1197719009952 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1197719009953 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1197719009954 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1197719009955 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1197719009956 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1197719009957 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1197719009958 Transglycosylase; Region: Transgly; pfam00912 1197719009959 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1197719009960 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1197719009961 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1197719009962 ADP-ribose binding site [chemical binding]; other site 1197719009963 dimer interface [polypeptide binding]; other site 1197719009964 active site 1197719009965 nudix motif; other site 1197719009966 metal binding site [ion binding]; metal-binding site 1197719009967 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1197719009968 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1197719009969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719009970 motif II; other site 1197719009971 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719009972 RNA binding surface [nucleotide binding]; other site 1197719009973 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1197719009974 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1197719009975 dimerization interface [polypeptide binding]; other site 1197719009976 domain crossover interface; other site 1197719009977 redox-dependent activation switch; other site 1197719009978 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1197719009979 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1197719009980 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1197719009981 active site 1197719009982 substrate-binding site [chemical binding]; other site 1197719009983 metal-binding site [ion binding] 1197719009984 ATP binding site [chemical binding]; other site 1197719009985 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1197719009986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719009987 dimerization interface [polypeptide binding]; other site 1197719009988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719009989 dimer interface [polypeptide binding]; other site 1197719009990 phosphorylation site [posttranslational modification] 1197719009991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719009992 ATP binding site [chemical binding]; other site 1197719009993 G-X-G motif; other site 1197719009994 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1197719009995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719009996 active site 1197719009997 phosphorylation site [posttranslational modification] 1197719009998 intermolecular recognition site; other site 1197719009999 dimerization interface [polypeptide binding]; other site 1197719010000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719010001 DNA binding site [nucleotide binding] 1197719010002 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1197719010003 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1197719010004 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1197719010005 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1197719010006 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1197719010007 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1197719010008 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1197719010009 RNA binding site [nucleotide binding]; other site 1197719010010 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1197719010011 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1197719010012 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1197719010013 G1 box; other site 1197719010014 GTP/Mg2+ binding site [chemical binding]; other site 1197719010015 Switch I region; other site 1197719010016 G2 box; other site 1197719010017 G3 box; other site 1197719010018 Switch II region; other site 1197719010019 G4 box; other site 1197719010020 G5 box; other site 1197719010021 Nucleoside recognition; Region: Gate; pfam07670 1197719010022 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1197719010023 Nucleoside recognition; Region: Gate; pfam07670 1197719010024 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1197719010025 hypothetical protein; Provisional; Region: PRK09956 1197719010026 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719010027 carboxylesterase BioH; Provisional; Region: PRK10349 1197719010028 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1197719010029 DNA utilization protein GntX; Provisional; Region: PRK11595 1197719010030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719010031 active site 1197719010032 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1197719010033 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1197719010034 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1197719010035 high-affinity gluconate transporter; Provisional; Region: PRK14984 1197719010036 gluconate transporter; Region: gntP; TIGR00791 1197719010037 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1197719010038 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1197719010039 maltodextrin phosphorylase; Provisional; Region: PRK14985 1197719010040 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1197719010041 active site pocket [active] 1197719010042 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1197719010043 transcriptional regulator MalT; Provisional; Region: PRK04841 1197719010044 AAA ATPase domain; Region: AAA_16; pfam13191 1197719010045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719010046 DNA binding residues [nucleotide binding] 1197719010047 dimerization interface [polypeptide binding]; other site 1197719010048 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1197719010049 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1197719010050 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719010051 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1197719010052 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1197719010053 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1197719010054 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1197719010055 active site residue [active] 1197719010056 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1197719010057 glycogen phosphorylase; Provisional; Region: PRK14986 1197719010058 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1197719010059 homodimer interface [polypeptide binding]; other site 1197719010060 active site pocket [active] 1197719010061 glycogen synthase; Provisional; Region: glgA; PRK00654 1197719010062 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1197719010063 ADP-binding pocket [chemical binding]; other site 1197719010064 homodimer interface [polypeptide binding]; other site 1197719010065 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1197719010066 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1197719010067 ligand binding site; other site 1197719010068 oligomer interface; other site 1197719010069 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1197719010070 dimer interface [polypeptide binding]; other site 1197719010071 N-terminal domain interface [polypeptide binding]; other site 1197719010072 sulfate 1 binding site; other site 1197719010073 glycogen debranching enzyme; Provisional; Region: PRK03705 1197719010074 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1197719010075 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1197719010076 active site 1197719010077 catalytic site [active] 1197719010078 glycogen branching enzyme; Provisional; Region: PRK05402 1197719010079 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1197719010080 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1197719010081 active site 1197719010082 catalytic site [active] 1197719010083 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1197719010084 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1197719010085 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1197719010086 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1197719010087 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1197719010088 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1197719010089 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1197719010090 polyol permease family; Region: 2A0118; TIGR00897 1197719010091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010092 putative substrate translocation pore; other site 1197719010093 low affinity gluconate transporter; Provisional; Region: PRK10472 1197719010094 gluconate transporter; Region: gntP; TIGR00791 1197719010095 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1197719010096 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1197719010097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719010098 DNA binding site [nucleotide binding] 1197719010099 domain linker motif; other site 1197719010100 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1197719010101 putative ligand binding site [chemical binding]; other site 1197719010102 putative dimerization interface [polypeptide binding]; other site 1197719010103 Pirin-related protein [General function prediction only]; Region: COG1741 1197719010104 Pirin; Region: Pirin; pfam02678 1197719010105 putative oxidoreductase; Provisional; Region: PRK10206 1197719010106 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1197719010107 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1197719010108 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719010109 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1197719010110 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719010111 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1197719010112 substrate binding site [chemical binding]; other site 1197719010113 dimer interface [polypeptide binding]; other site 1197719010114 ATP binding site [chemical binding]; other site 1197719010115 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1197719010116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1197719010117 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1197719010118 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1197719010119 active site 1197719010120 substrate binding pocket [chemical binding]; other site 1197719010121 homodimer interaction site [polypeptide binding]; other site 1197719010122 Protein of unknown function (DUF796); Region: DUF796; cl01226 1197719010123 Protein of unknown function (DUF796); Region: DUF796; cl01226 1197719010124 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1197719010125 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1197719010126 hypothetical protein; Provisional; Region: PRK10350 1197719010127 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1197719010128 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1197719010129 putative active site [active] 1197719010130 catalytic site [active] 1197719010131 putative metal binding site [ion binding]; other site 1197719010132 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1197719010133 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1197719010134 Walker A/P-loop; other site 1197719010135 ATP binding site [chemical binding]; other site 1197719010136 Q-loop/lid; other site 1197719010137 ABC transporter signature motif; other site 1197719010138 Walker B; other site 1197719010139 D-loop; other site 1197719010140 H-loop/switch region; other site 1197719010141 TOBE domain; Region: TOBE_2; pfam08402 1197719010142 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1197719010143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719010144 dimer interface [polypeptide binding]; other site 1197719010145 conserved gate region; other site 1197719010146 putative PBP binding loops; other site 1197719010147 ABC-ATPase subunit interface; other site 1197719010148 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1197719010149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719010150 putative PBP binding loops; other site 1197719010151 dimer interface [polypeptide binding]; other site 1197719010152 ABC-ATPase subunit interface; other site 1197719010153 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1197719010154 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1197719010155 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1197719010156 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1197719010157 Walker A/P-loop; other site 1197719010158 ATP binding site [chemical binding]; other site 1197719010159 Q-loop/lid; other site 1197719010160 ABC transporter signature motif; other site 1197719010161 Walker B; other site 1197719010162 D-loop; other site 1197719010163 H-loop/switch region; other site 1197719010164 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1197719010165 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1197719010166 Walker A/P-loop; other site 1197719010167 ATP binding site [chemical binding]; other site 1197719010168 Q-loop/lid; other site 1197719010169 ABC transporter signature motif; other site 1197719010170 Walker B; other site 1197719010171 D-loop; other site 1197719010172 H-loop/switch region; other site 1197719010173 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1197719010174 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1197719010175 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1197719010176 TM-ABC transporter signature motif; other site 1197719010177 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1197719010178 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1197719010179 TM-ABC transporter signature motif; other site 1197719010180 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1197719010181 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1197719010182 dimerization interface [polypeptide binding]; other site 1197719010183 ligand binding site [chemical binding]; other site 1197719010184 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1197719010185 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1197719010186 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1197719010187 dimerization interface [polypeptide binding]; other site 1197719010188 ligand binding site [chemical binding]; other site 1197719010189 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1197719010190 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1197719010191 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1197719010192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1197719010193 inhibitor-cofactor binding pocket; inhibition site 1197719010194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719010195 catalytic residue [active] 1197719010196 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1197719010197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719010198 DNA-binding site [nucleotide binding]; DNA binding site 1197719010199 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719010200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719010201 homodimer interface [polypeptide binding]; other site 1197719010202 catalytic residue [active] 1197719010203 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1197719010204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1197719010205 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1197719010206 DNA binding residues [nucleotide binding] 1197719010207 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1197719010208 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1197719010209 cell division protein FtsE; Provisional; Region: PRK10908 1197719010210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719010211 Walker A/P-loop; other site 1197719010212 ATP binding site [chemical binding]; other site 1197719010213 Q-loop/lid; other site 1197719010214 ABC transporter signature motif; other site 1197719010215 Walker B; other site 1197719010216 D-loop; other site 1197719010217 H-loop/switch region; other site 1197719010218 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1197719010219 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1197719010220 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1197719010221 P loop; other site 1197719010222 GTP binding site [chemical binding]; other site 1197719010223 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1197719010224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719010225 S-adenosylmethionine binding site [chemical binding]; other site 1197719010226 hypothetical protein; Provisional; Region: PRK10910 1197719010227 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1197719010228 Predicted membrane protein [Function unknown]; Region: COG3714 1197719010229 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1197719010230 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1197719010231 metal-binding site [ion binding] 1197719010232 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1197719010233 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1197719010234 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1197719010235 dimer interface [polypeptide binding]; other site 1197719010236 ligand binding site [chemical binding]; other site 1197719010237 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719010238 dimerization interface [polypeptide binding]; other site 1197719010239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719010240 dimer interface [polypeptide binding]; other site 1197719010241 putative CheW interface [polypeptide binding]; other site 1197719010242 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1197719010243 CPxP motif; other site 1197719010244 hypothetical protein; Provisional; Region: PRK11212 1197719010245 hypothetical protein; Provisional; Region: PRK11615 1197719010246 major facilitator superfamily transporter; Provisional; Region: PRK05122 1197719010247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010248 putative substrate translocation pore; other site 1197719010249 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1197719010250 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1197719010251 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1197719010252 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1197719010253 nickel responsive regulator; Provisional; Region: PRK02967 1197719010254 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1197719010255 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1197719010256 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1197719010257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1197719010258 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1197719010259 Walker A/P-loop; other site 1197719010260 ATP binding site [chemical binding]; other site 1197719010261 Q-loop/lid; other site 1197719010262 ABC transporter signature motif; other site 1197719010263 Walker B; other site 1197719010264 D-loop; other site 1197719010265 H-loop/switch region; other site 1197719010266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1197719010267 Walker A/P-loop; other site 1197719010268 ATP binding site [chemical binding]; other site 1197719010269 Q-loop/lid; other site 1197719010270 ABC transporter signature motif; other site 1197719010271 Walker B; other site 1197719010272 D-loop; other site 1197719010273 H-loop/switch region; other site 1197719010274 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1197719010275 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1197719010276 HlyD family secretion protein; Region: HlyD; pfam00529 1197719010277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719010278 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719010279 Predicted flavoproteins [General function prediction only]; Region: COG2081 1197719010280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719010281 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1197719010282 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1197719010283 universal stress protein UspB; Provisional; Region: PRK04960 1197719010284 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1197719010285 Ligand Binding Site [chemical binding]; other site 1197719010286 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1197719010287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010288 putative substrate translocation pore; other site 1197719010289 POT family; Region: PTR2; pfam00854 1197719010290 Predicted transcriptional regulator [Transcription]; Region: COG1959 1197719010291 Transcriptional regulator; Region: Rrf2; pfam02082 1197719010292 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1197719010293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719010294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719010295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719010296 S-adenosylmethionine binding site [chemical binding]; other site 1197719010297 oligopeptidase A; Provisional; Region: PRK10911 1197719010298 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1197719010299 active site 1197719010300 Zn binding site [ion binding]; other site 1197719010301 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1197719010302 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1197719010303 active site 1197719010304 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1197719010305 glutathione reductase; Validated; Region: PRK06116 1197719010306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1197719010307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719010308 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1197719010309 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1197719010310 active site 1197719010311 homodimer interface [polypeptide binding]; other site 1197719010312 homotetramer interface [polypeptide binding]; other site 1197719010313 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1197719010314 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1197719010315 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1197719010316 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719010317 substrate binding site [chemical binding]; other site 1197719010318 ATP binding site [chemical binding]; other site 1197719010319 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1197719010320 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1197719010321 putative active site [active] 1197719010322 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1197719010323 dimer interface [polypeptide binding]; other site 1197719010324 active site 1197719010325 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1197719010326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719010327 DNA-binding site [nucleotide binding]; DNA binding site 1197719010328 UTRA domain; Region: UTRA; pfam07702 1197719010329 trehalase; Provisional; Region: treF; PRK13270 1197719010330 Trehalase; Region: Trehalase; pfam01204 1197719010331 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 1197719010332 catalytic residue [active] 1197719010333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1197719010334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719010335 DNA binding residues [nucleotide binding] 1197719010336 dimerization interface [polypeptide binding]; other site 1197719010337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719010338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719010339 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1197719010340 putative effector binding pocket; other site 1197719010341 putative dimerization interface [polypeptide binding]; other site 1197719010342 inner membrane protein YhjD; Region: TIGR00766 1197719010343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010344 metabolite-proton symporter; Region: 2A0106; TIGR00883 1197719010345 putative substrate translocation pore; other site 1197719010346 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1197719010347 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1197719010348 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719010349 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719010350 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1197719010351 substrate binding site [chemical binding]; other site 1197719010352 ATP binding site [chemical binding]; other site 1197719010353 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1197719010354 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1197719010355 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1197719010356 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1197719010357 putative diguanylate cyclase; Provisional; Region: PRK13561 1197719010358 HAMP domain; Region: HAMP; pfam00672 1197719010359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719010360 metal binding site [ion binding]; metal-binding site 1197719010361 active site 1197719010362 I-site; other site 1197719010363 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719010364 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1197719010365 TPR repeat; Region: TPR_11; pfam13414 1197719010366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719010367 TPR motif; other site 1197719010368 binding surface 1197719010369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719010370 binding surface 1197719010371 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1197719010372 TPR motif; other site 1197719010373 Tetratricopeptide repeat; Region: TPR_15; pfam13429 1197719010374 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1197719010375 cellulose synthase regulator protein; Provisional; Region: PRK11114 1197719010376 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1197719010377 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1197719010378 DXD motif; other site 1197719010379 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1197719010380 PilZ domain; Region: PilZ; pfam07238 1197719010381 cell division protein; Provisional; Region: PRK10037 1197719010382 