-- dump date 20111121_014520 -- class Genbank::CDS -- table cds_note -- id note YP_001569097.1 KEGG: stm:STM2961 8.8e-243 ygcY; putative D-glucarate dehydratase K01706; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001569098.1 KEGG: sec:SC2900 8.7e-236 gudD; D-glucarate dehydratase K01706; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: vesicles of secretory system, score: 9 YP_001569099.1 KEGG: stt:t2868 3.3e-188 glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001569100.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_001569101.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001569102.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_001569103.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001569104.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001569105.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001569106.1 COG: NOG04673 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569107.1 Psort location: cytoplasmic, score: 23 YP_001569108.1 KEGG: hpa:HPAG1_0914 8.5e-06 hypothetical protein K04071; COG: COG0602 Organic radical activating enzymes; Psort location: cytoplasmic, score: 23 YP_001569109.1 KEGG: sty:STY3077 4.5e-65 6-pyruvoyltetrahydropterin synthase K01737; COG: COG0720 6-pyruvoyl-tetrahydropterin synthase; Psort location: cytoplasmic, score: 23 YP_001569110.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_001569111.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_001569112.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001569113.1 COG: NOG25864 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569114.1 Psort location: cytoplasmic, score: 23 YP_001569115.1 COG: COG1203 Predicted helicases; Psort location: cytoplasmic, score: 23 YP_001569116.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_001569117.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001569118.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_001569119.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_001569120.1 COG: NOG12170 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569121.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_001569122.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001569123.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001569124.1 catalyzes the modification of U13 in tRNA(Glu) YP_001569125.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001569126.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_001569127.1 Psort location: nuclear, score: 23 YP_001569128.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_001569129.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_001569130.1 COG: NOG14130 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569131.1 KEGG: gvi:gll3010 3.8e-52 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD K03182; COG: COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Psort location: cytoplasmic, score: 23 YP_001569132.1 KEGG: sec:SC2851 1.2e-96 pad; putative flavoprotein K03186; COG: COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase; Psort location: mitochondrial, score: 23 YP_001569133.1 COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001569134.1 KEGG: shn:Shewana3_3435 1.1e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569135.1 KEGG: ani:AN1180.2 2.4e-05 hypothetical protein K04428; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001569136.1 COG: COG4460 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569137.1 This protein performs the mismatch recognition step during the DNA repair process YP_001569138.1 COG: NOG29516 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569139.1 KEGG: nwi:Nwi_1143 1.4e-08 helix-turn-helix, fis-type K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569140.1 COG: COG4644 Transposase and inactivated derivatives, TnpA family; Psort location: mitochondrial, score: 23 YP_001569141.1 COG: COG4644 Transposase and inactivated derivatives, TnpA family; Psort location: cytoplasmic, score: 23 YP_001569142.1 COG: COG4644 Transposase and inactivated derivatives, TnpA family; Psort location: cytoplasmic, score: 23 YP_001569143.1 COG: COG1961 Site-specific recombinases, DNA invertase Pin homologs; Psort location: cytoplasmic, score: 23 YP_001569144.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569145.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569146.1 COG: NOG18468 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001569147.1 COG: NOG18467 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569148.1 Psort location: cytoplasmic, score: 23 YP_001569149.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001569150.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001569151.1 Psort location: cytoplasmic, score: 23 YP_001569152.1 Psort location: cytoplasmic, score: 23 YP_001569153.1 Psort location: endoplasmic reticulum, score: 9 YP_001569154.1 COG: NOG11501 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569155.1 COG: NOG27628 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569156.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001569157.1 Psort location: extracellular, including cell wall, score: 9 YP_001569158.1 KEGG: pen:PSEEN5483 4.6e-11 lipase K01066; COG: COG3675 Predicted lipase; Psort location: cytoplasmic, score: 23 YP_001569159.1 KEGG: pol:Bpro_3660 5.2e-05 ribonuclease, Rne/Rng family K08300; Psort location: nuclear, score: 23 YP_001569160.1 Psort location: extracellular, including cell wall, score: 9 YP_001569161.1 Psort location: cytoskeletal, score: 9 YP_001569162.1 Psort location: nuclear, score: 23 YP_001569163.1 COG: COG3328 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569164.1 Psort location: extracellular, including cell wall, score: 9 YP_001569165.1 COG: COG3547 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569166.1 COG: COG3547 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001569167.1 Psort location: nuclear, score: 23 YP_001569168.1 COG: NOG28130 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569169.1 COG: NOG14596 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569170.1 COG: COG1450 Type II secretory pathway, component PulD; Psort location: extracellular, including cell wall, score: 9 YP_001569171.1 COG: NOG06182 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569172.1 COG: COG4789 Type III secretory pathway, component EscV; Psort location: plasma membrane, score: 23 YP_001569173.1 COG: NOG14129 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569174.1 Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase YP_001569175.1 KEGG: bta:282041 0.0055 ROCK2; Rho-associated, coiled-coil containing protein kinase 2 K04514; COG: NOG18535 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569176.1 COG: NOG19627 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569177.1 involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells YP_001569178.1 part of a type III secretory system probably involved in invasion into eukaryotic cells YP_001569179.1 COG: COG4794 Type III secretory pathway, component EscS; Psort location: endoplasmic reticulum, score: 9 YP_001569180.1 COG: COG4791 Type III secretory pathway, component EscT; Psort location: endoplasmic reticulum, score: 9 YP_001569181.1 Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins YP_001569182.1 COG: COG0457 FOG: TPR repeat; Psort location: cytoplasmic, score: 23 YP_001569183.1 KEGG: pat:Patl_3134 0.0057 ATP-dependent protease La K01338; COG: NOG06175 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569184.1 COG: NOG10023 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569185.1 COG: NOG06173 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569186.1 KEGG: ddi:DDB0184245 5.8e-05 hypothetical protein K03654; COG: NOG06172 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569187.1 carries the fatty acid chain in fatty acid biosynthesis YP_001569188.1 COG: NOG30285 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569189.1 COG: NOG23656 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569190.1 COG: NOG11499 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569191.1 KEGG: bba:Bd1285 1.8e-07 soluble lytic murein transglycosylase K01238; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001569192.1 Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system YP_001569193.1 KEGG: bli:BL05281 0.0021 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001569194.1 COG: NOG07990 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569195.1 COG: NOG13860 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569196.1 COG: NOG19625 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569197.1 COG: COG4669 Type III secretory pathway, lipoprotein EscJ; Psort location: golgi, score: 9 YP_001569198.1 COG: NOG14693 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569199.1 COG: NOG14128 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001569200.1 COG: NOG23015 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569201.1 COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001569202.1 COG: NOG25264 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569203.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001569204.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001569205.1 KEGG: rru:Rru_A2894 2.6e-85 ABC transporter component K02074; COG: COG1121 ABC-type Mn/Zn transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001569206.1 COG: COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; Psort location: extracellular, including cell wall, score: 9 YP_001569207.1 COG: NOG16835 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569208.1 KEGG: eci:UTI89_C3094 0. fhlA; formate hydrogenlyase transcriptional activator K01768; COG: COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; Psort location: cytoplasmic, score: 23 YP_001569209.1 KEGG: cch:Cag_0556 1.7e-81 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001569210.1 COG: COG0409 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001569211.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_001569212.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_001569213.1 plays a role in hydrogenase nickel cofactor insertion YP_001569214.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_001569215.1 KEGG: eci:UTI89_C3087 5.8e-88 hycB; formate hydrogenlyase subunit 2; COG: COG1142 Fe-S-cluster-containing hydrogenase components 2; Psort location: nuclear, score: 23 YP_001569216.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_001569217.1 KEGG: eci:UTI89_C3085 1.3e-145 hycD; membrane-spanning protein of formate hydrogenase; COG: COG0650 Formate hydrogenlyase subunit 4; Psort location: plasma membrane, score: 23 YP_001569218.1 KEGG: eci:UTI89_C3084 0. hycE; formate hydrogenlyase subunit 5 precursor; COG: COG3261 Ni,Fe-hydrogenase III large subunit; Psort location: cytoplasmic, score: 23 YP_001569219.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_001569220.1 KEGG: eci:UTI89_C3082 1.4e-132 hycG; formate hydrogenlyase subunit 7; COG: COG3260 Ni,Fe-hydrogenase III small subunit; Psort location: cytoplasmic, score: 23 YP_001569221.1 KEGG: eci:UTI89_C3081 2.2e-63 hycH; formate hydrogenlyase maturation protein HycH; COG: NOG09848 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569222.