-- dump date 20140620_051933 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1271864000001 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1271864000002 FAD binding domain; Region: FAD_binding_4; pfam01565 1271864000003 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1271864000004 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1271864000005 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1271864000006 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1271864000007 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1271864000008 pantothenate kinase; Provisional; Region: PRK05439 1271864000009 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1271864000010 ATP-binding site [chemical binding]; other site 1271864000011 CoA-binding site [chemical binding]; other site 1271864000012 Mg2+-binding site [ion binding]; other site 1271864000013 elongation factor Tu; Reviewed; Region: PRK00049 1271864000014 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1271864000015 G1 box; other site 1271864000016 GEF interaction site [polypeptide binding]; other site 1271864000017 GTP/Mg2+ binding site [chemical binding]; other site 1271864000018 Switch I region; other site 1271864000019 G2 box; other site 1271864000020 G3 box; other site 1271864000021 Switch II region; other site 1271864000022 G4 box; other site 1271864000023 G5 box; other site 1271864000024 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1271864000025 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1271864000026 Antibiotic Binding Site [chemical binding]; other site 1271864000027 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1271864000028 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1271864000029 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1271864000030 putative homodimer interface [polypeptide binding]; other site 1271864000031 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1271864000032 heterodimer interface [polypeptide binding]; other site 1271864000033 homodimer interface [polypeptide binding]; other site 1271864000034 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1271864000035 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1271864000036 23S rRNA interface [nucleotide binding]; other site 1271864000037 L7/L12 interface [polypeptide binding]; other site 1271864000038 putative thiostrepton binding site; other site 1271864000039 L25 interface [polypeptide binding]; other site 1271864000040 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1271864000041 mRNA/rRNA interface [nucleotide binding]; other site 1271864000042 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1271864000043 23S rRNA interface [nucleotide binding]; other site 1271864000044 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1271864000045 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1271864000046 core dimer interface [polypeptide binding]; other site 1271864000047 peripheral dimer interface [polypeptide binding]; other site 1271864000048 L10 interface [polypeptide binding]; other site 1271864000049 L11 interface [polypeptide binding]; other site 1271864000050 putative EF-Tu interaction site [polypeptide binding]; other site 1271864000051 putative EF-G interaction site [polypeptide binding]; other site 1271864000052 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1271864000053 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1271864000054 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1271864000055 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1271864000056 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1271864000057 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1271864000058 RPB3 interaction site [polypeptide binding]; other site 1271864000059 RPB1 interaction site [polypeptide binding]; other site 1271864000060 RPB11 interaction site [polypeptide binding]; other site 1271864000061 RPB10 interaction site [polypeptide binding]; other site 1271864000062 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1271864000063 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1271864000064 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1271864000065 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1271864000066 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1271864000067 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1271864000068 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1271864000069 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1271864000070 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1271864000071 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1271864000072 DNA binding site [nucleotide binding] 1271864000073 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1271864000074 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1271864000075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864000076 FeS/SAM binding site; other site 1271864000077 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1271864000078 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1271864000079 ThiS interaction site; other site 1271864000080 putative active site [active] 1271864000081 tetramer interface [polypeptide binding]; other site 1271864000082 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1271864000083 thiS-thiF/thiG interaction site; other site 1271864000084 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1271864000085 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1271864000086 ATP binding site [chemical binding]; other site 1271864000087 substrate interface [chemical binding]; other site 1271864000088 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1271864000089 thiamine phosphate binding site [chemical binding]; other site 1271864000090 active site 1271864000091 pyrophosphate binding site [ion binding]; other site 1271864000092 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1271864000093 ThiC-associated domain; Region: ThiC-associated; pfam13667 1271864000094 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1271864000095 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1271864000096 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1271864000097 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1271864000098 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1271864000099 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1271864000100 putative NADH binding site [chemical binding]; other site 1271864000101 putative active site [active] 1271864000102 nudix motif; other site 1271864000103 putative metal binding site [ion binding]; other site 1271864000104 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1271864000105 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1271864000106 substrate binding site [chemical binding]; other site 1271864000107 active site 1271864000108 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1271864000109 Active_site [active] 1271864000110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1271864000111 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1271864000112 IHF dimer interface [polypeptide binding]; other site 1271864000113 IHF - DNA interface [nucleotide binding]; other site 1271864000114 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1271864000115 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1271864000116 dimer interface [polypeptide binding]; other site 1271864000117 sensor protein ZraS; Provisional; Region: PRK10364 1271864000118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864000119 dimer interface [polypeptide binding]; other site 1271864000120 phosphorylation site [posttranslational modification] 1271864000121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864000122 ATP binding site [chemical binding]; other site 1271864000123 Mg2+ binding site [ion binding]; other site 1271864000124 G-X-G motif; other site 1271864000125 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1271864000126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864000127 active site 1271864000128 phosphorylation site [posttranslational modification] 1271864000129 intermolecular recognition site; other site 1271864000130 dimerization interface [polypeptide binding]; other site 1271864000131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864000132 Walker A motif; other site 1271864000133 ATP binding site [chemical binding]; other site 1271864000134 Walker B motif; other site 1271864000135 arginine finger; other site 1271864000136 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1271864000137 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1271864000138 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1271864000139 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1271864000140 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1271864000141 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1271864000142 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1271864000143 purine monophosphate binding site [chemical binding]; other site 1271864000144 dimer interface [polypeptide binding]; other site 1271864000145 putative catalytic residues [active] 1271864000146 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1271864000147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1271864000148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864000149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1271864000150 Coenzyme A binding pocket [chemical binding]; other site 1271864000151 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1271864000152 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1271864000153 proposed active site lysine [active] 1271864000154 conserved cys residue [active] 1271864000155 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1271864000156 malate synthase A; Region: malate_syn_A; TIGR01344 1271864000157 active site 1271864000158 isocitrate lyase; Provisional; Region: PRK15063 1271864000159 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1271864000160 tetramer interface [polypeptide binding]; other site 1271864000161 active site 1271864000162 Mg2+/Mn2+ binding site [ion binding]; other site 1271864000163 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1271864000164 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1271864000165 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1271864000166 transcriptional repressor IclR; Provisional; Region: PRK11569 1271864000167 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1271864000168 Bacterial transcriptional regulator; Region: IclR; pfam01614 1271864000169 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1271864000170 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1271864000171 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1271864000172 substrate binding pocket [chemical binding]; other site 1271864000173 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1271864000174 B12 binding site [chemical binding]; other site 1271864000175 cobalt ligand [ion binding]; other site 1271864000176 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1271864000177 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1271864000178 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1271864000179 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1271864000180 active site pocket [active] 1271864000181 oxyanion hole [active] 1271864000182 catalytic triad [active] 1271864000183 active site nucleophile [active] 1271864000184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1271864000185 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1271864000186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864000187 RNA binding surface [nucleotide binding]; other site 1271864000188 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1271864000189 probable active site [active] 1271864000190 hypothetical protein; Provisional; Region: PRK10515 1271864000191 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1271864000192 Sodium Bile acid symporter family; Region: SBF; pfam01758 1271864000193 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1271864000194 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1271864000195 trimer interface [polypeptide binding]; other site 1271864000196 active site 1271864000197 substrate binding site [chemical binding]; other site 1271864000198 CoA binding site [chemical binding]; other site 1271864000199 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 1271864000200 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1271864000201 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1271864000202 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1271864000203 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1271864000204 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 1271864000205 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1271864000206 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1271864000207 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1271864000208 Ligand binding site; other site 1271864000209 Putative Catalytic site; other site 1271864000210 DXD motif; other site 1271864000211 Predicted membrane protein [Function unknown]; Region: COG2246 1271864000212 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1271864000213 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1271864000214 Phage protein D [General function prediction only]; Region: COG3500 1271864000215 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1271864000216 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1271864000217 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1271864000218 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1271864000219 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1271864000220 Phage tail tube protein FII [General function prediction only]; Region: COG3498 1271864000221 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1271864000222 Gp37 protein; Region: Gp37; pfam09646 1271864000223 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1271864000224 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864000225 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864000226 catalytic residue [active] 1271864000227 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1271864000228 Mor transcription activator family; Region: Mor; pfam08765 1271864000229 aspartate kinase III; Validated; Region: PRK09084 1271864000230 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1271864000231 nucleotide binding site [chemical binding]; other site 1271864000232 substrate binding site [chemical binding]; other site 1271864000233 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1271864000234 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1271864000235 dimer interface [polypeptide binding]; other site 1271864000236 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1271864000237 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1271864000238 active site 1271864000239 dimer interface [polypeptide binding]; other site 1271864000240 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1271864000241 dimer interface [polypeptide binding]; other site 1271864000242 active site 1271864000243 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1271864000244 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1271864000245 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1271864000246 Predicted membrane protein [Function unknown]; Region: COG3223 1271864000247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1271864000248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864000249 dimer interface [polypeptide binding]; other site 1271864000250 conserved gate region; other site 1271864000251 putative PBP binding loops; other site 1271864000252 ABC-ATPase subunit interface; other site 1271864000253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864000254 dimer interface [polypeptide binding]; other site 1271864000255 conserved gate region; other site 1271864000256 putative PBP binding loops; other site 1271864000257 ABC-ATPase subunit interface; other site 1271864000258 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1271864000259 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1271864000260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1271864000261 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1271864000262 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1271864000263 Walker A/P-loop; other site 1271864000264 ATP binding site [chemical binding]; other site 1271864000265 Q-loop/lid; other site 1271864000266 ABC transporter signature motif; other site 1271864000267 Walker B; other site 1271864000268 D-loop; other site 1271864000269 H-loop/switch region; other site 1271864000270 TOBE domain; Region: TOBE_2; pfam08402 1271864000271 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1271864000272 trimer interface; other site 1271864000273 sugar binding site [chemical binding]; other site 1271864000274 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1271864000275 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1271864000276 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1271864000277 UbiA prenyltransferase family; Region: UbiA; pfam01040 1271864000278 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1271864000279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1271864000280 putative acyl-acceptor binding pocket; other site 1271864000281 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1271864000282 LexA repressor; Validated; Region: PRK00215 1271864000283 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1271864000284 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1271864000285 Catalytic site [active] 1271864000286 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1271864000287 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1271864000288 hypothetical protein; Provisional; Region: PRK10428 1271864000289 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1271864000290 metal binding site 2 [ion binding]; metal-binding site 1271864000291 putative DNA binding helix; other site 1271864000292 metal binding site 1 [ion binding]; metal-binding site 1271864000293 dimer interface [polypeptide binding]; other site 1271864000294 structural Zn2+ binding site [ion binding]; other site 1271864000295 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1271864000296 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1271864000297 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1271864000298 FMN binding site [chemical binding]; other site 1271864000299 active site 1271864000300 catalytic residues [active] 1271864000301 substrate binding site [chemical binding]; other site 1271864000302 phage shock protein G; Reviewed; Region: pspG; PRK09459 1271864000303 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1271864000304 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1271864000305 NADP binding site [chemical binding]; other site 1271864000306 dimer interface [polypeptide binding]; other site 1271864000307 replicative DNA helicase; Provisional; Region: PRK08006 1271864000308 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1271864000309 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1271864000310 Walker A motif; other site 1271864000311 ATP binding site [chemical binding]; other site 1271864000312 Walker B motif; other site 1271864000313 DNA binding loops [nucleotide binding] 1271864000314 alanine racemase; Reviewed; Region: alr; PRK00053 1271864000315 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1271864000316 active site 1271864000317 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1271864000318 substrate binding site [chemical binding]; other site 1271864000319 catalytic residues [active] 1271864000320 dimer interface [polypeptide binding]; other site 1271864000321 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1271864000322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864000323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864000324 homodimer interface [polypeptide binding]; other site 1271864000325 catalytic residue [active] 1271864000326 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1271864000327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864000328 active site 1271864000329 motif I; other site 1271864000330 motif II; other site 1271864000331 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1271864000332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1271864000333 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1271864000334 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1271864000335 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1271864000336 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1271864000337 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1271864000338 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1271864000339 dimer interface [polypeptide binding]; other site 1271864000340 ssDNA binding site [nucleotide binding]; other site 1271864000341 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1271864000342 hypothetical protein; Validated; Region: PRK09039 1271864000343 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1271864000344 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1271864000345 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1271864000346 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864000347 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864000348 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864000349 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000350 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000351 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000352 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000353 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000354 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000355 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864000356 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000357 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000358 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000359 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000360 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864000361 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000362 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000363 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864000364 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000365 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000366 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000367 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000368 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864000369 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000370 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000371 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000372 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000373 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000374 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000375 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1271864000376 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000377 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000378 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000379 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000380 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000381 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000382 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864000383 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000384 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 1271864000385 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000386 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000387 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864000388 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1271864000389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864000390 Walker A/P-loop; other site 1271864000391 ATP binding site [chemical binding]; other site 1271864000392 Q-loop/lid; other site 1271864000393 ABC transporter signature motif; other site 1271864000394 Walker B; other site 1271864000395 D-loop; other site 1271864000396 H-loop/switch region; other site 1271864000397 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1271864000398 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1271864000399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864000400 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1271864000401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864000402 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1271864000403 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1271864000404 DNA binding residues [nucleotide binding] 1271864000405 dimer interface [polypeptide binding]; other site 1271864000406 [2Fe-2S] cluster binding site [ion binding]; other site 1271864000407 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1271864000408 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1271864000409 putative C-terminal domain interface [polypeptide binding]; other site 1271864000410 putative GSH binding site (G-site) [chemical binding]; other site 1271864000411 putative dimer interface [polypeptide binding]; other site 1271864000412 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1271864000413 putative N-terminal domain interface [polypeptide binding]; other site 1271864000414 putative dimer interface [polypeptide binding]; other site 1271864000415 putative substrate binding pocket (H-site) [chemical binding]; other site 1271864000416 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1271864000417 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1271864000418 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1271864000419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864000420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864000421 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1271864000422 putative dimerization interface [polypeptide binding]; other site 1271864000423 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1271864000424 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1271864000425 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1271864000426 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1271864000427 Na binding site [ion binding]; other site 1271864000428 Predicted membrane protein [Function unknown]; Region: COG3162 1271864000429 acetyl-CoA synthetase; Provisional; Region: PRK00174 1271864000430 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1271864000431 active site 1271864000432 CoA binding site [chemical binding]; other site 1271864000433 acyl-activating enzyme (AAE) consensus motif; other site 1271864000434 AMP binding site [chemical binding]; other site 1271864000435 acetate binding site [chemical binding]; other site 1271864000436 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1271864000437 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1271864000438 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1271864000439 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1271864000440 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1271864000441 heme lyase subunit NrfE; Provisional; Region: PRK10369 1271864000442 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1271864000443 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1271864000444 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1271864000445 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1271864000446 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864000447 Sel1-like repeats; Region: SEL1; smart00671 1271864000448 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864000449 molybdopterin cofactor binding site; other site 1271864000450 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1271864000451 molybdopterin cofactor binding site; other site 1271864000452 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864000453 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1271864000454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864000455 Coenzyme A binding pocket [chemical binding]; other site 1271864000456 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1271864000457 dimer interface [polypeptide binding]; other site 1271864000458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1271864000459 hypothetical protein; Provisional; Region: PRK10220 1271864000460 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1271864000461 PhnA protein; Region: PhnA; pfam03831 1271864000462 proline/glycine betaine transporter; Provisional; Region: PRK10642 1271864000463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864000464 putative substrate translocation pore; other site 1271864000465 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1271864000466 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1271864000467 HAMP domain; Region: HAMP; pfam00672 1271864000468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864000469 dimer interface [polypeptide binding]; other site 1271864000470 phosphorylation site [posttranslational modification] 1271864000471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864000472 ATP binding site [chemical binding]; other site 1271864000473 Mg2+ binding site [ion binding]; other site 1271864000474 G-X-G motif; other site 1271864000475 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1271864000476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864000477 active site 1271864000478 phosphorylation site [posttranslational modification] 1271864000479 intermolecular recognition site; other site 1271864000480 dimerization interface [polypeptide binding]; other site 1271864000481 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864000482 DNA binding site [nucleotide binding] 1271864000483 putative metal dependent hydrolase; Provisional; Region: PRK11598 1271864000484 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1271864000485 Sulfatase; Region: Sulfatase; pfam00884 1271864000486 arginine:agmatin antiporter; Provisional; Region: PRK10644 1271864000487 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1271864000488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864000489 arginine decarboxylase; Provisional; Region: PRK15029 1271864000490 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1271864000491 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1271864000492 homodimer interface [polypeptide binding]; other site 1271864000493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864000494 catalytic residue [active] 1271864000495 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1271864000496 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1271864000497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864000498 alpha-galactosidase; Provisional; Region: PRK15076 1271864000499 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1271864000500 NAD binding site [chemical binding]; other site 1271864000501 sugar binding site [chemical binding]; other site 1271864000502 divalent metal binding site [ion binding]; other site 1271864000503 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1271864000504 dimer interface [polypeptide binding]; other site 1271864000505 melibiose:sodium symporter; Provisional; Region: PRK10429 1271864000506 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1271864000507 fumarate hydratase; Provisional; Region: PRK15389 1271864000508 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1271864000509 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1271864000510 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1271864000511 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1271864000512 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1271864000513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864000514 active site 1271864000515 phosphorylation site [posttranslational modification] 1271864000516 intermolecular recognition site; other site 1271864000517 dimerization interface [polypeptide binding]; other site 1271864000518 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1271864000519 PAS domain; Region: PAS; smart00091 1271864000520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864000521 ATP binding site [chemical binding]; other site 1271864000522 Mg2+ binding site [ion binding]; other site 1271864000523 G-X-G motif; other site 1271864000524 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1271864000525 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1271864000526 putative [Fe4-S4] binding site [ion binding]; other site 1271864000527 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864000528 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1271864000529 putative molybdopterin cofactor binding site; other site 1271864000530 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1271864000531 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1271864000532 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1271864000533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1271864000534 SdiA-regulated; Region: SdiA-regulated; cd09971 1271864000535 putative active site [active] 1271864000536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1271864000537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864000538 DNA binding residues [nucleotide binding] 1271864000539 dimerization interface [polypeptide binding]; other site 1271864000540 AraC family transcriptional regulator; Provisional; Region: PRK15186 1271864000541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864000542 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1271864000543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1271864000544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1271864000545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1271864000546 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1271864000547 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1271864000548 active site 1271864000549 putative transcriptional regulator; Provisional; Region: PRK11640 1271864000550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864000551 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1271864000552 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1271864000553 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1271864000554 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1271864000555 DsbD alpha interface [polypeptide binding]; other site 1271864000556 catalytic residues [active] 1271864000557 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1271864000558 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1271864000559 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1271864000560 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1271864000561 Aspartase; Region: Aspartase; cd01357 1271864000562 active sites [active] 1271864000563 tetramer interface [polypeptide binding]; other site 1271864000564 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1271864000565 putative transporter; Provisional; Region: PRK11021 1271864000566 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1271864000567 oligomerisation interface [polypeptide binding]; other site 1271864000568 mobile loop; other site 1271864000569 roof hairpin; other site 1271864000570 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1271864000571 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1271864000572 ring oligomerisation interface [polypeptide binding]; other site 1271864000573 ATP/Mg binding site [chemical binding]; other site 1271864000574 stacking interactions; other site 1271864000575 hinge regions; other site 1271864000576 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1271864000577 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1271864000578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864000579 FeS/SAM binding site; other site 1271864000580 elongation factor P; Validated; Region: PRK00529 1271864000581 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1271864000582 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1271864000583 RNA binding site [nucleotide binding]; other site 1271864000584 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1271864000585 RNA binding site [nucleotide binding]; other site 1271864000586 Predicted small secreted protein [Function unknown]; Region: COG5510 1271864000587 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1271864000588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1271864000589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864000590 DNA binding residues [nucleotide binding] 1271864000591 dimerization interface [polypeptide binding]; other site 1271864000592 multidrug efflux system protein; Provisional; Region: PRK11431 1271864000593 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1271864000594 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1271864000595 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1271864000596 Iron-sulfur protein interface; other site 1271864000597 proximal quinone binding site [chemical binding]; other site 1271864000598 C-subunit interface; other site 1271864000599 distal quinone binding site; other site 1271864000600 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1271864000601 D-subunit interface [polypeptide binding]; other site 1271864000602 Iron-sulfur protein interface; other site 1271864000603 proximal quinone binding site [chemical binding]; other site 1271864000604 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1271864000605 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1271864000606 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1271864000607 L-aspartate oxidase; Provisional; Region: PRK06175 1271864000608 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1271864000609 poxB regulator PoxA; Provisional; Region: PRK09350 1271864000610 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1271864000611 motif 1; other site 1271864000612 dimer interface [polypeptide binding]; other site 1271864000613 active site 1271864000614 motif 2; other site 1271864000615 motif 3; other site 1271864000616 inner membrane transporter YjeM; Provisional; Region: PRK15238 1271864000617 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1271864000618 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1271864000619 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864000620 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1271864000621 GTPase RsgA; Reviewed; Region: PRK12288 1271864000622 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1271864000623 RNA binding site [nucleotide binding]; other site 1271864000624 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1271864000625 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1271864000626 GTP/Mg2+ binding site [chemical binding]; other site 1271864000627 G4 box; other site 1271864000628 G5 box; other site 1271864000629 G1 box; other site 1271864000630 Switch I region; other site 1271864000631 G2 box; other site 1271864000632 G3 box; other site 1271864000633 Switch II region; other site 1271864000634 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1271864000635 catalytic site [active] 1271864000636 putative active site [active] 1271864000637 putative substrate binding site [chemical binding]; other site 1271864000638 dimer interface [polypeptide binding]; other site 1271864000639 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1271864000640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864000641 substrate binding pocket [chemical binding]; other site 1271864000642 membrane-bound complex binding site; other site 1271864000643 hinge residues; other site 1271864000644 epoxyqueuosine reductase; Region: TIGR00276 1271864000645 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1271864000646 putative carbohydrate kinase; Provisional; Region: PRK10565 1271864000647 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1271864000648 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1271864000649 putative substrate binding site [chemical binding]; other site 1271864000650 putative ATP binding site [chemical binding]; other site 1271864000651 ADP-binding protein; Provisional; Region: PRK10646 1271864000652 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1271864000653 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1271864000654 active site 1271864000655 metal binding site [ion binding]; metal-binding site 1271864000656 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1271864000657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864000658 ATP binding site [chemical binding]; other site 1271864000659 Mg2+ binding site [ion binding]; other site 1271864000660 G-X-G motif; other site 1271864000661 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1271864000662 ATP binding site [chemical binding]; other site 1271864000663 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1271864000664 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1271864000665 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1271864000666 bacterial Hfq-like; Region: Hfq; cd01716 1271864000667 hexamer interface [polypeptide binding]; other site 1271864000668 Sm1 motif; other site 1271864000669 RNA binding site [nucleotide binding]; other site 1271864000670 Sm2 motif; other site 1271864000671 GTPase HflX; Provisional; Region: PRK11058 1271864000672 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1271864000673 HflX GTPase family; Region: HflX; cd01878 1271864000674 G1 box; other site 1271864000675 GTP/Mg2+ binding site [chemical binding]; other site 1271864000676 Switch I region; other site 1271864000677 G2 box; other site 1271864000678 G3 box; other site 1271864000679 Switch II region; other site 1271864000680 G4 box; other site 1271864000681 G5 box; other site 1271864000682 FtsH protease regulator HflK; Provisional; Region: PRK10930 1271864000683 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1271864000684 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1271864000685 FtsH protease regulator HflC; Provisional; Region: PRK11029 1271864000686 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1271864000687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1271864000688 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1271864000689 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1271864000690 GDP-binding site [chemical binding]; other site 1271864000691 ACT binding site; other site 1271864000692 IMP binding site; other site 1271864000693 Predicted transcriptional regulator [Transcription]; Region: COG1959 1271864000694 transcriptional repressor NsrR; Provisional; Region: PRK11014 1271864000695 exoribonuclease R; Provisional; Region: PRK11642 1271864000696 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1271864000697 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1271864000698 RNB domain; Region: RNB; pfam00773 1271864000699 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1271864000700 RNA binding site [nucleotide binding]; other site 1271864000701 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1271864000702 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1271864000703 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1271864000704 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1271864000705 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1271864000706 Ion channel; Region: Ion_trans_2; pfam07885 1271864000707 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1271864000708 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1271864000709 Predicted membrane protein [Function unknown]; Region: COG3766 1271864000710 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1271864000711 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1271864000712 Predicted integral membrane protein [Function unknown]; Region: COG5463 1271864000713 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1271864000714 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1271864000715 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1271864000716 FAD binding site [chemical binding]; other site 1271864000717 substrate binding site [chemical binding]; other site 1271864000718 catalytic residues [active] 1271864000719 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864000720 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1271864000721 esterase; Provisional; Region: PRK10566 1271864000722 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1271864000723 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1271864000724 transcriptional repressor UlaR; Provisional; Region: PRK13509 1271864000725 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1271864000726 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864000727 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1271864000728 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1271864000729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1271864000730 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1271864000731 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1271864000732 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864000733 active site 1271864000734 phosphorylation site [posttranslational modification] 1271864000735 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1271864000736 active site 1271864000737 dimer interface [polypeptide binding]; other site 1271864000738 magnesium binding site [ion binding]; other site 1271864000739 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1271864000740 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1271864000741 AP (apurinic/apyrimidinic) site pocket; other site 1271864000742 DNA interaction; other site 1271864000743 Metal-binding active site; metal-binding site 1271864000744 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1271864000745 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1271864000746 intersubunit interface [polypeptide binding]; other site 1271864000747 active site 1271864000748 Zn2+ binding site [ion binding]; other site 1271864000749 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864000750 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1271864000751 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1271864000752 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1271864000753 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1271864000754 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1271864000755 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1271864000756 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1271864000757 EamA-like transporter family; Region: EamA; pfam00892 1271864000758 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1271864000759 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1271864000760 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1271864000761 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1271864000762 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1271864000763 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1271864000764 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1271864000765 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1271864000766 Hemerythrin-like domain; Region: Hr-like; cd12108 1271864000767 Fe binding site [ion binding]; other site 1271864000768 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1271864000769 EamA-like transporter family; Region: EamA; pfam00892 1271864000770 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1271864000771 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1271864000772 NADP binding site [chemical binding]; other site 1271864000773 Predicted transcriptional regulators [Transcription]; Region: COG1733 1271864000774 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1271864000775 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1271864000776 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1271864000777 active site 1271864000778 metal binding site [ion binding]; metal-binding site 1271864000779 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1271864000780 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1271864000781 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1271864000782 active site 1271864000783 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1271864000784 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1271864000785 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1271864000786 Domain of unknown function DUF21; Region: DUF21; pfam01595 1271864000787 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1271864000788 Transporter associated domain; Region: CorC_HlyC; smart01091 1271864000789 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1271864000790 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1271864000791 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1271864000792 Surface antigen; Region: Bac_surface_Ag; pfam01103 1271864000793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1271864000794 Family of unknown function (DUF490); Region: DUF490; pfam04357 1271864000795 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1271864000796 putative active site pocket [active] 1271864000797 dimerization interface [polypeptide binding]; other site 1271864000798 putative catalytic residue [active] 1271864000799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864000800 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864000801 putative substrate translocation pore; other site 1271864000802 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1271864000803 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1271864000804 active site 1271864000805 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1271864000806 dimer interface [polypeptide binding]; other site 1271864000807 substrate binding site [chemical binding]; other site 1271864000808 metal binding sites [ion binding]; metal-binding site 1271864000809 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1271864000810 AMP binding site [chemical binding]; other site 1271864000811 metal binding site [ion binding]; metal-binding site 1271864000812 active site 1271864000813 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1271864000814 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1271864000815 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1271864000816 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1271864000817 hypothetical protein; Provisional; Region: PRK05255 1271864000818 peptidase PmbA; Provisional; Region: PRK11040 1271864000819 cytochrome b562; Provisional; Region: PRK15058 1271864000820 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1271864000821 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1271864000822 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1271864000823 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1271864000824 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1271864000825 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1271864000826 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1271864000827 active site 1271864000828 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1271864000829 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1271864000830 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1271864000831 HTH domain; Region: HTH_11; pfam08279 1271864000832 Mga helix-turn-helix domain; Region: Mga; pfam05043 1271864000833 PRD domain; Region: PRD; pfam00874 1271864000834 PRD domain; Region: PRD; pfam00874 1271864000835 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1271864000836 active site 1271864000837 P-loop; other site 1271864000838 phosphorylation site [posttranslational modification] 1271864000839 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864000840 active site 1271864000841 phosphorylation site [posttranslational modification] 1271864000842 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1271864000843 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1271864000844 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1271864000845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864000846 FeS/SAM binding site; other site 1271864000847 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1271864000848 ATP cone domain; Region: ATP-cone; pfam03477 1271864000849 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1271864000850 effector binding site; other site 1271864000851 active site 1271864000852 Zn binding site [ion binding]; other site 1271864000853 glycine loop; other site 1271864000854 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1271864000855 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1271864000856 Ca binding site [ion binding]; other site 1271864000857 active site 1271864000858 catalytic site [active] 1271864000859 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1271864000860 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1271864000861 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1271864000862 active site turn [active] 1271864000863 phosphorylation site [posttranslational modification] 1271864000864 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1271864000865 trehalose repressor; Provisional; Region: treR; PRK09492 1271864000866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864000867 DNA binding site [nucleotide binding] 1271864000868 domain linker motif; other site 1271864000869 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1271864000870 dimerization interface [polypeptide binding]; other site 1271864000871 ligand binding site [chemical binding]; other site 1271864000872 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1271864000873 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1271864000874 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1271864000875 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1271864000876 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1271864000877 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1271864000878 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1271864000879 Transposase; Region: HTH_Tnp_1; cl17663 1271864000880 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1271864000881 homotrimer interaction site [polypeptide binding]; other site 1271864000882 putative active site [active] 1271864000883 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1271864000884 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1271864000885 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1271864000886 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1271864000887 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1271864000888 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1271864000889 Arginine repressor [Transcription]; Region: ArgR; COG1438 1271864000890 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1271864000891 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1271864000892 Predicted membrane protein [Function unknown]; Region: COG1288 1271864000893 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1271864000894 ornithine carbamoyltransferase; Validated; Region: PRK02102 1271864000895 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1271864000896 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1271864000897 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1271864000898 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1271864000899 putative substrate binding site [chemical binding]; other site 1271864000900 nucleotide binding site [chemical binding]; other site 1271864000901 nucleotide binding site [chemical binding]; other site 1271864000902 homodimer interface [polypeptide binding]; other site 1271864000903 arginine deiminase; Provisional; Region: PRK01388 1271864000904 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1271864000905 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1271864000906 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1271864000907 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1271864000908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1271864000909 RNase E inhibitor protein; Provisional; Region: PRK11191 1271864000910 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1271864000911 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1271864000912 active site 1271864000913 dinuclear metal binding site [ion binding]; other site 1271864000914 dimerization interface [polypeptide binding]; other site 1271864000915 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1271864000916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1271864000917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864000918 Coenzyme A binding pocket [chemical binding]; other site 1271864000919 Predicted membrane protein [Function unknown]; Region: COG4269 1271864000920 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1271864000921 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1271864000922 HIGH motif; other site 1271864000923 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1271864000924 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1271864000925 active site 1271864000926 KMSKS motif; other site 1271864000927 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1271864000928 tRNA binding surface [nucleotide binding]; other site 1271864000929 anticodon binding site; other site 1271864000930 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1271864000931 DNA polymerase III subunit chi; Validated; Region: PRK05728 1271864000932 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1271864000933 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1271864000934 interface (dimer of trimers) [polypeptide binding]; other site 1271864000935 Substrate-binding/catalytic site; other site 1271864000936 Zn-binding sites [ion binding]; other site 1271864000937 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1271864000938 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1271864000939 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1271864000940 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1271864000941 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1271864000942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864000943 DNA binding site [nucleotide binding] 1271864000944 domain linker motif; other site 1271864000945 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1271864000946 putative dimerization interface [polypeptide binding]; other site 1271864000947 putative ligand binding site [chemical binding]; other site 1271864000948 gluconate transporter; Region: gntP; TIGR00791 1271864000949 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1271864000950 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1271864000951 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1271864000952 NADP binding site [chemical binding]; other site 1271864000953 homodimer interface [polypeptide binding]; other site 1271864000954 active site 1271864000955 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1271864000956 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1271864000957 putative NAD(P) binding site [chemical binding]; other site 1271864000958 catalytic Zn binding site [ion binding]; other site 1271864000959 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1271864000960 ATP-binding site [chemical binding]; other site 1271864000961 Gluconate-6-phosphate binding site [chemical binding]; other site 1271864000962 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1271864000963 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1271864000964 putative NAD(P) binding site [chemical binding]; other site 1271864000965 putative substrate binding site [chemical binding]; other site 1271864000966 catalytic Zn binding site [ion binding]; other site 1271864000967 structural Zn binding site [ion binding]; other site 1271864000968 dimer interface [polypeptide binding]; other site 1271864000969 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1271864000970 HNH endonuclease; Region: HNH_2; pfam13391 1271864000971 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1271864000972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864000973 ATP binding site [chemical binding]; other site 1271864000974 putative Mg++ binding site [ion binding]; other site 1271864000975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864000976 nucleotide binding region [chemical binding]; other site 1271864000977 ATP-binding site [chemical binding]; other site 1271864000978 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1271864000979 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1271864000980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864000981 ATP binding site [chemical binding]; other site 1271864000982 putative Mg++ binding site [ion binding]; other site 1271864000983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864000984 ATP-binding site [chemical binding]; other site 1271864000985 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1271864000986 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1271864000987 Part of AAA domain; Region: AAA_19; pfam13245 1271864000988 Family description; Region: UvrD_C_2; pfam13538 1271864000989 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1271864000990 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 1271864000991 dimer interface [polypeptide binding]; other site 1271864000992 Mn binding site [ion binding]; other site 1271864000993 K binding site [ion binding]; other site 1271864000994 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1271864000995 HNH endonuclease; Region: HNH_2; pfam13391 1271864000996 hypothetical protein; Provisional; Region: PRK12378 1271864000997 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1271864000998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864000999 S-adenosylmethionine binding site [chemical binding]; other site 1271864001000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864001001 S-adenosylmethionine binding site [chemical binding]; other site 1271864001002 hypothetical protein; Provisional; Region: PRK13687 1271864001003 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1271864001004 Protein of unknown function DUF91; Region: DUF91; cl00709 1271864001005 Uncharacterized conserved protein [Function unknown]; Region: COG3439 1271864001006 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1271864001007 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1271864001008 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1271864001009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864001010 DNA-binding site [nucleotide binding]; DNA binding site 1271864001011 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1271864001012 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1271864001013 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1271864001014 active site 1271864001015 HIGH motif; other site 1271864001016 dimer interface [polypeptide binding]; other site 1271864001017 KMSKS motif; other site 1271864001018 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1271864001019 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1271864001020 aspartate racemase; Region: asp_race; TIGR00035 1271864001021 cell density-dependent motility repressor; Provisional; Region: PRK10082 1271864001022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864001023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1271864001024 dimerization interface [polypeptide binding]; other site 1271864001025 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1271864001026 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1271864001027 dimer interface [polypeptide binding]; other site 1271864001028 active site 1271864001029 hypothetical protein; Provisional; Region: PRK10519 1271864001030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1271864001031 Nucleoside recognition; Region: Gate; pfam07670 1271864001032 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1271864001033 Predicted membrane protein [Function unknown]; Region: COG2733 1271864001034 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1271864001035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864001036 putative substrate translocation pore; other site 1271864001037 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1271864001038 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1271864001039 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1271864001040 NAD(P) binding site [chemical binding]; other site 1271864001041 catalytic residues [active] 1271864001042 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1271864001043 endoribonuclease SymE; Provisional; Region: PRK13605 1271864001044 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1271864001045 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1271864001046 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1271864001047 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1271864001048 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1271864001049 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1271864001050 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1271864001051 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1271864001052 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1271864001053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864001054 ATP binding site [chemical binding]; other site 1271864001055 putative Mg++ binding site [ion binding]; other site 1271864001056 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1271864001057 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1271864001058 Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030 1271864001059 Restriction endonuclease; Region: Mrr_cat; pfam04471 1271864001060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 1271864001061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 1271864001062 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1271864001063 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1271864001064 P-loop, Walker A motif; other site 1271864001065 Base recognition motif; other site 1271864001066 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1271864001067 Uncharacterized small protein [Function unknown]; Region: COG2879 1271864001068 carbon starvation protein A; Provisional; Region: PRK15015 1271864001069 Carbon starvation protein CstA; Region: CstA; pfam02554 1271864001070 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1271864001071 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1271864001072 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1271864001073 dimer interface [polypeptide binding]; other site 1271864001074 ligand binding site [chemical binding]; other site 1271864001075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864001076 dimerization interface [polypeptide binding]; other site 1271864001077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864001078 dimer interface [polypeptide binding]; other site 1271864001079 putative CheW interface [polypeptide binding]; other site 1271864001080 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1271864001081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864001082 Walker A motif; other site 1271864001083 ATP binding site [chemical binding]; other site 1271864001084 Walker B motif; other site 1271864001085 arginine finger; other site 1271864001086 Transcriptional antiterminator [Transcription]; Region: COG3933 1271864001087 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1271864001088 active pocket/dimerization site; other site 1271864001089 active site 1271864001090 phosphorylation site [posttranslational modification] 1271864001091 PRD domain; Region: PRD; pfam00874 1271864001092 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1271864001093 active pocket/dimerization site; other site 1271864001094 active site 1271864001095 phosphorylation site [posttranslational modification] 1271864001096 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1271864001097 active site 1271864001098 phosphorylation site [posttranslational modification] 1271864001099 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1271864001100 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1271864001101 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1271864001102 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1271864001103 dimer interface [polypeptide binding]; other site 1271864001104 active site 1271864001105 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1271864001106 dimer interface [polypeptide binding]; other site 1271864001107 active site 1271864001108 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1271864001109 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1271864001110 putative active site [active] 1271864001111 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1271864001112 phosphoglycerol transferase I; Provisional; Region: PRK03776 1271864001113 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1271864001114 hypothetical protein; Provisional; Region: PRK11667 1271864001115 DNA replication protein DnaC; Validated; Region: PRK07952 1271864001116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864001117 Walker A motif; other site 1271864001118 ATP binding site [chemical binding]; other site 1271864001119 Walker B motif; other site 1271864001120 primosomal protein DnaI; Provisional; Region: PRK02854 1271864001121 hypothetical protein; Provisional; Region: PRK09917 1271864001122 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1271864001123 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1271864001124 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1271864001125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864001126 DNA binding residues [nucleotide binding] 1271864001127 dimerization interface [polypeptide binding]; other site 1271864001128 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1271864001129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864001130 DNA binding residues [nucleotide binding] 1271864001131 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1271864001132 putative deacylase active site [active] 1271864001133 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1271864001134 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1271864001135 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1271864001136 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1271864001137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864001138 metal binding site [ion binding]; metal-binding site 1271864001139 active site 1271864001140 I-site; other site 1271864001141 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1271864001142 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1271864001143 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1271864001144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864001145 S-adenosylmethionine binding site [chemical binding]; other site 1271864001146 DNA polymerase III subunit psi; Validated; Region: PRK06856 1271864001147 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1271864001148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864001149 Coenzyme A binding pocket [chemical binding]; other site 1271864001150 dUMP phosphatase; Provisional; Region: PRK09449 1271864001151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864001152 motif II; other site 1271864001153 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1271864001154 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1271864001155 G1 box; other site 1271864001156 putative GEF interaction site [polypeptide binding]; other site 1271864001157 GTP/Mg2+ binding site [chemical binding]; other site 1271864001158 Switch I region; other site 1271864001159 G2 box; other site 1271864001160 G3 box; other site 1271864001161 Switch II region; other site 1271864001162 G4 box; other site 1271864001163 G5 box; other site 1271864001164 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1271864001165 periplasmic protein; Provisional; Region: PRK10568 1271864001166 BON domain; Region: BON; pfam04972 1271864001167 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1271864001168 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1271864001169 active site 1271864001170 nucleophile elbow; other site 1271864001171 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1271864001172 active site 1271864001173 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1271864001174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864001175 FeS/SAM binding site; other site 1271864001176 hypothetical protein; Provisional; Region: PRK10977 1271864001177 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1271864001178 intersubunit interface [polypeptide binding]; other site 1271864001179 active site 1271864001180 catalytic residue [active] 1271864001181 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1271864001182 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1271864001183 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1271864001184 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1271864001185 phosphopentomutase; Provisional; Region: PRK05362 1271864001186 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1271864001187 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1271864001188 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1271864001189 hypothetical protein; Provisional; Region: PRK15301 1271864001190 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1271864001191 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864001192 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864001193 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864001194 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1271864001195 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864001196 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864001197 hypothetical protein; Provisional; Region: PRK15302 1271864001198 hypothetical protein; Provisional; Region: PRK15303 1271864001199 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1271864001200 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1271864001201 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1271864001202 hypothetical protein; Provisional; Region: PRK11246 1271864001203 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1271864001204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864001205 motif II; other site 1271864001206 DNA repair protein RadA; Region: sms; TIGR00416 1271864001207 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1271864001208 Walker A motif/ATP binding site; other site 1271864001209 ATP binding site [chemical binding]; other site 1271864001210 Walker B motif; other site 1271864001211 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1271864001212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864001213 non-specific DNA binding site [nucleotide binding]; other site 1271864001214 salt bridge; other site 1271864001215 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1271864001216 sequence-specific DNA binding site [nucleotide binding]; other site 1271864001217 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1271864001218 active site 1271864001219 (T/H)XGH motif; other site 1271864001220 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1271864001221 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1271864001222 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864001223 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864001224 ABC transporter; Region: ABC_tran_2; pfam12848 1271864001225 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864001226 lytic murein transglycosylase; Provisional; Region: PRK11619 1271864001227 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864001228 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864001229 catalytic residue [active] 1271864001230 Trp operon repressor; Provisional; Region: PRK01381 1271864001231 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1271864001232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1271864001233 catalytic core [active] 1271864001234 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1271864001235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864001236 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1271864001237 hypothetical protein; Provisional; Region: PRK10756 1271864001238 CreA protein; Region: CreA; pfam05981 1271864001239 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1271864001240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864001241 active site 1271864001242 phosphorylation site [posttranslational modification] 1271864001243 intermolecular recognition site; other site 1271864001244 dimerization interface [polypeptide binding]; other site 1271864001245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864001246 DNA binding site [nucleotide binding] 1271864001247 sensory histidine kinase CreC; Provisional; Region: PRK11100 1271864001248 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1271864001249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864001250 dimer interface [polypeptide binding]; other site 1271864001251 phosphorylation site [posttranslational modification] 1271864001252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864001253 ATP binding site [chemical binding]; other site 1271864001254 Mg2+ binding site [ion binding]; other site 1271864001255 G-X-G motif; other site 1271864001256 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1271864001257 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1271864001258 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1271864001259 putative fimbrial protein SthD; Provisional; Region: PRK15293 1271864001260 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1271864001261 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864001262 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864001263 putative fimbrial protein SthA; Provisional; Region: PRK15296 1271864001264 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1271864001265 Helix-turn-helix domain; Region: HTH_36; pfam13730 1271864001266 two-component response regulator; Provisional; Region: PRK11173 1271864001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864001268 active site 1271864001269 phosphorylation site [posttranslational modification] 1271864001270 intermolecular recognition site; other site 1271864001271 dimerization interface [polypeptide binding]; other site 1271864001272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864001273 DNA binding site [nucleotide binding] 1271864001274 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1271864001275 putative RNA methyltransferase; Provisional; Region: PRK10433 1271864001276 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1271864001277 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1271864001278 putative catalytic residues [active] 1271864001279 putative nucleotide binding site [chemical binding]; other site 1271864001280 putative aspartate binding site [chemical binding]; other site 1271864001281 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1271864001282 dimer interface [polypeptide binding]; other site 1271864001283 putative threonine allosteric regulatory site; other site 1271864001284 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1271864001285 putative threonine allosteric regulatory site; other site 1271864001286 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1271864001287 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1271864001288 homoserine kinase; Provisional; Region: PRK01212 1271864001289 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1271864001290 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1271864001291 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1271864001292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864001293 catalytic residue [active] 1271864001294 hypothetical protein; Validated; Region: PRK02101 1271864001295 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1271864001296 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1271864001297 transaldolase-like protein; Provisional; Region: PTZ00411 1271864001298 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1271864001299 active site 1271864001300 dimer interface [polypeptide binding]; other site 1271864001301 catalytic residue [active] 1271864001302 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1271864001303 MPT binding site; other site 1271864001304 trimer interface [polypeptide binding]; other site 1271864001305 hypothetical protein; Provisional; Region: PRK10659 1271864001306 hypothetical protein; Provisional; Region: PRK10236 1271864001307 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1271864001308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1271864001309 hypothetical protein; Provisional; Region: PRK10154 1271864001310 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1271864001311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1271864001312 nucleotide binding site [chemical binding]; other site 1271864001313 chaperone protein DnaJ; Provisional; Region: PRK10767 1271864001314 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1271864001315 HSP70 interaction site [polypeptide binding]; other site 1271864001316 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1271864001317 substrate binding site [polypeptide binding]; other site 1271864001318 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1271864001319 Zn binding sites [ion binding]; other site 1271864001320 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1271864001321 dimer interface [polypeptide binding]; other site 1271864001322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864001323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864001324 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1271864001325 substrate binding pocket [chemical binding]; other site 1271864001326 dimerization interface [polypeptide binding]; other site 1271864001327 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1271864001328 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1271864001329 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1271864001330 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1271864001331 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1271864001332 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1271864001333 active site 1271864001334 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1271864001335 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1271864001336 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1271864001337 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1271864001338 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1271864001339 Helix-turn-helix domain; Region: HTH_36; pfam13730 1271864001340 fimbrial protein BcfA; Provisional; Region: PRK15187 1271864001341 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 1271864001342 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864001343 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864001344 outer membrane usher protein; Provisional; Region: PRK15193 1271864001345 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864001346 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864001347 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864001348 fimbrial protein BcfD; Provisional; Region: PRK15189 1271864001349 fimbrial protein BcfE; Provisional; Region: PRK15190 1271864001350 fimbrial protein BcfF; Provisional; Region: PRK15191 1271864001351 fimbrial chaperone BcfG; Provisional; Region: PRK15192 1271864001352 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864001353 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864001354 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1271864001355 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1271864001356 catalytic residues [active] 1271864001357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1271864001358 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1271864001359 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 1271864001360 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1271864001361 Sulfatase; Region: Sulfatase; pfam00884 1271864001362 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1271864001363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864001364 FeS/SAM binding site; other site 1271864001365 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1271864001366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1271864001367 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1271864001368 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1271864001369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864001370 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1271864001371 putative dimerization interface [polypeptide binding]; other site 1271864001372 putative alpha-glucosidase; Provisional; Region: PRK10658 1271864001373 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1271864001374 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1271864001375 putative active site [active] 1271864001376 putative catalytic site [active] 1271864001377 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1271864001378 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1271864001379 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1271864001380 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1271864001381 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1271864001382 active site 1271864001383 Riboflavin kinase; Region: Flavokinase; smart00904 1271864001384 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1271864001385 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1271864001386 active site 1271864001387 HIGH motif; other site 1271864001388 nucleotide binding site [chemical binding]; other site 1271864001389 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1271864001390 active site 1271864001391 KMSKS motif; other site 1271864001392 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1271864001393 tRNA binding surface [nucleotide binding]; other site 1271864001394 anticodon binding site; other site 1271864001395 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1271864001396 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1271864001397 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1271864001398 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1271864001399 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1271864001400 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1271864001401 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1271864001402 active site 1271864001403 tetramer interface [polypeptide binding]; other site 1271864001404 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1271864001405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864001406 active site 1271864001407 phosphorylation site [posttranslational modification] 1271864001408 intermolecular recognition site; other site 1271864001409 dimerization interface [polypeptide binding]; other site 1271864001410 Transcriptional regulator; Region: CitT; pfam12431 1271864001411 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1271864001412 PAS domain; Region: PAS; smart00091 1271864001413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864001414 ATP binding site [chemical binding]; other site 1271864001415 Mg2+ binding site [ion binding]; other site 1271864001416 G-X-G motif; other site 1271864001417 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1271864001418 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1271864001419 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1271864001420 active site 1271864001421 catalytic residues [active] 1271864001422 metal binding site [ion binding]; metal-binding site 1271864001423 homodimer binding site [polypeptide binding]; other site 1271864001424 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1271864001425 carboxyltransferase (CT) interaction site; other site 1271864001426 biotinylation site [posttranslational modification]; other site 1271864001427 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1271864001428 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1271864001429 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1271864001430 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1271864001431 putative active site [active] 1271864001432 (T/H)XGH motif; other site 1271864001433 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1271864001434 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1271864001435 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1271864001436 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1271864001437 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1271864001438 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1271864001439 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1271864001440 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1271864001441 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1271864001442 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1271864001443 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1271864001444 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1271864001445 catalytic site [active] 1271864001446 subunit interface [polypeptide binding]; other site 1271864001447 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1271864001448 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1271864001449 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1271864001450 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1271864001451 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1271864001452 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1271864001453 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1271864001454 IMP binding site; other site 1271864001455 dimer interface [polypeptide binding]; other site 1271864001456 interdomain contacts; other site 1271864001457 partial ornithine binding site; other site 1271864001458 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1271864001459 carnitine operon protein CaiE; Provisional; Region: PRK13627 1271864001460 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1271864001461 putative trimer interface [polypeptide binding]; other site 1271864001462 putative metal binding site [ion binding]; other site 1271864001463 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1271864001464 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1271864001465 substrate binding site [chemical binding]; other site 1271864001466 oxyanion hole (OAH) forming residues; other site 1271864001467 trimer interface [polypeptide binding]; other site 1271864001468 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1271864001469 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1271864001470 acyl-activating enzyme (AAE) consensus motif; other site 1271864001471 putative AMP binding site [chemical binding]; other site 1271864001472 putative active site [active] 1271864001473 putative CoA binding site [chemical binding]; other site 1271864001474 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1271864001475 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1271864001476 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1271864001477 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1271864001478 active site 1271864001479 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1271864001480 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1271864001481 Ligand binding site [chemical binding]; other site 1271864001482 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1271864001483 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1271864001484 Electron transfer flavoprotein domain; Region: ETF; smart00893 1271864001485 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1271864001486 putative oxidoreductase FixC; Provisional; Region: PRK10157 1271864001487 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1271864001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864001489 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1271864001490 putative substrate translocation pore; other site 1271864001491 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1271864001492 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864001493 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1271864001494 Sulfatase; Region: Sulfatase; cl17466 1271864001495 Sulfatase; Region: Sulfatase; cl17466 1271864001496 Sulfatase; Region: Sulfatase; cl17466 1271864001497 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1271864001498 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1271864001499 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1271864001500 TrkA-N domain; Region: TrkA_N; pfam02254 1271864001501 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1271864001502 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1271864001503 folate binding site [chemical binding]; other site 1271864001504 NADP+ binding site [chemical binding]; other site 1271864001505 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1271864001506 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1271864001507 active site 1271864001508 metal binding site [ion binding]; metal-binding site 1271864001509 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1271864001510 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1271864001511 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1271864001512 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1271864001513 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1271864001514 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1271864001515 SurA N-terminal domain; Region: SurA_N; pfam09312 1271864001516 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1271864001517 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1271864001518 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1271864001519 OstA-like protein; Region: OstA; pfam03968 1271864001520 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1271864001521 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1271864001522 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1271864001523 putative metal binding site [ion binding]; other site 1271864001524 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1271864001525 HSP70 interaction site [polypeptide binding]; other site 1271864001526 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1271864001527 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1271864001528 active site 1271864001529 ATP-dependent helicase HepA; Validated; Region: PRK04914 1271864001530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864001531 ATP binding site [chemical binding]; other site 1271864001532 putative Mg++ binding site [ion binding]; other site 1271864001533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864001534 nucleotide binding region [chemical binding]; other site 1271864001535 ATP-binding site [chemical binding]; other site 1271864001536 DNA polymerase II; Reviewed; Region: PRK05762 1271864001537 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1271864001538 active site 1271864001539 catalytic site [active] 1271864001540 substrate binding site [chemical binding]; other site 1271864001541 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1271864001542 active site 1271864001543 metal-binding site 1271864001544 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1271864001545 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1271864001546 putative active site [active] 1271864001547 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1271864001548 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1271864001549 intersubunit interface [polypeptide binding]; other site 1271864001550 active site 1271864001551 Zn2+ binding site [ion binding]; other site 1271864001552 L-arabinose isomerase; Provisional; Region: PRK02929 1271864001553 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1271864001554 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1271864001555 trimer interface [polypeptide binding]; other site 1271864001556 putative substrate binding site [chemical binding]; other site 1271864001557 putative metal binding site [ion binding]; other site 1271864001558 ribulokinase; Provisional; Region: PRK04123 1271864001559 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1271864001560 N- and C-terminal domain interface [polypeptide binding]; other site 1271864001561 active site 1271864001562 MgATP binding site [chemical binding]; other site 1271864001563 catalytic site [active] 1271864001564 metal binding site [ion binding]; metal-binding site 1271864001565 carbohydrate binding site [chemical binding]; other site 1271864001566 homodimer interface [polypeptide binding]; other site 1271864001567 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1271864001568 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1271864001569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864001570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864001571 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1271864001572 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1271864001573 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1271864001574 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1271864001575 Walker A/P-loop; other site 1271864001576 ATP binding site [chemical binding]; other site 1271864001577 Q-loop/lid; other site 1271864001578 ABC transporter signature motif; other site 1271864001579 Walker B; other site 1271864001580 D-loop; other site 1271864001581 H-loop/switch region; other site 1271864001582 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1271864001583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864001584 dimer interface [polypeptide binding]; other site 1271864001585 conserved gate region; other site 1271864001586 putative PBP binding loops; other site 1271864001587 ABC-ATPase subunit interface; other site 1271864001588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864001589 dimer interface [polypeptide binding]; other site 1271864001590 conserved gate region; other site 1271864001591 putative PBP binding loops; other site 1271864001592 ABC-ATPase subunit interface; other site 1271864001593 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1271864001594 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1271864001595 transcriptional regulator SgrR; Provisional; Region: PRK13626 1271864001596 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1271864001597 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1271864001598 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1271864001599 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1271864001600 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1271864001601 substrate binding site [chemical binding]; other site 1271864001602 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1271864001603 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1271864001604 substrate binding site [chemical binding]; other site 1271864001605 ligand binding site [chemical binding]; other site 1271864001606 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1271864001607 tartrate dehydrogenase; Region: TTC; TIGR02089 1271864001608 2-isopropylmalate synthase; Validated; Region: PRK00915 1271864001609 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1271864001610 active site 1271864001611 catalytic residues [active] 1271864001612 metal binding site [ion binding]; metal-binding site 1271864001613 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1271864001614 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1271864001615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864001616 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1271864001617 putative substrate binding pocket [chemical binding]; other site 1271864001618 putative dimerization interface [polypeptide binding]; other site 1271864001619 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1271864001620 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1271864001621 PYR/PP interface [polypeptide binding]; other site 1271864001622 dimer interface [polypeptide binding]; other site 1271864001623 TPP binding site [chemical binding]; other site 1271864001624 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1271864001625 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1271864001626 TPP-binding site [chemical binding]; other site 1271864001627 dimer interface [polypeptide binding]; other site 1271864001628 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1271864001629 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1271864001630 putative valine binding site [chemical binding]; other site 1271864001631 dimer interface [polypeptide binding]; other site 1271864001632 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1271864001633 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1271864001634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864001635 DNA binding site [nucleotide binding] 1271864001636 domain linker motif; other site 1271864001637 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1271864001638 dimerization interface [polypeptide binding]; other site 1271864001639 ligand binding site [chemical binding]; other site 1271864001640 mraZ protein; Region: TIGR00242 1271864001641 MraZ protein; Region: MraZ; pfam02381 1271864001642 MraZ protein; Region: MraZ; pfam02381 1271864001643 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1271864001644 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1271864001645 cell division protein FtsL; Provisional; Region: PRK10772 1271864001646 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1271864001647 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1271864001648 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1271864001649 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1271864001650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1271864001651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1271864001652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1271864001653 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1271864001654 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1271864001655 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1271864001656 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1271864001657 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1271864001658 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1271864001659 Mg++ binding site [ion binding]; other site 1271864001660 putative catalytic motif [active] 1271864001661 putative substrate binding site [chemical binding]; other site 1271864001662 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1271864001663 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1271864001664 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1271864001665 cell division protein FtsW; Provisional; Region: PRK10774 1271864001666 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1271864001667 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1271864001668 active site 1271864001669 homodimer interface [polypeptide binding]; other site 1271864001670 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1271864001671 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1271864001672 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1271864001673 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1271864001674 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1271864001675 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1271864001676 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1271864001677 cell division protein FtsQ; Provisional; Region: PRK10775 1271864001678 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1271864001679 Cell division protein FtsQ; Region: FtsQ; pfam03799 1271864001680 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1271864001681 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864001682 Cell division protein FtsA; Region: FtsA; pfam14450 1271864001683 cell division protein FtsZ; Validated; Region: PRK09330 1271864001684 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1271864001685 nucleotide binding site [chemical binding]; other site 1271864001686 SulA interaction site; other site 1271864001687 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1271864001688 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1271864001689 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1271864001690 SecA regulator SecM; Provisional; Region: PRK02943 1271864001691 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1271864001692 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1271864001693 SEC-C motif; Region: SEC-C; pfam02810 1271864001694 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1271864001695 active site 1271864001696 8-oxo-dGMP binding site [chemical binding]; other site 1271864001697 nudix motif; other site 1271864001698 metal binding site [ion binding]; metal-binding site 1271864001699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1271864001700 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1271864001701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1271864001702 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1271864001703 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1271864001704 CoA-binding site [chemical binding]; other site 1271864001705 ATP-binding [chemical binding]; other site 1271864001706 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1271864001707 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1271864001708 active site 1271864001709 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1271864001710 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1271864001711 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1271864001712 hypothetical protein; Provisional; Region: PRK10436 1271864001713 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1271864001714 Walker A motif; other site 1271864001715 ATP binding site [chemical binding]; other site 1271864001716 Walker B motif; other site 1271864001717 putative major pilin subunit; Provisional; Region: PRK10574 1271864001718 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1271864001719 Pilin (bacterial filament); Region: Pilin; pfam00114 1271864001720 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1271864001721 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1271864001722 dimerization interface [polypeptide binding]; other site 1271864001723 active site 1271864001724 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1271864001725 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1271864001726 amidase catalytic site [active] 1271864001727 Zn binding residues [ion binding]; other site 1271864001728 substrate binding site [chemical binding]; other site 1271864001729 regulatory protein AmpE; Provisional; Region: PRK10987 1271864001730 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1271864001731 active site 1271864001732 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1271864001733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864001734 putative substrate translocation pore; other site 1271864001735 aromatic amino acid transporter; Provisional; Region: PRK10238 1271864001736 