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1197719010383 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1197719010384 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1197719010385 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1197719010386 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1197719010387 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 1197719010388 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1197719010389 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1197719010390 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1197719010391 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719010392 Walker A/P-loop; other site 1197719010393 ATP binding site [chemical binding]; other site 1197719010394 Q-loop/lid; other site 1197719010395 ABC transporter signature motif; other site 1197719010396 Walker B; other site 1197719010397 D-loop; other site 1197719010398 H-loop/switch region; other site 1197719010399 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1197719010400 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1197719010401 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1197719010402 Walker A/P-loop; other site 1197719010403 ATP binding site [chemical binding]; other site 1197719010404 Q-loop/lid; other site 1197719010405 ABC transporter signature motif; other site 1197719010406 Walker B; other site 1197719010407 D-loop; other site 1197719010408 H-loop/switch region; other site 1197719010409 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1197719010410 dipeptide transporter; Provisional; Region: PRK10913 1197719010411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719010412 dimer interface [polypeptide binding]; other site 1197719010413 conserved gate region; other site 1197719010414 putative PBP binding loops; other site 1197719010415 ABC-ATPase subunit interface; other site 1197719010416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1197719010417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719010418 dimer interface [polypeptide binding]; other site 1197719010419 conserved gate region; other site 1197719010420 putative PBP binding loops; other site 1197719010421 ABC-ATPase subunit interface; other site 1197719010422 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1197719010423 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1197719010424 peptide binding site [polypeptide binding]; other site 1197719010425 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1197719010426 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1197719010427 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1197719010428 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719010429 DNA binding site [nucleotide binding] 1197719010430 domain linker motif; other site 1197719010431 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 1197719010432 putative dimerization interface [polypeptide binding]; other site 1197719010433 putative ligand binding site [chemical binding]; other site 1197719010434 phosphoethanolamine transferase; Provisional; Region: PRK11560 1197719010435 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1197719010436 Sulfatase; Region: Sulfatase; pfam00884 1197719010437 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 1197719010438 Fimbrial protein; Region: Fimbrial; cl01416 1197719010439 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 1197719010440 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719010441 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719010442 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719010443 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1197719010444 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719010445 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719010446 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 1197719010447 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1197719010448 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1197719010449 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1197719010450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719010451 Coenzyme A binding pocket [chemical binding]; other site 1197719010452 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1197719010453 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1197719010454 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1197719010455 molybdopterin cofactor binding site [chemical binding]; other site 1197719010456 substrate binding site [chemical binding]; other site 1197719010457 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1197719010458 molybdopterin cofactor binding site; other site 1197719010459 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1197719010460 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1197719010461 ligand binding site [chemical binding]; other site 1197719010462 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1197719010463 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1197719010464 dimerization interface [polypeptide binding]; other site 1197719010465 ligand binding site [chemical binding]; other site 1197719010466 NADP binding site [chemical binding]; other site 1197719010467 catalytic site [active] 1197719010468 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1197719010469 Predicted transcriptional regulator [Transcription]; Region: COG2944 1197719010470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719010471 salt bridge; other site 1197719010472 non-specific DNA binding site [nucleotide binding]; other site 1197719010473 sequence-specific DNA binding site [nucleotide binding]; other site 1197719010474 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1197719010475 DNA-binding site [nucleotide binding]; DNA binding site 1197719010476 RNA-binding motif; other site 1197719010477 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1197719010478 DALR anticodon binding domain; Region: DALR_1; pfam05746 1197719010479 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1197719010480 dimer interface [polypeptide binding]; other site 1197719010481 motif 1; other site 1197719010482 active site 1197719010483 motif 2; other site 1197719010484 motif 3; other site 1197719010485 YsaB-like lipoprotein; Region: YsaB; pfam13983 1197719010486 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1197719010487 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1197719010488 Predicted membrane protein [Function unknown]; Region: COG4682 1197719010489 yiaA/B two helix domain; Region: YiaAB; pfam05360 1197719010490 yiaA/B two helix domain; Region: YiaAB; cl01759 1197719010491 xylulokinase; Provisional; Region: PRK15027 1197719010492 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1197719010493 N- and C-terminal domain interface [polypeptide binding]; other site 1197719010494 active site 1197719010495 MgATP binding site [chemical binding]; other site 1197719010496 catalytic site [active] 1197719010497 metal binding site [ion binding]; metal-binding site 1197719010498 xylulose binding site [chemical binding]; other site 1197719010499 homodimer interface [polypeptide binding]; other site 1197719010500 xylose isomerase; Provisional; Region: PRK05474 1197719010501 xylose isomerase; Region: xylose_isom_A; TIGR02630 1197719010502 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1197719010503 putative dimerization interface [polypeptide binding]; other site 1197719010504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1197719010505 putative ligand binding site [chemical binding]; other site 1197719010506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719010507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1197719010508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719010509 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1197719010510 hypothetical protein; Provisional; Region: PRK10356 1197719010511 alpha-amylase; Reviewed; Region: malS; PRK09505 1197719010512 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1197719010513 active site 1197719010514 catalytic site [active] 1197719010515 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1197719010516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719010517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719010518 homodimer interface [polypeptide binding]; other site 1197719010519 catalytic residue [active] 1197719010520 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1197719010521 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1197719010522 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1197719010523 NAD(P) binding site [chemical binding]; other site 1197719010524 catalytic residues [active] 1197719010525 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1197719010526 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1197719010527 nucleotide binding site [chemical binding]; other site 1197719010528 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1197719010529 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1197719010530 dimer interface [polypeptide binding]; other site 1197719010531 active site 1197719010532 metal binding site [ion binding]; metal-binding site 1197719010533 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1197719010534 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1197719010535 G1 box; other site 1197719010536 putative GEF interaction site [polypeptide binding]; other site 1197719010537 GTP/Mg2+ binding site [chemical binding]; other site 1197719010538 Switch I region; other site 1197719010539 G2 box; other site 1197719010540 G3 box; other site 1197719010541 Switch II region; other site 1197719010542 G4 box; other site 1197719010543 G5 box; other site 1197719010544 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1197719010545 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1197719010546 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1197719010547 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1197719010548 selenocysteine synthase; Provisional; Region: PRK04311 1197719010549 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1197719010550 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1197719010551 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1197719010552 catalytic residue [active] 1197719010553 putative glutathione S-transferase; Provisional; Region: PRK10357 1197719010554 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1197719010555 putative C-terminal domain interface [polypeptide binding]; other site 1197719010556 putative GSH binding site (G-site) [chemical binding]; other site 1197719010557 putative dimer interface [polypeptide binding]; other site 1197719010558 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1197719010559 dimer interface [polypeptide binding]; other site 1197719010560 N-terminal domain interface [polypeptide binding]; other site 1197719010561 putative substrate binding pocket (H-site) [chemical binding]; other site 1197719010562 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1197719010563 Domain of unknown function (DUF202); Region: DUF202; cl09954 1197719010564 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1197719010565 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1197719010566 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1197719010567 putative active site [active] 1197719010568 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1197719010569 active site 1197719010570 catalytic residues [active] 1197719010571 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1197719010572 Sulfatase; Region: Sulfatase; cl17466 1197719010573 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1197719010574 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1197719010575 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1197719010576 active site turn [active] 1197719010577 phosphorylation site [posttranslational modification] 1197719010578 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1197719010579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719010580 FeS/SAM binding site; other site 1197719010581 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1197719010582 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1197719010583 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1197719010584 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1197719010585 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1197719010586 active site 1197719010587 P-loop; other site 1197719010588 phosphorylation site [posttranslational modification] 1197719010589 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719010590 active site 1197719010591 phosphorylation site [posttranslational modification] 1197719010592 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1197719010593 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1197719010594 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1197719010595 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1197719010596 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1197719010597 hypothetical protein; Provisional; Region: PRK11020 1197719010598 L-lactate permease; Provisional; Region: PRK10420 1197719010599 glycolate transporter; Provisional; Region: PRK09695 1197719010600 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1197719010601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719010602 DNA-binding site [nucleotide binding]; DNA binding site 1197719010603 FCD domain; Region: FCD; pfam07729 1197719010604 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1197719010605 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1197719010606 active site 1197719010607 substrate binding site [chemical binding]; other site 1197719010608 FMN binding site [chemical binding]; other site 1197719010609 putative catalytic residues [active] 1197719010610 putative rRNA methylase; Provisional; Region: PRK10358 1197719010611 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1197719010612 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1197719010613 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1197719010614 trimer interface [polypeptide binding]; other site 1197719010615 active site 1197719010616 substrate binding site [chemical binding]; other site 1197719010617 CoA binding site [chemical binding]; other site 1197719010618 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1197719010619 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1197719010620 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1197719010621 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1197719010622 SecA binding site; other site 1197719010623 Preprotein binding site; other site 1197719010624 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1197719010625 GSH binding site [chemical binding]; other site 1197719010626 catalytic residues [active] 1197719010627 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1197719010628 active site residue [active] 1197719010629 phosphoglyceromutase; Provisional; Region: PRK05434 1197719010630 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1197719010631 AmiB activator; Provisional; Region: PRK11637 1197719010632 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1197719010633 Peptidase family M23; Region: Peptidase_M23; pfam01551 1197719010634 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1197719010635 NodB motif; other site 1197719010636 putative active site [active] 1197719010637 putative catalytic site [active] 1197719010638 Zn binding site [ion binding]; other site 1197719010639 putative glycosyl transferase; Provisional; Region: PRK10073 1197719010640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1197719010641 active site 1197719010642 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1197719010643 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1197719010644 NAD(P) binding site [chemical binding]; other site 1197719010645 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1197719010646 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1197719010647 substrate-cofactor binding pocket; other site 1197719010648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719010649 catalytic residue [active] 1197719010650 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1197719010651 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1197719010652 NADP binding site [chemical binding]; other site 1197719010653 homopentamer interface [polypeptide binding]; other site 1197719010654 substrate binding site [chemical binding]; other site 1197719010655 active site 1197719010656 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1197719010657 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1197719010658 putative active site [active] 1197719010659 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1197719010660 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1197719010661 putative active site [active] 1197719010662 O-antigen ligase RfaL; Provisional; Region: PRK15487 1197719010663 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1197719010664 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1197719010665 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1197719010666 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1197719010667 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526 1197719010668 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1197719010669 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1197719010670 Ligand binding site; other site 1197719010671 metal-binding site 1197719010672 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1197719010673 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1197719010674 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1197719010675 Ligand binding site; other site 1197719010676 metal-binding site 1197719010677 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1197719010678 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1197719010679 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1197719010680 putative ADP-binding pocket [chemical binding]; other site 1197719010681 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 1197719010682 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1197719010683 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1197719010684 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1197719010685 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1197719010686 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1197719010687 putative active site [active] 1197719010688 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1197719010689 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1197719010690 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1197719010691 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1197719010692 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1197719010693 active site 1197719010694 (T/H)XGH motif; other site 1197719010695 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1197719010696 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1197719010697 DNA binding site [nucleotide binding] 1197719010698 catalytic residue [active] 1197719010699 H2TH interface [polypeptide binding]; other site 1197719010700 putative catalytic residues [active] 1197719010701 turnover-facilitating residue; other site 1197719010702 intercalation triad [nucleotide binding]; other site 1197719010703 8OG recognition residue [nucleotide binding]; other site 1197719010704 putative reading head residues; other site 1197719010705 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1197719010706 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1197719010707 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1197719010708 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1197719010709 hypothetical protein; Reviewed; Region: PRK00024 1197719010710 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1197719010711 MPN+ (JAMM) motif; other site 1197719010712 Zinc-binding site [ion binding]; other site 1197719010713 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1197719010714 Flavoprotein; Region: Flavoprotein; pfam02441 1197719010715 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1197719010716 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1197719010717 trimer interface [polypeptide binding]; other site 1197719010718 active site 1197719010719 division inhibitor protein; Provisional; Region: slmA; PRK09480 1197719010720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719010721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1197719010722 active site 1197719010723 ribonuclease PH; Reviewed; Region: rph; PRK00173 1197719010724 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1197719010725 hexamer interface [polypeptide binding]; other site 1197719010726 active site 1197719010727 hypothetical protein; Provisional; Region: PRK11820 1197719010728 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1197719010729 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1197719010730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719010731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719010732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1197719010733 dimerization interface [polypeptide binding]; other site 1197719010734 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1197719010735 Predicted membrane protein [Function unknown]; Region: COG2860 1197719010736 UPF0126 domain; Region: UPF0126; pfam03458 1197719010737 UPF0126 domain; Region: UPF0126; pfam03458 1197719010738 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1197719010739 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1197719010740 nucleotide binding pocket [chemical binding]; other site 1197719010741 K-X-D-G motif; other site 1197719010742 catalytic site [active] 1197719010743 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1197719010744 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1197719010745 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1197719010746 catalytic site [active] 1197719010747 G-X2-G-X-G-K; other site 1197719010748 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1197719010749 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1197719010750 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1197719010751 Zn2+ binding site [ion binding]; other site 1197719010752 Mg2+ binding site [ion binding]; other site 1197719010753 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1197719010754 synthetase active site [active] 1197719010755 NTP binding site [chemical binding]; other site 1197719010756 metal binding site [ion binding]; metal-binding site 1197719010757 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1197719010758 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1197719010759 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1197719010760 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1197719010761 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1197719010762 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1197719010763 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1197719010764 generic binding surface II; other site 1197719010765 ssDNA binding site; other site 1197719010766 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719010767 ATP binding site [chemical binding]; other site 1197719010768 putative Mg++ binding site [ion binding]; other site 1197719010769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719010770 nucleotide binding region [chemical binding]; other site 1197719010771 ATP-binding site [chemical binding]; other site 1197719010772 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1197719010773 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1197719010774 AsmA family; Region: AsmA; pfam05170 1197719010775 putative alpha-glucosidase; Provisional; Region: PRK10658 1197719010776 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1197719010777 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1197719010778 active site 1197719010779 homotrimer interface [polypeptide binding]; other site 1197719010780 catalytic site [active] 1197719010781 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1197719010782 putative transporter; Provisional; Region: PRK11462 1197719010783 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1197719010784 Isochorismatase family; Region: Isochorismatase; pfam00857 1197719010785 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1197719010786 catalytic triad [active] 1197719010787 dimer interface [polypeptide binding]; other site 1197719010788 conserved cis-peptide bond; other site 1197719010789 magnesium-transporting ATPase; Provisional; Region: PRK15122 1197719010790 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1197719010791 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1197719010792 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1197719010793 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1197719010794 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1197719010795 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1197719010796 magnesium transport protein MgtC; Provisional; Region: PRK15385 1197719010797 MgtC family; Region: MgtC; pfam02308 1197719010798 EamA-like transporter family; Region: EamA; pfam00892 1197719010799 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1197719010800 EamA-like transporter family; Region: EamA; pfam00892 1197719010801 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719010802 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719010803 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 1197719010804 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1197719010805 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1197719010806 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1197719010807 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1197719010808 active site 1197719010809 phosphorylation site [posttranslational modification] 1197719010810 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1197719010811 