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_001569223.1 involved in electron transport from formate to hydrogen YP_001569224.1 KEGG: msu:MS0845 3.5e-06 acyP; acylphosphatases K01512; COG: COG0068 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001569225.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_001569226.1 detoxifies nitric oxide using NADH YP_001569227.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_001569228.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_001569229.1 regulates genes involved in glucitol utilization YP_001569230.1 Psort location: nuclear, score: 23 YP_001569231.1 regulator for glucitol utilization YP_001569232.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_001569233.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001569234.1 KEGG: sty:STY2954 7.6e-166 srlE; PTS system, glucitol/sorbitol-specific IIBC component K02782:K02783; COG: COG3732 Phosphotransferase system sorbitol-specific component IIBC; Psort location: endoplasmic reticulum, score: 9 YP_001569235.1 KEGG: sec:SC2765 1.0e-97 srlA; PTS family, glucitol/sorbitol-specific enzyme IIC component,one of two IIC components K02782:K02783; COG: COG3730 Phosphotransferase system sorbitol-specific component IIC; Psort location: plasma membrane, score: 23 YP_001569236.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_001569237.1 COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: cytoplasmic, score: 23 YP_001569238.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001569239.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001569240.1 Psort location: cytoplasmic, score: 23 YP_001569241.1 KEGG: stm:STM2827 0. alaS; alanyl-tRNA synthetase K01872; COG: COG0013 Alanyl-tRNA synthetase; Psort location: cytoplasmic, score: 23 YP_001569242.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001569243.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_001569244.1 COG: COG1238 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001569245.1 involved in the first step of glutathione biosynthesis YP_001569246.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001569247.1 KEGG: sgl:SG1466 5.5e-07 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001569248.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: golgi, score: 9 YP_001569249.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_001569250.1 KEGG: shn:Shewana3_1692 6.3e-17 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001569251.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_001569252.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_001569253.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_001569254.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001569255.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001569256.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001569257.1 KEGG: vfi:VFA1040 0.00024 glutaredoxin K00435; COG: COG0695 Glutaredoxin and related proteins; Psort location: cytoplasmic, score: 23 YP_001569258.1 COG: COG4575 Uncharacterized conserved protein; Psort location: vesicles of secretory system, score: 23 YP_001569259.1 COG: NOG09772 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001569260.1 COG: NOG11269 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569261.1 Psort location: nuclear, score: 23 YP_001569262.1 COG: COG2916 DNA-binding protein H-NS; Psort location: mitochondrial, score: 23 YP_001569263.1 COG: NOG35541 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569264.1 KEGG: reh:H16_A0333 7.1e-12 rhodanese-related sulfurtransferase; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: endoplasmic reticulum, score: 9 YP_001569265.1 KEGG: reh:H16_A2208 2.8e-06 rhodanese-like: transcriptional regulator, ArsR family; COG: COG0640 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001569266.1 COG: COG0401 Uncharacterized homolog of Blt101; Psort location: cytoplasmic, score: 23 YP_001569267.1 COG: COG1652 Uncharacterized protein containing LysM domain; Psort location: cytoplasmic, score: 23 YP_001569268.1 regulator of gab gene expression YP_001569269.1 KEGG: eci:UTI89_C0120 1.3e-69 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001569270.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001569271.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_001569272.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_001569273.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution YP_001569274.1 Psort location: cytoplasmic, score: 23 YP_001569275.1 Psort location: mitochondrial, score: 23 YP_001569276.1 KEGG: psp:PSPPH_3121 0.0014 nuoN; NADH-quinone oxidoreductase, N subunit K00343; COG: COG3333 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001569277.1 COG: NOG11450 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569278.1 COG: COG3181 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001569279.1 KEGG: rha:RHA1_ro05622 6.2e-36 response regulator (protein-glutamate methylesterase) K07669; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001569280.1 KEGG: stm:STM2784 1.7e-241 tctE; tricarboxylic transport: regulatory protein K07649; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001569281.1 COG: COG3376 High-affinity nickel permease; Psort location: endoplasmic reticulum, score: 9 YP_001569282.1 COG: NOG11449 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569283.1 COG: COG2990 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569284.1 Psort location: cytoplasmic, score: 23 YP_001569285.1 KEGG: ana:alr3268 4.1e-09 serine/threonine kinase K08884; COG: COG1357 Uncharacterized low-complexity proteins; Psort location: nuclear, score: 23 YP_001569286.1 Psort location: cytoplasmic, score: 23 YP_001569287.1 Psort location: nuclear, score: 23 YP_001569288.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001569289.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001569290.1 KEGG: btk:BT9727_3479 6.3e-20 possible esterase; COG: COG2819 Predicted hydrolase of the alpha/beta superfamily; Psort location: mitochondrial, score: 23 YP_001569291.1 KEGG: btk:BT9727_2470 2.0e-07 probable esterase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001569292.1 Psort location: cytoplasmic, score: 23 YP_001569293.1 KEGG: fal:FRAAL1741 1.9e-201 putative ABC transporter ATP-binding protein; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: plasma membrane, score: 23 YP_001569294.1 KEGG: eci:UTI89_C1122 2.5e-174 iroB; putative glucosyltransferase K00754; COG: COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase; Psort location: extracellular, including cell wall, score: 9 YP_001569295.1 Psort location: cytoplasmic, score: 23 YP_001569296.1 COG: COG1961 Site-specific recombinases, DNA invertase Pin homologs; Psort location: cytoplasmic, score: 23 YP_001569297.1 Psort location: cytoplasmic, score: 23 YP_001569298.1 COG: NOG26268 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569299.1 COG: NOG04673 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569300.1 COG: NOG04673 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569301.1 KEGG: ehi:68.t00029 3.5e-07 protein phosphatase with leucine-rich repeats K01768; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001569302.1 Psort location: cytoplasmic, score: 23 YP_001569303.1 COG: COG3311 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569304.1 Psort location: cytoskeletal, score: 9 YP_001569305.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001569306.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001569307.1 COG: COG4688 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569308.1 COG: NOG17703 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569309.1 Psort location: nuclear, score: 23 YP_001569310.1 Psort location: extracellular, including cell wall, score: 9 YP_001569311.1 COG: NOG23803 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569312.1 Psort location: nuclear, score: 23 YP_001569313.1 Psort location: endoplasmic reticulum, score: 9 YP_001569314.1 COG: NOG10802 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569315.1 Psort location: nuclear, score: 23 YP_001569316.1 Psort location: mitochondrial, score: 23 YP_001569317.1 KEGG: nph:NP0492A 8.9e-35 mer3_1; ATP-dependent DNA helicase 1 K03726; COG: COG1204 Superfamily II helicase; Psort location: cytoplasmic, score: 23 YP_001569318.1 Psort location: cytoplasmic, score: 23 YP_001569319.1 Psort location: mitochondrial, score: 23 YP_001569320.1 KEGG: fnu:FN1704 1.3e-07 serine protease; COG: COG1752 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001569321.1 Psort location: nuclear, score: 23 YP_001569322.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001569323.1 COG: COG0845 Membrane-fusion protein; Psort location: cytoplasmic, score: 23 YP_001569324.1 KEGG: pen:PSEEN0144 1.1e-95 type I toxin efflux ATP-binding protein; COG: COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain; Psort location: endoplasmic reticulum, score: 9 YP_001569325.1 COG: COG1538 Outer membrane protein; Psort location: nuclear, score: 23 YP_001569326.1 KEGG: chu:CHU_1906 3.9e-51 CHU large protein, possible SAP or adhesin AidA-related K01238; COG: COG5295 Autotransporter adhesin; Psort location: mitochondrial, score: 23 YP_001569327.1 Psort location: endoplasmic reticulum, score: 9 YP_001569328.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001569329.1 KEGG: tfu:Tfu_1222 0.00068 actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554; COG: COG2867 Oligoketide cyclase/lipid transport protein; Psort location: cytoplasmic, score: 23 YP_001569330.1 COG: COG2914 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569331.1 COG: COG2913 Small protein A (tmRNA-binding); Psort location: extracellular, including cell wall, score: 9 YP_001569332.1 KEGG: yps:YPTB0915 3.2e-06 sbcC; putative ATP-dependent dsDNA exonuclease K03546; COG: COG0497 ATPase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001569333.1 KEGG: spt:SPA2542 1.9e-137 yfjB; Probable inorganic polyphosphate/ATP-NAD kinase K00858; COG: COG0061 Predicted sugar kinase; Psort location: cytoplasmic, score: 23 YP_001569334.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001569335.1 KEGG: ece:Z3906m 3.8e-203 yfjD; uncharacterized CBS domain-containing protein K00638; COG: COG4536 Putative Mg2+ and Co2+ transporter CorB; Psort location: endoplasmic reticulum, score: 23 YP_001569336.1 KEGG: sat:SYN_00150 3.3e-05 heme export protein apocytochrome heme-lyase; COG: COG4137 ABC-type uncharacterized transport system, permease component; Psort location: plasma membrane, score: 23 YP_001569337.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_001569338.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001569339.1 Essential for efficient processing of 16S rRNA YP_001569340.1 KEGG: stm:STM2674 6.1e-125 trmD; tRNA (guanine-7-)-methyltransferase K00554; COG: COG0336 tRNA-(guanine-N1)-methyltransferase; Psort location: cytoplasmic, score: 23 YP_001569341.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001569342.1 COG: COG2199 FOG: GGDEF domain; Psort location: nuclear, score: 23; ORF located using Blastx YP_001569343.1 COG: NOG17158 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569344.2 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_001569345.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_001569346.1 KEGG: bme:BMEI1997 2.0e-23 gluconolactonase K01053; COG: COG3386 Gluconolactonase; Psort location: cytoplasmic, score: 23 YP_001569347.