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1271864001737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864001738 DNA-binding site [nucleotide binding]; DNA binding site 1271864001739 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1271864001740 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1271864001741 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1271864001742 dimer interface [polypeptide binding]; other site 1271864001743 TPP-binding site [chemical binding]; other site 1271864001744 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1271864001745 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1271864001746 E3 interaction surface; other site 1271864001747 lipoyl attachment site [posttranslational modification]; other site 1271864001748 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1271864001749 E3 interaction surface; other site 1271864001750 lipoyl attachment site [posttranslational modification]; other site 1271864001751 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1271864001752 E3 interaction surface; other site 1271864001753 lipoyl attachment site [posttranslational modification]; other site 1271864001754 e3 binding domain; Region: E3_binding; pfam02817 1271864001755 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1271864001756 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1271864001757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1271864001758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864001759 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1271864001760 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1271864001761 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1271864001762 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1271864001763 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1271864001764 substrate binding site [chemical binding]; other site 1271864001765 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1271864001766 substrate binding site [chemical binding]; other site 1271864001767 ligand binding site [chemical binding]; other site 1271864001768 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1271864001769 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1271864001770 aconitate hydratase 2; Provisional; Region: PLN00094 1271864001771 putative inner membrane protein; Provisional; Region: PRK09823 1271864001772 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1271864001773 active site 1271864001774 hypothetical protein; Provisional; Region: PRK05248 1271864001775 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 1271864001776 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1271864001777 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1271864001778 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864001779 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1271864001780 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864001781 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1271864001782 spermidine synthase; Provisional; Region: PRK00811 1271864001783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864001784 S-adenosylmethionine binding site [chemical binding]; other site 1271864001785 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1271864001786 multicopper oxidase; Provisional; Region: PRK10965 1271864001787 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1271864001788 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1271864001789 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1271864001790 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1271864001791 Trp docking motif [polypeptide binding]; other site 1271864001792 putative active site [active] 1271864001793 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1271864001794 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864001795 active site 1271864001796 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1271864001797 active site clefts [active] 1271864001798 zinc binding site [ion binding]; other site 1271864001799 dimer interface [polypeptide binding]; other site 1271864001800 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1271864001801 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1271864001802 Walker A/P-loop; other site 1271864001803 ATP binding site [chemical binding]; other site 1271864001804 Q-loop/lid; other site 1271864001805 ABC transporter signature motif; other site 1271864001806 Walker B; other site 1271864001807 D-loop; other site 1271864001808 H-loop/switch region; other site 1271864001809 inner membrane transport permease; Provisional; Region: PRK15066 1271864001810 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1271864001811 putative fimbrial protein StiH; Provisional; Region: PRK15297 1271864001812 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 1271864001813 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864001814 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864001815 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864001816 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 1271864001817 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864001818 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864001819 fimbrial protein StiA; Provisional; Region: PRK15300 1271864001820 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1271864001821 active pocket/dimerization site; other site 1271864001822 active site 1271864001823 phosphorylation site [posttranslational modification] 1271864001824 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1271864001825 putative active site [active] 1271864001826 putative metal binding site [ion binding]; other site 1271864001827 putative fimbrial protein StkG; Provisional; Region: PRK15305 1271864001828 putative fimbrial protein StaF; Provisional; Region: PRK15262 1271864001829 putative fimbrial protein StaE; Provisional; Region: PRK15263 1271864001830 putative fimbrial protein StkD; Provisional; Region: PRK15306 1271864001831 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1271864001832 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864001833 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864001834 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864001835 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1271864001836 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864001837 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864001838 major fimbrial protein StkA; Provisional; Region: PRK15307 1271864001839 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1271864001840 tetramerization interface [polypeptide binding]; other site 1271864001841 active site 1271864001842 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1271864001843 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1271864001844 active site 1271864001845 ATP-binding site [chemical binding]; other site 1271864001846 pantoate-binding site; other site 1271864001847 HXXH motif; other site 1271864001848 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1271864001849 oligomerization interface [polypeptide binding]; other site 1271864001850 active site 1271864001851 metal binding site [ion binding]; metal-binding site 1271864001852 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1271864001853 catalytic center binding site [active] 1271864001854 ATP binding site [chemical binding]; other site 1271864001855 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1271864001856 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1271864001857 active site 1271864001858 NTP binding site [chemical binding]; other site 1271864001859 metal binding triad [ion binding]; metal-binding site 1271864001860 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1271864001861 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1271864001862 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1271864001863 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1271864001864 active site 1271864001865 nucleotide binding site [chemical binding]; other site 1271864001866 HIGH motif; other site 1271864001867 KMSKS motif; other site 1271864001868 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1271864001869 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1271864001870 2'-5' RNA ligase; Provisional; Region: PRK15124 1271864001871 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1271864001872 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1271864001873 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1271864001874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864001875 ATP binding site [chemical binding]; other site 1271864001876 putative Mg++ binding site [ion binding]; other site 1271864001877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864001878 nucleotide binding region [chemical binding]; other site 1271864001879 ATP-binding site [chemical binding]; other site 1271864001880 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1271864001881 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1271864001882 Transglycosylase; Region: Transgly; pfam00912 1271864001883 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1271864001884 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1271864001885 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864001886 N-terminal plug; other site 1271864001887 ligand-binding site [chemical binding]; other site 1271864001888 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1271864001889 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1271864001890 Walker A/P-loop; other site 1271864001891 ATP binding site [chemical binding]; other site 1271864001892 Q-loop/lid; other site 1271864001893 ABC transporter signature motif; other site 1271864001894 Walker B; other site 1271864001895 D-loop; other site 1271864001896 H-loop/switch region; other site 1271864001897 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1271864001898 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1271864001899 siderophore binding site; other site 1271864001900 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1271864001901 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864001902 ABC-ATPase subunit interface; other site 1271864001903 dimer interface [polypeptide binding]; other site 1271864001904 putative PBP binding regions; other site 1271864001905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864001906 ABC-ATPase subunit interface; other site 1271864001907 dimer interface [polypeptide binding]; other site 1271864001908 putative PBP binding regions; other site 1271864001909 putative fimbrial subunit StfA; Provisional; Region: PRK15283 1271864001910 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1271864001911 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864001912 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864001913 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864001914 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1271864001915 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864001916 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864001917 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 1271864001918 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 1271864001919 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 1271864001920 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1271864001921 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1271864001922 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1271864001923 inhibitor-cofactor binding pocket; inhibition site 1271864001924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864001925 catalytic residue [active] 1271864001926 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1271864001927 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1271864001928 Cl- selectivity filter; other site 1271864001929 Cl- binding residues [ion binding]; other site 1271864001930 pore gating glutamate residue; other site 1271864001931 dimer interface [polypeptide binding]; other site 1271864001932 H+/Cl- coupling transport residue; other site 1271864001933 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1271864001934 hypothetical protein; Provisional; Region: PRK10578 1271864001935 UPF0126 domain; Region: UPF0126; pfam03458 1271864001936 UPF0126 domain; Region: UPF0126; pfam03458 1271864001937 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1271864001938 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1271864001939 cobalamin binding residues [chemical binding]; other site 1271864001940 putative BtuC binding residues; other site 1271864001941 dimer interface [polypeptide binding]; other site 1271864001942 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1271864001943 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1271864001944 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1271864001945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1271864001946 Zn2+ binding site [ion binding]; other site 1271864001947 Mg2+ binding site [ion binding]; other site 1271864001948 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1271864001949 serine endoprotease; Provisional; Region: PRK10942 1271864001950 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1271864001951 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1271864001952 protein binding site [polypeptide binding]; other site 1271864001953 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1271864001954 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1271864001955 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1271864001956 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1271864001957 hypothetical protein; Provisional; Region: PRK13677 1271864001958 shikimate transporter; Provisional; Region: PRK09952 1271864001959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864001960 putative substrate translocation pore; other site 1271864001961 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1271864001962 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1271864001963 trimer interface [polypeptide binding]; other site 1271864001964 active site 1271864001965 substrate binding site [chemical binding]; other site 1271864001966 CoA binding site [chemical binding]; other site 1271864001967 PII uridylyl-transferase; Provisional; Region: PRK05007 1271864001968 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1271864001969 metal binding triad; other site 1271864001970 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1271864001971 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1271864001972 Zn2+ binding site [ion binding]; other site 1271864001973 Mg2+ binding site [ion binding]; other site 1271864001974 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1271864001975 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1271864001976 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1271864001977 active site 1271864001978 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1271864001979 rRNA interaction site [nucleotide binding]; other site 1271864001980 S8 interaction site; other site 1271864001981 putative laminin-1 binding site; other site 1271864001982 elongation factor Ts; Provisional; Region: tsf; PRK09377 1271864001983 UBA/TS-N domain; Region: UBA; pfam00627 1271864001984 Elongation factor TS; Region: EF_TS; pfam00889 1271864001985 Elongation factor TS; Region: EF_TS; pfam00889 1271864001986 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1271864001987 putative nucleotide binding site [chemical binding]; other site 1271864001988 uridine monophosphate binding site [chemical binding]; other site 1271864001989 homohexameric interface [polypeptide binding]; other site 1271864001990 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1271864001991 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1271864001992 hinge region; other site 1271864001993 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1271864001994 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1271864001995 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1271864001996 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1271864001997 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1271864001998 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1271864001999 catalytic residue [active] 1271864002000 putative FPP diphosphate binding site; other site 1271864002001 putative FPP binding hydrophobic cleft; other site 1271864002002 dimer interface [polypeptide binding]; other site 1271864002003 putative IPP diphosphate binding site; other site 1271864002004 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1271864002005 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1271864002006 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1271864002007 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1271864002008 active site 1271864002009 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1271864002010 protein binding site [polypeptide binding]; other site 1271864002011 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1271864002012 protein binding site [polypeptide binding]; other site 1271864002013 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1271864002014 putative substrate binding region [chemical binding]; other site 1271864002015 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1271864002016 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1271864002017 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1271864002018 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1271864002019 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1271864002020 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1271864002021 Surface antigen; Region: Bac_surface_Ag; pfam01103 1271864002022 periplasmic chaperone; Provisional; Region: PRK10780 1271864002023 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1271864002024 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1271864002025 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1271864002026 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1271864002027 trimer interface [polypeptide binding]; other site 1271864002028 active site 1271864002029 UDP-GlcNAc binding site [chemical binding]; other site 1271864002030 lipid binding site [chemical binding]; lipid-binding site 1271864002031 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1271864002032 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1271864002033 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1271864002034 active site 1271864002035 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1271864002036 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1271864002037 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1271864002038 RNA/DNA hybrid binding site [nucleotide binding]; other site 1271864002039 active site 1271864002040 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1271864002041 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1271864002042 putative active site [active] 1271864002043 putative PHP Thumb interface [polypeptide binding]; other site 1271864002044 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1271864002045 generic binding surface II; other site 1271864002046 generic binding surface I; other site 1271864002047 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1271864002048 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1271864002049 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1271864002050 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1271864002051 putative sugar binding site [chemical binding]; other site 1271864002052 catalytic residues [active] 1271864002053 PKD domain; Region: PKD; pfam00801 1271864002054 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1271864002055 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1271864002056 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1271864002057 homodimer interface [polypeptide binding]; other site 1271864002058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864002059 catalytic residue [active] 1271864002060 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1271864002061 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1271864002062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1271864002063 putative metal binding site [ion binding]; other site 1271864002064 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1271864002065 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1271864002066 Ligand Binding Site [chemical binding]; other site 1271864002067 TilS substrate binding domain; Region: TilS; pfam09179 1271864002068 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1271864002069 Rho-binding antiterminator; Provisional; Region: PRK11625 1271864002070 hypothetical protein; Provisional; Region: PRK04964 1271864002071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1271864002072 hypothetical protein; Provisional; Region: PRK09256 1271864002073 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1271864002074 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1271864002075 NlpE N-terminal domain; Region: NlpE; pfam04170 1271864002076 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1271864002077 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1271864002078 dimer interface [polypeptide binding]; other site 1271864002079 motif 1; other site 1271864002080 active site 1271864002081 motif 2; other site 1271864002082 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1271864002083 putative deacylase active site [active] 1271864002084 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1271864002085 active site 1271864002086 motif 3; other site 1271864002087 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1271864002088 anticodon binding site; other site 1271864002089 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1271864002090 homodimer interaction site [polypeptide binding]; other site 1271864002091 cofactor binding site; other site 1271864002092 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1271864002093 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1271864002094 lipoprotein, YaeC family; Region: TIGR00363 1271864002095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864002096 dimer interface [polypeptide binding]; other site 1271864002097 conserved gate region; other site 1271864002098 ABC-ATPase subunit interface; other site 1271864002099 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1271864002100 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1271864002101 Walker A/P-loop; other site 1271864002102 ATP binding site [chemical binding]; other site 1271864002103 Q-loop/lid; other site 1271864002104 ABC transporter signature motif; other site 1271864002105 Walker B; other site 1271864002106 D-loop; other site 1271864002107 H-loop/switch region; other site 1271864002108 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1271864002109 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1271864002110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864002111 active site 1271864002112 motif I; other site 1271864002113 motif II; other site 1271864002114 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864002115 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864002116 active site 1271864002117 catalytic tetrad [active] 1271864002118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864002119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864002120 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1271864002121 putative effector binding pocket; other site 1271864002122 dimerization interface [polypeptide binding]; other site 1271864002123 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1271864002124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002125 putative substrate translocation pore; other site 1271864002126 hypothetical protein; Provisional; Region: PRK05421 1271864002127 putative catalytic site [active] 1271864002128 putative metal binding site [ion binding]; other site 1271864002129 putative phosphate binding site [ion binding]; other site 1271864002130 putative catalytic site [active] 1271864002131 putative phosphate binding site [ion binding]; other site 1271864002132 putative metal binding site [ion binding]; other site 1271864002133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864002134 S-adenosylmethionine binding site [chemical binding]; other site 1271864002135 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1271864002136 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864002137 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864002138 catalytic residue [active] 1271864002139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864002140 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864002141 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1271864002142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864002143 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1271864002144 RNA/DNA hybrid binding site [nucleotide binding]; other site 1271864002145 active site 1271864002146 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1271864002147 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1271864002148 active site 1271864002149 catalytic site [active] 1271864002150 substrate binding site [chemical binding]; other site 1271864002151 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1271864002152 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1271864002153 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1271864002154 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1271864002155 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1271864002156 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1271864002157 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1271864002158 ImpE protein; Region: ImpE; pfam07024 1271864002159 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1271864002160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864002161 Walker A motif; other site 1271864002162 ATP binding site [chemical binding]; other site 1271864002163 Walker B motif; other site 1271864002164 arginine finger; other site 1271864002165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864002166 Walker A motif; other site 1271864002167 ATP binding site [chemical binding]; other site 1271864002168 Walker B motif; other site 1271864002169 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1271864002170 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1271864002171 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1271864002172 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1271864002173 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1271864002174 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1271864002175 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1271864002176 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1271864002177 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1271864002178 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1271864002179 hypothetical protein; Provisional; Region: PRK08126 1271864002180 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1271864002181 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1271864002182 ligand binding site [chemical binding]; other site 1271864002183 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1271864002184 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1271864002185 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1271864002186 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1271864002187 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1271864002188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 1271864002189 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1271864002190 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1271864002191 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1271864002192 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1271864002193 PAAR motif; Region: PAAR_motif; pfam05488 1271864002194 RHS Repeat; Region: RHS_repeat; cl11982 1271864002195 RHS Repeat; Region: RHS_repeat; cl11982 1271864002196 RHS Repeat; Region: RHS_repeat; cl11982 1271864002197 RHS Repeat; Region: RHS_repeat; pfam05593 1271864002198 RHS Repeat; Region: RHS_repeat; pfam05593 1271864002199 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1271864002200 RHS Repeat; Region: RHS_repeat; pfam05593 1271864002201 RHS Repeat; Region: RHS_repeat; pfam05593 1271864002202 RHS Repeat; Region: RHS_repeat; pfam05593 1271864002203 RHS Repeat; Region: RHS_repeat; pfam05593 1271864002204 RHS Repeat; Region: RHS_repeat; pfam05593 1271864002205 RHS protein; Region: RHS; pfam03527 1271864002206 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1271864002207 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1271864002208 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1271864002209 Transposase; Region: HTH_Tnp_1; cl17663 1271864002210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1271864002211 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1271864002212 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1271864002213 putative fimbrial subunit TcfB; Provisional; Region: PRK15309 1271864002214 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1271864002215 putative fimbrial protein TcfD; Provisional; Region: PRK15311 1271864002216 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1271864002217 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1271864002218 AsnC family; Region: AsnC_trans_reg; pfam01037 1271864002219 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1271864002220 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1271864002221 dimer interface [polypeptide binding]; other site 1271864002222 C-N hydrolase family amidase; Provisional; Region: PRK10438 1271864002223 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1271864002224 putative active site [active] 1271864002225 catalytic triad [active] 1271864002226 dimer interface [polypeptide binding]; other site 1271864002227 multimer interface [polypeptide binding]; other site 1271864002228 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1271864002229 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1271864002230 active site 1271864002231 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1271864002232 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1271864002233 dimer interface [polypeptide binding]; other site 1271864002234 active site 1271864002235 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1271864002236 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1271864002237 putative active site [active] 1271864002238 putative dimer interface [polypeptide binding]; other site 1271864002239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1271864002240 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1271864002241 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1271864002242 active site 1271864002243 DNA polymerase IV; Validated; Region: PRK02406 1271864002244 DNA binding site [nucleotide binding] 1271864002245 hypothetical protein; Reviewed; Region: PRK09588 1271864002246 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1271864002247 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1271864002248 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1271864002249 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1271864002250 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1271864002251 metal binding site [ion binding]; metal-binding site 1271864002252 dimer interface [polypeptide binding]; other site 1271864002253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864002254 active site 1271864002255 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1271864002256 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1271864002257 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864002258 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1271864002259 trimer interface [polypeptide binding]; other site 1271864002260 eyelet of channel; other site 1271864002261 gamma-glutamyl kinase; Provisional; Region: PRK05429 1271864002262 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1271864002263 nucleotide binding site [chemical binding]; other site 1271864002264 homotetrameric interface [polypeptide binding]; other site 1271864002265 putative phosphate binding site [ion binding]; other site 1271864002266 putative allosteric binding site; other site 1271864002267 PUA domain; Region: PUA; pfam01472 1271864002268 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1271864002269 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1271864002270 putative catalytic cysteine [active] 1271864002271 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1271864002272 Int/Topo IB signature motif; other site 1271864002273 hypothetical protein; Region: PHA00626 1271864002274 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1271864002275 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1271864002276 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1271864002277 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 1271864002278 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 1271864002279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1271864002280 ERF superfamily; Region: ERF; pfam04404 1271864002281 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 1271864002282 hypothetical protein; Region: PHA01516 1271864002283 Antirestriction protein Ral; Region: Ral; pfam11058 1271864002284 Superinfection exclusion protein B; Region: SieB; pfam14163 1271864002285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864002286 sequence-specific DNA binding site [nucleotide binding]; other site 1271864002287 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1271864002288 salt bridge; other site 1271864002289 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1271864002290 Catalytic site [active] 1271864002291 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1271864002292 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1271864002293 Protein of unknown function (DUF2740); Region: DUF2740; pfam10872 1271864002294 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1271864002295 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1271864002296 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1271864002297 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1271864002298 Walker A motif; other site 1271864002299 ATP binding site [chemical binding]; other site 1271864002300 Walker B motif; other site 1271864002301 DNA binding loops [nucleotide binding] 1271864002302 NinB protein; Region: NinB; pfam05772 1271864002303 NINE Protein; Region: NinE; pfam05322 1271864002304 hypothetical protein; Region: PHA01519 1271864002305 NinF protein; Region: NinF; pfam05810 1271864002306 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1271864002307 Phage NinH protein; Region: Phage_NinH; pfam06322 1271864002308 Antitermination protein; Region: Antiterm; pfam03589 1271864002309 Antitermination protein; Region: Antiterm; pfam03589 1271864002310 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1271864002311 catalytic residues [active] 1271864002312 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1271864002313 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1271864002314 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1271864002315 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 1271864002316 hypothetical protein; Region: PHA00781 1271864002317 Terminase-like family; Region: Terminase_6; pfam03237 1271864002318 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565 1271864002319 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 1271864002320 coat protein; Region: PHA01511 1271864002321 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1271864002322 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 1271864002323 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 1271864002324 Protein of unknown function (DUF812); Region: DUF812; pfam05667 1271864002325 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 1271864002326 Arc-like DNA binding domain; Region: Arc; pfam03869 1271864002327 Head binding; Region: Head_binding; pfam09008 1271864002328 Salmonella phage P22 tail-spike; Region: PhageP22-tail; pfam09251 1271864002329 O-antigen conversion protein C; Region: PHA01514 1271864002330 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1271864002331 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1271864002332 Ligand binding site; other site 1271864002333 Putative Catalytic site; other site 1271864002334 DXD motif; other site 1271864002335 Predicted membrane protein [Function unknown]; Region: COG2246 1271864002336 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1271864002337 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1271864002338 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1271864002339 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1271864002340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002341 putative substrate translocation pore; other site 1271864002342 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1271864002343 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1271864002344 substrate binding site [chemical binding]; other site 1271864002345 ligand binding site [chemical binding]; other site 1271864002346 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 1271864002347 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1271864002348 hypothetical protein; Provisional; Region: PRK14812 1271864002349 substrate binding site [chemical binding]; other site 1271864002350 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1271864002351 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1271864002352 transcriptional activator TtdR; Provisional; Region: PRK09801 1271864002353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864002354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1271864002355 putative effector binding pocket; other site 1271864002356 putative dimerization interface [polypeptide binding]; other site 1271864002357 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1271864002358 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864002359 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864002360 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 1271864002361 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 1271864002362 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864002363 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864002364 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864002365 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 1271864002366 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864002367 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864002368 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1271864002369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1271864002370 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1271864002371 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864002372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1271864002373 DNA binding site [nucleotide binding] 1271864002374 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1271864002375 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1271864002376 DNA binding residues [nucleotide binding] 1271864002377 dimerization interface [polypeptide binding]; other site 1271864002378 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1271864002379 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1271864002380 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1271864002381 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1271864002382 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1271864002383 metal-binding site [ion binding] 1271864002384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1271864002385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864002386 motif II; other site 1271864002387 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1271864002388 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1271864002389 DNA binding residues [nucleotide binding] 1271864002390 dimer interface [polypeptide binding]; other site 1271864002391 copper binding site [ion binding]; other site 1271864002392 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1271864002393 metal-binding site [ion binding] 1271864002394 putative sialic acid transporter; Region: 2A0112; TIGR00891 1271864002395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002396 putative substrate translocation pore; other site 1271864002397 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1271864002398 DNA methylase; Region: N6_N4_Mtase; cl17433 1271864002399 DNA methylase; Region: N6_N4_Mtase; pfam01555 1271864002400 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1271864002401 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1271864002402 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1271864002403 VRR-NUC domain; Region: VRR_NUC; pfam08774 1271864002404 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1271864002405 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1271864002406 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1271864002407 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1271864002408 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864002409 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1271864002410 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864002411 N-terminal plug; other site 1271864002412 ligand-binding site [chemical binding]; other site 1271864002413 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1271864002414 hypothetical protein; Provisional; Region: PRK09929 1271864002415 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1271864002416 Propionate catabolism activator; Region: PrpR_N; pfam06506 1271864002417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864002418 Walker A motif; other site 1271864002419 ATP binding site [chemical binding]; other site 1271864002420 Walker B motif; other site 1271864002421 arginine finger; other site 1271864002422 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1271864002423 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1271864002424 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1271864002425 tetramer interface [polypeptide binding]; other site 1271864002426 active site 1271864002427 Mg2+/Mn2+ binding site [ion binding]; other site 1271864002428 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1271864002429 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1271864002430 dimer interface [polypeptide binding]; other site 1271864002431 active site 1271864002432 citrylCoA binding site [chemical binding]; other site 1271864002433 oxalacetate/citrate binding site [chemical binding]; other site 1271864002434 coenzyme A binding site [chemical binding]; other site 1271864002435 catalytic triad [active] 1271864002436 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1271864002437 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1271864002438 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1271864002439 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1271864002440 acyl-activating enzyme (AAE) consensus motif; other site 1271864002441 AMP binding site [chemical binding]; other site 1271864002442 active site 1271864002443 CoA binding site [chemical binding]; other site 1271864002444 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1271864002445 dimer interface [polypeptide binding]; other site 1271864002446 active site 1271864002447 Schiff base residues; other site 1271864002448 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1271864002449 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1271864002450 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1271864002451 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1271864002452 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1271864002453 ligand binding site [chemical binding]; other site 1271864002454 flexible hinge region; other site 1271864002455 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1271864002456 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1271864002457 microcin B17 transporter; Reviewed; Region: PRK11098 1271864002458 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1271864002459 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1271864002460 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1271864002461 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1271864002462 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1271864002463 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1271864002464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1271864002465 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1271864002466 drug efflux system protein MdtG; Provisional; Region: PRK09874 1271864002467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002468 putative substrate translocation pore; other site 1271864002469 anti-RssB factor; Provisional; Region: PRK10244 1271864002470 hypothetical protein; Provisional; Region: PRK11505 1271864002471 psiF repeat; Region: PsiF_repeat; pfam07769 1271864002472 psiF repeat; Region: PsiF_repeat; pfam07769 1271864002473 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1271864002474 MASE2 domain; Region: MASE2; pfam05230 1271864002475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864002476 metal binding site [ion binding]; metal-binding site 1271864002477 active site 1271864002478 I-site; other site 1271864002479 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1271864002480 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1271864002481 hypothetical protein; Validated; Region: PRK00124 1271864002482 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1271864002483 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1271864002484 ADP binding site [chemical binding]; other site 1271864002485 magnesium binding site [ion binding]; other site 1271864002486 putative shikimate binding site; other site 1271864002487 hypothetical protein; Provisional; Region: PRK10380 1271864002488 hypothetical protein; Provisional; Region: PRK10481 1271864002489 hypothetical protein; Provisional; Region: PRK10579 1271864002490 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1271864002491 fructokinase; Reviewed; Region: PRK09557 1271864002492 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864002493 nucleotide binding site [chemical binding]; other site 1271864002494 MFS transport protein AraJ; Provisional; Region: PRK10091 1271864002495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002496 putative substrate translocation pore; other site 1271864002497 exonuclease subunit SbcC; Provisional; Region: PRK10246 1271864002498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864002499 Walker A/P-loop; other site 1271864002500 ATP binding site [chemical binding]; other site 1271864002501 Q-loop/lid; other site 1271864002502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864002503 ABC transporter signature motif; other site 1271864002504 Walker B; other site 1271864002505 D-loop; other site 1271864002506 H-loop/switch region; other site 1271864002507 exonuclease subunit SbcD; Provisional; Region: PRK10966 1271864002508 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1271864002509 active site 1271864002510 metal binding site [ion binding]; metal-binding site 1271864002511 DNA binding site [nucleotide binding] 1271864002512 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1271864002513 transcriptional regulator PhoB; Provisional; Region: PRK10161 1271864002514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864002515 active site 1271864002516 phosphorylation site [posttranslational modification] 1271864002517 intermolecular recognition site; other site 1271864002518 dimerization interface [polypeptide binding]; other site 1271864002519 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864002520 DNA binding site [nucleotide binding] 1271864002521 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1271864002522 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1271864002523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864002524 putative active site [active] 1271864002525 heme pocket [chemical binding]; other site 1271864002526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864002527 dimer interface [polypeptide binding]; other site 1271864002528 phosphorylation site [posttranslational modification] 1271864002529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864002530 ATP binding site [chemical binding]; other site 1271864002531 Mg2+ binding site [ion binding]; other site 1271864002532 G-X-G motif; other site 1271864002533 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1271864002534 putative proline-specific permease; Provisional; Region: proY; PRK10580 1271864002535 maltodextrin glucosidase; Provisional; Region: PRK10785 1271864002536 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1271864002537 homodimer interface [polypeptide binding]; other site 1271864002538 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1271864002539 active site 1271864002540 homodimer interface [polypeptide binding]; other site 1271864002541 catalytic site [active] 1271864002542 peroxidase; Provisional; Region: PRK15000 1271864002543 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1271864002544 dimer interface [polypeptide binding]; other site 1271864002545 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1271864002546 catalytic triad [active] 1271864002547 peroxidatic and resolving cysteines [active] 1271864002548 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1271864002549 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1271864002550 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1271864002551 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1271864002552 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1271864002553 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1271864002554 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1271864002555 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1271864002556 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1271864002557 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1271864002558 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1271864002559 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1271864002560 Protein export membrane protein; Region: SecD_SecF; pfam02355 1271864002561 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1271864002562 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1271864002563 Predicted transcriptional regulator [Transcription]; Region: COG2378 1271864002564 HTH domain; Region: HTH_11; pfam08279 1271864002565 WYL domain; Region: WYL; pfam13280 1271864002566 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1271864002567 active site 1271864002568 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1271864002569 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1271864002570 hypothetical protein; Provisional; Region: PRK11530 1271864002571 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1271864002572 ATP cone domain; Region: ATP-cone; pfam03477 1271864002573 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1271864002574 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1271864002575 catalytic motif [active] 1271864002576 Zn binding site [ion binding]; other site 1271864002577 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1271864002578 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1271864002579 homopentamer interface [polypeptide binding]; other site 1271864002580 active site 1271864002581 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1271864002582 putative RNA binding site [nucleotide binding]; other site 1271864002583 thiamine monophosphate kinase; Provisional; Region: PRK05731 1271864002584 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1271864002585 ATP binding site [chemical binding]; other site 1271864002586 dimerization interface [polypeptide binding]; other site 1271864002587 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1271864002588 tetramer interfaces [polypeptide binding]; other site 1271864002589 binuclear metal-binding site [ion binding]; other site 1271864002590 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864002591 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864002592 active site 1271864002593 catalytic tetrad [active] 1271864002594 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1271864002595 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1271864002596 TPP-binding site; other site 1271864002597 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1271864002598 PYR/PP interface [polypeptide binding]; other site 1271864002599 dimer interface [polypeptide binding]; other site 1271864002600 TPP binding site [chemical binding]; other site 1271864002601 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1271864002602 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1271864002603 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1271864002604 substrate binding pocket [chemical binding]; other site 1271864002605 chain length determination region; other site 1271864002606 substrate-Mg2+ binding site; other site 1271864002607 catalytic residues [active] 1271864002608 aspartate-rich region 1; other site 1271864002609 active site lid residues [active] 1271864002610 aspartate-rich region 2; other site 1271864002611 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1271864002612 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1271864002613 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1271864002614 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1271864002615 Ligand Binding Site [chemical binding]; other site 1271864002616 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1271864002617 active site residue [active] 1271864002618 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1271864002619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864002620 dimer interface [polypeptide binding]; other site 1271864002621 conserved gate region; other site 1271864002622 putative PBP binding loops; other site 1271864002623 ABC-ATPase subunit interface; other site 1271864002624 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1271864002625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864002626 dimer interface [polypeptide binding]; other site 1271864002627 conserved gate region; other site 1271864002628 putative PBP binding loops; other site 1271864002629 ABC-ATPase subunit interface; other site 1271864002630 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1271864002631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864002632 Walker A/P-loop; other site 1271864002633 ATP binding site [chemical binding]; other site 1271864002634 Q-loop/lid; other site 1271864002635 ABC transporter signature motif; other site 1271864002636 Walker B; other site 1271864002637 D-loop; other site 1271864002638 H-loop/switch region; other site 1271864002639 TOBE domain; Region: TOBE_2; pfam08402 1271864002640 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1271864002641 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1271864002642 transcriptional regulator protein; Region: phnR; TIGR03337 1271864002643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864002644 DNA-binding site [nucleotide binding]; DNA binding site 1271864002645 UTRA domain; Region: UTRA; pfam07702 1271864002646 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 1271864002647 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864002648 catalytic residue [active] 1271864002649 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1271864002650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864002651 motif II; other site 1271864002652 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1271864002653 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1271864002654 conserved cys residue [active] 1271864002655 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1271864002656 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1271864002657 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1271864002658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1271864002659 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1271864002660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864002662 putative substrate translocation pore; other site 1271864002663 Sel1-like repeats; Region: SEL1; smart00671 1271864002664 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864002665 Sel1 repeat; Region: Sel1; pfam08238 1271864002666 Sel1-like repeats; Region: SEL1; smart00671 1271864002667 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864002668 Sel1-like repeats; Region: SEL1; smart00671 1271864002669 Sel1-like repeats; Region: SEL1; smart00671 1271864002670 Sel1-like repeats; Region: SEL1; smart00671 1271864002671 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1271864002672 UbiA prenyltransferase family; Region: UbiA; pfam01040 1271864002673 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1271864002674 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1271864002675 Subunit I/III interface [polypeptide binding]; other site 1271864002676 Subunit III/IV interface [polypeptide binding]; other site 1271864002677 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1271864002678 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1271864002679 D-pathway; other site 1271864002680 Putative ubiquinol binding site [chemical binding]; other site 1271864002681 Low-spin heme (heme b) binding site [chemical binding]; other site 1271864002682 Putative water exit pathway; other site 1271864002683 Binuclear center (heme o3/CuB) [ion binding]; other site 1271864002684 K-pathway; other site 1271864002685 Putative proton exit pathway; other site 1271864002686 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1271864002687 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1271864002688 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1271864002689 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1271864002690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002691 putative substrate translocation pore; other site 1271864002692 hypothetical protein; Provisional; Region: PRK11627 1271864002693 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1271864002694 transcriptional regulator BolA; Provisional; Region: PRK11628 1271864002695 trigger factor; Provisional; Region: tig; PRK01490 1271864002696 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1271864002697 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1271864002698 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1271864002699 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1271864002700 oligomer interface [polypeptide binding]; other site 1271864002701 active site residues [active] 1271864002702 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1271864002703 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1271864002704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864002705 Walker A motif; other site 1271864002706 ATP binding site [chemical binding]; other site 1271864002707 Walker B motif; other site 1271864002708 Iron permease FTR1 family; Region: FTR1; cl00475 1271864002709 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1271864002710 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1271864002711 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1271864002712 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1271864002713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864002714 Walker A motif; other site 1271864002715 ATP binding site [chemical binding]; other site 1271864002716 Walker B motif; other site 1271864002717 arginine finger; other site 1271864002718 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1271864002719 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1271864002720 IHF dimer interface [polypeptide binding]; other site 1271864002721 IHF - DNA interface [nucleotide binding]; other site 1271864002722 periplasmic folding chaperone; Provisional; Region: PRK10788 1271864002723 SurA N-terminal domain; Region: SurA_N_3; cl07813 1271864002724 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1271864002725 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1271864002726 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1271864002727 active site 1271864002728 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1271864002729 Ligand Binding Site [chemical binding]; other site 1271864002730 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1271864002731 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1271864002732 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1271864002733 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1271864002734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864002735 active site 1271864002736 motif I; other site 1271864002737 motif II; other site 1271864002738 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1271864002739 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1271864002740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864002741 catalytic residue [active] 1271864002742 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1271864002743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864002744 putative DNA binding site [nucleotide binding]; other site 1271864002745 putative Zn2+ binding site [ion binding]; other site 1271864002746 AsnC family; Region: AsnC_trans_reg; pfam01037 1271864002747 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1271864002748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864002749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864002750 Walker A/P-loop; other site 1271864002751 ATP binding site [chemical binding]; other site 1271864002752 Q-loop/lid; other site 1271864002753 ABC transporter signature motif; other site 1271864002754 Walker B; other site 1271864002755 D-loop; other site 1271864002756 H-loop/switch region; other site 1271864002757 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1271864002758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864002759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864002760 Walker A/P-loop; other site 1271864002761 ATP binding site [chemical binding]; other site 1271864002762 Q-loop/lid; other site 1271864002763 ABC transporter signature motif; other site 1271864002764 Walker B; other site 1271864002765 D-loop; other site 1271864002766 H-loop/switch region; other site 1271864002767 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1271864002768 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1271864002769 ammonium transporter; Provisional; Region: PRK10666 1271864002770 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1271864002771 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1271864002772 active site 1271864002773 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1271864002774 catalytic triad [active] 1271864002775 dimer interface [polypeptide binding]; other site 1271864002776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1271864002777 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1271864002778 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1271864002779 DNA binding site [nucleotide binding] 1271864002780 active site 1271864002781 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1271864002782 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1271864002783 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864002784 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1271864002785 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1271864002786 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1271864002787 maltose O-acetyltransferase; Provisional; Region: PRK10092 1271864002788 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1271864002789 active site 1271864002790 substrate binding site [chemical binding]; other site 1271864002791 trimer interface [polypeptide binding]; other site 1271864002792 CoA binding site [chemical binding]; other site 1271864002793 gene expression modulator; Provisional; Region: PRK10945 1271864002794 Hha toxicity attenuator; Provisional; Region: PRK10667 1271864002795 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1271864002796 Protein export membrane protein; Region: SecD_SecF; cl14618 1271864002797 Protein export membrane protein; Region: SecD_SecF; cl14618 1271864002798 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1271864002799 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864002800 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1271864002801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864002802 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1271864002803 hypothetical protein; Provisional; Region: PRK11281 1271864002804 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1271864002805 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1271864002806 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864002807 hypothetical protein; Provisional; Region: PRK11038 1271864002808 primosomal replication protein N''; Provisional; Region: PRK10093 1271864002809 hypothetical protein; Provisional; Region: PRK10527 1271864002810 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864002811 active site 1271864002812 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1271864002813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864002814 Walker A motif; other site 1271864002815 ATP binding site [chemical binding]; other site 1271864002816 Walker B motif; other site 1271864002817 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1271864002818 arginine finger; other site 1271864002819 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1271864002820 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1271864002821 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1271864002822 hypothetical protein; Validated; Region: PRK00153 1271864002823 recombination protein RecR; Reviewed; Region: recR; PRK00076 1271864002824 RecR protein; Region: RecR; pfam02132 1271864002825 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1271864002826 putative active site [active] 1271864002827 putative metal-binding site [ion binding]; other site 1271864002828 tetramer interface [polypeptide binding]; other site 1271864002829 heat shock protein 90; Provisional; Region: PRK05218 1271864002830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864002831 ATP binding site [chemical binding]; other site 1271864002832 Mg2+ binding site [ion binding]; other site 1271864002833 G-X-G motif; other site 1271864002834 adenylate kinase; Reviewed; Region: adk; PRK00279 1271864002835 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1271864002836 AMP-binding site [chemical binding]; other site 1271864002837 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1271864002838 ferrochelatase; Reviewed; Region: hemH; PRK00035 1271864002839 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1271864002840 C-terminal domain interface [polypeptide binding]; other site 1271864002841 active site 1271864002842 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1271864002843 active site 1271864002844 N-terminal domain interface [polypeptide binding]; other site 1271864002845 inosine/guanosine kinase; Provisional; Region: PRK15074 1271864002846 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864002847 putative cation:proton antiport protein; Provisional; Region: PRK10669 1271864002848 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1271864002849 TrkA-N domain; Region: TrkA_N; pfam02254 1271864002850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864002852 putative substrate translocation pore; other site 1271864002853 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1271864002854 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1271864002855 active site 1271864002856 metal binding site [ion binding]; metal-binding site 1271864002857 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1271864002858 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1271864002859 putative deacylase active site [active] 1271864002860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1271864002861 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1271864002862 copper exporting ATPase; Provisional; Region: copA; PRK10671 1271864002863 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1271864002864 metal-binding site [ion binding] 1271864002865 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1271864002866 metal-binding site [ion binding] 1271864002867 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1271864002868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864002869 motif II; other site 1271864002870 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1271864002871 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1271864002872 DNA binding residues [nucleotide binding] 1271864002873 dimer interface [polypeptide binding]; other site 1271864002874 copper binding site [ion binding]; other site 1271864002875 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1271864002876 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1271864002877 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1271864002878 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1271864002879 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1271864002880 Walker A/P-loop; other site 1271864002881 ATP binding site [chemical binding]; other site 1271864002882 Q-loop/lid; other site 1271864002883 ABC transporter signature motif; other site 1271864002884 Walker B; other site 1271864002885 D-loop; other site 1271864002886 H-loop/switch region; other site 1271864002887 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1271864002888 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1271864002889 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1271864002890 oxidoreductase; Provisional; Region: PRK08017 1271864002891 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1271864002892 NADP binding site [chemical binding]; other site 1271864002893 active site 1271864002894 steroid binding site; other site 1271864002895 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1271864002896 active site 1271864002897 catalytic triad [active] 1271864002898 oxyanion hole [active] 1271864002899 switch loop; other site 1271864002900 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1271864002901 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1271864002902 Walker A/P-loop; other site 1271864002903 ATP binding site [chemical binding]; other site 1271864002904 Q-loop/lid; other site 1271864002905 ABC transporter signature motif; other site 1271864002906 Walker B; other site 1271864002907 D-loop; other site 1271864002908 H-loop/switch region; other site 1271864002909 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1271864002910 FtsX-like permease family; Region: FtsX; pfam02687 1271864002911 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864002912 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1271864002913 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1271864002914 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1271864002915 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1271864002916 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1271864002917 Walker A/P-loop; other site 1271864002918 ATP binding site [chemical binding]; other site 1271864002919 Q-loop/lid; other site 1271864002920 ABC transporter signature motif; other site 1271864002921 Walker B; other site 1271864002922 D-loop; other site 1271864002923 H-loop/switch region; other site 1271864002924 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1271864002925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864002926 dimer interface [polypeptide binding]; other site 1271864002927 conserved gate region; other site 1271864002928 ABC-ATPase subunit interface; other site 1271864002929 Predicted ATPase [General function prediction only]; Region: COG2603 1271864002930 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1271864002931 active site residue [active] 1271864002932 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1271864002933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864002934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864002935 dimerization interface [polypeptide binding]; other site 1271864002936 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1271864002937 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1271864002938 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1271864002939 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1271864002940 Bacterial transcriptional regulator; Region: IclR; pfam01614 1271864002941 glyoxylate carboligase; Provisional; Region: PRK11269 1271864002942 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1271864002943 PYR/PP interface [polypeptide binding]; other site 1271864002944 dimer interface [polypeptide binding]; other site 1271864002945 TPP binding site [chemical binding]; other site 1271864002946 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1271864002947 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1271864002948 TPP-binding site [chemical binding]; other site 1271864002949 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1271864002950 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1271864002951 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1271864002952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864002953 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864002954 putative substrate translocation pore; other site 1271864002955 allantoinase; Provisional; Region: PRK08044 1271864002956 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1271864002957 active site 1271864002958 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1271864002959 glycerate kinase II; Provisional; Region: PRK09932 1271864002960 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1271864002961 Mif2/CENP-C like; Region: Mif2; pfam11699 1271864002962 Cupin domain; Region: Cupin_2; pfam07883 1271864002963 allantoate amidohydrolase; Region: AllC; TIGR03176 1271864002964 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1271864002965 active site 1271864002966 metal binding site [ion binding]; metal-binding site 1271864002967 dimer interface [polypeptide binding]; other site 1271864002968 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1271864002969 membrane protein FdrA; Validated; Region: PRK06091 1271864002970 CoA binding domain; Region: CoA_binding; pfam02629 1271864002971 CoA-ligase; Region: Ligase_CoA; pfam00549 1271864002972 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1271864002973 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1271864002974 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1271864002975 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1271864002976 putative substrate binding site [chemical binding]; other site 1271864002977 nucleotide binding site [chemical binding]; other site 1271864002978 nucleotide binding site [chemical binding]; other site 1271864002979 homodimer interface [polypeptide binding]; other site 1271864002980 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1271864002981 ATP-grasp domain; Region: ATP-grasp; pfam02222 1271864002982 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1271864002983 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1271864002984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1271864002985 putative active site [active] 1271864002986 putative metal binding site [ion binding]; other site 1271864002987 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1271864002988 substrate binding site [chemical binding]; other site 1271864002989 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1271864002990 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1271864002991 active site 1271864002992 HIGH motif; other site 1271864002993 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1271864002994 KMSKS motif; other site 1271864002995 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1271864002996 tRNA binding surface [nucleotide binding]; other site 1271864002997 anticodon binding site; other site 1271864002998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 1271864002999 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 1271864003000 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1271864003001 ribosome-associated protein; Provisional; Region: PRK11507 1271864003002 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1271864003003 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1271864003004 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1271864003005 homodimer interface [polypeptide binding]; other site 1271864003006 NADP binding site [chemical binding]; other site 1271864003007 substrate binding site [chemical binding]; other site 1271864003008 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1271864003009 fimbrial protein FimI; Provisional; Region: PRK15200 1271864003010 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1271864003011 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864003012 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864003013 outer membrane usher protein FimD; Provisional; Region: PRK15198 1271864003014 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864003015 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864003016 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864003017 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1271864003018 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1271864003019 transcriptional regulator FimZ; Provisional; Region: PRK09935 1271864003020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864003021 active site 1271864003022 phosphorylation site [posttranslational modification] 1271864003023 intermolecular recognition site; other site 1271864003024 dimerization interface [polypeptide binding]; other site 1271864003025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864003026 DNA binding residues [nucleotide binding] 1271864003027 dimerization interface [polypeptide binding]; other site 1271864003028 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 1271864003029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864003030 DNA binding residues [nucleotide binding] 1271864003031 dimerization interface [polypeptide binding]; other site 1271864003032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1271864003033 Transposase; Region: HTH_Tnp_1; pfam01527 1271864003034 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1271864003035 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1271864003036 Ligand binding site; other site 1271864003037 Putative Catalytic site; other site 1271864003038 DXD motif; other site 1271864003039 Predicted membrane protein [Function unknown]; Region: COG2246 1271864003040 GtrA-like protein; Region: GtrA; pfam04138 1271864003041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864003042 ATP binding site [chemical binding]; other site 1271864003043 Mg2+ binding site [ion binding]; other site 1271864003044 G-X-G motif; other site 1271864003045 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1271864003046 Cupin; Region: Cupin_6; pfam12852 1271864003047 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1271864003048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864003049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864003050 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1271864003051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864003052 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1271864003053 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864003054 Predicted membrane protein [Function unknown]; Region: COG3059 1271864003055 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1271864003056 phenylalanine transporter; Provisional; Region: PRK10249 1271864003057 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1271864003058 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864003059 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1271864003060 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1271864003061 active site 1271864003062 oxyanion hole [active] 1271864003063 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1271864003064 catalytic triad [active] 1271864003065 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1271864003066 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1271864003067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864003068 ATP binding site [chemical binding]; other site 1271864003069 Walker B motif; other site 1271864003070 arginine finger; other site 1271864003071 Transcriptional antiterminator [Transcription]; Region: COG3933 1271864003072 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1271864003073 active pocket/dimerization site; other site 1271864003074 active site 1271864003075 phosphorylation site [posttranslational modification] 1271864003076 PRD domain; Region: PRD; pfam00874 1271864003077 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1271864003078 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1271864003079 putative active site [active] 1271864003080 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1271864003081 dimer interface [polypeptide binding]; other site 1271864003082 active site 1271864003083 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1271864003084 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1271864003085 dimer interface [polypeptide binding]; other site 1271864003086 active site 1271864003087 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1271864003088 dimer interface [polypeptide binding]; other site 1271864003089 active site 1271864003090 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1271864003091 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1271864003092 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1271864003093 active site 1271864003094 phosphorylation site [posttranslational modification] 1271864003095 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1271864003096 active pocket/dimerization site; other site 1271864003097 active site 1271864003098 phosphorylation site [posttranslational modification] 1271864003099 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1271864003100 dimer interface [polypeptide binding]; other site 1271864003101 FMN binding site [chemical binding]; other site 1271864003102 hypothetical protein; Provisional; Region: PRK10250 1271864003103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1271864003104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864003105 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1271864003106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864003107 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1271864003108 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1271864003109 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1271864003110 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1271864003111 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1271864003112 outer membrane receptor FepA; Provisional; Region: PRK13524 1271864003113 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864003114 N-terminal plug; other site 1271864003115 ligand-binding site [chemical binding]; other site 1271864003116 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1271864003117 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1271864003118 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1271864003119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1271864003120 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1271864003121 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1271864003122 acyl-activating enzyme (AAE) consensus motif; other site 1271864003123 AMP binding site [chemical binding]; other site 1271864003124 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1271864003125 LPS O-antigen length regulator; Provisional; Region: PRK10381 1271864003126 Chain length determinant protein; Region: Wzz; pfam02706 1271864003127 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1271864003128 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1271864003129 Walker A/P-loop; other site 1271864003130 ATP binding site [chemical binding]; other site 1271864003131 Q-loop/lid; other site 1271864003132 ABC transporter signature motif; other site 1271864003133 Walker B; other site 1271864003134 D-loop; other site 1271864003135 H-loop/switch region; other site 1271864003136 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1271864003137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864003138 ABC-ATPase subunit interface; other site 1271864003139 dimer interface [polypeptide binding]; other site 1271864003140 putative PBP binding regions; other site 1271864003141 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1271864003142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864003143 ABC-ATPase subunit interface; other site 1271864003144 dimer interface [polypeptide binding]; other site 1271864003145 putative PBP binding regions; other site 1271864003146 enterobactin exporter EntS; Provisional; Region: PRK10489 1271864003147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864003148 putative substrate translocation pore; other site 1271864003149 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1271864003150 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1271864003151 siderophore binding site; other site 1271864003152 isochorismate synthase EntC; Provisional; Region: PRK15016 1271864003153 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1271864003154 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1271864003155 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1271864003156 acyl-activating enzyme (AAE) consensus motif; other site 1271864003157 active site 1271864003158 AMP binding site [chemical binding]; other site 1271864003159 substrate binding site [chemical binding]; other site 1271864003160 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1271864003161 hydrophobic substrate binding pocket; other site 1271864003162 Isochorismatase family; Region: Isochorismatase; pfam00857 1271864003163 active site 1271864003164 conserved cis-peptide bond; other site 1271864003165 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1271864003166 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1271864003167 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1271864003168 putative NAD(P) binding site [chemical binding]; other site 1271864003169 active site 1271864003170 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1271864003171 CoenzymeA binding site [chemical binding]; other site 1271864003172 subunit interaction site [polypeptide binding]; other site 1271864003173 PHB binding site; other site 1271864003174 carbon starvation protein A; Provisional; Region: PRK15015 1271864003175 Carbon starvation protein CstA; Region: CstA; pfam02554 1271864003176 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1271864003177 Uncharacterized small protein [Function unknown]; Region: COG2879 1271864003178 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1271864003179 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1271864003180 putative active site [active] 1271864003181 metal binding site [ion binding]; metal-binding site 1271864003182 methionine aminotransferase; Validated; Region: PRK09082 1271864003183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864003184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864003185 homodimer interface [polypeptide binding]; other site 1271864003186 catalytic residue [active] 1271864003187 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1271864003188 ParB-like nuclease domain; Region: ParBc; pfam02195 1271864003189 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1271864003190 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1271864003191 Active Sites [active] 1271864003192 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1271864003193 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1271864003194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864003195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864003196 dimerization interface [polypeptide binding]; other site 1271864003197 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1271864003198 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1271864003199 dimerization domain [polypeptide binding]; other site 1271864003200 dimer interface [polypeptide binding]; other site 1271864003201 catalytic residues [active] 1271864003202 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1271864003203 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1271864003204 dimer interface [polypeptide binding]; other site 1271864003205 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1271864003206 catalytic triad [active] 1271864003207 peroxidatic and resolving cysteines [active] 1271864003208 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1271864003209 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1271864003210 catalytic residue [active] 1271864003211 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1271864003212 catalytic residues [active] 1271864003213 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864003214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864003215 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1271864003216 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1271864003217 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1271864003218 putative [4Fe-4S] binding site [ion binding]; other site 1271864003219 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864003220 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1271864003221 molybdopterin cofactor binding site; other site 1271864003222 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1271864003223 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1271864003224 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1271864003225 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1271864003226 Ligand Binding Site [chemical binding]; other site 1271864003227 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1271864003228 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1271864003229 NAD binding site [chemical binding]; other site 1271864003230 catalytic Zn binding site [ion binding]; other site 1271864003231 structural Zn binding site [ion binding]; other site 1271864003232 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1271864003233 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1271864003234 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1271864003235 B1 nucleotide binding pocket [chemical binding]; other site 1271864003236 B2 nucleotide binding pocket [chemical binding]; other site 1271864003237 CAS motifs; other site 1271864003238 active site 1271864003239 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1271864003240 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1271864003241 transmembrane helices; other site 1271864003242 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1271864003243 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1271864003244 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1271864003245 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1271864003246 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1271864003247 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1271864003248 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1271864003249 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1271864003250 putative active site [active] 1271864003251 (T/H)XGH motif; other site 1271864003252 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1271864003253 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864003254 putative active site [active] 1271864003255 heme pocket [chemical binding]; other site 1271864003256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864003257 ATP binding site [chemical binding]; other site 1271864003258 Mg2+ binding site [ion binding]; other site 1271864003259 G-X-G motif; other site 1271864003260 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1271864003261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864003262 active site 1271864003263 phosphorylation site [posttranslational modification] 1271864003264 intermolecular recognition site; other site 1271864003265 dimerization interface [polypeptide binding]; other site 1271864003266 Transcriptional regulator; Region: CitT; pfam12431 1271864003267 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1271864003268 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1271864003269 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1271864003270 cspA; Derived by automated computational analysis using gene prediction method: cmsearch. 