active pocket/dimerization site; other site 1197719010812 active site 1197719010813 phosphorylation site [posttranslational modification] 1197719010814 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1197719010815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719010816 Walker A motif; other site 1197719010817 ATP binding site [chemical binding]; other site 1197719010818 Walker B motif; other site 1197719010819 arginine finger; other site 1197719010820 Transcriptional antiterminator [Transcription]; Region: COG3933 1197719010821 PRD domain; Region: PRD; pfam00874 1197719010822 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1197719010823 beta-galactosidase; Region: BGL; TIGR03356 1197719010824 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1197719010825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010826 putative substrate translocation pore; other site 1197719010827 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1197719010828 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719010829 RHS protein; Region: RHS; pfam03527 1197719010830 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719010831 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719010832 RHS protein; Region: RHS; pfam03527 1197719010833 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719010834 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719010835 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719010836 PAAR motif; Region: PAAR_motif; cl15808 1197719010837 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719010838 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719010839 RHS Repeat; Region: RHS_repeat; pfam05593 1197719010840 RHS Repeat; Region: RHS_repeat; pfam05593 1197719010841 RHS protein; Region: RHS; pfam03527 1197719010842 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719010843 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1197719010844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010845 putative substrate translocation pore; other site 1197719010846 regulatory protein UhpC; Provisional; Region: PRK11663 1197719010847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010848 putative substrate translocation pore; other site 1197719010849 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1197719010850 MASE1; Region: MASE1; pfam05231 1197719010851 Histidine kinase; Region: HisKA_3; pfam07730 1197719010852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719010853 ATP binding site [chemical binding]; other site 1197719010854 Mg2+ binding site [ion binding]; other site 1197719010855 G-X-G motif; other site 1197719010856 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1197719010857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719010858 active site 1197719010859 phosphorylation site [posttranslational modification] 1197719010860 intermolecular recognition site; other site 1197719010861 dimerization interface [polypeptide binding]; other site 1197719010862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719010863 DNA binding residues [nucleotide binding] 1197719010864 dimerization interface [polypeptide binding]; other site 1197719010865 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1197719010866 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1197719010867 putative valine binding site [chemical binding]; other site 1197719010868 dimer interface [polypeptide binding]; other site 1197719010869 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1197719010870 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1197719010871 PYR/PP interface [polypeptide binding]; other site 1197719010872 dimer interface [polypeptide binding]; other site 1197719010873 TPP binding site [chemical binding]; other site 1197719010874 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1197719010875 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1197719010876 TPP-binding site [chemical binding]; other site 1197719010877 dimer interface [polypeptide binding]; other site 1197719010878 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1197719010879 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1197719010880 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1197719010881 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1197719010882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719010883 putative substrate translocation pore; other site 1197719010884 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1197719010885 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1197719010886 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1197719010887 Predicted membrane protein [Function unknown]; Region: COG2149 1197719010888 putative transporter; Validated; Region: PRK03818 1197719010889 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1197719010890 TrkA-C domain; Region: TrkA_C; pfam02080 1197719010891 TrkA-C domain; Region: TrkA_C; pfam02080 1197719010892 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1197719010893 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1197719010894 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1197719010895 putative dimer interface [polypeptide binding]; other site 1197719010896 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1197719010897 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1197719010898 putative dimer interface [polypeptide binding]; other site 1197719010899 hypothetical protein; Provisional; Region: PRK11616 1197719010900 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1197719010901 putative oxidoreductase; Provisional; Region: PRK11445 1197719010902 hypothetical protein; Provisional; Region: PRK07236 1197719010903 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1197719010904 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1197719010905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1197719010906 binding surface 1197719010907 TPR motif; other site 1197719010908 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1197719010909 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1197719010910 catalytic residues [active] 1197719010911 central insert; other site 1197719010912 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1197719010913 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1197719010914 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1197719010915 heme exporter protein CcmC; Region: ccmC; TIGR01191 1197719010916 heme exporter protein CcmB; Region: ccmB; TIGR01190 1197719010917 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1197719010918 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1197719010919 Walker A/P-loop; other site 1197719010920 ATP binding site [chemical binding]; other site 1197719010921 Q-loop/lid; other site 1197719010922 ABC transporter signature motif; other site 1197719010923 Walker B; other site 1197719010924 D-loop; other site 1197719010925 H-loop/switch region; other site 1197719010926 Haem-binding domain; Region: Haem_bd; pfam14376 1197719010927 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1197719010928 chaperone protein TorD; Validated; Region: torD; PRK04976 1197719010929 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1197719010930 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1197719010931 molybdopterin cofactor binding site [chemical binding]; other site 1197719010932 substrate binding site [chemical binding]; other site 1197719010933 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1197719010934 molybdopterin cofactor binding site; other site 1197719010935 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1197719010936 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1197719010937 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1197719010938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719010939 active site 1197719010940 phosphorylation site [posttranslational modification] 1197719010941 intermolecular recognition site; other site 1197719010942 dimerization interface [polypeptide binding]; other site 1197719010943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719010944 DNA binding site [nucleotide binding] 1197719010945 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1197719010946 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1197719010947 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1197719010948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719010949 dimer interface [polypeptide binding]; other site 1197719010950 phosphorylation site [posttranslational modification] 1197719010951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719010952 ATP binding site [chemical binding]; other site 1197719010953 Mg2+ binding site [ion binding]; other site 1197719010954 G-X-G motif; other site 1197719010955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719010956 active site 1197719010957 phosphorylation site [posttranslational modification] 1197719010958 intermolecular recognition site; other site 1197719010959 dimerization interface [polypeptide binding]; other site 1197719010960 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1197719010961 putative binding surface; other site 1197719010962 active site 1197719010963 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 1197719010964 Surface antigen; Region: Bac_surface_Ag; pfam01103 1197719010965 sugar phosphate phosphatase; Provisional; Region: PRK10513 1197719010966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719010967 active site 1197719010968 motif I; other site 1197719010969 motif II; other site 1197719010970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719010971 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1197719010972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719010973 Mg2+ binding site [ion binding]; other site 1197719010974 G-X-G motif; other site 1197719010975 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1197719010976 anchoring element; other site 1197719010977 dimer interface [polypeptide binding]; other site 1197719010978 ATP binding site [chemical binding]; other site 1197719010979 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1197719010980 active site 1197719010981 putative metal-binding site [ion binding]; other site 1197719010982 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1197719010983 recF protein; Region: recf; TIGR00611 1197719010984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719010985 Walker A/P-loop; other site 1197719010986 ATP binding site [chemical binding]; other site 1197719010987 Q-loop/lid; other site 1197719010988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719010989 ABC transporter signature motif; other site 1197719010990 Walker B; other site 1197719010991 D-loop; other site 1197719010992 H-loop/switch region; other site 1197719010993 DNA polymerase III subunit beta; Validated; Region: PRK05643 1197719010994 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1197719010995 putative DNA binding surface [nucleotide binding]; other site 1197719010996 dimer interface [polypeptide binding]; other site 1197719010997 beta-clamp/clamp loader binding surface; other site 1197719010998 beta-clamp/translesion DNA polymerase binding surface; other site 1197719010999 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1197719011000 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1197719011001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719011002 Walker A motif; other site 1197719011003 ATP binding site [chemical binding]; other site 1197719011004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1197719011005 Walker B motif; other site 1197719011006 arginine finger; other site 1197719011007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1197719011008 DnaA box-binding interface [nucleotide binding]; other site 1197719011009 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1197719011010 Ribonuclease P; Region: Ribonuclease_P; cl00457 1197719011011 membrane protein insertase; Provisional; Region: PRK01318 1197719011012 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1197719011013 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1197719011014 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1197719011015 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1197719011016 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1197719011017 G1 box; other site 1197719011018 GTP/Mg2+ binding site [chemical binding]; other site 1197719011019 Switch I region; other site 1197719011020 G2 box; other site 1197719011021 Switch II region; other site 1197719011022 G3 box; other site 1197719011023 G4 box; other site 1197719011024 G5 box; other site 1197719011025 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1197719011026 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1197719011027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719011028 putative substrate translocation pore; other site 1197719011029 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1197719011030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719011031 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1197719011032 substrate binding pocket [chemical binding]; other site 1197719011033 dimerization interface [polypeptide binding]; other site 1197719011034 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1197719011035 Predicted flavoprotein [General function prediction only]; Region: COG0431 1197719011036 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1197719011037 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1197719011038 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1197719011039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1197719011040 active site 1197719011041 motif I; other site 1197719011042 motif II; other site 1197719011043 transcriptional regulator PhoU; Provisional; Region: PRK11115 1197719011044 PhoU domain; Region: PhoU; pfam01895 1197719011045 PhoU domain; Region: PhoU; pfam01895 1197719011046 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1197719011047 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1197719011048 Walker A/P-loop; other site 1197719011049 ATP binding site [chemical binding]; other site 1197719011050 Q-loop/lid; other site 1197719011051 ABC transporter signature motif; other site 1197719011052 Walker B; other site 1197719011053 D-loop; other site 1197719011054 H-loop/switch region; other site 1197719011055 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1197719011056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719011057 dimer interface [polypeptide binding]; other site 1197719011058 conserved gate region; other site 1197719011059 putative PBP binding loops; other site 1197719011060 ABC-ATPase subunit interface; other site 1197719011061 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1197719011062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719011063 dimer interface [polypeptide binding]; other site 1197719011064 conserved gate region; other site 1197719011065 putative PBP binding loops; other site 1197719011066 ABC-ATPase subunit interface; other site 1197719011067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719011068 Fimbrial protein; Region: Fimbrial; cl01416 1197719011069 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1197719011070 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719011071 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719011072 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719011073 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 1197719011074 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719011075 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719011076 Fimbrial protein; Region: Fimbrial; cl01416 1197719011077 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1197719011078 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1197719011079 glutaminase active site [active] 1197719011080 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1197719011081 dimer interface [polypeptide binding]; other site 1197719011082 active site 1197719011083 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1197719011084 dimer interface [polypeptide binding]; other site 1197719011085 active site 1197719011086 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1197719011087 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1197719011088 Substrate binding site; other site 1197719011089 Mg++ binding site; other site 1197719011090 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1197719011091 active site 1197719011092 substrate binding site [chemical binding]; other site 1197719011093 CoA binding site [chemical binding]; other site 1197719011094 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1197719011095 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1197719011096 gamma subunit interface [polypeptide binding]; other site 1197719011097 epsilon subunit interface [polypeptide binding]; other site 1197719011098 LBP interface [polypeptide binding]; other site 1197719011099 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1197719011100 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1197719011101 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1197719011102 alpha subunit interaction interface [polypeptide binding]; other site 1197719011103 Walker A motif; other site 1197719011104 ATP binding site [chemical binding]; other site 1197719011105 Walker B motif; other site 1197719011106 inhibitor binding site; inhibition site 1197719011107 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1197719011108 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1197719011109 core domain interface [polypeptide binding]; other site 1197719011110 delta subunit interface [polypeptide binding]; other site 1197719011111 epsilon subunit interface [polypeptide binding]; other site 1197719011112 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1197719011113 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1197719011114 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1197719011115 beta subunit interaction interface [polypeptide binding]; other site 1197719011116 Walker A motif; other site 1197719011117 ATP binding site [chemical binding]; other site 1197719011118 Walker B motif; other site 1197719011119 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1197719011120 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1197719011121 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1197719011122 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1197719011123 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1197719011124 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1197719011125 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1197719011126 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1197719011127 ATP synthase I chain; Region: ATP_synt_I; cl09170 1197719011128 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1197719011129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719011130 S-adenosylmethionine binding site [chemical binding]; other site 1197719011131 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1197719011132 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1197719011133 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1197719011134 FMN-binding protein MioC; Provisional; Region: PRK09004 1197719011135 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1197719011136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1197719011137 putative DNA binding site [nucleotide binding]; other site 1197719011138 putative Zn2+ binding site [ion binding]; other site 1197719011139 AsnC family; Region: AsnC_trans_reg; pfam01037 1197719011140 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1197719011141 dimer interface [polypeptide binding]; other site 1197719011142 active site 1197719011143 hypothetical protein; Provisional; Region: yieM; PRK10997 1197719011144 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1197719011145 metal ion-dependent adhesion site (MIDAS); other site 1197719011146 regulatory ATPase RavA; Provisional; Region: PRK13531 1197719011147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719011148 Walker A motif; other site 1197719011149 ATP binding site [chemical binding]; other site 1197719011150 Walker B motif; other site 1197719011151 arginine finger; other site 1197719011152 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1197719011153 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1197719011154 potassium uptake protein; Region: kup; TIGR00794 1197719011155 D-ribose pyranase; Provisional; Region: PRK11797 1197719011156 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1197719011157 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1197719011158 Walker A/P-loop; other site 1197719011159 ATP binding site [chemical binding]; other site 1197719011160 Q-loop/lid; other site 1197719011161 ABC transporter signature motif; other site 1197719011162 Walker B; other site 1197719011163 D-loop; other site 1197719011164 H-loop/switch region; other site 1197719011165 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1197719011166 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1197719011167 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1197719011168 TM-ABC transporter signature motif; other site 1197719011169 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1197719011170 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1197719011171 ligand binding site [chemical binding]; other site 1197719011172 dimerization interface [polypeptide binding]; other site 1197719011173 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719011174 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1197719011175 substrate binding site [chemical binding]; other site 1197719011176 dimer interface [polypeptide binding]; other site 1197719011177 ATP binding site [chemical binding]; other site 1197719011178 transcriptional repressor RbsR; Provisional; Region: PRK10423 1197719011179 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719011180 DNA binding site [nucleotide binding] 1197719011181 domain linker motif; other site 1197719011182 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1197719011183 dimerization interface [polypeptide binding]; other site 1197719011184 ligand binding site [chemical binding]; other site 1197719011185 putative transporter; Provisional; Region: PRK10504 1197719011186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719011187 putative substrate translocation pore; other site 1197719011188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719011189 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1197719011190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719011191 DNA-binding site [nucleotide binding]; DNA binding site 1197719011192 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1197719011193 transcriptional regulator HdfR; Provisional; Region: PRK03601 1197719011194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719011195 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1197719011196 dimerization interface [polypeptide binding]; other site 1197719011197 hypothetical protein; Provisional; Region: PRK11027 1197719011198 putative ATP-dependent protease; Provisional; Region: PRK09862 1197719011199 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1197719011200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719011201 Walker A motif; other site 1197719011202 ATP binding site [chemical binding]; other site 1197719011203 Walker B motif; other site 1197719011204 arginine finger; other site 1197719011205 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1197719011206 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1197719011207 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1197719011208 PYR/PP interface [polypeptide binding]; other site 1197719011209 dimer interface [polypeptide binding]; other site 1197719011210 TPP binding site [chemical binding]; other site 1197719011211 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1197719011212 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1197719011213 TPP-binding site [chemical binding]; other site 1197719011214 dimer interface [polypeptide binding]; other site 1197719011215 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1197719011216 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1197719011217 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1197719011218 homodimer interface [polypeptide binding]; other site 1197719011219 substrate-cofactor binding pocket; other site 1197719011220 catalytic residue [active] 1197719011221 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1197719011222 threonine dehydratase; Reviewed; Region: PRK09224 1197719011223 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1197719011224 tetramer interface [polypeptide binding]; other site 1197719011225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719011226 catalytic residue [active] 1197719011227 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1197719011228 putative Ile/Val binding site [chemical binding]; other site 1197719011229 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1197719011230 putative Ile/Val binding site [chemical binding]; other site 1197719011231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719011232 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1197719011233 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1197719011234 putative dimerization interface [polypeptide binding]; other site 1197719011235 ketol-acid reductoisomerase; Validated; Region: PRK05225 1197719011236 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1197719011237 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1197719011238 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1197719011239 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1197719011240 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1197719011241 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1197719011242 