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001569348.1 Psort location: nuclear, score: 23 YP_001569349.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_001569350.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_001569351.1 KEGG: sty:STY2851 3.8e-139 sfhB, rluD; ftsH suppressor protein SfhB K06180; COG: COG0564 Pseudouridylate synthases, 23S RNA-specific; Psort location: cytoplasmic, score: 23 YP_001569352.1 COG: COG1496 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001569353.1 KEGG: eci:UTI89_C2925 0. clpB; heat shock protein K03695; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001569354.1 COG: NOG09993 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569355.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001569356.1 COG: COG5544 Predicted periplasmic lipoprotein; Psort location: cytoplasmic, score: 23 YP_001569357.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_001569358.1 KEGG: eci:UTI89_C2907 0. yfiQ; hypothetical protein YfiQ K09181; COG: COG1042 Acyl-CoA synthetase (NDP forming); Psort location: nuclear, score: 23 YP_001569359.1 COG: COG3148 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001569360.1 KEGG: stm:STM2649 1.4e-72 trxC; THIoredoxin 2, redox factor K03672; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001569361.1 KEGG: stt:t0262 1.1e-182 yfiF; putative RNA methyltransferase K03214; COG: COG0566 rRNA methylases; Psort location: cytoplasmic, score: 23 YP_001569362.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001569363.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_001569364.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_001569365.1 KEGG: eci:UTI89_C2897 1.3e-97 yfiC; hypothetical protein YfiC K00599; COG: COG4123 Predicted O-methyltransferase; Psort location: cytoplasmic, score: 23 YP_001569366.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001569367.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001569368.1 COG: COG3073 Negative regulator of sigma E activity; Psort location: nuclear, score: 23 YP_001569369.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_001569370.1 involved in the reduction of the SoxR iron-sulfur cluster YP_001569371.1 Psort location: cytoplasmic, score: 23 YP_001569372.1 Psort location: cytoplasmic, score: 23 YP_001569373.1 COG: NOG18524 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569374.1 Psort location: extracellular, including cell wall, score: 9 YP_001569375.1 KEGG: gga:427844 4.7e-07 LOC427844; similar to leucine-rich repeat kinase 1 K08843; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001569376.1 Psort location: cytoplasmic, score: 23 YP_001569377.1 KEGG: sty:STY2205 3.2e-10 umuC; UmuC protein K03502; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: nuclear, score: 23 YP_001569378.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001569379.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_001569380.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001569381.1 COG: COG1381 Recombinational DNA repair protein (RecF pathway); Psort location: cytoplasmic, score: 23 YP_001569382.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001569383.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001569384.1 KEGG: bte:BTH_II0708 2.0e-06 fdxH; formate dehydrogenase, beta subunit K00124; COG: COG1145 Ferredoxin; Psort location: nuclear, score: 23 YP_001569385.1 KEGG: bte:BTH_I1550 1.0e-22 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001569386.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001569387.1 KEGG: sec:SC2565 3.6e-27 yfeV; putative phosphotransferase system IIB components K02809:K02810; COG: COG1264 Phosphotransferase system IIB components; Psort location: endoplasmic reticulum, score: 9 YP_001569388.1 COG: COG0560 Phosphoserine phosphatase; Psort location: cytoplasmic, score: 23 YP_001569389.1 KEGG: stt:t0289 3.5e-90 yfhC; hypothetical protein K01500; COG: COG0590 Cytosine/adenosine deaminases; Psort location: cytoplasmic, score: 23 YP_001569390.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001569391.1 Psort location: nuclear, score: 23 YP_001569392.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001569393.1 KEGG: sec:SC2559 8.7e-236 yfhK; putative sensory kinase in regulatory system K07711; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001569394.1 COG: NOG06210 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569395.1 KEGG: eci:UTI89_C2502 1.2e-82 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001569396.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_001569397.1 COG: COG3104 Dipeptide/tripeptide permease; Psort location: plasma membrane, score: 23 YP_001569398.1 KEGG: stt:t0297 0. cadA; lysine decarboxylase K01582; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001569399.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein YP_001569400.1 regulates the cadBA operon YP_001569401.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_001569402.1 Psort location: cytoplasmic, score: 23 YP_001569403.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001569404.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_001569405.1 KEGG: spz:M5005_Spy_1664 0.0080 PTS system, mannitol (cryptic)-specific IIA component K00890; COG: COG3711 Transcriptional antiterminator; Psort location: mitochondrial, score: 23 YP_001569406.1 COG: COG3683 ABC-type uncharacterized transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001569407.1 COG: COG2215 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569408.1 KEGG: stt:t0306 4.8e-180 asrC; anaerobic sulfite reductase subunit C K00385; COG: COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits; Psort location: cytoplasmic, score: 23 YP_001569409.1 with AsrAC catalyzes the reduction of sulfite to hydrogen sulfide YP_001569410.1 KEGG: cno:NT01CX_0257 5.9e-79 anaerobic sulfite reductase subunit A K00437; COG: COG1145 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001569411.1 KEGG: spt:SPA0320 1.5e-137 suhB; extragenic suppressor protein SuhB K01092; COG: COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; Psort location: cytoplasmic, score: 23 YP_001569412.1 KEGG: stm:STM2545 5.6e-122 putative rRNA methylase K02533; COG: COG0565 rRNA methylase; Psort location: cytoplasmic, score: 23 YP_001569413.1 regulates the expression of the iscRSUA operon YP_001569414.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001569415.1 KEGG: rxy:Rxyl_1354 9.8e-16 tRNA (5-methylaminomethyl-2-THIouridylate)-methyltransferase K00566; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: cytoplasmic, score: 23 YP_001569416.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_001569417.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001569418.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001569419.1 KEGG: eci:UTI89_C2847 2.2e-56 fdx; ferredoxin, 2Fe-2S K04755; COG: COG0633 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001569420.1 COG: COG2975 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569421.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_001569422.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_001569423.1 Psort location: nuclear, score: 23 YP_001569424.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_001569425.1 COG: COG2373 Large extracellular alpha-helical protein; Psort location: extracellular, including cell wall, score: 9 YP_001569426.1 penicillin-insensitive transglycosylase/transpeptidase YP_001569427.1 KEGG: dsy:DSY0357 3.7e-237 dmsA; putative anaerobic DMSO reductase chain A precursor K00369; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: mitochondrial, score: 23 YP_001569428.1 KEGG: dsy:DSY0356 6.8e-62 dmsB; putative anaerobic DMSO reductase chain B iron-sulfur subunit K00369; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001569429.1 KEGG: dsy:DSY4822 9.4e-33 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001569430.1 KEGG: mth:MTH926 1.5e-08 tungsten formylmethanofuran dehydrogenase, subunit F homolog K00205; COG: COG1145 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001569431.1 Psort location: cytoplasmic, score: 23 YP_001569432.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001569433.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001569434.1 KEGG: bca:BCE_1379 0.0056 odhB; dihydrolipoamide acetyltransferase K00658; COG: COG1426 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001569435.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001569436.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001569437.1 COG: COG2976 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569438.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_001569439.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001569440.1 KEGG: aha:AHA_1764 6.9e-14 ubiquitin ligase sinat5 K01932; COG: NOG17950 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569441.1 COG: NOG18711 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569442.1 KEGG: eca:ECA3211 1.1e-123 prt1; extracellular metalloprotease; COG: COG3227 Zinc metalloprotease (elastase); Psort location: cytoplasmic, score: 23 YP_001569443.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001569444.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001569445.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001569446.1 COG: NOG22997 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569447.1 COG: COG3335 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569448.1 COG: NOG23066 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569449.1 COG: NOG31152 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569450.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569451.1 COG: NOG23217 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569452.1 COG: NOG36091 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569453.1 COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: cytoplasmic, score: 23 YP_001569454.1 KEGG: noc:Noc_2705 0.00024 Sel1-like repeat protein K01467; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: extracellular, including cell wall, score: 9 YP_001569455.1 COG: NOG13900 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569456.1 KEGG: shn:Shewana3_3829 5.3e-23 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: plasma membrane, score: 23 YP_001569457.1 KEGG: sty:STY2743 1.0e-273 ppx; exopolyphosphatase K01514; COG: COG0248 Exopolyphosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001569458.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001569459.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001569460.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001569461.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001569462.1 KEGG: bcz:BCZK0244 1.3e-07 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001569463.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_001569464.1 KEGG: mca:MCA2520 1.2e-32 arsC; arsenate reductase; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: nuclear, score: 23 YP_001569465.1 KEGG: eci:UTI89_C2810 6.6e-238 yfgC; hypothetical protein YfgC precursor; COG: COG4783 Putative Zn-dependent protease, contains TPR repeats; Psort location: mitochondrial, score: 23 YP_001569466.1 KEGG: tbd:Tbd_2668 2.0e-28 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: plasma membrane, score: 23 YP_001569467.1 KEGG: shn:Shewana3_2682 2.6e-60 transcriptional regulator, CdaR K01694; COG: COG3835 Sugar diacid utilization regulator; Psort location: mitochondrial, score: 23 YP_001569468.1 KEGG: eci:UTI89_C3106 6.5e-19 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001569469.1 KEGG: spt:SPA0377 4.9e-194 putative glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001569470.