1271864003271 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1271864003272 DNA-binding site [nucleotide binding]; DNA binding site 1271864003273 RNA-binding motif; other site 1271864003274 chromosome condensation membrane protein; Provisional; Region: PRK14196 1271864003275 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1271864003276 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1271864003277 putative active site [active] 1271864003278 catalytic triad [active] 1271864003279 putative dimer interface [polypeptide binding]; other site 1271864003280 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1271864003281 lipoyl synthase; Provisional; Region: PRK05481 1271864003282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864003283 FeS/SAM binding site; other site 1271864003284 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1271864003285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864003286 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1271864003287 substrate binding pocket [chemical binding]; other site 1271864003288 dimerization interface [polypeptide binding]; other site 1271864003289 lipoate-protein ligase B; Provisional; Region: PRK14342 1271864003290 hypothetical protein; Provisional; Region: PRK04998 1271864003291 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1271864003292 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1271864003293 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1271864003294 rare lipoprotein A; Provisional; Region: PRK10672 1271864003295 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1271864003296 Sporulation related domain; Region: SPOR; pfam05036 1271864003297 cell wall shape-determining protein; Provisional; Region: PRK10794 1271864003298 penicillin-binding protein 2; Provisional; Region: PRK10795 1271864003299 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1271864003300 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1271864003301 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1271864003302 ribosome-associated protein; Provisional; Region: PRK11538 1271864003303 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1271864003304 catalytic core [active] 1271864003305 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1271864003306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864003307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864003308 homodimer interface [polypeptide binding]; other site 1271864003309 catalytic residue [active] 1271864003310 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1271864003311 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1271864003312 active site 1271864003313 (T/H)XGH motif; other site 1271864003314 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1271864003315 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1271864003316 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1271864003317 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1271864003318 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1271864003319 HIGH motif; other site 1271864003320 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1271864003321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1271864003322 active site 1271864003323 KMSKS motif; other site 1271864003324 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1271864003325 tRNA binding surface [nucleotide binding]; other site 1271864003326 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1271864003327 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1271864003328 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1271864003329 Propionate catabolism activator; Region: PrpR_N; pfam06506 1271864003330 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1271864003331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864003332 Walker A motif; other site 1271864003333 ATP binding site [chemical binding]; other site 1271864003334 Walker B motif; other site 1271864003335 arginine finger; other site 1271864003336 hypothetical protein; Provisional; Region: PRK11032 1271864003337 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1271864003338 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864003339 Sel1-like repeats; Region: SEL1; smart00671 1271864003340 Sel1-like repeats; Region: SEL1; smart00671 1271864003341 Sel1-like repeats; Region: SEL1; smart00671 1271864003342 Sel1-like repeats; Region: SEL1; smart00671 1271864003343 Sel1-like repeats; Region: SEL1; smart00671 1271864003344 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1271864003345 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1271864003346 HSP70 interaction site [polypeptide binding]; other site 1271864003347 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1271864003348 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1271864003349 HSP70 interaction site [polypeptide binding]; other site 1271864003350 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1271864003351 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1271864003352 nucleotide binding site [chemical binding]; other site 1271864003353 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1271864003354 SBD interface [polypeptide binding]; other site 1271864003355 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1271864003356 active site 1271864003357 tetramer interface [polypeptide binding]; other site 1271864003358 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1271864003359 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1271864003360 Walker A/P-loop; other site 1271864003361 ATP binding site [chemical binding]; other site 1271864003362 Q-loop/lid; other site 1271864003363 ABC transporter signature motif; other site 1271864003364 Walker B; other site 1271864003365 D-loop; other site 1271864003366 H-loop/switch region; other site 1271864003367 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864003369 dimer interface [polypeptide binding]; other site 1271864003370 conserved gate region; other site 1271864003371 putative PBP binding loops; other site 1271864003372 ABC-ATPase subunit interface; other site 1271864003373 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864003374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864003375 dimer interface [polypeptide binding]; other site 1271864003376 conserved gate region; other site 1271864003377 putative PBP binding loops; other site 1271864003378 ABC-ATPase subunit interface; other site 1271864003379 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1271864003380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864003381 substrate binding pocket [chemical binding]; other site 1271864003382 membrane-bound complex binding site; other site 1271864003383 hinge residues; other site 1271864003384 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1271864003385 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1271864003386 putative active site [active] 1271864003387 catalytic triad [active] 1271864003388 putative dimer interface [polypeptide binding]; other site 1271864003389 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1271864003390 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1271864003391 Transporter associated domain; Region: CorC_HlyC; smart01091 1271864003392 metal-binding heat shock protein; Provisional; Region: PRK00016 1271864003393 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1271864003394 PhoH-like protein; Region: PhoH; pfam02562 1271864003395 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1271864003396 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1271864003397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864003398 FeS/SAM binding site; other site 1271864003399 TRAM domain; Region: TRAM; pfam01938 1271864003400 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1271864003401 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1271864003402 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1271864003403 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1271864003404 active site 1271864003405 dimer interface [polypeptide binding]; other site 1271864003406 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1271864003407 Ligand Binding Site [chemical binding]; other site 1271864003408 Molecular Tunnel; other site 1271864003409 UMP phosphatase; Provisional; Region: PRK10444 1271864003410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864003411 active site 1271864003412 motif I; other site 1271864003413 motif II; other site 1271864003414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864003415 MarR family; Region: MarR; pfam01047 1271864003416 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1271864003417 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864003418 nucleotide binding site [chemical binding]; other site 1271864003419 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1271864003420 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1271864003421 active site 1271864003422 dimer interface [polypeptide binding]; other site 1271864003423 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1271864003424 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1271864003425 active site 1271864003426 trimer interface [polypeptide binding]; other site 1271864003427 allosteric site; other site 1271864003428 active site lid [active] 1271864003429 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1271864003430 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1271864003431 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1271864003432 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1271864003433 active site turn [active] 1271864003434 phosphorylation site [posttranslational modification] 1271864003435 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1271864003436 HPr interaction site; other site 1271864003437 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1271864003438 active site 1271864003439 phosphorylation site [posttranslational modification] 1271864003440 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1271864003441 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1271864003442 active site 1271864003443 HIGH motif; other site 1271864003444 nucleotide binding site [chemical binding]; other site 1271864003445 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1271864003446 KMSKS motif; other site 1271864003447 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1271864003448 outer membrane porin, OprD family; Region: OprD; pfam03573 1271864003449 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1271864003450 YbfN-like lipoprotein; Region: YbfN; pfam13982 1271864003451 citrate-proton symporter; Provisional; Region: PRK15075 1271864003452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864003453 putative substrate translocation pore; other site 1271864003454 tricarballylate utilization protein B; Provisional; Region: PRK15033 1271864003455 tricarballylate dehydrogenase; Validated; Region: PRK08274 1271864003456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864003457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864003458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864003459 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1271864003460 putative dimerization interface [polypeptide binding]; other site 1271864003461 ferric uptake regulator; Provisional; Region: fur; PRK09462 1271864003462 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1271864003463 metal binding site 2 [ion binding]; metal-binding site 1271864003464 putative DNA binding helix; other site 1271864003465 metal binding site 1 [ion binding]; metal-binding site 1271864003466 dimer interface [polypeptide binding]; other site 1271864003467 structural Zn2+ binding site [ion binding]; other site 1271864003468 flavodoxin FldA; Validated; Region: PRK09267 1271864003469 LexA regulated protein; Provisional; Region: PRK11675 1271864003470 acyl-CoA esterase; Provisional; Region: PRK10673 1271864003471 PGAP1-like protein; Region: PGAP1; pfam07819 1271864003472 replication initiation regulator SeqA; Provisional; Region: PRK11187 1271864003473 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1271864003474 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1271864003475 active site 1271864003476 substrate binding site [chemical binding]; other site 1271864003477 metal binding site [ion binding]; metal-binding site 1271864003478 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1271864003479 putrescine transporter; Provisional; Region: potE; PRK10655 1271864003480 ornithine decarboxylase; Provisional; Region: PRK13578 1271864003481 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1271864003482 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1271864003483 homodimer interface [polypeptide binding]; other site 1271864003484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864003485 catalytic residue [active] 1271864003486 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1271864003487 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1271864003488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864003489 active site 1271864003490 phosphorylation site [posttranslational modification] 1271864003491 intermolecular recognition site; other site 1271864003492 dimerization interface [polypeptide binding]; other site 1271864003493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864003494 DNA binding site [nucleotide binding] 1271864003495 sensor protein KdpD; Provisional; Region: PRK10490 1271864003496 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1271864003497 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1271864003498 Ligand Binding Site [chemical binding]; other site 1271864003499 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1271864003500 GAF domain; Region: GAF_3; pfam13492 1271864003501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864003502 dimer interface [polypeptide binding]; other site 1271864003503 phosphorylation site [posttranslational modification] 1271864003504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864003505 ATP binding site [chemical binding]; other site 1271864003506 Mg2+ binding site [ion binding]; other site 1271864003507 G-X-G motif; other site 1271864003508 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1271864003509 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1271864003510 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1271864003511 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1271864003512 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1271864003513 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1271864003514 DNA photolyase; Region: DNA_photolyase; pfam00875 1271864003515 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1271864003516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864003517 putative substrate translocation pore; other site 1271864003518 POT family; Region: PTR2; pfam00854 1271864003519 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1271864003520 metal-binding protein; Provisional; Region: PRK10799 1271864003521 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1271864003522 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1271864003523 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1271864003524 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1271864003525 putative active site [active] 1271864003526 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1271864003527 active site 1271864003528 DNA binding site [nucleotide binding] 1271864003529 Int/Topo IB signature motif; other site 1271864003530 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1271864003531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1271864003532 UDP-galactopyranose mutase; Region: GLF; pfam03275 1271864003533 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1271864003534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864003535 active site 1271864003536 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1271864003537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1271864003538 putative ADP-binding pocket [chemical binding]; other site 1271864003539 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1271864003540 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1271864003541 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1271864003542 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1271864003543 Walker A/P-loop; other site 1271864003544 ATP binding site [chemical binding]; other site 1271864003545 Q-loop/lid; other site 1271864003546 ABC transporter signature motif; other site 1271864003547 Walker B; other site 1271864003548 D-loop; other site 1271864003549 H-loop/switch region; other site 1271864003550 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1271864003551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864003552 active site 1271864003553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864003554 active site 1271864003555 endonuclease VIII; Provisional; Region: PRK10445 1271864003556 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1271864003557 DNA binding site [nucleotide binding] 1271864003558 catalytic residue [active] 1271864003559 putative catalytic residues [active] 1271864003560 H2TH interface [polypeptide binding]; other site 1271864003561 intercalation triad [nucleotide binding]; other site 1271864003562 substrate specificity determining residue; other site 1271864003563 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1271864003564 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1271864003565 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1271864003566 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1271864003567 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1271864003568 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1271864003569 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1271864003570 dimer interface [polypeptide binding]; other site 1271864003571 active site 1271864003572 citrylCoA binding site [chemical binding]; other site 1271864003573 NADH binding [chemical binding]; other site 1271864003574 cationic pore residues; other site 1271864003575 oxalacetate/citrate binding site [chemical binding]; other site 1271864003576 coenzyme A binding site [chemical binding]; other site 1271864003577 catalytic triad [active] 1271864003578 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1271864003579 Iron-sulfur protein interface; other site 1271864003580 proximal quinone binding site [chemical binding]; other site 1271864003581 SdhD (CybS) interface [polypeptide binding]; other site 1271864003582 proximal heme binding site [chemical binding]; other site 1271864003583 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1271864003584 SdhC subunit interface [polypeptide binding]; other site 1271864003585 proximal heme binding site [chemical binding]; other site 1271864003586 cardiolipin binding site; other site 1271864003587 Iron-sulfur protein interface; other site 1271864003588 proximal quinone binding site [chemical binding]; other site 1271864003589 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1271864003590 L-aspartate oxidase; Provisional; Region: PRK06175 1271864003591 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1271864003592 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1271864003593 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1271864003594 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1271864003595 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1271864003596 TPP-binding site [chemical binding]; other site 1271864003597 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1271864003598 dimer interface [polypeptide binding]; other site 1271864003599 PYR/PP interface [polypeptide binding]; other site 1271864003600 TPP binding site [chemical binding]; other site 1271864003601 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1271864003602 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1271864003603 E3 interaction surface; other site 1271864003604 lipoyl attachment site [posttranslational modification]; other site 1271864003605 e3 binding domain; Region: E3_binding; pfam02817 1271864003606 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1271864003607 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1271864003608 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1271864003609 CoA-ligase; Region: Ligase_CoA; pfam00549 1271864003610 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1271864003611 CoA binding domain; Region: CoA_binding; smart00881 1271864003612 CoA-ligase; Region: Ligase_CoA; pfam00549 1271864003613 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1271864003614 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1271864003615 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1271864003616 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1271864003617 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 1271864003618 hypothetical protein; Provisional; Region: PRK10588 1271864003619 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1271864003620 active site 1271864003621 colicin uptake protein TolQ; Provisional; Region: PRK10801 1271864003622 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1271864003623 colicin uptake protein TolR; Provisional; Region: PRK11024 1271864003624 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1271864003625 TolA C-terminal; Region: TolA; pfam06519 1271864003626 translocation protein TolB; Provisional; Region: tolB; PRK03629 1271864003627 TolB amino-terminal domain; Region: TolB_N; pfam04052 1271864003628 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1271864003629 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1271864003630 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1271864003631 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1271864003632 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1271864003633 ligand binding site [chemical binding]; other site 1271864003634 tol-pal system protein YbgF; Provisional; Region: PRK10803 1271864003635 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1271864003636 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1271864003637 quinolinate synthetase; Provisional; Region: PRK09375 1271864003638 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1271864003639 zinc transporter ZitB; Provisional; Region: PRK03557 1271864003640 YbgS-like protein; Region: YbgS; pfam13985 1271864003641 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1271864003642 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1271864003643 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 1271864003644 fumarate hydratase; Provisional; Region: PRK06246 1271864003645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864003646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864003647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1271864003648 dimerization interface [polypeptide binding]; other site 1271864003649 cell density-dependent motility repressor; Provisional; Region: PRK10082 1271864003650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864003651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1271864003652 dimerization interface [polypeptide binding]; other site 1271864003653 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1271864003654 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1271864003655 transmembrane helices; other site 1271864003656 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1271864003657 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1271864003658 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1271864003659 active site 1271864003660 catalytic residues [active] 1271864003661 metal binding site [ion binding]; metal-binding site 1271864003662 homodimer binding site [polypeptide binding]; other site 1271864003663 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1271864003664 carboxyltransferase (CT) interaction site; other site 1271864003665 biotinylation site [posttranslational modification]; other site 1271864003666 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1271864003667 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1271864003668 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1271864003669 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864003670 dimer interface [polypeptide binding]; other site 1271864003671 putative PBP binding regions; other site 1271864003672 ABC-ATPase subunit interface; other site 1271864003673 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1271864003674 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1271864003675 Walker A/P-loop; other site 1271864003676 ATP binding site [chemical binding]; other site 1271864003677 Q-loop/lid; other site 1271864003678 ABC transporter signature motif; other site 1271864003679 Walker B; other site 1271864003680 D-loop; other site 1271864003681 H-loop/switch region; other site 1271864003682 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1271864003683 catalytic core [active] 1271864003684 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1271864003685 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1271864003686 active site 1271864003687 catalytic residues [active] 1271864003688 galactokinase; Provisional; Region: PRK05101 1271864003689 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1271864003690 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1271864003691 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1271864003692 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1271864003693 dimer interface [polypeptide binding]; other site 1271864003694 active site 1271864003695 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1271864003696 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1271864003697 NAD binding site [chemical binding]; other site 1271864003698 homodimer interface [polypeptide binding]; other site 1271864003699 active site 1271864003700 substrate binding site [chemical binding]; other site 1271864003701 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 1271864003702 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1271864003703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864003704 Walker A/P-loop; other site 1271864003705 ATP binding site [chemical binding]; other site 1271864003706 Q-loop/lid; other site 1271864003707 ABC transporter signature motif; other site 1271864003708 Walker B; other site 1271864003709 D-loop; other site 1271864003710 H-loop/switch region; other site 1271864003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864003712 Walker A/P-loop; other site 1271864003713 ATP binding site [chemical binding]; other site 1271864003714 Q-loop/lid; other site 1271864003715 ABC transporter signature motif; other site 1271864003716 Walker B; other site 1271864003717 D-loop; other site 1271864003718 H-loop/switch region; other site 1271864003719 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1271864003720 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1271864003721 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1271864003722 TOBE domain; Region: TOBE; pfam03459 1271864003723 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1271864003724 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1271864003725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864003726 substrate binding pocket [chemical binding]; other site 1271864003727 membrane-bound complex binding site; other site 1271864003728 hinge residues; other site 1271864003729 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1271864003730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864003731 dimer interface [polypeptide binding]; other site 1271864003732 conserved gate region; other site 1271864003733 putative PBP binding loops; other site 1271864003734 ABC-ATPase subunit interface; other site 1271864003735 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1271864003736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864003737 Walker A/P-loop; other site 1271864003738 ATP binding site [chemical binding]; other site 1271864003739 Q-loop/lid; other site 1271864003740 ABC transporter signature motif; other site 1271864003741 Walker B; other site 1271864003742 D-loop; other site 1271864003743 H-loop/switch region; other site 1271864003744 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1271864003745 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1271864003746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864003747 active site 1271864003748 motif I; other site 1271864003749 motif II; other site 1271864003750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864003751 6-phosphogluconolactonase; Provisional; Region: PRK11028 1271864003752 acyl-CoA thioesterase; Provisional; Region: PRK10531 1271864003753 putative pectinesterase; Region: PLN02432; cl01911 1271864003754 imidazolonepropionase; Validated; Region: PRK09356 1271864003755 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1271864003756 active site 1271864003757 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1271864003758 putative active site [active] 1271864003759 putative metal binding site [ion binding]; other site 1271864003760 histidine utilization repressor; Provisional; Region: PRK14999 1271864003761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864003762 DNA-binding site [nucleotide binding]; DNA binding site 1271864003763 UTRA domain; Region: UTRA; pfam07702 1271864003764 urocanate hydratase; Provisional; Region: PRK05414 1271864003765 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1271864003766 active sites [active] 1271864003767 tetramer interface [polypeptide binding]; other site 1271864003768 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1271864003769 substrate binding site [chemical binding]; other site 1271864003770 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1271864003771 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1271864003772 inhibitor-cofactor binding pocket; inhibition site 1271864003773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864003774 catalytic residue [active] 1271864003775 biotin synthase; Provisional; Region: PRK15108 1271864003776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864003777 FeS/SAM binding site; other site 1271864003778 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1271864003779 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1271864003780 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1271864003781 substrate-cofactor binding pocket; other site 1271864003782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864003783 catalytic residue [active] 1271864003784 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1271864003785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864003786 S-adenosylmethionine binding site [chemical binding]; other site 1271864003787 AAA domain; Region: AAA_26; pfam13500 1271864003788 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1271864003789 excinuclease ABC subunit B; Provisional; Region: PRK05298 1271864003790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864003791 ATP binding site [chemical binding]; other site 1271864003792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864003793 nucleotide binding region [chemical binding]; other site 1271864003794 ATP-binding site [chemical binding]; other site 1271864003795 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1271864003796 UvrB/uvrC motif; Region: UVR; pfam02151 1271864003797 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1271864003798 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1271864003799 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1271864003800 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1271864003801 Leucine-rich repeats; other site 1271864003802 Substrate binding site [chemical binding]; other site 1271864003803 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1271864003804 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1271864003805 putative substrate binding pocket [chemical binding]; other site 1271864003806 dimer interface [polypeptide binding]; other site 1271864003807 phosphate binding site [ion binding]; other site 1271864003808 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1271864003809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864003810 FeS/SAM binding site; other site 1271864003811 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1271864003812 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1271864003813 MPT binding site; other site 1271864003814 trimer interface [polypeptide binding]; other site 1271864003815 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1271864003816 trimer interface [polypeptide binding]; other site 1271864003817 dimer interface [polypeptide binding]; other site 1271864003818 putative active site [active] 1271864003819 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1271864003820 MoaE interaction surface [polypeptide binding]; other site 1271864003821 MoeB interaction surface [polypeptide binding]; other site 1271864003822 thiocarboxylated glycine; other site 1271864003823 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1271864003824 MoaE homodimer interface [polypeptide binding]; other site 1271864003825 MoaD interaction [polypeptide binding]; other site 1271864003826 active site residues [active] 1271864003827 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1271864003828 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1271864003829 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1271864003830 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1271864003831 Predicted integral membrane protein [Function unknown]; Region: COG0392 1271864003832 cardiolipin synthase 2; Provisional; Region: PRK11263 1271864003833 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1271864003834 putative active site [active] 1271864003835 catalytic site [active] 1271864003836 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1271864003837 putative active site [active] 1271864003838 catalytic site [active] 1271864003839 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1271864003840 putative catalytic site [active] 1271864003841 putative metal binding site [ion binding]; other site 1271864003842 putative phosphate binding site [ion binding]; other site 1271864003843 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1271864003844 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1271864003845 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1271864003846 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1271864003847 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1271864003848 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1271864003849 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1271864003850 Walker A/P-loop; other site 1271864003851 ATP binding site [chemical binding]; other site 1271864003852 Q-loop/lid; other site 1271864003853 ABC transporter signature motif; other site 1271864003854 Walker B; other site 1271864003855 D-loop; other site 1271864003856 H-loop/switch region; other site 1271864003857 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1271864003858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1271864003859 Walker A/P-loop; other site 1271864003860 ATP binding site [chemical binding]; other site 1271864003861 Q-loop/lid; other site 1271864003862 ABC transporter signature motif; other site 1271864003863 Walker B; other site 1271864003864 D-loop; other site 1271864003865 H-loop/switch region; other site 1271864003866 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1271864003867 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864003868 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864003869 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1271864003870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864003871 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1271864003872 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1271864003873 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1271864003874 ATP binding site [chemical binding]; other site 1271864003875 Mg++ binding site [ion binding]; other site 1271864003876 motif III; other site 1271864003877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864003878 nucleotide binding region [chemical binding]; other site 1271864003879 ATP-binding site [chemical binding]; other site 1271864003880 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1271864003881 DEAD_2; Region: DEAD_2; pfam06733 1271864003882 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1271864003883 glycosyl transferase family protein; Provisional; Region: PRK08136 1271864003884 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1271864003885 hypothetical protein; Provisional; Region: PRK10259 1271864003886 hypothetical protein; Provisional; Region: PRK11019 1271864003887 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1271864003888 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1271864003889 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1271864003890 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864003891 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1271864003892 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1271864003893 Walker A/P-loop; other site 1271864003894 ATP binding site [chemical binding]; other site 1271864003895 Q-loop/lid; other site 1271864003896 ABC transporter signature motif; other site 1271864003897 Walker B; other site 1271864003898 D-loop; other site 1271864003899 H-loop/switch region; other site 1271864003900 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864003901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864003902 dimer interface [polypeptide binding]; other site 1271864003903 conserved gate region; other site 1271864003904 putative PBP binding loops; other site 1271864003905 ABC-ATPase subunit interface; other site 1271864003906 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1271864003907 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864003908 substrate binding pocket [chemical binding]; other site 1271864003909 membrane-bound complex binding site; other site 1271864003910 hinge residues; other site 1271864003911 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1271864003912 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1271864003913 dimerization interface [polypeptide binding]; other site 1271864003914 DPS ferroxidase diiron center [ion binding]; other site 1271864003915 ion pore; other site 1271864003916 threonine and homoserine efflux system; Provisional; Region: PRK10532 1271864003917 EamA-like transporter family; Region: EamA; pfam00892 1271864003918 outer membrane protein X; Provisional; Region: ompX; PRK09408 1271864003919 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1271864003920 Sulfatase; Region: Sulfatase; pfam00884 1271864003921 manganese transport regulator MntR; Provisional; Region: PRK11050 1271864003922 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1271864003923 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1271864003924 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1271864003925 transmembrane helices; other site 1271864003926 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1271864003927 L,D-transpeptidase; Provisional; Region: PRK10260 1271864003928 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1271864003929 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1271864003930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864003931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864003932 Walker A/P-loop; other site 1271864003933 ATP binding site [chemical binding]; other site 1271864003934 ABC transporter signature motif; other site 1271864003935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864003936 Walker B; other site 1271864003937 ABC transporter; Region: ABC_tran_2; pfam12848 1271864003938 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864003939 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1271864003940 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1271864003941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864003942 active site 1271864003943 motif I; other site 1271864003944 motif II; other site 1271864003945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864003946 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1271864003947 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1271864003948 dimer interface [polypeptide binding]; other site 1271864003949 active site 1271864003950 glycine loop; other site 1271864003951 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1271864003952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864003953 FeS/SAM binding site; other site 1271864003954 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1271864003955 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1271864003956 ATP binding site [chemical binding]; other site 1271864003957 substrate interface [chemical binding]; other site 1271864003958 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1271864003959 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1271864003960 dimer interface [polypeptide binding]; other site 1271864003961 putative functional site; other site 1271864003962 putative MPT binding site; other site 1271864003963 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1271864003964 catalytic nucleophile [active] 1271864003965 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1271864003966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864003967 Walker A/P-loop; other site 1271864003968 ATP binding site [chemical binding]; other site 1271864003969 Q-loop/lid; other site 1271864003970 ABC transporter signature motif; other site 1271864003971 Walker B; other site 1271864003972 D-loop; other site 1271864003973 H-loop/switch region; other site 1271864003974 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1271864003975 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864003976 Walker A/P-loop; other site 1271864003977 ATP binding site [chemical binding]; other site 1271864003978 Q-loop/lid; other site 1271864003979 ABC transporter signature motif; other site 1271864003980 Walker B; other site 1271864003981 D-loop; other site 1271864003982 H-loop/switch region; other site 1271864003983 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1271864003984 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1271864003985 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1271864003986 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1271864003987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864003988 dimer interface [polypeptide binding]; other site 1271864003989 conserved gate region; other site 1271864003990 putative PBP binding loops; other site 1271864003991 ABC-ATPase subunit interface; other site 1271864003992 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1271864003993 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1271864003994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864003995 dimer interface [polypeptide binding]; other site 1271864003996 conserved gate region; other site 1271864003997 putative PBP binding loops; other site 1271864003998 ABC-ATPase subunit interface; other site 1271864003999 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1271864004000 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1271864004001 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864004002 FeS/SAM binding site; other site 1271864004003 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1271864004004 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1271864004005 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1271864004006 Ligand binding site [chemical binding]; other site 1271864004007 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1271864004008 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1271864004009 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1271864004010 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1271864004011 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1271864004012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1271864004013 active site 1271864004014 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1271864004015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864004016 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1271864004017 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1271864004018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864004019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864004020 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1271864004021 putative dimerization interface [polypeptide binding]; other site 1271864004022 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1271864004023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1271864004024 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1271864004025 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1271864004026 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1271864004027 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1271864004028 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1271864004029 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1271864004030 putative C-terminal domain interface [polypeptide binding]; other site 1271864004031 putative GSH binding site (G-site) [chemical binding]; other site 1271864004032 putative dimer interface [polypeptide binding]; other site 1271864004033 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1271864004034 putative N-terminal domain interface [polypeptide binding]; other site 1271864004035 putative dimer interface [polypeptide binding]; other site 1271864004036 putative substrate binding pocket (H-site) [chemical binding]; other site 1271864004037 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1271864004038 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1271864004039 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1271864004040 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1271864004041 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1271864004042 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864004043 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1271864004044 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1271864004045 active site 1271864004046 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1271864004047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864004048 putative substrate translocation pore; other site 1271864004049 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1271864004050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864004051 active site 1271864004052 motif I; other site 1271864004053 motif II; other site 1271864004054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864004055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864004056 putative substrate translocation pore; other site 1271864004057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864004058 putative transporter; Provisional; Region: PRK04972 1271864004059 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1271864004060 TrkA-C domain; Region: TrkA_C; pfam02080 1271864004061 TrkA-C domain; Region: TrkA_C; pfam02080 1271864004062 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1271864004063 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1271864004064 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1271864004065 GSH binding site [chemical binding]; other site 1271864004066 catalytic residues [active] 1271864004067 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1271864004068 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1271864004069 dimer interface [polypeptide binding]; other site 1271864004070 FMN binding site [chemical binding]; other site 1271864004071 NADPH bind site [chemical binding]; other site 1271864004072 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1271864004073 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1271864004074 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1271864004075 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1271864004076 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1271864004077 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1271864004078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864004079 Walker A/P-loop; other site 1271864004080 ATP binding site [chemical binding]; other site 1271864004081 Q-loop/lid; other site 1271864004082 ABC transporter signature motif; other site 1271864004083 Walker B; other site 1271864004084 D-loop; other site 1271864004085 H-loop/switch region; other site 1271864004086 TOBE domain; Region: TOBE_2; pfam08402 1271864004087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864004088 dimer interface [polypeptide binding]; other site 1271864004089 conserved gate region; other site 1271864004090 putative PBP binding loops; other site 1271864004091 ABC-ATPase subunit interface; other site 1271864004092 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1271864004093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864004094 dimer interface [polypeptide binding]; other site 1271864004095 conserved gate region; other site 1271864004096 putative PBP binding loops; other site 1271864004097 ABC-ATPase subunit interface; other site 1271864004098 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1271864004099 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1271864004100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864004101 S-adenosylmethionine binding site [chemical binding]; other site 1271864004102 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1271864004103 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1271864004104 active site 1271864004105 P-loop; other site 1271864004106 phosphorylation site [posttranslational modification] 1271864004107 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1271864004108 Sulfatase; Region: Sulfatase; cl17466 1271864004109 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1271864004110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864004111 substrate binding pocket [chemical binding]; other site 1271864004112 membrane-bound complex binding site; other site 1271864004113 hinge residues; other site 1271864004114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864004115 dimer interface [polypeptide binding]; other site 1271864004116 conserved gate region; other site 1271864004117 putative PBP binding loops; other site 1271864004118 ABC-ATPase subunit interface; other site 1271864004119 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864004120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864004121 dimer interface [polypeptide binding]; other site 1271864004122 conserved gate region; other site 1271864004123 putative PBP binding loops; other site 1271864004124 ABC-ATPase subunit interface; other site 1271864004125 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1271864004126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864004127 substrate binding pocket [chemical binding]; other site 1271864004128 membrane-bound complex binding site; other site 1271864004129 hinge residues; other site 1271864004130 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1271864004131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864004132 Walker A/P-loop; other site 1271864004133 ATP binding site [chemical binding]; other site 1271864004134 Q-loop/lid; other site 1271864004135 ABC transporter signature motif; other site 1271864004136 Walker B; other site 1271864004137 D-loop; other site 1271864004138 H-loop/switch region; other site 1271864004139 putative lipoprotein; Provisional; Region: PRK10533 1271864004140 hypothetical protein; Provisional; Region: PRK02877 1271864004141 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1271864004142 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1271864004143 amidase catalytic site [active] 1271864004144 Zn binding residues [ion binding]; other site 1271864004145 substrate binding site [chemical binding]; other site 1271864004146 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1271864004147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1271864004148 NAD(P) binding site [chemical binding]; other site 1271864004149 active site 1271864004150 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1271864004151 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1271864004152 putative NAD(P) binding site [chemical binding]; other site 1271864004153 putative active site [active] 1271864004154 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1271864004155 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1271864004156 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1271864004157 tetramer interface [polypeptide binding]; other site 1271864004158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864004159 catalytic residue [active] 1271864004160 pyruvate dehydrogenase; Provisional; Region: PRK09124 1271864004161 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1271864004162 PYR/PP interface [polypeptide binding]; other site 1271864004163 dimer interface [polypeptide binding]; other site 1271864004164 tetramer interface [polypeptide binding]; other site 1271864004165 TPP binding site [chemical binding]; other site 1271864004166 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1271864004167 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1271864004168 TPP-binding site [chemical binding]; other site 1271864004169 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1271864004170 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1271864004171 FAD binding pocket [chemical binding]; other site 1271864004172 FAD binding motif [chemical binding]; other site 1271864004173 phosphate binding motif [ion binding]; other site 1271864004174 beta-alpha-beta structure motif; other site 1271864004175 NAD binding pocket [chemical binding]; other site 1271864004176 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1271864004177 catalytic loop [active] 1271864004178 iron binding site [ion binding]; other site 1271864004179 hybrid cluster protein; Provisional; Region: PRK05290 1271864004180 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1271864004181 ACS interaction site; other site 1271864004182 CODH interaction site; other site 1271864004183 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1271864004184 hybrid metal cluster; other site 1271864004185 Predicted membrane protein [Function unknown]; Region: COG2431 1271864004186 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1271864004187 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1271864004188 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1271864004189 putative active site [active] 1271864004190 putative metal-binding site [ion binding]; other site 1271864004191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1271864004192 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1271864004193 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864004194 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864004195 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1271864004196 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1271864004197 Walker A/P-loop; other site 1271864004198 ATP binding site [chemical binding]; other site 1271864004199 Q-loop/lid; other site 1271864004200 ABC transporter signature motif; other site 1271864004201 Walker B; other site 1271864004202 D-loop; other site 1271864004203 H-loop/switch region; other site 1271864004204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1271864004205 FtsX-like permease family; Region: FtsX; pfam02687 1271864004206 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1271864004207 DNA-binding site [nucleotide binding]; DNA binding site 1271864004208 RNA-binding motif; other site 1271864004209 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1271864004210 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1271864004211 Clp amino terminal domain; Region: Clp_N; pfam02861 1271864004212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864004213 Walker A motif; other site 1271864004214 ATP binding site [chemical binding]; other site 1271864004215 Walker B motif; other site 1271864004216 arginine finger; other site 1271864004217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864004218 Walker A motif; other site 1271864004219 ATP binding site [chemical binding]; other site 1271864004220 Walker B motif; other site 1271864004221 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1271864004222 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1271864004223 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1271864004224 DNA binding site [nucleotide binding] 1271864004225 active site 1271864004226 Int/Topo IB signature motif; other site 1271864004227 Isochorismatase family; Region: Isochorismatase; pfam00857 1271864004228 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1271864004229 catalytic triad [active] 1271864004230 dimer interface [polypeptide binding]; other site 1271864004231 conserved cis-peptide bond; other site 1271864004232 Pirin-related protein [General function prediction only]; Region: COG1741 1271864004233 Pirin; Region: Pirin; pfam02678 1271864004234 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1271864004235 LysR family transcriptional regulator; Provisional; Region: PRK14997 1271864004236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864004237 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1271864004238 putative effector binding pocket; other site 1271864004239 putative dimerization interface [polypeptide binding]; other site 1271864004240 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1271864004241 rRNA binding site [nucleotide binding]; other site 1271864004242 predicted 30S ribosome binding site; other site 1271864004243 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1271864004244 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1271864004245 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864004246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864004247 Walker A/P-loop; other site 1271864004248 ATP binding site [chemical binding]; other site 1271864004249 Q-loop/lid; other site 1271864004250 ABC transporter signature motif; other site 1271864004251 Walker B; other site 1271864004252 D-loop; other site 1271864004253 H-loop/switch region; other site 1271864004254 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1271864004255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864004256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864004257 Walker A/P-loop; other site 1271864004258 ATP binding site [chemical binding]; other site 1271864004259 Q-loop/lid; other site 1271864004260 ABC transporter signature motif; other site 1271864004261 Walker B; other site 1271864004262 D-loop; other site 1271864004263 H-loop/switch region; other site 1271864004264 thioredoxin reductase; Provisional; Region: PRK10262 1271864004265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864004266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864004267 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1271864004268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864004269 putative DNA binding site [nucleotide binding]; other site 1271864004270 putative Zn2+ binding site [ion binding]; other site 1271864004271 AsnC family; Region: AsnC_trans_reg; pfam01037 1271864004272 DNA translocase FtsK; Provisional; Region: PRK10263 1271864004273 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1271864004274 DNA translocase FtsK; Provisional; Region: PRK10263 1271864004275 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1271864004276 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1271864004277 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1271864004278 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1271864004279 recombination factor protein RarA; Reviewed; Region: PRK13342 1271864004280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864004281 Walker A motif; other site 1271864004282 ATP binding site [chemical binding]; other site 1271864004283 Walker B motif; other site 1271864004284 arginine finger; other site 1271864004285 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1271864004286 seryl-tRNA synthetase; Provisional; Region: PRK05431 1271864004287 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1271864004288 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1271864004289 dimer interface [polypeptide binding]; other site 1271864004290 active site 1271864004291 motif 1; other site 1271864004292 motif 2; other site 1271864004293 motif 3; other site 1271864004294 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1271864004295 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1271864004296 putative [Fe4-S4] binding site [ion binding]; other site 1271864004297 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864004298 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1271864004299 putative molybdopterin cofactor binding site; other site 1271864004300 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1271864004301 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864004302 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1271864004303 putative MFS family transporter protein; Provisional; Region: PRK03633 1271864004304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864004305 putative substrate translocation pore; other site 1271864004306 inner membrane transporter YjeM; Provisional; Region: PRK15238 1271864004307 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1271864004308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864004309 FeS/SAM binding site; other site 1271864004310 integrase; Provisional; Region: int; PHA02601 1271864004311 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 1271864004312 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1271864004313 formate transporter; Provisional; Region: PRK10805 1271864004314 uncharacterized domain; Region: TIGR00702 1271864004315 YcaO-like family; Region: YcaO; pfam02624 1271864004316 Predicted membrane protein [Function unknown]; Region: COG2323 1271864004317 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1271864004318 homodimer interface [polypeptide binding]; other site 1271864004319 substrate-cofactor binding pocket; other site 1271864004320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864004321 catalytic residue [active] 1271864004322 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1271864004323 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1271864004324 hinge; other site 1271864004325 active site 1271864004326 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1271864004327 cytidylate kinase; Provisional; Region: cmk; PRK00023 1271864004328 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1271864004329 CMP-binding site; other site 1271864004330 The sites determining sugar specificity; other site 1271864004331 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1271864004332 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1271864004333 RNA binding site [nucleotide binding]; other site 1271864004334 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1271864004335 RNA binding site [nucleotide binding]; other site 1271864004336 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1271864004337 RNA binding site [nucleotide binding]; other site 1271864004338 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1271864004339 RNA binding site [nucleotide binding]; other site 1271864004340 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1271864004341 RNA binding site [nucleotide binding]; other site 1271864004342 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1271864004343 IHF dimer interface [polypeptide binding]; other site 1271864004344 IHF - DNA interface [nucleotide binding]; other site 1271864004345 ComEC family competence protein; Provisional; Region: PRK11539 1271864004346 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1271864004347 Competence protein; Region: Competence; pfam03772 1271864004348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1271864004349 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1271864004350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864004351 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1271864004352 Walker A/P-loop; other site 1271864004353 ATP binding site [chemical binding]; other site 1271864004354 Q-loop/lid; other site 1271864004355 ABC transporter signature motif; other site 1271864004356 Walker B; other site 1271864004357 D-loop; other site 1271864004358 H-loop/switch region; other site 1271864004359 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1271864004360 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1271864004361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1271864004362 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1271864004363 hypothetical protein; Provisional; Region: PRK11827 1271864004364 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1271864004365 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1271864004366 Ligand binding site; other site 1271864004367 oligomer interface; other site 1271864004368 hypothetical protein; Provisional; Region: PRK10593 1271864004369 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1271864004370 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1271864004371 putative active site [active] 1271864004372 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1271864004373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864004374 S-adenosylmethionine binding site [chemical binding]; other site 1271864004375 condesin subunit F; Provisional; Region: PRK05260 1271864004376 condesin subunit E; Provisional; Region: PRK05256 1271864004377 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1271864004378 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1271864004379 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1271864004380 murein L,D-transpeptidase; Provisional; Region: PRK10594 1271864004381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1271864004382 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1271864004383 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1271864004384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1271864004385 Peptidase M15; Region: Peptidase_M15_3; cl01194 1271864004386 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1271864004387 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1271864004388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864004389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864004390 homodimer interface [polypeptide binding]; other site 1271864004391 catalytic residue [active] 1271864004392 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864004393 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1271864004394 trimer interface [polypeptide binding]; other site 1271864004395 eyelet of channel; other site 1271864004396 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1271864004397 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1271864004398 putative dimer interface [polypeptide binding]; other site 1271864004399 putative anticodon binding site; other site 1271864004400 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1271864004401 homodimer interface [polypeptide binding]; other site 1271864004402 motif 1; other site 1271864004403 motif 2; other site 1271864004404 active site 1271864004405 motif 3; other site 1271864004406 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1271864004407 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864004408 putative DNA binding site [nucleotide binding]; other site 1271864004409 putative Zn2+ binding site [ion binding]; other site 1271864004410 AsnC family; Region: AsnC_trans_reg; pfam01037 1271864004411 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1271864004412 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1271864004413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864004414 catalytic residue [active] 1271864004415 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1271864004416 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1271864004417 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1271864004418 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1271864004419 active site 1271864004420 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1271864004421 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1271864004422 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1271864004423 Int/Topo IB signature motif; other site 1271864004424 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1271864004425 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1271864004426 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1271864004427 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1271864004428 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1271864004429 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1271864004430 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 1271864004431 Tetrahydromethanopterin S-methyltransferase, subunit G; Region: MtrG; cl01679 1271864004432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864004433 transcriptional repressor DicA; Reviewed; Region: PRK09706 1271864004434 non-specific DNA binding site [nucleotide binding]; other site 1271864004435 salt bridge; other site 1271864004436 sequence-specific DNA binding site [nucleotide binding]; other site 1271864004437 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1271864004438 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1271864004439 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1271864004440 Replication protein P; Region: Phage_lambda_P; pfam06992 1271864004441 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1271864004442 DinI-like family; Region: DinI; pfam06183 1271864004443 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1271864004444 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1271864004445 Antitermination protein; Region: Antiterm; pfam03589 1271864004446 Antitermination protein; Region: Antiterm; pfam03589 1271864004447 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1271864004448 catalytic residues [active] 1271864004449 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1271864004450 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1271864004451 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1271864004452 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 1271864004453 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1271864004454 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1271864004455 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1271864004456 Clp protease; Region: CLP_protease; pfam00574 1271864004457 oligomer interface [polypeptide binding]; other site 1271864004458 active site residues [active] 1271864004459 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1271864004460 Uncharacterized conserved protein [Function unknown]; Region: COG5471 1271864004461 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 1271864004462 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1271864004463 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1271864004464 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1271864004465 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 1271864004466 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 1271864004467 Phage-related minor tail protein [Function unknown]; Region: COG5281 1271864004468 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1271864004469 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1271864004470 Phage-related protein [Function unknown]; Region: COG4718 1271864004471 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1271864004472 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1271864004473 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1271864004474 E-class dimer interface [polypeptide binding]; other site 1271864004475 P-class dimer interface [polypeptide binding]; other site 1271864004476 active site 1271864004477 Cu2+ binding site [ion binding]; other site 1271864004478 Zn2+ binding site [ion binding]; other site 1271864004479 Phage-related protein [Function unknown]; Region: gp18; COG4672 1271864004480 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1271864004481 MPN+ (JAMM) motif; other site 1271864004482 Zinc-binding site [ion binding]; other site 1271864004483 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1271864004484 NlpC/P60 family; Region: NLPC_P60; cl17555 1271864004485 Phage-related protein, tail component [Function unknown]; Region: COG4723 1271864004486 Phage-related protein, tail component [Function unknown]; Region: COG4733 1271864004487 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1271864004488 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1271864004489 Interdomain contacts; other site 1271864004490 Cytokine receptor motif; other site 1271864004491 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1271864004492 Fibronectin type III protein; Region: DUF3672; pfam12421 1271864004493 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1271864004494 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1271864004495 Phage Tail Collar Domain; Region: Collar; pfam07484 1271864004496 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1271864004497 ADP-ribose binding site [chemical binding]; other site 1271864004498 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1271864004499 type III secretion protein SopE; Provisional; Region: PRK15279 1271864004500 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 1271864004501 SopE GEF domain; Region: SopE_GEF; pfam07487 1271864004502 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1271864004503 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1271864004504 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1271864004505 DNA-binding interface [nucleotide binding]; DNA binding site 1271864004506 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1271864004507 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1271864004508 aminopeptidase N; Provisional; Region: pepN; PRK14015 1271864004509 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1271864004510 active site 1271864004511 Zn binding site [ion binding]; other site 1271864004512 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1271864004513 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1271864004514 quinone interaction residues [chemical binding]; other site 1271864004515 active site 1271864004516 catalytic residues [active] 1271864004517 FMN binding site [chemical binding]; other site 1271864004518 substrate binding site [chemical binding]; other site 1271864004519 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1271864004520 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1271864004521 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1271864004522 MOSC domain; Region: MOSC; pfam03473 1271864004523 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1271864004524 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1271864004525 catalytic loop [active] 1271864004526 iron binding site [ion binding]; other site 1271864004527 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1271864004528 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1271864004529 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1271864004530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864004531 S-adenosylmethionine binding site [chemical binding]; other site 1271864004532 ABC transporter ATPase component; Reviewed; Region: PRK11147 1271864004533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864004534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864004535 Walker A/P-loop; other site 1271864004536 Walker A/P-loop; other site 1271864004537 ATP binding site [chemical binding]; other site 1271864004538 ATP binding site [chemical binding]; other site 1271864004539 Q-loop/lid; other site 1271864004540 Q-loop/lid; other site 1271864004541 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864004542 ABC transporter signature motif; other site 1271864004543 Walker B; other site 1271864004544 D-loop; other site 1271864004545 ABC transporter; Region: ABC_tran_2; pfam12848 1271864004546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864004547 paraquat-inducible protein B; Provisional; Region: PRK10807 1271864004548 mce related protein; Region: MCE; pfam02470 1271864004549 mce related protein; Region: MCE; pfam02470 1271864004550 mce related protein; Region: MCE; pfam02470 1271864004551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1271864004552 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1271864004553 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1271864004554 active site 1 [active] 1271864004555 dimer interface [polypeptide binding]; other site 1271864004556 active site 2 [active] 1271864004557 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1271864004558 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1271864004559 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1271864004560 outer membrane protein A; Reviewed; Region: PRK10808 1271864004561 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1271864004562 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1271864004563 ligand binding site [chemical binding]; other site 1271864004564 cell division inhibitor SulA; Region: sula; TIGR00623 1271864004565 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1271864004566 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1271864004567 TIGR01666 family membrane protein; Region: YCCS 1271864004568 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1271864004569 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1271864004570 Predicted membrane protein [Function unknown]; Region: COG3304 1271864004571 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1271864004572 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1271864004573 DNA helicase IV; Provisional; Region: helD; PRK11054 1271864004574 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1271864004575 Part of AAA domain; Region: AAA_19; pfam13245 1271864004576 Family description; Region: UvrD_C_2; pfam13538 1271864004577 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1271864004578 active site 1271864004579 dimer interfaces [polypeptide binding]; other site 1271864004580 catalytic residues [active] 1271864004581 hypothetical protein; Provisional; Region: PRK03641 1271864004582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1271864004583 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1271864004584 heat shock protein HspQ; Provisional; Region: PRK14129 1271864004585 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1271864004586 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1271864004587 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1271864004588 putative RNA binding site [nucleotide binding]; other site 1271864004589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864004590 S-adenosylmethionine binding site [chemical binding]; other site 1271864004591 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1271864004592 substrate binding site [chemical binding]; other site 1271864004593 Cupin domain; Region: Cupin_2; cl17218 1271864004594 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864004595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864004596 acylphosphatase; Provisional; Region: PRK14426 1271864004597 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1271864004598 sulfur transfer protein TusE; Provisional; Region: PRK11508 1271864004599 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1271864004600 YccA-like proteins; Region: YccA_like; cd10433 1271864004601 PipA protein; Region: PipA; pfam07108 1271864004602 secreted effector protein PipB; Provisional; Region: PRK15197 1271864004603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864004604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864004605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864004606 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 1271864004607 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 1271864004608 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 1271864004609 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1271864004610 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1271864004611 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1271864004612 HAMP domain; Region: HAMP; pfam00672 1271864004613 dimerization interface [polypeptide binding]; other site 1271864004614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864004615 dimer interface [polypeptide binding]; other site 1271864004616 phosphorylation site [posttranslational modification] 1271864004617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864004618 ATP binding site [chemical binding]; other site 1271864004619 Mg2+ binding site [ion binding]; other site 1271864004620 G-X-G motif; other site 1271864004621 Response regulator receiver domain; Region: Response_reg; pfam00072 1271864004622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864004623 active site 1271864004624 phosphorylation site [posttranslational modification] 1271864004625 intermolecular recognition site; other site 1271864004626 dimerization interface [polypeptide binding]; other site 1271864004627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1271864004628 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1271864004629 active site 1271864004630 homotetramer interface [polypeptide binding]; other site 1271864004631 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 1271864004632 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1271864004633 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1271864004634 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1271864004635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1271864004636 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1271864004637 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1271864004638 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1271864004639 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1271864004640 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1271864004641 NAD binding site [chemical binding]; other site 1271864004642 catalytic residues [active] 1271864004643 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1271864004644 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1271864004645 putative active site [active] 1271864004646 putative metal binding site [ion binding]; other site 1271864004647 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1271864004648 putative substrate binding pocket [chemical binding]; other site 1271864004649 trimer interface [polypeptide binding]; other site 1271864004650 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1271864004651 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1271864004652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864004653 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1271864004654 putative substrate translocation pore; other site 1271864004655 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1271864004656 Cupin domain; Region: Cupin_2; pfam07883 1271864004657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864004658 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1271864004659 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1271864004660 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1271864004661 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1271864004662 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1271864004663 HSP70 interaction site [polypeptide binding]; other site 1271864004664 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1271864004665 substrate binding site [polypeptide binding]; other site 1271864004666 dimer interface [polypeptide binding]; other site 1271864004667 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1271864004668 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1271864004669 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1271864004670 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1271864004671 DsbD alpha interface [polypeptide binding]; other site 1271864004672 catalytic residues [active] 1271864004673 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1271864004674 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1271864004675 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1271864004676 catalytic residues [active] 1271864004677 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1271864004678 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1271864004679 catalytic residues [active] 1271864004680 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1271864004681 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1271864004682 catalytic core [active] 1271864004683 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1271864004684 hypothetical protein; Provisional; Region: PRK10174 1271864004685 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1271864004686 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1271864004687 General stress protein [General function prediction only]; Region: GsiB; COG3729 1271864004688 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1271864004689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864004690 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1271864004691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1271864004692 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1271864004693 Predicted transcriptional regulator [Transcription]; Region: COG3905 1271864004694 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1271864004695 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1271864004696 Glutamate binding site [chemical binding]; other site 1271864004697 NAD binding site [chemical binding]; other site 1271864004698 catalytic residues [active] 1271864004699 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1271864004700 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1271864004701 Na binding site [ion binding]; other site 1271864004702 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1271864004703 hypothetical protein; Provisional; Region: PRK10536 1271864004704 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1271864004705 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1271864004706 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1271864004707 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1271864004708 putative active site [active] 1271864004709 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1271864004710 Na binding site [ion binding]; other site 1271864004711 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1271864004712 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1271864004713 putative active site cavity [active] 1271864004714 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1271864004715 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1271864004716 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1271864004717 putative sialic acid transporter; Provisional; Region: PRK12307 1271864004718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864004719 putative substrate translocation pore; other site 1271864004720 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1271864004721 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1271864004722 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1271864004723 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1271864004724 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1271864004725 putative ligand binding site [chemical binding]; other site 1271864004726 NAD binding site [chemical binding]; other site 1271864004727 dimerization interface [polypeptide binding]; other site 1271864004728 catalytic site [active] 1271864004729 putative hydrolase; Validated; Region: PRK09248 1271864004730 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1271864004731 active site 1271864004732 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1271864004733 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1271864004734 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1271864004735 curli assembly protein CsgF; Provisional; Region: PRK10050 1271864004736 curli assembly protein CsgE; Provisional; Region: PRK10386 1271864004737 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1271864004738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864004739 DNA binding residues [nucleotide binding] 1271864004740 dimerization interface [polypeptide binding]; other site 1271864004741 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1271864004742 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1271864004743 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1271864004744 major curlin subunit; Provisional; Region: csgA; PRK10051 1271864004745 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1271864004746 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1271864004747 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1271864004748 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1271864004749 putative ADP-ribose binding site [chemical binding]; other site 1271864004750 putative active site [active] 1271864004751 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1271864004752 PLD-like domain; Region: PLDc_2; pfam13091 1271864004753 putative active site [active] 1271864004754 catalytic site [active] 1271864004755 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1271864004756 PLD-like domain; Region: PLDc_2; pfam13091 1271864004757 putative active site [active] 1271864004758 catalytic site [active] 1271864004759 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1271864004760 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1271864004761 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1271864004762 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1271864004763 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1271864004764 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1271864004765 Ligand binding site; other site 1271864004766 DXD motif; other site 1271864004767 lipoprotein; Provisional; Region: PRK10175 1271864004768 secY/secA suppressor protein; Provisional; Region: PRK11467 1271864004769 drug efflux system protein MdtG; Provisional; Region: PRK09874 1271864004770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864004771 putative substrate translocation pore; other site 1271864004772 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1271864004773 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1271864004774 putative acyl-acceptor binding pocket; other site 1271864004775 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1271864004776 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1271864004777 active site residue [active] 1271864004778 hypothetical protein; Provisional; Region: PRK03757 1271864004779 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1271864004780 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1271864004781 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1271864004782 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1271864004783 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1271864004784 DNA damage-inducible protein I; Provisional; Region: PRK10597 1271864004785 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1271864004786 active site 1271864004787 substrate binding pocket [chemical binding]; other site 1271864004788 dimer interface [polypeptide binding]; other site 1271864004789 lipoprotein; Provisional; Region: PRK10598 1271864004790 glutaredoxin 2; Provisional; Region: PRK10387 1271864004791 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1271864004792 C-terminal domain interface [polypeptide binding]; other site 1271864004793 GSH binding site (G-site) [chemical binding]; other site 1271864004794 catalytic residues [active] 1271864004795 putative dimer interface [polypeptide binding]; other site 1271864004796 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1271864004797 N-terminal domain interface [polypeptide binding]; other site 1271864004798 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1271864004799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864004800 putative substrate translocation pore; other site 1271864004801 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1271864004802 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1271864004803 hypothetical protein; Provisional; Region: PRK11239 1271864004804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1271864004805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1271864004806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1271864004807 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1271864004808 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1271864004809 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1271864004810 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1271864004811 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1271864004812 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1271864004813 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1271864004814 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1271864004815 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1271864004816 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1271864004817 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1271864004818 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1271864004819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1271864004820 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1271864004821 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1271864004822 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1271864004823 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1271864004824 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1271864004825 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1271864004826 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1271864004827 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1271864004828 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1271864004829 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1271864004830 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1271864004831 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1271864004832 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1271864004833 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1271864004834 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1271864004835 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1271864004836 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1271864004837 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1271864004838 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1271864004839 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1271864004840 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1271864004841 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1271864004842 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1271864004843 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1271864004844 ribonuclease E; Reviewed; Region: rne; PRK10811 1271864004845 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1271864004846 homodimer interface [polypeptide binding]; other site 1271864004847 oligonucleotide binding site [chemical binding]; other site 1271864004848 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1271864004849 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1271864004850 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864004851 RNA binding surface [nucleotide binding]; other site 1271864004852 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1271864004853 active site 1271864004854 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1271864004855 Maf-like protein; Region: Maf; pfam02545 1271864004856 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1271864004857 active site 1271864004858 dimer interface [polypeptide binding]; other site 1271864004859 hypothetical protein; Provisional; Region: PRK11193 1271864004860 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1271864004861 putative phosphate acyltransferase; Provisional; Region: PRK05331 1271864004862 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1271864004863 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1271864004864 dimer interface [polypeptide binding]; other site 1271864004865 active site 1271864004866 CoA binding pocket [chemical binding]; other site 1271864004867 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1271864004868 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1271864004869 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1271864004870 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1271864004871 NAD(P) binding site [chemical binding]; other site 1271864004872 homotetramer interface [polypeptide binding]; other site 1271864004873 homodimer interface [polypeptide binding]; other site 1271864004874 active site 1271864004875 acyl carrier protein; Provisional; Region: acpP; PRK00982 1271864004876 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1271864004877 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1271864004878 dimer interface [polypeptide binding]; other site 1271864004879 active site 1271864004880 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1271864004881 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1271864004882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864004883 catalytic residue [active] 1271864004884 conserved hypothetical protein, YceG family; Region: TIGR00247 1271864004885 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1271864004886 dimerization interface [polypeptide binding]; other site 1271864004887 thymidylate kinase; Validated; Region: tmk; PRK00698 1271864004888 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1271864004889 TMP-binding site; other site 1271864004890 ATP-binding site [chemical binding]; other site 1271864004891 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1271864004892 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1271864004893 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1271864004894 active site 1271864004895 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1271864004896 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1271864004897 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1271864004898 active site turn [active] 1271864004899 phosphorylation site [posttranslational modification] 1271864004900 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1271864004901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864004902 N-terminal plug; other site 1271864004903 ligand-binding site [chemical binding]; other site 1271864004904 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1271864004905 nucleotide binding site/active site [active] 1271864004906 HIT family signature motif; other site 1271864004907 catalytic residue [active] 1271864004908 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1271864004909 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1271864004910 putative dimer interface [polypeptide binding]; other site 1271864004911 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1271864004912 thiamine kinase; Region: ycfN_thiK; TIGR02721 1271864004913 thiamine kinase; Provisional; Region: thiK; PRK10271 1271864004914 substrate binding site [chemical binding]; other site 1271864004915 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1271864004916 beta-hexosaminidase; Provisional; Region: PRK05337 1271864004917 hypothetical protein; Provisional; Region: PRK04940 1271864004918 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1271864004919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864004920 hypothetical protein; Provisional; Region: PRK11280 1271864004921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1271864004922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864004923 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864004924 L,D-transpeptidase; Provisional; Region: PRK10190 1271864004925 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864004926 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1271864004927 transcription-repair coupling factor; Provisional; Region: PRK10689 1271864004928 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1271864004929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864004930 ATP binding site [chemical binding]; other site 1271864004931 putative Mg++ binding site [ion binding]; other site 1271864004932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864004933 nucleotide binding region [chemical binding]; other site 1271864004934 ATP-binding site [chemical binding]; other site 1271864004935 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1271864004936 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1271864004937 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1271864004938 FtsX-like permease family; Region: FtsX; pfam02687 1271864004939 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1271864004940 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1271864004941 Walker A/P-loop; other site 1271864004942 ATP binding site [chemical binding]; other site 1271864004943 Q-loop/lid; other site 1271864004944 ABC transporter signature motif; other site 1271864004945 Walker B; other site 1271864004946 D-loop; other site 1271864004947 H-loop/switch region; other site 1271864004948 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1271864004949 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1271864004950 FtsX-like permease family; Region: FtsX; pfam02687 1271864004951 fructokinase; Reviewed; Region: PRK09557 1271864004952 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864004953 nucleotide binding site [chemical binding]; other site 1271864004954 NAD-dependent deacetylase; Provisional; Region: PRK00481 1271864004955 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1271864004956 NAD+ binding site [chemical binding]; other site 1271864004957 substrate binding site [chemical binding]; other site 1271864004958 Zn binding site [ion binding]; other site 1271864004959 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1271864004960 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1271864004961 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1271864004962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864004963 dimer interface [polypeptide binding]; other site 1271864004964 conserved gate region; other site 1271864004965 putative PBP binding loops; other site 1271864004966 ABC-ATPase subunit interface; other site 1271864004967 Sif protein; Region: Sif; pfam06767 1271864004968 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1271864004969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864004970 dimer interface [polypeptide binding]; other site 1271864004971 conserved gate region; other site 1271864004972 putative PBP binding loops; other site 1271864004973 ABC-ATPase subunit interface; other site 1271864004974 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1271864004975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864004976 Walker A/P-loop; other site 1271864004977 ATP binding site [chemical binding]; other site 1271864004978 Q-loop/lid; other site 1271864004979 ABC transporter signature motif; other site 1271864004980 Walker B; other site 1271864004981 D-loop; other site 1271864004982 H-loop/switch region; other site 1271864004983 TOBE domain; Region: TOBE_2; pfam08402 1271864004984 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1271864004985 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1271864004986 metal binding site [ion binding]; metal-binding site 1271864004987 dimer interface [polypeptide binding]; other site 1271864004988 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1271864004989 Cupin-like domain; Region: Cupin_8; pfam13621 1271864004990 sensor protein PhoQ; Provisional; Region: PRK10815 1271864004991 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1271864004992 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1271864004993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864004994 ATP binding site [chemical binding]; other site 1271864004995 Mg2+ binding site [ion binding]; other site 1271864004996 G-X-G motif; other site 1271864004997 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1271864004998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864004999 active site 1271864005000 phosphorylation site [posttranslational modification] 1271864005001 intermolecular recognition site; other site 1271864005002 dimerization interface [polypeptide binding]; other site 1271864005003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864005004 DNA binding site [nucleotide binding] 1271864005005 adenylosuccinate lyase; Provisional; Region: PRK09285 1271864005006 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1271864005007 tetramer interface [polypeptide binding]; other site 1271864005008 active site 1271864005009 putative lysogenization regulator; Reviewed; Region: PRK00218 1271864005010 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1271864005011 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1271864005012 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1271864005013 nudix motif; other site 1271864005014 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1271864005015 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1271864005016 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1271864005017 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1271864005018 probable active site [active] 1271864005019 isocitrate dehydrogenase; Validated; Region: PRK07362 1271864005020 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1271864005021 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1271864005022 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1271864005023 DinI-like family; Region: DinI; pfam06183 1271864005024 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1271864005025 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1271864005026 putative sugar binding sites [chemical binding]; other site 1271864005027 Q-X-W motif; other site 1271864005028 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1271864005029 DNA-binding site [nucleotide binding]; DNA binding site 1271864005030 RNA-binding motif; other site 1271864005031 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1271864005032 lysozyme inhibitor; Provisional; Region: PRK13791 1271864005033 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1271864005034 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1271864005035 putative dimer interface [polypeptide binding]; other site 1271864005036 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1271864005037 BNR repeat-like domain; Region: BNR_2; pfam13088 1271864005038 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1271864005039 TRL-like protein family; Region: TRL; pfam13146 1271864005040 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1271864005041 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1271864005042 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1271864005043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864005044 dimer interface [polypeptide binding]; other site 1271864005045 conserved gate region; other site 1271864005046 ABC-ATPase subunit interface; other site 1271864005047 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1271864005048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864005049 dimer interface [polypeptide binding]; other site 1271864005050 conserved gate region; other site 1271864005051 putative PBP binding loops; other site 1271864005052 ABC-ATPase subunit interface; other site 1271864005053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864005054 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1271864005055 Walker A/P-loop; other site 1271864005056 ATP binding site [chemical binding]; other site 1271864005057 Q-loop/lid; other site 1271864005058 ABC transporter signature motif; other site 1271864005059 Walker B; other site 1271864005060 D-loop; other site 1271864005061 H-loop/switch region; other site 1271864005062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864005063 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1271864005064 Walker A/P-loop; other site 1271864005065 ATP binding site [chemical binding]; other site 1271864005066 Q-loop/lid; other site 1271864005067 ABC transporter signature motif; other site 1271864005068 Walker B; other site 1271864005069 D-loop; other site 1271864005070 H-loop/switch region; other site 1271864005071 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1271864005072 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864005073 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1271864005074 dimerization interface [polypeptide binding]; other site 1271864005075 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1271864005076 aminoglycoside resistance protein; Provisional; Region: PRK13746 1271864005077 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1271864005078 active site 1271864005079 NTP binding site [chemical binding]; other site 1271864005080 metal binding triad [ion binding]; metal-binding site 1271864005081 antibiotic binding site [chemical binding]; other site 1271864005082 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1271864005083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864005084 DNA binding residues [nucleotide binding] 1271864005085 transcriptional regulator MirA; Provisional; Region: PRK15043 1271864005086 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1271864005087 DNA binding residues [nucleotide binding] 1271864005088 dimer interface [polypeptide binding]; other site 1271864005089 Pleckstrin homology-like domain; Region: PH-like; cl17171 1271864005090 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1271864005091 chorismate mutase; Provisional; Region: PRK08055 1271864005092 leucine export protein LeuE; Provisional; Region: PRK10958 1271864005093 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1271864005094 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1271864005095 hypothetical protein; Provisional; Region: PRK10457 1271864005096 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1271864005097 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1271864005098 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1271864005099 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1271864005100 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1271864005101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005102 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864005103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864005104 Predicted membrane protein [Function unknown]; Region: COG2707 1271864005105 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1271864005106 putative deacylase active site [active] 1271864005107 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1271864005108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864005109 metal binding site [ion binding]; metal-binding site 1271864005110 active site 1271864005111 I-site; other site 1271864005112 hypothetical protein; Provisional; Region: PRK05325 1271864005113 PrkA family serine protein kinase; Provisional; Region: PRK15455 1271864005114 AAA ATPase domain; Region: AAA_16; pfam13191 1271864005115 Walker A motif; other site 1271864005116 ATP binding site [chemical binding]; other site 1271864005117 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1271864005118 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1271864005119 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1271864005120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864005121 FeS/SAM binding site; other site 1271864005122 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1271864005123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864005124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864005125 active site 1271864005126 catalytic tetrad [active] 1271864005127 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1271864005128 active site 1271864005129 phosphate binding residues; other site 1271864005130 catalytic residues [active] 1271864005131 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1271864005132 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1271864005133 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1271864005134 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1271864005135 SelR domain; Region: SelR; pfam01641 1271864005136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1271864005137 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1271864005138 Isochorismatase family; Region: Isochorismatase; pfam00857 1271864005139 catalytic triad [active] 1271864005140 metal binding site [ion binding]; metal-binding site 1271864005141 conserved cis-peptide bond; other site 1271864005142 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1271864005143 active site 1271864005144 homodimer interface [polypeptide binding]; other site 1271864005145 protease 4; Provisional; Region: PRK10949 1271864005146 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1271864005147 tandem repeat interface [polypeptide binding]; other site 1271864005148 oligomer interface [polypeptide binding]; other site 1271864005149 active site residues [active] 1271864005150 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1271864005151 tandem repeat interface [polypeptide binding]; other site 1271864005152 oligomer interface [polypeptide binding]; other site 1271864005153 active site residues [active] 1271864005154 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1271864005155 putative FMN binding site [chemical binding]; other site 1271864005156 selenophosphate synthetase; Provisional; Region: PRK00943 1271864005157 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1271864005158 dimerization interface [polypeptide binding]; other site 1271864005159 putative ATP binding site [chemical binding]; other site 1271864005160 DNA topoisomerase III; Provisional; Region: PRK07726 1271864005161 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1271864005162 active site 1271864005163 putative interdomain interaction site [polypeptide binding]; other site 1271864005164 putative metal-binding site [ion binding]; other site 1271864005165 putative nucleotide binding site [chemical binding]; other site 1271864005166 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1271864005167 domain I; other site 1271864005168 DNA binding groove [nucleotide binding] 1271864005169 phosphate binding site [ion binding]; other site 1271864005170 domain II; other site 1271864005171 domain III; other site 1271864005172 nucleotide binding site [chemical binding]; other site 1271864005173 catalytic site [active] 1271864005174 domain IV; other site 1271864005175 glutamate dehydrogenase; Provisional; Region: PRK09414 1271864005176 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1271864005177 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1271864005178 NAD(P) binding site [chemical binding]; other site 1271864005179 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1271864005180 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1271864005181 active site 1271864005182 8-oxo-dGMP binding site [chemical binding]; other site 1271864005183 nudix motif; other site 1271864005184 metal binding site [ion binding]; metal-binding site 1271864005185 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1271864005186 putative catalytic site [active] 1271864005187 putative phosphate binding site [ion binding]; other site 1271864005188 active site 1271864005189 metal binding site A [ion binding]; metal-binding site 1271864005190 DNA binding site [nucleotide binding] 1271864005191 putative AP binding site [nucleotide binding]; other site 1271864005192 putative metal binding site B [ion binding]; other site 1271864005193 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1271864005194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1271864005195 inhibitor-cofactor binding pocket; inhibition site 1271864005196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864005197 catalytic residue [active] 1271864005198 arginine succinyltransferase; Provisional; Region: PRK10456 1271864005199 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1271864005200 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1271864005201 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1271864005202 NAD(P) binding site [chemical binding]; other site 1271864005203 catalytic residues [active] 1271864005204 succinylarginine dihydrolase; Provisional; Region: PRK13281 1271864005205 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1271864005206 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1271864005207 putative active site [active] 1271864005208 Zn binding site [ion binding]; other site 1271864005209 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1271864005210 dimer interface [polypeptide binding]; other site 1271864005211 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1271864005212 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1271864005213 GIY-YIG motif/motif A; other site 1271864005214 active site 1271864005215 catalytic site [active] 1271864005216 putative DNA binding site [nucleotide binding]; other site 1271864005217 metal binding site [ion binding]; metal-binding site 1271864005218 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1271864005219 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1271864005220 homodimer interface [polypeptide binding]; other site 1271864005221 NAD binding pocket [chemical binding]; other site 1271864005222 ATP binding pocket [chemical binding]; other site 1271864005223 Mg binding site [ion binding]; other site 1271864005224 active-site loop [active] 1271864005225 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1271864005226 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1271864005227 active site 1271864005228 P-loop; other site 1271864005229 phosphorylation site [posttranslational modification] 1271864005230 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1271864005231 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1271864005232 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1271864005233 methionine cluster; other site 1271864005234 active site 1271864005235 phosphorylation site [posttranslational modification] 1271864005236 metal binding site [ion binding]; metal-binding site 1271864005237 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1271864005238 Cupin domain; Region: Cupin_2; pfam07883 1271864005239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864005240 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1271864005241 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1271864005242 NAD binding site [chemical binding]; other site 1271864005243 sugar binding site [chemical binding]; other site 1271864005244 divalent metal binding site [ion binding]; other site 1271864005245 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1271864005246 dimer interface [polypeptide binding]; other site 1271864005247 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1271864005248 putative active site [active] 1271864005249 YdjC motif; other site 1271864005250 Mg binding site [ion binding]; other site 1271864005251 putative homodimer interface [polypeptide binding]; other site 1271864005252 hydroperoxidase II; Provisional; Region: katE; PRK11249 1271864005253 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1271864005254 tetramer interface [polypeptide binding]; other site 1271864005255 heme binding pocket [chemical binding]; other site 1271864005256 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1271864005257 domain interactions; other site 1271864005258 cell division modulator; Provisional; Region: PRK10113 1271864005259 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1271864005260 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1271864005261 inner membrane protein; Provisional; Region: PRK11648 1271864005262 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1271864005263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1271864005264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864005265 motif II; other site 1271864005266 YniB-like protein; Region: YniB; pfam14002 1271864005267 Phosphotransferase enzyme family; Region: APH; pfam01636 1271864005268 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1271864005269 active site 1271864005270 ATP binding site [chemical binding]; other site 1271864005271 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1271864005272 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1271864005273 6-phosphofructokinase 2; Provisional; Region: PRK10294 1271864005274 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1271864005275 putative substrate binding site [chemical binding]; other site 1271864005276 putative ATP binding site [chemical binding]; other site 1271864005277 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1271864005278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 1271864005279 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1271864005280 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1271864005281 