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1197719011243 ligand binding site [chemical binding]; other site 1197719011244 flexible hinge region; other site 1197719011245 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1197719011246 uridine phosphorylase; Provisional; Region: PRK11178 1197719011247 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1197719011248 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1197719011249 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1197719011250 Part of AAA domain; Region: AAA_19; pfam13245 1197719011251 Family description; Region: UvrD_C_2; pfam13538 1197719011252 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1197719011253 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1197719011254 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1197719011255 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1197719011256 ATP binding site [chemical binding]; other site 1197719011257 Mg++ binding site [ion binding]; other site 1197719011258 motif III; other site 1197719011259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719011260 nucleotide binding region [chemical binding]; other site 1197719011261 ATP-binding site [chemical binding]; other site 1197719011262 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1197719011263 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1197719011264 catalytic residues [active] 1197719011265 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1197719011266 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1197719011267 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1197719011268 RNA binding site [nucleotide binding]; other site 1197719011269 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1197719011270 multimer interface [polypeptide binding]; other site 1197719011271 Walker A motif; other site 1197719011272 ATP binding site [chemical binding]; other site 1197719011273 Walker B motif; other site 1197719011274 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1197719011275 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1197719011276 Mg++ binding site [ion binding]; other site 1197719011277 putative catalytic motif [active] 1197719011278 substrate binding site [chemical binding]; other site 1197719011279 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1197719011280 Chain length determinant protein; Region: Wzz; pfam02706 1197719011281 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1197719011282 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1197719011283 homodimer interface [polypeptide binding]; other site 1197719011284 active site 1197719011285 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1197719011286 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1197719011287 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1197719011288 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1197719011289 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1197719011290 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1197719011291 NAD binding site [chemical binding]; other site 1197719011292 substrate binding site [chemical binding]; other site 1197719011293 homodimer interface [polypeptide binding]; other site 1197719011294 active site 1197719011295 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1197719011296 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1197719011297 substrate binding site; other site 1197719011298 tetramer interface; other site 1197719011299 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1197719011300 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1197719011301 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1197719011302 inhibitor-cofactor binding pocket; inhibition site 1197719011303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719011304 catalytic residue [active] 1197719011305 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1197719011306 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1197719011307 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1197719011308 putative common antigen polymerase; Provisional; Region: PRK02975 1197719011309 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1197719011310 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1197719011311 putative transport protein YifK; Provisional; Region: PRK10746 1197719011312 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1197719011313 HemY protein N-terminus; Region: HemY_N; pfam07219 1197719011314 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1197719011315 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1197719011316 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1197719011317 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1197719011318 active site 1197719011319 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1197719011320 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1197719011321 domain interfaces; other site 1197719011322 active site 1197719011323 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1197719011324 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1197719011325 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1197719011326 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1197719011327 putative iron binding site [ion binding]; other site 1197719011328 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1197719011329 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1197719011330 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1197719011331 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1197719011332 hypothetical protein; Provisional; Region: PRK10963 1197719011333 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1197719011334 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1197719011335 active site 1197719011336 Int/Topo IB signature motif; other site 1197719011337 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1197719011338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719011339 motif II; other site 1197719011340 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1197719011341 Part of AAA domain; Region: AAA_19; pfam13245 1197719011342 Family description; Region: UvrD_C_2; pfam13538 1197719011343 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1197719011344 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1197719011345 Cl binding site [ion binding]; other site 1197719011346 oligomer interface [polypeptide binding]; other site 1197719011347 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1197719011348 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1197719011349 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1197719011350 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1197719011351 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1197719011352 CoenzymeA binding site [chemical binding]; other site 1197719011353 subunit interaction site [polypeptide binding]; other site 1197719011354 PHB binding site; other site 1197719011355 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1197719011356 dimerization interface [polypeptide binding]; other site 1197719011357 substrate binding site [chemical binding]; other site 1197719011358 active site 1197719011359 calcium binding site [ion binding]; other site 1197719011360 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1197719011361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719011362 ATP binding site [chemical binding]; other site 1197719011363 putative Mg++ binding site [ion binding]; other site 1197719011364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1197719011365 nucleotide binding region [chemical binding]; other site 1197719011366 ATP-binding site [chemical binding]; other site 1197719011367 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1197719011368 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1197719011369 threonine efflux system; Provisional; Region: PRK10229 1197719011370 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1197719011371 lysophospholipase L2; Provisional; Region: PRK10749 1197719011372 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1197719011373 putative hydrolase; Provisional; Region: PRK10976 1197719011374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719011375 active site 1197719011376 motif I; other site 1197719011377 motif II; other site 1197719011378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719011379 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1197719011380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719011381 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1197719011382 putative dimerization interface [polypeptide binding]; other site 1197719011383 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1197719011384 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1197719011385 THF binding site; other site 1197719011386 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1197719011387 substrate binding site [chemical binding]; other site 1197719011388 THF binding site; other site 1197719011389 zinc-binding site [ion binding]; other site 1197719011390 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1197719011391 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1197719011392 uridine phosphorylase; Provisional; Region: PRK11178 1197719011393 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1197719011394 DNA recombination protein RmuC; Provisional; Region: PRK10361 1197719011395 RmuC family; Region: RmuC; pfam02646 1197719011396 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1197719011397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719011398 S-adenosylmethionine binding site [chemical binding]; other site 1197719011399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1197719011400 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1197719011401 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1197719011402 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1197719011403 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1197719011404 sec-independent translocase; Provisional; Region: PRK01770 1197719011405 sec-independent translocase; Provisional; Region: tatB; PRK00404 1197719011406 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1197719011407 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1197719011408 active site 1197719011409 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1197719011410 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1197719011411 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1197719011412 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1197719011413 FMN reductase; Validated; Region: fre; PRK08051 1197719011414 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1197719011415 FAD binding pocket [chemical binding]; other site 1197719011416 FAD binding motif [chemical binding]; other site 1197719011417 phosphate binding motif [ion binding]; other site 1197719011418 beta-alpha-beta structure motif; other site 1197719011419 NAD binding pocket [chemical binding]; other site 1197719011420 hypothetical protein; Reviewed; Region: PRK11901 1197719011421 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1197719011422 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1197719011423 dimer interface [polypeptide binding]; other site 1197719011424 active site 1197719011425 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1197719011426 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1197719011427 substrate binding site [chemical binding]; other site 1197719011428 oxyanion hole (OAH) forming residues; other site 1197719011429 trimer interface [polypeptide binding]; other site 1197719011430 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1197719011431 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1197719011432 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1197719011433 proline dipeptidase; Provisional; Region: PRK13607 1197719011434 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1197719011435 active site 1197719011436 hypothetical protein; Provisional; Region: PRK11568 1197719011437 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1197719011438 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1197719011439 potassium transporter; Provisional; Region: PRK10750 1197719011440 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1197719011441 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1197719011442 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1197719011443 Walker A motif; other site 1197719011444 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1197719011445 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1197719011446 GTP binding site; other site 1197719011447 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1197719011448 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1197719011449 serine/threonine protein kinase; Provisional; Region: PRK11768 1197719011450 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1197719011451 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1197719011452 catalytic residues [active] 1197719011453 hinge region; other site 1197719011454 alpha helical domain; other site 1197719011455 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1197719011456 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1197719011457 putative acyl-acceptor binding pocket; other site 1197719011458 DNA polymerase I; Provisional; Region: PRK05755 1197719011459 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1197719011460 active site 1197719011461 metal binding site 1 [ion binding]; metal-binding site 1197719011462 putative 5' ssDNA interaction site; other site 1197719011463 metal binding site 3; metal-binding site 1197719011464 metal binding site 2 [ion binding]; metal-binding site 1197719011465 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1197719011466 putative DNA binding site [nucleotide binding]; other site 1197719011467 putative metal binding site [ion binding]; other site 1197719011468 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1197719011469 active site 1197719011470 catalytic site [active] 1197719011471 substrate binding site [chemical binding]; other site 1197719011472 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1197719011473 active site 1197719011474 DNA binding site [nucleotide binding] 1197719011475 catalytic site [active] 1197719011476 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1197719011477 G1 box; other site 1197719011478 GTP/Mg2+ binding site [chemical binding]; other site 1197719011479 Switch I region; other site 1197719011480 G2 box; other site 1197719011481 G3 box; other site 1197719011482 Switch II region; other site 1197719011483 G4 box; other site 1197719011484 G5 box; other site 1197719011485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1197719011486 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1197719011487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719011488 FeS/SAM binding site; other site 1197719011489 HemN C-terminal domain; Region: HemN_C; pfam06969 1197719011490 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1197719011491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719011492 active site 1197719011493 phosphorylation site [posttranslational modification] 1197719011494 intermolecular recognition site; other site 1197719011495 dimerization interface [polypeptide binding]; other site 1197719011496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719011497 Walker A motif; other site 1197719011498 ATP binding site [chemical binding]; other site 1197719011499 Walker B motif; other site 1197719011500 arginine finger; other site 1197719011501 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1197719011502 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1197719011503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1197719011504 putative active site [active] 1197719011505 heme pocket [chemical binding]; other site 1197719011506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719011507 dimer interface [polypeptide binding]; other site 1197719011508 phosphorylation site [posttranslational modification] 1197719011509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719011510 ATP binding site [chemical binding]; other site 1197719011511 Mg2+ binding site [ion binding]; other site 1197719011512 G-X-G motif; other site 1197719011513 glutamine synthetase; Provisional; Region: glnA; PRK09469 1197719011514 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1197719011515 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1197719011516 GTP-binding protein; Provisional; Region: PRK10218 1197719011517 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1197719011518 G1 box; other site 1197719011519 putative GEF interaction site [polypeptide binding]; other site 1197719011520 GTP/Mg2+ binding site [chemical binding]; other site 1197719011521 Switch I region; other site 1197719011522 G2 box; other site 1197719011523 G3 box; other site 1197719011524 Switch II region; other site 1197719011525 G4 box; other site 1197719011526 G5 box; other site 1197719011527 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1197719011528 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1197719011529 outer membrane porin L; Provisional; Region: ompL; PRK09980 1197719011530 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1197719011531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719011532 putative substrate translocation pore; other site 1197719011533 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1197719011534 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1197719011535 alpha-glucosidase; Provisional; Region: PRK10426 1197719011536 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1197719011537 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1197719011538 putative active site [active] 1197719011539 putative catalytic site [active] 1197719011540 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1197719011541 active site 1197719011542 catalytic residues [active] 1197719011543 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1197719011544 dimerization interface [polypeptide binding]; other site 1197719011545 putative active cleft [active] 1197719011546 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1197719011547 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1197719011548 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1197719011549 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1197719011550 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1197719011551 substrate binding site [chemical binding]; other site 1197719011552 ATP binding site [chemical binding]; other site 1197719011553 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1197719011554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1197719011555 putative DNA binding site [nucleotide binding]; other site 1197719011556 putative Zn2+ binding site [ion binding]; other site 1197719011557 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719011558 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1197719011559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719011560 motif II; other site 1197719011561 hypothetical protein; Reviewed; Region: PRK01637 1197719011562 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1197719011563 putative active site [active] 1197719011564 dimerization interface [polypeptide binding]; other site 1197719011565 putative tRNAtyr binding site [nucleotide binding]; other site 1197719011566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719011567 Coenzyme A binding pocket [chemical binding]; other site 1197719011568 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1197719011569 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1197719011570 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1197719011571 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1197719011572 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1197719011573 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1197719011574 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1197719011575 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719011576 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1197719011577 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1197719011578 molybdopterin cofactor binding site; other site 1197719011579 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719011580 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1197719011581 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1197719011582 AzlC protein; Region: AzlC; cl00570 1197719011583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719011584 non-specific DNA binding site [nucleotide binding]; other site 1197719011585 salt bridge; other site 1197719011586 sequence-specific DNA binding site [nucleotide binding]; other site 1197719011587 Cupin domain; Region: Cupin_2; cl17218 1197719011588 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1197719011589 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1197719011590 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1197719011591 dimer interface [polypeptide binding]; other site 1197719011592 active site 1197719011593 metal binding site [ion binding]; metal-binding site 1197719011594 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1197719011595 intersubunit interface [polypeptide binding]; other site 1197719011596 active site 1197719011597 Zn2+ binding site [ion binding]; other site 1197719011598 L-rhamnose isomerase; Provisional; Region: PRK01076 1197719011599 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1197719011600 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1197719011601 N- and C-terminal domain interface [polypeptide binding]; other site 1197719011602 active site 1197719011603 putative catalytic site [active] 1197719011604 metal binding site [ion binding]; metal-binding site 1197719011605 ATP binding site [chemical binding]; other site 1197719011606 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1197719011607 carbohydrate binding site [chemical binding]; other site 1197719011608 transcriptional activator RhaS; Provisional; Region: PRK13503 1197719011609 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1197719011610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719011611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719011612 transcriptional activator RhaR; Provisional; Region: PRK13502 1197719011613 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1197719011614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719011615 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 1197719011616 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1197719011617 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1197719011618 DctM-like transporters; Region: DctM; pfam06808 1197719011619 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1197719011620 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1197719011621 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1197719011622 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1197719011623 superoxide dismutase; Provisional; Region: PRK10925 1197719011624 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1197719011625 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1197719011626 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1197719011627 MOSC domain; Region: MOSC; pfam03473 1197719011628 3-alpha domain; Region: 3-alpha; pfam03475 1197719011629 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1197719011630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719011631 dimerization interface [polypeptide binding]; other site 1197719011632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719011633 dimer interface [polypeptide binding]; other site 1197719011634 phosphorylation site [posttranslational modification] 1197719011635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719011636 ATP binding site [chemical binding]; other site 1197719011637 Mg2+ binding site [ion binding]; other site 1197719011638 G-X-G motif; other site 1197719011639 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1197719011640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719011641 active site 1197719011642 intermolecular recognition site; other site 1197719011643 dimerization interface [polypeptide binding]; other site 1197719011644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719011645 DNA binding site [nucleotide binding] 1197719011646 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1197719011647 dimer interface [polypeptide binding]; other site 1197719011648 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1197719011649 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1197719011650 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1197719011651 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1197719011652 active site 1197719011653 ADP/pyrophosphate binding site [chemical binding]; other site 1197719011654 dimerization interface [polypeptide binding]; other site 1197719011655 allosteric effector site; other site 1197719011656 fructose-1,6-bisphosphate binding site; other site 1197719011657 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1197719011658 PBP superfamily domain; Region: PBP_like; cl17867 1197719011659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1197719011660 membrane-bound complex binding site; other site 1197719011661 hinge residues; other site 1197719011662 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1197719011663 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719011664 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1197719011665 transmembrane helices; other site 1197719011666 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1197719011667 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1197719011668 transmembrane helices; other site 1197719011669 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1197719011670 