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_001569471.1 KEGG: eci:UTI89_C2806 1.2e-66 gcvR; glycine cleavage system transcriptional repressor K03567; COG: COG2716 Glycine cleavage system regulatory protein; Psort location: cytoplasmic, score: 23 YP_001569472.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001569473.1 COG: COG3317 Uncharacterized lipoprotein; Psort location: golgi, score: 9 YP_001569474.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001569475.1 KEGG: eci:UTI89_C2802 1.4e-134 ypfJ; hypothetical protein; COG: COG2321 Predicted metalloprotease; Psort location: endoplasmic reticulum, score: 9 YP_001569476.1 COG: COG1444 Predicted P-loop ATPase fused to an acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001569477.1 COG: NOG13899 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569478.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001569479.1 KEGG: eci:UTI89_C2797 7.4e-49 yffB; conserved THIoredoxin-like protein; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: cytoplasmic, score: 23 YP_001569480.1 KEGG: eci:UTI89_C2351 3.6e-111 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001569481.1 KEGG: stm:STM2480 2.8e-285 narQ; sensory histidine kinase in two-component regulatory system with NarP ( NarL) K07674; COG: COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; Psort location: endoplasmic reticulum, score: 9 YP_001569482.1 Psort location: mitochondrial, score: 23 YP_001569483.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_001569484.1 KEGG: eci:UTI89_C2793 7.2e-90 yffH; hypothetical protein YffH K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001569485.1 COG: NOG06758 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569486.1 COG: NOG31287 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569487.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001569488.1 KEGG: stm:STM2473 9.0e-163 talA; transaldolase A K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001569489.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001569490.1 KEGG: ecc:c4719 1.3e-264 aslA; arylsulfatase K01130; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: endoplasmic reticulum, score: 9 YP_001569491.1 KEGG: syg:sync_2368 3.1e-25 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001569492.1 KEGG: sat:SYN_00303 0.0048 hydroxyethylTHIazole kinase K00878; COG: COG4810 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001569493.1 KEGG: eci:UTI89_C2785 4.7e-70 eutP; ethanolamine utilization protein EutP K04029; COG: COG4917 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001569494.1 COG: COG4766 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001569495.1 KEGG: stm:STM2467 2.6e-133 eutT; putative cobalamin adenosyltransferase, ethanolamine utilization K04032; COG: COG4812 Ethanolamine utilization cobalamin adenosyltransferase; Psort location: cytoplasmic, score: 23 YP_001569496.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_001569497.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001569498.1 COG: COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001569499.1 KEGG: rru:Rru_A0914 5.4e-101 aldehyde dehydrogenase K04021; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001569500.1 COG: COG4820 Ethanolamine utilization protein, possible chaperonin; Psort location: cytoplasmic, score: 23 YP_001569501.1 KEGG: eci:UTI89_C2777 2.3e-180 eutG, yffV; ethanolamine utilization protein EutG iron-containing alcohol dehydrogenase K04022; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001569502.1 COG: COG3192 Ethanolamine utilization protein; Psort location: plasma membrane, score: 23 YP_001569503.1 ethanolamine utilization protein EutA YP_001569504.1 KEGG: spt:SPA0410 1.3e-241 eutB; ethanolamine ammonia-lyase heavy chain K03735; COG: COG4303 Ethanolamine ammonia-lyase, large subunit; Psort location: cytoplasmic, score: 23 YP_001569505.1 catalyzes the formation of acetaldehyde from ethanolamine YP_001569506.1 COG: COG4816 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001569507.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001569508.1 activates the transcription of the ethanolamine utilization operon YP_001569509.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001569510.1 KEGG: sty:STY2687 1.0e-147 amiA; probable N-acetylmuramoyl-L-alanine amidase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: mitochondrial, score: 23 YP_001569511.1 KEGG: eci:UTI89_C2767 4.7e-70 ypeA; hypothetical protein YpeA K00680; COG: COG0456 Acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001569512.1 COG: NOG08687 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569513.1 COG: NOG06776 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569514.1 KEGG: reh:H16_B0946 1.3e-42 predicted iron-dependent peroxidase K00430; COG: COG2837 Predicted iron-dependent peroxidase; Psort location: cytoplasmic, score: 23 YP_001569515.1 KEGG: oih:OB0667 1.5e-50 beta-lactamase K01467; COG: COG1680 Beta-lactamase class C and other penicillin binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001569516.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component YP_001569517.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001569518.1 Psort location: extracellular, including cell wall, score: 9 YP_001569519.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001569520.1 KEGG: bam:Bamb_0825 3.2e-22 glucokinase K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001569521.1 KEGG: stm:STM2445 6.1e-132 ucpA; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001569522.1 COG: COG4150 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001569523.1 KEGG: syn:sll0739 1.3e-29 modBC; ABC-type molybdate transport system permease/ATP-binding protein K02018; COG: COG0555 ABC-type sulfate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569524.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_001569525.1 KEGG: stt:t0417 2.0e-188 cysA; sulphate transport ATP-binding protein CysA K02045; COG: COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001569526.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_001569527.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_001569528.1 KEGG: nwi:Nwi_0881 2.0e-25 transcriptional regulatory protein GntR family K00825; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: nuclear, score: 23 YP_001569529.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001569530.1 COG: NOG31214 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569531.1 Psort location: extracellular, including cell wall, score: 23 YP_001569532.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_001569533.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_001569534.1 KEGG: bci:BCI_0069 1.5e-32 ptsH; phosphocarrier protein HPr K00890; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001569535.1 Psort location: cytoplasmic, score: 23 YP_001569536.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_001569537.1 KEGG: ret:RHE_CH03674 3.1e-06 hypothetical protein K01954; COG: COG2981 Uncharacterized protein involved in cysteine biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001569538.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_001569539.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001569540.1 KEGG: cmu:TC0823 0.00043 DNA polymerase III, epsilon subunit, putative K02342; COG: COG3530 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569541.1 COG: COG0385 Predicted Na+-dependent transporter; Psort location: endoplasmic reticulum, score: 9 YP_001569542.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001569543.1 COG: NOG09785 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569544.1 KEGG: xfa:XF1823 0.0055 tail-specific protease K03797; COG: NOG09771 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569545.1 KEGG: shn:Shewana3_3829 6.7e-23 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 23 YP_001569546.1 COG: COG1972 Nucleoside permease; Psort location: endoplasmic reticulum, score: 9 YP_001569547.1 COG: COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; Psort location: plasma membrane, score: 23 YP_001569548.1 KEGG: vpa:VP2751 0.00021 penicillin-binding protein 1A K05366; COG: NOG09770 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569549.1 KEGG: ret:RHE_CH02454 5.5e-108 probable oxidoreductase protein K05882; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001569550.1 KEGG: stm:STM2405 2.6e-284 indolepyruvate decarboxylase K01568; COG: COG3961 Pyruvate decarboxylase and related THIamine pyrophosphate-requiring enzymes; Psort location: cytoplasmic, score: 23 YP_001569551.1 KEGG: cpr:CPR_1400 1.4e-09 chloride channel protein K01529; COG: COG0038 Chloride channel protein EriC; Psort location: plasma membrane, score: 23 YP_001569552.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_001569553.1 KEGG: sbo:SBO_2413 5.8e-49 putative PTS system enzyme IIB component K02769; COG: COG1445 Phosphotransferase system fructose-specific component IIB; Psort location: extracellular, including cell wall, score: 23 YP_001569554.1 KEGG: ecc:c2925 3.1e-201 putative PTS system IIC component ypdG K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: plasma membrane, score: 23 YP_001569555.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase YP_001569556.1 metalloprotein YP_001569557.1 KEGG: sfx:S2588 0. putative PTS system enzyme IIA component, enzyme I K02766:K02768; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001569558.1 KEGG: bat:BAS3585 3.1e-08 Ada regulatory protein/6-O-methylguanine-DNA methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001569559.1 KEGG: stm:STM2402 4.1e-222 yfdZ; putative aminotransferase; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: cytoplasmic, score: 23 YP_001569560.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock YP_001569561.1 COG: NOG13898 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569562.1 Psort location: mitochondrial, score: 23 YP_001569563.1 KEGG: dre:30298 1.7e-05 jak2b; Janus kinase 2b K04447; COG: COG2271 Sugar phosphate permease; Psort location: plasma membrane, score: 23 YP_001569564.1 COG: COG1840 ABC-type Fe3+ transport system, periplasmic component; Psort location: mitochondrial, score: 23 YP_001569565.2 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_001569566.1 Psort location: cytoplasmic, score: 23 YP_001569567.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001569568.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569569.1 COG: COG0730 Predicted permeases; Psort location: cytoplasmic, score: 23 YP_001569570.1 KEGG: sth:STH3153 0.00026 cytochrome C oxidase heme b and copper-binding subunit K00404; COG: COG0730 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001569571.1 KEGG: bur:Bcep18194_C7499 2.4e-91 acyl-CoA dehydrogenase K00253; COG: COG1960 Acyl-CoA dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001569572.