active site 1271864005282 substrate binding site [chemical binding]; other site 1271864005283 Mg2+ binding site [ion binding]; other site 1271864005284 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1271864005285 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1271864005286 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1271864005287 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1271864005288 active site 1271864005289 dimer interface [polypeptide binding]; other site 1271864005290 motif 1; other site 1271864005291 motif 2; other site 1271864005292 motif 3; other site 1271864005293 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1271864005294 anticodon binding site; other site 1271864005295 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1271864005296 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1271864005297 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1271864005298 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1271864005299 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1271864005300 23S rRNA binding site [nucleotide binding]; other site 1271864005301 L21 binding site [polypeptide binding]; other site 1271864005302 L13 binding site [polypeptide binding]; other site 1271864005303 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1271864005304 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1271864005305 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1271864005306 dimer interface [polypeptide binding]; other site 1271864005307 motif 1; other site 1271864005308 active site 1271864005309 motif 2; other site 1271864005310 motif 3; other site 1271864005311 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1271864005312 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1271864005313 putative tRNA-binding site [nucleotide binding]; other site 1271864005314 B3/4 domain; Region: B3_4; pfam03483 1271864005315 tRNA synthetase B5 domain; Region: B5; smart00874 1271864005316 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1271864005317 dimer interface [polypeptide binding]; other site 1271864005318 motif 1; other site 1271864005319 motif 3; other site 1271864005320 motif 2; other site 1271864005321 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1271864005322 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1271864005323 IHF dimer interface [polypeptide binding]; other site 1271864005324 IHF - DNA interface [nucleotide binding]; other site 1271864005325 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1271864005326 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864005327 ABC-ATPase subunit interface; other site 1271864005328 dimer interface [polypeptide binding]; other site 1271864005329 putative PBP binding regions; other site 1271864005330 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1271864005331 catalytic residues [active] 1271864005332 dimer interface [polypeptide binding]; other site 1271864005333 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 1271864005334 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1271864005335 Walker A/P-loop; other site 1271864005336 ATP binding site [chemical binding]; other site 1271864005337 Q-loop/lid; other site 1271864005338 ABC transporter signature motif; other site 1271864005339 Walker B; other site 1271864005340 D-loop; other site 1271864005341 H-loop/switch region; other site 1271864005342 NlpC/P60 family; Region: NLPC_P60; pfam00877 1271864005343 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1271864005344 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1271864005345 hypothetical protein; Validated; Region: PRK00029 1271864005346 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1271864005347 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1271864005348 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1271864005349 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1271864005350 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1271864005351 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1271864005352 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1271864005353 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1271864005354 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1271864005355 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1271864005356 acyl-activating enzyme (AAE) consensus motif; other site 1271864005357 putative AMP binding site [chemical binding]; other site 1271864005358 putative active site [active] 1271864005359 putative CoA binding site [chemical binding]; other site 1271864005360 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1271864005361 oxidoreductase; Provisional; Region: PRK10015 1271864005362 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1271864005363 Electron transfer flavoprotein domain; Region: ETF; smart00893 1271864005364 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1271864005365 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1271864005366 Ligand binding site [chemical binding]; other site 1271864005367 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1271864005368 Cupin domain; Region: Cupin_2; pfam07883 1271864005369 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864005370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864005371 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1271864005372 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1271864005373 active site 1271864005374 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1271864005375 Coenzyme A transferase; Region: CoA_trans; smart00882 1271864005376 Coenzyme A transferase; Region: CoA_trans; cl17247 1271864005377 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1271864005378 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1271864005379 active site 1271864005380 catalytic residue [active] 1271864005381 dimer interface [polypeptide binding]; other site 1271864005382 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1271864005383 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1271864005384 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1271864005385 shikimate binding site; other site 1271864005386 NAD(P) binding site [chemical binding]; other site 1271864005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864005389 putative substrate translocation pore; other site 1271864005390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864005392 putative substrate translocation pore; other site 1271864005393 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1271864005394 putative inner membrane protein; Provisional; Region: PRK10983 1271864005395 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1271864005396 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1271864005397 FAD binding domain; Region: FAD_binding_4; pfam01565 1271864005398 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1271864005399 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1271864005400 CoenzymeA binding site [chemical binding]; other site 1271864005401 subunit interaction site [polypeptide binding]; other site 1271864005402 PHB binding site; other site 1271864005403 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1271864005404 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1271864005405 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1271864005406 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1271864005407 putative ABC transporter; Region: ycf24; CHL00085 1271864005408 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1271864005409 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1271864005410 Walker A/P-loop; other site 1271864005411 ATP binding site [chemical binding]; other site 1271864005412 Q-loop/lid; other site 1271864005413 ABC transporter signature motif; other site 1271864005414 Walker B; other site 1271864005415 D-loop; other site 1271864005416 H-loop/switch region; other site 1271864005417 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1271864005418 FeS assembly protein SufD; Region: sufD; TIGR01981 1271864005419 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1271864005420 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1271864005421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864005422 catalytic residue [active] 1271864005423 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1271864005424 L,D-transpeptidase; Provisional; Region: PRK10190 1271864005425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864005426 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1271864005427 murein lipoprotein; Provisional; Region: PRK15396 1271864005428 murein lipoprotein; Provisional; Region: PRK15396 1271864005429 murein lipoprotein; Provisional; Region: PRK15396 1271864005430 pyruvate kinase; Provisional; Region: PRK09206 1271864005431 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1271864005432 domain interfaces; other site 1271864005433 active site 1271864005434 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1271864005435 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1271864005436 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1271864005437 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864005438 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1271864005439 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864005440 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1271864005441 substrate binding site [chemical binding]; other site 1271864005442 dimer interface [polypeptide binding]; other site 1271864005443 ATP binding site [chemical binding]; other site 1271864005444 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1271864005445 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1271864005446 putative [Fe4-S4] binding site [ion binding]; other site 1271864005447 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864005448 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1271864005449 putative molybdopterin cofactor binding site; other site 1271864005450 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1271864005451 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1271864005452 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1271864005453 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864005454 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1271864005455 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1271864005456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1271864005457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864005458 dimer interface [polypeptide binding]; other site 1271864005459 phosphorylation site [posttranslational modification] 1271864005460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864005461 ATP binding site [chemical binding]; other site 1271864005462 Mg2+ binding site [ion binding]; other site 1271864005463 G-X-G motif; other site 1271864005464 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1271864005465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864005466 active site 1271864005467 phosphorylation site [posttranslational modification] 1271864005468 intermolecular recognition site; other site 1271864005469 dimerization interface [polypeptide binding]; other site 1271864005470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864005471 DNA binding residues [nucleotide binding] 1271864005472 dimerization interface [polypeptide binding]; other site 1271864005473 hypothetical protein; Provisional; Region: PRK10292 1271864005474 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1271864005475 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1271864005476 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1271864005477 transcriptional regulator MirA; Provisional; Region: PRK15043 1271864005478 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1271864005479 DNA binding residues [nucleotide binding] 1271864005480 two component system sensor kinase SsrB; Provisional; Region: PRK15369 1271864005481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864005482 active site 1271864005483 phosphorylation site [posttranslational modification] 1271864005484 intermolecular recognition site; other site 1271864005485 dimerization interface [polypeptide binding]; other site 1271864005486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864005487 DNA binding residues [nucleotide binding] 1271864005488 dimerization interface [polypeptide binding]; other site 1271864005489 two component system sensor kinase SsrA; Provisional; Region: PRK15347 1271864005490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864005491 dimerization interface [polypeptide binding]; other site 1271864005492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864005493 dimer interface [polypeptide binding]; other site 1271864005494 phosphorylation site [posttranslational modification] 1271864005495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864005496 ATP binding site [chemical binding]; other site 1271864005497 Mg2+ binding site [ion binding]; other site 1271864005498 G-X-G motif; other site 1271864005499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864005500 active site 1271864005501 phosphorylation site [posttranslational modification] 1271864005502 intermolecular recognition site; other site 1271864005503 dimerization interface [polypeptide binding]; other site 1271864005504 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 1271864005505 outer membrane secretin SsaC; Provisional; Region: PRK15346 1271864005506 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1271864005507 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1271864005508 type III secretion system protein SsaD; Provisional; Region: PRK15367 1271864005509 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1271864005510 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 1271864005511 type III secretion system chaperone SseA; Provisional; Region: PRK15365 1271864005512 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 1271864005513 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 1271864005514 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 1271864005515 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 1271864005516 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 1271864005517 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 1271864005518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1271864005519 TPR motif; other site 1271864005520 binding surface 1271864005521 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 1271864005522 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 1271864005523 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 1271864005524 type III secretion system protein SsaH; Provisional; Region: PRK15356 1271864005525 type III secretion system protein SsaI; Provisional; Region: PRK15355 1271864005526 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 1271864005527 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 1271864005528 type III secretion system protein SsaK; Provisional; Region: PRK15354 1271864005529 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1271864005530 type III secretion system protein SsaL; Provisional; Region: PRK15345 1271864005531 HrpJ-like domain; Region: HrpJ; pfam07201 1271864005532 TyeA; Region: TyeA; cl07611 1271864005533 type III secretion system protein SsaM; Provisional; Region: PRK15353 1271864005534 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 1271864005535 FHIPEP family; Region: FHIPEP; pfam00771 1271864005536 type III secretion system ATPase SsaN; Validated; Region: PRK07594 1271864005537 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1271864005538 Walker A motif; other site 1271864005539 ATP binding site [chemical binding]; other site 1271864005540 Walker B motif; other site 1271864005541 type III secretion system protein SsaO; Provisional; Region: PRK15352 1271864005542 type III secretion system protein SsaP; Provisional; Region: PRK15351 1271864005543 type III secretion system protein SsaQ; Validated; Region: PRK08035 1271864005544 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1271864005545 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 1271864005546 type III secretion system protein SsaS; Provisional; Region: PRK15350 1271864005547 type III secretion system protein SsaT; Provisional; Region: PRK15349 1271864005548 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 1271864005549 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1271864005550 multidrug efflux protein; Reviewed; Region: PRK01766 1271864005551 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1271864005552 cation binding site [ion binding]; other site 1271864005553 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1271864005554 Lumazine binding domain; Region: Lum_binding; pfam00677 1271864005555 Lumazine binding domain; Region: Lum_binding; pfam00677 1271864005556 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1271864005557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864005558 S-adenosylmethionine binding site [chemical binding]; other site 1271864005559 putative transporter; Provisional; Region: PRK11043 1271864005560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005561 putative substrate translocation pore; other site 1271864005562 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1271864005563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864005564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864005565 dimerization interface [polypeptide binding]; other site 1271864005566 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1271864005567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864005568 DNA binding site [nucleotide binding] 1271864005569 domain linker motif; other site 1271864005570 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1271864005571 dimerization interface [polypeptide binding]; other site 1271864005572 ligand binding site [chemical binding]; other site 1271864005573 superoxide dismutase; Provisional; Region: PRK10543 1271864005574 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1271864005575 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1271864005576 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1271864005577 NlpC/P60 family; Region: NLPC_P60; pfam00877 1271864005578 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1271864005579 putative GSH binding site [chemical binding]; other site 1271864005580 catalytic residues [active] 1271864005581 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1271864005582 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1271864005583 dimer interface [polypeptide binding]; other site 1271864005584 catalytic site [active] 1271864005585 putative active site [active] 1271864005586 putative substrate binding site [chemical binding]; other site 1271864005587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1271864005588 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1271864005589 dimer interface [polypeptide binding]; other site 1271864005590 active site 1271864005591 metal binding site [ion binding]; metal-binding site 1271864005592 glutathione binding site [chemical binding]; other site 1271864005593 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1271864005594 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1271864005595 FMN binding site [chemical binding]; other site 1271864005596 active site 1271864005597 substrate binding site [chemical binding]; other site 1271864005598 catalytic residue [active] 1271864005599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1271864005600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864005601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864005602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864005603 active site 1271864005604 catalytic tetrad [active] 1271864005605 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1271864005606 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1271864005607 E-class dimer interface [polypeptide binding]; other site 1271864005608 P-class dimer interface [polypeptide binding]; other site 1271864005609 active site 1271864005610 Cu2+ binding site [ion binding]; other site 1271864005611 Zn2+ binding site [ion binding]; other site 1271864005612 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1271864005613 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1271864005614 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1271864005615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864005616 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864005617 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1271864005618 transcriptional regulator SlyA; Provisional; Region: PRK03573 1271864005619 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1271864005620 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1271864005621 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1271864005622 lysozyme inhibitor; Provisional; Region: PRK11372 1271864005623 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1271864005624 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1271864005625 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1271864005626 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1271864005627 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1271864005628 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1271864005629 active site 1271864005630 HIGH motif; other site 1271864005631 dimer interface [polypeptide binding]; other site 1271864005632 KMSKS motif; other site 1271864005633 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864005634 RNA binding surface [nucleotide binding]; other site 1271864005635 pyridoxamine kinase; Validated; Region: PRK05756 1271864005636 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1271864005637 dimer interface [polypeptide binding]; other site 1271864005638 pyridoxal binding site [chemical binding]; other site 1271864005639 ATP binding site [chemical binding]; other site 1271864005640 glutathionine S-transferase; Provisional; Region: PRK10542 1271864005641 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1271864005642 C-terminal domain interface [polypeptide binding]; other site 1271864005643 GSH binding site (G-site) [chemical binding]; other site 1271864005644 dimer interface [polypeptide binding]; other site 1271864005645 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1271864005646 dimer interface [polypeptide binding]; other site 1271864005647 N-terminal domain interface [polypeptide binding]; other site 1271864005648 substrate binding pocket (H-site) [chemical binding]; other site 1271864005649 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1271864005650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005651 putative substrate translocation pore; other site 1271864005652 POT family; Region: PTR2; pfam00854 1271864005653 endonuclease III; Provisional; Region: PRK10702 1271864005654 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1271864005655 minor groove reading motif; other site 1271864005656 helix-hairpin-helix signature motif; other site 1271864005657 substrate binding pocket [chemical binding]; other site 1271864005658 active site 1271864005659 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1271864005660 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1271864005661 electron transport complex protein RnfG; Validated; Region: PRK01908 1271864005662 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1271864005663 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1271864005664 SLBB domain; Region: SLBB; pfam10531 1271864005665 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1271864005666 electron transport complex protein RnfB; Provisional; Region: PRK05113 1271864005667 Putative Fe-S cluster; Region: FeS; cl17515 1271864005668 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864005669 electron transport complex protein RsxA; Provisional; Region: PRK05151 1271864005670 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1271864005671 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1271864005672 putative oxidoreductase; Provisional; Region: PRK11579 1271864005673 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1271864005674 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1271864005675 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1271864005676 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1271864005677 active site 1271864005678 purine riboside binding site [chemical binding]; other site 1271864005679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1271864005680 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1271864005681 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1271864005682 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1271864005683 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1271864005684 fumarate hydratase; Provisional; Region: PRK15389 1271864005685 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1271864005686 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1271864005687 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1271864005688 Class II fumarases; Region: Fumarase_classII; cd01362 1271864005689 active site 1271864005690 tetramer interface [polypeptide binding]; other site 1271864005691 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1271864005692 sensor protein RstB; Provisional; Region: PRK10604 1271864005693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864005694 dimerization interface [polypeptide binding]; other site 1271864005695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864005696 dimer interface [polypeptide binding]; other site 1271864005697 phosphorylation site [posttranslational modification] 1271864005698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864005699 ATP binding site [chemical binding]; other site 1271864005700 Mg2+ binding site [ion binding]; other site 1271864005701 G-X-G motif; other site 1271864005702 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1271864005703 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1271864005704 active site 1271864005705 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864005706 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1271864005707 trimer interface [polypeptide binding]; other site 1271864005708 eyelet of channel; other site 1271864005709 Domain of unknown function (DUF1744); Region: DUF1744; pfam08490 1271864005710 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1271864005711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864005712 active site 1271864005713 phosphorylation site [posttranslational modification] 1271864005714 intermolecular recognition site; other site 1271864005715 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864005716 DNA binding site [nucleotide binding] 1271864005717 GlpM protein; Region: GlpM; pfam06942 1271864005718 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1271864005719 Spore germination protein; Region: Spore_permease; cl17796 1271864005720 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864005721 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864005722 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864005723 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1271864005724 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1271864005725 ligand binding site [chemical binding]; other site 1271864005726 homodimer interface [polypeptide binding]; other site 1271864005727 NAD(P) binding site [chemical binding]; other site 1271864005728 trimer interface B [polypeptide binding]; other site 1271864005729 trimer interface A [polypeptide binding]; other site 1271864005730 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1271864005731 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1271864005732 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1271864005733 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1271864005734 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1271864005735 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1271864005736 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1271864005737 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1271864005738 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1271864005739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005740 putative substrate translocation pore; other site 1271864005741 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1271864005742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864005743 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1271864005744 dimerization interface [polypeptide binding]; other site 1271864005745 substrate binding pocket [chemical binding]; other site 1271864005746 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1271864005747 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1271864005748 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864005749 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1271864005750 AAA domain; Region: AAA_26; pfam13500 1271864005751 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1271864005752 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1271864005753 Cl- selectivity filter; other site 1271864005754 Cl- binding residues [ion binding]; other site 1271864005755 pore gating glutamate residue; other site 1271864005756 dimer interface [polypeptide binding]; other site 1271864005757 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1271864005758 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1271864005759 Walker A/P-loop; other site 1271864005760 ATP binding site [chemical binding]; other site 1271864005761 Q-loop/lid; other site 1271864005762 ABC transporter signature motif; other site 1271864005763 Walker B; other site 1271864005764 D-loop; other site 1271864005765 H-loop/switch region; other site 1271864005766 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1271864005767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864005768 dimer interface [polypeptide binding]; other site 1271864005769 conserved gate region; other site 1271864005770 ABC-ATPase subunit interface; other site 1271864005771 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1271864005772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864005773 dimer interface [polypeptide binding]; other site 1271864005774 conserved gate region; other site 1271864005775 putative PBP binding loops; other site 1271864005776 ABC-ATPase subunit interface; other site 1271864005777 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1271864005778 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1271864005779 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1271864005780 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864005781 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1271864005782 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1271864005783 putative [Fe4-S4] binding site [ion binding]; other site 1271864005784 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864005785 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1271864005786 putative molybdopterin cofactor binding site; other site 1271864005787 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1271864005788 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1271864005789 putative [Fe4-S4] binding site [ion binding]; other site 1271864005790 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864005791 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1271864005792 putative molybdopterin cofactor binding site; other site 1271864005793 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1271864005794 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1271864005795 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1271864005796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864005797 Coenzyme A binding pocket [chemical binding]; other site 1271864005798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1271864005799 hypothetical protein; Provisional; Region: PRK13659 1271864005800 hypothetical protein; Provisional; Region: PRK02237 1271864005801 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1271864005802 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1271864005803 putative active site pocket [active] 1271864005804 putative metal binding site [ion binding]; other site 1271864005805 putative oxidoreductase; Provisional; Region: PRK10083 1271864005806 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1271864005807 putative NAD(P) binding site [chemical binding]; other site 1271864005808 catalytic Zn binding site [ion binding]; other site 1271864005809 structural Zn binding site [ion binding]; other site 1271864005810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005811 metabolite-proton symporter; Region: 2A0106; TIGR00883 1271864005812 putative substrate translocation pore; other site 1271864005813 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1271864005814 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1271864005815 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1271864005816 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1271864005817 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1271864005818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864005819 DNA-binding site [nucleotide binding]; DNA binding site 1271864005820 FCD domain; Region: FCD; pfam07729 1271864005821 malonic semialdehyde reductase; Provisional; Region: PRK10538 1271864005822 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1271864005823 putative NAD(P) binding site [chemical binding]; other site 1271864005824 homodimer interface [polypeptide binding]; other site 1271864005825 homotetramer interface [polypeptide binding]; other site 1271864005826 active site 1271864005827 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1271864005828 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1271864005829 active site 1271864005830 Zn binding site [ion binding]; other site 1271864005831 General stress protein [General function prediction only]; Region: GsiB; COG3729 1271864005832 hypothetical protein; Validated; Region: PRK03657 1271864005833 hypothetical protein; Provisional; Region: PRK10053 1271864005834 putative transporter; Provisional; Region: PRK10054 1271864005835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005836 putative substrate translocation pore; other site 1271864005837 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1271864005838 EamA-like transporter family; Region: EamA; pfam00892 1271864005839 MarB protein; Region: MarB; pfam13999 1271864005840 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1271864005841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864005842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864005843 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1271864005844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1271864005845 inner membrane protein; Provisional; Region: PRK10995 1271864005846 putative arabinose transporter; Provisional; Region: PRK03545 1271864005847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005848 putative substrate translocation pore; other site 1271864005849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864005850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864005851 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1271864005852 putative dimerization interface [polypeptide binding]; other site 1271864005853 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1271864005854 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1271864005855 NAD(P) binding site [chemical binding]; other site 1271864005856 catalytic residues [active] 1271864005857 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1271864005858 glutaminase; Provisional; Region: PRK00971 1271864005859 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1271864005860 Predicted membrane protein [Function unknown]; Region: COG3781 1271864005861 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1271864005862 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864005863 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1271864005864 trimer interface [polypeptide binding]; other site 1271864005865 eyelet of channel; other site 1271864005866 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1271864005867 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1271864005868 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1271864005869 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1271864005870 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1271864005871 Rubredoxin [Energy production and conversion]; Region: COG1773 1271864005872 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1271864005873 iron binding site [ion binding]; other site 1271864005874 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1271864005875 HupF/HypC family; Region: HupF_HypC; cl00394 1271864005876 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1271864005877 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1271864005878 putative substrate-binding site; other site 1271864005879 nickel binding site [ion binding]; other site 1271864005880 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 1271864005881 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1271864005882 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1271864005883 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1271864005884 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1271864005885 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1271864005886 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1271864005887 active site 1271864005888 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1271864005889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864005890 DNA-binding site [nucleotide binding]; DNA binding site 1271864005891 FCD domain; Region: FCD; pfam07729 1271864005892 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1271864005893 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1271864005894 putative NAD(P) binding site [chemical binding]; other site 1271864005895 catalytic Zn binding site [ion binding]; other site 1271864005896 structural Zn binding site [ion binding]; other site 1271864005897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005898 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864005899 putative substrate translocation pore; other site 1271864005900 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 1271864005901 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1271864005902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864005904 putative substrate translocation pore; other site 1271864005905 hypothetical protein; Provisional; Region: PRK06184 1271864005906 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1271864005907 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1271864005908 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1271864005909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864005910 putative DNA binding site [nucleotide binding]; other site 1271864005911 putative Zn2+ binding site [ion binding]; other site 1271864005912 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1271864005913 homotrimer interaction site [polypeptide binding]; other site 1271864005914 putative active site [active] 1271864005915 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1271864005916 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1271864005917 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1271864005918 Winged helix-turn helix; Region: HTH_29; pfam13551 1271864005919 Helix-turn-helix domain; Region: HTH_28; pfam13518 1271864005920 Homeodomain-like domain; Region: HTH_32; pfam13565 1271864005921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864005922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864005923 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1271864005924 putative effector binding pocket; other site 1271864005925 putative dimerization interface [polypeptide binding]; other site 1271864005926 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1271864005927 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1271864005928 FMN binding site [chemical binding]; other site 1271864005929 substrate binding site [chemical binding]; other site 1271864005930 putative catalytic residue [active] 1271864005931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1271864005932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864005933 DNA binding site [nucleotide binding] 1271864005934 domain linker motif; other site 1271864005935 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1271864005936 dimerization interface (closed form) [polypeptide binding]; other site 1271864005937 ligand binding site [chemical binding]; other site 1271864005938 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1271864005939 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1271864005940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864005941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864005942 homodimer interface [polypeptide binding]; other site 1271864005943 catalytic residue [active] 1271864005944 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1271864005945 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1271864005946 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1271864005947 active site 1271864005948 catalytic site [active] 1271864005949 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1271864005950 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1271864005951 active site 1271864005952 catalytic site [active] 1271864005953 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1271864005954 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1271864005955 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1271864005956 catalytic site [active] 1271864005957 active site 1271864005958 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1271864005959 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1271864005960 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1271864005961 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1271864005962 biofilm-dependent modulation protein; Provisional; Region: PRK11436 1271864005963 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1271864005964 malate dehydrogenase; Provisional; Region: PRK13529 1271864005965 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1271864005966 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1271864005967 NAD(P) binding site [chemical binding]; other site 1271864005968 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1271864005969 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1271864005970 NAD binding site [chemical binding]; other site 1271864005971 substrate binding site [chemical binding]; other site 1271864005972 catalytic Zn binding site [ion binding]; other site 1271864005973 tetramer interface [polypeptide binding]; other site 1271864005974 structural Zn binding site [ion binding]; other site 1271864005975 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1271864005976 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1271864005977 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1271864005978 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1271864005979 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864005980 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864005981 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1271864005982 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1271864005983 molybdopterin cofactor binding site; other site 1271864005984 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864005985 aromatic amino acid exporter; Provisional; Region: PRK11689 1271864005986 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864005987 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1271864005988 trimer interface [polypeptide binding]; other site 1271864005989 eyelet of channel; other site 1271864005990 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1271864005991 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1271864005992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864005993 putative substrate translocation pore; other site 1271864005994 TetR family transcriptional regulator; Provisional; Region: PRK14996 1271864005995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864005996 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1271864005997 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1271864005998 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1271864005999 [4Fe-4S] binding site [ion binding]; other site 1271864006000 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864006001 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864006002 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864006003 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1271864006004 molybdopterin cofactor binding site; other site 1271864006005 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1271864006006 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1271864006007 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1271864006008 hypothetical protein; Provisional; Region: PRK10281 1271864006009 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1271864006010 L-asparagine permease; Provisional; Region: PRK15049 1271864006011 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1271864006012 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1271864006013 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1271864006014 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1271864006015 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864006016 N-terminal plug; other site 1271864006017 ligand-binding site [chemical binding]; other site 1271864006018 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1271864006019 DNA-binding site [nucleotide binding]; DNA binding site 1271864006020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1271864006021 FCD domain; Region: FCD; pfam07729 1271864006022 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1271864006023 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1271864006024 NAD(P) binding site [chemical binding]; other site 1271864006025 substrate binding site [chemical binding]; other site 1271864006026 dimer interface [polypeptide binding]; other site 1271864006027 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1271864006028 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1271864006029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1271864006030 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1271864006031 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 1271864006032 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1271864006033 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1271864006034 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1271864006035 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1271864006036 tetrameric interface [polypeptide binding]; other site 1271864006037 NAD binding site [chemical binding]; other site 1271864006038 catalytic residues [active] 1271864006039 substrate binding site [chemical binding]; other site 1271864006040 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1271864006041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864006042 DNA-binding site [nucleotide binding]; DNA binding site 1271864006043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864006044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864006045 homodimer interface [polypeptide binding]; other site 1271864006046 catalytic residue [active] 1271864006047 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 1271864006048 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 1271864006049 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1271864006050 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1271864006051 Peptidase family U32; Region: Peptidase_U32; pfam01136 1271864006052 Collagenase; Region: DUF3656; pfam12392 1271864006053 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1271864006054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864006055 non-specific DNA binding site [nucleotide binding]; other site 1271864006056 salt bridge; other site 1271864006057 sequence-specific DNA binding site [nucleotide binding]; other site 1271864006058 Cupin domain; Region: Cupin_2; pfam07883 1271864006059 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1271864006060 benzoate transporter; Region: benE; TIGR00843 1271864006061 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1271864006062 tellurite resistance protein TehB; Provisional; Region: PRK11207 1271864006063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864006064 S-adenosylmethionine binding site [chemical binding]; other site 1271864006065 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1271864006066 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1271864006067 gating phenylalanine in ion channel; other site 1271864006068 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1271864006069 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1271864006070 putative trimer interface [polypeptide binding]; other site 1271864006071 putative CoA binding site [chemical binding]; other site 1271864006072 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1271864006073 putative trimer interface [polypeptide binding]; other site 1271864006074 putative CoA binding site [chemical binding]; other site 1271864006075 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1271864006076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864006077 Coenzyme A binding pocket [chemical binding]; other site 1271864006078 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1271864006079 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1271864006080 oligomer interface [polypeptide binding]; other site 1271864006081 active site 1271864006082 metal binding site [ion binding]; metal-binding site 1271864006083 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1271864006084 active site 1271864006085 P-loop; other site 1271864006086 phosphorylation site [posttranslational modification] 1271864006087 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1271864006088 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1271864006089 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1271864006090 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864006091 active site 1271864006092 phosphorylation site [posttranslational modification] 1271864006093 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1271864006094 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1271864006095 substrate binding site [chemical binding]; other site 1271864006096 hexamer interface [polypeptide binding]; other site 1271864006097 metal binding site [ion binding]; metal-binding site 1271864006098 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864006099 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1271864006100 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864006101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864006102 Coenzyme A binding pocket [chemical binding]; other site 1271864006103 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1271864006104 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1271864006105 teramer interface [polypeptide binding]; other site 1271864006106 active site 1271864006107 FMN binding site [chemical binding]; other site 1271864006108 catalytic residues [active] 1271864006109 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1271864006110 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1271864006111 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1271864006112 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1271864006113 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1271864006114 substrate binding pocket [chemical binding]; other site 1271864006115 catalytic triad [active] 1271864006116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1271864006117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1271864006118 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1271864006119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864006120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864006121 dimerization interface [polypeptide binding]; other site 1271864006122 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1271864006123 dimer interface [polypeptide binding]; other site 1271864006124 ligand binding site [chemical binding]; other site 1271864006125 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1271864006126 HAMP domain; Region: HAMP; pfam00672 1271864006127 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864006128 dimer interface [polypeptide binding]; other site 1271864006129 putative CheW interface [polypeptide binding]; other site 1271864006130 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1271864006131 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1271864006132 substrate binding site [chemical binding]; other site 1271864006133 catalytic Zn binding site [ion binding]; other site 1271864006134 NAD binding site [chemical binding]; other site 1271864006135 structural Zn binding site [ion binding]; other site 1271864006136 dimer interface [polypeptide binding]; other site 1271864006137 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1271864006138 putative metal binding site [ion binding]; other site 1271864006139 putative homodimer interface [polypeptide binding]; other site 1271864006140 putative homotetramer interface [polypeptide binding]; other site 1271864006141 putative homodimer-homodimer interface [polypeptide binding]; other site 1271864006142 putative allosteric switch controlling residues; other site 1271864006143 Sif protein; Region: Sif; cl11505 1271864006144 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1271864006145 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1271864006146 active site 1271864006147 catalytic triad [active] 1271864006148 oxyanion hole [active] 1271864006149 Predicted membrane protein [Function unknown]; Region: COG3326 1271864006150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864006151 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1271864006152 substrate binding pocket [chemical binding]; other site 1271864006153 membrane-bound complex binding site; other site 1271864006154 hinge residues; other site 1271864006155 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864006156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864006157 dimer interface [polypeptide binding]; other site 1271864006158 conserved gate region; other site 1271864006159 putative PBP binding loops; other site 1271864006160 ABC-ATPase subunit interface; other site 1271864006161 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1271864006162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864006163 Walker A/P-loop; other site 1271864006164 ATP binding site [chemical binding]; other site 1271864006165 Q-loop/lid; other site 1271864006166 ABC transporter signature motif; other site 1271864006167 Walker B; other site 1271864006168 D-loop; other site 1271864006169 H-loop/switch region; other site 1271864006170 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864006171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864006172 dimer interface [polypeptide binding]; other site 1271864006173 conserved gate region; other site 1271864006174 putative PBP binding loops; other site 1271864006175 ABC-ATPase subunit interface; other site 1271864006176 Predicted membrane protein [Function unknown]; Region: COG5305 1271864006177 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1271864006178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864006179 S-adenosylmethionine binding site [chemical binding]; other site 1271864006180 cytochrome b561; Provisional; Region: PRK11513 1271864006181 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1271864006182 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1271864006183 putative active site [active] 1271864006184 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1271864006185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864006186 ATP binding site [chemical binding]; other site 1271864006187 putative Mg++ binding site [ion binding]; other site 1271864006188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864006189 nucleotide binding region [chemical binding]; other site 1271864006190 ATP-binding site [chemical binding]; other site 1271864006191 Helicase associated domain (HA2); Region: HA2; pfam04408 1271864006192 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1271864006193 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1271864006194 azoreductase; Reviewed; Region: PRK00170 1271864006195 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1271864006196 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1271864006197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1271864006198 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1271864006199 hypothetical protein; Provisional; Region: PRK10695 1271864006200 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1271864006201 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1271864006202 putative ligand binding site [chemical binding]; other site 1271864006203 putative NAD binding site [chemical binding]; other site 1271864006204 catalytic site [active] 1271864006205 heat-inducible protein; Provisional; Region: PRK10449 1271864006206 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1271864006207 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1271864006208 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1271864006209 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1271864006210 dimer interface [polypeptide binding]; other site 1271864006211 PYR/PP interface [polypeptide binding]; other site 1271864006212 TPP binding site [chemical binding]; other site 1271864006213 substrate binding site [chemical binding]; other site 1271864006214 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1271864006215 Domain of unknown function; Region: EKR; smart00890 1271864006216 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1271864006217 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864006218 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1271864006219 TPP-binding site [chemical binding]; other site 1271864006220 dimer interface [polypeptide binding]; other site 1271864006221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1271864006222 Ligand Binding Site [chemical binding]; other site 1271864006223 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1271864006224 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1271864006225 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1271864006226 Ligand Binding Site [chemical binding]; other site 1271864006227 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1271864006228 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1271864006229 ATP binding site [chemical binding]; other site 1271864006230 Mg++ binding site [ion binding]; other site 1271864006231 motif III; other site 1271864006232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864006233 nucleotide binding region [chemical binding]; other site 1271864006234 ATP-binding site [chemical binding]; other site 1271864006235 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1271864006236 putative RNA binding site [nucleotide binding]; other site 1271864006237 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1271864006238 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1271864006239 Cl binding site [ion binding]; other site 1271864006240 oligomer interface [polypeptide binding]; other site 1271864006241 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1271864006242 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864006243 dimer interface [polypeptide binding]; other site 1271864006244 putative CheW interface [polypeptide binding]; other site 1271864006245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1271864006246 Smr domain; Region: Smr; pfam01713 1271864006247 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1271864006248 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1271864006249 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1271864006250 DNA binding site [nucleotide binding] 1271864006251 active site 1271864006252 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1271864006253 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1271864006254 ligand binding site [chemical binding]; other site 1271864006255 flexible hinge region; other site 1271864006256 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1271864006257 putative switch regulator; other site 1271864006258 non-specific DNA interactions [nucleotide binding]; other site 1271864006259 DNA binding site [nucleotide binding] 1271864006260 sequence specific DNA binding site [nucleotide binding]; other site 1271864006261 putative cAMP binding site [chemical binding]; other site 1271864006262 universal stress protein UspE; Provisional; Region: PRK11175 1271864006263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1271864006264 Ligand Binding Site [chemical binding]; other site 1271864006265 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1271864006266 Ligand Binding Site [chemical binding]; other site 1271864006267 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1271864006268 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1271864006269 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864006270 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1271864006271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864006272 non-specific DNA binding site [nucleotide binding]; other site 1271864006273 salt bridge; other site 1271864006274 sequence-specific DNA binding site [nucleotide binding]; other site 1271864006275 Cupin domain; Region: Cupin_2; pfam07883 1271864006276 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1271864006277 B3/4 domain; Region: B3_4; pfam03483 1271864006278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1271864006279 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1271864006280 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1271864006281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864006282 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1271864006283 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1271864006284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1271864006285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864006286 oxidoreductase; Provisional; Region: PRK12742 1271864006287 classical (c) SDRs; Region: SDR_c; cd05233 1271864006288 NAD(P) binding site [chemical binding]; other site 1271864006289 active site 1271864006290 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864006291 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864006292 active site 1271864006293 catalytic tetrad [active] 1271864006294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864006295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864006296 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1271864006297 putative effector binding pocket; other site 1271864006298 putative dimerization interface [polypeptide binding]; other site 1271864006299 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1271864006300 NmrA-like family; Region: NmrA; pfam05368 1271864006301 NAD(P) binding site [chemical binding]; other site 1271864006302 active site lysine 1271864006303 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1271864006304 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1271864006305 peptide binding site [polypeptide binding]; other site 1271864006306 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1271864006307 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1271864006308 putative active site [active] 1271864006309 Zn binding site [ion binding]; other site 1271864006310 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1271864006311 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1271864006312 active site 1271864006313 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1271864006314 dimer interface [polypeptide binding]; other site 1271864006315 catalytic triad [active] 1271864006316 peroxidatic and resolving cysteines [active] 1271864006317 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1271864006318 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1271864006319 putative aromatic amino acid binding site; other site 1271864006320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864006321 Walker A motif; other site 1271864006322 ATP binding site [chemical binding]; other site 1271864006323 Walker B motif; other site 1271864006324 arginine finger; other site 1271864006325 hypothetical protein; Provisional; Region: PRK05415 1271864006326 TIGR01620 family protein; Region: hyp_HI0043 1271864006327 Predicted ATPase [General function prediction only]; Region: COG3106 1271864006328 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1271864006329 active site residue [active] 1271864006330 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1271864006331 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1271864006332 phage shock protein C; Region: phageshock_pspC; TIGR02978 1271864006333 phage shock protein B; Provisional; Region: pspB; PRK09458 1271864006334 phage shock protein PspA; Provisional; Region: PRK10698 1271864006335 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1271864006336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864006337 Walker A motif; other site 1271864006338 ATP binding site [chemical binding]; other site 1271864006339 Walker B motif; other site 1271864006340 arginine finger; other site 1271864006341 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1271864006342 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1271864006343 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1271864006344 peptide binding site [polypeptide binding]; other site 1271864006345 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1271864006346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864006347 dimer interface [polypeptide binding]; other site 1271864006348 conserved gate region; other site 1271864006349 putative PBP binding loops; other site 1271864006350 ABC-ATPase subunit interface; other site 1271864006351 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1271864006352 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1271864006353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864006354 dimer interface [polypeptide binding]; other site 1271864006355 conserved gate region; other site 1271864006356 putative PBP binding loops; other site 1271864006357 ABC-ATPase subunit interface; other site 1271864006358 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1271864006359 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864006360 Walker A/P-loop; other site 1271864006361 ATP binding site [chemical binding]; other site 1271864006362 Q-loop/lid; other site 1271864006363 ABC transporter signature motif; other site 1271864006364 Walker B; other site 1271864006365 D-loop; other site 1271864006366 H-loop/switch region; other site 1271864006367 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1271864006368 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1271864006369 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864006370 Walker A/P-loop; other site 1271864006371 ATP binding site [chemical binding]; other site 1271864006372 Q-loop/lid; other site 1271864006373 ABC transporter signature motif; other site 1271864006374 Walker B; other site 1271864006375 D-loop; other site 1271864006376 H-loop/switch region; other site 1271864006377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1271864006378 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1271864006379 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1271864006380 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1271864006381 NAD binding site [chemical binding]; other site 1271864006382 homotetramer interface [polypeptide binding]; other site 1271864006383 homodimer interface [polypeptide binding]; other site 1271864006384 substrate binding site [chemical binding]; other site 1271864006385 active site 1271864006386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1271864006387 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1271864006388 exoribonuclease II; Provisional; Region: PRK05054 1271864006389 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1271864006390 RNB domain; Region: RNB; pfam00773 1271864006391 S1 RNA binding domain; Region: S1; pfam00575 1271864006392 RNase II stability modulator; Provisional; Region: PRK10060 1271864006393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864006394 putative active site [active] 1271864006395 heme pocket [chemical binding]; other site 1271864006396 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864006397 metal binding site [ion binding]; metal-binding site 1271864006398 active site 1271864006399 I-site; other site 1271864006400 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864006401 hypothetical protein; Provisional; Region: PRK13658 1271864006402 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864006403 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1271864006404 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864006405 lipoprotein; Provisional; Region: PRK10540 1271864006406 translation initiation factor Sui1; Validated; Region: PRK06824 1271864006407 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1271864006408 putative rRNA binding site [nucleotide binding]; other site 1271864006409 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1271864006410 active site 1271864006411 dimer interface [polypeptide binding]; other site 1271864006412 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1271864006413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1271864006414 TPR motif; other site 1271864006415 binding surface 1271864006416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1271864006417 binding surface 1271864006418 TPR motif; other site 1271864006419 Predicted membrane protein [Function unknown]; Region: COG3771 1271864006420 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1271864006421 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1271864006422 active site 1271864006423 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1271864006424 dimerization interface [polypeptide binding]; other site 1271864006425 active site 1271864006426 aconitate hydratase; Validated; Region: PRK09277 1271864006427 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1271864006428 substrate binding site [chemical binding]; other site 1271864006429 ligand binding site [chemical binding]; other site 1271864006430 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1271864006431 substrate binding site [chemical binding]; other site 1271864006432 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1271864006433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864006434 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1271864006435 substrate binding site [chemical binding]; other site 1271864006436 putative dimerization interface [polypeptide binding]; other site 1271864006437 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1271864006438 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1271864006439 active site 1271864006440 interdomain interaction site; other site 1271864006441 putative metal-binding site [ion binding]; other site 1271864006442 nucleotide binding site [chemical binding]; other site 1271864006443 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1271864006444 domain I; other site 1271864006445 DNA binding groove [nucleotide binding] 1271864006446 phosphate binding site [ion binding]; other site 1271864006447 domain II; other site 1271864006448 domain III; other site 1271864006449 nucleotide binding site [chemical binding]; other site 1271864006450 catalytic site [active] 1271864006451 domain IV; other site 1271864006452 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1271864006453 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1271864006454 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1271864006455 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1271864006456 hypothetical protein; Provisional; Region: PRK11037 1271864006457 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1271864006458 putative inner membrane peptidase; Provisional; Region: PRK11778 1271864006459 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1271864006460 tandem repeat interface [polypeptide binding]; other site 1271864006461 oligomer interface [polypeptide binding]; other site 1271864006462 active site residues [active] 1271864006463 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1271864006464 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1271864006465 NADP binding site [chemical binding]; other site 1271864006466 homodimer interface [polypeptide binding]; other site 1271864006467 active site 1271864006468 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1271864006469 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1271864006470 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1271864006471 homodimer interface [polypeptide binding]; other site 1271864006472 Walker A motif; other site 1271864006473 ATP binding site [chemical binding]; other site 1271864006474 hydroxycobalamin binding site [chemical binding]; other site 1271864006475 Walker B motif; other site 1271864006476 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1271864006477 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864006478 RNA binding surface [nucleotide binding]; other site 1271864006479 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1271864006480 probable active site [active] 1271864006481 hypothetical protein; Provisional; Region: PRK11630 1271864006482 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1271864006483 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1271864006484 active site 1271864006485 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1271864006486 anthranilate synthase component I; Provisional; Region: PRK13564 1271864006487 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1271864006488 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1271864006489 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1271864006490 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1271864006491 glutamine binding [chemical binding]; other site 1271864006492 catalytic triad [active] 1271864006493 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1271864006494 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1271864006495 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1271864006496 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1271864006497 active site 1271864006498 ribulose/triose binding site [chemical binding]; other site 1271864006499 phosphate binding site [ion binding]; other site 1271864006500 substrate (anthranilate) binding pocket [chemical binding]; other site 1271864006501 product (indole) binding pocket [chemical binding]; other site 1271864006502 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1271864006503 active site 1271864006504 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1271864006505 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1271864006506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864006507 catalytic residue [active] 1271864006508 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1271864006509 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1271864006510 substrate binding site [chemical binding]; other site 1271864006511 active site 1271864006512 catalytic residues [active] 1271864006513 heterodimer interface [polypeptide binding]; other site 1271864006514 General stress protein [General function prediction only]; Region: GsiB; COG3729 1271864006515 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1271864006516 dimerization interface [polypeptide binding]; other site 1271864006517 metal binding site [ion binding]; metal-binding site 1271864006518 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1271864006519 dinuclear metal binding motif [ion binding]; other site 1271864006520 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1271864006521 dimanganese center [ion binding]; other site 1271864006522 outer membrane protein W; Provisional; Region: PRK10959 1271864006523 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1271864006524 hypothetical protein; Provisional; Region: PRK02868 1271864006525 intracellular septation protein A; Reviewed; Region: PRK00259 1271864006526 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1271864006527 transport protein TonB; Provisional; Region: PRK10819 1271864006528 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1271864006529 YciI-like protein; Reviewed; Region: PRK11370 1271864006530 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1271864006531 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1271864006532 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1271864006533 putative active site [active] 1271864006534 catalytic site [active] 1271864006535 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1271864006536 putative active site [active] 1271864006537 catalytic site [active] 1271864006538 dsDNA-mimic protein; Reviewed; Region: PRK05094 1271864006539 Ion transport protein; Region: Ion_trans; pfam00520 1271864006540 Ion channel; Region: Ion_trans_2; pfam07885 1271864006541 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1271864006542 Double zinc ribbon; Region: DZR; pfam12773 1271864006543 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1271864006544 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864006545 Walker A/P-loop; other site 1271864006546 ATP binding site [chemical binding]; other site 1271864006547 Q-loop/lid; other site 1271864006548 ABC transporter signature motif; other site 1271864006549 Walker B; other site 1271864006550 D-loop; other site 1271864006551 H-loop/switch region; other site 1271864006552 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1271864006553 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1271864006554 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864006555 Walker A/P-loop; other site 1271864006556 ATP binding site [chemical binding]; other site 1271864006557 Q-loop/lid; other site 1271864006558 ABC transporter signature motif; other site 1271864006559 Walker B; other site 1271864006560 D-loop; other site 1271864006561 H-loop/switch region; other site 1271864006562 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1271864006563 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1271864006564 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1271864006565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864006566 dimer interface [polypeptide binding]; other site 1271864006567 conserved gate region; other site 1271864006568 ABC-ATPase subunit interface; other site 1271864006569 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1271864006570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864006571 dimer interface [polypeptide binding]; other site 1271864006572 conserved gate region; other site 1271864006573 putative PBP binding loops; other site 1271864006574 ABC-ATPase subunit interface; other site 1271864006575 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1271864006576 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1271864006577 peptide binding site [polypeptide binding]; other site 1271864006578 hypothetical protein; Provisional; Region: PRK11111 1271864006579 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1271864006580 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1271864006581 putative catalytic cysteine [active] 1271864006582 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1271864006583 putative active site [active] 1271864006584 metal binding site [ion binding]; metal-binding site 1271864006585 thymidine kinase; Provisional; Region: PRK04296 1271864006586 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1271864006587 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1271864006588 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1271864006589 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1271864006590 active site 1271864006591 tetramer interface; other site 1271864006592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864006593 active site 1271864006594 response regulator of RpoS; Provisional; Region: PRK10693 1271864006595 phosphorylation site [posttranslational modification] 1271864006596 intermolecular recognition site; other site 1271864006597 dimerization interface [polypeptide binding]; other site 1271864006598 hypothetical protein; Provisional; Region: PRK10279 1271864006599 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1271864006600 active site 1271864006601 nucleophile elbow; other site 1271864006602 SEC-C motif; Region: SEC-C; pfam02810 1271864006603 hypothetical protein; Provisional; Region: PRK04233 1271864006604 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1271864006605 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1271864006606 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1271864006607 putative active site [active] 1271864006608 putative substrate binding site [chemical binding]; other site 1271864006609 putative cosubstrate binding site; other site 1271864006610 catalytic site [active] 1271864006611 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864006612 Sel1-like repeats; Region: SEL1; smart00671 1271864006613 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864006614 Sel1-like repeats; Region: SEL1; smart00671 1271864006615 Sel1-like repeats; Region: SEL1; smart00671 1271864006616 Sel1-like repeats; Region: SEL1; smart00671 1271864006617 Sel1-like repeats; Region: SEL1; smart00671 1271864006618 Sel1-like repeats; Region: SEL1; smart00671 1271864006619 Sel1-like repeats; Region: SEL1; smart00671 1271864006620 Sel1-like repeats; Region: SEL1; smart00671 1271864006621 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1271864006622 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1271864006623 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1271864006624 4Fe-4S binding domain; Region: Fer4; cl02805 1271864006625 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1271864006626 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1271864006627 [4Fe-4S] binding site [ion binding]; other site 1271864006628 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864006629 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864006630 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864006631 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1271864006632 molybdopterin cofactor binding site; other site 1271864006633 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1271864006634 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1271864006635 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1271864006636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864006637 dimerization interface [polypeptide binding]; other site 1271864006638 Histidine kinase; Region: HisKA_3; pfam07730 1271864006639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864006640 ATP binding site [chemical binding]; other site 1271864006641 Mg2+ binding site [ion binding]; other site 1271864006642 G-X-G motif; other site 1271864006643 transcriptional regulator NarL; Provisional; Region: PRK10651 1271864006644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864006645 active site 1271864006646 phosphorylation site [posttranslational modification] 1271864006647 intermolecular recognition site; other site 1271864006648 dimerization interface [polypeptide binding]; other site 1271864006649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864006650 DNA binding residues [nucleotide binding] 1271864006651 dimerization interface [polypeptide binding]; other site 1271864006652 putative invasin; Provisional; Region: PRK10177 1271864006653 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1271864006654 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1271864006655 cation transport regulator; Reviewed; Region: chaB; PRK09582 1271864006656 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1271864006657 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1271864006658 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 1271864006659 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1271864006660 hypothetical protein; Provisional; Region: PRK10941 1271864006661 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1271864006662 hypothetical protein; Provisional; Region: PRK10278 1271864006663 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1271864006664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864006665 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1271864006666 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1271864006667 RF-1 domain; Region: RF-1; pfam00472 1271864006668 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1271864006669 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1271864006670 tRNA; other site 1271864006671 putative tRNA binding site [nucleotide binding]; other site 1271864006672 putative NADP binding site [chemical binding]; other site 1271864006673 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1271864006674 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1271864006675 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1271864006676 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1271864006677 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1271864006678 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1271864006679 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1271864006680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864006681 active site 1271864006682 putative transporter; Provisional; Region: PRK11660 1271864006683 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1271864006684 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1271864006685 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1271864006686 hypothetical protein; Provisional; Region: PRK10692 1271864006687 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1271864006688 putative active site [active] 1271864006689 catalytic residue [active] 1271864006690 GTP-binding protein YchF; Reviewed; Region: PRK09601 1271864006691 YchF GTPase; Region: YchF; cd01900 1271864006692 G1 box; other site 1271864006693 GTP/Mg2+ binding site [chemical binding]; other site 1271864006694 Switch I region; other site 1271864006695 G2 box; other site 1271864006696 Switch II region; other site 1271864006697 G3 box; other site 1271864006698 G4 box; other site 1271864006699 G5 box; other site 1271864006700 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1271864006701 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 1271864006702 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 1271864006703 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1271864006704 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1271864006705 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1271864006706 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1271864006707 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1271864006708 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1271864006709 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1271864006710 putative substrate-binding site; other site 1271864006711 nickel binding site [ion binding]; other site 1271864006712 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1271864006713 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1271864006714 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1271864006715 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1271864006716 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1271864006717 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1271864006718 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1271864006719 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1271864006720 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1271864006721 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1271864006722 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1271864006723 NAD(P) binding site [chemical binding]; other site 1271864006724 trehalase; Provisional; Region: treA; PRK13271 1271864006725 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1271864006726 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1271864006727 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1271864006728 Flagellar regulator YcgR; Region: YcgR; pfam07317 1271864006729 PilZ domain; Region: PilZ; pfam07238 1271864006730 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1271864006731 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864006732 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864006733 catalytic residue [active] 1271864006734 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1271864006735 dimer interface [polypeptide binding]; other site 1271864006736 catalytic triad [active] 1271864006737 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1271864006738 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1271864006739 TrkA-C domain; Region: TrkA_C; pfam02080 1271864006740 Transporter associated domain; Region: CorC_HlyC; smart01091 1271864006741 alanine racemase; Reviewed; Region: dadX; PRK03646 1271864006742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1271864006743 active site 1271864006744 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1271864006745 substrate binding site [chemical binding]; other site 1271864006746 catalytic residues [active] 1271864006747 dimer interface [polypeptide binding]; other site 1271864006748 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1271864006749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1271864006750 SpoVR family protein; Provisional; Region: PRK11767 1271864006751 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1271864006752 fatty acid metabolism regulator; Provisional; Region: PRK04984 1271864006753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864006754 DNA-binding site [nucleotide binding]; DNA binding site 1271864006755 FadR C-terminal domain; Region: FadR_C; pfam07840 1271864006756 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1271864006757 transmembrane helices; other site 1271864006758 disulfide bond formation protein B; Provisional; Region: PRK01749 1271864006759 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1271864006760 GnsA/GnsB family; Region: GnsAB; pfam08178 1271864006761 hypothetical protein; Provisional; Region: PRK05170 1271864006762 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1271864006763 hypothetical protein; Provisional; Region: PRK10691 1271864006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1271864006765 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1271864006766 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1271864006767 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1271864006768 cell division inhibitor MinD; Provisional; Region: PRK10818 1271864006769 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1271864006770 Switch I; other site 1271864006771 Switch II; other site 1271864006772 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1271864006773 ribonuclease D; Provisional; Region: PRK10829 1271864006774 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1271864006775 catalytic site [active] 1271864006776 putative active site [active] 1271864006777 putative substrate binding site [chemical binding]; other site 1271864006778 HRDC domain; Region: HRDC; cl02578 1271864006779 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1271864006780 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1271864006781 acyl-activating enzyme (AAE) consensus motif; other site 1271864006782 putative AMP binding site [chemical binding]; other site 1271864006783 putative active site [active] 1271864006784 putative CoA binding site [chemical binding]; other site 1271864006785 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1271864006786 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1271864006787 Glycoprotease family; Region: Peptidase_M22; pfam00814 1271864006788 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1271864006789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1271864006790 DEAD_2; Region: DEAD_2; pfam06733 1271864006791 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1271864006792 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1271864006793 homotrimer interaction site [polypeptide binding]; other site 1271864006794 putative active site [active] 1271864006795 hypothetical protein; Provisional; Region: PRK05114 1271864006796 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1271864006797 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1271864006798 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1271864006799 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1271864006800 putative active site [active] 1271864006801 putative CoA binding site [chemical binding]; other site 1271864006802 nudix motif; other site 1271864006803 metal binding site [ion binding]; metal-binding site 1271864006804 L-serine deaminase; Provisional; Region: PRK15023 1271864006805 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1271864006806 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1271864006807 phage resistance protein; Provisional; Region: PRK10551 1271864006808 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1271864006809 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864006810 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1271864006811 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1271864006812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1271864006813 Transporter associated domain; Region: CorC_HlyC; smart01091 1271864006814 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1271864006815 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1271864006816 active pocket/dimerization site; other site 1271864006817 active site 1271864006818 phosphorylation site [posttranslational modification] 1271864006819 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1271864006820 active site 1271864006821 phosphorylation site [posttranslational modification] 1271864006822 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1271864006823 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1271864006824 hypothetical protein; Provisional; Region: PRK02913 1271864006825 hypothetical protein; Provisional; Region: PRK11469 1271864006826 Domain of unknown function DUF; Region: DUF204; pfam02659 1271864006827 Domain of unknown function DUF; Region: DUF204; pfam02659 1271864006828 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1271864006829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864006830 S-adenosylmethionine binding site [chemical binding]; other site 1271864006831 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1271864006832 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1271864006833 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1271864006834 cspA; Derived by automated computational analysis using gene prediction method: cmsearch. 