triosephosphate isomerase; Provisional; Region: PRK14567 1197719011671 substrate binding site [chemical binding]; other site 1197719011672 dimer interface [polypeptide binding]; other site 1197719011673 catalytic triad [active] 1197719011674 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1197719011675 Predicted membrane protein [Function unknown]; Region: COG3152 1197719011676 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1197719011677 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1197719011678 FAD binding pocket [chemical binding]; other site 1197719011679 FAD binding motif [chemical binding]; other site 1197719011680 phosphate binding motif [ion binding]; other site 1197719011681 beta-alpha-beta structure motif; other site 1197719011682 NAD binding pocket [chemical binding]; other site 1197719011683 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1197719011684 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1197719011685 putative active site [active] 1197719011686 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1197719011687 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1197719011688 active site 1197719011689 Zn binding site [ion binding]; other site 1197719011690 glycerol kinase; Provisional; Region: glpK; PRK00047 1197719011691 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1197719011692 N- and C-terminal domain interface [polypeptide binding]; other site 1197719011693 active site 1197719011694 MgATP binding site [chemical binding]; other site 1197719011695 catalytic site [active] 1197719011696 metal binding site [ion binding]; metal-binding site 1197719011697 glycerol binding site [chemical binding]; other site 1197719011698 homotetramer interface [polypeptide binding]; other site 1197719011699 homodimer interface [polypeptide binding]; other site 1197719011700 FBP binding site [chemical binding]; other site 1197719011701 protein IIAGlc interface [polypeptide binding]; other site 1197719011702 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1197719011703 amphipathic channel; other site 1197719011704 Asn-Pro-Ala signature motifs; other site 1197719011705 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1197719011706 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1197719011707 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1197719011708 UbiA prenyltransferase family; Region: UbiA; pfam01040 1197719011709 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1197719011710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719011711 Walker A motif; other site 1197719011712 ATP binding site [chemical binding]; other site 1197719011713 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1197719011714 Walker B motif; other site 1197719011715 arginine finger; other site 1197719011716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1197719011717 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1197719011718 active site 1197719011719 HslU subunit interaction site [polypeptide binding]; other site 1197719011720 essential cell division protein FtsN; Provisional; Region: PRK10927 1197719011721 cell division protein FtsN; Provisional; Region: PRK12757 1197719011722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719011723 DNA binding site [nucleotide binding] 1197719011724 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1197719011725 domain linker motif; other site 1197719011726 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1197719011727 dimerization interface [polypeptide binding]; other site 1197719011728 ligand binding site [chemical binding]; other site 1197719011729 primosome assembly protein PriA; Validated; Region: PRK05580 1197719011730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719011731 ATP binding site [chemical binding]; other site 1197719011732 putative Mg++ binding site [ion binding]; other site 1197719011733 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1197719011734 ATP-binding site [chemical binding]; other site 1197719011735 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1197719011736 Helix-turn-helix domain; Region: HTH_28; pfam13518 1197719011737 Integrase core domain; Region: rve; pfam00665 1197719011738 Integrase core domain; Region: rve_3; pfam13683 1197719011739 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 1197719011740 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1197719011741 dimerization interface [polypeptide binding]; other site 1197719011742 DNA binding site [nucleotide binding] 1197719011743 corepressor binding sites; other site 1197719011744 cystathionine gamma-synthase; Provisional; Region: PRK08045 1197719011745 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1197719011746 homodimer interface [polypeptide binding]; other site 1197719011747 substrate-cofactor binding pocket; other site 1197719011748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719011749 catalytic residue [active] 1197719011750 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1197719011751 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1197719011752 putative catalytic residues [active] 1197719011753 putative nucleotide binding site [chemical binding]; other site 1197719011754 putative aspartate binding site [chemical binding]; other site 1197719011755 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1197719011756 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1197719011757 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1197719011758 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1197719011759 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1197719011760 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1197719011761 active site 1197719011762 metal binding site [ion binding]; metal-binding site 1197719011763 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1197719011764 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1197719011765 FAD binding site [chemical binding]; other site 1197719011766 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1197719011767 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1197719011768 heme binding site [chemical binding]; other site 1197719011769 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1197719011770 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1197719011771 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1197719011772 dimer interface [polypeptide binding]; other site 1197719011773 active site 1197719011774 metal binding site [ion binding]; metal-binding site 1197719011775 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1197719011776 active site 1197719011777 intersubunit interactions; other site 1197719011778 catalytic residue [active] 1197719011779 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1197719011780 dimerization domain swap beta strand [polypeptide binding]; other site 1197719011781 regulatory protein interface [polypeptide binding]; other site 1197719011782 active site 1197719011783 regulatory phosphorylation site [posttranslational modification]; other site 1197719011784 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1197719011785 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1197719011786 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1197719011787 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1197719011788 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719011789 active site 1197719011790 phosphorylation site [posttranslational modification] 1197719011791 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1197719011792 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1197719011793 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1197719011794 active site 1197719011795 P-loop; other site 1197719011796 phosphorylation site [posttranslational modification] 1197719011797 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1197719011798 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1197719011799 dimer interface [polypeptide binding]; other site 1197719011800 active site 1197719011801 glycine loop; other site 1197719011802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719011803 FeS/SAM binding site; other site 1197719011804 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1197719011805 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1197719011806 active site 1197719011807 P-loop; other site 1197719011808 phosphorylation site [posttranslational modification] 1197719011809 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1197719011810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719011811 hypothetical protein; Provisional; Region: PRK10649 1197719011812 Sulfatase; Region: Sulfatase; pfam00884 1197719011813 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1197719011814 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1197719011815 acetylornithine deacetylase; Provisional; Region: PRK05111 1197719011816 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1197719011817 metal binding site [ion binding]; metal-binding site 1197719011818 putative dimer interface [polypeptide binding]; other site 1197719011819 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1197719011820 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1197719011821 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1197719011822 nucleotide binding site [chemical binding]; other site 1197719011823 N-acetyl-L-glutamate binding site [chemical binding]; other site 1197719011824 argininosuccinate lyase; Provisional; Region: PRK04833 1197719011825 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1197719011826 active sites [active] 1197719011827 tetramer interface [polypeptide binding]; other site 1197719011828 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1197719011829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719011830 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1197719011831 dimerization interface [polypeptide binding]; other site 1197719011832 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1197719011833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1197719011834 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1197719011835 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1197719011836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719011837 hypothetical protein; Provisional; Region: PRK11056 1197719011838 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1197719011839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719011840 S-adenosylmethionine binding site [chemical binding]; other site 1197719011841 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1197719011842 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1197719011843 N-terminal plug; other site 1197719011844 ligand-binding site [chemical binding]; other site 1197719011845 glutamate racemase; Provisional; Region: PRK00865 1197719011846 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1197719011847 FAD binding domain; Region: FAD_binding_4; pfam01565 1197719011848 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1197719011849 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1197719011850 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1197719011851 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1197719011852 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1197719011853 pantothenate kinase; Provisional; Region: PRK05439 1197719011854 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1197719011855 ATP-binding site [chemical binding]; other site 1197719011856 CoA-binding site [chemical binding]; other site 1197719011857 Mg2+-binding site [ion binding]; other site 1197719011858 elongation factor Tu; Reviewed; Region: PRK00049 1197719011859 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1197719011860 G1 box; other site 1197719011861 GEF interaction site [polypeptide binding]; other site 1197719011862 GTP/Mg2+ binding site [chemical binding]; other site 1197719011863 Switch I region; other site 1197719011864 G2 box; other site 1197719011865 G3 box; other site 1197719011866 Switch II region; other site 1197719011867 G4 box; other site 1197719011868 G5 box; other site 1197719011869 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1197719011870 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1197719011871 Antibiotic Binding Site [chemical binding]; other site 1197719011872 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1197719011873 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1197719011874 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1197719011875 putative homodimer interface [polypeptide binding]; other site 1197719011876 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1197719011877 heterodimer interface [polypeptide binding]; other site 1197719011878 homodimer interface [polypeptide binding]; other site 1197719011879 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1197719011880 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1197719011881 23S rRNA interface [nucleotide binding]; other site 1197719011882 L7/L12 interface [polypeptide binding]; other site 1197719011883 putative thiostrepton binding site; other site 1197719011884 L25 interface [polypeptide binding]; other site 1197719011885 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1197719011886 mRNA/rRNA interface [nucleotide binding]; other site 1197719011887 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1197719011888 23S rRNA interface [nucleotide binding]; other site 1197719011889 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1197719011890 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1197719011891 core dimer interface [polypeptide binding]; other site 1197719011892 peripheral dimer interface [polypeptide binding]; other site 1197719011893 L10 interface [polypeptide binding]; other site 1197719011894 L11 interface [polypeptide binding]; other site 1197719011895 putative EF-Tu interaction site [polypeptide binding]; other site 1197719011896 putative EF-G interaction site [polypeptide binding]; other site 1197719011897 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1197719011898 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1197719011899 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1197719011900 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1197719011901 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1197719011902 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1197719011903 RPB3 interaction site [polypeptide binding]; other site 1197719011904 RPB1 interaction site [polypeptide binding]; other site 1197719011905 RPB11 interaction site [polypeptide binding]; other site 1197719011906 RPB10 interaction site [polypeptide binding]; other site 1197719011907 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1197719011908 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1197719011909 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1197719011910 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1197719011911 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1197719011912 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1197719011913 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1197719011914 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1197719011915 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1197719011916 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1197719011917 DNA binding site [nucleotide binding] 1197719011918 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1197719011919 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1197719011920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719011921 FeS/SAM binding site; other site 1197719011922 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1197719011923 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1197719011924 ThiS interaction site; other site 1197719011925 putative active site [active] 1197719011926 tetramer interface [polypeptide binding]; other site 1197719011927 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1197719011928 thiS-thiF/thiG interaction site; other site 1197719011929 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1197719011930 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1197719011931 ATP binding site [chemical binding]; other site 1197719011932 substrate interface [chemical binding]; other site 1197719011933 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1197719011934 thiamine phosphate binding site [chemical binding]; other site 1197719011935 active site 1197719011936 pyrophosphate binding site [ion binding]; other site 1197719011937 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1197719011938 ThiC-associated domain; Region: ThiC-associated; pfam13667 1197719011939 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1197719011940 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1197719011941 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1197719011942 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1197719011943 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1197719011944 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1197719011945 putative NADH binding site [chemical binding]; other site 1197719011946 putative active site [active] 1197719011947 nudix motif; other site 1197719011948 putative metal binding site [ion binding]; other site 1197719011949 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1197719011950 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1197719011951 substrate binding site [chemical binding]; other site 1197719011952 active site 1197719011953 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1197719011954 Active_site [active] 1197719011955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1197719011956 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1197719011957 IHF dimer interface [polypeptide binding]; other site 1197719011958 IHF - DNA interface [nucleotide binding]; other site 1197719011959 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1197719011960 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1197719011961 dimer interface [polypeptide binding]; other site 1197719011962 sensor protein ZraS; Provisional; Region: PRK10364 1197719011963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719011964 dimer interface [polypeptide binding]; other site 1197719011965 phosphorylation site [posttranslational modification] 1197719011966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719011967 ATP binding site [chemical binding]; other site 1197719011968 Mg2+ binding site [ion binding]; other site 1197719011969 G-X-G motif; other site 1197719011970 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1197719011971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719011972 active site 1197719011973 phosphorylation site [posttranslational modification] 1197719011974 intermolecular recognition site; other site 1197719011975 dimerization interface [polypeptide binding]; other site 1197719011976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719011977 Walker A motif; other site 1197719011978 ATP binding site [chemical binding]; other site 1197719011979 Walker B motif; other site 1197719011980 arginine finger; other site 1197719011981 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1197719011982 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1197719011983 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1197719011984 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1197719011985 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1197719011986 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1197719011987 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1197719011988 purine monophosphate binding site [chemical binding]; other site 1197719011989 dimer interface [polypeptide binding]; other site 1197719011990 putative catalytic residues [active] 1197719011991 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1197719011992 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1197719011993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1197719011994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719011995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1197719011996 Coenzyme A binding pocket [chemical binding]; other site 1197719011997 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1197719011998 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1197719011999 proposed active site lysine [active] 1197719012000 conserved cys residue [active] 1197719012001 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1197719012002 malate synthase A; Region: malate_syn_A; TIGR01344 1197719012003 active site 1197719012004 isocitrate lyase; Provisional; Region: PRK15063 1197719012005 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1197719012006 tetramer interface [polypeptide binding]; other site 1197719012007 active site 1197719012008 Mg2+/Mn2+ binding site [ion binding]; other site 1197719012009 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1197719012010 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1197719012011 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1197719012012 transcriptional repressor IclR; Provisional; Region: PRK11569 1197719012013 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1197719012014 Bacterial transcriptional regulator; Region: IclR; pfam01614 1197719012015 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1197719012016 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1197719012017 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1197719012018 substrate binding pocket [chemical binding]; other site 1197719012019 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1197719012020 B12 binding site [chemical binding]; other site 1197719012021 cobalt ligand [ion binding]; other site 1197719012022 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1197719012023 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1197719012024 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1197719012025 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1197719012026 active site pocket [active] 1197719012027 oxyanion hole [active] 1197719012028 catalytic triad [active] 1197719012029 active site nucleophile [active] 1197719012030 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1197719012031 DNA-binding site [nucleotide binding]; DNA binding site 1197719012032 RNA-binding motif; other site 1197719012033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1197719012034 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1197719012035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1197719012036 RNA binding surface [nucleotide binding]; other site 1197719012037 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1197719012038 probable active site [active] 1197719012039 hypothetical protein; Provisional; Region: PRK10515 1197719012040 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1197719012041 Sodium Bile acid symporter family; Region: SBF; pfam01758 1197719012042 aspartate kinase III; Validated; Region: PRK09084 1197719012043 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1197719012044 nucleotide binding site [chemical binding]; other site 1197719012045 substrate binding site [chemical binding]; other site 1197719012046 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1197719012047 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1197719012048 dimer interface [polypeptide binding]; other site 1197719012049 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1197719012050 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1197719012051 active site 1197719012052 dimer interface [polypeptide binding]; other site 1197719012053 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1197719012054 dimer interface [polypeptide binding]; other site 1197719012055 active site 1197719012056 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1197719012057 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1197719012058 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1197719012059 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1197719012060 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1197719012061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719012062 putative substrate translocation pore; other site 1197719012063 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1197719012064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719012065 dimer interface [polypeptide binding]; other site 1197719012066 conserved gate region; other site 1197719012067 putative PBP binding loops; other site 1197719012068 ABC-ATPase subunit interface; other site 1197719012069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1197719012070 dimer interface [polypeptide binding]; other site 1197719012071 conserved gate region; other site 1197719012072 putative PBP binding loops; other site 1197719012073 ABC-ATPase subunit interface; other site 1197719012074 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1197719012075 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1197719012076 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1197719012077 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1197719012078 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1197719012079 Walker A/P-loop; other site 1197719012080 ATP binding site [chemical binding]; other site 1197719012081 Q-loop/lid; other site 1197719012082 ABC transporter signature motif; other site 1197719012083 Walker B; other site 1197719012084 D-loop; other site 1197719012085 H-loop/switch region; other site 1197719012086 TOBE domain; Region: TOBE_2; pfam08402 1197719012087 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1197719012088 trimer interface; other site 1197719012089 sugar binding site [chemical binding]; other site 1197719012090 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1197719012091 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1197719012092 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1197719012093 