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569573.1 KEGG: fra:Francci3_3275 7.1e-16 L-lysine 6-monooxygenase (NADPH) K03897; COG: COG3486 Lysine/orniTHIne N-monooxygenase; Psort location: cytoplasmic, score: 23 YP_001569574.1 KEGG: psp:PSPPH_4690 8.2e-10 formate transporter K00122; COG: COG2116 Formate/nitrite family of transporters; Psort location: plasma membrane, score: 23 YP_001569575.1 COG: COG2853 Surface lipoprotein; Psort location: cytoplasmic, score: 23 YP_001569576.1 COG: COG2067 Long-chain fatty acid transport protein; Psort location: extracellular, including cell wall, score: 9 YP_001569577.1 COG: COG3691 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569578.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_001569579.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_001569580.1 KEGG: sty:STY2619 1.7e-81 phosphohistidine phosphatase K08296; COG: COG2062 Phosphohistidine phosphatase SixA; Psort location: cytoplasmic, score: 23 YP_001569581.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569582.1 Psort location: cytoplasmic, score: 23 YP_001569583.1 involved in methylation of ribosomal protein L3 YP_001569584.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001569585.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001569586.1 COG: COG0730 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001569587.1 COG: COG3101 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569588.1 COG: NOG13546 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569589.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001569590.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001569591.1 COG: NOG26784 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569592.1 COG: NOG18512 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569593.1 COG: COG3423 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001569594.1 COG: NOG28278 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569595.1 KEGG: bja:bll2324 0.00030 long-chain-fatty-acid--[acyl-carrier-protein] ligase / acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001569596.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_001569597.1 KEGG: sec:SC2372 3.5e-193 pdxB; erythronate-4-phosphate dehyrogenase K03473; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001569598.1 KEGG: eci:UTI89_C2604 1.6e-158 usg; USG-1 protein K00133; COG: COG0136 Aspartate-semialdehyde dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001569599.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001569600.1 KEGG: lsl:LSL_1322 1.6e-14 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001569601.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001569602.1 KEGG: sty:STY2596 6.2e-219 folC; folylpolyglutamate synthase K01927:K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: cytoplasmic, score: 23 YP_001569603.1 KEGG: pfo:Pfl_1900 4.3e-12 argininosuccinate synthase K03749; COG: COG3147 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001569604.1 membrane protein required for colicin V production YP_001569605.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001569606.1 KEGG: eci:UTI89_C2502 3.4e-60 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001569607.1 KEGG: stt:t0504 7.3e-255 putative amino acid decarboxylase K01586; COG: COG0019 Diaminopimelate decarboxylase; Psort location: cytoplasmic, score: 23 YP_001569608.1 KEGG: eci:UTI89_C0120 1.3e-05 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001569609.1 KEGG: bce:BC2063 4.0e-05 alanine racemase K01775; COG: COG3457 Predicted amino acid racemase; Psort location: cytoplasmic, score: 23 YP_001569610.1 KEGG: eci:UTI89_C0120 2.6e-53 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0833 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001569611.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_001569612.1 KEGG: bur:Bcep18194_A4695 3.4e-28 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001569613.1 KEGG: bur:Bcep18194_A4695 6.8e-30 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001569614.1 KEGG: sma:SAV6546 1.6e-23 putative ABC transporter permease K02028; COG: COG4215 ABC-type arginine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569615.1 KEGG: sma:SAV6546 6.5e-25 putative ABC transporter permease K02028; COG: COG4160 ABC-type arginine/histidine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569616.1 KEGG: stm:STM2351 1.0e-131 hisP; ABC superfamily (atp_bind), histidine and lysine/arginine/orniTHIne transport protein K02028; COG: COG4598 ABC-type histidine transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001569617.1 KEGG: ava:Ava_0206 9.2e-58 hypothetical protein; COG: COG1090 Predicted nucleoside-diphosphate sugar epimerase; Psort location: cytoplasmic, score: 23 YP_001569618.1 KEGG: eci:UTI89_C2586 4.3e-92 yfcG; putative S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001569619.1 KEGG: eci:UTI89_C2585 6.3e-91 yfcF; hypothetical protein K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001569620.1 KEGG: eci:UTI89_C2584 9.4e-81 yfcE; hypothetical protein; COG: COG0622 Predicted phosphoesterase; Psort location: cytoplasmic, score: 23 YP_001569621.1 KEGG: ssn:SSO_2356 4.7e-86 putative regulator; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001569622.1 KEGG: efa:EF1922 1.4e-06 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001569623.1 Psort location: nuclear, score: 23 YP_001569624.1 KEGG: spt:SPA0520 1.9e-73 putative sugar phosphotransferase component II A K02821; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001569625.1 KEGG: spt:SPA0521 1.9e-41 putative sugar phosphotransferase component II B K02822; COG: COG3414 Phosphotransferase system, galactitol-specific IIB component; Psort location: cytoplasmic, score: 23 YP_001569626.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001569627.1 KEGG: stm:STM2341 3.0e-146 putative transketolase K00615; COG: COG3959 Transketolase, N-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001569628.1 KEGG: stm:STM2340 2.7e-161 putative transketolase K00615; COG: COG3958 Transketolase, C-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001569629.1 COG: COG1288 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001569630.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001569631.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001569632.1 COG: COG3092 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569633.1 COG: COG3013 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001569634.1 KEGG: eci:UTI89_C2575 8.4e-96 yfbT; protein YfbT K01112; COG: COG0637 Predicted phosphatase/phosphohexomutase; Psort location: cytoplasmic, score: 23 YP_001569635.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001569636.1 KEGG: stm:STM2332 3.4e-99 putative hydrolase of HD superfamily K08722; COG: COG1896 Predicted hydrolases of HD superfamily; Psort location: mitochondrial, score: 23 YP_001569637.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001569638.1 KEGG: shn:Shewana3_3435 5.5e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569639.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569640.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001569641.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_001569642.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569643.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001569644.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569645.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569646.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569647.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569648.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569649.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001569650.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569651.1 Catalyzes the transfer of electrons from NADH to quinone YP_001569652.1 KEGG: stm:STM2314 3.8e-164 putative chemotaxis signal transduction protein K03415; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001569653.1 KEGG: stt:t0550 1.8e-116 ribonuclease Z K00784; COG: COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III; Psort location: cytoplasmic, score: 23 YP_001569654.1 Psort location: mitochondrial, score: 23 YP_001569655.1 KEGG: vfi:VF0317 4.3e-28 acetyltransferase K02348; COG: COG2153 Predicted acyltransferase; Psort location: cytoplasmic, score: 23 YP_001569656.1 KEGG: pca:Pcar_1199 0.00073 MCP methyltransferase, CheR-type K00575; COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001569657.1 KEGG: sec:SC2310 5.9e-230 menF; isochorismate synthase (isochorismate hydroxymutase 2), menaquinone biosynthesis K02552; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001569658.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001569659.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_001569660.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001569661.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001569662.1 KEGG: stm:STM2305 1.0e-234 menE; O-succinylbenzoic acid--CoA ligase K01911; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: endoplasmic reticulum, score: 23 YP_001569663.1 COG: NOG11335 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569664.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001569665.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: cytoplasmic, score: 23 YP_001569666.1 Psort location: mitochondrial, score: 23 YP_001569667.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_001569668.1 KEGG: eci:UTI89_C2535 2.5e-87 yfbE; putative glutamine-scyllo-inositol transaminase K07806; COG: COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001569669.1 COG: NOG08101 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569670.1 KEGG: ecc:c2793 3.7e-54 yfaO; putative NUDIX hydrolase YfaO; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001569671.1 COG: NOG08732 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569672.1 KEGG: mmu:319945 2.9e-05 Flad1; RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) K00953; COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: cytoplasmic, score: 23 YP_001569673.1 similar to ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system YP_001569674.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_001569675.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_001569676.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_001569677.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_001569678.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_001569679.1 KEGG: shn:Shewana3_3435 3.0e-20 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569680.1 KEGG: shn:Shewana3_1692 2.4e-07 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001569681.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_001569682.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_001569683.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001569684.1 Involved in ubiquinone biosynthesis YP_001569685.1 negatively supercoils closed circular double-stranded DNA YP_001569686.1 KEGG: sec:SC2274 0. rcsC; sensory histidine kinase in two-component regulatory system with RcsB, regulates colanic capsule biosynthesis K07677; COG: COG0784 FOG: CheY-like receiver; Psort location: endoplasmic reticulum, score: 9 YP_001569687.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_001569688.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_001569689.