1271864006835 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1271864006836 DNA-binding site [nucleotide binding]; DNA binding site 1271864006837 RNA-binding motif; other site 1271864006838 YebO-like protein; Region: YebO; pfam13974 1271864006839 PhoPQ regulatory protein; Provisional; Region: PRK10299 1271864006840 YobH-like protein; Region: YobH; pfam13996 1271864006841 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1271864006842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864006843 dimerization interface [polypeptide binding]; other site 1271864006844 putative Zn2+ binding site [ion binding]; other site 1271864006845 putative DNA binding site [nucleotide binding]; other site 1271864006846 Bacterial transcriptional regulator; Region: IclR; pfam01614 1271864006847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864006848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864006849 putative substrate translocation pore; other site 1271864006850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864006851 heat shock protein HtpX; Provisional; Region: PRK05457 1271864006852 carboxy-terminal protease; Provisional; Region: PRK11186 1271864006853 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1271864006854 protein binding site [polypeptide binding]; other site 1271864006855 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1271864006856 Catalytic dyad [active] 1271864006857 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1271864006858 ProP expression regulator; Provisional; Region: PRK04950 1271864006859 ProQ/FINO family; Region: ProQ; pfam04352 1271864006860 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1271864006861 GAF domain; Region: GAF_2; pfam13185 1271864006862 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1271864006863 Paraquat-inducible protein A; Region: PqiA; pfam04403 1271864006864 Paraquat-inducible protein A; Region: PqiA; pfam04403 1271864006865 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1271864006866 mce related protein; Region: MCE; pfam02470 1271864006867 mce related protein; Region: MCE; pfam02470 1271864006868 mce related protein; Region: MCE; pfam02470 1271864006869 mce related protein; Region: MCE; pfam02470 1271864006870 mce related protein; Region: MCE; pfam02470 1271864006871 mce related protein; Region: MCE; pfam02470 1271864006872 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1271864006873 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1271864006874 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1271864006875 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1271864006876 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1271864006877 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1271864006878 type III secretion protein SopE2; Provisional; Region: PRK15280 1271864006879 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 1271864006880 SopE GEF domain; Region: SopE_GEF; pfam07487 1271864006881 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1271864006882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864006883 Coenzyme A binding pocket [chemical binding]; other site 1271864006884 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1271864006885 DNA binding site [nucleotide binding] 1271864006886 active site 1271864006887 Int/Topo IB signature motif; other site 1271864006888 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1271864006889 EamA-like transporter family; Region: EamA; pfam00892 1271864006890 EamA-like transporter family; Region: EamA; pfam00892 1271864006891 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1271864006892 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1271864006893 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1271864006894 exonuclease VIII; Reviewed; Region: PRK09709 1271864006895 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1271864006896 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1271864006897 dimer interface [polypeptide binding]; other site 1271864006898 active site 1271864006899 Int/Topo IB signature motif; other site 1271864006900 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1271864006901 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1271864006902 hypothetical protein; Provisional; Region: PRK10301 1271864006903 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1271864006904 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1271864006905 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1271864006906 exodeoxyribonuclease X; Provisional; Region: PRK07983 1271864006907 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1271864006908 active site 1271864006909 catalytic site [active] 1271864006910 substrate binding site [chemical binding]; other site 1271864006911 protease 2; Provisional; Region: PRK10115 1271864006912 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1271864006913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1271864006914 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1271864006915 putative metal binding site [ion binding]; other site 1271864006916 hypothetical protein; Provisional; Region: PRK13680 1271864006917 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1271864006918 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1271864006919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1271864006920 ATP-grasp domain; Region: ATP-grasp; pfam02222 1271864006921 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1271864006922 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1271864006923 active site 1271864006924 intersubunit interface [polypeptide binding]; other site 1271864006925 catalytic residue [active] 1271864006926 phosphogluconate dehydratase; Validated; Region: PRK09054 1271864006927 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1271864006928 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1271864006929 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1271864006930 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1271864006931 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1271864006932 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1271864006933 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1271864006934 putative active site [active] 1271864006935 pyruvate kinase; Provisional; Region: PRK05826 1271864006936 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1271864006937 domain interfaces; other site 1271864006938 active site 1271864006939 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1271864006940 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1271864006941 putative acyl-acceptor binding pocket; other site 1271864006942 putative peptidase; Provisional; Region: PRK11649 1271864006943 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1271864006944 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864006945 Peptidase family M23; Region: Peptidase_M23; pfam01551 1271864006946 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1271864006947 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1271864006948 metal binding site [ion binding]; metal-binding site 1271864006949 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1271864006950 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1271864006951 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1271864006952 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864006953 ABC-ATPase subunit interface; other site 1271864006954 dimer interface [polypeptide binding]; other site 1271864006955 putative PBP binding regions; other site 1271864006956 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1271864006957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864006958 Walker A motif; other site 1271864006959 ATP binding site [chemical binding]; other site 1271864006960 Walker B motif; other site 1271864006961 arginine finger; other site 1271864006962 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1271864006963 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1271864006964 RuvA N terminal domain; Region: RuvA_N; pfam01330 1271864006965 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1271864006966 hypothetical protein; Provisional; Region: PRK11470 1271864006967 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1271864006968 active site 1271864006969 putative DNA-binding cleft [nucleotide binding]; other site 1271864006970 dimer interface [polypeptide binding]; other site 1271864006971 hypothetical protein; Validated; Region: PRK00110 1271864006972 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1271864006973 nudix motif; other site 1271864006974 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1271864006975 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1271864006976 dimer interface [polypeptide binding]; other site 1271864006977 anticodon binding site; other site 1271864006978 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1271864006979 homodimer interface [polypeptide binding]; other site 1271864006980 motif 1; other site 1271864006981 active site 1271864006982 motif 2; other site 1271864006983 GAD domain; Region: GAD; pfam02938 1271864006984 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1271864006985 active site 1271864006986 motif 3; other site 1271864006987 Isochorismatase family; Region: Isochorismatase; pfam00857 1271864006988 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1271864006989 catalytic triad [active] 1271864006990 conserved cis-peptide bond; other site 1271864006991 hypothetical protein; Provisional; Region: PRK10302 1271864006992 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1271864006993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864006994 S-adenosylmethionine binding site [chemical binding]; other site 1271864006995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864006996 S-adenosylmethionine binding site [chemical binding]; other site 1271864006997 copper homeostasis protein CutC; Provisional; Region: PRK11572 1271864006998 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1271864006999 putative metal binding site [ion binding]; other site 1271864007000 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1271864007001 arginyl-tRNA synthetase; Region: argS; TIGR00456 1271864007002 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1271864007003 active site 1271864007004 HIGH motif; other site 1271864007005 KMSK motif region; other site 1271864007006 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1271864007007 tRNA binding surface [nucleotide binding]; other site 1271864007008 anticodon binding site; other site 1271864007009 penicillin-binding protein 2; Provisional; Region: PRK10795 1271864007010 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1271864007011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1271864007012 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1271864007013 Flagellar protein FlhE; Region: FlhE; pfam06366 1271864007014 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1271864007015 FHIPEP family; Region: FHIPEP; pfam00771 1271864007016 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1271864007017 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1271864007018 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1271864007019 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1271864007020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864007021 active site 1271864007022 phosphorylation site [posttranslational modification] 1271864007023 intermolecular recognition site; other site 1271864007024 dimerization interface [polypeptide binding]; other site 1271864007025 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1271864007026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864007027 active site 1271864007028 phosphorylation site [posttranslational modification] 1271864007029 intermolecular recognition site; other site 1271864007030 dimerization interface [polypeptide binding]; other site 1271864007031 CheB methylesterase; Region: CheB_methylest; pfam01339 1271864007032 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1271864007033 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1271864007034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864007035 S-adenosylmethionine binding site [chemical binding]; other site 1271864007036 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1271864007037 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1271864007038 dimer interface [polypeptide binding]; other site 1271864007039 ligand binding site [chemical binding]; other site 1271864007040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864007041 dimerization interface [polypeptide binding]; other site 1271864007042 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864007043 dimer interface [polypeptide binding]; other site 1271864007044 putative CheW interface [polypeptide binding]; other site 1271864007045 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1271864007046 putative CheA interaction surface; other site 1271864007047 chemotaxis protein CheA; Provisional; Region: PRK10547 1271864007048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1271864007049 putative binding surface; other site 1271864007050 active site 1271864007051 CheY binding; Region: CheY-binding; pfam09078 1271864007052 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1271864007053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864007054 ATP binding site [chemical binding]; other site 1271864007055 Mg2+ binding site [ion binding]; other site 1271864007056 G-X-G motif; other site 1271864007057 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1271864007058 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1271864007059 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1271864007060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1271864007061 ligand binding site [chemical binding]; other site 1271864007062 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1271864007063 flagellar motor protein MotA; Validated; Region: PRK09110 1271864007064 transcriptional activator FlhC; Provisional; Region: PRK12722 1271864007065 transcriptional activator FlhD; Provisional; Region: PRK02909 1271864007066 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1271864007067 Ligand Binding Site [chemical binding]; other site 1271864007068 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1271864007069 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1271864007070 active site 1271864007071 homotetramer interface [polypeptide binding]; other site 1271864007072 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1271864007073 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1271864007074 DJ-1 family protein; Region: not_thiJ; TIGR01383 1271864007075 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1271864007076 conserved cys residue [active] 1271864007077 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1271864007078 Ferritin-like domain; Region: Ferritin; pfam00210 1271864007079 ferroxidase diiron center [ion binding]; other site 1271864007080 hypothetical protein; Provisional; Region: PRK09273 1271864007081 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1271864007082 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1271864007083 YecR-like lipoprotein; Region: YecR; pfam13992 1271864007084 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1271864007085 Ferritin-like domain; Region: Ferritin; pfam00210 1271864007086 ferroxidase diiron center [ion binding]; other site 1271864007087 probable metal-binding protein; Region: matur_matur; TIGR03853 1271864007088 tyrosine transporter TyrP; Provisional; Region: PRK15132 1271864007089 aromatic amino acid transport protein; Region: araaP; TIGR00837 1271864007090 hypothetical protein; Provisional; Region: PRK10396 1271864007091 yecA family protein; Region: ygfB_yecA; TIGR02292 1271864007092 SEC-C motif; Region: SEC-C; pfam02810 1271864007093 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 1271864007094 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1271864007095 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 1271864007096 NlpC/P60 family; Region: NLPC_P60; cl17555 1271864007097 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1271864007098 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1271864007099 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1271864007100 GIY-YIG motif/motif A; other site 1271864007101 active site 1271864007102 catalytic site [active] 1271864007103 putative DNA binding site [nucleotide binding]; other site 1271864007104 metal binding site [ion binding]; metal-binding site 1271864007105 UvrB/uvrC motif; Region: UVR; pfam02151 1271864007106 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1271864007107 Helix-hairpin-helix motif; Region: HHH; pfam00633 1271864007108 response regulator; Provisional; Region: PRK09483 1271864007109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864007110 active site 1271864007111 phosphorylation site [posttranslational modification] 1271864007112 intermolecular recognition site; other site 1271864007113 dimerization interface [polypeptide binding]; other site 1271864007114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864007115 DNA binding residues [nucleotide binding] 1271864007116 dimerization interface [polypeptide binding]; other site 1271864007117 hypothetical protein; Provisional; Region: PRK10613 1271864007118 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1271864007119 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1271864007120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864007121 DNA binding residues [nucleotide binding] 1271864007122 dimerization interface [polypeptide binding]; other site 1271864007123 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1271864007124 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1271864007125 Walker A/P-loop; other site 1271864007126 ATP binding site [chemical binding]; other site 1271864007127 Q-loop/lid; other site 1271864007128 ABC transporter signature motif; other site 1271864007129 Walker B; other site 1271864007130 D-loop; other site 1271864007131 H-loop/switch region; other site 1271864007132 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1271864007133 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864007134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864007135 dimer interface [polypeptide binding]; other site 1271864007136 conserved gate region; other site 1271864007137 putative PBP binding loops; other site 1271864007138 ABC-ATPase subunit interface; other site 1271864007139 D-cysteine desulfhydrase; Validated; Region: PRK03910 1271864007140 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1271864007141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864007142 catalytic residue [active] 1271864007143 cystine transporter subunit; Provisional; Region: PRK11260 1271864007144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864007145 substrate binding pocket [chemical binding]; other site 1271864007146 membrane-bound complex binding site; other site 1271864007147 hinge residues; other site 1271864007148 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1271864007149 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1271864007150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1271864007151 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1271864007152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1271864007153 DNA binding residues [nucleotide binding] 1271864007154 flagellin; Validated; Region: PRK08026 1271864007155 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1271864007156 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1271864007157 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1271864007158 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1271864007159 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1271864007160 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1271864007161 flagellar protein FliS; Validated; Region: fliS; PRK05685 1271864007162 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1271864007163 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1271864007164 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1271864007165 active site 1271864007166 Na/Ca binding site [ion binding]; other site 1271864007167 catalytic site [active] 1271864007168 lipoprotein; Provisional; Region: PRK10397 1271864007169 putative inner membrane protein; Provisional; Region: PRK11099 1271864007170 Sulphur transport; Region: Sulf_transp; pfam04143 1271864007171 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1271864007172 CPxP motif; other site 1271864007173 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1271864007174 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1271864007175 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1271864007176 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1271864007177 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1271864007178 FliG C-terminal domain; Region: FliG_C; pfam01706 1271864007179 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1271864007180 Flagellar assembly protein FliH; Region: FliH; pfam02108 1271864007181 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1271864007182 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1271864007183 Walker A motif/ATP binding site; other site 1271864007184 Walker B motif; other site 1271864007185 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1271864007186 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1271864007187 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1271864007188 flagellar hook-length control protein; Provisional; Region: PRK10118 1271864007189 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1271864007190 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1271864007191 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1271864007192 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1271864007193 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1271864007194 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1271864007195 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1271864007196 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1271864007197 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1271864007198 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1271864007199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864007200 DNA binding residues [nucleotide binding] 1271864007201 dimerization interface [polypeptide binding]; other site 1271864007202 hypothetical protein; Provisional; Region: PRK10708 1271864007203 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1271864007204 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1271864007205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864007206 active site 1271864007207 motif I; other site 1271864007208 motif II; other site 1271864007209 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1271864007210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864007211 metal binding site [ion binding]; metal-binding site 1271864007212 active site 1271864007213 I-site; other site 1271864007214 Uncharacterized small protein [Function unknown]; Region: COG5475 1271864007215 hypothetical protein; Provisional; Region: PRK10062 1271864007216 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1271864007217 EamA-like transporter family; Region: EamA; pfam00892 1271864007218 EamA-like transporter family; Region: EamA; pfam00892 1271864007219 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1271864007220 additional DNA contacts [nucleotide binding]; other site 1271864007221 mismatch recognition site; other site 1271864007222 active site 1271864007223 zinc binding site [ion binding]; other site 1271864007224 DNA intercalation site [nucleotide binding]; other site 1271864007225 DNA cytosine methylase; Provisional; Region: PRK10458 1271864007226 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1271864007227 cofactor binding site; other site 1271864007228 DNA binding site [nucleotide binding] 1271864007229 substrate interaction site [chemical binding]; other site 1271864007230 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1271864007231 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1271864007232 Zn2+ binding site [ion binding]; other site 1271864007233 Mg2+ binding site [ion binding]; other site 1271864007234 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864007235 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1271864007236 trimer interface [polypeptide binding]; other site 1271864007237 eyelet of channel; other site 1271864007238 cspA; Derived by automated computational analysis using gene prediction method: cmsearch. 1271864007239 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1271864007240 DNA-binding site [nucleotide binding]; DNA binding site 1271864007241 RNA-binding motif; other site 1271864007242 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1271864007243 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1271864007244 active site 1271864007245 DNA binding site [nucleotide binding] 1271864007246 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1271864007247 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1271864007248 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1271864007249 Catalytic site [active] 1271864007250 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1271864007251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1271864007252 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1271864007253 putative protease; Region: PHA00666 1271864007254 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1271864007255 Integrase; Region: Integrase_1; pfam12835 1271864007256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1271864007257 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864007258 Sel1 repeat; Region: Sel1; pfam08238 1271864007259 Sel1-like repeats; Region: SEL1; smart00671 1271864007260 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1271864007261 AMP nucleosidase; Provisional; Region: PRK08292 1271864007262 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1271864007263 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1271864007264 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1271864007265 MATE family multidrug exporter; Provisional; Region: PRK10189 1271864007266 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1271864007267 L,D-transpeptidase; Provisional; Region: PRK10190 1271864007268 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1271864007269 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1271864007270 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1271864007271 putative dimer interface [polypeptide binding]; other site 1271864007272 active site pocket [active] 1271864007273 putative cataytic base [active] 1271864007274 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1271864007275 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1271864007276 homotrimer interface [polypeptide binding]; other site 1271864007277 Walker A motif; other site 1271864007278 GTP binding site [chemical binding]; other site 1271864007279 Walker B motif; other site 1271864007280 cobyric acid synthase; Provisional; Region: PRK00784 1271864007281 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1271864007282 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1271864007283 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1271864007284 catalytic triad [active] 1271864007285 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1271864007286 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1271864007287 Walker A/P-loop; other site 1271864007288 ATP binding site [chemical binding]; other site 1271864007289 Q-loop/lid; other site 1271864007290 ABC transporter signature motif; other site 1271864007291 Walker B; other site 1271864007292 D-loop; other site 1271864007293 H-loop/switch region; other site 1271864007294 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1271864007295 cobalt transport protein CbiN; Provisional; Region: PRK02898 1271864007296 cobalt transport protein CbiM; Validated; Region: PRK08319 1271864007297 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1271864007298 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1271864007299 active site 1271864007300 SAM binding site [chemical binding]; other site 1271864007301 homodimer interface [polypeptide binding]; other site 1271864007302 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1271864007303 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1271864007304 active site 1271864007305 C-terminal domain interface [polypeptide binding]; other site 1271864007306 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1271864007307 active site 1271864007308 N-terminal domain interface [polypeptide binding]; other site 1271864007309 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1271864007310 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1271864007311 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1271864007312 active site 1271864007313 SAM binding site [chemical binding]; other site 1271864007314 homodimer interface [polypeptide binding]; other site 1271864007315 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1271864007316 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1271864007317 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1271864007318 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1271864007319 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1271864007320 active site 1271864007321 SAM binding site [chemical binding]; other site 1271864007322 homodimer interface [polypeptide binding]; other site 1271864007323 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1271864007324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864007325 S-adenosylmethionine binding site [chemical binding]; other site 1271864007326 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1271864007327 active site 1271864007328 putative homodimer interface [polypeptide binding]; other site 1271864007329 SAM binding site [chemical binding]; other site 1271864007330 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1271864007331 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1271864007332 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1271864007333 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1271864007334 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1271864007335 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1271864007336 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1271864007337 catalytic triad [active] 1271864007338 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1271864007339 Sensory domain found in PocR; Region: PocR; pfam10114 1271864007340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864007341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864007342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864007343 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1271864007344 amphipathic channel; other site 1271864007345 Asn-Pro-Ala signature motifs; other site 1271864007346 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1271864007347 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1271864007348 Hexamer interface [polypeptide binding]; other site 1271864007349 Putative hexagonal pore residue; other site 1271864007350 propanediol utilization protein PduB; Provisional; Region: PRK15415 1271864007351 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1271864007352 putative hexamer interface [polypeptide binding]; other site 1271864007353 putative hexagonal pore; other site 1271864007354 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1271864007355 putative hexamer interface [polypeptide binding]; other site 1271864007356 putative hexagonal pore; other site 1271864007357 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1271864007358 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1271864007359 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1271864007360 alpha-beta subunit interface [polypeptide binding]; other site 1271864007361 alpha-gamma subunit interface [polypeptide binding]; other site 1271864007362 active site 1271864007363 substrate and K+ binding site; other site 1271864007364 K+ binding site [ion binding]; other site 1271864007365 cobalamin binding site [chemical binding]; other site 1271864007366 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1271864007367 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1271864007368 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1271864007369 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1271864007370 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1271864007371 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1271864007372 Hexamer interface [polypeptide binding]; other site 1271864007373 Putative hexagonal pore residue; other site 1271864007374 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1271864007375 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1271864007376 putative hexamer interface [polypeptide binding]; other site 1271864007377 putative hexagonal pore; other site 1271864007378 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1271864007379 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1271864007380 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1271864007381 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1271864007382 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1271864007383 Hexamer/Pentamer interface [polypeptide binding]; other site 1271864007384 central pore; other site 1271864007385 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1271864007386 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1271864007387 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1271864007388 putative catalytic cysteine [active] 1271864007389 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1271864007390 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1271864007391 putative active site [active] 1271864007392 metal binding site [ion binding]; metal-binding site 1271864007393 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1271864007394 SLBB domain; Region: SLBB; pfam10531 1271864007395 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1271864007396 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1271864007397 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1271864007398 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1271864007399 putative hexamer interface [polypeptide binding]; other site 1271864007400 putative hexagonal pore; other site 1271864007401 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1271864007402 putative hexamer interface [polypeptide binding]; other site 1271864007403 putative hexagonal pore; other site 1271864007404 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1271864007405 putative hexamer interface [polypeptide binding]; other site 1271864007406 putative hexagonal pore; other site 1271864007407 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 1271864007408 G3 box; other site 1271864007409 Switch II region; other site 1271864007410 GTP/Mg2+ binding site [chemical binding]; other site 1271864007411 G4 box; other site 1271864007412 G5 box; other site 1271864007413 propionate kinase; Reviewed; Region: PRK12397 1271864007414 propionate/acetate kinase; Provisional; Region: PRK12379 1271864007415 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1271864007416 hypothetical protein; Provisional; Region: PRK05423 1271864007417 Predicted membrane protein [Function unknown]; Region: COG1289 1271864007418 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1271864007419 DNA gyrase inhibitor; Provisional; Region: PRK10016 1271864007420 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1271864007421 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1271864007422 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1271864007423 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1271864007424 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1271864007425 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1271864007426 4Fe-4S binding domain; Region: Fer4; cl02805 1271864007427 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1271864007428 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1271864007429 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1271864007430 putative [Fe4-S4] binding site [ion binding]; other site 1271864007431 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864007432 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864007433 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1271864007434 putative molybdopterin cofactor binding site; other site 1271864007435 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 1271864007436 SopA-like central domain; Region: SopA; pfam13981 1271864007437 SopA-like catalytic domain; Region: SopA_C; pfam13979 1271864007438 exonuclease I; Provisional; Region: sbcB; PRK11779 1271864007439 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1271864007440 active site 1271864007441 catalytic site [active] 1271864007442 substrate binding site [chemical binding]; other site 1271864007443 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1271864007444 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1271864007445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864007446 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1271864007447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864007448 dimerization interface [polypeptide binding]; other site 1271864007449 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1271864007450 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1271864007451 putative NAD(P) binding site [chemical binding]; other site 1271864007452 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1271864007453 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1271864007454 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1271864007455 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1271864007456 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1271864007457 NAD binding site [chemical binding]; other site 1271864007458 dimerization interface [polypeptide binding]; other site 1271864007459 product binding site; other site 1271864007460 substrate binding site [chemical binding]; other site 1271864007461 zinc binding site [ion binding]; other site 1271864007462 catalytic residues [active] 1271864007463 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1271864007464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864007465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864007466 homodimer interface [polypeptide binding]; other site 1271864007467 catalytic residue [active] 1271864007468 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1271864007469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864007470 active site 1271864007471 motif I; other site 1271864007472 motif II; other site 1271864007473 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1271864007474 putative active site pocket [active] 1271864007475 4-fold oligomerization interface [polypeptide binding]; other site 1271864007476 metal binding residues [ion binding]; metal-binding site 1271864007477 3-fold/trimer interface [polypeptide binding]; other site 1271864007478 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1271864007479 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1271864007480 putative active site [active] 1271864007481 oxyanion strand; other site 1271864007482 catalytic triad [active] 1271864007483 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1271864007484 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1271864007485 catalytic residues [active] 1271864007486 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1271864007487 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1271864007488 substrate binding site [chemical binding]; other site 1271864007489 glutamase interaction surface [polypeptide binding]; other site 1271864007490 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1271864007491 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1271864007492 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1271864007493 metal binding site [ion binding]; metal-binding site 1271864007494 chain length determinant protein WzzB; Provisional; Region: PRK15471 1271864007495 Chain length determinant protein; Region: Wzz; pfam02706 1271864007496 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1271864007497 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1271864007498 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1271864007499 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1271864007500 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1271864007501 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1271864007502 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1271864007503 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1271864007504 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1271864007505 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1271864007506 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1271864007507 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1271864007508 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1271864007509 active site 1271864007510 substrate binding site [chemical binding]; other site 1271864007511 metal binding site [ion binding]; metal-binding site 1271864007512 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1271864007513 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1271864007514 Substrate binding site; other site 1271864007515 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1271864007516 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1271864007517 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1271864007518 active site 1271864007519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864007520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1271864007521 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1271864007522 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1271864007523 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1271864007524 active site 1271864007525 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1271864007526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1271864007527 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1271864007528 NAD(P) binding site [chemical binding]; other site 1271864007529 active site 1271864007530 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1271864007531 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1271864007532 inhibitor-cofactor binding pocket; inhibition site 1271864007533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864007534 catalytic residue [active] 1271864007535 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1271864007536 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1271864007537 NAD binding site [chemical binding]; other site 1271864007538 homotetramer interface [polypeptide binding]; other site 1271864007539 homodimer interface [polypeptide binding]; other site 1271864007540 substrate binding site [chemical binding]; other site 1271864007541 active site 1271864007542 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1271864007543 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1271864007544 substrate binding site; other site 1271864007545 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1271864007546 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1271864007547 catalytic loop [active] 1271864007548 iron binding site [ion binding]; other site 1271864007549 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1271864007550 FAD binding pocket [chemical binding]; other site 1271864007551 FAD binding motif [chemical binding]; other site 1271864007552 phosphate binding motif [ion binding]; other site 1271864007553 beta-alpha-beta structure motif; other site 1271864007554 NAD binding pocket [chemical binding]; other site 1271864007555 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1271864007556 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 1271864007557 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1271864007558 substrate binding site; other site 1271864007559 tetramer interface; other site 1271864007560 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1271864007561 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1271864007562 NADP binding site [chemical binding]; other site 1271864007563 active site 1271864007564 putative substrate binding site [chemical binding]; other site 1271864007565 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1271864007566 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1271864007567 NAD binding site [chemical binding]; other site 1271864007568 substrate binding site [chemical binding]; other site 1271864007569 homodimer interface [polypeptide binding]; other site 1271864007570 active site 1271864007571 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1271864007572 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1271864007573 active site 1271864007574 tetramer interface; other site 1271864007575 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 1271864007576 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1271864007577 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1271864007578 putative ADP-binding pocket [chemical binding]; other site 1271864007579 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1271864007580 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1271864007581 colanic acid exporter; Provisional; Region: PRK10459 1271864007582 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1271864007583 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1271864007584 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1271864007585 phosphomannomutase CpsG; Provisional; Region: PRK15414 1271864007586 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1271864007587 active site 1271864007588 substrate binding site [chemical binding]; other site 1271864007589 metal binding site [ion binding]; metal-binding site 1271864007590 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1271864007591 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1271864007592 Substrate binding site; other site 1271864007593 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1271864007594 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1271864007595 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1271864007596 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1271864007597 active site 1271864007598 GDP-Mannose binding site [chemical binding]; other site 1271864007599 dimer interface [polypeptide binding]; other site 1271864007600 modified nudix motif 1271864007601 metal binding site [ion binding]; metal-binding site 1271864007602 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1271864007603 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1271864007604 NADP binding site [chemical binding]; other site 1271864007605 active site 1271864007606 putative substrate binding site [chemical binding]; other site 1271864007607 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1271864007608 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1271864007609 NADP-binding site; other site 1271864007610 homotetramer interface [polypeptide binding]; other site 1271864007611 substrate binding site [chemical binding]; other site 1271864007612 homodimer interface [polypeptide binding]; other site 1271864007613 active site 1271864007614 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1271864007615 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1271864007616 putative trimer interface [polypeptide binding]; other site 1271864007617 putative active site [active] 1271864007618 putative substrate binding site [chemical binding]; other site 1271864007619 putative CoA binding site [chemical binding]; other site 1271864007620 putative glycosyl transferase; Provisional; Region: PRK10063 1271864007621 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1271864007622 metal-binding site 1271864007623 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1271864007624 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1271864007625 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1271864007626 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1271864007627 putative acyl transferase; Provisional; Region: PRK10191 1271864007628 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1271864007629 trimer interface [polypeptide binding]; other site 1271864007630 active site 1271864007631 substrate binding site [chemical binding]; other site 1271864007632 CoA binding site [chemical binding]; other site 1271864007633 putative glycosyl transferase; Provisional; Region: PRK10018 1271864007634 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1271864007635 active site 1271864007636 tyrosine kinase; Provisional; Region: PRK11519 1271864007637 Chain length determinant protein; Region: Wzz; pfam02706 1271864007638 Chain length determinant protein; Region: Wzz; cl15801 1271864007639 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1271864007640 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1271864007641 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1271864007642 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1271864007643 active site 1271864007644 polysaccharide export protein Wza; Provisional; Region: PRK15078 1271864007645 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1271864007646 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1271864007647 FOG: CBS domain [General function prediction only]; Region: COG0517 1271864007648 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1271864007649 Transporter associated domain; Region: CorC_HlyC; smart01091 1271864007650 putative assembly protein; Provisional; Region: PRK10833 1271864007651 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1271864007652 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1271864007653 trimer interface [polypeptide binding]; other site 1271864007654 active site 1271864007655 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1271864007656 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1271864007657 ATP-binding site [chemical binding]; other site 1271864007658 Sugar specificity; other site 1271864007659 Pyrimidine base specificity; other site 1271864007660 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1271864007661 PAS domain S-box; Region: sensory_box; TIGR00229 1271864007662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864007663 putative active site [active] 1271864007664 heme pocket [chemical binding]; other site 1271864007665 PAS domain S-box; Region: sensory_box; TIGR00229 1271864007666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864007667 putative active site [active] 1271864007668 heme pocket [chemical binding]; other site 1271864007669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1271864007670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864007671 metal binding site [ion binding]; metal-binding site 1271864007672 active site 1271864007673 I-site; other site 1271864007674 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864007675 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1271864007676 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1271864007677 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1271864007678 minor groove reading motif; other site 1271864007679 helix-hairpin-helix signature motif; other site 1271864007680 substrate binding pocket [chemical binding]; other site 1271864007681 active site 1271864007682 putative chaperone; Provisional; Region: PRK11678 1271864007683 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1271864007684 nucleotide binding site [chemical binding]; other site 1271864007685 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1271864007686 SBD interface [polypeptide binding]; other site 1271864007687 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1271864007688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864007689 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864007690 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1271864007691 Protein export membrane protein; Region: SecD_SecF; cl14618 1271864007692 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1271864007693 putative transporter; Provisional; Region: PRK10504 1271864007694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864007695 putative substrate translocation pore; other site 1271864007696 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1271864007697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864007698 dimerization interface [polypeptide binding]; other site 1271864007699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864007700 dimer interface [polypeptide binding]; other site 1271864007701 phosphorylation site [posttranslational modification] 1271864007702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864007703 ATP binding site [chemical binding]; other site 1271864007704 Mg2+ binding site [ion binding]; other site 1271864007705 G-X-G motif; other site 1271864007706 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1271864007707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864007708 active site 1271864007709 phosphorylation site [posttranslational modification] 1271864007710 intermolecular recognition site; other site 1271864007711 dimerization interface [polypeptide binding]; other site 1271864007712 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864007713 DNA binding site [nucleotide binding] 1271864007714 PcfJ-like protein; Region: PcfJ; pfam14284 1271864007715 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1271864007716 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 1271864007717 putative protease; Provisional; Region: PRK15452 1271864007718 Peptidase family U32; Region: Peptidase_U32; pfam01136 1271864007719 type III secretion system protein; Provisional; Region: PRK15383 1271864007720 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 1271864007721 lipid kinase; Reviewed; Region: PRK13054 1271864007722 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1271864007723 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1271864007724 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1271864007725 putative active site; other site 1271864007726 catalytic residue [active] 1271864007727 nucleoside transporter; Region: 2A0110; TIGR00889 1271864007728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864007729 putative substrate translocation pore; other site 1271864007730 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1271864007731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864007732 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1271864007733 substrate binding site [chemical binding]; other site 1271864007734 ATP binding site [chemical binding]; other site 1271864007735 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1271864007736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864007737 DNA-binding site [nucleotide binding]; DNA binding site 1271864007738 UTRA domain; Region: UTRA; pfam07702 1271864007739 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1271864007740 dimer interface [polypeptide binding]; other site 1271864007741 substrate binding site [chemical binding]; other site 1271864007742 ATP binding site [chemical binding]; other site 1271864007743 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1271864007744 substrate binding site [chemical binding]; other site 1271864007745 multimerization interface [polypeptide binding]; other site 1271864007746 ATP binding site [chemical binding]; other site 1271864007747 Predicted integral membrane protein [Function unknown]; Region: COG5455 1271864007748 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1271864007749 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1271864007750 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1271864007751 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864007752 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864007753 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864007754 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 1271864007755 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864007756 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864007757 fimbrial chaperone protein; Provisional; Region: PRK15220 1271864007758 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1271864007759 antiporter inner membrane protein; Provisional; Region: PRK11670 1271864007760 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1271864007761 Walker A motif; other site 1271864007762 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1271864007763 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1271864007764 active site 1271864007765 HIGH motif; other site 1271864007766 KMSKS motif; other site 1271864007767 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1271864007768 tRNA binding surface [nucleotide binding]; other site 1271864007769 anticodon binding site; other site 1271864007770 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1271864007771 dimer interface [polypeptide binding]; other site 1271864007772 putative tRNA-binding site [nucleotide binding]; other site 1271864007773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1271864007774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1271864007775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1271864007776 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1271864007777 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1271864007778 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1271864007779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864007780 active site 1271864007781 phosphorylation site [posttranslational modification] 1271864007782 intermolecular recognition site; other site 1271864007783 dimerization interface [polypeptide binding]; other site 1271864007784 LytTr DNA-binding domain; Region: LytTR; pfam04397 1271864007785 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1271864007786 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1271864007787 GAF domain; Region: GAF; pfam01590 1271864007788 Histidine kinase; Region: His_kinase; pfam06580 1271864007789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864007790 ATP binding site [chemical binding]; other site 1271864007791 Mg2+ binding site [ion binding]; other site 1271864007792 G-X-G motif; other site 1271864007793 transcriptional regulator MirA; Provisional; Region: PRK15043 1271864007794 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1271864007795 DNA binding residues [nucleotide binding] 1271864007796 hypothetical protein; Provisional; Region: PRK13681 1271864007797 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1271864007798 putative PBP binding loops; other site 1271864007799 ABC-ATPase subunit interface; other site 1271864007800 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1271864007801 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1271864007802 Walker A/P-loop; other site 1271864007803 ATP binding site [chemical binding]; other site 1271864007804 Q-loop/lid; other site 1271864007805 ABC transporter signature motif; other site 1271864007806 Walker B; other site 1271864007807 D-loop; other site 1271864007808 H-loop/switch region; other site 1271864007809 CBS domain; Region: CBS; pfam00571 1271864007810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864007811 dimer interface [polypeptide binding]; other site 1271864007812 conserved gate region; other site 1271864007813 ABC-ATPase subunit interface; other site 1271864007814 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1271864007815 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1271864007816 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1271864007817 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1271864007818 D-lactate dehydrogenase; Provisional; Region: PRK11183 1271864007819 FAD binding domain; Region: FAD_binding_4; pfam01565 1271864007820 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1271864007821 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1271864007822 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1271864007823 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1271864007824 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1271864007825 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1271864007826 oxidoreductase; Provisional; Region: PRK12743 1271864007827 classical (c) SDRs; Region: SDR_c; cd05233 1271864007828 NAD(P) binding site [chemical binding]; other site 1271864007829 active site 1271864007830 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1271864007831 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1271864007832 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1271864007833 FMN binding site [chemical binding]; other site 1271864007834 active site 1271864007835 catalytic residues [active] 1271864007836 substrate binding site [chemical binding]; other site 1271864007837 salicylate hydroxylase; Provisional; Region: PRK08163 1271864007838 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1271864007839 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1271864007840 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1271864007841 C-terminal domain interface [polypeptide binding]; other site 1271864007842 GSH binding site (G-site) [chemical binding]; other site 1271864007843 putative dimer interface [polypeptide binding]; other site 1271864007844 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1271864007845 dimer interface [polypeptide binding]; other site 1271864007846 N-terminal domain interface [polypeptide binding]; other site 1271864007847 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1271864007848 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1271864007849 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1271864007850 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1271864007851 Cupin domain; Region: Cupin_2; pfam07883 1271864007852 Cupin domain; Region: Cupin_2; pfam07883 1271864007853 benzoate transport; Region: 2A0115; TIGR00895 1271864007854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864007855 putative substrate translocation pore; other site 1271864007856 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1271864007857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864007858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864007859 dimerization interface [polypeptide binding]; other site 1271864007860 hypothetical protein; Provisional; Region: PRK01821 1271864007861 hypothetical protein; Provisional; Region: PRK10711 1271864007862 cytidine deaminase; Provisional; Region: PRK09027 1271864007863 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1271864007864 active site 1271864007865 catalytic motif [active] 1271864007866 Zn binding site [ion binding]; other site 1271864007867 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1271864007868 active site 1271864007869 catalytic motif [active] 1271864007870 Zn binding site [ion binding]; other site 1271864007871 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1271864007872 putative active site [active] 1271864007873 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1271864007874 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1271864007875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1271864007876 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864007877 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1271864007878 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1271864007879 homodimer interface [polypeptide binding]; other site 1271864007880 active site 1271864007881 FMN binding site [chemical binding]; other site 1271864007882 substrate binding site [chemical binding]; other site 1271864007883 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1271864007884 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1271864007885 TM-ABC transporter signature motif; other site 1271864007886 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1271864007887 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1271864007888 Walker A/P-loop; other site 1271864007889 ATP binding site [chemical binding]; other site 1271864007890 Q-loop/lid; other site 1271864007891 ABC transporter signature motif; other site 1271864007892 Walker B; other site 1271864007893 D-loop; other site 1271864007894 H-loop/switch region; other site 1271864007895 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1271864007896 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1271864007897 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1271864007898 ligand binding site [chemical binding]; other site 1271864007899 calcium binding site [ion binding]; other site 1271864007900 Predicted membrane protein [Function unknown]; Region: COG2311 1271864007901 hypothetical protein; Provisional; Region: PRK10835 1271864007902 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1271864007903 GTP cyclohydrolase I; Provisional; Region: PLN03044 1271864007904 active site 1271864007905 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1271864007906 S-formylglutathione hydrolase; Region: PLN02442 1271864007907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864007908 non-specific DNA binding site [nucleotide binding]; other site 1271864007909 salt bridge; other site 1271864007910 sequence-specific DNA binding site [nucleotide binding]; other site 1271864007911 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1271864007912 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1271864007913 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1271864007914 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1271864007915 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1271864007916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864007917 motif II; other site 1271864007918 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1271864007919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864007920 putative substrate translocation pore; other site 1271864007921 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1271864007922 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864007923 N-terminal plug; other site 1271864007924 ligand-binding site [chemical binding]; other site 1271864007925 lysine transporter; Provisional; Region: PRK10836 1271864007926 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1271864007927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864007928 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1271864007929 putative dimerization interface [polypeptide binding]; other site 1271864007930 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1271864007931 endonuclease IV; Provisional; Region: PRK01060 1271864007932 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1271864007933 AP (apurinic/apyrimidinic) site pocket; other site 1271864007934 DNA interaction; other site 1271864007935 Metal-binding active site; metal-binding site 1271864007936 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1271864007937 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1271864007938 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1271864007939 active site 1271864007940 P-loop; other site 1271864007941 phosphorylation site [posttranslational modification] 1271864007942 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1271864007943 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1271864007944 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1271864007945 putative substrate binding site [chemical binding]; other site 1271864007946 putative ATP binding site [chemical binding]; other site 1271864007947 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1271864007948 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864007949 active site 1271864007950 phosphorylation site [posttranslational modification] 1271864007951 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1271864007952 dimerization domain swap beta strand [polypeptide binding]; other site 1271864007953 regulatory protein interface [polypeptide binding]; other site 1271864007954 active site 1271864007955 regulatory phosphorylation site [posttranslational modification]; other site 1271864007956 sugar efflux transporter B; Provisional; Region: PRK15011 1271864007957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864007958 putative substrate translocation pore; other site 1271864007959 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1271864007960 elongation factor P; Provisional; Region: PRK04542 1271864007961 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1271864007962 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1271864007963 RNA binding site [nucleotide binding]; other site 1271864007964 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1271864007965 RNA binding site [nucleotide binding]; other site 1271864007966 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1271864007967 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1271864007968 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1271864007969 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1271864007970 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1271864007971 active site 1271864007972 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1271864007973 NlpC/P60 family; Region: NLPC_P60; pfam00877 1271864007974 phage resistance protein; Provisional; Region: PRK10551 1271864007975 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1271864007976 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864007977 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1271864007978 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1271864007979 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1271864007980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864007981 dimer interface [polypeptide binding]; other site 1271864007982 conserved gate region; other site 1271864007983 putative PBP binding loops; other site 1271864007984 ABC-ATPase subunit interface; other site 1271864007985 microcin C ABC transporter permease; Provisional; Region: PRK15021 1271864007986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864007987 dimer interface [polypeptide binding]; other site 1271864007988 conserved gate region; other site 1271864007989 ABC-ATPase subunit interface; other site 1271864007990 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1271864007991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864007992 Walker A/P-loop; other site 1271864007993 ATP binding site [chemical binding]; other site 1271864007994 Q-loop/lid; other site 1271864007995 ABC transporter signature motif; other site 1271864007996 Walker B; other site 1271864007997 D-loop; other site 1271864007998 H-loop/switch region; other site 1271864007999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1271864008000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864008001 Walker A/P-loop; other site 1271864008002 ATP binding site [chemical binding]; other site 1271864008003 Q-loop/lid; other site 1271864008004 ABC transporter signature motif; other site 1271864008005 Walker B; other site 1271864008006 D-loop; other site 1271864008007 H-loop/switch region; other site 1271864008008 hypothetical protein; Provisional; Region: PRK11835 1271864008009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008010 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1271864008011 putative substrate translocation pore; other site 1271864008012 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1271864008013 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864008014 RNA binding surface [nucleotide binding]; other site 1271864008015 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1271864008016 active site 1271864008017 uracil binding [chemical binding]; other site 1271864008018 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1271864008019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864008020 ATP binding site [chemical binding]; other site 1271864008021 putative Mg++ binding site [ion binding]; other site 1271864008022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864008023 nucleotide binding region [chemical binding]; other site 1271864008024 ATP-binding site [chemical binding]; other site 1271864008025 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1271864008026 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1271864008027 5S rRNA interface [nucleotide binding]; other site 1271864008028 CTC domain interface [polypeptide binding]; other site 1271864008029 L16 interface [polypeptide binding]; other site 1271864008030 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1271864008031 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1271864008032 hypothetical protein; Provisional; Region: PRK13689 1271864008033 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1271864008034 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1271864008035 Sulfatase; Region: Sulfatase; cl17466 1271864008036 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1271864008037 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1271864008038 Catalytic site [active] 1271864008039 DinI-like family; Region: DinI; cl11630 1271864008040 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1271864008041 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1271864008042 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 1271864008043 Phage head maturation protease [General function prediction only]; Region: COG3740 1271864008044 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1271864008045 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1271864008046 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1271864008047 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1271864008048 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1271864008049 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1271864008050 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 1271864008051 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1271864008052 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1271864008053 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1271864008054 Leucine-rich repeats; other site 1271864008055 Substrate binding site [chemical binding]; other site 1271864008056 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1271864008057 DinI-like family; Region: DinI; cl11630 1271864008058 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1271864008059 transcriptional regulator NarP; Provisional; Region: PRK10403 1271864008060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864008061 active site 1271864008062 phosphorylation site [posttranslational modification] 1271864008063 intermolecular recognition site; other site 1271864008064 dimerization interface [polypeptide binding]; other site 1271864008065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864008066 DNA binding residues [nucleotide binding] 1271864008067 dimerization interface [polypeptide binding]; other site 1271864008068 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1271864008069 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1271864008070 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1271864008071 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1271864008072 catalytic residues [active] 1271864008073 central insert; other site 1271864008074 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1271864008075 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1271864008076 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1271864008077 heme exporter protein CcmC; Region: ccmC; TIGR01191 1271864008078 heme exporter protein CcmB; Region: ccmB; TIGR01190 1271864008079 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1271864008080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864008081 Walker A/P-loop; other site 1271864008082 ATP binding site [chemical binding]; other site 1271864008083 Q-loop/lid; other site 1271864008084 ABC transporter signature motif; other site 1271864008085 Walker B; other site 1271864008086 D-loop; other site 1271864008087 H-loop/switch region; other site 1271864008088 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1271864008089 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1271864008090 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1271864008091 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1271864008092 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1271864008093 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1271864008094 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1271864008095 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1271864008096 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1271864008097 [4Fe-4S] binding site [ion binding]; other site 1271864008098 molybdopterin cofactor binding site; other site 1271864008099 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1271864008100 molybdopterin cofactor binding site; other site 1271864008101 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1271864008102 ferredoxin-type protein; Provisional; Region: PRK10194 1271864008103 4Fe-4S binding domain; Region: Fer4; cl02805 1271864008104 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1271864008105 secondary substrate binding site; other site 1271864008106 primary substrate binding site; other site 1271864008107 inhibition loop; other site 1271864008108 dimerization interface [polypeptide binding]; other site 1271864008109 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1271864008110 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1271864008111 Walker A/P-loop; other site 1271864008112 ATP binding site [chemical binding]; other site 1271864008113 Q-loop/lid; other site 1271864008114 ABC transporter signature motif; other site 1271864008115 Walker B; other site 1271864008116 D-loop; other site 1271864008117 H-loop/switch region; other site 1271864008118 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1271864008119 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1271864008120 DNA binding site [nucleotide binding] 1271864008121 active site 1271864008122 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1271864008123 ApbE family; Region: ApbE; pfam02424 1271864008124 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1271864008125 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1271864008126 trimer interface [polypeptide binding]; other site 1271864008127 eyelet of channel; other site 1271864008128 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1271864008129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864008130 ATP binding site [chemical binding]; other site 1271864008131 G-X-G motif; other site 1271864008132 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1271864008133 putative binding surface; other site 1271864008134 active site 1271864008135 transcriptional regulator RcsB; Provisional; Region: PRK10840 1271864008136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864008137 active site 1271864008138 phosphorylation site [posttranslational modification] 1271864008139 intermolecular recognition site; other site 1271864008140 dimerization interface [polypeptide binding]; other site 1271864008141 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864008142 DNA binding residues [nucleotide binding] 1271864008143 dimerization interface [polypeptide binding]; other site 1271864008144 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1271864008145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864008146 dimer interface [polypeptide binding]; other site 1271864008147 phosphorylation site [posttranslational modification] 1271864008148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864008149 ATP binding site [chemical binding]; other site 1271864008150 Mg2+ binding site [ion binding]; other site 1271864008151 G-X-G motif; other site 1271864008152 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1271864008153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864008154 active site 1271864008155 phosphorylation site [posttranslational modification] 1271864008156 intermolecular recognition site; other site 1271864008157 dimerization interface [polypeptide binding]; other site 1271864008158 DNA gyrase subunit A; Validated; Region: PRK05560 1271864008159 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1271864008160 CAP-like domain; other site 1271864008161 active site 1271864008162 primary dimer interface [polypeptide binding]; other site 1271864008163 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1271864008164 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1271864008165 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1271864008166 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1271864008167 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1271864008168 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1271864008169 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1271864008170 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1271864008171 active site pocket [active] 1271864008172 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1271864008173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008174 putative substrate translocation pore; other site 1271864008175 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1271864008176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864008177 DNA-binding site [nucleotide binding]; DNA binding site 1271864008178 FCD domain; Region: FCD; pfam07729 1271864008179 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1271864008180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864008181 S-adenosylmethionine binding site [chemical binding]; other site 1271864008182 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1271864008183 ATP cone domain; Region: ATP-cone; pfam03477 1271864008184 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1271864008185 active site 1271864008186 dimer interface [polypeptide binding]; other site 1271864008187 catalytic residues [active] 1271864008188 effector binding site; other site 1271864008189 R2 peptide binding site; other site 1271864008190 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1271864008191 dimer interface [polypeptide binding]; other site 1271864008192 putative radical transfer pathway; other site 1271864008193 diiron center [ion binding]; other site 1271864008194 tyrosyl radical; other site 1271864008195 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1271864008196 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1271864008197 catalytic loop [active] 1271864008198 iron binding site [ion binding]; other site 1271864008199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864008200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008201 putative substrate translocation pore; other site 1271864008202 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1271864008203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864008204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1271864008205 dimerization interface [polypeptide binding]; other site 1271864008206 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1271864008207 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1271864008208 active site 1271864008209 catalytic site [active] 1271864008210 metal binding site [ion binding]; metal-binding site 1271864008211 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1271864008212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008213 putative substrate translocation pore; other site 1271864008214 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1271864008215 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1271864008216 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1271864008217 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1271864008218 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1271864008219 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1271864008220 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1271864008221 Cysteine-rich domain; Region: CCG; pfam02754 1271864008222 Cysteine-rich domain; Region: CCG; pfam02754 1271864008223 deubiquitinase SseL; Provisional; Region: PRK14848 1271864008224 hypothetical protein; Provisional; Region: PRK03673 1271864008225 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1271864008226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008227 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864008228 putative substrate translocation pore; other site 1271864008229 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1271864008230 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1271864008231 putative active site pocket [active] 1271864008232 putative metal binding site [ion binding]; other site 1271864008233 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1271864008234 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1271864008235 Bacterial transcriptional regulator; Region: IclR; pfam01614 1271864008236 hypothetical protein; Provisional; Region: PRK03673 1271864008237 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1271864008238 putative MPT binding site; other site 1271864008239 Competence-damaged protein; Region: CinA; cl00666 1271864008240 YfaZ precursor; Region: YfaZ; pfam07437 1271864008241 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1271864008242 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1271864008243 catalytic core [active] 1271864008244 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1271864008245 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1271864008246 inhibitor-cofactor binding pocket; inhibition site 1271864008247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864008248 catalytic residue [active] 1271864008249 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1271864008250 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1271864008251 Ligand binding site; other site 1271864008252 Putative Catalytic site; other site 1271864008253 DXD motif; other site 1271864008254 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1271864008255 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1271864008256 active site 1271864008257 substrate binding site [chemical binding]; other site 1271864008258 cosubstrate binding site; other site 1271864008259 catalytic site [active] 1271864008260 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1271864008261 active site 1271864008262 hexamer interface [polypeptide binding]; other site 1271864008263 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1271864008264 NAD binding site [chemical binding]; other site 1271864008265 substrate binding site [chemical binding]; other site 1271864008266 active site 1271864008267 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1271864008268 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1271864008269 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1271864008270 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1271864008271 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1271864008272 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1271864008273 signal transduction protein PmrD; Provisional; Region: PRK15450 1271864008274 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1271864008275 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1271864008276 acyl-activating enzyme (AAE) consensus motif; other site 1271864008277 putative AMP binding site [chemical binding]; other site 1271864008278 putative active site [active] 1271864008279 putative CoA binding site [chemical binding]; other site 1271864008280 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 1271864008281 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1271864008282 active site 1271864008283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1271864008284 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1271864008285 substrate binding site [chemical binding]; other site 1271864008286 oxyanion hole (OAH) forming residues; other site 1271864008287 trimer interface [polypeptide binding]; other site 1271864008288 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1271864008289 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1271864008290 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1271864008291 dimer interface [polypeptide binding]; other site 1271864008292 tetramer interface [polypeptide binding]; other site 1271864008293 PYR/PP interface [polypeptide binding]; other site 1271864008294 TPP binding site [chemical binding]; other site 1271864008295 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1271864008296 TPP-binding site; other site 1271864008297 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1271864008298 isochorismate synthases; Region: isochor_syn; TIGR00543 1271864008299 hypothetical protein; Provisional; Region: PRK10404 1271864008300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864008301 Coenzyme A binding pocket [chemical binding]; other site 1271864008302 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1271864008303 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1271864008304 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1271864008305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864008306 active site 1271864008307 phosphorylation site [posttranslational modification] 1271864008308 intermolecular recognition site; other site 1271864008309 dimerization interface [polypeptide binding]; other site 1271864008310 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1271864008311 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1271864008312 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1271864008313 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1271864008314 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1271864008315 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1271864008316 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1271864008317 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1271864008318 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1271864008319 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1271864008320 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1271864008321 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864008322 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864008323 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1271864008324 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1271864008325 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1271864008326 catalytic loop [active] 1271864008327 iron binding site [ion binding]; other site 1271864008328 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1271864008329 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1271864008330 [4Fe-4S] binding site [ion binding]; other site 1271864008331 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1271864008332 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1271864008333 SLBB domain; Region: SLBB; pfam10531 1271864008334 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1271864008335 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1271864008336 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1271864008337 putative dimer interface [polypeptide binding]; other site 1271864008338 [2Fe-2S] cluster binding site [ion binding]; other site 1271864008339 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1271864008340 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1271864008341 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1271864008342 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1271864008343 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1271864008344 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1271864008345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864008346 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1271864008347 putative dimerization interface [polypeptide binding]; other site 1271864008348 aminotransferase AlaT; Validated; Region: PRK09265 1271864008349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864008350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864008351 homodimer interface [polypeptide binding]; other site 1271864008352 catalytic residue [active] 1271864008353 5'-nucleotidase; Provisional; Region: PRK03826 1271864008354 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1271864008355 transmembrane helices; other site 1271864008356 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1271864008357 TrkA-C domain; Region: TrkA_C; pfam02080 1271864008358 TrkA-C domain; Region: TrkA_C; pfam02080 1271864008359 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1271864008360 putative phosphatase; Provisional; Region: PRK11587 1271864008361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864008362 motif II; other site 1271864008363 hypothetical protein; Validated; Region: PRK05445 1271864008364 hypothetical protein; Provisional; Region: PRK01816 1271864008365 propionate/acetate kinase; Provisional; Region: PRK12379 1271864008366 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1271864008367 phosphate acetyltransferase; Reviewed; Region: PRK05632 1271864008368 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1271864008369 DRTGG domain; Region: DRTGG; pfam07085 1271864008370 phosphate acetyltransferase; Region: pta; TIGR00651 1271864008371 hypothetical protein; Provisional; Region: PRK11588 1271864008372 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1271864008373 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1271864008374 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1271864008375 PYR/PP interface [polypeptide binding]; other site 1271864008376 dimer interface [polypeptide binding]; other site 1271864008377 TPP binding site [chemical binding]; other site 1271864008378 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1271864008379 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1271864008380 TPP-binding site [chemical binding]; other site 1271864008381 dimer interface [polypeptide binding]; other site 1271864008382 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1271864008383 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1271864008384 active site 1271864008385 P-loop; other site 1271864008386 phosphorylation site [posttranslational modification] 1271864008387 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864008388 active site 1271864008389 phosphorylation site [posttranslational modification] 1271864008390 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1271864008391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864008392 DNA binding site [nucleotide binding] 1271864008393 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1271864008394 putative dimerization interface [polypeptide binding]; other site 1271864008395 putative ligand binding site [chemical binding]; other site 1271864008396 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1271864008397 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1271864008398 nudix motif; other site 1271864008399 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1271864008400 active site 1271864008401 metal binding site [ion binding]; metal-binding site 1271864008402 homotetramer interface [polypeptide binding]; other site 1271864008403 glutathione S-transferase; Provisional; Region: PRK15113 1271864008404 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1271864008405 C-terminal domain interface [polypeptide binding]; other site 1271864008406 GSH binding site (G-site) [chemical binding]; other site 1271864008407 dimer interface [polypeptide binding]; other site 1271864008408 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1271864008409 N-terminal domain interface [polypeptide binding]; other site 1271864008410 putative dimer interface [polypeptide binding]; other site 1271864008411 putative substrate binding pocket (H-site) [chemical binding]; other site 1271864008412 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1271864008413 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1271864008414 C-terminal domain interface [polypeptide binding]; other site 1271864008415 GSH binding site (G-site) [chemical binding]; other site 1271864008416 dimer interface [polypeptide binding]; other site 1271864008417 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1271864008418 N-terminal domain interface [polypeptide binding]; other site 1271864008419 putative dimer interface [polypeptide binding]; other site 1271864008420 active site 1271864008421 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1271864008422 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1271864008423 putative NAD(P) binding site [chemical binding]; other site 1271864008424 putative active site [active] 1271864008425 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1271864008426 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1271864008427 Walker A/P-loop; other site 1271864008428 ATP binding site [chemical binding]; other site 1271864008429 Q-loop/lid; other site 1271864008430 ABC transporter signature motif; other site 1271864008431 Walker B; other site 1271864008432 D-loop; other site 1271864008433 H-loop/switch region; other site 1271864008434 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864008435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864008436 dimer interface [polypeptide binding]; other site 1271864008437 conserved gate region; other site 1271864008438 putative PBP binding loops; other site 1271864008439 ABC-ATPase subunit interface; other site 1271864008440 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1271864008441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864008442 dimer interface [polypeptide binding]; other site 1271864008443 conserved gate region; other site 1271864008444 putative PBP binding loops; other site 1271864008445 ABC-ATPase subunit interface; other site 1271864008446 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1271864008447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864008448 substrate binding pocket [chemical binding]; other site 1271864008449 membrane-bound complex binding site; other site 1271864008450 hinge residues; other site 1271864008451 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1271864008452 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864008453 substrate binding pocket [chemical binding]; other site 1271864008454 membrane-bound complex binding site; other site 1271864008455 hinge residues; other site 1271864008456 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1271864008457 Flavoprotein; Region: Flavoprotein; pfam02441 1271864008458 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1271864008459 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1271864008460 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1271864008461 dimer interface [polypeptide binding]; other site 1271864008462 active site 1271864008463 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1271864008464 substrate binding site [chemical binding]; other site 1271864008465 catalytic residue [active] 1271864008466 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1271864008467 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1271864008468 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1271864008469 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1271864008470 catalytic residue [active] 1271864008471 PAS fold; Region: PAS_4; pfam08448 1271864008472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1271864008473 putative active site [active] 1271864008474 heme pocket [chemical binding]; other site 1271864008475 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1271864008476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864008477 Walker A motif; other site 1271864008478 ATP binding site [chemical binding]; other site 1271864008479 Walker B motif; other site 1271864008480 arginine finger; other site 1271864008481 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1271864008482 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1271864008483 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1271864008484 active site 1271864008485 tetramer interface [polypeptide binding]; other site 1271864008486 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864008487 active site 1271864008488 colicin V production protein; Provisional; Region: PRK10845 1271864008489 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1271864008490 cell division protein DedD; Provisional; Region: PRK11633 1271864008491 Sporulation related domain; Region: SPOR; pfam05036 1271864008492 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1271864008493 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1271864008494 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1271864008495 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1271864008496 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1271864008497 hypothetical protein; Provisional; Region: PRK10847 1271864008498 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1271864008499 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1271864008500 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1271864008501 dimerization interface 3.5A [polypeptide binding]; other site 1271864008502 active site 1271864008503 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1271864008504 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1271864008505 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1271864008506 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1271864008507 ligand binding site [chemical binding]; other site 1271864008508 NAD binding site [chemical binding]; other site 1271864008509 catalytic site [active] 1271864008510 homodimer interface [polypeptide binding]; other site 1271864008511 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1271864008512 putative transporter; Provisional; Region: PRK12382 1271864008513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008514 putative substrate translocation pore; other site 1271864008515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864008516 non-specific DNA binding site [nucleotide binding]; other site 1271864008517 salt bridge; other site 1271864008518 sequence-specific DNA binding site [nucleotide binding]; other site 1271864008519 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1271864008520 CAAX protease self-immunity; Region: Abi; pfam02517 1271864008521 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1271864008522 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1271864008523 dimer interface [polypeptide binding]; other site 1271864008524 active site 1271864008525 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1271864008526 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1271864008527 YfcL protein; Region: YfcL; pfam08891 1271864008528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1271864008529 hypothetical protein; Provisional; Region: PRK10621 1271864008530 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1271864008531 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1271864008532 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1271864008533 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1271864008534 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1271864008535 Tetramer interface [polypeptide binding]; other site 1271864008536 active site 1271864008537 FMN-binding site [chemical binding]; other site 1271864008538 HemK family putative methylases; Region: hemK_fam; TIGR00536 1271864008539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864008540 S-adenosylmethionine binding site [chemical binding]; other site 1271864008541 hypothetical protein; Provisional; Region: PRK04946 1271864008542 Smr domain; Region: Smr; pfam01713 1271864008543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1271864008544 catalytic core [active] 1271864008545 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1271864008546 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1271864008547 substrate binding site [chemical binding]; other site 1271864008548 oxyanion hole (OAH) forming residues; other site 1271864008549 trimer interface [polypeptide binding]; other site 1271864008550 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1271864008551 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1271864008552 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1271864008553 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1271864008554 dimer interface [polypeptide binding]; other site 1271864008555 active site 1271864008556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1271864008557 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1271864008558 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1271864008559 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1271864008560 integrase; Provisional; Region: PRK09692 1271864008561 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1271864008562 active site 1271864008563 Int/Topo IB signature motif; other site 1271864008564 AIPR protein; Region: AIPR; pfam10592 1271864008565 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1271864008566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1271864008567 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1271864008568 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1271864008569 active site 1271864008570 metal binding site [ion binding]; metal-binding site 1271864008571 interdomain interaction site; other site 1271864008572 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1271864008573 Ash protein family; Region: Phage_ASH; pfam10554 1271864008574 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1271864008575 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1271864008576 outer membrane protease; Reviewed; Region: PRK10993 1271864008577 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1271864008578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864008579 active site 1271864008580 phosphorylation site [posttranslational modification] 1271864008581 intermolecular recognition site; other site 1271864008582 dimerization interface [polypeptide binding]; other site 1271864008583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1271864008584 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1271864008585 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1271864008586 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1271864008587 dimerization interface [polypeptide binding]; other site 1271864008588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864008589 dimer interface [polypeptide binding]; other site 1271864008590 phosphorylation site [posttranslational modification] 1271864008591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864008592 ATP binding site [chemical binding]; other site 1271864008593 Mg2+ binding site [ion binding]; other site 1271864008594 G-X-G motif; other site 1271864008595 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1271864008596 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1271864008597 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1271864008598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008600 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1271864008601 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1271864008602 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1271864008603 putative acyl-acceptor binding pocket; other site 1271864008604 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1271864008605 aminotransferase; Validated; Region: PRK08175 1271864008606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864008607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864008608 homodimer interface [polypeptide binding]; other site 1271864008609 catalytic residue [active] 1271864008610 glucokinase; Provisional; Region: glk; PRK00292 1271864008611 glucokinase, proteobacterial type; Region: glk; TIGR00749 1271864008612 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1271864008613 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1271864008614 Cl- selectivity filter; other site 1271864008615 Cl- binding residues [ion binding]; other site 1271864008616 pore gating glutamate residue; other site 1271864008617 dimer interface [polypeptide binding]; other site 1271864008618 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1271864008619 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1271864008620 dimer interface [polypeptide binding]; other site 1271864008621 PYR/PP interface [polypeptide binding]; other site 1271864008622 TPP binding site [chemical binding]; other site 1271864008623 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1271864008624 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1271864008625 TPP-binding site [chemical binding]; other site 1271864008626 dimer interface [polypeptide binding]; other site 1271864008627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864008628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864008629 active site 1271864008630 catalytic tetrad [active] 1271864008631 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1271864008632 manganese transport protein MntH; Reviewed; Region: PRK00701 1271864008633 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1271864008634 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1271864008635 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1271864008636 Nucleoside recognition; Region: Gate; pfam07670 1271864008637 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1271864008638 MASE1; Region: MASE1; pfam05231 1271864008639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1271864008640 diguanylate cyclase; Region: GGDEF; smart00267 1271864008641 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864008642 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1271864008643 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1271864008644 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1271864008645 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1271864008646 active site 1271864008647 HIGH motif; other site 1271864008648 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1271864008649 active site 1271864008650 KMSKS motif; other site 1271864008651 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1271864008652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864008653 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1271864008654 putative dimerization interface [polypeptide binding]; other site 1271864008655 putative substrate binding pocket [chemical binding]; other site 1271864008656 XapX domain; Region: XapX; TIGR03510 1271864008657 nucleoside transporter; Region: 2A0110; TIGR00889 1271864008658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864008659 putative substrate translocation pore; other site 1271864008660 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1271864008661 hypothetical protein; Provisional; Region: PRK11528 1271864008662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864008663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864008664 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1271864008665 putative dimerization interface [polypeptide binding]; other site 1271864008666 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1271864008667 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1271864008668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1271864008669 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1271864008670 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1271864008671 nucleotide binding pocket [chemical binding]; other site 1271864008672 K-X-D-G motif; other site 1271864008673 catalytic site [active] 1271864008674 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1271864008675 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1271864008676 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1271864008677 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1271864008678 Dimer interface [polypeptide binding]; other site 1271864008679 BRCT sequence motif; other site 1271864008680 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1271864008681 cell division protein ZipA; Provisional; Region: PRK03427 1271864008682 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1271864008683 FtsZ protein binding site [polypeptide binding]; other site 1271864008684 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1271864008685 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1271864008686 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1271864008687 dimer interface [polypeptide binding]; other site 1271864008688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864008689 catalytic residue [active] 1271864008690 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1271864008691 dimerization domain swap beta strand [polypeptide binding]; other site 1271864008692 regulatory protein interface [polypeptide binding]; other site 1271864008693 active site 1271864008694 regulatory phosphorylation site [posttranslational modification]; other site 1271864008695 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1271864008696 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1271864008697 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1271864008698 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1271864008699 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1271864008700 HPr interaction site; other site 1271864008701 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1271864008702 active site 1271864008703 phosphorylation site [posttranslational modification] 1271864008704 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1271864008705 dimer interface [polypeptide binding]; other site 1271864008706 pyridoxamine kinase; Validated; Region: PRK05756 1271864008707 pyridoxal binding site [chemical binding]; other site 1271864008708 ATP binding site [chemical binding]; other site 1271864008709 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1271864008710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864008711 DNA-binding site [nucleotide binding]; DNA binding site 1271864008712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864008713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864008714 homodimer interface [polypeptide binding]; other site 1271864008715 catalytic residue [active] 1271864008716 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1271864008717 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1271864008718 catalytic triad [active] 1271864008719 hypothetical protein; Provisional; Region: PRK10318 1271864008720 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1271864008721 Sel1-like repeats; Region: SEL1; smart00671 1271864008722 cysteine synthase B; Region: cysM; TIGR01138 1271864008723 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1271864008724 dimer interface [polypeptide binding]; other site 1271864008725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864008726 catalytic residue [active] 1271864008727 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1271864008728 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1271864008729 Walker A/P-loop; other site 1271864008730 ATP binding site [chemical binding]; other site 1271864008731 Q-loop/lid; other site 1271864008732 ABC transporter signature motif; other site 1271864008733 Walker B; other site 1271864008734 D-loop; other site 1271864008735 H-loop/switch region; other site 1271864008736 TOBE-like domain; Region: TOBE_3; pfam12857 1271864008737 sulfate transport protein; Provisional; Region: cysT; CHL00187 1271864008738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864008739 dimer interface [polypeptide binding]; other site 1271864008740 conserved gate region; other site 1271864008741 putative PBP binding loops; other site 1271864008742 ABC-ATPase subunit interface; other site 1271864008743 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1271864008744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864008745 dimer interface [polypeptide binding]; other site 1271864008746 conserved gate region; other site 1271864008747 putative PBP binding loops; other site 1271864008748 ABC-ATPase subunit interface; other site 1271864008749 thiosulfate transporter subunit; Provisional; Region: PRK10852 1271864008750 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1271864008751 short chain dehydrogenase; Provisional; Region: PRK08226 1271864008752 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1271864008753 NAD binding site [chemical binding]; other site 1271864008754 homotetramer interface [polypeptide binding]; other site 1271864008755 homodimer interface [polypeptide binding]; other site 1271864008756 active site 1271864008757 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1271864008758 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1271864008759 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1271864008760 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1271864008761 putative acetyltransferase; Provisional; Region: PRK03624 1271864008762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864008763 Coenzyme A binding pocket [chemical binding]; other site 1271864008764 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1271864008765 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1271864008766 active site 1271864008767 metal binding site [ion binding]; metal-binding site 1271864008768 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1271864008769 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1271864008770 transcriptional regulator EutR; Provisional; Region: PRK10130 1271864008771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864008772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864008773 carboxysome structural protein EutK; Provisional; Region: PRK15466 1271864008774 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1271864008775 Hexamer interface [polypeptide binding]; other site 1271864008776 Hexagonal pore residue; other site 1271864008777 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1271864008778 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1271864008779 putative hexamer interface [polypeptide binding]; other site 1271864008780 putative hexagonal pore; other site 1271864008781 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1271864008782 putative hexamer interface [polypeptide binding]; other site 1271864008783 putative hexagonal pore; other site 1271864008784 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1271864008785 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1271864008786 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1271864008787 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1271864008788 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1271864008789 