UbiA prenyltransferase family; Region: UbiA; pfam01040 1197719012094 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1197719012095 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1197719012096 putative acyl-acceptor binding pocket; other site 1197719012097 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1197719012098 LexA repressor; Validated; Region: PRK00215 1197719012099 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1197719012100 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1197719012101 Catalytic site [active] 1197719012102 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1197719012103 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1197719012104 hypothetical protein; Provisional; Region: PRK10428 1197719012105 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1197719012106 metal binding site 2 [ion binding]; metal-binding site 1197719012107 putative DNA binding helix; other site 1197719012108 metal binding site 1 [ion binding]; metal-binding site 1197719012109 dimer interface [polypeptide binding]; other site 1197719012110 structural Zn2+ binding site [ion binding]; other site 1197719012111 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1197719012112 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1197719012113 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1197719012114 FMN binding site [chemical binding]; other site 1197719012115 active site 1197719012116 catalytic residues [active] 1197719012117 substrate binding site [chemical binding]; other site 1197719012118 phage shock protein G; Reviewed; Region: pspG; PRK09459 1197719012119 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1197719012120 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1197719012121 NADP binding site [chemical binding]; other site 1197719012122 dimer interface [polypeptide binding]; other site 1197719012123 replicative DNA helicase; Provisional; Region: PRK08006 1197719012124 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1197719012125 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1197719012126 Walker A motif; other site 1197719012127 ATP binding site [chemical binding]; other site 1197719012128 Walker B motif; other site 1197719012129 DNA binding loops [nucleotide binding] 1197719012130 alanine racemase; Reviewed; Region: alr; PRK00053 1197719012131 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1197719012132 active site 1197719012133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1197719012134 substrate binding site [chemical binding]; other site 1197719012135 catalytic residues [active] 1197719012136 dimer interface [polypeptide binding]; other site 1197719012137 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1197719012138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1197719012139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719012140 homodimer interface [polypeptide binding]; other site 1197719012141 catalytic residue [active] 1197719012142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719012143 active site 1197719012144 motif I; other site 1197719012145 motif II; other site 1197719012146 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1197719012147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1197719012148 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1197719012149 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1197719012150 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1197719012151 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1197719012152 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1197719012153 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1197719012154 dimer interface [polypeptide binding]; other site 1197719012155 ssDNA binding site [nucleotide binding]; other site 1197719012156 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1197719012157 hypothetical protein; Validated; Region: PRK09039 1197719012158 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1197719012159 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1197719012160 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1197719012161 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719012162 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012163 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719012164 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012165 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012166 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012167 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012168 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012169 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012170 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012171 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012172 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012173 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012174 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012175 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012176 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012177 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012178 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012179 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012180 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012181 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012182 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012183 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012184 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012185 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1197719012186 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012187 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012188 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012189 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012190 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012191 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012192 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012193 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 1197719012194 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012195 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012196 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719012197 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012198 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1197719012199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719012200 Walker A/P-loop; other site 1197719012201 ATP binding site [chemical binding]; other site 1197719012202 Q-loop/lid; other site 1197719012203 ABC transporter signature motif; other site 1197719012204 Walker B; other site 1197719012205 D-loop; other site 1197719012206 H-loop/switch region; other site 1197719012207 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1197719012208 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1197719012209 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1197719012210 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1197719012211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719012212 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1197719012213 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1197719012214 DNA binding residues [nucleotide binding] 1197719012215 dimer interface [polypeptide binding]; other site 1197719012216 [2Fe-2S] cluster binding site [ion binding]; other site 1197719012217 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1197719012218 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1197719012219 putative C-terminal domain interface [polypeptide binding]; other site 1197719012220 putative GSH binding site (G-site) [chemical binding]; other site 1197719012221 putative dimer interface [polypeptide binding]; other site 1197719012222 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1197719012223 putative N-terminal domain interface [polypeptide binding]; other site 1197719012224 putative dimer interface [polypeptide binding]; other site 1197719012225 putative substrate binding pocket (H-site) [chemical binding]; other site 1197719012226 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1197719012227 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1197719012228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1197719012229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719012230 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1197719012231 putative dimerization interface [polypeptide binding]; other site 1197719012232 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1197719012233 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1197719012234 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1197719012235 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1197719012236 Na binding site [ion binding]; other site 1197719012237 Predicted membrane protein [Function unknown]; Region: COG3162 1197719012238 acetyl-CoA synthetase; Provisional; Region: PRK00174 1197719012239 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1197719012240 active site 1197719012241 CoA binding site [chemical binding]; other site 1197719012242 acyl-activating enzyme (AAE) consensus motif; other site 1197719012243 AMP binding site [chemical binding]; other site 1197719012244 acetate binding site [chemical binding]; other site 1197719012245 Cytochrome C biogenesis protein; Region: CcmH; cl01179 1197719012246 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1197719012247 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1197719012248 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1197719012249 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1197719012250 Sel1-like repeats; Region: SEL1; smart00671 1197719012251 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719012252 molybdopterin cofactor binding site; other site 1197719012253 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1197719012254 molybdopterin cofactor binding site; other site 1197719012255 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1197719012256 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1197719012257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1197719012258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719012259 Coenzyme A binding pocket [chemical binding]; other site 1197719012260 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1197719012261 dimer interface [polypeptide binding]; other site 1197719012262 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1197719012263 hypothetical protein; Provisional; Region: PRK10220 1197719012264 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1197719012265 PhnA protein; Region: PhnA; pfam03831 1197719012266 proline/glycine betaine transporter; Provisional; Region: PRK10642 1197719012267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719012268 putative substrate translocation pore; other site 1197719012269 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1197719012270 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1197719012271 HAMP domain; Region: HAMP; pfam00672 1197719012272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719012273 dimer interface [polypeptide binding]; other site 1197719012274 phosphorylation site [posttranslational modification] 1197719012275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719012276 ATP binding site [chemical binding]; other site 1197719012277 Mg2+ binding site [ion binding]; other site 1197719012278 G-X-G motif; other site 1197719012279 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1197719012280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719012281 active site 1197719012282 phosphorylation site [posttranslational modification] 1197719012283 intermolecular recognition site; other site 1197719012284 dimerization interface [polypeptide binding]; other site 1197719012285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719012286 DNA binding site [nucleotide binding] 1197719012287 putative metal dependent hydrolase; Provisional; Region: PRK11598 1197719012288 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1197719012289 Sulfatase; Region: Sulfatase; pfam00884 1197719012290 arginine:agmatin antiporter; Provisional; Region: PRK10644 1197719012291 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1197719012292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719012293 arginine decarboxylase; Provisional; Region: PRK15029 1197719012294 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1197719012295 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1197719012296 homodimer interface [polypeptide binding]; other site 1197719012297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1197719012298 catalytic residue [active] 1197719012299 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1197719012300 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1197719012301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719012302 alpha-galactosidase; Provisional; Region: PRK15076 1197719012303 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1197719012304 NAD binding site [chemical binding]; other site 1197719012305 sugar binding site [chemical binding]; other site 1197719012306 divalent metal binding site [ion binding]; other site 1197719012307 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1197719012308 dimer interface [polypeptide binding]; other site 1197719012309 melibiose:sodium symporter; Provisional; Region: PRK10429 1197719012310 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1197719012311 fumarate hydratase; Provisional; Region: PRK15389 1197719012312 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1197719012313 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1197719012314 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1197719012315 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1197719012316 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1197719012317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719012318 active site 1197719012319 phosphorylation site [posttranslational modification] 1197719012320 intermolecular recognition site; other site 1197719012321 dimerization interface [polypeptide binding]; other site 1197719012322 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1197719012323 PAS domain; Region: PAS; smart00091 1197719012324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719012325 ATP binding site [chemical binding]; other site 1197719012326 Mg2+ binding site [ion binding]; other site 1197719012327 G-X-G motif; other site 1197719012328 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1197719012329 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1197719012330 Walker A/P-loop; other site 1197719012331 ATP binding site [chemical binding]; other site 1197719012332 Q-loop/lid; other site 1197719012333 ABC transporter signature motif; other site 1197719012334 Walker B; other site 1197719012335 D-loop; other site 1197719012336 H-loop/switch region; other site 1197719012337 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1197719012338 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1197719012339 ABC-ATPase subunit interface; other site 1197719012340 dimer interface [polypeptide binding]; other site 1197719012341 putative PBP binding regions; other site 1197719012342 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 1197719012343 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1197719012344 putative hemin binding site; other site 1197719012345 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1197719012346 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1197719012347 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1197719012348 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1197719012349 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1197719012350 N-terminal plug; other site 1197719012351 ligand-binding site [chemical binding]; other site 1197719012352 Hemin uptake protein hemP; Region: hemP; cl10043 1197719012353 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1197719012354 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1197719012355 putative [Fe4-S4] binding site [ion binding]; other site 1197719012356 putative molybdopterin cofactor binding site [chemical binding]; other site 1197719012357 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1197719012358 putative molybdopterin cofactor binding site; other site 1197719012359 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1197719012360 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1197719012361 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1197719012362 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1197719012363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1197719012364 SdiA-regulated; Region: SdiA-regulated; cd09971 1197719012365 putative active site [active] 1197719012366 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 1197719012367 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 1197719012368 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719012369 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012370 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012371 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719012372 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012373 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012374 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012375 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012376 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012377 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012378 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012379 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012380 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719012381 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012382 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012383 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012384 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1197719012385 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012386 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1197719012387 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1197719012388 HlyD family secretion protein; Region: HlyD_3; pfam13437 1197719012389 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1197719012390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719012391 Q-loop/lid; other site 1197719012392 ABC transporter signature motif; other site 1197719012393 Walker B; other site 1197719012394 D-loop; other site 1197719012395 H-loop/switch region; other site 1197719012396 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1197719012397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719012398 DNA binding residues [nucleotide binding] 1197719012399 dimerization interface [polypeptide binding]; other site 1197719012400 AraC family transcriptional regulator; Provisional; Region: PRK15186 1197719012401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719012402 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719012403 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719012404 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719012405 RHS protein; Region: RHS; pfam03527 1197719012406 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719012407 PAAR motif; Region: PAAR_motif; cl15808 1197719012408 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719012409 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1197719012410 RHS Repeat; Region: RHS_repeat; pfam05593 1197719012411 RHS Repeat; Region: RHS_repeat; pfam05593 1197719012412 RHS protein; Region: RHS; pfam03527 1197719012413 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1197719012414 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1197719012415 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1197719012416 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1197719012417 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1197719012418 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1197719012419 putative transcriptional regulator; Provisional; Region: PRK11640 1197719012420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1197719012421 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1197719012422 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1197719012423 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1197719012424 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1197719012425 DsbD alpha interface [polypeptide binding]; other site 1197719012426 catalytic residues [active] 1197719012427 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1197719012428 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1197719012429 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1197719012430 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1197719012431 Aspartase; Region: Aspartase; cd01357 1197719012432 active sites [active] 1197719012433 tetramer interface [polypeptide binding]; other site 1197719012434 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1197719012435 putative transporter; Provisional; Region: PRK11021 1197719012436 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1197719012437 oligomerisation interface [polypeptide binding]; other site 1197719012438 mobile loop; other site 1197719012439 roof hairpin; other site 1197719012440 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1197719012441 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1197719012442 ring oligomerisation interface [polypeptide binding]; other site 1197719012443 ATP/Mg binding site [chemical binding]; other site 1197719012444 stacking interactions; other site 1197719012445 hinge regions; other site 1197719012446 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1197719012447 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1197719012448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719012449 FeS/SAM binding site; other site 1197719012450 elongation factor P; Validated; Region: PRK00529 1197719012451 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1197719012452 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1197719012453 RNA binding site [nucleotide binding]; other site 1197719012454 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1197719012455 RNA binding site [nucleotide binding]; other site 1197719012456 Predicted small secreted protein [Function unknown]; Region: COG5510 1197719012457 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1197719012458 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719012459 DNA binding residues [nucleotide binding] 1197719012460 dimerization interface [polypeptide binding]; other site 1197719012461 multidrug efflux system protein; Provisional; Region: PRK11431 1197719012462 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1197719012463 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1197719012464 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1197719012465 Iron-sulfur protein interface; other site 1197719012466 proximal quinone binding site [chemical binding]; other site 1197719012467 C-subunit interface; other site 1197719012468 distal quinone binding site; other site 1197719012469 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1197719012470 D-subunit interface [polypeptide binding]; other site 1197719012471 Iron-sulfur protein interface; other site 1197719012472 proximal quinone binding site [chemical binding]; other site 1197719012473 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1197719012474 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1197719012475 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1197719012476 L-aspartate oxidase; Provisional; Region: PRK06175 1197719012477 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1197719012478 poxB regulator PoxA; Provisional; Region: PRK09350 1197719012479 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1197719012480 motif 1; other site 1197719012481 dimer interface [polypeptide binding]; other site 1197719012482 active site 1197719012483 motif 2; other site 1197719012484 motif 3; other site 1197719012485 inner membrane transporter YjeM; Provisional; Region: PRK15238 1197719012486 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1197719012487 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1197719012488 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1197719012489 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1197719012490 GTPase RsgA; Reviewed; Region: PRK12288 1197719012491 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1197719012492 RNA binding site [nucleotide binding]; other site 1197719012493 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1197719012494 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1197719012495 GTP/Mg2+ binding site [chemical binding]; other site 1197719012496 G4 box; other site 1197719012497 G5 box; other site 1197719012498 G1 box; other site 1197719012499 Switch I region; other site 1197719012500 G2 box; other site 1197719012501 G3 box; other site 1197719012502 Switch II region; other site 1197719012503 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1197719012504 catalytic site [active] 1197719012505 putative active site [active] 1197719012506 putative substrate binding site [chemical binding]; other site 1197719012507 dimer interface [polypeptide binding]; other site 1197719012508 epoxyqueuosine reductase; Region: TIGR00276 1197719012509 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1197719012510 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1197719012511 putative carbohydrate kinase; Provisional; Region: PRK10565 1197719012512 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1197719012513 putative substrate binding site [chemical binding]; other site 1197719012514 putative ATP binding site [chemical binding]; other site 1197719012515 ADP-binding protein; Provisional; Region: PRK10646 1197719012516 