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_001569690.1 KEGG: spt:SPA0599 1.1e-180 ada; ADA regulatory protein K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001569691.1 COG: COG3145 Alkylated DNA repair protein; Psort location: cytoplasmic, score: 23 YP_001569692.1 efflux pump for the antibacterial peptide microcin J25 YP_001569693.1 KEGG: hpa:HPAG1_0231 8.7e-62 putative sulfate permease K01672; COG: COG0659 Sulfate permease and related transporters (MFS superfamily); Psort location: plasma membrane, score: 23 YP_001569694.1 serine protease inhibitor, inhibits trypsin and other proteases YP_001569695.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA. YP_001569696.1 KEGG: eci:UTI89_C2485 5.2e-32 napD; NapD protein, subunit of nitrate reductase, periplasmic K02570; COG: COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase; Psort location: cytoplasmic, score: 23 YP_001569697.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_001569698.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_001569699.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_001569700.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA YP_001569701.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone YP_001569702.1 ATP-binding protein; required for proper cytochrome c maturation YP_001569703.1 COG: COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569704.1 KEGG: vfi:VF1822 1.3e-81 heme chaperone heme-lyase K02195; COG: COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569705.1 COG: COG3114 Heme exporter protein D; Psort location: cytoplasmic, score: 23 YP_001569706.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001569707.1 KEGG: vfi:VF1819 7.1e-218 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: plasma membrane, score: 23 YP_001569708.1 KEGG: azo:azo3929 9.7e-31 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001569709.1 KEGG: stm:STM4281 1.1e-17 nrfE; putative methylase K04016; COG: COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; Psort location: endoplasmic reticulum, score: 9 YP_001569710.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_001569711.1 Psort location: golgi, score: 9 YP_001569712.1 KEGG: cbu:CBU_1031 3.2e-09 lysozyme, putative K01185; COG: NOG21649 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569713.1 Psort location: endoplasmic reticulum, score: 9 YP_001569714.1 Psort location: cytoplasmic, score: 23 YP_001569715.1 COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001569716.1 Psort location: nuclear, score: 23 YP_001569717.1 COG: COG3209 Rhs family protein; Psort location: nuclear, score: 23 YP_001569718.1 COG: COG3209 Rhs family protein; Psort location: nuclear, score: 23 YP_001569719.1 COG: COG3209 Rhs family protein; Psort location: nuclear, score: 23 YP_001569720.1 COG: NOG06259 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569721.1 COG: NOG25827 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569722.1 COG: NOG27507 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569723.1 COG: COG0583 Transcriptional regulator; Psort location: vesicles of secretory system, score: 9 YP_001569724.1 KEGG: aha:AHA_1664 9.5e-104 putative sulfatase; COG: COG3083 Predicted hydrolase of alkaline phosphatase superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001569725.1 COG: COG3082 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001569726.1 Psort location: nuclear, score: 23 YP_001569727.1 COG: COG3081 Nucleoid-associated protein; Psort location: cytoplasmic, score: 23 YP_001569728.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001569729.1 KEGG: eci:UTI89_C2461 0. yejH; hypothetical protein YejH K01529; COG: COG1061 DNA or RNA helicases of superfamily II; Psort location: cytoplasmic, score: 23 YP_001569730.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_001569731.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_001569732.1 COG: NOG14216 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001569733.1 KEGG: pen:PSEEN3568 8.2e-153 ABC transporter, ATP-binding protein; COG: COG4172 ABC-type uncharacterized transport system, duplicated ATPase component; Psort location: cytoplasmic, score: 23 YP_001569734.1 KEGG: syf:Synpcc7942_2454 4.3e-05 adenine phosphoribosyltransferase K00759; COG: COG4239 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569735.1 KEGG: syf:Synpcc7942_2454 1.5e-32 adenine phosphoribosyltransferase K00759; COG: COG4174 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569736.1 COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001569737.1 KEGG: vfi:VF0494 3.4e-33 sensory transduction protein kinase; COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001569738.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_001569739.1 KEGG: eci:UTI89_C2451 7.6e-102 hypothetical protein K01094; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001569740.1 KEGG: reh:H16_A3373 3.2e-16 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001569741.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_001569742.1 COG: NOG23005 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569743.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001569744.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_001569745.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_001569746.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001569747.1 activator of nucleoside metabolism YP_001569748.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively YP_001569749.1 COG: COG1972 Nucleoside permease; Psort location: plasma membrane, score: 23 YP_001569750.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001569751.1 Psort location: nuclear, score: 23 YP_001569752.1 COG: COG2855 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001569753.1 KEGG: shn:Shewana3_3435 1.7e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569754.1 KEGG: eci:UTI89_C0120 9.8e-70 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0833 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001569755.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein YP_001569756.1 COG: COG2271 Sugar phosphate permease; Psort location: plasma membrane, score: 23 YP_001569757.1 KEGG: aba:Acid345_2803 3.8e-45 phosphoserine phosphatase SerB K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: cytoplasmic, score: 23 YP_001569758.1 Psort location: cytoplasmic, score: 23 YP_001569759.1 Psort location: cytoplasmic, score: 23 YP_001569760.1 KEGG: sec:SC2212 1.3e-227 sdhL; putative D-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: mitochondrial, score: 23 YP_001569761.1 COG: COG1396 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001569762.1 KEGG: spt:SPA0657 2.5e-158 yeiG; putative esterase K03929; COG: COG0627 Predicted esterase; Psort location: cytoplasmic, score: 23 YP_001569763.1 Psort location: cytoplasmic, score: 23 YP_001569764.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001569765.1 COG: COG2311 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001569766.1 negative regulator of the mglBAC operon for galactose utilization YP_001569767.1 KEGG: msm:MSMEG_3095 5.6e-13 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001569768.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_001569769.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_001569770.1 KEGG: eco:b2147 8.0e-19 yeiA, yeiA'; dihydropyrimidine dehydrogenase; COG: COG1146 Ferredoxin; Psort location: endoplasmic reticulum, score: 9 YP_001569771.1 KEGG: nwi:Nwi_1143 0.00014 helix-turn-helix, fis-type K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569772.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001569773.1 COG: COG5302 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid; Psort location: cytoplasmic, score: 23 YP_001569774.1 COG: NOG11316 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569775.1 Psort location: cytoplasmic, score: 23 YP_001569776.1 COG: NOG10019 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569777.1 Psort location: nuclear, score: 23 YP_001569778.1 COG: NOG13896 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569779.1 COG: COG2949 Uncharacterized membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001569780.1 COG: COG3335 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569781.1 KEGG: cab:CAB679 0.0083 asd; aspartate-semialdehyde dehydrogenase K00133; Psort location: mitochondrial, score: 23 YP_001569782.1 Psort location: cytoplasmic, score: 23 YP_001569783.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001569784.1 KEGG: bcz:BCZK3376 8.7e-30 murein hydrolase export regulator K01238; COG: COG1346 Putative effector of murein hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001569785.1 KEGG: btk:BT9727_3424 1.9e-11 murein hydrolase exporter K06518; COG: COG1380 Putative effector of murein hydrolase LrgA; Psort location: endoplasmic reticulum, score: 9 YP_001569786.1 KEGG: shn:Shewana3_3435 2.6e-10 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569787.1 KEGG: cal:orf19.6005 1.8e-05 STL13; sugar transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001569788.1 Psort location: cytoplasmic, score: 23 YP_001569789.1 KEGG: sec:SC2191 4.5e-145 yohI; putative nitrogen regulation protein K05541; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001569790.1 COG: NOG33037 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569791.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_001569792.1 KEGG: stm:STM2171 7.1e-131 yohF; oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001569793.1 KEGG: oih:OB2407 0.0015 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001569794.1 COG: NOG06773 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569795.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_001569796.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001569797.1 Psort location: cytoplasmic, score: 23 YP_001569798.1 KEGG: stm:STM2166 0. bglX; beta-D-glucoside glucohydrolase, periplasmic K05349; COG: COG1472 Beta-glucosidase-related glycosidases; Psort location: extracellular, including cell wall, score: 9 YP_001569799.1 KEGG: lwe:lwe1439 5.1e-25 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001569800.1 KEGG: lwe:lwe1439 1.2e-34 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001569801.1 KEGG: bur:Bcep18194_B0497 1.0e-67 ABC proline/glycine betaine transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001569802.1 KEGG: lwe:lwe1439 2.4e-34 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001569803.1 KEGG: eci:UTI89_C3737 3.0e-07 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001569804.1 KEGG: stm:STM2159 1.4e-290 yehU; paral putative sensor/kinase in regulatory system K07704; COG: COG3275 Putative regulator of cell autolysis; Psort location: plasma membrane, score: 23 YP_001569805.1 unknown function; when overproduced it confers drug-resistance YP_001569806.1 COG: COG4807 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001569807.1 Psort location: endoplasmic reticulum, score: 9 YP_001569808.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001569809.1 KEGG: eci:UTI89_C2387 1.1e-191 mrp; putative ATPase K03593; COG: COG0489 ATPases involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001569810.1 COG: NOG18135 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569811.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001569812.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001569813.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001569814.1 COG: NOG07909 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001569815.1 COG: COG5455 Predicted integral membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001569816.1 Psort location: nuclear, score: 23 YP_001569817.