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1271864008790 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1271864008791 active site 1271864008792 metal binding site [ion binding]; metal-binding site 1271864008793 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1271864008794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864008795 nucleotide binding site [chemical binding]; other site 1271864008796 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1271864008797 putative catalytic cysteine [active] 1271864008798 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1271864008799 Hexamer/Pentamer interface [polypeptide binding]; other site 1271864008800 central pore; other site 1271864008801 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1271864008802 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1271864008803 Hexamer interface [polypeptide binding]; other site 1271864008804 Putative hexagonal pore residue; other site 1271864008805 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1271864008806 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1271864008807 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1271864008808 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1271864008809 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1271864008810 G1 box; other site 1271864008811 GTP/Mg2+ binding site [chemical binding]; other site 1271864008812 G2 box; other site 1271864008813 Switch I region; other site 1271864008814 G3 box; other site 1271864008815 Switch II region; other site 1271864008816 G4 box; other site 1271864008817 G5 box; other site 1271864008818 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1271864008819 putative hexamer interface [polypeptide binding]; other site 1271864008820 putative hexagonal pore; other site 1271864008821 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1271864008822 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1271864008823 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1271864008824 putative NAD(P) binding site [chemical binding]; other site 1271864008825 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1271864008826 transaldolase-like protein; Provisional; Region: PTZ00411 1271864008827 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1271864008828 active site 1271864008829 dimer interface [polypeptide binding]; other site 1271864008830 catalytic residue [active] 1271864008831 transketolase; Reviewed; Region: PRK12753 1271864008832 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1271864008833 TPP-binding site [chemical binding]; other site 1271864008834 dimer interface [polypeptide binding]; other site 1271864008835 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1271864008836 PYR/PP interface [polypeptide binding]; other site 1271864008837 dimer interface [polypeptide binding]; other site 1271864008838 TPP binding site [chemical binding]; other site 1271864008839 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1271864008840 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1271864008841 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1271864008842 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1271864008843 dimer interface [polypeptide binding]; other site 1271864008844 ADP-ribose binding site [chemical binding]; other site 1271864008845 active site 1271864008846 nudix motif; other site 1271864008847 metal binding site [ion binding]; metal-binding site 1271864008848 putative periplasmic esterase; Provisional; Region: PRK03642 1271864008849 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1271864008850 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1271864008851 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864008852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1271864008853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864008854 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1271864008855 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1271864008856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864008857 dimerization interface [polypeptide binding]; other site 1271864008858 Histidine kinase; Region: HisKA_3; pfam07730 1271864008859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864008860 ATP binding site [chemical binding]; other site 1271864008861 Mg2+ binding site [ion binding]; other site 1271864008862 G-X-G motif; other site 1271864008863 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1271864008864 Protein export membrane protein; Region: SecD_SecF; cl14618 1271864008865 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1271864008866 ArsC family; Region: ArsC; pfam03960 1271864008867 putative catalytic residues [active] 1271864008868 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1271864008869 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1271864008870 metal binding site [ion binding]; metal-binding site 1271864008871 dimer interface [polypeptide binding]; other site 1271864008872 hypothetical protein; Provisional; Region: PRK13664 1271864008873 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1271864008874 Helicase; Region: Helicase_RecD; pfam05127 1271864008875 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1271864008876 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1271864008877 Predicted metalloprotease [General function prediction only]; Region: COG2321 1271864008878 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1271864008879 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1271864008880 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1271864008881 ATP binding site [chemical binding]; other site 1271864008882 active site 1271864008883 substrate binding site [chemical binding]; other site 1271864008884 lipoprotein; Provisional; Region: PRK11679 1271864008885 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1271864008886 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1271864008887 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1271864008888 dimer interface [polypeptide binding]; other site 1271864008889 active site 1271864008890 catalytic residue [active] 1271864008891 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1271864008892 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1271864008893 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1271864008894 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1271864008895 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1271864008896 catalytic triad [active] 1271864008897 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1271864008898 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1271864008899 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1271864008900 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1271864008901 Peptidase family M48; Region: Peptidase_M48; cl12018 1271864008902 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1271864008903 ArsC family; Region: ArsC; pfam03960 1271864008904 catalytic residues [active] 1271864008905 DNA replication initiation factor; Provisional; Region: PRK08084 1271864008906 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1271864008907 uracil transporter; Provisional; Region: PRK10720 1271864008908 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864008909 active site 1271864008910 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1271864008911 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1271864008912 dimerization interface [polypeptide binding]; other site 1271864008913 putative ATP binding site [chemical binding]; other site 1271864008914 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1271864008915 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1271864008916 active site 1271864008917 substrate binding site [chemical binding]; other site 1271864008918 cosubstrate binding site; other site 1271864008919 catalytic site [active] 1271864008920 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1271864008921 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1271864008922 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1271864008923 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1271864008924 putative active site [active] 1271864008925 catalytic site [active] 1271864008926 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1271864008927 domain interface [polypeptide binding]; other site 1271864008928 active site 1271864008929 catalytic site [active] 1271864008930 exopolyphosphatase; Provisional; Region: PRK10854 1271864008931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864008932 nucleotide binding site [chemical binding]; other site 1271864008933 MASE1; Region: MASE1; pfam05231 1271864008934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1271864008935 diguanylate cyclase; Region: GGDEF; smart00267 1271864008936 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864008937 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1271864008938 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1271864008939 Integrase core domain; Region: rve; pfam00665 1271864008940 GMP synthase; Reviewed; Region: guaA; PRK00074 1271864008941 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1271864008942 AMP/PPi binding site [chemical binding]; other site 1271864008943 candidate oxyanion hole; other site 1271864008944 catalytic triad [active] 1271864008945 potential glutamine specificity residues [chemical binding]; other site 1271864008946 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1271864008947 ATP Binding subdomain [chemical binding]; other site 1271864008948 Ligand Binding sites [chemical binding]; other site 1271864008949 Dimerization subdomain; other site 1271864008950 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1271864008951 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1271864008952 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1271864008953 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1271864008954 active site 1271864008955 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1271864008956 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1271864008957 generic binding surface II; other site 1271864008958 generic binding surface I; other site 1271864008959 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 1271864008960 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1271864008961 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1271864008962 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1271864008963 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1271864008964 Autotransporter beta-domain; Region: Autotransporter; smart00869 1271864008965 outer membrane protein RatB; Provisional; Region: PRK15314 1271864008966 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008967 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008968 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008969 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008970 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008971 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008972 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008973 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008974 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008975 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008976 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008977 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008978 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008979 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008980 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008981 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008982 outer membrane protein RatA; Provisional; Region: PRK15315 1271864008983 Oxygen tolerance; Region: BatD; pfam13584 1271864008984 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008985 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008986 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008987 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008988 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008989 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008990 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008991 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008992 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008993 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1271864008994 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1271864008995 intimin-like protein SinH; Provisional; Region: PRK15318 1271864008996 intimin-like protein SinH; Provisional; Region: PRK15318 1271864008997 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1271864008998 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1271864008999 GTP-binding protein Der; Reviewed; Region: PRK00093 1271864009000 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1271864009001 G1 box; other site 1271864009002 GTP/Mg2+ binding site [chemical binding]; other site 1271864009003 Switch I region; other site 1271864009004 G2 box; other site 1271864009005 Switch II region; other site 1271864009006 G3 box; other site 1271864009007 G4 box; other site 1271864009008 G5 box; other site 1271864009009 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1271864009010 G1 box; other site 1271864009011 GTP/Mg2+ binding site [chemical binding]; other site 1271864009012 Switch I region; other site 1271864009013 G2 box; other site 1271864009014 G3 box; other site 1271864009015 Switch II region; other site 1271864009016 G4 box; other site 1271864009017 G5 box; other site 1271864009018 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1271864009019 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1271864009020 Trp docking motif [polypeptide binding]; other site 1271864009021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1271864009022 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1271864009023 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1271864009024 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1271864009025 dimer interface [polypeptide binding]; other site 1271864009026 motif 1; other site 1271864009027 active site 1271864009028 motif 2; other site 1271864009029 motif 3; other site 1271864009030 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1271864009031 anticodon binding site; other site 1271864009032 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1271864009033 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1271864009034 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1271864009035 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1271864009036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864009037 non-specific DNA binding site [nucleotide binding]; other site 1271864009038 salt bridge; other site 1271864009039 sequence-specific DNA binding site [nucleotide binding]; other site 1271864009040 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1271864009041 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1271864009042 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864009043 FeS/SAM binding site; other site 1271864009044 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1271864009045 active site 1271864009046 multimer interface [polypeptide binding]; other site 1271864009047 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864009048 hydrogenase 4 subunit H; Validated; Region: PRK08222 1271864009049 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1271864009050 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1271864009051 4Fe-4S binding domain; Region: Fer4; pfam00037 1271864009052 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1271864009053 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1271864009054 putative [Fe4-S4] binding site [ion binding]; other site 1271864009055 putative molybdopterin cofactor binding site [chemical binding]; other site 1271864009056 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1271864009057 putative molybdopterin cofactor binding site; other site 1271864009058 penicillin-binding protein 1C; Provisional; Region: PRK11240 1271864009059 Transglycosylase; Region: Transgly; pfam00912 1271864009060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1271864009061 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1271864009062 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1271864009063 MG2 domain; Region: A2M_N; pfam01835 1271864009064 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1271864009065 surface patch; other site 1271864009066 thioester region; other site 1271864009067 specificity defining residues; other site 1271864009068 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1271864009069 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1271864009070 active site residue [active] 1271864009071 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1271864009072 active site residue [active] 1271864009073 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1271864009074 aminopeptidase B; Provisional; Region: PRK05015 1271864009075 Peptidase; Region: DUF3663; pfam12404 1271864009076 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1271864009077 interface (dimer of trimers) [polypeptide binding]; other site 1271864009078 Substrate-binding/catalytic site; other site 1271864009079 Zn-binding sites [ion binding]; other site 1271864009080 hypothetical protein; Provisional; Region: PRK10721 1271864009081 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1271864009082 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1271864009083 catalytic loop [active] 1271864009084 iron binding site [ion binding]; other site 1271864009085 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1271864009086 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1271864009087 nucleotide binding site [chemical binding]; other site 1271864009088 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1271864009089 SBD interface [polypeptide binding]; other site 1271864009090 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1271864009091 DnaJ domain; Region: DnaJ; pfam00226 1271864009092 HSP70 interaction site [polypeptide binding]; other site 1271864009093 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1271864009094 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1271864009095 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1271864009096 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1271864009097 trimerization site [polypeptide binding]; other site 1271864009098 active site 1271864009099 cysteine desulfurase; Provisional; Region: PRK14012 1271864009100 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1271864009101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864009102 catalytic residue [active] 1271864009103 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1271864009104 Rrf2 family protein; Region: rrf2_super; TIGR00738 1271864009105 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1271864009106 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1271864009107 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1271864009108 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1271864009109 active site 1271864009110 dimerization interface [polypeptide binding]; other site 1271864009111 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1271864009112 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1271864009113 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 1271864009114 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1271864009115 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1271864009116 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1271864009117 FAD binding pocket [chemical binding]; other site 1271864009118 FAD binding motif [chemical binding]; other site 1271864009119 phosphate binding motif [ion binding]; other site 1271864009120 beta-alpha-beta structure motif; other site 1271864009121 NAD binding pocket [chemical binding]; other site 1271864009122 Iron coordination center [ion binding]; other site 1271864009123 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 1271864009124 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1271864009125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1271864009126 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1271864009127 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1271864009128 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1271864009129 PRD domain; Region: PRD; pfam00874 1271864009130 PRD domain; Region: PRD; pfam00874 1271864009131 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1271864009132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009133 putative substrate translocation pore; other site 1271864009134 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1271864009135 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1271864009136 dimer interface [polypeptide binding]; other site 1271864009137 active site 1271864009138 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1271864009139 folate binding site [chemical binding]; other site 1271864009140 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1271864009141 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1271864009142 heme-binding site [chemical binding]; other site 1271864009143 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1271864009144 FAD binding pocket [chemical binding]; other site 1271864009145 FAD binding motif [chemical binding]; other site 1271864009146 phosphate binding motif [ion binding]; other site 1271864009147 beta-alpha-beta structure motif; other site 1271864009148 NAD binding pocket [chemical binding]; other site 1271864009149 Heme binding pocket [chemical binding]; other site 1271864009150 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1271864009151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864009152 DNA binding site [nucleotide binding] 1271864009153 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1271864009154 lysine decarboxylase CadA; Provisional; Region: PRK15400 1271864009155 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1271864009156 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1271864009157 homodimer interface [polypeptide binding]; other site 1271864009158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864009159 catalytic residue [active] 1271864009160 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1271864009161 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1271864009162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009163 putative substrate translocation pore; other site 1271864009164 POT family; Region: PTR2; pfam00854 1271864009165 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1271864009166 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1271864009167 response regulator GlrR; Provisional; Region: PRK15115 1271864009168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864009169 active site 1271864009170 phosphorylation site [posttranslational modification] 1271864009171 intermolecular recognition site; other site 1271864009172 dimerization interface [polypeptide binding]; other site 1271864009173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864009174 Walker A motif; other site 1271864009175 ATP binding site [chemical binding]; other site 1271864009176 Walker B motif; other site 1271864009177 arginine finger; other site 1271864009178 hypothetical protein; Provisional; Region: PRK10722 1271864009179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1271864009180 HAMP domain; Region: HAMP; pfam00672 1271864009181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864009182 dimer interface [polypeptide binding]; other site 1271864009183 phosphorylation site [posttranslational modification] 1271864009184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864009185 ATP binding site [chemical binding]; other site 1271864009186 Mg2+ binding site [ion binding]; other site 1271864009187 G-X-G motif; other site 1271864009188 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1271864009189 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1271864009190 dimerization interface [polypeptide binding]; other site 1271864009191 ATP binding site [chemical binding]; other site 1271864009192 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 1271864009193 dimerization interface [polypeptide binding]; other site 1271864009194 ATP binding site [chemical binding]; other site 1271864009195 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1271864009196 putative active site [active] 1271864009197 catalytic triad [active] 1271864009198 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1271864009199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864009200 substrate binding pocket [chemical binding]; other site 1271864009201 membrane-bound complex binding site; other site 1271864009202 hinge residues; other site 1271864009203 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864009204 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864009205 catalytic residue [active] 1271864009206 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1271864009207 nucleoside/Zn binding site; other site 1271864009208 dimer interface [polypeptide binding]; other site 1271864009209 catalytic motif [active] 1271864009210 hypothetical protein; Provisional; Region: PRK11590 1271864009211 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1271864009212 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1271864009213 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1271864009214 active site turn [active] 1271864009215 phosphorylation site [posttranslational modification] 1271864009216 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1271864009217 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1271864009218 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1271864009219 putative active site [active] 1271864009220 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1271864009221 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1271864009222 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1271864009223 putative active site [active] 1271864009224 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1271864009225 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1271864009226 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1271864009227 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1271864009228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009229 putative substrate translocation pore; other site 1271864009230 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864009231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864009232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1271864009233 dimerization interface [polypeptide binding]; other site 1271864009234 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1271864009235 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1271864009236 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1271864009237 active site 1271864009238 hydrophilic channel; other site 1271864009239 dimerization interface [polypeptide binding]; other site 1271864009240 catalytic residues [active] 1271864009241 active site lid [active] 1271864009242 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1271864009243 Recombination protein O N terminal; Region: RecO_N; pfam11967 1271864009244 Recombination protein O C terminal; Region: RecO_C; pfam02565 1271864009245 GTPase Era; Reviewed; Region: era; PRK00089 1271864009246 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1271864009247 G1 box; other site 1271864009248 GTP/Mg2+ binding site [chemical binding]; other site 1271864009249 Switch I region; other site 1271864009250 G2 box; other site 1271864009251 Switch II region; other site 1271864009252 G3 box; other site 1271864009253 G4 box; other site 1271864009254 G5 box; other site 1271864009255 KH domain; Region: KH_2; pfam07650 1271864009256 ribonuclease III; Reviewed; Region: rnc; PRK00102 1271864009257 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1271864009258 dimerization interface [polypeptide binding]; other site 1271864009259 active site 1271864009260 metal binding site [ion binding]; metal-binding site 1271864009261 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1271864009262 dsRNA binding site [nucleotide binding]; other site 1271864009263 signal peptidase I; Provisional; Region: PRK10861 1271864009264 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1271864009265 Catalytic site [active] 1271864009266 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1271864009267 GTP-binding protein LepA; Provisional; Region: PRK05433 1271864009268 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1271864009269 G1 box; other site 1271864009270 putative GEF interaction site [polypeptide binding]; other site 1271864009271 GTP/Mg2+ binding site [chemical binding]; other site 1271864009272 Switch I region; other site 1271864009273 G2 box; other site 1271864009274 G3 box; other site 1271864009275 Switch II region; other site 1271864009276 G4 box; other site 1271864009277 G5 box; other site 1271864009278 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1271864009279 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1271864009280 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1271864009281 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1271864009282 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1271864009283 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1271864009284 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1271864009285 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1271864009286 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1271864009287 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1271864009288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1271864009289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1271864009290 DNA binding residues [nucleotide binding] 1271864009291 L-aspartate oxidase; Provisional; Region: PRK09077 1271864009292 L-aspartate oxidase; Provisional; Region: PRK06175 1271864009293 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1271864009294 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1271864009295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864009296 S-adenosylmethionine binding site [chemical binding]; other site 1271864009297 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1271864009298 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1271864009299 ATP binding site [chemical binding]; other site 1271864009300 Mg++ binding site [ion binding]; other site 1271864009301 motif III; other site 1271864009302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864009303 nucleotide binding region [chemical binding]; other site 1271864009304 ATP-binding site [chemical binding]; other site 1271864009305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864009306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864009307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1271864009308 dimerization interface [polypeptide binding]; other site 1271864009309 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1271864009310 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1271864009311 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1271864009312 ligand binding site [chemical binding]; other site 1271864009313 active site 1271864009314 UGI interface [polypeptide binding]; other site 1271864009315 catalytic site [active] 1271864009316 putative methyltransferase; Provisional; Region: PRK10864 1271864009317 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1271864009318 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1271864009319 thioredoxin 2; Provisional; Region: PRK10996 1271864009320 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1271864009321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1271864009322 catalytic residues [active] 1271864009323 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1271864009324 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1271864009325 CoA binding domain; Region: CoA_binding_2; pfam13380 1271864009326 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1271864009327 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1271864009328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1271864009329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864009330 Coenzyme A binding pocket [chemical binding]; other site 1271864009331 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1271864009332 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1271864009333 domain interface [polypeptide binding]; other site 1271864009334 putative active site [active] 1271864009335 catalytic site [active] 1271864009336 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1271864009337 domain interface [polypeptide binding]; other site 1271864009338 putative active site [active] 1271864009339 catalytic site [active] 1271864009340 lipoprotein; Provisional; Region: PRK10759 1271864009341 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1271864009342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009343 putative substrate translocation pore; other site 1271864009344 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1271864009345 protein disaggregation chaperone; Provisional; Region: PRK10865 1271864009346 Clp amino terminal domain; Region: Clp_N; pfam02861 1271864009347 Clp amino terminal domain; Region: Clp_N; pfam02861 1271864009348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864009349 Walker A motif; other site 1271864009350 ATP binding site [chemical binding]; other site 1271864009351 Walker B motif; other site 1271864009352 arginine finger; other site 1271864009353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864009354 Walker A motif; other site 1271864009355 ATP binding site [chemical binding]; other site 1271864009356 Walker B motif; other site 1271864009357 arginine finger; other site 1271864009358 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1271864009359 hypothetical protein; Provisional; Region: PRK10723 1271864009360 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1271864009361 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1271864009362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864009363 RNA binding surface [nucleotide binding]; other site 1271864009364 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1271864009365 active site 1271864009366 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1271864009367 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1271864009368 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1271864009369 30S subunit binding site; other site 1271864009370 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1271864009371 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1271864009372 Prephenate dehydratase; Region: PDT; pfam00800 1271864009373 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1271864009374 putative L-Phe binding site [chemical binding]; other site 1271864009375 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1271864009376 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1271864009377 Chorismate mutase type II; Region: CM_2; cl00693 1271864009378 prephenate dehydrogenase; Validated; Region: PRK08507 1271864009379 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1271864009380 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1271864009381 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1271864009382 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1271864009383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864009384 metal binding site [ion binding]; metal-binding site 1271864009385 active site 1271864009386 I-site; other site 1271864009387 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1271864009388 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1271864009389 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1271864009390 RimM N-terminal domain; Region: RimM; pfam01782 1271864009391 PRC-barrel domain; Region: PRC; pfam05239 1271864009392 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1271864009393 signal recognition particle protein; Provisional; Region: PRK10867 1271864009394 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1271864009395 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1271864009396 P loop; other site 1271864009397 GTP binding site [chemical binding]; other site 1271864009398 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1271864009399 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1271864009400 hypothetical protein; Provisional; Region: PRK11573 1271864009401 Domain of unknown function DUF21; Region: DUF21; pfam01595 1271864009402 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1271864009403 Transporter associated domain; Region: CorC_HlyC; smart01091 1271864009404 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1271864009405 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1271864009406 dimer interface [polypeptide binding]; other site 1271864009407 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1271864009408 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1271864009409 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1271864009410 recombination and repair protein; Provisional; Region: PRK10869 1271864009411 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1271864009412 Walker A/P-loop; other site 1271864009413 ATP binding site [chemical binding]; other site 1271864009414 Q-loop/lid; other site 1271864009415 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1271864009416 ABC transporter signature motif; other site 1271864009417 Walker B; other site 1271864009418 D-loop; other site 1271864009419 H-loop/switch region; other site 1271864009420 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1271864009421 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1271864009422 hypothetical protein; Validated; Region: PRK01777 1271864009423 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1271864009424 putative coenzyme Q binding site [chemical binding]; other site 1271864009425 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1271864009426 SmpB-tmRNA interface; other site 1271864009427 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009428 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009429 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009430 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009431 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009432 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009433 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009434 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009435 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009436 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009437 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009438 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864009439 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009440 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009441 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1271864009442 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009443 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1271864009444 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1271864009445 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1271864009446 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1271864009447 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864009448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864009449 Walker A/P-loop; other site 1271864009450 ATP binding site [chemical binding]; other site 1271864009451 Q-loop/lid; other site 1271864009452 ABC transporter signature motif; other site 1271864009453 Walker B; other site 1271864009454 D-loop; other site 1271864009455 H-loop/switch region; other site 1271864009456 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1271864009457 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864009458 SEC-C motif; Region: SEC-C; pfam02810 1271864009459 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1271864009460 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 1271864009461 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1271864009462 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1271864009463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864009464 non-specific DNA binding site [nucleotide binding]; other site 1271864009465 salt bridge; other site 1271864009466 sequence-specific DNA binding site [nucleotide binding]; other site 1271864009467 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1271864009468 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 1271864009469 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 1271864009470 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1271864009471 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1271864009472 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1271864009473 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1271864009474 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1271864009475 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1271864009476 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1271864009477 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1271864009478 active site 1271864009479 dimer interface [polypeptide binding]; other site 1271864009480 magnesium binding site [ion binding]; other site 1271864009481 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1271864009482 tetramer interface [polypeptide binding]; other site 1271864009483 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1271864009484 active site 1271864009485 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 1271864009486 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 1271864009487 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1271864009488 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1271864009489 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1271864009490 active site turn [active] 1271864009491 phosphorylation site [posttranslational modification] 1271864009492 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1271864009493 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1271864009494 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1271864009495 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1271864009496 Integrase; Region: Integrase_1; pfam12835 1271864009497 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1271864009498 DNA-binding interface [nucleotide binding]; DNA binding site 1271864009499 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1271864009500 Family description; Region: UvrD_C_2; pfam13538 1271864009501 Transposase; Region: HTH_Tnp_1; cl17663 1271864009502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1271864009503 putative transposase OrfB; Reviewed; Region: PHA02517 1271864009504 HTH-like domain; Region: HTH_21; pfam13276 1271864009505 Integrase core domain; Region: rve; pfam00665 1271864009506 Integrase core domain; Region: rve_2; pfam13333 1271864009507 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 1271864009508 flagellin; Validated; Region: PRK08026 1271864009509 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1271864009510 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1271864009511 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1271864009512 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1271864009513 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1271864009514 homodimer interface [polypeptide binding]; other site 1271864009515 active site 1271864009516 TDP-binding site; other site 1271864009517 acceptor substrate-binding pocket; other site 1271864009518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864009519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864009520 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1271864009521 Walker A/P-loop; other site 1271864009522 ATP binding site [chemical binding]; other site 1271864009523 Q-loop/lid; other site 1271864009524 ABC transporter signature motif; other site 1271864009525 Walker B; other site 1271864009526 D-loop; other site 1271864009527 H-loop/switch region; other site 1271864009528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1271864009529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1271864009530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864009531 Walker A/P-loop; other site 1271864009532 ATP binding site [chemical binding]; other site 1271864009533 Q-loop/lid; other site 1271864009534 ABC transporter signature motif; other site 1271864009535 Walker B; other site 1271864009536 D-loop; other site 1271864009537 H-loop/switch region; other site 1271864009538 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1271864009539 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1271864009540 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1271864009541 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1271864009542 outer membrane receptor FepA; Provisional; Region: PRK13528 1271864009543 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864009544 N-terminal plug; other site 1271864009545 ligand-binding site [chemical binding]; other site 1271864009546 secreted effector protein PipB2; Provisional; Region: PRK15196 1271864009547 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864009548 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864009549 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864009550 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864009551 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1271864009552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1271864009553 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 1271864009554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1271864009555 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1271864009556 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1271864009557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1271864009558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1271864009559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864009560 dimer interface [polypeptide binding]; other site 1271864009561 phosphorylation site [posttranslational modification] 1271864009562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864009563 ATP binding site [chemical binding]; other site 1271864009564 Mg2+ binding site [ion binding]; other site 1271864009565 G-X-G motif; other site 1271864009566 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1271864009567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864009568 active site 1271864009569 phosphorylation site [posttranslational modification] 1271864009570 intermolecular recognition site; other site 1271864009571 dimerization interface [polypeptide binding]; other site 1271864009572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864009573 DNA binding site [nucleotide binding] 1271864009574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1271864009575 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1271864009576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1271864009577 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1271864009578 substrate binding pocket [chemical binding]; other site 1271864009579 active site 1271864009580 iron coordination sites [ion binding]; other site 1271864009581 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1271864009582 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1271864009583 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1271864009584 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1271864009585 tetramerization interface [polypeptide binding]; other site 1271864009586 NAD(P) binding site [chemical binding]; other site 1271864009587 catalytic residues [active] 1271864009588 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1271864009589 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1271864009590 inhibitor-cofactor binding pocket; inhibition site 1271864009591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864009592 catalytic residue [active] 1271864009593 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1271864009594 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1271864009595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864009596 DNA-binding site [nucleotide binding]; DNA binding site 1271864009597 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1271864009598 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1271864009599 bacterial OsmY and nodulation domain; Region: BON; smart00749 1271864009600 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864009601 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1271864009602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864009603 dimerization interface [polypeptide binding]; other site 1271864009604 putative DNA binding site [nucleotide binding]; other site 1271864009605 putative Zn2+ binding site [ion binding]; other site 1271864009606 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1271864009607 active site residue [active] 1271864009608 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1271864009609 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1271864009610 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1271864009611 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1271864009612 hypothetical protein; Provisional; Region: PRK10556 1271864009613 hypothetical protein; Provisional; Region: PRK10132 1271864009614 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1271864009615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864009616 DNA-binding site [nucleotide binding]; DNA binding site 1271864009617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864009618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864009619 homodimer interface [polypeptide binding]; other site 1271864009620 catalytic residue [active] 1271864009621 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1271864009622 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1271864009623 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1271864009624 catalytic residues [active] 1271864009625 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1271864009626 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1271864009627 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1271864009628 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1271864009629 active site 1271864009630 dimer interface [polypeptide binding]; other site 1271864009631 catalytic residues [active] 1271864009632 effector binding site; other site 1271864009633 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1271864009634 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1271864009635 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1271864009636 dimer interface [polypeptide binding]; other site 1271864009637 putative radical transfer pathway; other site 1271864009638 diiron center [ion binding]; other site 1271864009639 tyrosyl radical; other site 1271864009640 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1271864009641 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1271864009642 Walker A/P-loop; other site 1271864009643 ATP binding site [chemical binding]; other site 1271864009644 Q-loop/lid; other site 1271864009645 ABC transporter signature motif; other site 1271864009646 Walker B; other site 1271864009647 D-loop; other site 1271864009648 H-loop/switch region; other site 1271864009649 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1271864009650 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1271864009651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864009652 dimer interface [polypeptide binding]; other site 1271864009653 conserved gate region; other site 1271864009654 putative PBP binding loops; other site 1271864009655 ABC-ATPase subunit interface; other site 1271864009656 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1271864009657 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1271864009658 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1271864009659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009660 transcriptional repressor MprA; Provisional; Region: PRK10870 1271864009661 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1271864009662 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1271864009663 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864009664 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864009665 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1271864009666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009667 putative substrate translocation pore; other site 1271864009668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009669 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1271864009670 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1271864009671 glutamate--cysteine ligase; Provisional; Region: PRK02107 1271864009672 Predicted membrane protein [Function unknown]; Region: COG1238 1271864009673 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1271864009674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864009675 motif II; other site 1271864009676 carbon storage regulator; Provisional; Region: PRK01712 1271864009677 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1271864009678 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1271864009679 motif 1; other site 1271864009680 active site 1271864009681 motif 2; other site 1271864009682 motif 3; other site 1271864009683 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1271864009684 DHHA1 domain; Region: DHHA1; pfam02272 1271864009685 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1271864009686 recombinase A; Provisional; Region: recA; PRK09354 1271864009687 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1271864009688 hexamer interface [polypeptide binding]; other site 1271864009689 Walker A motif; other site 1271864009690 ATP binding site [chemical binding]; other site 1271864009691 Walker B motif; other site 1271864009692 hypothetical protein; Validated; Region: PRK03661 1271864009693 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1271864009694 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864009695 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864009696 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1271864009697 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1271864009698 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1271864009699 Nucleoside recognition; Region: Gate; pfam07670 1271864009700 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1271864009701 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1271864009702 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1271864009703 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1271864009704 putative NAD(P) binding site [chemical binding]; other site 1271864009705 active site 1271864009706 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1271864009707 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1271864009708 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1271864009709 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864009710 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1271864009711 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1271864009712 putative active site [active] 1271864009713 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1271864009714 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1271864009715 GAF domain; Region: GAF; pfam01590 1271864009716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864009717 Walker A motif; other site 1271864009718 ATP binding site [chemical binding]; other site 1271864009719 Walker B motif; other site 1271864009720 arginine finger; other site 1271864009721 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1271864009722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1271864009723 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1271864009724 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1271864009725 iron binding site [ion binding]; other site 1271864009726 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1271864009727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864009728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864009729 Acylphosphatase; Region: Acylphosphatase; pfam00708 1271864009730 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1271864009731 HypF finger; Region: zf-HYPF; pfam07503 1271864009732 HypF finger; Region: zf-HYPF; pfam07503 1271864009733 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1271864009734 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1271864009735 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1271864009736 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1271864009737 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1271864009738 nickel binding site [ion binding]; other site 1271864009739 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1271864009740 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1271864009741 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1271864009742 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1271864009743 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1271864009744 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1271864009745 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1271864009746 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1271864009747 NADH dehydrogenase; Region: NADHdh; cl00469 1271864009748 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1271864009749 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1271864009750 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1271864009751 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1271864009752 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1271864009753 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1271864009754 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1271864009755 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1271864009756 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1271864009757 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1271864009758 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1271864009759 dimerization interface [polypeptide binding]; other site 1271864009760 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1271864009761 ATP binding site [chemical binding]; other site 1271864009762 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1271864009763 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1271864009764 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1271864009765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864009766 Walker A motif; other site 1271864009767 ATP binding site [chemical binding]; other site 1271864009768 Walker B motif; other site 1271864009769 arginine finger; other site 1271864009770 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1271864009771 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1271864009772 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1271864009773 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1271864009774 metal binding site [ion binding]; metal-binding site 1271864009775 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1271864009776 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1271864009777 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1271864009778 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864009779 ABC-ATPase subunit interface; other site 1271864009780 dimer interface [polypeptide binding]; other site 1271864009781 putative PBP binding regions; other site 1271864009782 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1271864009783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1271864009784 ABC-ATPase subunit interface; other site 1271864009785 dimer interface [polypeptide binding]; other site 1271864009786 putative PBP binding regions; other site 1271864009787 effector protein YopJ; Provisional; Region: PRK15371 1271864009788 transcriptional activator SprB; Provisional; Region: PRK15320 1271864009789 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1271864009790 transcriptional regulator SirC; Provisional; Region: PRK15044 1271864009791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864009792 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 1271864009793 invasion protein OrgB; Provisional; Region: PRK15322 1271864009794 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 1271864009795 invasion protein OrgA; Provisional; Region: PRK15323 1271864009796 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 1271864009797 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1271864009798 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 1271864009799 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 1271864009800 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1271864009801 transcriptional regulator HilD; Provisional; Region: PRK15185 1271864009802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864009803 invasion protein regulator; Provisional; Region: PRK12370 1271864009804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864009805 DNA binding site [nucleotide binding] 1271864009806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1271864009807 binding surface 1271864009808 TPR motif; other site 1271864009809 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1271864009810 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864009811 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864009812 catalytic residue [active] 1271864009813 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 1271864009814 active site 1271864009815 chaperone protein SicP; Provisional; Region: PRK15329 1271864009816 putative acyl carrier protein IacP; Validated; Region: PRK08172 1271864009817 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 1271864009818 cell invasion protein SipD; Provisional; Region: PRK15330 1271864009819 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 1271864009820 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1271864009821 chaperone protein SicA; Provisional; Region: PRK15331 1271864009822 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1271864009823 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1271864009824 type III secretion system protein SpaS; Validated; Region: PRK08156 1271864009825 type III secretion system protein SpaR; Provisional; Region: PRK15332 1271864009826 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1271864009827 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1271864009828 type III secretion system protein SpaO; Validated; Region: PRK08158 1271864009829 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1271864009830 antigen presentation protein SpaN; Provisional; Region: PRK15334 1271864009831 Surface presentation of antigens protein; Region: SPAN; pfam02510 1271864009832 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 1271864009833 ATP synthase SpaL; Validated; Region: PRK08149 1271864009834 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1271864009835 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1271864009836 Walker A motif; other site 1271864009837 ATP binding site [chemical binding]; other site 1271864009838 Walker B motif; other site 1271864009839 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 1271864009840 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1271864009841 type III secretion system protein InvA; Provisional; Region: PRK15337 1271864009842 type III secretion system regulator InvE; Provisional; Region: PRK15338 1271864009843 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1271864009844 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1271864009845 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1271864009846 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1271864009847 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1271864009848 transcriptional regulator InvF; Provisional; Region: PRK15340 1271864009849 InvH outer membrane lipoprotein; Region: InvH; pfam04741 1271864009850 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1271864009851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1271864009852 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1271864009853 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1271864009854 active site 1271864009855 metal binding site [ion binding]; metal-binding site 1271864009856 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1271864009857 MutS domain I; Region: MutS_I; pfam01624 1271864009858 MutS domain II; Region: MutS_II; pfam05188 1271864009859 MutS domain III; Region: MutS_III; pfam05192 1271864009860 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1271864009861 Walker A/P-loop; other site 1271864009862 ATP binding site [chemical binding]; other site 1271864009863 Q-loop/lid; other site 1271864009864 ABC transporter signature motif; other site 1271864009865 Walker B; other site 1271864009866 D-loop; other site 1271864009867 H-loop/switch region; other site 1271864009868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1271864009869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864009870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1271864009871 putative substrate translocation pore; other site 1271864009872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864009873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864009874 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1271864009875 putative effector binding pocket; other site 1271864009876 dimerization interface [polypeptide binding]; other site 1271864009877 GntP family permease; Region: GntP_permease; pfam02447 1271864009878 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1271864009879 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1271864009880 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1271864009881 putative NAD(P) binding site [chemical binding]; other site 1271864009882 active site 1271864009883 putative substrate binding site [chemical binding]; other site 1271864009884 hypothetical protein; Provisional; Region: PRK09989 1271864009885 putative aldolase; Validated; Region: PRK08130 1271864009886 intersubunit interface [polypeptide binding]; other site 1271864009887 active site 1271864009888 Zn2+ binding site [ion binding]; other site 1271864009889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1271864009890 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1271864009891 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1271864009892 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864009893 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1271864009894 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864009895 MarR family; Region: MarR_2; cl17246 1271864009896 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1271864009897 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1271864009898 Flavoprotein; Region: Flavoprotein; pfam02441 1271864009899 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1271864009900 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1271864009901 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1271864009902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1271864009903 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1271864009904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1271864009905 DNA binding residues [nucleotide binding] 1271864009906 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1271864009907 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864009908 Peptidase family M23; Region: Peptidase_M23; pfam01551 1271864009909 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1271864009910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864009911 S-adenosylmethionine binding site [chemical binding]; other site 1271864009912 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1271864009913 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1271864009914 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1271864009915 Permutation of conserved domain; other site 1271864009916 active site 1271864009917 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1271864009918 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1271864009919 homotrimer interaction site [polypeptide binding]; other site 1271864009920 zinc binding site [ion binding]; other site 1271864009921 CDP-binding sites; other site 1271864009922 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1271864009923 substrate binding site; other site 1271864009924 dimer interface; other site 1271864009925 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1271864009926 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1271864009927 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1271864009928 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1271864009929 ligand-binding site [chemical binding]; other site 1271864009930 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1271864009931 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1271864009932 CysD dimerization site [polypeptide binding]; other site 1271864009933 G1 box; other site 1271864009934 putative GEF interaction site [polypeptide binding]; other site 1271864009935 GTP/Mg2+ binding site [chemical binding]; other site 1271864009936 Switch I region; other site 1271864009937 G2 box; other site 1271864009938 G3 box; other site 1271864009939 Switch II region; other site 1271864009940 G4 box; other site 1271864009941 G5 box; other site 1271864009942 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1271864009943 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1271864009944 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1271864009945 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1271864009946 Active Sites [active] 1271864009947 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1271864009948 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1271864009949 metal binding site [ion binding]; metal-binding site 1271864009950 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1271864009951 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1271864009952 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1271864009953 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1271864009954 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1271864009955 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1271864009956 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1271864009957 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1271864009958 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1271864009959 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1271864009960 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1271864009961 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 1271864009962 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1271864009963 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1271864009964 Active Sites [active] 1271864009965 sulfite reductase subunit beta; Provisional; Region: PRK13504 1271864009966 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1271864009967 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1271864009968 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1271864009969 Flavodoxin; Region: Flavodoxin_1; pfam00258 1271864009970 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1271864009971 FAD binding pocket [chemical binding]; other site 1271864009972 FAD binding motif [chemical binding]; other site 1271864009973 catalytic residues [active] 1271864009974 NAD binding pocket [chemical binding]; other site 1271864009975 phosphate binding motif [ion binding]; other site 1271864009976 beta-alpha-beta structure motif; other site 1271864009977 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1271864009978 active site 1271864009979 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1271864009980 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1271864009981 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1271864009982 enolase; Provisional; Region: eno; PRK00077 1271864009983 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1271864009984 dimer interface [polypeptide binding]; other site 1271864009985 metal binding site [ion binding]; metal-binding site 1271864009986 substrate binding pocket [chemical binding]; other site 1271864009987 CTP synthetase; Validated; Region: pyrG; PRK05380 1271864009988 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1271864009989 Catalytic site [active] 1271864009990 active site 1271864009991 UTP binding site [chemical binding]; other site 1271864009992 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1271864009993 active site 1271864009994 putative oxyanion hole; other site 1271864009995 catalytic triad [active] 1271864009996 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1271864009997 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1271864009998 homodimer interface [polypeptide binding]; other site 1271864009999 metal binding site [ion binding]; metal-binding site 1271864010000 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1271864010001 homodimer interface [polypeptide binding]; other site 1271864010002 active site 1271864010003 putative chemical substrate binding site [chemical binding]; other site 1271864010004 metal binding site [ion binding]; metal-binding site 1271864010005 fimbrial protein SteA; Provisional; Region: PRK15261 1271864010006 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 1271864010007 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864010008 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864010009 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864010010 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 1271864010011 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864010012 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864010013 putative fimbrial protein SteD; Provisional; Region: PRK15275 1271864010014 putative fimbrial subunit SteE; Provisional; Region: PRK15276 1271864010015 fimbrial protein SteF; Provisional; Region: PRK15260 1271864010016 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1271864010017 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1271864010018 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1271864010019 HD domain; Region: HD_4; pfam13328 1271864010020 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1271864010021 synthetase active site [active] 1271864010022 NTP binding site [chemical binding]; other site 1271864010023 metal binding site [ion binding]; metal-binding site 1271864010024 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1271864010025 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1271864010026 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1271864010027 TRAM domain; Region: TRAM; pfam01938 1271864010028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864010029 S-adenosylmethionine binding site [chemical binding]; other site 1271864010030 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1271864010031 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1271864010032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864010033 dimerization interface [polypeptide binding]; other site 1271864010034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864010035 dimer interface [polypeptide binding]; other site 1271864010036 phosphorylation site [posttranslational modification] 1271864010037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864010038 ATP binding site [chemical binding]; other site 1271864010039 Mg2+ binding site [ion binding]; other site 1271864010040 G-X-G motif; other site 1271864010041 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1271864010042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864010043 active site 1271864010044 phosphorylation site [posttranslational modification] 1271864010045 intermolecular recognition site; other site 1271864010046 dimerization interface [polypeptide binding]; other site 1271864010047 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1271864010048 putative binding surface; other site 1271864010049 active site 1271864010050 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1271864010051 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1271864010052 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1271864010053 active site 1271864010054 tetramer interface [polypeptide binding]; other site 1271864010055 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1271864010056 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1271864010057 active site 1271864010058 tetramer interface [polypeptide binding]; other site 1271864010059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010060 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864010061 putative substrate translocation pore; other site 1271864010062 flavodoxin; Provisional; Region: PRK08105 1271864010063 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1271864010064 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1271864010065 probable active site [active] 1271864010066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1271864010067 SecY interacting protein Syd; Provisional; Region: PRK04968 1271864010068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1271864010069 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1271864010070 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1271864010071 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1271864010072 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1271864010073 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1271864010074 serine transporter; Region: stp; TIGR00814 1271864010075 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1271864010076 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1271864010077 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1271864010078 flap endonuclease-like protein; Provisional; Region: PRK09482 1271864010079 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1271864010080 active site 1271864010081 metal binding site 1 [ion binding]; metal-binding site 1271864010082 putative 5' ssDNA interaction site; other site 1271864010083 metal binding site 3; metal-binding site 1271864010084 metal binding site 2 [ion binding]; metal-binding site 1271864010085 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1271864010086 putative DNA binding site [nucleotide binding]; other site 1271864010087 putative metal binding site [ion binding]; other site 1271864010088 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1271864010089 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1271864010090 dimer interface [polypeptide binding]; other site 1271864010091 active site 1271864010092 metal binding site [ion binding]; metal-binding site 1271864010093 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1271864010094 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1271864010095 intersubunit interface [polypeptide binding]; other site 1271864010096 active site 1271864010097 Zn2+ binding site [ion binding]; other site 1271864010098 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1271864010099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010100 putative substrate translocation pore; other site 1271864010101 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1271864010102 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1271864010103 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1271864010104 trimer interface [polypeptide binding]; other site 1271864010105 substrate binding site [chemical binding]; other site 1271864010106 Mn binding site [ion binding]; other site 1271864010107 L-fuculokinase; Provisional; Region: PRK10331 1271864010108 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1271864010109 nucleotide binding site [chemical binding]; other site 1271864010110 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1271864010111 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1271864010112 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1271864010113 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864010114 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1271864010115 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1271864010116 hypothetical protein; Provisional; Region: PRK10873 1271864010117 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1271864010118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864010119 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1271864010120 dimerization interface [polypeptide binding]; other site 1271864010121 substrate binding pocket [chemical binding]; other site 1271864010122 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1271864010123 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1271864010124 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1271864010125 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864010126 catalytic residue [active] 1271864010127 CsdA-binding activator; Provisional; Region: PRK15019 1271864010128 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1271864010129 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1271864010130 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1271864010131 putative ATP binding site [chemical binding]; other site 1271864010132 putative substrate interface [chemical binding]; other site 1271864010133 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1271864010134 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1271864010135 MltA specific insert domain; Region: MltA; pfam03562 1271864010136 3D domain; Region: 3D; pfam06725 1271864010137 AMIN domain; Region: AMIN; pfam11741 1271864010138 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1271864010139 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1271864010140 active site 1271864010141 metal binding site [ion binding]; metal-binding site 1271864010142 N-acetylglutamate synthase; Validated; Region: PRK05279 1271864010143 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1271864010144 putative feedback inhibition sensing region; other site 1271864010145 putative nucleotide binding site [chemical binding]; other site 1271864010146 putative substrate binding site [chemical binding]; other site 1271864010147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864010148 Coenzyme A binding pocket [chemical binding]; other site 1271864010149 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1271864010150 AAA domain; Region: AAA_30; pfam13604 1271864010151 Family description; Region: UvrD_C_2; pfam13538 1271864010152 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1271864010153 protease3; Provisional; Region: PRK15101 1271864010154 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1271864010155 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1271864010156 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1271864010157 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1271864010158 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1271864010159 hypothetical protein; Provisional; Region: PRK10332 1271864010160 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1271864010161 hypothetical protein; Provisional; Region: PRK11521 1271864010162 hypothetical protein; Provisional; Region: PRK10557 1271864010163 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1271864010164 hypothetical protein; Provisional; Region: PRK10506 1271864010165 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1271864010166 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1271864010167 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1271864010168 dimerization interface [polypeptide binding]; other site 1271864010169 active site 1271864010170 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1271864010171 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1271864010172 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1271864010173 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1271864010174 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1271864010175 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1271864010176 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1271864010177 putative active site [active] 1271864010178 Ap4A binding site [chemical binding]; other site 1271864010179 nudix motif; other site 1271864010180 putative metal binding site [ion binding]; other site 1271864010181 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1271864010182 putative DNA-binding cleft [nucleotide binding]; other site 1271864010183 putative DNA clevage site; other site 1271864010184 molecular lever; other site 1271864010185 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1271864010186 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1271864010187 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864010188 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864010189 active site 1271864010190 catalytic tetrad [active] 1271864010191 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1271864010192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010193 putative substrate translocation pore; other site 1271864010194 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1271864010195 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1271864010196 putative acyl-acceptor binding pocket; other site 1271864010197 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1271864010198 acyl-activating enzyme (AAE) consensus motif; other site 1271864010199 putative AMP binding site [chemical binding]; other site 1271864010200 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1271864010201 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864010202 DNA binding site [nucleotide binding] 1271864010203 domain linker motif; other site 1271864010204 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1271864010205 dimerization interface (closed form) [polypeptide binding]; other site 1271864010206 ligand binding site [chemical binding]; other site 1271864010207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1271864010208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864010209 DNA binding site [nucleotide binding] 1271864010210 domain linker motif; other site 1271864010211 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1271864010212 dimerization interface (closed form) [polypeptide binding]; other site 1271864010213 ligand binding site [chemical binding]; other site 1271864010214 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1271864010215 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1271864010216 active site 1271864010217 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1271864010218 substrate binding site [chemical binding]; other site 1271864010219 catalytic residues [active] 1271864010220 dimer interface [polypeptide binding]; other site 1271864010221 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1271864010222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864010223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864010224 dimerization interface [polypeptide binding]; other site 1271864010225 putative racemase; Provisional; Region: PRK10200 1271864010226 aspartate racemase; Region: asp_race; TIGR00035 1271864010227 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1271864010228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010229 putative substrate translocation pore; other site 1271864010230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010231 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1271864010232 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1271864010233 NADP binding site [chemical binding]; other site 1271864010234 homodimer interface [polypeptide binding]; other site 1271864010235 active site 1271864010236 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1271864010237 putative acyltransferase; Provisional; Region: PRK05790 1271864010238 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1271864010239 dimer interface [polypeptide binding]; other site 1271864010240 active site 1271864010241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864010242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864010243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1271864010244 dimerization interface [polypeptide binding]; other site 1271864010245 Predicted membrane protein [Function unknown]; Region: COG4125 1271864010246 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1271864010247 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1271864010248 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1271864010249 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1271864010250 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1271864010251 putative metal binding site [ion binding]; other site 1271864010252 putative homodimer interface [polypeptide binding]; other site 1271864010253 putative homotetramer interface [polypeptide binding]; other site 1271864010254 putative homodimer-homodimer interface [polypeptide binding]; other site 1271864010255 putative allosteric switch controlling residues; other site 1271864010256 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1271864010257 transcriptional activator SprB; Provisional; Region: PRK15320 1271864010258 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 1271864010259 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 1271864010260 Fimbrial protein; Region: Fimbrial; pfam00419 1271864010261 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1271864010262 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864010263 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864010264 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 1271864010265 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864010266 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864010267 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864010268 fimbrial protein StdA; Provisional; Region: PRK15210 1271864010269 hypothetical protein; Provisional; Region: PRK10316 1271864010270 YfdX protein; Region: YfdX; pfam10938 1271864010271 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1271864010272 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1271864010273 tetramer interface [polypeptide binding]; other site 1271864010274 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1271864010275 active site 1271864010276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1271864010277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1271864010278 NAD(P) binding site [chemical binding]; other site 1271864010279 active site 1271864010280 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1271864010281 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1271864010282 substrate binding site [chemical binding]; other site 1271864010283 hexamer interface [polypeptide binding]; other site 1271864010284 metal binding site [ion binding]; metal-binding site 1271864010285 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1271864010286 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1271864010287 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1271864010288 active site 1271864010289 P-loop; other site 1271864010290 phosphorylation site [posttranslational modification] 1271864010291 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864010292 active site 1271864010293 phosphorylation site [posttranslational modification] 1271864010294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864010295 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1271864010296 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864010297 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1271864010298 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1271864010299 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1271864010300 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1271864010301 active site 1271864010302 P-loop; other site 1271864010303 phosphorylation site [posttranslational modification] 1271864010304 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864010305 active site 1271864010306 phosphorylation site [posttranslational modification] 1271864010307 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1271864010308 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1271864010309 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1271864010310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864010311 dimerization interface [polypeptide binding]; other site 1271864010312 putative DNA binding site [nucleotide binding]; other site 1271864010313 putative Zn2+ binding site [ion binding]; other site 1271864010314 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1271864010315 active site 1271864010316 Int/Topo IB signature motif; other site 1271864010317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1271864010318 Peptidase family M23; Region: Peptidase_M23; pfam01551 1271864010319 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1271864010320 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1271864010321 active site 1271864010322 metal binding site [ion binding]; metal-binding site 1271864010323 nudix motif; other site 1271864010324 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1271864010325 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1271864010326 dimer interface [polypeptide binding]; other site 1271864010327 putative anticodon binding site; other site 1271864010328 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1271864010329 motif 1; other site 1271864010330 active site 1271864010331 motif 2; other site 1271864010332 motif 3; other site 1271864010333 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1271864010334 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1271864010335 RF-1 domain; Region: RF-1; pfam00472 1271864010336 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1271864010337 DHH family; Region: DHH; pfam01368 1271864010338 DHHA1 domain; Region: DHHA1; pfam02272 1271864010339 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1271864010340 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1271864010341 dimerization domain [polypeptide binding]; other site 1271864010342 dimer interface [polypeptide binding]; other site 1271864010343 catalytic residues [active] 1271864010344 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1271864010345 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1271864010346 active site 1271864010347 Int/Topo IB signature motif; other site 1271864010348 flavodoxin FldB; Provisional; Region: PRK12359 1271864010349 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1271864010350 hypothetical protein; Provisional; Region: PRK10878 1271864010351 putative global regulator; Reviewed; Region: PRK09559 1271864010352 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1271864010353 hemolysin; Provisional; Region: PRK15087 1271864010354 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1271864010355 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1271864010356 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1271864010357 beta-galactosidase; Region: BGL; TIGR03356 1271864010358 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1271864010359 glycine dehydrogenase; Provisional; Region: PRK05367 1271864010360 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1271864010361 tetramer interface [polypeptide binding]; other site 1271864010362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864010363 catalytic residue [active] 1271864010364 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1271864010365 tetramer interface [polypeptide binding]; other site 1271864010366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864010367 catalytic residue [active] 1271864010368 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1271864010369 lipoyl attachment site [posttranslational modification]; other site 1271864010370 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1271864010371 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1271864010372 oxidoreductase; Provisional; Region: PRK08013 1271864010373 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1271864010374 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1271864010375 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1271864010376 proline aminopeptidase P II; Provisional; Region: PRK10879 1271864010377 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1271864010378 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1271864010379 active site 1271864010380 hypothetical protein; Reviewed; Region: PRK01736 1271864010381 Z-ring-associated protein; Provisional; Region: PRK10972 1271864010382 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1271864010383 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1271864010384 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1271864010385 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1271864010386 ligand binding site [chemical binding]; other site 1271864010387 NAD binding site [chemical binding]; other site 1271864010388 tetramer interface [polypeptide binding]; other site 1271864010389 catalytic site [active] 1271864010390 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1271864010391 L-serine binding site [chemical binding]; other site 1271864010392 ACT domain interface; other site 1271864010393 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1271864010394 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1271864010395 active site 1271864010396 dimer interface [polypeptide binding]; other site 1271864010397 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1271864010398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864010399 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1271864010400 putative dimerization interface [polypeptide binding]; other site 1271864010401 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1271864010402 oxidative stress defense protein; Provisional; Region: PRK11087 1271864010403 arginine exporter protein; Provisional; Region: PRK09304 1271864010404 mechanosensitive channel MscS; Provisional; Region: PRK10334 1271864010405 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864010406 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1271864010407 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1271864010408 active site 1271864010409 intersubunit interface [polypeptide binding]; other site 1271864010410 zinc binding site [ion binding]; other site 1271864010411 Na+ binding site [ion binding]; other site 1271864010412 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1271864010413 Phosphoglycerate kinase; Region: PGK; pfam00162 1271864010414 substrate binding site [chemical binding]; other site 1271864010415 hinge regions; other site 1271864010416 ADP binding site [chemical binding]; other site 1271864010417 catalytic site [active] 1271864010418 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1271864010419 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1271864010420 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1271864010421 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1271864010422 trimer interface [polypeptide binding]; other site 1271864010423 putative Zn binding site [ion binding]; other site 1271864010424 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1271864010425 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1271864010426 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1271864010427 Walker A/P-loop; other site 1271864010428 ATP binding site [chemical binding]; other site 1271864010429 Q-loop/lid; other site 1271864010430 ABC transporter signature motif; other site 1271864010431 Walker B; other site 1271864010432 D-loop; other site 1271864010433 H-loop/switch region; other site 1271864010434 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1271864010435 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1271864010436 Walker A/P-loop; other site 1271864010437 ATP binding site [chemical binding]; other site 1271864010438 Q-loop/lid; other site 1271864010439 ABC transporter signature motif; other site 1271864010440 Walker B; other site 1271864010441 D-loop; other site 1271864010442 H-loop/switch region; other site 1271864010443 transketolase; Reviewed; Region: PRK12753 1271864010444 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1271864010445 TPP-binding site [chemical binding]; other site 1271864010446 dimer interface [polypeptide binding]; other site 1271864010447 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1271864010448 PYR/PP interface [polypeptide binding]; other site 1271864010449 dimer interface [polypeptide binding]; other site 1271864010450 TPP binding site [chemical binding]; other site 1271864010451 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1271864010452 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1271864010453 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1271864010454 agmatinase; Region: agmatinase; TIGR01230 1271864010455 oligomer interface [polypeptide binding]; other site 1271864010456 putative active site [active] 1271864010457 Mn binding site [ion binding]; other site 1271864010458 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1271864010459 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1271864010460 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1271864010461 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1271864010462 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1271864010463 putative NAD(P) binding site [chemical binding]; other site 1271864010464 catalytic Zn binding site [ion binding]; other site 1271864010465 structural Zn binding site [ion binding]; other site 1271864010466 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1271864010467 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1271864010468 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1271864010469 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1271864010470 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1271864010471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864010472 DNA-binding site [nucleotide binding]; DNA binding site 1271864010473 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1271864010474 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1271864010475 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1271864010476 dimer interface [polypeptide binding]; other site 1271864010477 active site 1271864010478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1271864010479 catalytic residues [active] 1271864010480 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1271864010481 Virulence promoting factor; Region: YqgB; pfam11036 1271864010482 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1271864010483 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1271864010484 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1271864010485 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1271864010486 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1271864010487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010488 putative substrate translocation pore; other site 1271864010489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010490 hypothetical protein; Provisional; Region: PRK04860 1271864010491 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1271864010492 DNA-specific endonuclease I; Provisional; Region: PRK15137 1271864010493 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1271864010494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1271864010495 RNA methyltransferase, RsmE family; Region: TIGR00046 1271864010496 glutathione synthetase; Provisional; Region: PRK05246 1271864010497 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1271864010498 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1271864010499 hypothetical protein; Validated; Region: PRK00228 1271864010500 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1271864010501 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1271864010502 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1271864010503 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1271864010504 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1271864010505 Walker A motif; other site 1271864010506 ATP binding site [chemical binding]; other site 1271864010507 Walker B motif; other site 1271864010508 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1271864010509 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1271864010510 catalytic residue [active] 1271864010511 YGGT family; Region: YGGT; pfam02325 1271864010512 YGGT family; Region: YGGT; pfam02325 1271864010513 hypothetical protein; Validated; Region: PRK05090 1271864010514 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1271864010515 active site 1271864010516 dimerization interface [polypeptide binding]; other site 1271864010517 HemN family oxidoreductase; Provisional; Region: PRK05660 1271864010518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864010519 FeS/SAM binding site; other site 1271864010520 HemN C-terminal domain; Region: HemN_C; pfam06969 1271864010521 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1271864010522 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1271864010523 homodimer interface [polypeptide binding]; other site 1271864010524 active site 1271864010525 hypothetical protein; Provisional; Region: PRK10626 1271864010526 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1271864010527 hypothetical protein; Provisional; Region: PRK11702 1271864010528 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1271864010529 adenine DNA glycosylase; Provisional; Region: PRK10880 1271864010530 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1271864010531 minor groove reading motif; other site 1271864010532 helix-hairpin-helix signature motif; other site 1271864010533 substrate binding pocket [chemical binding]; other site 1271864010534 active site 1271864010535 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1271864010536 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1271864010537 DNA binding and oxoG recognition site [nucleotide binding] 1271864010538 oxidative damage protection protein; Provisional; Region: PRK05408 1271864010539 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1271864010540 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1271864010541 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864010542 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864010543 catalytic residue [active] 1271864010544 nucleoside transporter; Region: 2A0110; TIGR00889 1271864010545 ornithine decarboxylase; Provisional; Region: PRK13578 1271864010546 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1271864010547 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1271864010548 homodimer interface [polypeptide binding]; other site 1271864010549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864010550 catalytic residue [active] 1271864010551 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1271864010552 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1271864010553 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1271864010554 dimer interface [polypeptide binding]; other site 1271864010555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1271864010556 