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1197719012517 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1197719012518 active site 1197719012519 metal binding site [ion binding]; metal-binding site 1197719012520 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1197719012521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719012522 ATP binding site [chemical binding]; other site 1197719012523 Mg2+ binding site [ion binding]; other site 1197719012524 G-X-G motif; other site 1197719012525 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1197719012526 ATP binding site [chemical binding]; other site 1197719012527 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1197719012528 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1197719012529 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1197719012530 bacterial Hfq-like; Region: Hfq; cd01716 1197719012531 hexamer interface [polypeptide binding]; other site 1197719012532 Sm1 motif; other site 1197719012533 RNA binding site [nucleotide binding]; other site 1197719012534 Sm2 motif; other site 1197719012535 GTPase HflX; Provisional; Region: PRK11058 1197719012536 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1197719012537 HflX GTPase family; Region: HflX; cd01878 1197719012538 G1 box; other site 1197719012539 GTP/Mg2+ binding site [chemical binding]; other site 1197719012540 Switch I region; other site 1197719012541 G2 box; other site 1197719012542 G3 box; other site 1197719012543 Switch II region; other site 1197719012544 G4 box; other site 1197719012545 G5 box; other site 1197719012546 FtsH protease regulator HflK; Provisional; Region: PRK10930 1197719012547 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1197719012548 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1197719012549 FtsH protease regulator HflC; Provisional; Region: PRK11029 1197719012550 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1197719012551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1197719012552 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1197719012553 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1197719012554 GDP-binding site [chemical binding]; other site 1197719012555 ACT binding site; other site 1197719012556 IMP binding site; other site 1197719012557 Predicted transcriptional regulator [Transcription]; Region: COG1959 1197719012558 transcriptional repressor NsrR; Provisional; Region: PRK11014 1197719012559 exoribonuclease R; Provisional; Region: PRK11642 1197719012560 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1197719012561 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1197719012562 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1197719012563 RNB domain; Region: RNB; pfam00773 1197719012564 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1197719012565 RNA binding site [nucleotide binding]; other site 1197719012566 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1197719012567 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1197719012568 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1197719012569 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1197719012570 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1197719012571 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1197719012572 Predicted membrane protein [Function unknown]; Region: COG3766 1197719012573 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1197719012574 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1197719012575 Predicted integral membrane protein [Function unknown]; Region: COG5463 1197719012576 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1197719012577 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1197719012578 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1197719012579 FAD binding site [chemical binding]; other site 1197719012580 substrate binding site [chemical binding]; other site 1197719012581 catalytic residues [active] 1197719012582 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719012583 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1197719012584 esterase; Provisional; Region: PRK10566 1197719012585 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1197719012586 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1197719012587 transcriptional repressor UlaR; Provisional; Region: PRK13509 1197719012588 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1197719012589 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1197719012590 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1197719012591 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1197719012592 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1197719012593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1197719012594 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1197719012595 active site 1197719012596 P-loop; other site 1197719012597 phosphorylation site [posttranslational modification] 1197719012598 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719012599 active site 1197719012600 phosphorylation site [posttranslational modification] 1197719012601 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1197719012602 active site 1197719012603 dimer interface [polypeptide binding]; other site 1197719012604 magnesium binding site [ion binding]; other site 1197719012605 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1197719012606 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1197719012607 AP (apurinic/apyrimidinic) site pocket; other site 1197719012608 DNA interaction; other site 1197719012609 Metal-binding active site; metal-binding site 1197719012610 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1197719012611 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1197719012612 intersubunit interface [polypeptide binding]; other site 1197719012613 active site 1197719012614 Zn2+ binding site [ion binding]; other site 1197719012615 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1197719012616 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1197719012617 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1197719012618 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1197719012619 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1197719012620 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1197719012621 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1197719012622 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1197719012623 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1197719012624 EamA-like transporter family; Region: EamA; pfam00892 1197719012625 EamA-like transporter family; Region: EamA; pfam00892 1197719012626 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1197719012627 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1197719012628 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1197719012629 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1197719012630 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1197719012631 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1197719012632 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1197719012633 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1197719012634 Hemerythrin-like domain; Region: Hr-like; cd12108 1197719012635 Fe binding site [ion binding]; other site 1197719012636 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1197719012637 EamA-like transporter family; Region: EamA; pfam00892 1197719012638 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1197719012639 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1197719012640 NADP binding site [chemical binding]; other site 1197719012641 Predicted transcriptional regulators [Transcription]; Region: COG1733 1197719012642 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1197719012643 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1197719012644 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1197719012645 active site 1197719012646 metal binding site [ion binding]; metal-binding site 1197719012647 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1197719012648 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1197719012649 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1197719012650 active site 1197719012651 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1197719012652 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1197719012653 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1197719012654 Domain of unknown function DUF21; Region: DUF21; pfam01595 1197719012655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1197719012656 Transporter associated domain; Region: CorC_HlyC; smart01091 1197719012657 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1197719012658 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1197719012659 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1197719012660 Surface antigen; Region: Bac_surface_Ag; pfam01103 1197719012661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1197719012662 Family of unknown function (DUF490); Region: DUF490; pfam04357 1197719012663 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1197719012664 dimerization interface [polypeptide binding]; other site 1197719012665 putative active site pocket [active] 1197719012666 putative catalytic residue [active] 1197719012667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719012668 D-galactonate transporter; Region: 2A0114; TIGR00893 1197719012669 putative substrate translocation pore; other site 1197719012670 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1197719012671 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1197719012672 active site 1197719012673 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1197719012674 dimer interface [polypeptide binding]; other site 1197719012675 substrate binding site [chemical binding]; other site 1197719012676 metal binding sites [ion binding]; metal-binding site 1197719012677 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1197719012678 AMP binding site [chemical binding]; other site 1197719012679 metal binding site [ion binding]; metal-binding site 1197719012680 active site 1197719012681 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1197719012682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1197719012683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1197719012684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1197719012685 hypothetical protein; Provisional; Region: PRK05255 1197719012686 peptidase PmbA; Provisional; Region: PRK11040 1197719012687 cytochrome b562; Provisional; Region: PRK15058 1197719012688 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1197719012689 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1197719012690 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1197719012691 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1197719012692 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1197719012693 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1197719012694 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1197719012695 active site 1197719012696 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1197719012697 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1197719012698 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1197719012699 HTH domain; Region: HTH_11; pfam08279 1197719012700 Mga helix-turn-helix domain; Region: Mga; pfam05043 1197719012701 PRD domain; Region: PRD; pfam00874 1197719012702 PRD domain; Region: PRD; pfam00874 1197719012703 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1197719012704 active site 1197719012705 P-loop; other site 1197719012706 phosphorylation site [posttranslational modification] 1197719012707 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1197719012708 active site 1197719012709 phosphorylation site [posttranslational modification] 1197719012710 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1197719012711 oligomeric interface; other site 1197719012712 putative active site [active] 1197719012713 homodimer interface [polypeptide binding]; other site 1197719012714 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1197719012715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1197719012716 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 1197719012717 FeS/SAM binding site; other site 1197719012718 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1197719012719 ATP cone domain; Region: ATP-cone; pfam03477 1197719012720 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1197719012721 effector binding site; other site 1197719012722 active site 1197719012723 Zn binding site [ion binding]; other site 1197719012724 glycine loop; other site 1197719012725 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1197719012726 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1197719012727 Ca binding site [ion binding]; other site 1197719012728 active site 1197719012729 catalytic site [active] 1197719012730 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1197719012731 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1197719012732 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1197719012733 active site turn [active] 1197719012734 phosphorylation site [posttranslational modification] 1197719012735 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1197719012736 trehalose repressor; Provisional; Region: treR; PRK09492 1197719012737 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719012738 DNA binding site [nucleotide binding] 1197719012739 domain linker motif; other site 1197719012740 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1197719012741 dimerization interface [polypeptide binding]; other site 1197719012742 ligand binding site [chemical binding]; other site 1197719012743 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1197719012744 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1197719012745 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1197719012746 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1197719012747 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1197719012748 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1197719012749 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1197719012750 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1197719012751 homotrimer interaction site [polypeptide binding]; other site 1197719012752 putative active site [active] 1197719012753 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1197719012754 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1197719012755 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1197719012756 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1197719012757 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1197719012758 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1197719012759 Arginine repressor [Transcription]; Region: ArgR; COG1438 1197719012760 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1197719012761 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1197719012762 Predicted membrane protein [Function unknown]; Region: COG1288 1197719012763 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1197719012764 ornithine carbamoyltransferase; Validated; Region: PRK02102 1197719012765 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1197719012766 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1197719012767 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1197719012768 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1197719012769 putative substrate binding site [chemical binding]; other site 1197719012770 nucleotide binding site [chemical binding]; other site 1197719012771 nucleotide binding site [chemical binding]; other site 1197719012772 homodimer interface [polypeptide binding]; other site 1197719012773 arginine deiminase; Provisional; Region: PRK01388 1197719012774 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1197719012775 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1197719012776 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1197719012777 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1197719012778 RNase E inhibitor protein; Provisional; Region: PRK11191 1197719012779 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1197719012780 active site 1197719012781 dinuclear metal binding site [ion binding]; other site 1197719012782 dimerization interface [polypeptide binding]; other site 1197719012783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1197719012784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719012785 Coenzyme A binding pocket [chemical binding]; other site 1197719012786 Predicted membrane protein [Function unknown]; Region: COG4269 1197719012787 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1197719012788 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1197719012789 HIGH motif; other site 1197719012790 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1197719012791 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1197719012792 active site 1197719012793 KMSKS motif; other site 1197719012794 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1197719012795 tRNA binding surface [nucleotide binding]; other site 1197719012796 anticodon binding site; other site 1197719012797 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1197719012798 DNA polymerase III subunit chi; Validated; Region: PRK05728 1197719012799 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1197719012800 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1197719012801 interface (dimer of trimers) [polypeptide binding]; other site 1197719012802 Substrate-binding/catalytic site; other site 1197719012803 Zn-binding sites [ion binding]; other site 1197719012804 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1197719012805 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1197719012806 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1197719012807 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1197719012808 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1197719012809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1197719012810 DNA binding site [nucleotide binding] 1197719012811 domain linker motif; other site 1197719012812 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1197719012813 putative dimerization interface [polypeptide binding]; other site 1197719012814 putative ligand binding site [chemical binding]; other site 1197719012815 gluconate transporter; Region: gntP; TIGR00791 1197719012816 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1197719012817 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1197719012818 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1197719012819 NADP binding site [chemical binding]; other site 1197719012820 homodimer interface [polypeptide binding]; other site 1197719012821 active site 1197719012822 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1197719012823 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1197719012824 putative NAD(P) binding site [chemical binding]; other site 1197719012825 catalytic Zn binding site [ion binding]; other site 1197719012826 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1197719012827 ATP-binding site [chemical binding]; other site 1197719012828 Gluconate-6-phosphate binding site [chemical binding]; other site 1197719012829 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1197719012830 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1197719012831 putative NAD(P) binding site [chemical binding]; other site 1197719012832 putative substrate binding site [chemical binding]; other site 1197719012833 catalytic Zn binding site [ion binding]; other site 1197719012834 structural Zn binding site [ion binding]; other site 1197719012835 dimer interface [polypeptide binding]; other site 1197719012836 integrase; Provisional; Region: PRK09692 1197719012837 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1197719012838 active site 1197719012839 Int/Topo IB signature motif; other site 1197719012840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719012841 Coenzyme A binding pocket [chemical binding]; other site 1197719012842 Putative helicase; Region: TraI_2; pfam07514 1197719012843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1197719012844 Zn2+ binding site [ion binding]; other site 1197719012845 Mg2+ binding site [ion binding]; other site 1197719012846 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1197719012847 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1197719012848 homotrimer interaction site [polypeptide binding]; other site 1197719012849 putative active site [active] 1197719012850 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1197719012851 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1197719012852 Glycogen synthesis protein; Region: GlgS; cl11663 1197719012853 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1197719012854 HNH endonuclease; Region: HNH_2; pfam13391 1197719012855 Protein of unknown function (DUF511); Region: DUF511; pfam04373 1197719012856 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1197719012857 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1197719012858 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1197719012859 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1197719012860 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1197719012861 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1197719012862 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1197719012863 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1197719012864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1197719012865 ATP binding site [chemical binding]; other site 1197719012866 putative Mg++ binding site [ion binding]; other site 1197719012867 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1197719012868 Protein of unknown function DUF45; Region: DUF45; pfam01863 1197719012869 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1197719012870 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1197719012871 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1197719012872 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1197719012873 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1197719012874 active site 1197719012875 DNA binding site [nucleotide binding] 1197719012876 Int/Topo IB signature motif; other site 1197719012877 Fimbrial protein; Region: Fimbrial; cl01416 1197719012878 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1197719012879 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719012880 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719012881 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1197719012882 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719012883 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719012884 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719012885 Fimbrial protein; Region: Fimbrial; cl01416 1197719012886 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1197719012887 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1197719012888 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1197719012889 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1197719012890 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1197719012891 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1197719012892 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 1197719012893 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 1197719012894 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1197719012895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719012896 non-specific DNA binding site [nucleotide binding]; other site 1197719012897 salt bridge; other site 1197719012898 sequence-specific DNA binding site [nucleotide binding]; other site 1197719012899 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1197719012900 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1197719012901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719012902 Walker A motif; other site 1197719012903 ATP binding site [chemical binding]; other site 1197719012904 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1197719012905 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1197719012906 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 1197719012907 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1197719012908 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 1197719012909 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1197719012910 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1197719012911 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1197719012912 AAA domain; Region: AAA_21; pfam13304 1197719012913 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1197719012914 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 1197719012915 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1197719012916 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1197719012917 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1197719012918 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1197719012919 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1197719012920 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1197719012921 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1197719012922 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1197719012923 putative dimer interface [polypeptide binding]; other site 1197719012924 DNA topoisomerase III; Provisional; Region: PRK07726 1197719012925 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1197719012926 active site 1197719012927 putative interdomain interaction site [polypeptide binding]; other site 1197719012928 putative metal-binding site [ion binding]; other site 1197719012929 putative nucleotide binding site [chemical binding]; other site 1197719012930 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1197719012931 domain I; other site 1197719012932 DNA binding groove [nucleotide binding] 1197719012933 phosphate binding site [ion binding]; other site 1197719012934 domain II; other