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001569818.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001569819.1 KEGG: reh:H16_B1289 3.0e-12 phnF; regulator of phosphonate operon, GntR-family; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001569820.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_001569821.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_001569822.1 COG: NOG24672 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569823.1 KEGG: stm:STM2136 6.5e-247 yegQ; putative protease K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001569824.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_001569825.1 KEGG: sec:SC2132 1.6e-245 baeS, baeR; sensory kinase in two-component regulatoyr system wtih BaeR K07642; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001569826.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001569827.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_001569828.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001569829.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001569830.1 KEGG: mbo:Mb0358 2.9e-07 dnaK; probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kda protein) (HSP70) K04043; COG: COG0443 Molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001569831.1 Psort location: nuclear, score: 23 YP_001569832.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_001569833.1 KEGG: eci:UTI89_C2343 0. yegE; putative sensor-type protein; COG: COG2199 FOG: GGDEF domain; Psort location: plasma membrane, score: 23 YP_001569834.1 Psort location: cytoplasmic, score: 23 YP_001569835.1 Psort location: cytoplasmic, score: 23 YP_001569836.1 KEGG: sty:STY2335 9.6e-79 udk; uridine kinase K00876; COG: COG0572 Uridine kinase; Psort location: cytoplasmic, score: 23 YP_001569837.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001569838.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_001569839.1 Psort location: nuclear, score: 23 YP_001569840.1 KEGG: eci:UTI89_C0656 3.6e-24 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: plasma membrane, score: 23 YP_001569841.1 Psort location: nuclear, score: 23 YP_001569842.1 COG: COG1596 Periplasmic protein involved in polysaccharide export; Psort location: extracellular, including cell wall, score: 9 YP_001569843.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_001569844.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_001569845.1 KEGG: eci:UTI89_C2333 5.4e-140 wcaA; putative colanic acid biosynthesis glycosyltransferase WcaA; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001569846.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_001569847.1 KEGG: eci:UTI89_C2331 8.9e-179 wcaC; putative glycosyltransferase K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001569848.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_001569849.1 KEGG: eci:UTI89_C2329 6.8e-94 wcaE; putative colanic acid biosynthesis glycosyl transferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001569850.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_001569851.1 KEGG: stm:STM2109 6.6e-199 gmd; GDP-D-mannose dehydratase K01711; COG: COG1089 GDP-D-mannose dehydratase; Psort location: cytoplasmic, score: 23 YP_001569852.1 KEGG: stm:STM2108 8.2e-169 wcaG; bifunctional GDP fucose synthetase in colanic acid biosyntheis K02377; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001569853.1 KEGG: sec:SC2108 5.9e-79 wcaI; putative glycosyl transferase in colanic acid biosynthesis K03207; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001569854.1 KEGG: eci:UTI89_C2324 1.2e-188 wcaI; putative colanic biosynthesis glycosyl transferase K03208; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001569855.1 KEGG: sec:SC2106 2.9e-260 manC; mannose-1-phosphate in colanic acid gene cluster K00971; COG: COG0662 Mannose-6-phosphate isomerase; Psort location: cytoplasmic, score: 23 YP_001569856.1 KEGG: stm:STM2104 1.3e-227 cpsG; phosphomannomutase in colanic acid gene cluster K01840; COG: COG1109 Phosphomannomutase; Psort location: cytoplasmic, score: 23 YP_001569857.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001569858.1 KEGG: tma:TM0158 0.0040 prolipoprotein diacylglyceryl transferase K00785; COG: NOG22285 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001569859.1 KEGG: chy:CHY_1055 2.4e-06 glycosyl transferase, group 1 family K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001569860.1 KEGG: vfi:VF0191 8.9e-140 UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose 3,5-epimerase K01726; COG: COG1086 Predicted nucleoside-diphosphate sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001569861.1 KEGG: rco:RC0456 8.6e-71 putative dTDP-4-dehydrorhamnose reductase K00067; COG: COG1091 dTDP-4-dehydrorhamnose reductase; Psort location: cytoplasmic, score: 23 YP_001569862.1 KEGG: lic:LIC12139 1.1e-132 rffE; UDP-N-acetylglucosamine 2-epimerase K01791; COG: COG0381 UDP-N-acetylglucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001569863.1 KEGG: bcz:BCZK4973 9.9e-23 wciJ; glycosyl transferase, group 1; possible capsular polysaccharide biosynthesis protein K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001569864.1 KEGG: pub:SAR11_0523 4.5e-10 glucose-6-phosphate isomerase-like protein K01810; COG: NOG13250 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569865.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001569866.1 KEGG: sec:SC2090 1.6e-195 udg; UDP-glucose/GDP-mannose dehydrogenase K00012; COG: COG1004 Predicted UDP-glucose 6-dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001569867.1 KEGG: rsp:RSP_4084 1.3e-06 predicted acetyltransferase K00903; COG: COG3765 Chain length determinant protein; Psort location: endoplasmic reticulum, score: 9 YP_001569868.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001569869.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001569870.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001569871.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001569872.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001569873.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001569874.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001569875.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001569876.1 KEGG: mth:MTH1789 1.2e-07 dTDP-glucose 4,6-dehydratase K01710; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: endoplasmic reticulum, score: 9 YP_001569877.1 Psort location: cytoplasmic, score: 23 YP_001569878.1 KEGG: eci:UTI89_C0120 9.2e-15 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001569879.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001569880.1 COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001569881.1 COG: NOG12779 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569882.1 Psort location: cytoplasmic, score: 23 YP_001569883.1 KEGG: stm:STM2065 0. phsA; Hydrogen sulfide production: membrane anchoring protein K08352; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001569884.1 KEGG: eci:UTI89_C1863 1.1e-52 putative oxidoreductase Fe-S subunit K00178; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001569885.1 KEGG: bbr:BB2124 1.0e-06 fdhC; formate dehydrogenase subunit C precursor K00127; COG: COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein); Psort location: endoplasmic reticulum, score: 9 YP_001569886.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001569887.1 COG: COG3449 DNA gyrase inhibitor; Psort location: cytoplasmic, score: 23 YP_001569888.1 COG: COG1289 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001569889.1 KEGG: pac:PPA1242 0.0036 ATP synthase delta chain K02113; COG: COG2926 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001569890.1 KEGG: lwe:lwe1128 2.0e-48 propanediol utilization kinase PduX K01009; COG: COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase; Psort location: cytoplasmic, score: 23 YP_001569891.1 involved in coenzyme B(12)-dependent 1, 2-propanediol degradation; important for the synthesis of propionyl coenzyme A during growth on 1,2-propanediol YP_001569892.1 KEGG: ctc:CTC01446 7.1e-12 lysine-sensitive aspartokinase III K00928; COG: COG4917 Ethanolamine utilization protein; Psort location: mitochondrial, score: 23 YP_001569893.1 COG: COG4810 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001569894.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001569895.1 KEGG: eci:UTI89_C1819 1.1e-39 rnfC; electron transport complex protein RnfC K03615; COG: COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC; Psort location: cytoplasmic, score: 23 YP_001569896.1 KEGG: sec:SC2060 1.1e-157 pduQ; propanediol utilization: propanol dehydrogenase K00100; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: mitochondrial, score: 23 YP_001569897.1 KEGG: rru:Rru_A0914 7.3e-113 aldehyde dehydrogenase K04021; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001569898.1 KEGG: noc:Noc_0867 1.3e-26 cobalamin adenosyltransferase K00798; COG: COG2096 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001569899.1 KEGG: rru:Rru_A0384 0.0088 NADPH-quinone reductase K00344; COG: COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: mitochondrial, score: 23 YP_001569900.1 COG: NOG15374 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569901.1 KEGG: dar:Daro_2921 2.2e-40 acetate kinase K00925; COG: COG4869 Propanediol utilization protein; Psort location: cytoplasmic, score: 23 YP_001569902.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: extracellular, including cell wall, score: 9 YP_001569903.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001569904.1 COG: NOG12182 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569905.1 COG: NOG06036 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569906.1 KEGG: sec:SC2050 4.8e-77 pduE; propanediol utilization: dehydratase, small subunit K06122; COG: COG4910 Propanediol dehydratase, small subunit; Psort location: nuclear, score: 23 YP_001569907.1 KEGG: stm:STM2041 1.1e-104 pduD; Propanediol utilization: dehydratase, medium subunit K06121; COG: COG4909 Propanediol dehydratase, large subunit; Psort location: cytoplasmic, score: 23 YP_001569908.1 KEGG: stm:STM2040 1.1e-290 pduC; glycerol dehydratase large subunit K06120; COG: COG4909 Propanediol dehydratase, large subunit; Psort location: cytoplasmic, score: 23 YP_001569909.1 KEGG: nfa:nfa52250 0.0031 putative protease; COG: COG4816 Ethanolamine utilization protein; Psort location: endoplasmic reticulum, score: 9 YP_001569910.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001569911.1 KEGG: fal:FRAAL3366 6.9e-05 putative arsenate reductase (partial match); COG: COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Psort location: plasma membrane, score: 23 YP_001569912.1 KEGG: bsu:BG10166 1.4e-12 adaA; methylphosphotriester-DNA alkyltransferase / transcriptional regulator (AraC family) K00567; COG: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; Psort location: nuclear, score: 23 YP_001569913.1 Psort location: nuclear, score: 23 YP_001569914.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001569915.1 CobD; CbiB in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_001569916.1 catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin YP_001569917.