metal binding site [ion binding]; metal-binding site 1271864010557 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1271864010558 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1271864010559 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1271864010560 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1271864010561 putative active site [active] 1271864010562 putative catalytic site [active] 1271864010563 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1271864010564 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1271864010565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864010566 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1271864010567 putative dimerization interface [polypeptide binding]; other site 1271864010568 putative substrate binding pocket [chemical binding]; other site 1271864010569 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1271864010570 Sulfatase; Region: Sulfatase; pfam00884 1271864010571 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1271864010572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864010573 FeS/SAM binding site; other site 1271864010574 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1271864010575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1271864010576 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864010577 DNA binding residues [nucleotide binding] 1271864010578 dimerization interface [polypeptide binding]; other site 1271864010579 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1271864010580 Amino acid permease; Region: AA_permease_2; pfam13520 1271864010581 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1271864010582 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1271864010583 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1271864010584 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 1271864010585 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1271864010586 NAD(P) binding site [chemical binding]; other site 1271864010587 catalytic residues [active] 1271864010588 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1271864010589 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1271864010590 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1271864010591 active site 1271864010592 catalytic site [active] 1271864010593 Zn binding site [ion binding]; other site 1271864010594 tetramer interface [polypeptide binding]; other site 1271864010595 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1271864010596 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1271864010597 putative active site [active] 1271864010598 catalytic triad [active] 1271864010599 putative dimer interface [polypeptide binding]; other site 1271864010600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864010601 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864010602 putative substrate translocation pore; other site 1271864010603 mannonate dehydratase; Provisional; Region: PRK03906 1271864010604 mannonate dehydratase; Region: uxuA; TIGR00695 1271864010605 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1271864010606 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1271864010607 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1271864010608 Glucuronate isomerase; Region: UxaC; pfam02614 1271864010609 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1271864010610 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864010611 dimer interface [polypeptide binding]; other site 1271864010612 putative CheW interface [polypeptide binding]; other site 1271864010613 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1271864010614 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1271864010615 CHAP domain; Region: CHAP; pfam05257 1271864010616 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1271864010617 putative S-transferase; Provisional; Region: PRK11752 1271864010618 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1271864010619 C-terminal domain interface [polypeptide binding]; other site 1271864010620 GSH binding site (G-site) [chemical binding]; other site 1271864010621 dimer interface [polypeptide binding]; other site 1271864010622 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1271864010623 dimer interface [polypeptide binding]; other site 1271864010624 N-terminal domain interface [polypeptide binding]; other site 1271864010625 active site 1271864010626 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1271864010627 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1271864010628 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1271864010629 putative ligand binding residues [chemical binding]; other site 1271864010630 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1271864010631 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1271864010632 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1271864010633 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1271864010634 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1271864010635 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1271864010636 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1271864010637 putative substrate-binding site; other site 1271864010638 nickel binding site [ion binding]; other site 1271864010639 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1271864010640 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1271864010641 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1271864010642 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1271864010643 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1271864010644 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1271864010645 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1271864010646 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1271864010647 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1271864010648 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1271864010649 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1271864010650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864010651 dimerization interface [polypeptide binding]; other site 1271864010652 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864010653 dimer interface [polypeptide binding]; other site 1271864010654 putative CheW interface [polypeptide binding]; other site 1271864010655 hypothetical protein; Provisional; Region: PRK05208 1271864010656 oxidoreductase; Provisional; Region: PRK07985 1271864010657 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1271864010658 NAD binding site [chemical binding]; other site 1271864010659 metal binding site [ion binding]; metal-binding site 1271864010660 active site 1271864010661 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1271864010662 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1271864010663 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1271864010664 cystathionine beta-lyase; Provisional; Region: PRK08114 1271864010665 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1271864010666 homodimer interface [polypeptide binding]; other site 1271864010667 substrate-cofactor binding pocket; other site 1271864010668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864010669 catalytic residue [active] 1271864010670 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1271864010671 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1271864010672 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1271864010673 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1271864010674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864010675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864010676 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1271864010677 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1271864010678 dimer interface [polypeptide binding]; other site 1271864010679 active site 1271864010680 metal binding site [ion binding]; metal-binding site 1271864010681 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1271864010682 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1271864010683 active site 1271864010684 catalytic tetrad [active] 1271864010685 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1271864010686 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1271864010687 transmembrane helices; other site 1271864010688 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1271864010689 nucleotide binding site/active site [active] 1271864010690 catalytic residue [active] 1271864010691 hypothetical protein; Provisional; Region: PRK01254 1271864010692 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1271864010693 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1271864010694 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1271864010695 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1271864010696 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1271864010697 DctM-like transporters; Region: DctM; pfam06808 1271864010698 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1271864010699 FtsI repressor; Provisional; Region: PRK10883 1271864010700 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1271864010701 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1271864010702 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1271864010703 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1271864010704 putative acyl-acceptor binding pocket; other site 1271864010705 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1271864010706 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1271864010707 CAP-like domain; other site 1271864010708 active site 1271864010709 primary dimer interface [polypeptide binding]; other site 1271864010710 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1271864010711 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864010712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864010713 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1271864010714 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1271864010715 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1271864010716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864010717 active site 1271864010718 phosphorylation site [posttranslational modification] 1271864010719 intermolecular recognition site; other site 1271864010720 dimerization interface [polypeptide binding]; other site 1271864010721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864010722 DNA binding site [nucleotide binding] 1271864010723 sensor protein QseC; Provisional; Region: PRK10337 1271864010724 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1271864010725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864010726 dimer interface [polypeptide binding]; other site 1271864010727 phosphorylation site [posttranslational modification] 1271864010728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864010729 ATP binding site [chemical binding]; other site 1271864010730 Mg2+ binding site [ion binding]; other site 1271864010731 G-X-G motif; other site 1271864010732 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1271864010733 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1271864010734 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1271864010735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864010736 ATP binding site [chemical binding]; other site 1271864010737 Mg2+ binding site [ion binding]; other site 1271864010738 G-X-G motif; other site 1271864010739 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1271864010740 anchoring element; other site 1271864010741 dimer interface [polypeptide binding]; other site 1271864010742 ATP binding site [chemical binding]; other site 1271864010743 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1271864010744 active site 1271864010745 metal binding site [ion binding]; metal-binding site 1271864010746 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1271864010747 esterase YqiA; Provisional; Region: PRK11071 1271864010748 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1271864010749 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1271864010750 active site 1271864010751 metal binding site [ion binding]; metal-binding site 1271864010752 hexamer interface [polypeptide binding]; other site 1271864010753 putative dehydrogenase; Provisional; Region: PRK11039 1271864010754 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1271864010755 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1271864010756 dimer interface [polypeptide binding]; other site 1271864010757 ADP-ribose binding site [chemical binding]; other site 1271864010758 active site 1271864010759 nudix motif; other site 1271864010760 metal binding site [ion binding]; metal-binding site 1271864010761 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1271864010762 hypothetical protein; Provisional; Region: PRK11653 1271864010763 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1271864010764 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1271864010765 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1271864010766 putative active site [active] 1271864010767 metal binding site [ion binding]; metal-binding site 1271864010768 zinc transporter ZupT; Provisional; Region: PRK04201 1271864010769 ZIP Zinc transporter; Region: Zip; pfam02535 1271864010770 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1271864010771 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1271864010772 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1271864010773 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1271864010774 catalytic residues [active] 1271864010775 hinge region; other site 1271864010776 alpha helical domain; other site 1271864010777 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1271864010778 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1271864010779 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1271864010780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1271864010781 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1271864010782 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1271864010783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1271864010784 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1271864010785 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1271864010786 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1271864010787 putative ribose interaction site [chemical binding]; other site 1271864010788 putative ADP binding site [chemical binding]; other site 1271864010789 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1271864010790 active site 1271864010791 nucleotide binding site [chemical binding]; other site 1271864010792 HIGH motif; other site 1271864010793 KMSKS motif; other site 1271864010794 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1271864010795 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1271864010796 metal binding triad; other site 1271864010797 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1271864010798 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1271864010799 metal binding triad; other site 1271864010800 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1271864010801 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1271864010802 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1271864010803 putative active site [active] 1271864010804 putative metal binding residues [ion binding]; other site 1271864010805 signature motif; other site 1271864010806 putative triphosphate binding site [ion binding]; other site 1271864010807 CHAD domain; Region: CHAD; cl10506 1271864010808 SH3 domain-containing protein; Provisional; Region: PRK10884 1271864010809 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1271864010810 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1271864010811 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1271864010812 active site 1271864010813 NTP binding site [chemical binding]; other site 1271864010814 metal binding triad [ion binding]; metal-binding site 1271864010815 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1271864010816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1271864010817 Zn2+ binding site [ion binding]; other site 1271864010818 Mg2+ binding site [ion binding]; other site 1271864010819 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1271864010820 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1271864010821 homooctamer interface [polypeptide binding]; other site 1271864010822 active site 1271864010823 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1271864010824 UGMP family protein; Validated; Region: PRK09604 1271864010825 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1271864010826 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1271864010827 DNA primase; Validated; Region: dnaG; PRK05667 1271864010828 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1271864010829 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1271864010830 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1271864010831 active site 1271864010832 metal binding site [ion binding]; metal-binding site 1271864010833 interdomain interaction site; other site 1271864010834 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1271864010835 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1271864010836 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1271864010837 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1271864010838 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1271864010839 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1271864010840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1271864010841 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1271864010842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1271864010843 DNA binding residues [nucleotide binding] 1271864010844 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1271864010845 active site 1271864010846 SUMO-1 interface [polypeptide binding]; other site 1271864010847 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1271864010848 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1271864010849 FAD binding pocket [chemical binding]; other site 1271864010850 FAD binding motif [chemical binding]; other site 1271864010851 phosphate binding motif [ion binding]; other site 1271864010852 NAD binding pocket [chemical binding]; other site 1271864010853 Predicted transcriptional regulators [Transcription]; Region: COG1695 1271864010854 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1271864010855 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1271864010856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864010857 dimerization interface [polypeptide binding]; other site 1271864010858 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1271864010859 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864010860 dimer interface [polypeptide binding]; other site 1271864010861 putative CheW interface [polypeptide binding]; other site 1271864010862 PAS fold; Region: PAS_3; pfam08447 1271864010863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864010864 putative active site [active] 1271864010865 heme pocket [chemical binding]; other site 1271864010866 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1271864010867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864010868 dimer interface [polypeptide binding]; other site 1271864010869 putative CheW interface [polypeptide binding]; other site 1271864010870 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1271864010871 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1271864010872 inhibitor-cofactor binding pocket; inhibition site 1271864010873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864010874 catalytic residue [active] 1271864010875 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1271864010876 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1271864010877 active site 1271864010878 FMN binding site [chemical binding]; other site 1271864010879 2,4-decadienoyl-CoA binding site; other site 1271864010880 catalytic residue [active] 1271864010881 4Fe-4S cluster binding site [ion binding]; other site 1271864010882 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1271864010883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864010884 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1271864010885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864010886 S-adenosylmethionine binding site [chemical binding]; other site 1271864010887 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1271864010888 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1271864010889 putative active site [active] 1271864010890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1271864010891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1271864010892 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1271864010893 serine/threonine transporter SstT; Provisional; Region: PRK13628 1271864010894 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1271864010895 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1271864010896 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1271864010897 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1271864010898 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1271864010899 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1271864010900 Predicted membrane protein [Function unknown]; Region: COG5393 1271864010901 YqjK-like protein; Region: YqjK; pfam13997 1271864010902 Predicted membrane protein [Function unknown]; Region: COG2259 1271864010903 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1271864010904 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1271864010905 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1271864010906 putative dimer interface [polypeptide binding]; other site 1271864010907 N-terminal domain interface [polypeptide binding]; other site 1271864010908 putative substrate binding pocket (H-site) [chemical binding]; other site 1271864010909 Predicted membrane protein [Function unknown]; Region: COG3152 1271864010910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864010911 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1271864010912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864010913 dimerization interface [polypeptide binding]; other site 1271864010914 Pirin-related protein [General function prediction only]; Region: COG1741 1271864010915 Pirin; Region: Pirin; pfam02678 1271864010916 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1271864010917 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1271864010918 serine transporter; Region: stp; TIGR00814 1271864010919 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1271864010920 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1271864010921 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1271864010922 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1271864010923 Pyruvate formate lyase 1; Region: PFL1; cd01678 1271864010924 coenzyme A binding site [chemical binding]; other site 1271864010925 active site 1271864010926 catalytic residues [active] 1271864010927 glycine loop; other site 1271864010928 propionate/acetate kinase; Provisional; Region: PRK12379 1271864010929 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1271864010930 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1271864010931 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1271864010932 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1271864010933 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1271864010934 tetramer interface [polypeptide binding]; other site 1271864010935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864010936 catalytic residue [active] 1271864010937 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1271864010938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864010939 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1271864010940 putative substrate binding pocket [chemical binding]; other site 1271864010941 putative dimerization interface [polypeptide binding]; other site 1271864010942 glycerate kinase I; Provisional; Region: PRK10342 1271864010943 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1271864010944 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1271864010945 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1271864010946 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1271864010947 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1271864010948 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1271864010949 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1271864010950 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1271864010951 intersubunit interface [polypeptide binding]; other site 1271864010952 active site 1271864010953 zinc binding site [ion binding]; other site 1271864010954 Na+ binding site [ion binding]; other site 1271864010955 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1271864010956 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864010957 active site 1271864010958 phosphorylation site [posttranslational modification] 1271864010959 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1271864010960 active site 1271864010961 P-loop; other site 1271864010962 phosphorylation site [posttranslational modification] 1271864010963 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1271864010964 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1271864010965 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1271864010966 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1271864010967 putative NAD(P) binding site [chemical binding]; other site 1271864010968 catalytic Zn binding site [ion binding]; other site 1271864010969 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864010970 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1271864010971 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864010972 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1271864010973 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1271864010974 putative SAM binding site [chemical binding]; other site 1271864010975 putative homodimer interface [polypeptide binding]; other site 1271864010976 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1271864010977 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1271864010978 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1271864010979 putative ligand binding site [chemical binding]; other site 1271864010980 TIGR00252 family protein; Region: TIGR00252 1271864010981 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1271864010982 dimer interface [polypeptide binding]; other site 1271864010983 active site 1271864010984 outer membrane lipoprotein; Provisional; Region: PRK11023 1271864010985 BON domain; Region: BON; pfam04972 1271864010986 BON domain; Region: BON; pfam04972 1271864010987 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1271864010988 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1271864010989 NAD binding site [chemical binding]; other site 1271864010990 active site 1271864010991 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1271864010992 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1271864010993 proposed catalytic triad [active] 1271864010994 conserved cys residue [active] 1271864010995 hypothetical protein; Provisional; Region: PRK03467 1271864010996 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1271864010997 GIY-YIG motif/motif A; other site 1271864010998 putative active site [active] 1271864010999 putative metal binding site [ion binding]; other site 1271864011000 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1271864011001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864011002 Coenzyme A binding pocket [chemical binding]; other site 1271864011003 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1271864011004 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1271864011005 Peptidase family U32; Region: Peptidase_U32; pfam01136 1271864011006 putative protease; Provisional; Region: PRK15447 1271864011007 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1271864011008 hypothetical protein; Provisional; Region: PRK10508 1271864011009 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1271864011010 tryptophan permease; Provisional; Region: PRK10483 1271864011011 aromatic amino acid transport protein; Region: araaP; TIGR00837 1271864011012 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1271864011013 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1271864011014 ATP binding site [chemical binding]; other site 1271864011015 Mg++ binding site [ion binding]; other site 1271864011016 motif III; other site 1271864011017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864011018 nucleotide binding region [chemical binding]; other site 1271864011019 ATP-binding site [chemical binding]; other site 1271864011020 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1271864011021 putative RNA binding site [nucleotide binding]; other site 1271864011022 lipoprotein NlpI; Provisional; Region: PRK11189 1271864011023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1271864011024 binding surface 1271864011025 TPR motif; other site 1271864011026 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1271864011027 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1271864011028 RNase E interface [polypeptide binding]; other site 1271864011029 trimer interface [polypeptide binding]; other site 1271864011030 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1271864011031 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1271864011032 RNase E interface [polypeptide binding]; other site 1271864011033 trimer interface [polypeptide binding]; other site 1271864011034 active site 1271864011035 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1271864011036 putative nucleic acid binding region [nucleotide binding]; other site 1271864011037 G-X-X-G motif; other site 1271864011038 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1271864011039 RNA binding site [nucleotide binding]; other site 1271864011040 domain interface; other site 1271864011041 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1271864011042 16S/18S rRNA binding site [nucleotide binding]; other site 1271864011043 S13e-L30e interaction site [polypeptide binding]; other site 1271864011044 25S rRNA binding site [nucleotide binding]; other site 1271864011045 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1271864011046 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1271864011047 RNA binding site [nucleotide binding]; other site 1271864011048 active site 1271864011049 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1271864011050 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1271864011051 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1271864011052 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1271864011053 translation initiation factor IF-2; Region: IF-2; TIGR00487 1271864011054 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1271864011055 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1271864011056 G1 box; other site 1271864011057 putative GEF interaction site [polypeptide binding]; other site 1271864011058 GTP/Mg2+ binding site [chemical binding]; other site 1271864011059 Switch I region; other site 1271864011060 G2 box; other site 1271864011061 G3 box; other site 1271864011062 Switch II region; other site 1271864011063 G4 box; other site 1271864011064 G5 box; other site 1271864011065 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1271864011066 Translation-initiation factor 2; Region: IF-2; pfam11987 1271864011067 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1271864011068 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1271864011069 NusA N-terminal domain; Region: NusA_N; pfam08529 1271864011070 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1271864011071 RNA binding site [nucleotide binding]; other site 1271864011072 homodimer interface [polypeptide binding]; other site 1271864011073 NusA-like KH domain; Region: KH_5; pfam13184 1271864011074 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1271864011075 G-X-X-G motif; other site 1271864011076 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1271864011077 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1271864011078 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1271864011079 Sm and related proteins; Region: Sm_like; cl00259 1271864011080 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1271864011081 putative oligomer interface [polypeptide binding]; other site 1271864011082 putative RNA binding site [nucleotide binding]; other site 1271864011083 argininosuccinate synthase; Validated; Region: PRK05370 1271864011084 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1271864011085 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1271864011086 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1271864011087 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1271864011088 active site 1271864011089 substrate binding site [chemical binding]; other site 1271864011090 metal binding site [ion binding]; metal-binding site 1271864011091 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1271864011092 dihydropteroate synthase; Region: DHPS; TIGR01496 1271864011093 substrate binding pocket [chemical binding]; other site 1271864011094 dimer interface [polypeptide binding]; other site 1271864011095 inhibitor binding site; inhibition site 1271864011096 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1271864011097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864011098 Walker A motif; other site 1271864011099 ATP binding site [chemical binding]; other site 1271864011100 Walker B motif; other site 1271864011101 arginine finger; other site 1271864011102 Peptidase family M41; Region: Peptidase_M41; pfam01434 1271864011103 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1271864011104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864011105 S-adenosylmethionine binding site [chemical binding]; other site 1271864011106 RNA-binding protein YhbY; Provisional; Region: PRK10343 1271864011107 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1271864011108 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1271864011109 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1271864011110 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1271864011111 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1271864011112 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1271864011113 GTP1/OBG; Region: GTP1_OBG; pfam01018 1271864011114 Obg GTPase; Region: Obg; cd01898 1271864011115 G1 box; other site 1271864011116 GTP/Mg2+ binding site [chemical binding]; other site 1271864011117 Switch I region; other site 1271864011118 G2 box; other site 1271864011119 G3 box; other site 1271864011120 Switch II region; other site 1271864011121 G4 box; other site 1271864011122 G5 box; other site 1271864011123 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1271864011124 EamA-like transporter family; Region: EamA; pfam00892 1271864011125 EamA-like transporter family; Region: EamA; pfam00892 1271864011126 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1271864011127 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1271864011128 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1271864011129 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1271864011130 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1271864011131 substrate binding pocket [chemical binding]; other site 1271864011132 chain length determination region; other site 1271864011133 substrate-Mg2+ binding site; other site 1271864011134 catalytic residues [active] 1271864011135 aspartate-rich region 1; other site 1271864011136 active site lid residues [active] 1271864011137 aspartate-rich region 2; other site 1271864011138 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1271864011139 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1271864011140 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1271864011141 hinge; other site 1271864011142 active site 1271864011143 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1271864011144 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1271864011145 anti sigma factor interaction site; other site 1271864011146 regulatory phosphorylation site [posttranslational modification]; other site 1271864011147 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1271864011148 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1271864011149 mce related protein; Region: MCE; pfam02470 1271864011150 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1271864011151 conserved hypothetical integral membrane protein; Region: TIGR00056 1271864011152 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1271864011153 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1271864011154 Walker A/P-loop; other site 1271864011155 ATP binding site [chemical binding]; other site 1271864011156 Q-loop/lid; other site 1271864011157 ABC transporter signature motif; other site 1271864011158 Walker B; other site 1271864011159 D-loop; other site 1271864011160 H-loop/switch region; other site 1271864011161 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1271864011162 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1271864011163 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1271864011164 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1271864011165 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1271864011166 putative active site [active] 1271864011167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1271864011168 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1271864011169 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1271864011170 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1271864011171 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1271864011172 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1271864011173 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1271864011174 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1271864011175 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1271864011176 Walker A/P-loop; other site 1271864011177 ATP binding site [chemical binding]; other site 1271864011178 Q-loop/lid; other site 1271864011179 ABC transporter signature motif; other site 1271864011180 Walker B; other site 1271864011181 D-loop; other site 1271864011182 H-loop/switch region; other site 1271864011183 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1271864011184 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1271864011185 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1271864011186 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1271864011187 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1271864011188 30S subunit binding site; other site 1271864011189 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864011190 active site 1271864011191 phosphorylation site [posttranslational modification] 1271864011192 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1271864011193 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1271864011194 dimerization domain swap beta strand [polypeptide binding]; other site 1271864011195 regulatory protein interface [polypeptide binding]; other site 1271864011196 active site 1271864011197 regulatory phosphorylation site [posttranslational modification]; other site 1271864011198 hypothetical protein; Provisional; Region: PRK10345 1271864011199 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1271864011200 Transglycosylase; Region: Transgly; cl17702 1271864011201 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1271864011202 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1271864011203 conserved cys residue [active] 1271864011204 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1271864011205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864011206 putative active site [active] 1271864011207 heme pocket [chemical binding]; other site 1271864011208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864011209 dimer interface [polypeptide binding]; other site 1271864011210 phosphorylation site [posttranslational modification] 1271864011211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864011212 ATP binding site [chemical binding]; other site 1271864011213 Mg2+ binding site [ion binding]; other site 1271864011214 G-X-G motif; other site 1271864011215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864011216 active site 1271864011217 phosphorylation site [posttranslational modification] 1271864011218 intermolecular recognition site; other site 1271864011219 dimerization interface [polypeptide binding]; other site 1271864011220 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1271864011221 putative binding surface; other site 1271864011222 active site 1271864011223 radical SAM protein, TIGR01212 family; Region: TIGR01212 1271864011224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864011225 FeS/SAM binding site; other site 1271864011226 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1271864011227 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1271864011228 active site 1271864011229 dimer interface [polypeptide binding]; other site 1271864011230 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1271864011231 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1271864011232 active site 1271864011233 FMN binding site [chemical binding]; other site 1271864011234 substrate binding site [chemical binding]; other site 1271864011235 3Fe-4S cluster binding site [ion binding]; other site 1271864011236 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1271864011237 domain interface; other site 1271864011238 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1271864011239 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864011240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864011241 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1271864011242 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1271864011243 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1271864011244 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1271864011245 Na binding site [ion binding]; other site 1271864011246 putative substrate binding site [chemical binding]; other site 1271864011247 cytosine deaminase; Provisional; Region: PRK09230 1271864011248 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1271864011249 active site 1271864011250 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1271864011251 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1271864011252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864011253 nucleotide binding site [chemical binding]; other site 1271864011254 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1271864011255 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1271864011256 putative active site cavity [active] 1271864011257 putative sialic acid transporter; Provisional; Region: PRK03893 1271864011258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864011259 putative substrate translocation pore; other site 1271864011260 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1271864011261 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1271864011262 inhibitor site; inhibition site 1271864011263 active site 1271864011264 dimer interface [polypeptide binding]; other site 1271864011265 catalytic residue [active] 1271864011266 transcriptional regulator NanR; Provisional; Region: PRK03837 1271864011267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864011268 DNA-binding site [nucleotide binding]; DNA binding site 1271864011269 FCD domain; Region: FCD; pfam07729 1271864011270 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 1271864011271 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1271864011272 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1271864011273 C-terminal domain interface [polypeptide binding]; other site 1271864011274 putative GSH binding site (G-site) [chemical binding]; other site 1271864011275 dimer interface [polypeptide binding]; other site 1271864011276 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1271864011277 dimer interface [polypeptide binding]; other site 1271864011278 N-terminal domain interface [polypeptide binding]; other site 1271864011279 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1271864011280 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1271864011281 23S rRNA interface [nucleotide binding]; other site 1271864011282 L3 interface [polypeptide binding]; other site 1271864011283 Predicted ATPase [General function prediction only]; Region: COG1485 1271864011284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1271864011285 hypothetical protein; Provisional; Region: PRK11677 1271864011286 serine endoprotease; Provisional; Region: PRK10139 1271864011287 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1271864011288 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1271864011289 protein binding site [polypeptide binding]; other site 1271864011290 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1271864011291 serine endoprotease; Provisional; Region: PRK10898 1271864011292 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1271864011293 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1271864011294 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1271864011295 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1271864011296 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1271864011297 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1271864011298 active site 1271864011299 catalytic residues [active] 1271864011300 metal binding site [ion binding]; metal-binding site 1271864011301 homodimer binding site [polypeptide binding]; other site 1271864011302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1271864011303 carboxyltransferase (CT) interaction site; other site 1271864011304 biotinylation site [posttranslational modification]; other site 1271864011305 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1271864011306 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1271864011307 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1271864011308 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1271864011309 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1271864011310 transmembrane helices; other site 1271864011311 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1271864011312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864011313 DNA-binding site [nucleotide binding]; DNA binding site 1271864011314 FCD domain; Region: FCD; pfam07729 1271864011315 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1271864011316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864011317 DNA-binding site [nucleotide binding]; DNA binding site 1271864011318 malate dehydrogenase; Provisional; Region: PRK05086 1271864011319 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1271864011320 NAD binding site [chemical binding]; other site 1271864011321 dimerization interface [polypeptide binding]; other site 1271864011322 Substrate binding site [chemical binding]; other site 1271864011323 arginine repressor; Provisional; Region: PRK05066 1271864011324 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1271864011325 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1271864011326 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864011327 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1271864011328 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1271864011329 RNAase interaction site [polypeptide binding]; other site 1271864011330 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1271864011331 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1271864011332 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1271864011333 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864011334 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864011335 efflux system membrane protein; Provisional; Region: PRK11594 1271864011336 transcriptional regulator; Provisional; Region: PRK10632 1271864011337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864011338 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1271864011339 putative effector binding pocket; other site 1271864011340 dimerization interface [polypeptide binding]; other site 1271864011341 protease TldD; Provisional; Region: tldD; PRK10735 1271864011342 hypothetical protein; Provisional; Region: PRK10899 1271864011343 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1271864011344 ribonuclease G; Provisional; Region: PRK11712 1271864011345 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1271864011346 homodimer interface [polypeptide binding]; other site 1271864011347 oligonucleotide binding site [chemical binding]; other site 1271864011348 Maf-like protein; Region: Maf; pfam02545 1271864011349 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1271864011350 active site 1271864011351 dimer interface [polypeptide binding]; other site 1271864011352 rod shape-determining protein MreD; Provisional; Region: PRK11060 1271864011353 rod shape-determining protein MreC; Region: mreC; TIGR00219 1271864011354 rod shape-determining protein MreC; Region: MreC; pfam04085 1271864011355 rod shape-determining protein MreB; Provisional; Region: PRK13927 1271864011356 MreB and similar proteins; Region: MreB_like; cd10225 1271864011357 nucleotide binding site [chemical binding]; other site 1271864011358 Mg binding site [ion binding]; other site 1271864011359 putative protofilament interaction site [polypeptide binding]; other site 1271864011360 RodZ interaction site [polypeptide binding]; other site 1271864011361 regulatory protein CsrD; Provisional; Region: PRK11059 1271864011362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864011363 metal binding site [ion binding]; metal-binding site 1271864011364 active site 1271864011365 I-site; other site 1271864011366 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864011367 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1271864011368 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1271864011369 NADP binding site [chemical binding]; other site 1271864011370 dimer interface [polypeptide binding]; other site 1271864011371 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1271864011372 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1271864011373 Moco binding site; other site 1271864011374 metal coordination site [ion binding]; other site 1271864011375 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1271864011376 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1271864011377 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1271864011378 carboxyltransferase (CT) interaction site; other site 1271864011379 biotinylation site [posttranslational modification]; other site 1271864011380 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1271864011381 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1271864011382 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1271864011383 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1271864011384 hypothetical protein; Provisional; Region: PRK10633 1271864011385 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1271864011386 Na binding site [ion binding]; other site 1271864011387 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1271864011388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1271864011389 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1271864011390 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1271864011391 FMN binding site [chemical binding]; other site 1271864011392 active site 1271864011393 catalytic residues [active] 1271864011394 substrate binding site [chemical binding]; other site 1271864011395 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1271864011396 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1271864011397 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1271864011398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864011399 DNA methylase; Region: N6_N4_Mtase; pfam01555 1271864011400 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1271864011401 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1271864011402 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1271864011403 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1271864011404 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864011405 metal binding site [ion binding]; metal-binding site 1271864011406 active site 1271864011407 I-site; other site 1271864011408 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864011409 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1271864011410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864011411 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1271864011412 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1271864011413 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864011414 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864011415 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1271864011416 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1271864011417 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1271864011418 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1271864011419 trimer interface [polypeptide binding]; other site 1271864011420 putative metal binding site [ion binding]; other site 1271864011421 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1271864011422 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1271864011423 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1271864011424 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1271864011425 shikimate binding site; other site 1271864011426 NAD(P) binding site [chemical binding]; other site 1271864011427 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1271864011428 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1271864011429 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1271864011430 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1271864011431 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1271864011432 hypothetical protein; Validated; Region: PRK03430 1271864011433 hypothetical protein; Provisional; Region: PRK10736 1271864011434 DNA protecting protein DprA; Region: dprA; TIGR00732 1271864011435 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1271864011436 active site 1271864011437 catalytic residues [active] 1271864011438 metal binding site [ion binding]; metal-binding site 1271864011439 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1271864011440 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1271864011441 putative active site [active] 1271864011442 substrate binding site [chemical binding]; other site 1271864011443 putative cosubstrate binding site; other site 1271864011444 catalytic site [active] 1271864011445 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1271864011446 substrate binding site [chemical binding]; other site 1271864011447 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1271864011448 putative RNA binding site [nucleotide binding]; other site 1271864011449 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1271864011450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864011451 S-adenosylmethionine binding site [chemical binding]; other site 1271864011452 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1271864011453 TrkA-N domain; Region: TrkA_N; pfam02254 1271864011454 TrkA-C domain; Region: TrkA_C; pfam02080 1271864011455 TrkA-N domain; Region: TrkA_N; pfam02254 1271864011456 TrkA-C domain; Region: TrkA_C; pfam02080 1271864011457 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1271864011458 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1271864011459 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1271864011460 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1271864011461 DNA binding residues [nucleotide binding] 1271864011462 dimer interface [polypeptide binding]; other site 1271864011463 metal binding site [ion binding]; metal-binding site 1271864011464 hypothetical protein; Provisional; Region: PRK10203 1271864011465 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1271864011466 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1271864011467 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1271864011468 alphaNTD homodimer interface [polypeptide binding]; other site 1271864011469 alphaNTD - beta interaction site [polypeptide binding]; other site 1271864011470 alphaNTD - beta' interaction site [polypeptide binding]; other site 1271864011471 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1271864011472 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1271864011473 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1271864011474 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864011475 RNA binding surface [nucleotide binding]; other site 1271864011476 30S ribosomal protein S11; Validated; Region: PRK05309 1271864011477 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1271864011478 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1271864011479 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1271864011480 SecY translocase; Region: SecY; pfam00344 1271864011481 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1271864011482 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1271864011483 23S rRNA binding site [nucleotide binding]; other site 1271864011484 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1271864011485 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1271864011486 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1271864011487 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1271864011488 23S rRNA interface [nucleotide binding]; other site 1271864011489 5S rRNA interface [nucleotide binding]; other site 1271864011490 L27 interface [polypeptide binding]; other site 1271864011491 L5 interface [polypeptide binding]; other site 1271864011492 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1271864011493 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1271864011494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1271864011495 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1271864011496 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1271864011497 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1271864011498 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1271864011499 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1271864011500 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1271864011501 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1271864011502 RNA binding site [nucleotide binding]; other site 1271864011503 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1271864011504 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1271864011505 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1271864011506 23S rRNA interface [nucleotide binding]; other site 1271864011507 putative translocon interaction site; other site 1271864011508 signal recognition particle (SRP54) interaction site; other site 1271864011509 L23 interface [polypeptide binding]; other site 1271864011510 trigger factor interaction site; other site 1271864011511 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1271864011512 23S rRNA interface [nucleotide binding]; other site 1271864011513 5S rRNA interface [nucleotide binding]; other site 1271864011514 putative antibiotic binding site [chemical binding]; other site 1271864011515 L25 interface [polypeptide binding]; other site 1271864011516 L27 interface [polypeptide binding]; other site 1271864011517 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1271864011518 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1271864011519 G-X-X-G motif; other site 1271864011520 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1271864011521 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1271864011522 protein-rRNA interface [nucleotide binding]; other site 1271864011523 putative translocon binding site; other site 1271864011524 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1271864011525 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1271864011526 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1271864011527 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1271864011528 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1271864011529 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1271864011530 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1271864011531 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1271864011532 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1271864011533 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1271864011534 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1271864011535 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1271864011536 heme binding site [chemical binding]; other site 1271864011537 ferroxidase pore; other site 1271864011538 ferroxidase diiron center [ion binding]; other site 1271864011539 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1271864011540 elongation factor Tu; Reviewed; Region: PRK00049 1271864011541 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1271864011542 G1 box; other site 1271864011543 GEF interaction site [polypeptide binding]; other site 1271864011544 GTP/Mg2+ binding site [chemical binding]; other site 1271864011545 Switch I region; other site 1271864011546 G2 box; other site 1271864011547 G3 box; other site 1271864011548 Switch II region; other site 1271864011549 G4 box; other site 1271864011550 G5 box; other site 1271864011551 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1271864011552 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1271864011553 Antibiotic Binding Site [chemical binding]; other site 1271864011554 elongation factor G; Reviewed; Region: PRK00007 1271864011555 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1271864011556 G1 box; other site 1271864011557 putative GEF interaction site [polypeptide binding]; other site 1271864011558 GTP/Mg2+ binding site [chemical binding]; other site 1271864011559 Switch I region; other site 1271864011560 G2 box; other site 1271864011561 G3 box; other site 1271864011562 Switch II region; other site 1271864011563 G4 box; other site 1271864011564 G5 box; other site 1271864011565 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1271864011566 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1271864011567 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1271864011568 30S ribosomal protein S7; Validated; Region: PRK05302 1271864011569 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1271864011570 S17 interaction site [polypeptide binding]; other site 1271864011571 S8 interaction site; other site 1271864011572 16S rRNA interaction site [nucleotide binding]; other site 1271864011573 streptomycin interaction site [chemical binding]; other site 1271864011574 23S rRNA interaction site [nucleotide binding]; other site 1271864011575 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1271864011576 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1271864011577 sulfur relay protein TusC; Validated; Region: PRK00211 1271864011578 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1271864011579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1271864011580 YheO-like PAS domain; Region: PAS_6; pfam08348 1271864011581 HTH domain; Region: HTH_22; pfam13309 1271864011582 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1271864011583 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1271864011584 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1271864011585 phi X174 lysis protein; Provisional; Region: PRK02793 1271864011586 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1271864011587 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1271864011588 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1271864011589 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1271864011590 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1271864011591 TrkA-N domain; Region: TrkA_N; pfam02254 1271864011592 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1271864011593 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1271864011594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864011595 Walker A/P-loop; other site 1271864011596 ATP binding site [chemical binding]; other site 1271864011597 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864011598 ABC transporter signature motif; other site 1271864011599 Walker B; other site 1271864011600 D-loop; other site 1271864011601 ABC transporter; Region: ABC_tran_2; pfam12848 1271864011602 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1271864011603 putative monooxygenase; Provisional; Region: PRK11118 1271864011604 putative hydrolase; Provisional; Region: PRK10985 1271864011605 hypothetical protein; Provisional; Region: PRK04966 1271864011606 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1271864011607 active site 1271864011608 hypothetical protein; Provisional; Region: PRK10738 1271864011609 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1271864011610 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1271864011611 ligand binding site [chemical binding]; other site 1271864011612 flexible hinge region; other site 1271864011613 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1271864011614 putative switch regulator; other site 1271864011615 non-specific DNA interactions [nucleotide binding]; other site 1271864011616 DNA binding site [nucleotide binding] 1271864011617 sequence specific DNA binding site [nucleotide binding]; other site 1271864011618 putative cAMP binding site [chemical binding]; other site 1271864011619 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1271864011620 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1271864011621 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1271864011622 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1271864011623 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1271864011624 inhibitor-cofactor binding pocket; inhibition site 1271864011625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864011626 catalytic residue [active] 1271864011627 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1271864011628 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1271864011629 glutamine binding [chemical binding]; other site 1271864011630 catalytic triad [active] 1271864011631 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1271864011632 cell filamentation protein Fic; Provisional; Region: PRK10347 1271864011633 hypothetical protein; Provisional; Region: PRK10204 1271864011634 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1271864011635 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1271864011636 substrate binding site [chemical binding]; other site 1271864011637 putative transporter; Provisional; Region: PRK03699 1271864011638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864011639 putative substrate translocation pore; other site 1271864011640 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1271864011641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864011642 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1271864011643 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1271864011644 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1271864011645 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1271864011646 nitrite transporter NirC; Provisional; Region: PRK11562 1271864011647 siroheme synthase; Provisional; Region: cysG; PRK10637 1271864011648 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1271864011649 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1271864011650 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1271864011651 active site 1271864011652 SAM binding site [chemical binding]; other site 1271864011653 homodimer interface [polypeptide binding]; other site 1271864011654 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1271864011655 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1271864011656 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1271864011657 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1271864011658 active site 1271864011659 HIGH motif; other site 1271864011660 dimer interface [polypeptide binding]; other site 1271864011661 KMSKS motif; other site 1271864011662 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1271864011663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864011664 motif II; other site 1271864011665 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1271864011666 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1271864011667 substrate binding site [chemical binding]; other site 1271864011668 hexamer interface [polypeptide binding]; other site 1271864011669 metal binding site [ion binding]; metal-binding site 1271864011670 DNA adenine methylase; Provisional; Region: PRK10904 1271864011671 cell division protein DamX; Validated; Region: PRK10905 1271864011672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1271864011673 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1271864011674 active site 1271864011675 dimer interface [polypeptide binding]; other site 1271864011676 metal binding site [ion binding]; metal-binding site 1271864011677 shikimate kinase; Reviewed; Region: aroK; PRK00131 1271864011678 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1271864011679 ADP binding site [chemical binding]; other site 1271864011680 magnesium binding site [ion binding]; other site 1271864011681 putative shikimate binding site; other site 1271864011682 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1271864011683 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1271864011684 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1271864011685 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1271864011686 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1271864011687 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1271864011688 Transglycosylase; Region: Transgly; pfam00912 1271864011689 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1271864011690 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1271864011691 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1271864011692 ADP-ribose binding site [chemical binding]; other site 1271864011693 dimer interface [polypeptide binding]; other site 1271864011694 active site 1271864011695 nudix motif; other site 1271864011696 metal binding site [ion binding]; metal-binding site 1271864011697 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1271864011698 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1271864011699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864011700 motif II; other site 1271864011701 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1271864011702 RNA binding surface [nucleotide binding]; other site 1271864011703 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1271864011704 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1271864011705 dimerization interface [polypeptide binding]; other site 1271864011706 domain crossover interface; other site 1271864011707 redox-dependent activation switch; other site 1271864011708 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1271864011709 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1271864011710 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1271864011711 active site 1271864011712 substrate-binding site [chemical binding]; other site 1271864011713 metal-binding site [ion binding] 1271864011714 ATP binding site [chemical binding]; other site 1271864011715 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1271864011716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864011717 dimerization interface [polypeptide binding]; other site 1271864011718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864011719 dimer interface [polypeptide binding]; other site 1271864011720 phosphorylation site [posttranslational modification] 1271864011721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864011722 ATP binding site [chemical binding]; other site 1271864011723 G-X-G motif; other site 1271864011724 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1271864011725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864011726 active site 1271864011727 phosphorylation site [posttranslational modification] 1271864011728 intermolecular recognition site; other site 1271864011729 dimerization interface [polypeptide binding]; other site 1271864011730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864011731 DNA binding site [nucleotide binding] 1271864011732 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1271864011733 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1271864011734 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1271864011735 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1271864011736 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1271864011737 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1271864011738 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1271864011739 RNA binding site [nucleotide binding]; other site 1271864011740 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1271864011741 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1271864011742 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1271864011743 G1 box; other site 1271864011744 GTP/Mg2+ binding site [chemical binding]; other site 1271864011745 Switch I region; other site 1271864011746 G2 box; other site 1271864011747 G3 box; other site 1271864011748 Switch II region; other site 1271864011749 G4 box; other site 1271864011750 G5 box; other site 1271864011751 Nucleoside recognition; Region: Gate; pfam07670 1271864011752 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1271864011753 Nucleoside recognition; Region: Gate; pfam07670 1271864011754 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1271864011755 hypothetical protein; Provisional; Region: PRK09956 1271864011756 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1271864011757 carboxylesterase BioH; Provisional; Region: PRK10349 1271864011758 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1271864011759 DNA utilization protein GntX; Provisional; Region: PRK11595 1271864011760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864011761 active site 1271864011762 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1271864011763 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1271864011764 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1271864011765 high-affinity gluconate transporter; Provisional; Region: PRK14984 1271864011766 gluconate transporter; Region: gntP; TIGR00791 1271864011767 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1271864011768 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1271864011769 maltodextrin phosphorylase; Provisional; Region: PRK14985 1271864011770 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1271864011771 homodimer interface [polypeptide binding]; other site 1271864011772 active site pocket [active] 1271864011773 transcriptional regulator MalT; Provisional; Region: PRK04841 1271864011774 AAA ATPase domain; Region: AAA_16; pfam13191 1271864011775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864011776 DNA binding residues [nucleotide binding] 1271864011777 dimerization interface [polypeptide binding]; other site 1271864011778 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 1271864011779 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1271864011780 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1271864011781 putative active site [active] 1271864011782 adenylation catalytic residue [active] 1271864011783 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1271864011784 hypothetical protein; Reviewed; Region: PRK09588 1271864011785 TROVE domain; Region: TROVE; pfam05731 1271864011786 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1271864011787 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1271864011788 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864011789 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1271864011790 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1271864011791 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1271864011792 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1271864011793 active site residue [active] 1271864011794 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1271864011795 hypothetical protein; Provisional; Region: PRK09781 1271864011796 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1271864011797 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1271864011798 dimer interface [polypeptide binding]; other site 1271864011799 active site 1271864011800 metal binding site [ion binding]; metal-binding site 1271864011801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864011802 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864011803 putative substrate translocation pore; other site 1271864011804 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 1271864011805 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1271864011806 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1271864011807 inhibitor site; inhibition site 1271864011808 active site 1271864011809 dimer interface [polypeptide binding]; other site 1271864011810 catalytic residue [active] 1271864011811 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1271864011812 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1271864011813 Bacterial transcriptional regulator; Region: IclR; pfam01614 1271864011814 glycogen phosphorylase; Provisional; Region: PRK14986 1271864011815 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1271864011816 homodimer interface [polypeptide binding]; other site 1271864011817 active site pocket [active] 1271864011818 glycogen synthase; Provisional; Region: glgA; PRK00654 1271864011819 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1271864011820 ADP-binding pocket [chemical binding]; other site 1271864011821 homodimer interface [polypeptide binding]; other site 1271864011822 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1271864011823 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1271864011824 ligand binding site; other site 1271864011825 oligomer interface; other site 1271864011826 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1271864011827 dimer interface [polypeptide binding]; other site 1271864011828 N-terminal domain interface [polypeptide binding]; other site 1271864011829 sulfate 1 binding site; other site 1271864011830 glycogen debranching enzyme; Provisional; Region: PRK03705 1271864011831 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1271864011832 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1271864011833 active site 1271864011834 catalytic site [active] 1271864011835 glycogen branching enzyme; Provisional; Region: PRK05402 1271864011836 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1271864011837 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1271864011838 active site 1271864011839 catalytic site [active] 1271864011840 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1271864011841 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1271864011842 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1271864011843 low affinity gluconate transporter; Provisional; Region: PRK10472 1271864011844 gluconate transporter; Region: gntP; TIGR00791 1271864011845 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1271864011846 ATP-binding site [chemical binding]; other site 1271864011847 Gluconate-6-phosphate binding site [chemical binding]; other site 1271864011848 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1271864011849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864011850 DNA binding site [nucleotide binding] 1271864011851 domain linker motif; other site 1271864011852 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1271864011853 putative ligand binding site [chemical binding]; other site 1271864011854 putative dimerization interface [polypeptide binding]; other site 1271864011855 Pirin-related protein [General function prediction only]; Region: COG1741 1271864011856 Pirin; Region: Pirin; pfam02678 1271864011857 putative oxidoreductase; Provisional; Region: PRK10206 1271864011858 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1271864011859 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1271864011860 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1271864011861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864011862 Coenzyme A binding pocket [chemical binding]; other site 1271864011863 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864011864 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1271864011865 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864011866 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1271864011867 substrate binding site [chemical binding]; other site 1271864011868 dimer interface [polypeptide binding]; other site 1271864011869 ATP binding site [chemical binding]; other site 1271864011870 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1271864011871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1271864011872 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1271864011873 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1271864011874 active site 1271864011875 substrate binding pocket [chemical binding]; other site 1271864011876 homodimer interaction site [polypeptide binding]; other site 1271864011877 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1271864011878 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1271864011879 hypothetical protein; Provisional; Region: PRK10350 1271864011880 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1271864011881 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1271864011882 putative active site [active] 1271864011883 catalytic site [active] 1271864011884 putative metal binding site [ion binding]; other site 1271864011885 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1271864011886 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1271864011887 Walker A/P-loop; other site 1271864011888 ATP binding site [chemical binding]; other site 1271864011889 Q-loop/lid; other site 1271864011890 ABC transporter signature motif; other site 1271864011891 Walker B; other site 1271864011892 D-loop; other site 1271864011893 H-loop/switch region; other site 1271864011894 TOBE domain; Region: TOBE_2; pfam08402 1271864011895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1271864011896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864011897 dimer interface [polypeptide binding]; other site 1271864011898 conserved gate region; other site 1271864011899 ABC-ATPase subunit interface; other site 1271864011900 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1271864011901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864011902 dimer interface [polypeptide binding]; other site 1271864011903 conserved gate region; other site 1271864011904 putative PBP binding loops; other site 1271864011905 ABC-ATPase subunit interface; other site 1271864011906 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1271864011907 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1271864011908 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1271864011909 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1271864011910 Walker A/P-loop; other site 1271864011911 ATP binding site [chemical binding]; other site 1271864011912 Q-loop/lid; other site 1271864011913 ABC transporter signature motif; other site 1271864011914 Walker B; other site 1271864011915 D-loop; other site 1271864011916 H-loop/switch region; other site 1271864011917 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1271864011918 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1271864011919 Walker A/P-loop; other site 1271864011920 ATP binding site [chemical binding]; other site 1271864011921 Q-loop/lid; other site 1271864011922 ABC transporter signature motif; other site 1271864011923 Walker B; other site 1271864011924 D-loop; other site 1271864011925 H-loop/switch region; other site 1271864011926 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1271864011927 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1271864011928 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1271864011929 TM-ABC transporter signature motif; other site 1271864011930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1271864011931 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1271864011932 TM-ABC transporter signature motif; other site 1271864011933 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1271864011934 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1271864011935 dimerization interface [polypeptide binding]; other site 1271864011936 ligand binding site [chemical binding]; other site 1271864011937 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1271864011938 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1271864011939 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1271864011940 dimerization interface [polypeptide binding]; other site 1271864011941 ligand binding site [chemical binding]; other site 1271864011942 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1271864011943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1271864011944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1271864011945 DNA binding residues [nucleotide binding] 1271864011946 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1271864011947 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1271864011948 cell division protein FtsE; Provisional; Region: PRK10908 1271864011949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864011950 Walker A/P-loop; other site 1271864011951 ATP binding site [chemical binding]; other site 1271864011952 Q-loop/lid; other site 1271864011953 ABC transporter signature motif; other site 1271864011954 Walker B; other site 1271864011955 D-loop; other site 1271864011956 H-loop/switch region; other site 1271864011957 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1271864011958 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1271864011959 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1271864011960 P loop; other site 1271864011961 GTP binding site [chemical binding]; other site 1271864011962 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1271864011963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864011964 S-adenosylmethionine binding site [chemical binding]; other site 1271864011965 hypothetical protein; Provisional; Region: PRK10910 1271864011966 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1271864011967 Predicted membrane protein [Function unknown]; Region: COG3714 1271864011968 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1271864011969 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1271864011970 metal-binding site [ion binding] 1271864011971 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1271864011972 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1271864011973 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1271864011974 dimer interface [polypeptide binding]; other site 1271864011975 ligand binding site [chemical binding]; other site 1271864011976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864011977 dimerization interface [polypeptide binding]; other site 1271864011978 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1271864011979 dimer interface [polypeptide binding]; other site 1271864011980 putative CheW interface [polypeptide binding]; other site 1271864011981 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1271864011982 CPxP motif; other site 1271864011983 hypothetical protein; Provisional; Region: PRK11212 1271864011984 hypothetical protein; Provisional; Region: PRK11615 1271864011985 major facilitator superfamily transporter; Provisional; Region: PRK05122 1271864011986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864011987 putative substrate translocation pore; other site 1271864011988 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1271864011989 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1271864011990 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1271864011991 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1271864011992 nickel responsive regulator; Provisional; Region: PRK02967 1271864011993 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1271864011994 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1271864011995 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1271864011996 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1271864011997 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1271864011998 Walker A/P-loop; other site 1271864011999 ATP binding site [chemical binding]; other site 1271864012000 Q-loop/lid; other site 1271864012001 ABC transporter signature motif; other site 1271864012002 Walker B; other site 1271864012003 D-loop; other site 1271864012004 H-loop/switch region; other site 1271864012005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1271864012006 Walker A/P-loop; other site 1271864012007 ATP binding site [chemical binding]; other site 1271864012008 Q-loop/lid; other site 1271864012009 ABC transporter signature motif; other site 1271864012010 Walker B; other site 1271864012011 D-loop; other site 1271864012012 H-loop/switch region; other site 1271864012013 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1271864012014 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1271864012015 HlyD family secretion protein; Region: HlyD; pfam00529 1271864012016 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1271864012017 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864012018 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1271864012019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864012020 dimerization interface [polypeptide binding]; other site 1271864012021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864012022 dimer interface [polypeptide binding]; other site 1271864012023 phosphorylation site [posttranslational modification] 1271864012024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864012025 ATP binding site [chemical binding]; other site 1271864012026 Mg2+ binding site [ion binding]; other site 1271864012027 G-X-G motif; other site 1271864012028 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1271864012029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864012030 active site 1271864012031 phosphorylation site [posttranslational modification] 1271864012032 intermolecular recognition site; other site 1271864012033 dimerization interface [polypeptide binding]; other site 1271864012034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864012035 DNA binding site [nucleotide binding] 1271864012036 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1271864012037 CopC domain; Region: CopC; pfam04234 1271864012038 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1271864012039 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1271864012040 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1271864012041 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1271864012042 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1271864012043 Peptidase family M23; Region: Peptidase_M23; pfam01551 1271864012044 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 1271864012045 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1271864012046 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1271864012047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864012048 motif II; other site 1271864012049 Protein of unknown function, DUF; Region: DUF411; cl01142 1271864012050 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1271864012051 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1271864012052 HlyD family secretion protein; Region: HlyD_3; pfam13437 1271864012053 periplasmic copper-binding protein; Provisional; Region: PRK09838 1271864012054 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1271864012055 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1271864012056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864012057 active site 1271864012058 phosphorylation site [posttranslational modification] 1271864012059 intermolecular recognition site; other site 1271864012060 dimerization interface [polypeptide binding]; other site 1271864012061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864012062 DNA binding site [nucleotide binding] 1271864012063 sensor kinase CusS; Provisional; Region: PRK09835 1271864012064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864012065 dimerization interface [polypeptide binding]; other site 1271864012066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864012067 dimer interface [polypeptide binding]; other site 1271864012068 phosphorylation site [posttranslational modification] 1271864012069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864012070 ATP binding site [chemical binding]; other site 1271864012071 Mg2+ binding site [ion binding]; other site 1271864012072 G-X-G motif; other site 1271864012073 Domain of unknown function (DUF305); Region: DUF305; cl17794 1271864012074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864012075 Walker A/P-loop; other site 1271864012076 ATP binding site [chemical binding]; other site 1271864012077 AAA ATPase domain; Region: AAA_15; pfam13175 1271864012078 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1271864012079 active site 1271864012080 metal binding site [ion binding]; metal-binding site 1271864012081 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864012082 salt bridge; other site 1271864012083 non-specific DNA binding site [nucleotide binding]; other site 1271864012084 sequence-specific DNA binding site [nucleotide binding]; other site 1271864012085 AAA ATPase domain; Region: AAA_16; pfam13191 1271864012086 AAA domain; Region: AAA_22; pfam13401 1271864012087 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1271864012088 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 1271864012089 Predicted flavoproteins [General function prediction only]; Region: COG2081 1271864012090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864012091 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1271864012092 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1271864012093 universal stress protein UspB; Provisional; Region: PRK04960 1271864012094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1271864012095 Ligand Binding Site [chemical binding]; other site 1271864012096 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1271864012097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012098 putative substrate translocation pore; other site 1271864012099 POT family; Region: PTR2; pfam00854 1271864012100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864012101 S-adenosylmethionine binding site [chemical binding]; other site 1271864012102 oligopeptidase A; Provisional; Region: PRK10911 1271864012103 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1271864012104 active site 1271864012105 Zn binding site [ion binding]; other site 1271864012106 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1271864012107 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1271864012108 active site 1271864012109 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1271864012110 glutathione reductase; Validated; Region: PRK06116 1271864012111 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1271864012112 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864012113 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1271864012114 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1271864012115 active site 1271864012116 homodimer interface [polypeptide binding]; other site 1271864012117 homotetramer interface [polypeptide binding]; other site 1271864012118 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1271864012119 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1271864012120 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1271864012121 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864012122 substrate binding site [chemical binding]; other site 1271864012123 ATP binding site [chemical binding]; other site 1271864012124 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1271864012125 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1271864012126 putative active site [active] 1271864012127 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1271864012128 dimer interface [polypeptide binding]; other site 1271864012129 active site 1271864012130 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1271864012131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864012132 DNA-binding site [nucleotide binding]; DNA binding site 1271864012133 UTRA domain; Region: UTRA; pfam07702 1271864012134 trehalase; Provisional; Region: treF; PRK13270 1271864012135 Trehalase; Region: Trehalase; pfam01204 1271864012136 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 1271864012137 catalytic residue [active] 1271864012138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1271864012139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1271864012140 active site 1271864012141 phosphorylation site [posttranslational modification] 1271864012142 dimerization interface [polypeptide binding]; other site 1271864012143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864012144 DNA binding residues [nucleotide binding] 1271864012145 dimerization interface [polypeptide binding]; other site 1271864012146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864012147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864012148 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1271864012149 putative effector binding pocket; other site 1271864012150 putative dimerization interface [polypeptide binding]; other site 1271864012151 inner membrane protein YhjD; Region: TIGR00766 1271864012152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012153 metabolite-proton symporter; Region: 2A0106; TIGR00883 1271864012154 putative substrate translocation pore; other site 1271864012155 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1271864012156 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1271864012157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864012158 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864012159 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1271864012160 substrate binding site [chemical binding]; other site 1271864012161 ATP binding site [chemical binding]; other site 1271864012162 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1271864012163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1271864012164 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1271864012165 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1271864012166 putative diguanylate cyclase; Provisional; Region: PRK13561 1271864012167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1271864012168 metal binding site [ion binding]; metal-binding site 1271864012169 active site 1271864012170 I-site; other site 1271864012171 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864012172 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1271864012173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1271864012174 TPR motif; other site 1271864012175 binding surface 1271864012176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1271864012177 binding surface 1271864012178 TPR motif; other site 1271864012179 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1271864012180 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1271864012181 cellulose synthase regulator protein; Provisional; Region: PRK11114 1271864012182 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1271864012183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864012184 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1271864012185 DXD motif; other site 1271864012186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864012187 PilZ domain; Region: PilZ; pfam07238 1271864012188 cell division protein; Provisional; Region: PRK10037 1271864012189 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1271864012190 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1271864012191 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1271864012192 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1271864012193 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 1271864012194 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1271864012195 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1271864012196 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1271864012197 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1271864012198 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1271864012199 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1271864012200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864012201 Walker A/P-loop; other site 1271864012202 ATP binding site [chemical binding]; other site 1271864012203 Q-loop/lid; other site 1271864012204 ABC transporter signature motif; other site 1271864012205 Walker B; other site 1271864012206 D-loop; other site 1271864012207 H-loop/switch region; other site 1271864012208 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1271864012209 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1271864012210 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1271864012211 Walker A/P-loop; other site 1271864012212 ATP binding site [chemical binding]; other site 1271864012213 Q-loop/lid; other site 1271864012214 ABC transporter signature motif; other site 1271864012215 Walker B; other site 1271864012216 D-loop; other site 1271864012217 H-loop/switch region; other site 1271864012218 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1271864012219 dipeptide transporter; Provisional; Region: PRK10913 1271864012220 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1271864012221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864012222 dimer interface [polypeptide binding]; other site 1271864012223 conserved gate region; other site 1271864012224 putative PBP binding loops; other site 1271864012225 ABC-ATPase subunit interface; other site 1271864012226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1271864012227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864012228 dimer interface [polypeptide binding]; other site 1271864012229 conserved gate region; other site 1271864012230 putative PBP binding loops; other site 1271864012231 ABC-ATPase subunit interface; other site 1271864012232 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1271864012233 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1271864012234 peptide binding site [polypeptide binding]; other site 1271864012235 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1271864012236 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1271864012237 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1271864012238 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864012239 DNA binding site [nucleotide binding] 1271864012240 domain linker motif; other site 1271864012241 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 1271864012242 putative dimerization interface [polypeptide binding]; other site 1271864012243 putative ligand binding site [chemical binding]; other site 1271864012244 phosphoethanolamine transferase; Provisional; Region: PRK11560 1271864012245 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1271864012246 Sulfatase; Region: Sulfatase; pfam00884 1271864012247 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 1271864012248 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 1271864012249 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 1271864012250 PapC N-terminal domain; Region: PapC_N; pfam13954 1271864012251 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1271864012252 PapC C-terminal domain; Region: PapC_C; pfam13953 1271864012253 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1271864012254 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1271864012255 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1271864012256 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 1271864012257 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1271864012258 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1271864012259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864012260 Coenzyme A binding pocket [chemical binding]; other site 1271864012261 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1271864012262 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1271864012263 molybdopterin cofactor binding site [chemical binding]; other site 1271864012264 substrate binding site [chemical binding]; other site 1271864012265 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1271864012266 molybdopterin cofactor binding site; other site 1271864012267 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1271864012268 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1271864012269 ligand binding site [chemical binding]; other site 1271864012270 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1271864012271 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1271864012272 dimerization interface [polypeptide binding]; other site 1271864012273 ligand binding site [chemical binding]; other site 1271864012274 NADP binding site [chemical binding]; other site 1271864012275 catalytic site [active] 1271864012276 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1271864012277 Predicted transcriptional regulator [Transcription]; Region: COG2944 1271864012278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864012279 salt bridge; other site 1271864012280 non-specific DNA binding site [nucleotide binding]; other site 1271864012281 sequence-specific DNA binding site [nucleotide binding]; other site 1271864012282 cspA; Derived by automated computational analysis using gene prediction method: cmsearch. 