site 1197719012935 domain III; other site 1197719012936 nucleotide binding site [chemical binding]; other site 1197719012937 catalytic site [active] 1197719012938 domain IV; other site 1197719012939 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 1197719012940 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 1197719012941 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1197719012942 ParB-like nuclease domain; Region: ParBc; pfam02195 1197719012943 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1197719012944 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1197719012945 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1197719012946 HNH endonuclease; Region: HNH_2; pfam13391 1197719012947 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1197719012948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719012949 S-adenosylmethionine binding site [chemical binding]; other site 1197719012950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719012951 S-adenosylmethionine binding site [chemical binding]; other site 1197719012952 hypothetical protein; Provisional; Region: PRK13687 1197719012953 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1197719012954 Protein of unknown function DUF91; Region: DUF91; cl00709 1197719012955 Uncharacterized conserved protein [Function unknown]; Region: COG3439 1197719012956 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1197719012957 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1197719012958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1197719012959 DNA-binding site [nucleotide binding]; DNA binding site 1197719012960 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1197719012961 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1197719012962 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1197719012963 active site 1197719012964 HIGH motif; other site 1197719012965 dimer interface [polypeptide binding]; other site 1197719012966 KMSKS motif; other site 1197719012967 Protein of unknown function (DUF796); Region: DUF796; cl01226 1197719012968 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1197719012969 aspartate racemase; Region: asp_race; TIGR00035 1197719012970 cell density-dependent motility repressor; Provisional; Region: PRK10082 1197719012971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1197719012972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1197719012973 dimerization interface [polypeptide binding]; other site 1197719012974 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1197719012975 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1197719012976 dimer interface [polypeptide binding]; other site 1197719012977 active site 1197719012978 hypothetical protein; Provisional; Region: PRK10519 1197719012979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1197719012980 Nucleoside recognition; Region: Gate; pfam07670 1197719012981 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1197719012982 Predicted membrane protein [Function unknown]; Region: COG2733 1197719012983 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1197719012984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1197719012985 putative substrate translocation pore; other site 1197719012986 putative transposase; Provisional; Region: PRK09857 1197719012987 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719012988 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1197719012989 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1197719012990 NAD(P) binding site [chemical binding]; other site 1197719012991 catalytic residues [active] 1197719012992 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 1197719012993 Protein of unknown function DUF91; Region: DUF91; cl00709 1197719012994 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1197719012995 endoribonuclease SymE; Provisional; Region: PRK13605 1197719012996 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1197719012997 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1197719012998 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1197719012999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719013000 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1197719013001 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1197719013002 P-loop, Walker A motif; other site 1197719013003 Base recognition motif; other site 1197719013004 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1197719013005 Uncharacterized small protein [Function unknown]; Region: COG2879 1197719013006 carbon starvation protein A; Provisional; Region: PRK15015 1197719013007 Carbon starvation protein CstA; Region: CstA; pfam02554 1197719013008 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1197719013009 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1197719013010 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1197719013011 dimer interface [polypeptide binding]; other site 1197719013012 ligand binding site [chemical binding]; other site 1197719013013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1197719013014 dimerization interface [polypeptide binding]; other site 1197719013015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1197719013016 dimer interface [polypeptide binding]; other site 1197719013017 putative CheW interface [polypeptide binding]; other site 1197719013018 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1197719013019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719013020 Walker A motif; other site 1197719013021 ATP binding site [chemical binding]; other site 1197719013022 Walker B motif; other site 1197719013023 arginine finger; other site 1197719013024 Transcriptional antiterminator [Transcription]; Region: COG3933 1197719013025 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1197719013026 active pocket/dimerization site; other site 1197719013027 active site 1197719013028 phosphorylation site [posttranslational modification] 1197719013029 PRD domain; Region: PRD; pfam00874 1197719013030 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1197719013031 active pocket/dimerization site; other site 1197719013032 active site 1197719013033 phosphorylation site [posttranslational modification] 1197719013034 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1197719013035 active site 1197719013036 phosphorylation site [posttranslational modification] 1197719013037 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1197719013038 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1197719013039 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1197719013040 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1197719013041 dimer interface [polypeptide binding]; other site 1197719013042 active site 1197719013043 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1197719013044 dimer interface [polypeptide binding]; other site 1197719013045 active site 1197719013046 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1197719013047 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1197719013048 putative active site [active] 1197719013049 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1197719013050 phosphoglycerol transferase I; Provisional; Region: PRK03776 1197719013051 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1197719013052 hypothetical protein; Provisional; Region: PRK11667 1197719013053 DNA replication protein DnaC; Validated; Region: PRK07952 1197719013054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1197719013055 Walker A motif; other site 1197719013056 ATP binding site [chemical binding]; other site 1197719013057 Walker B motif; other site 1197719013058 primosomal protein DnaI; Provisional; Region: PRK02854 1197719013059 hypothetical protein; Provisional; Region: PRK09917 1197719013060 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1197719013061 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1197719013062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1197719013063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719013064 DNA binding residues [nucleotide binding] 1197719013065 dimerization interface [polypeptide binding]; other site 1197719013066 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1197719013067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1197719013068 DNA binding residues [nucleotide binding] 1197719013069 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1197719013070 putative deacylase active site [active] 1197719013071 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1197719013072 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1197719013073 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1197719013074 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1197719013075 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1197719013076 metal binding site [ion binding]; metal-binding site 1197719013077 active site 1197719013078 I-site; other site 1197719013079 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1197719013080 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1197719013081 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1197719013082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1197719013083 S-adenosylmethionine binding site [chemical binding]; other site 1197719013084 DNA polymerase III subunit psi; Validated; Region: PRK06856 1197719013085 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1197719013086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1197719013087 Coenzyme A binding pocket [chemical binding]; other site 1197719013088 dUMP phosphatase; Provisional; Region: PRK09449 1197719013089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719013090 motif II; other site 1197719013091 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1197719013092 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1197719013093 G1 box; other site 1197719013094 putative GEF interaction site [polypeptide binding]; other site 1197719013095 GTP/Mg2+ binding site [chemical binding]; other site 1197719013096 Switch I region; other site 1197719013097 G2 box; other site 1197719013098 G3 box; other site 1197719013099 Switch II region; other site 1197719013100 G4 box; other site 1197719013101 G5 box; other site 1197719013102 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1197719013103 periplasmic protein; Provisional; Region: PRK10568 1197719013104 BON domain; Region: BON; pfam04972 1197719013105 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1197719013106 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1197719013107 active site 1197719013108 nucleophile elbow; other site 1197719013109 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1197719013110 active site 1197719013111 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1197719013112 hypothetical protein; Provisional; Region: PRK10977 1197719013113 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1197719013114 intersubunit interface [polypeptide binding]; other site 1197719013115 active site 1197719013116 catalytic residue [active] 1197719013117 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1197719013118 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1197719013119 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1197719013120 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1197719013121 phosphopentomutase; Provisional; Region: PRK05362 1197719013122 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1197719013123 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1197719013124 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1197719013125 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1197719013126 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1197719013127 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1197719013128 hypothetical protein; Provisional; Region: PRK11246 1197719013129 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1197719013130 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1197719013131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1197719013132 motif II; other site 1197719013133 DNA repair protein RadA; Region: sms; TIGR00416 1197719013134 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1197719013135 Walker A motif/ATP binding site; other site 1197719013136 ATP binding site [chemical binding]; other site 1197719013137 Walker B motif; other site 1197719013138 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1197719013139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1197719013140 non-specific DNA binding site [nucleotide binding]; other site 1197719013141 salt bridge; other site 1197719013142 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1197719013143 sequence-specific DNA binding site [nucleotide binding]; other site 1197719013144 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1197719013145 active site 1197719013146 (T/H)XGH motif; other site 1197719013147 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1197719013148 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1197719013149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1197719013150 Walker A/P-loop; other site 1197719013151 ATP binding site [chemical binding]; other site 1197719013152 Q-loop/lid; other site 1197719013153 ABC transporter signature motif; other site 1197719013154 Walker B; other site 1197719013155 D-loop; other site 1197719013156 H-loop/switch region; other site 1197719013157 ABC transporter; Region: ABC_tran_2; pfam12848 1197719013158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1197719013159 lytic murein transglycosylase; Provisional; Region: PRK11619 1197719013160 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719013161 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719013162 catalytic residue [active] 1197719013163 Trp operon repressor; Provisional; Region: PRK01381 1197719013164 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1197719013165 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1197719013166 catalytic core [active] 1197719013167 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1197719013168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1197719013169 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1197719013170 hypothetical protein; Provisional; Region: PRK10756 1197719013171 CreA protein; Region: CreA; pfam05981 1197719013172 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1197719013173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719013174 active site 1197719013175 phosphorylation site [posttranslational modification] 1197719013176 intermolecular recognition site; other site 1197719013177 dimerization interface [polypeptide binding]; other site 1197719013178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719013179 DNA binding site [nucleotide binding] 1197719013180 sensory histidine kinase CreC; Provisional; Region: PRK11100 1197719013181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1197719013182 dimerization interface [polypeptide binding]; other site 1197719013183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1197719013184 dimer interface [polypeptide binding]; other site 1197719013185 phosphorylation site [posttranslational modification] 1197719013186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1197719013187 ATP binding site [chemical binding]; other site 1197719013188 Mg2+ binding site [ion binding]; other site 1197719013189 G-X-G motif; other site 1197719013190 Inner membrane protein CreD; Region: CreD; cl01844 1197719013191 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1197719013192 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1197719013193 putative fimbrial protein SthD; Provisional; Region: PRK15293 1197719013194 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 1197719013195 PapC N-terminal domain; Region: PapC_N; pfam13954 1197719013196 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1197719013197 PapC C-terminal domain; Region: PapC_C; pfam13953 1197719013198 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1197719013199 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1197719013200 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1197719013201 putative fimbrial protein SthA; Provisional; Region: PRK15296 1197719013202 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1197719013203 Helix-turn-helix domain; Region: HTH_36; pfam13730 1197719013204 two-component response regulator; Provisional; Region: PRK11173 1197719013205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1197719013206 active site 1197719013207 phosphorylation site [posttranslational modification] 1197719013208 intermolecular recognition site; other site 1197719013209 dimerization interface [polypeptide binding]; other site 1197719013210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1197719013211 DNA binding site [nucleotide binding] 1197719013212 putative RNA methyltransferase; Provisional; Region: PRK10433 1197719013213 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1197719013214 Integrase core domain; Region: rve_3; pfam13683 1197719013215 IncFII RepA protein family; Region: IncFII_repA; cl11495 1197719013216 IncFII RepA protein family; Region: IncFII_repA; cl11495 1197719013217 replication protein; Provisional; Region: PRK13702 1197719013218 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1197719013219 TraX protein; Region: TraX; cl05434 1197719013220 TraX protein; Region: TraX; cl05434 1197719013221 TraX protein; Region: TraX; cl05434 1197719013222 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1197719013223 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 1197719013224 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1197719013225 AAA domain; Region: AAA_30; pfam13604 1197719013226 Family description; Region: UvrD_C_2; pfam13538 1197719013227 DNA helicase TraI; Region: TraI; pfam07057 1197719013228 conjugal transfer protein TraD; Provisional; Region: PRK13700 1197719013229 F sex factor protein N terminal; Region: TraD_N; pfam12615 1197719013230 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1197719013231 Walker A motif; other site 1197719013232 ATP binding site [chemical binding]; other site 1197719013233 Walker B motif; other site 1197719013234 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 1197719013235 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 1197719013236 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 1197719013237 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 1197719013238 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1197719013239 type-F conjugative transfer system pilin assembly protein TraF; Region: TraF; TIGR02739 1197719013240 F plasmid transfer operon protein; Region: TraF; pfam13728 1197719013241 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 1197719013242 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 1197719013243 TraU protein; Region: TraU; cl06067 1197719013244 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 1197719013245 type-F conjugative transfer system protein TrbI; Region: TrbI_Ftype; TIGR02744 1197719013246 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 1197719013247 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1197719013248 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 1197719013249 TraP protein; Region: TraP; cl11652 1197719013250 TraP protein; Region: TraP; cl11652 1197719013251 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1197719013252 G1 box; other site 1197719013253 GTP/Mg2+ binding site [chemical binding]; other site 1197719013254 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1197719013255 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 1197719013256 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1197719013257 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 1197719013258 TraK protein; Region: TraK; pfam06586 1197719013259 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 1197719013260 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 1197719013261 TraA; Region: TraA; cl11503 1197719013262 TraM protein; Region: Tra_M; cl11621 1197719013263 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1197719013264 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1197719013265 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1197719013266 catalytic residue [active] 1197719013267 Antirestriction protein; Region: Antirestrict; pfam03230 1197719013268 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1197719013269 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 1197719013270 Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290 1197719013271 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1197719013272 ParB-like nuclease domain; Region: ParB; smart00470 1197719013273 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1197719013274 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1197719013275 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1197719013276 dimer interface [polypeptide binding]; other site 1197719013277 ssDNA binding site [nucleotide binding]; other site 1197719013278 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1197719013279 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 1197719013280 Antirestriction protein (ArdA); Region: ArdA; cl01953 1197719013281 Antirestriction protein (ArdA); Region: ArdA; cl01953 1197719013282 Antirestriction protein; Region: Antirestrict; pfam03230 1197719013283 Pab87 octamerisation domain; Region: Pab87_oct; pfam13969 1197719013284 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1197719013285 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1197719013286 putative methylase; Provisional; Region: PRK13699 1197719013287 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1197719013288 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1197719013289 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1197719013290 Catalytic site [active] 1197719013291 impB/mucB/samB family; Region: IMS; pfam00817 1197719013292 active site 1197719013293 Y-family of DNA polymerases; Region: PolY; cl12025 1197719013294 DNA binding site [nucleotide binding] 1197719013295 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1197719013296 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1197719013297 ParB-like nuclease domain; Region: ParBc; pfam02195 1197719013298 ParB family; Region: ParB; pfam08775 1197719013299 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1197719013300 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1197719013301 P-loop; other site 1197719013302 Magnesium ion binding site [ion binding]; other site 1197719013303 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1197719013304 Magnesium ion binding site [ion binding]; other site 1197719013305 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1197719013306 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719013307 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 1197719013308 dimer interface [polypeptide binding]; other site 1197719013309 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 1197719013310 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1197719013311 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1197719013312 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1197719013313 active site 1197719013314 catalytic residues [active] 1197719013315 DNA binding site [nucleotide binding] 1197719013316 Int/Topo IB signature motif; other site 1197719013317 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 1197719013318 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 1197719013319 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1197719013320 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1197719013321 oligomeric interface; other site 1197719013322 putative active site [active] 1197719013323 homodimer interface [polypeptide binding]; other site 1197719013324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1197719013325 DNA binding site [nucleotide binding] 1197719013326 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1197719013327 hypothetical protein; Provisional; Region: PRK09945 1197719013328 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1197719013329 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1197719013330 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1197719013331 Vi polysaccharide biosynthesis protein TviA; Provisional; Region: PRK15183 1197719013332 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1197719013333 putative transposase OrfB; Reviewed; Region: PHA02517 1197719013334 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1197719013335 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1197719013336 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1197719013337 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1197719013338 active site 1197719013339 catalytic residues [active] 1197719013340 DNA binding site [nucleotide binding] 1197719013341 Int/Topo IB signature motif; other site 1197719013342 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1197719013343 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1197719013344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1197719013345 DNA binding residues [nucleotide binding] 1197719013346 dimerization interface [polypeptide binding]; other site 1197719013347 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1197719013348 catalytic residue [active] 1197719013349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1197719013350 DNA binding site [nucleotide binding] 1197719013351 Integrase core domain; Region: rve; pfam00665 1197719013352 Integrase core domain; Region: rve_2; pfam13333 1197719013353 Transposase; Region: HTH_Tnp_1; cl17663 1197719013354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1197719013355 Integrase core domain; Region: rve; pfam00665 1197719013356 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1197719013357 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1197719013358 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740