1271864012283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1271864012284 DNA-binding site [nucleotide binding]; DNA binding site 1271864012285 RNA-binding motif; other site 1271864012286 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1271864012287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1271864012288 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1271864012289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864012290 Coenzyme A binding pocket [chemical binding]; other site 1271864012291 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1271864012292 DALR anticodon binding domain; Region: DALR_1; pfam05746 1271864012293 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1271864012294 dimer interface [polypeptide binding]; other site 1271864012295 motif 1; other site 1271864012296 active site 1271864012297 motif 2; other site 1271864012298 motif 3; other site 1271864012299 YsaB-like lipoprotein; Region: YsaB; pfam13983 1271864012300 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1271864012301 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1271864012302 Predicted membrane protein [Function unknown]; Region: COG4682 1271864012303 yiaA/B two helix domain; Region: YiaAB; cl01759 1271864012304 yiaA/B two helix domain; Region: YiaAB; cl01759 1271864012305 xylulokinase; Provisional; Region: PRK15027 1271864012306 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1271864012307 N- and C-terminal domain interface [polypeptide binding]; other site 1271864012308 active site 1271864012309 MgATP binding site [chemical binding]; other site 1271864012310 catalytic site [active] 1271864012311 metal binding site [ion binding]; metal-binding site 1271864012312 xylulose binding site [chemical binding]; other site 1271864012313 homodimer interface [polypeptide binding]; other site 1271864012314 xylose isomerase; Provisional; Region: PRK05474 1271864012315 xylose isomerase; Region: xylose_isom_A; TIGR02630 1271864012316 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1271864012317 putative dimerization interface [polypeptide binding]; other site 1271864012318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1271864012319 putative ligand binding site [chemical binding]; other site 1271864012320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864012321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864012322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864012323 hypothetical protein; Provisional; Region: PRK10356 1271864012324 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1271864012325 alpha-amylase; Reviewed; Region: malS; PRK09505 1271864012326 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1271864012327 active site 1271864012328 catalytic site [active] 1271864012329 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1271864012330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1271864012331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864012332 homodimer interface [polypeptide binding]; other site 1271864012333 catalytic residue [active] 1271864012334 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1271864012335 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1271864012336 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1271864012337 Bacterial transcriptional regulator; Region: IclR; pfam01614 1271864012338 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1271864012339 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1271864012340 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1271864012341 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1271864012342 DctM-like transporters; Region: DctM; pfam06808 1271864012343 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1271864012344 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1271864012345 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1271864012346 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1271864012347 putative N- and C-terminal domain interface [polypeptide binding]; other site 1271864012348 putative active site [active] 1271864012349 MgATP binding site [chemical binding]; other site 1271864012350 catalytic site [active] 1271864012351 metal binding site [ion binding]; metal-binding site 1271864012352 putative xylulose binding site [chemical binding]; other site 1271864012353 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1271864012354 active site 1271864012355 dimer interface [polypeptide binding]; other site 1271864012356 magnesium binding site [ion binding]; other site 1271864012357 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1271864012358 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1271864012359 AP (apurinic/apyrimidinic) site pocket; other site 1271864012360 DNA interaction; other site 1271864012361 Metal-binding active site; metal-binding site 1271864012362 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1271864012363 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1271864012364 intersubunit interface [polypeptide binding]; other site 1271864012365 active site 1271864012366 Zn2+ binding site [ion binding]; other site 1271864012367 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1271864012368 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1271864012369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864012370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1271864012371 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1271864012372 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1271864012373 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1271864012374 NAD(P) binding site [chemical binding]; other site 1271864012375 catalytic residues [active] 1271864012376 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1271864012377 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1271864012378 nucleotide binding site [chemical binding]; other site 1271864012379 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1271864012380 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1271864012381 G1 box; other site 1271864012382 putative GEF interaction site [polypeptide binding]; other site 1271864012383 GTP/Mg2+ binding site [chemical binding]; other site 1271864012384 Switch I region; other site 1271864012385 G2 box; other site 1271864012386 G3 box; other site 1271864012387 Switch II region; other site 1271864012388 G4 box; other site 1271864012389 G5 box; other site 1271864012390 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1271864012391 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1271864012392 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1271864012393 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1271864012394 selenocysteine synthase; Provisional; Region: PRK04311 1271864012395 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1271864012396 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1271864012397 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864012398 catalytic residue [active] 1271864012399 putative glutathione S-transferase; Provisional; Region: PRK10357 1271864012400 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1271864012401 putative C-terminal domain interface [polypeptide binding]; other site 1271864012402 putative GSH binding site (G-site) [chemical binding]; other site 1271864012403 putative dimer interface [polypeptide binding]; other site 1271864012404 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1271864012405 dimer interface [polypeptide binding]; other site 1271864012406 N-terminal domain interface [polypeptide binding]; other site 1271864012407 putative substrate binding pocket (H-site) [chemical binding]; other site 1271864012408 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1271864012409 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1271864012410 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1271864012411 active site 1271864012412 P-loop; other site 1271864012413 phosphorylation site [posttranslational modification] 1271864012414 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864012415 active site 1271864012416 phosphorylation site [posttranslational modification] 1271864012417 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1271864012418 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1271864012419 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1271864012420 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1271864012421 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1271864012422 hypothetical protein; Provisional; Region: PRK11020 1271864012423 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1271864012424 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1271864012425 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1271864012426 trimer interface [polypeptide binding]; other site 1271864012427 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1271864012428 Haemagglutinin; Region: HIM; pfam05662 1271864012429 Haemagglutinin; Region: HIM; pfam05662 1271864012430 YadA-like C-terminal region; Region: YadA; pfam03895 1271864012431 L-lactate permease; Provisional; Region: PRK10420 1271864012432 glycolate transporter; Provisional; Region: PRK09695 1271864012433 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1271864012434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864012435 DNA-binding site [nucleotide binding]; DNA binding site 1271864012436 FCD domain; Region: FCD; pfam07729 1271864012437 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1271864012438 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1271864012439 active site 1271864012440 substrate binding site [chemical binding]; other site 1271864012441 FMN binding site [chemical binding]; other site 1271864012442 putative catalytic residues [active] 1271864012443 putative rRNA methylase; Provisional; Region: PRK10358 1271864012444 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1271864012445 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864012446 DNA binding site [nucleotide binding] 1271864012447 domain linker motif; other site 1271864012448 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1271864012449 putative dimerization interface [polypeptide binding]; other site 1271864012450 putative ligand binding site [chemical binding]; other site 1271864012451 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1271864012452 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1271864012453 active site pocket [active] 1271864012454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012455 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864012456 putative substrate translocation pore; other site 1271864012457 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1271864012458 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1271864012459 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1271864012460 trimer interface [polypeptide binding]; other site 1271864012461 active site 1271864012462 substrate binding site [chemical binding]; other site 1271864012463 CoA binding site [chemical binding]; other site 1271864012464 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1271864012465 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1271864012466 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1271864012467 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1271864012468 SecA binding site; other site 1271864012469 Preprotein binding site; other site 1271864012470 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1271864012471 GSH binding site [chemical binding]; other site 1271864012472 catalytic residues [active] 1271864012473 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1271864012474 active site residue [active] 1271864012475 phosphoglyceromutase; Provisional; Region: PRK05434 1271864012476 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1271864012477 AmiB activator; Provisional; Region: PRK11637 1271864012478 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1271864012479 Peptidase family M23; Region: Peptidase_M23; pfam01551 1271864012480 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1271864012481 NodB motif; other site 1271864012482 putative active site [active] 1271864012483 putative catalytic site [active] 1271864012484 Zn binding site [ion binding]; other site 1271864012485 putative glycosyl transferase; Provisional; Region: PRK10073 1271864012486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1271864012487 active site 1271864012488 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1271864012489 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1271864012490 NAD(P) binding site [chemical binding]; other site 1271864012491 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1271864012492 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1271864012493 substrate-cofactor binding pocket; other site 1271864012494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864012495 catalytic residue [active] 1271864012496 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1271864012497 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1271864012498 NADP binding site [chemical binding]; other site 1271864012499 homopentamer interface [polypeptide binding]; other site 1271864012500 substrate binding site [chemical binding]; other site 1271864012501 active site 1271864012502 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1271864012503 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1271864012504 putative active site [active] 1271864012505 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1271864012506 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1271864012507 putative active site [active] 1271864012508 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1271864012509 O-antigen ligase RfaL; Provisional; Region: PRK15487 1271864012510 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1271864012511 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1271864012512 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1271864012513 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1271864012514 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1271864012515 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1271864012516 Ligand binding site; other site 1271864012517 metal-binding site 1271864012518 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1271864012519 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1271864012520 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1271864012521 Ligand binding site; other site 1271864012522 metal-binding site 1271864012523 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1271864012524 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1271864012525 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1271864012526 putative ADP-binding pocket [chemical binding]; other site 1271864012527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864012528 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1271864012529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1271864012530 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1271864012531 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1271864012532 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1271864012533 putative active site [active] 1271864012534 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1271864012535 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1271864012536 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1271864012537 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1271864012538 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1271864012539 active site 1271864012540 (T/H)XGH motif; other site 1271864012541 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1271864012542 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1271864012543 DNA binding site [nucleotide binding] 1271864012544 catalytic residue [active] 1271864012545 H2TH interface [polypeptide binding]; other site 1271864012546 putative catalytic residues [active] 1271864012547 turnover-facilitating residue; other site 1271864012548 intercalation triad [nucleotide binding]; other site 1271864012549 8OG recognition residue [nucleotide binding]; other site 1271864012550 putative reading head residues; other site 1271864012551 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1271864012552 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1271864012553 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1271864012554 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1271864012555 hypothetical protein; Reviewed; Region: PRK00024 1271864012556 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1271864012557 MPN+ (JAMM) motif; other site 1271864012558 Zinc-binding site [ion binding]; other site 1271864012559 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1271864012560 Flavoprotein; Region: Flavoprotein; pfam02441 1271864012561 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1271864012562 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1271864012563 trimer interface [polypeptide binding]; other site 1271864012564 active site 1271864012565 division inhibitor protein; Provisional; Region: slmA; PRK09480 1271864012566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864012567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1271864012568 active site 1271864012569 ribonuclease PH; Reviewed; Region: rph; PRK00173 1271864012570 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1271864012571 hexamer interface [polypeptide binding]; other site 1271864012572 active site 1271864012573 hypothetical protein; Provisional; Region: PRK11820 1271864012574 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1271864012575 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1271864012576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864012577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864012578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1271864012579 dimerization interface [polypeptide binding]; other site 1271864012580 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1271864012581 Predicted membrane protein [Function unknown]; Region: COG2860 1271864012582 UPF0126 domain; Region: UPF0126; pfam03458 1271864012583 UPF0126 domain; Region: UPF0126; pfam03458 1271864012584 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1271864012585 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1271864012586 nucleotide binding pocket [chemical binding]; other site 1271864012587 K-X-D-G motif; other site 1271864012588 catalytic site [active] 1271864012589 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1271864012590 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1271864012591 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1271864012592 catalytic site [active] 1271864012593 G-X2-G-X-G-K; other site 1271864012594 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1271864012595 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1271864012596 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1271864012597 Zn2+ binding site [ion binding]; other site 1271864012598 Mg2+ binding site [ion binding]; other site 1271864012599 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1271864012600 synthetase active site [active] 1271864012601 NTP binding site [chemical binding]; other site 1271864012602 metal binding site [ion binding]; metal-binding site 1271864012603 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1271864012604 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1271864012605 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1271864012606 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1271864012607 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1271864012608 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1271864012609 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1271864012610 generic binding surface II; other site 1271864012611 ssDNA binding site; other site 1271864012612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864012613 ATP binding site [chemical binding]; other site 1271864012614 putative Mg++ binding site [ion binding]; other site 1271864012615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864012616 nucleotide binding region [chemical binding]; other site 1271864012617 ATP-binding site [chemical binding]; other site 1271864012618 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1271864012619 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1271864012620 AsmA family; Region: AsmA; pfam05170 1271864012621 putative alpha-glucosidase; Provisional; Region: PRK10658 1271864012622 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1271864012623 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1271864012624 active site 1271864012625 homotrimer interface [polypeptide binding]; other site 1271864012626 catalytic site [active] 1271864012627 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1271864012628 putative transporter; Provisional; Region: PRK11462 1271864012629 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1271864012630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864012631 AAA domain; Region: AAA_23; pfam13476 1271864012632 Walker A/P-loop; other site 1271864012633 ATP binding site [chemical binding]; other site 1271864012634 AAA domain; Region: AAA_21; pfam13304 1271864012635 Virulence protein [General function prediction only]; Region: COG3943 1271864012636 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1271864012637 autotransport protein MisL; Provisional; Region: PRK15313 1271864012638 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1271864012639 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1271864012640 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1271864012641 DNA binding site [nucleotide binding] 1271864012642 Isochorismatase family; Region: Isochorismatase; pfam00857 1271864012643 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1271864012644 catalytic triad [active] 1271864012645 dimer interface [polypeptide binding]; other site 1271864012646 conserved cis-peptide bond; other site 1271864012647 magnesium-transporting ATPase; Provisional; Region: PRK15122 1271864012648 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1271864012649 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1271864012650 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1271864012651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864012652 motif II; other site 1271864012653 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1271864012654 magnesium transport protein MgtC; Provisional; Region: PRK15385 1271864012655 MgtC family; Region: MgtC; pfam02308 1271864012656 EamA-like transporter family; Region: EamA; pfam00892 1271864012657 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1271864012658 EamA-like transporter family; Region: EamA; pfam00892 1271864012659 hypothetical protein; Provisional; Region: PRK09956 1271864012660 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1271864012661 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1271864012662 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1271864012663 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 1271864012664 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1271864012665 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1271864012666 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1271864012667 active site 1271864012668 phosphorylation site [posttranslational modification] 1271864012669 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1271864012670 active pocket/dimerization site; other site 1271864012671 active site 1271864012672 phosphorylation site [posttranslational modification] 1271864012673 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1271864012674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864012675 Walker A motif; other site 1271864012676 ATP binding site [chemical binding]; other site 1271864012677 Walker B motif; other site 1271864012678 arginine finger; other site 1271864012679 Transcriptional antiterminator [Transcription]; Region: COG3933 1271864012680 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1271864012681 active site 1271864012682 active pocket/dimerization site; other site 1271864012683 phosphorylation site [posttranslational modification] 1271864012684 PRD domain; Region: PRD; pfam00874 1271864012685 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1271864012686 beta-galactosidase; Region: BGL; TIGR03356 1271864012687 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1271864012688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012689 putative substrate translocation pore; other site 1271864012690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1271864012691 Predicted transcriptional regulator [Transcription]; Region: COG2944 1271864012692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864012693 non-specific DNA binding site [nucleotide binding]; other site 1271864012694 salt bridge; other site 1271864012695 sequence-specific DNA binding site [nucleotide binding]; other site 1271864012696 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1271864012697 dimerization domain swap beta strand [polypeptide binding]; other site 1271864012698 regulatory protein interface [polypeptide binding]; other site 1271864012699 active site 1271864012700 regulatory phosphorylation site [posttranslational modification]; other site 1271864012701 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1271864012702 intersubunit interface [polypeptide binding]; other site 1271864012703 active site 1271864012704 zinc binding site [ion binding]; other site 1271864012705 Na+ binding site [ion binding]; other site 1271864012706 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1271864012707 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1271864012708 putative N- and C-terminal domain interface [polypeptide binding]; other site 1271864012709 putative active site [active] 1271864012710 putative MgATP binding site [chemical binding]; other site 1271864012711 catalytic site [active] 1271864012712 metal binding site [ion binding]; metal-binding site 1271864012713 putative carbohydrate binding site [chemical binding]; other site 1271864012714 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1271864012715 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1271864012716 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1271864012717 active site 1271864012718 P-loop; other site 1271864012719 phosphorylation site [posttranslational modification] 1271864012720 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1271864012721 active site 1271864012722 phosphorylation site [posttranslational modification] 1271864012723 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1271864012724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864012725 DNA-binding site [nucleotide binding]; DNA binding site 1271864012726 UTRA domain; Region: UTRA; pfam07702 1271864012727 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1271864012728 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1271864012729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012730 putative substrate translocation pore; other site 1271864012731 regulatory protein UhpC; Provisional; Region: PRK11663 1271864012732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012733 putative substrate translocation pore; other site 1271864012734 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1271864012735 MASE1; Region: MASE1; pfam05231 1271864012736 Histidine kinase; Region: HisKA_3; pfam07730 1271864012737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864012738 ATP binding site [chemical binding]; other site 1271864012739 Mg2+ binding site [ion binding]; other site 1271864012740 G-X-G motif; other site 1271864012741 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1271864012742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864012743 active site 1271864012744 phosphorylation site [posttranslational modification] 1271864012745 intermolecular recognition site; other site 1271864012746 dimerization interface [polypeptide binding]; other site 1271864012747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1271864012748 DNA binding residues [nucleotide binding] 1271864012749 dimerization interface [polypeptide binding]; other site 1271864012750 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1271864012751 active site 1271864012752 catalytic residues [active] 1271864012753 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1271864012754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012755 putative substrate translocation pore; other site 1271864012756 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864012757 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1271864012758 substrate binding site [chemical binding]; other site 1271864012759 dimer interface [polypeptide binding]; other site 1271864012760 ATP binding site [chemical binding]; other site 1271864012761 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1271864012762 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1271864012763 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864012764 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1271864012765 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1271864012766 putative valine binding site [chemical binding]; other site 1271864012767 dimer interface [polypeptide binding]; other site 1271864012768 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1271864012769 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1271864012770 PYR/PP interface [polypeptide binding]; other site 1271864012771 dimer interface [polypeptide binding]; other site 1271864012772 TPP binding site [chemical binding]; other site 1271864012773 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1271864012774 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1271864012775 TPP-binding site [chemical binding]; other site 1271864012776 dimer interface [polypeptide binding]; other site 1271864012777 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1271864012778 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1271864012779 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1271864012780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012781 putative substrate translocation pore; other site 1271864012782 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1271864012783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864012784 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1271864012785 dimerization interface [polypeptide binding]; other site 1271864012786 substrate binding pocket [chemical binding]; other site 1271864012787 permease DsdX; Provisional; Region: PRK09921 1271864012788 gluconate transporter; Region: gntP; TIGR00791 1271864012789 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1271864012790 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1271864012791 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1271864012792 catalytic residue [active] 1271864012793 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1271864012794 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1271864012795 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1271864012796 Predicted membrane protein [Function unknown]; Region: COG2149 1271864012797 putative transporter; Validated; Region: PRK03818 1271864012798 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1271864012799 TrkA-C domain; Region: TrkA_C; pfam02080 1271864012800 TrkA-C domain; Region: TrkA_C; pfam02080 1271864012801 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1271864012802 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1271864012803 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1271864012804 putative dimer interface [polypeptide binding]; other site 1271864012805 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1271864012806 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1271864012807 putative dimer interface [polypeptide binding]; other site 1271864012808 hypothetical protein; Provisional; Region: PRK11616 1271864012809 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1271864012810 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1271864012811 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1271864012812 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1271864012813 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1271864012814 catalytic residues [active] 1271864012815 central insert; other site 1271864012816 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1271864012817 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1271864012818 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1271864012819 heme exporter protein CcmC; Region: ccmC; TIGR01191 1271864012820 heme exporter protein CcmB; Region: ccmB; TIGR01190 1271864012821 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1271864012822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864012823 Walker A/P-loop; other site 1271864012824 ATP binding site [chemical binding]; other site 1271864012825 Q-loop/lid; other site 1271864012826 ABC transporter signature motif; other site 1271864012827 Walker B; other site 1271864012828 D-loop; other site 1271864012829 H-loop/switch region; other site 1271864012830 Haem-binding domain; Region: Haem_bd; pfam14376 1271864012831 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1271864012832 chaperone protein TorD; Validated; Region: torD; PRK04976 1271864012833 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1271864012834 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1271864012835 molybdopterin cofactor binding site [chemical binding]; other site 1271864012836 substrate binding site [chemical binding]; other site 1271864012837 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1271864012838 molybdopterin cofactor binding site; other site 1271864012839 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1271864012840 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1271864012841 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1271864012842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864012843 active site 1271864012844 phosphorylation site [posttranslational modification] 1271864012845 intermolecular recognition site; other site 1271864012846 dimerization interface [polypeptide binding]; other site 1271864012847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864012848 DNA binding site [nucleotide binding] 1271864012849 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1271864012850 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1271864012851 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1271864012852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864012853 dimer interface [polypeptide binding]; other site 1271864012854 phosphorylation site [posttranslational modification] 1271864012855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864012856 ATP binding site [chemical binding]; other site 1271864012857 Mg2+ binding site [ion binding]; other site 1271864012858 G-X-G motif; other site 1271864012859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864012860 active site 1271864012861 phosphorylation site [posttranslational modification] 1271864012862 intermolecular recognition site; other site 1271864012863 dimerization interface [polypeptide binding]; other site 1271864012864 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1271864012865 putative binding surface; other site 1271864012866 active site 1271864012867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012868 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864012869 putative substrate translocation pore; other site 1271864012870 galactonate dehydratase; Provisional; Region: PRK14017 1271864012871 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1271864012872 putative active site pocket [active] 1271864012873 putative metal binding site [ion binding]; other site 1271864012874 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1271864012875 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1271864012876 active site 1271864012877 intersubunit interface [polypeptide binding]; other site 1271864012878 catalytic residue [active] 1271864012879 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1271864012880 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1271864012881 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1271864012882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864012883 DNA-binding site [nucleotide binding]; DNA binding site 1271864012884 FCD domain; Region: FCD; pfam07729 1271864012885 sugar phosphate phosphatase; Provisional; Region: PRK10513 1271864012886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864012887 active site 1271864012888 motif I; other site 1271864012889 motif II; other site 1271864012890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864012891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012892 D-galactonate transporter; Region: 2A0114; TIGR00893 1271864012893 putative substrate translocation pore; other site 1271864012894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012895 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1271864012896 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1271864012897 active site pocket [active] 1271864012898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1271864012899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864012900 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1271864012901 putative dimerization interface [polypeptide binding]; other site 1271864012902 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1271864012903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864012904 Mg2+ binding site [ion binding]; other site 1271864012905 G-X-G motif; other site 1271864012906 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1271864012907 anchoring element; other site 1271864012908 dimer interface [polypeptide binding]; other site 1271864012909 ATP binding site [chemical binding]; other site 1271864012910 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1271864012911 active site 1271864012912 putative metal-binding site [ion binding]; other site 1271864012913 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1271864012914 recF protein; Region: recf; TIGR00611 1271864012915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864012916 Walker A/P-loop; other site 1271864012917 ATP binding site [chemical binding]; other site 1271864012918 Q-loop/lid; other site 1271864012919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1271864012920 ABC transporter signature motif; other site 1271864012921 Walker B; other site 1271864012922 D-loop; other site 1271864012923 H-loop/switch region; other site 1271864012924 DNA polymerase III subunit beta; Validated; Region: PRK05643 1271864012925 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1271864012926 putative DNA binding surface [nucleotide binding]; other site 1271864012927 dimer interface [polypeptide binding]; other site 1271864012928 beta-clamp/clamp loader binding surface; other site 1271864012929 beta-clamp/translesion DNA polymerase binding surface; other site 1271864012930 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1271864012931 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1271864012932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864012933 Walker A motif; other site 1271864012934 ATP binding site [chemical binding]; other site 1271864012935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1271864012936 Walker B motif; other site 1271864012937 arginine finger; other site 1271864012938 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1271864012939 DnaA box-binding interface [nucleotide binding]; other site 1271864012940 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1271864012941 membrane protein insertase; Provisional; Region: PRK01318 1271864012942 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1271864012943 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1271864012944 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1271864012945 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1271864012946 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1271864012947 G1 box; other site 1271864012948 GTP/Mg2+ binding site [chemical binding]; other site 1271864012949 Switch I region; other site 1271864012950 G2 box; other site 1271864012951 Switch II region; other site 1271864012952 G3 box; other site 1271864012953 G4 box; other site 1271864012954 G5 box; other site 1271864012955 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1271864012956 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1271864012957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864012958 putative substrate translocation pore; other site 1271864012959 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1271864012960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864012961 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1271864012962 substrate binding pocket [chemical binding]; other site 1271864012963 dimerization interface [polypeptide binding]; other site 1271864012964 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1271864012965 Predicted flavoprotein [General function prediction only]; Region: COG0431 1271864012966 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1271864012967 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1271864012968 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1271864012969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864012970 active site 1271864012971 motif I; other site 1271864012972 motif II; other site 1271864012973 transcriptional regulator PhoU; Provisional; Region: PRK11115 1271864012974 PhoU domain; Region: PhoU; pfam01895 1271864012975 PhoU domain; Region: PhoU; pfam01895 1271864012976 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1271864012977 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1271864012978 Walker A/P-loop; other site 1271864012979 ATP binding site [chemical binding]; other site 1271864012980 Q-loop/lid; other site 1271864012981 ABC transporter signature motif; other site 1271864012982 Walker B; other site 1271864012983 D-loop; other site 1271864012984 H-loop/switch region; other site 1271864012985 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1271864012986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864012987 dimer interface [polypeptide binding]; other site 1271864012988 conserved gate region; other site 1271864012989 putative PBP binding loops; other site 1271864012990 ABC-ATPase subunit interface; other site 1271864012991 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1271864012992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1271864012993 dimer interface [polypeptide binding]; other site 1271864012994 conserved gate region; other site 1271864012995 putative PBP binding loops; other site 1271864012996 ABC-ATPase subunit interface; other site 1271864012997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864012998 substrate binding pocket [chemical binding]; other site 1271864012999 membrane-bound complex binding site; other site 1271864013000 hinge residues; other site 1271864013001 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1271864013002 active site 1271864013003 P-loop; other site 1271864013004 phosphorylation site [posttranslational modification] 1271864013005 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1271864013006 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1271864013007 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1271864013008 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1271864013009 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1271864013010 shikimate binding site; other site 1271864013011 NAD(P) binding site [chemical binding]; other site 1271864013012 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1271864013013 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1271864013014 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1271864013015 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1271864013016 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1271864013017 glutaminase active site [active] 1271864013018 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1271864013019 dimer interface [polypeptide binding]; other site 1271864013020 active site 1271864013021 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1271864013022 dimer interface [polypeptide binding]; other site 1271864013023 active site 1271864013024 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1271864013025 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1271864013026 Substrate binding site; other site 1271864013027 Mg++ binding site; other site 1271864013028 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1271864013029 active site 1271864013030 substrate binding site [chemical binding]; other site 1271864013031 CoA binding site [chemical binding]; other site 1271864013032 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1271864013033 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1271864013034 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1271864013035 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1271864013036 gamma subunit interface [polypeptide binding]; other site 1271864013037 epsilon subunit interface [polypeptide binding]; other site 1271864013038 LBP interface [polypeptide binding]; other site 1271864013039 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1271864013040 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1271864013041 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1271864013042 alpha subunit interaction interface [polypeptide binding]; other site 1271864013043 Walker A motif; other site 1271864013044 ATP binding site [chemical binding]; other site 1271864013045 Walker B motif; other site 1271864013046 inhibitor binding site; inhibition site 1271864013047 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1271864013048 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1271864013049 core domain interface [polypeptide binding]; other site 1271864013050 delta subunit interface [polypeptide binding]; other site 1271864013051 epsilon subunit interface [polypeptide binding]; other site 1271864013052 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1271864013053 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1271864013054 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1271864013055 beta subunit interaction interface [polypeptide binding]; other site 1271864013056 Walker A motif; other site 1271864013057 ATP binding site [chemical binding]; other site 1271864013058 Walker B motif; other site 1271864013059 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1271864013060 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1271864013061 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1271864013062 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1271864013063 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1271864013064 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1271864013065 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1271864013066 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1271864013067 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1271864013068 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1271864013069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864013070 S-adenosylmethionine binding site [chemical binding]; other site 1271864013071 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1271864013072 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1271864013073 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1271864013074 FMN-binding protein MioC; Provisional; Region: PRK09004 1271864013075 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1271864013076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864013077 putative DNA binding site [nucleotide binding]; other site 1271864013078 putative Zn2+ binding site [ion binding]; other site 1271864013079 AsnC family; Region: AsnC_trans_reg; pfam01037 1271864013080 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1271864013081 dimer interface [polypeptide binding]; other site 1271864013082 active site 1271864013083 hypothetical protein; Provisional; Region: yieM; PRK10997 1271864013084 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1271864013085 metal ion-dependent adhesion site (MIDAS); other site 1271864013086 regulatory ATPase RavA; Provisional; Region: PRK13531 1271864013087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864013088 Walker A motif; other site 1271864013089 ATP binding site [chemical binding]; other site 1271864013090 Walker B motif; other site 1271864013091 arginine finger; other site 1271864013092 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1271864013093 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1271864013094 potassium uptake protein; Region: kup; TIGR00794 1271864013095 D-ribose pyranase; Provisional; Region: PRK11797 1271864013096 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1271864013097 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1271864013098 Walker A/P-loop; other site 1271864013099 ATP binding site [chemical binding]; other site 1271864013100 Q-loop/lid; other site 1271864013101 ABC transporter signature motif; other site 1271864013102 Walker B; other site 1271864013103 D-loop; other site 1271864013104 H-loop/switch region; other site 1271864013105 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1271864013106 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1271864013107 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1271864013108 TM-ABC transporter signature motif; other site 1271864013109 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1271864013110 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1271864013111 ligand binding site [chemical binding]; other site 1271864013112 dimerization interface [polypeptide binding]; other site 1271864013113 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864013114 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1271864013115 substrate binding site [chemical binding]; other site 1271864013116 dimer interface [polypeptide binding]; other site 1271864013117 ATP binding site [chemical binding]; other site 1271864013118 transcriptional repressor RbsR; Provisional; Region: PRK10423 1271864013119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864013120 DNA binding site [nucleotide binding] 1271864013121 domain linker motif; other site 1271864013122 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1271864013123 dimerization interface [polypeptide binding]; other site 1271864013124 ligand binding site [chemical binding]; other site 1271864013125 putative transporter; Provisional; Region: PRK10504 1271864013126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864013127 putative substrate translocation pore; other site 1271864013128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864013129 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1271864013130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864013131 DNA-binding site [nucleotide binding]; DNA binding site 1271864013132 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1271864013133 transcriptional regulator HdfR; Provisional; Region: PRK03601 1271864013134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864013135 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1271864013136 dimerization interface [polypeptide binding]; other site 1271864013137 hypothetical protein; Provisional; Region: PRK11027 1271864013138 putative ATP-dependent protease; Provisional; Region: PRK09862 1271864013139 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1271864013140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864013141 Walker A motif; other site 1271864013142 ATP binding site [chemical binding]; other site 1271864013143 Walker B motif; other site 1271864013144 arginine finger; other site 1271864013145 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1271864013146 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1271864013147 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1271864013148 PYR/PP interface [polypeptide binding]; other site 1271864013149 dimer interface [polypeptide binding]; other site 1271864013150 TPP binding site [chemical binding]; other site 1271864013151 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1271864013152 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1271864013153 TPP-binding site [chemical binding]; other site 1271864013154 dimer interface [polypeptide binding]; other site 1271864013155 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1271864013156 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1271864013157 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1271864013158 homodimer interface [polypeptide binding]; other site 1271864013159 substrate-cofactor binding pocket; other site 1271864013160 catalytic residue [active] 1271864013161 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1271864013162 threonine dehydratase; Reviewed; Region: PRK09224 1271864013163 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1271864013164 tetramer interface [polypeptide binding]; other site 1271864013165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864013166 catalytic residue [active] 1271864013167 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1271864013168 putative Ile/Val binding site [chemical binding]; other site 1271864013169 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1271864013170 putative Ile/Val binding site [chemical binding]; other site 1271864013171 Phage-related protein [Function unknown]; Region: COG4679 1271864013172 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1271864013173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864013174 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1271864013175 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1271864013176 putative dimerization interface [polypeptide binding]; other site 1271864013177 ketol-acid reductoisomerase; Validated; Region: PRK05225 1271864013178 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1271864013179 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1271864013180 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1271864013181 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1271864013182 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1271864013183 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1271864013184 Part of AAA domain; Region: AAA_19; pfam13245 1271864013185 Family description; Region: UvrD_C_2; pfam13538 1271864013186 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1271864013187 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1271864013188 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1271864013189 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1271864013190 ATP binding site [chemical binding]; other site 1271864013191 Mg++ binding site [ion binding]; other site 1271864013192 motif III; other site 1271864013193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864013194 nucleotide binding region [chemical binding]; other site 1271864013195 ATP-binding site [chemical binding]; other site 1271864013196 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1271864013197 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1271864013198 catalytic residues [active] 1271864013199 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1271864013200 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1271864013201 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1271864013202 RNA binding site [nucleotide binding]; other site 1271864013203 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1271864013204 multimer interface [polypeptide binding]; other site 1271864013205 Walker A motif; other site 1271864013206 ATP binding site [chemical binding]; other site 1271864013207 Walker B motif; other site 1271864013208 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1271864013209 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1271864013210 Mg++ binding site [ion binding]; other site 1271864013211 putative catalytic motif [active] 1271864013212 substrate binding site [chemical binding]; other site 1271864013213 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1271864013214 Chain length determinant protein; Region: Wzz; pfam02706 1271864013215 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1271864013216 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1271864013217 active site 1271864013218 homodimer interface [polypeptide binding]; other site 1271864013219 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1271864013220 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1271864013221 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1271864013222 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1271864013223 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1271864013224 NAD binding site [chemical binding]; other site 1271864013225 substrate binding site [chemical binding]; other site 1271864013226 homodimer interface [polypeptide binding]; other site 1271864013227 active site 1271864013228 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1271864013229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1271864013230 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1271864013231 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1271864013232 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1271864013233 inhibitor-cofactor binding pocket; inhibition site 1271864013234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864013235 catalytic residue [active] 1271864013236 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1271864013237 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1271864013238 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1271864013239 putative common antigen polymerase; Provisional; Region: PRK02975 1271864013240 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1271864013241 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1271864013242 putative transport protein YifK; Provisional; Region: PRK10746 1271864013243 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1271864013244 HemY protein N-terminus; Region: HemY_N; pfam07219 1271864013245 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1271864013246 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1271864013247 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1271864013248 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1271864013249 active site 1271864013250 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1271864013251 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1271864013252 domain interfaces; other site 1271864013253 active site 1271864013254 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1271864013255 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1271864013256 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1271864013257 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1271864013258 putative iron binding site [ion binding]; other site 1271864013259 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1271864013260 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1271864013261 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1271864013262 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1271864013263 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1271864013264 hypothetical protein; Provisional; Region: PRK10963 1271864013265 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1271864013266 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1271864013267 active site 1271864013268 Int/Topo IB signature motif; other site 1271864013269 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1271864013270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864013271 motif II; other site 1271864013272 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1271864013273 Part of AAA domain; Region: AAA_19; pfam13245 1271864013274 Family description; Region: UvrD_C_2; pfam13538 1271864013275 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1271864013276 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1271864013277 Cl binding site [ion binding]; other site 1271864013278 oligomer interface [polypeptide binding]; other site 1271864013279 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1271864013280 EamA-like transporter family; Region: EamA; cl17759 1271864013281 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1271864013282 CoenzymeA binding site [chemical binding]; other site 1271864013283 subunit interaction site [polypeptide binding]; other site 1271864013284 PHB binding site; other site 1271864013285 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1271864013286 dimerization interface [polypeptide binding]; other site 1271864013287 substrate binding site [chemical binding]; other site 1271864013288 active site 1271864013289 calcium binding site [ion binding]; other site 1271864013290 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1271864013291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864013292 ATP binding site [chemical binding]; other site 1271864013293 putative Mg++ binding site [ion binding]; other site 1271864013294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1271864013295 nucleotide binding region [chemical binding]; other site 1271864013296 ATP-binding site [chemical binding]; other site 1271864013297 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1271864013298 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1271864013299 threonine efflux system; Provisional; Region: PRK10229 1271864013300 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1271864013301 lysophospholipase L2; Provisional; Region: PRK10749 1271864013302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1271864013303 putative hydrolase; Provisional; Region: PRK10976 1271864013304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864013305 active site 1271864013306 motif I; other site 1271864013307 motif II; other site 1271864013308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864013309 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1271864013310 EamA-like transporter family; Region: EamA; pfam00892 1271864013311 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1271864013312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864013313 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1271864013314 putative dimerization interface [polypeptide binding]; other site 1271864013315 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1271864013316 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1271864013317 THF binding site; other site 1271864013318 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1271864013319 substrate binding site [chemical binding]; other site 1271864013320 THF binding site; other site 1271864013321 zinc-binding site [ion binding]; other site 1271864013322 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1271864013323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864013324 FeS/SAM binding site; other site 1271864013325 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1271864013326 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1271864013327 uridine phosphorylase; Provisional; Region: PRK11178 1271864013328 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1271864013329 DNA recombination protein RmuC; Provisional; Region: PRK10361 1271864013330 RmuC family; Region: RmuC; pfam02646 1271864013331 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1271864013332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864013333 S-adenosylmethionine binding site [chemical binding]; other site 1271864013334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1271864013335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1271864013336 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1271864013337 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1271864013338 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1271864013339 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1271864013340 sec-independent translocase; Provisional; Region: PRK01770 1271864013341 sec-independent translocase; Provisional; Region: tatB; PRK00404 1271864013342 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1271864013343 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1271864013344 active site 1271864013345 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1271864013346 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1271864013347 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1271864013348 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1271864013349 FMN reductase; Validated; Region: fre; PRK08051 1271864013350 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1271864013351 FAD binding pocket [chemical binding]; other site 1271864013352 FAD binding motif [chemical binding]; other site 1271864013353 phosphate binding motif [ion binding]; other site 1271864013354 beta-alpha-beta structure motif; other site 1271864013355 NAD binding pocket [chemical binding]; other site 1271864013356 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1271864013357 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1271864013358 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1271864013359 dimer interface [polypeptide binding]; other site 1271864013360 active site 1271864013361 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1271864013362 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1271864013363 substrate binding site [chemical binding]; other site 1271864013364 oxyanion hole (OAH) forming residues; other site 1271864013365 trimer interface [polypeptide binding]; other site 1271864013366 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1271864013367 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1271864013368 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1271864013369 proline dipeptidase; Provisional; Region: PRK13607 1271864013370 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1271864013371 active site 1271864013372 hypothetical protein; Provisional; Region: PRK11568 1271864013373 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1271864013374 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1271864013375 potassium transporter; Provisional; Region: PRK10750 1271864013376 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1271864013377 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1271864013378 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1271864013379 Walker A motif; other site 1271864013380 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1271864013381 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1271864013382 GTP binding site; other site 1271864013383 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1271864013384 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1271864013385 serine/threonine protein kinase; Provisional; Region: PRK11768 1271864013386 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1271864013387 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1271864013388 catalytic residues [active] 1271864013389 hinge region; other site 1271864013390 alpha helical domain; other site 1271864013391 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1271864013392 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1271864013393 putative acyl-acceptor binding pocket; other site 1271864013394 DNA polymerase I; Provisional; Region: PRK05755 1271864013395 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1271864013396 active site 1271864013397 metal binding site 1 [ion binding]; metal-binding site 1271864013398 putative 5' ssDNA interaction site; other site 1271864013399 metal binding site 3; metal-binding site 1271864013400 metal binding site 2 [ion binding]; metal-binding site 1271864013401 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1271864013402 putative DNA binding site [nucleotide binding]; other site 1271864013403 putative metal binding site [ion binding]; other site 1271864013404 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1271864013405 active site 1271864013406 catalytic site [active] 1271864013407 substrate binding site [chemical binding]; other site 1271864013408 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1271864013409 active site 1271864013410 DNA binding site [nucleotide binding] 1271864013411 catalytic site [active] 1271864013412 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1271864013413 G1 box; other site 1271864013414 GTP/Mg2+ binding site [chemical binding]; other site 1271864013415 Switch I region; other site 1271864013416 G2 box; other site 1271864013417 G3 box; other site 1271864013418 Switch II region; other site 1271864013419 G4 box; other site 1271864013420 G5 box; other site 1271864013421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1271864013422 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1271864013423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1271864013424 FeS/SAM binding site; other site 1271864013425 HemN C-terminal domain; Region: HemN_C; pfam06969 1271864013426 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1271864013427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864013428 active site 1271864013429 phosphorylation site [posttranslational modification] 1271864013430 intermolecular recognition site; other site 1271864013431 dimerization interface [polypeptide binding]; other site 1271864013432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864013433 Walker A motif; other site 1271864013434 ATP binding site [chemical binding]; other site 1271864013435 Walker B motif; other site 1271864013436 arginine finger; other site 1271864013437 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1271864013438 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1271864013439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1271864013440 putative active site [active] 1271864013441 heme pocket [chemical binding]; other site 1271864013442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864013443 dimer interface [polypeptide binding]; other site 1271864013444 phosphorylation site [posttranslational modification] 1271864013445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864013446 ATP binding site [chemical binding]; other site 1271864013447 Mg2+ binding site [ion binding]; other site 1271864013448 G-X-G motif; other site 1271864013449 glutamine synthetase; Provisional; Region: glnA; PRK09469 1271864013450 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1271864013451 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1271864013452 GTP-binding protein; Provisional; Region: PRK10218 1271864013453 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1271864013454 G1 box; other site 1271864013455 putative GEF interaction site [polypeptide binding]; other site 1271864013456 GTP/Mg2+ binding site [chemical binding]; other site 1271864013457 Switch I region; other site 1271864013458 G2 box; other site 1271864013459 G3 box; other site 1271864013460 Switch II region; other site 1271864013461 G4 box; other site 1271864013462 G5 box; other site 1271864013463 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1271864013464 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1271864013465 outer membrane porin L; Provisional; Region: ompL; PRK09980 1271864013466 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1271864013467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864013468 putative substrate translocation pore; other site 1271864013469 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1271864013470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1271864013471 putative substrate translocation pore; other site 1271864013472 alpha-glucosidase; Provisional; Region: PRK10426 1271864013473 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1271864013474 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1271864013475 putative active site [active] 1271864013476 putative catalytic site [active] 1271864013477 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1271864013478 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1271864013479 active site 1271864013480 catalytic residues [active] 1271864013481 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1271864013482 dimerization interface [polypeptide binding]; other site 1271864013483 putative active cleft [active] 1271864013484 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1271864013485 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1271864013486 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1271864013487 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864013488 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1271864013489 substrate binding site [chemical binding]; other site 1271864013490 ATP binding site [chemical binding]; other site 1271864013491 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1271864013492 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1271864013493 putative DNA binding site [nucleotide binding]; other site 1271864013494 putative Zn2+ binding site [ion binding]; other site 1271864013495 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1271864013496 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1271864013497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1271864013498 motif II; other site 1271864013499 hypothetical protein; Reviewed; Region: PRK01637 1271864013500 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1271864013501 putative active site [active] 1271864013502 dimerization interface [polypeptide binding]; other site 1271864013503 putative tRNAtyr binding site [nucleotide binding]; other site 1271864013504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864013505 Coenzyme A binding pocket [chemical binding]; other site 1271864013506 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1271864013507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864013508 non-specific DNA binding site [nucleotide binding]; other site 1271864013509 salt bridge; other site 1271864013510 sequence-specific DNA binding site [nucleotide binding]; other site 1271864013511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1271864013512 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1271864013513 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1271864013514 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1271864013515 Predicted transcriptional regulator [Transcription]; Region: COG2944 1271864013516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864013517 non-specific DNA binding site [nucleotide binding]; other site 1271864013518 salt bridge; other site 1271864013519 sequence-specific DNA binding site [nucleotide binding]; other site 1271864013520 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1271864013521 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1271864013522 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1271864013523 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1271864013524 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1271864013525 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1271864013526 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864013527 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1271864013528 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1271864013529 molybdopterin cofactor binding site; other site 1271864013530 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1271864013531 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1271864013532 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1271864013533 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1271864013534 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1271864013535 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1271864013536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1271864013537 non-specific DNA binding site [nucleotide binding]; other site 1271864013538 salt bridge; other site 1271864013539 sequence-specific DNA binding site [nucleotide binding]; other site 1271864013540 Cupin domain; Region: Cupin_2; cl17218 1271864013541 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1271864013542 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1271864013543 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1271864013544 dimer interface [polypeptide binding]; other site 1271864013545 active site 1271864013546 metal binding site [ion binding]; metal-binding site 1271864013547 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1271864013548 intersubunit interface [polypeptide binding]; other site 1271864013549 active site 1271864013550 Zn2+ binding site [ion binding]; other site 1271864013551 L-rhamnose isomerase; Provisional; Region: PRK01076 1271864013552 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1271864013553 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1271864013554 N- and C-terminal domain interface [polypeptide binding]; other site 1271864013555 active site 1271864013556 putative catalytic site [active] 1271864013557 metal binding site [ion binding]; metal-binding site 1271864013558 ATP binding site [chemical binding]; other site 1271864013559 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1271864013560 carbohydrate binding site [chemical binding]; other site 1271864013561 transcriptional activator RhaS; Provisional; Region: PRK13503 1271864013562 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1271864013563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864013564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864013565 transcriptional activator RhaR; Provisional; Region: PRK13502 1271864013566 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1271864013567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864013568 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 1271864013569 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1271864013570 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1271864013571 DctM-like transporters; Region: DctM; pfam06808 1271864013572 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1271864013573 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1271864013574 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1271864013575 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1271864013576 superoxide dismutase; Provisional; Region: PRK10925 1271864013577 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1271864013578 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1271864013579 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1271864013580 MOSC domain; Region: MOSC; pfam03473 1271864013581 3-alpha domain; Region: 3-alpha; pfam03475 1271864013582 SnoaL-like domain; Region: SnoaL_2; pfam12680 1271864013583 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1271864013584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1271864013585 dimerization interface [polypeptide binding]; other site 1271864013586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1271864013587 dimer interface [polypeptide binding]; other site 1271864013588 phosphorylation site [posttranslational modification] 1271864013589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1271864013590 ATP binding site [chemical binding]; other site 1271864013591 Mg2+ binding site [ion binding]; other site 1271864013592 G-X-G motif; other site 1271864013593 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1271864013594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1271864013595 active site 1271864013596 intermolecular recognition site; other site 1271864013597 dimerization interface [polypeptide binding]; other site 1271864013598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1271864013599 DNA binding site [nucleotide binding] 1271864013600 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1271864013601 dimer interface [polypeptide binding]; other site 1271864013602 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1271864013603 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1271864013604 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1271864013605 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1271864013606 active site 1271864013607 ADP/pyrophosphate binding site [chemical binding]; other site 1271864013608 dimerization interface [polypeptide binding]; other site 1271864013609 allosteric effector site; other site 1271864013610 fructose-1,6-bisphosphate binding site; other site 1271864013611 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1271864013612 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1271864013613 substrate binding pocket [chemical binding]; other site 1271864013614 membrane-bound complex binding site; other site 1271864013615 hinge residues; other site 1271864013616 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1271864013617 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1271864013618 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1271864013619 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1271864013620 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1271864013621 putative substrate binding site [chemical binding]; other site 1271864013622 putative ATP binding site [chemical binding]; other site 1271864013623 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1271864013624 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1271864013625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1271864013626 DNA-binding site [nucleotide binding]; DNA binding site 1271864013627 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 1271864013628 UTRA domain; Region: UTRA; pfam07702 1271864013629 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 1271864013630 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1271864013631 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1271864013632 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1271864013633 putative N- and C-terminal domain interface [polypeptide binding]; other site 1271864013634 putative active site [active] 1271864013635 putative MgATP binding site [chemical binding]; other site 1271864013636 catalytic site [active] 1271864013637 metal binding site [ion binding]; metal-binding site 1271864013638 putative carbohydrate binding site [chemical binding]; other site 1271864013639 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1271864013640 transcriptional regulator LsrR; Provisional; Region: PRK15418 1271864013641 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1271864013642 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1271864013643 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1271864013644 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1271864013645 Walker A/P-loop; other site 1271864013646 ATP binding site [chemical binding]; other site 1271864013647 Q-loop/lid; other site 1271864013648 ABC transporter signature motif; other site 1271864013649 Walker B; other site 1271864013650 D-loop; other site 1271864013651 H-loop/switch region; other site 1271864013652 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1271864013653 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1271864013654 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1271864013655 TM-ABC transporter signature motif; other site 1271864013656 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1271864013657 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1271864013658 TM-ABC transporter signature motif; other site 1271864013659 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1271864013660 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1271864013661 ligand binding site [chemical binding]; other site 1271864013662 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1271864013663 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1271864013664 putative active site; other site 1271864013665 catalytic residue [active] 1271864013666 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1271864013667 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1271864013668 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1271864013669 substrate binding site [chemical binding]; other site 1271864013670 hexamer interface [polypeptide binding]; other site 1271864013671 metal binding site [ion binding]; metal-binding site 1271864013672 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1271864013673 triosephosphate isomerase; Provisional; Region: PRK14567 1271864013674 substrate binding site [chemical binding]; other site 1271864013675 dimer interface [polypeptide binding]; other site 1271864013676 catalytic triad [active] 1271864013677 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1271864013678 Predicted membrane protein [Function unknown]; Region: COG3152 1271864013679 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1271864013680 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1271864013681 FAD binding pocket [chemical binding]; other site 1271864013682 FAD binding motif [chemical binding]; other site 1271864013683 phosphate binding motif [ion binding]; other site 1271864013684 beta-alpha-beta structure motif; other site 1271864013685 NAD binding pocket [chemical binding]; other site 1271864013686 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1271864013687 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1271864013688 putative active site [active] 1271864013689 glycerol kinase; Provisional; Region: glpK; PRK00047 1271864013690 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1271864013691 N- and C-terminal domain interface [polypeptide binding]; other site 1271864013692 active site 1271864013693 MgATP binding site [chemical binding]; other site 1271864013694 catalytic site [active] 1271864013695 metal binding site [ion binding]; metal-binding site 1271864013696 glycerol binding site [chemical binding]; other site 1271864013697 homotetramer interface [polypeptide binding]; other site 1271864013698 homodimer interface [polypeptide binding]; other site 1271864013699 FBP binding site [chemical binding]; other site 1271864013700 protein IIAGlc interface [polypeptide binding]; other site 1271864013701 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1271864013702 amphipathic channel; other site 1271864013703 Asn-Pro-Ala signature motifs; other site 1271864013704 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1271864013705 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1271864013706 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1271864013707 UbiA prenyltransferase family; Region: UbiA; pfam01040 1271864013708 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1271864013709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864013710 Walker A motif; other site 1271864013711 ATP binding site [chemical binding]; other site 1271864013712 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1271864013713 Walker B motif; other site 1271864013714 arginine finger; other site 1271864013715 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1271864013716 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1271864013717 active site 1271864013718 HslU subunit interaction site [polypeptide binding]; other site 1271864013719 essential cell division protein FtsN; Provisional; Region: PRK10927 1271864013720 cell division protein FtsN; Provisional; Region: PRK12757 1271864013721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1271864013722 DNA binding site [nucleotide binding] 1271864013723 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1271864013724 domain linker motif; other site 1271864013725 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1271864013726 dimerization interface [polypeptide binding]; other site 1271864013727 ligand binding site [chemical binding]; other site 1271864013728 primosome assembly protein PriA; Validated; Region: PRK05580 1271864013729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864013730 ATP binding site [chemical binding]; other site 1271864013731 putative Mg++ binding site [ion binding]; other site 1271864013732 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1271864013733 ATP-binding site [chemical binding]; other site 1271864013734 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1271864013735 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 1271864013736 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1271864013737 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1271864013738 dimerization interface [polypeptide binding]; other site 1271864013739 DNA binding site [nucleotide binding] 1271864013740 corepressor binding sites; other site 1271864013741 cystathionine gamma-synthase; Provisional; Region: PRK08045 1271864013742 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1271864013743 homodimer interface [polypeptide binding]; other site 1271864013744 substrate-cofactor binding pocket; other site 1271864013745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1271864013746 catalytic residue [active] 1271864013747 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1271864013748 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1271864013749 putative catalytic residues [active] 1271864013750 putative nucleotide binding site [chemical binding]; other site 1271864013751 putative aspartate binding site [chemical binding]; other site 1271864013752 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1271864013753 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1271864013754 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1271864013755 mechanosensitive channel MscS; Provisional; Region: PRK10334 1271864013756 Conserved TM helix; Region: TM_helix; pfam05552 1271864013757 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1271864013758 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1271864013759 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1271864013760 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1271864013761 active site 1271864013762 metal binding site [ion binding]; metal-binding site 1271864013763 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1271864013764 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1271864013765 FAD binding site [chemical binding]; other site 1271864013766 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1271864013767 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1271864013768 heme binding site [chemical binding]; other site 1271864013769 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1271864013770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1271864013771 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1271864013772 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1271864013773 dimer interface [polypeptide binding]; other site 1271864013774 active site 1271864013775 metal binding site [ion binding]; metal-binding site 1271864013776 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1271864013777 active site 1271864013778 intersubunit interactions; other site 1271864013779 catalytic residue [active] 1271864013780 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1271864013781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1271864013782 hypothetical protein; Provisional; Region: PRK10649 1271864013783 Sulfatase; Region: Sulfatase; pfam00884 1271864013784 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1271864013785 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1271864013786 acetylornithine deacetylase; Provisional; Region: PRK05111 1271864013787 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1271864013788 metal binding site [ion binding]; metal-binding site 1271864013789 putative dimer interface [polypeptide binding]; other site 1271864013790 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1271864013791 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1271864013792 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1271864013793 nucleotide binding site [chemical binding]; other site 1271864013794 N-acetyl-L-glutamate binding site [chemical binding]; other site 1271864013795 argininosuccinate lyase; Provisional; Region: PRK04833 1271864013796 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1271864013797 active sites [active] 1271864013798 tetramer interface [polypeptide binding]; other site 1271864013799 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1271864013800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1271864013801 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1271864013802 dimerization interface [polypeptide binding]; other site 1271864013803 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1271864013804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1271864013805 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1271864013806 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1271864013807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1271864013808 hypothetical protein; Provisional; Region: PRK11056 1271864013809 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1271864013810 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 1271864013811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1271864013812 S-adenosylmethionine binding site [chemical binding]; other site 1271864013813 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1271864013814 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1271864013815 N-terminal plug; other site 1271864013816 ligand-binding site [chemical binding]; other site 1271864013817 glutamate racemase; Provisional; Region: PRK00865 1271864013818 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1271864013819 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1271864013820 Type II/IV secretion system protein; Region: T2SE; pfam00437 1271864013821 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1271864013822 Walker A motif; other site 1271864013823 ATP binding site [chemical binding]; other site 1271864013824 Walker B motif; other site 1271864013825 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1271864013826 PilS N terminal; Region: PilS; pfam08805 1271864013827 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1271864013828 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864013829 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864013830 catalytic residue [active] 1271864013831 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1271864013832 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 1271864013833 catalytic residues [active] 1271864013834 Int/Topo IB signature motif; other site 1271864013835 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1271864013836 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1271864013837 catalytic core [active] 1271864013838 plasmid transfer ATPase TraJ; Region: plasmid_TraJ; TIGR02525 1271864013839 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1271864013840 Walker A motif; other site 1271864013841 ATP binding site [chemical binding]; other site 1271864013842 Walker B motif; other site 1271864013843 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 1271864013844 PLD-like domain; Region: PLDc_2; pfam13091 1271864013845 putative active site [active] 1271864013846 catalytic site [active] 1271864013847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1271864013848 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1271864013849 active site 1271864013850 metal binding site [ion binding]; metal-binding site 1271864013851 interdomain interaction site; other site 1271864013852 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 1271864013853 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 1271864013854 AAA-like domain; Region: AAA_10; pfam12846 1271864013855 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1271864013856 HEAT repeats; Region: HEAT_2; pfam13646 1271864013857 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1271864013858 Hok/gef family; Region: HOK_GEF; pfam01848 1271864013859 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1271864013860 dimerization domain [polypeptide binding]; other site 1271864013861 dimer interface [polypeptide binding]; other site 1271864013862 catalytic residues [active] 1271864013863 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1271864013864 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1271864013865 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1271864013866 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1271864013867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1271864013868 non-specific DNA binding site [nucleotide binding]; other site 1271864013869 salt bridge; other site 1271864013870 sequence-specific DNA binding site [nucleotide binding]; other site 1271864013871 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1271864013872 putative transposase; Provisional; Region: PRK09857 1271864013873 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1271864013874 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1271864013875 PsiA protein; Region: PsiA; cl11646 1271864013876 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 1271864013877 ParB-like nuclease domain; Region: ParB; smart00470 1271864013878 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1271864013879 KorB domain; Region: KorB; pfam08535 1271864013880 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1271864013881 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1271864013882 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1271864013883 dimer interface [polypeptide binding]; other site 1271864013884 ssDNA binding site [nucleotide binding]; other site 1271864013885 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1271864013886 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1271864013887 Antirestriction protein; Region: Antirestrict; pfam03230 1271864013888 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 1271864013889 putative methylase; Provisional; Region: PRK13699 1271864013890 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1271864013891 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 1271864013892 DinI-like family; Region: DinI; cl11630 1271864013893 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 1271864013894 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1271864013895 Mg binding site [ion binding]; other site 1271864013896 nucleotide binding site [chemical binding]; other site 1271864013897 putative protofilament interface [polypeptide binding]; other site 1271864013898 ParA-like protein; Provisional; Region: PHA02518 1271864013899 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1271864013900 P-loop; other site 1271864013901 Magnesium ion binding site [ion binding]; other site 1271864013902 Phage integrase family; Region: Phage_integrase; pfam00589 1271864013903 active site 1271864013904 DNA binding site [nucleotide binding] 1271864013905 Int/Topo IB signature motif; other site 1271864013906 Colicin Ia; Region: Colicin_Ia; pfam11504 1271864013907 Colicin pore forming domain; Region: Colicin; pfam01024 1271864013908 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 1271864013909 putative kissing complex interaction region; other site 1271864013910 putative RNA binding sites [nucleotide binding]; other site 1271864013911 Transposase; Region: HTH_Tnp_1; pfam01527 1271864013912 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1271864013913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1271864013914 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1271864013915 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1271864013916 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1271864013917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1271864013918 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1271864013919 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1271864013920 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1271864013921 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1271864013922 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1271864013923 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1271864013924 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1271864013925 catalytic residues [active] 1271864013926 catalytic nucleophile [active] 1271864013927 Presynaptic Site I dimer interface [polypeptide binding]; other site 1271864013928 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1271864013929 Synaptic Flat tetramer interface [polypeptide binding]; other site 1271864013930 Synaptic Site I dimer interface [polypeptide binding]; other site 1271864013931 DNA binding site [nucleotide binding] 1271864013932 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1271864013933 DNA-binding interface [nucleotide binding]; DNA binding site 1271864013934 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1271864013935 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 1271864013936 integrase/recombinase; Provisional; Region: PRK15417 1271864013937 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 1271864013938 Int/Topo IB signature motif; other site 1271864013939 aminoglycoside resistance protein; Provisional; Region: PRK13746 1271864013940 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1271864013941 active site 1271864013942 NTP binding site [chemical binding]; other site 1271864013943 metal binding triad [ion binding]; metal-binding site 1271864013944 antibiotic binding site [chemical binding]; other site 1271864013945 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1271864013946 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1271864013947 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1271864013948 oligomerisation interface [polypeptide binding]; other site 1271864013949 mobile loop; other site 1271864013950 roof hairpin; other site 1271864013951 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1271864013952 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1271864013953 ring oligomerisation interface [polypeptide binding]; other site 1271864013954 ATP/Mg binding site [chemical binding]; other site 1271864013955 stacking interactions; other site 1271864013956 hinge regions; other site 1271864013957 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1271864013958 Putative transposase; Region: Y2_Tnp; pfam04986 1271864013959 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1271864013960 MULE transposase domain; Region: MULE; pfam10551 1271864013961 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1271864013962 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1271864013963 dihydropteroate synthase; Region: DHPS; TIGR01496 1271864013964 substrate binding pocket [chemical binding]; other site 1271864013965 dimer interface [polypeptide binding]; other site 1271864013966 inhibitor binding site; inhibition site 1271864013967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1271864013968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1271864013969 Coenzyme A binding pocket [chemical binding]; other site 1271864013970 transposase/IS protein; Provisional; Region: PRK09183 1271864013971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1271864013972 Walker A motif; other site 1271864013973 ATP binding site [chemical binding]; other site 1271864013974 Walker B motif; other site 1271864013975 arginine finger; other site 1271864013976 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1271864013977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1271864013978 Integrase core domain; Region: rve; pfam00665 1271864013979 Bacterial TniB protein; Region: TniB; pfam05621 1271864013980 Integrase core domain; Region: rve; pfam00665 1271864013981 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1271864013982 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1271864013983 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1271864013984 active site 1271864013985 catalytic site [active] 1271864013986 substrate binding site [chemical binding]; other site 1271864013987 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1271864013988 Predicted transcriptional regulator [Transcription]; Region: COG3905 1271864013989 IncFII RepA protein family; Region: IncFII_repA; cl11495 1271864013990 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1271864013991 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 1271864013992 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 1271864013993 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 1271864013994 Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623 1271864013995 PilM; Region: PilM; pfam07419 1271864013996 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1271864013997 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 1271864013998 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1271864013999 Initiator Replication protein; Region: Rep_3; pfam01051 1271864014000 ParA-like protein; Provisional; Region: PHA02518 1271864014001 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1271864014002 P-loop; other site 1271864014003 Magnesium ion binding site [ion binding]; other site 1271864014004 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1271864014005 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 1271864014006 catalytic residues [active] 1271864014007 catalytic nucleophile [active] 1271864014008 Homeodomain-like domain; Region: HTH_23; cl17451 1271864014009 AAA domain; Region: AAA_21; pfam13304 1271864014010 Superfamily II helicase [General function prediction only]; Region: COG1204 1271864014011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1271864014012 ATP binding site [chemical binding]; other site 1271864014013 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1271864014014 Winged helix-turn helix; Region: HTH_29; pfam13551 1271864014015 Helix-turn-helix domain; Region: HTH_28; pfam13518 1271864014016 Integrase core domain; Region: rve_3; pfam13683 1271864014017 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1271864014018 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1271864014019 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1271864014020 DNA topoisomerase III; Provisional; Region: PRK07726 1271864014021 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1271864014022 active site 1271864014023 putative interdomain interaction site [polypeptide binding]; other site 1271864014024 putative metal-binding site [ion binding]; other site 1271864014025 putative nucleotide binding site [chemical binding]; other site 1271864014026 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1271864014027 domain I; other site 1271864014028 DNA binding groove [nucleotide binding] 1271864014029 phosphate binding site [ion binding]; other site 1271864014030 domain II; other site 1271864014031 domain III; other site 1271864014032 nucleotide binding site [chemical binding]; other site 1271864014033 catalytic site [active] 1271864014034 domain IV; other site 1271864014035 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1271864014036 TrbM; Region: TrbM; pfam07424 1271864014037 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 1271864014038 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1271864014039 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1271864014040 Walker A motif; other site 1271864014041 ATP binding site [chemical binding]; other site 1271864014042 Walker B motif; other site 1271864014043 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1271864014044 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1271864014045 ATP binding site [chemical binding]; other site 1271864014046 Walker A motif; other site 1271864014047 hexamer interface [polypeptide binding]; other site 1271864014048 Walker B motif; other site 1271864014049 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1271864014050 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1271864014051 VirB7 interaction site; other site 1271864014052 VirB8 protein; Region: VirB8; pfam04335 1271864014053 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1271864014054 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 1271864014055 Type IV secretion system proteins; Region: T4SS; pfam07996 1271864014056 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1271864014057 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1271864014058 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1271864014059 TrbC/VIRB2 family; Region: TrbC; pfam04956 1271864014060 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1271864014061 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1271864014062 catalytic residue [active] 1271864014063 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432