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_001569918.1 catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a YP_001569919.1 catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating YP_001569920.1 KEGG: stm:STM2029 8.7e-133 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: cytoplasmic, score: 23 YP_001569921.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_001569922.1 KEGG: sec:SC2035 1.0e-122 cbiH; synthesis of vitamin B12 adenosyl cobalamide precursor K03395; COG: COG1010 Precorrin-3B methylase; Psort location: cytoplasmic, score: 23 YP_001569923.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_001569924.1 KEGG: sec:SC2033 5.0e-137 cbiK; synthesis of vitamin B12 adenosyl cobalamide precursor K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: cytoplasmic, score: 23 YP_001569925.1 catalyzes the formation of precorrin-3A from precorrin-2 YP_001569926.1 catalyzes the ATP-dependent transport of cobalt YP_001569927.1 periplasmic cobalt binding component of the cobalt transport system YP_001569928.1 COG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: endoplasmic reticulum, score: 9 YP_001569929.1 with CbiNQ forms the ABC transporter for cobalt import YP_001569930.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001569931.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_001569932.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_001569933.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_001569934.1 KEGG: eci:UTI89_C2228 1.3e-129 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001569935.1 Psort location: nuclear, score: 23 YP_001569936.1 COG: COG3209 Rhs family protein; Psort location: nuclear, score: 23 YP_001569937.1 COG: COG3328 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569938.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001569939.1 COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001569940.1 Psort location: mitochondrial, score: 23 YP_001569941.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_001569942.1 COG: NOG24950 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569943.1 COG: COG0582 Integrase; Psort location: mitochondrial, score: 23 YP_001569944.1 Psort location: mitochondrial, score: 23 YP_001569945.1 KEGG: lsa:LSA0897 3.9e-66 pepD5; dipeptidase D-type (U34 family) K01274; COG: COG4690 Dipeptidase; Psort location: nuclear, score: 23 YP_001569946.1 Psort location: nuclear, score: 23 YP_001569947.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001569948.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569949.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569950.1 COG: COG1840 ABC-type Fe3+ transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001569951.1 KEGG: cyb:CYB_0398 2.3e-08 modB; molybdate ABC transporter, permease protein K02018; COG: COG1178 ABC-type Fe3+ transport system, permease component; Psort location: plasma membrane, score: 23 YP_001569952.1 KEGG: rru:Rru_A3201 6.4e-66 ABC transporter component K06020; COG: COG3839 ABC-type sugar transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001569953.1 KEGG: hsa:23035 7.7e-08 PHLPPL; PH domain and leucine rich repeat protein phosphatase-like K01090; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001569954.1 Psort location: mitochondrial, score: 23 YP_001569955.1 COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: cytoplasmic, score: 23 YP_001569956.1 KEGG: sgl:SG0100 6.7e-87 putative N-acetylmuramoyl-L-alanine amidase K01446; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: cytoplasmic, score: 23 YP_001569957.1 Psort location: mitochondrial, score: 23 YP_001569958.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001569959.1 COG: COG3228 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001569960.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001569961.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001569962.1 COG: COG3436 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569963.1 COG: COG3436 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569964.1 Psort location: nuclear, score: 23 YP_001569965.1 Psort location: cytoplasmic, score: 23 YP_001569966.1 Psort location: cytoplasmic, score: 23 YP_001569967.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoskeletal, score: 9 YP_001569968.1 Psort location: extracellular, including cell wall, score: 9 YP_001569969.1 Psort location: cytoplasmic, score: 23 YP_001569970.1 Psort location: endoplasmic reticulum, score: 9 YP_001569971.1 Psort location: endoplasmic reticulum, score: 9 YP_001569972.1 Psort location: cytoplasmic, score: 23 YP_001569973.1 Psort location: cytoplasmic, score: 23 YP_001569974.1 Psort location: nuclear, score: 23 YP_001569975.1 COG: NOG29407 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001569976.1 COG: NOG35479 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569977.1 Psort location: cytoplasmic, score: 23 YP_001569978.1 Psort location: cytoplasmic, score: 23 YP_001569979.1 Psort location: cytoplasmic, score: 23 YP_001569980.1 Psort location: cytoplasmic, score: 23 YP_001569981.1 COG: COG3311 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001569982.1 COG: NOG07910 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001569983.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001569984.1 Psort location: cytoplasmic, score: 23 YP_001569985.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001569986.1 KEGG: nwi:Nwi_1018 1.2e-09 helix-turn-helix, fis-type K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569987.1 KEGG: ana:alr3268 1.3e-07 serine/threonine kinase K08884; COG: COG1357 Uncharacterized low-complexity proteins; Psort location: cytoplasmic, score: 23 YP_001569988.1 Psort location: nuclear, score: 23 YP_001569989.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001569990.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001569991.1 Psort location: nuclear, score: 23 YP_001569992.1 COG: COG3203 Outer membrane protein (porin); Psort location: cytoplasmic, score: 23 YP_001569993.1 COG: COG3203 Outer membrane protein (porin); Psort location: cytoplasmic, score: 23 YP_001569994.1 Psort location: cytoplasmic, score: 23 YP_001569995.1 Psort location: cytoplasmic, score: 23 YP_001569996.1 Psort location: cytoplasmic, score: 23 YP_001569997.1 COG: NOG20643 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001569998.1 KEGG: stm:STM1992 8.7e-252 dcm; DNA cytosine methylase K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001569999.1 KEGG: stm:STM1991 1.0e-81 vsr; DNA mismatch endonuclease, patch repair protein K07458; COG: COG3727 DNA G:T-mismatch repair endonuclease; Psort location: cytoplasmic, score: 23 YP_001570000.1 KEGG: syw:SYNW0942 0.0036 putative phosphatidate cytidylyltransferase K00981; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001570001.1 Psort location: nuclear, score: 23 YP_001570002.1 COG: COG2354 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001570003.1 COG: COG5475 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001570004.1 KEGG: vfi:VFA0796 1.3e-24 sensor protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001570005.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_001570006.1 COG: NOG14111 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570007.1 COG: NOG14105 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570008.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001570009.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001570010.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001570011.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001570012.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus YP_001570013.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001570014.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_001570015.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_001570016.1 KEGG: sce:YIR019C 0.0047 MUC1; Required for invasion and pseudohyphae formation in response to nitrogen starvation K01178; COG: COG3144 Flagellar hook-length control protein; Psort location: nuclear, score: 23 YP_001570017.1 rod/hook and filament chaperone YP_001570018.1 involved in type III protein export during flagellum assembly YP_001570019.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001570020.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001570021.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001570022.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_001570023.1 COG: NOG29680 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570024.1 COG: COG0425 Predicted redox protein, regulator of disulfide bond formation; Psort location: nuclear, score: 23 YP_001570025.1 COG: COG2391 Predicted transporter component; Psort location: endoplasmic reticulum, score: 9 YP_001570026.1 COG: NOG09020 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570027.1 KEGG: spt:SPA0907 5.3e-62 amyA; cytoplasmic alpha-amylase K01176; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001570028.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_001570029.1 flagellin specific chaperone YP_001570030.1 involved in flagellin assembly YP_001570031.1 Psort location: nuclear, score: 23 YP_001570032.1 COG: COG1344 Flagellin and related hook-associated proteins; Psort location: nuclear, score: 23 YP_001570033.1 KEGG: sec:SC1961 3.4e-179 fliB; N-methylation of lysine residues in flagellin K00599; COG: NOG18602 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570034.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_001570035.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence YP_001570036.1 KEGG: eci:UTI89_C2121 1.1e-127 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001570037.1 catalyzes the formation of pyruvate from D-cysteine YP_001570038.1 KEGG: hpa:HPAG1_0922 1.7e-40 amino acid ABC transporter, permease protein; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001570039.1 KEGG: spt:SPA0918 2.2e-120 yecC; putative ABC transport ATP-binding protein K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001570040.1 regulates genes involved in cell division YP_001570041.1 COG: NOG13894 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570042.1 COG: NOG33125 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570043.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_001570044.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001570045.1 KEGG: stt:t0931 4.6e-95 pgsA; phosphotidylglycerophosphate synthetase K00995; COG: COG0558 Phosphatidylglycerophosphate synthase; Psort location: endoplasmic reticulum, score: 9 YP_001570047.1 COG: NOG33408 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001570048.1 Psort location: cytoplasmic, score: 23 YP_001570049.1 KEGG: rba:RB11119 0.0028 pipeptidyl-peptidase VI; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001570050.1 COG: NOG33353 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570051.1 COG: COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA; Psort location: cytoplasmic, score: 23 YP_001570052.1 KEGG: lpl:lp_3010 0.0065 pts23C; cellobiose PTS, EIIC K02761; COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001570053.1 COG: NOG14112 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570054.1 cytoplasmic iron storage protein YP_001570055.1 COG: NOG11332 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570056.1 Psort location: extracellular, including cell wall, score: 9 YP_001570057.1 KEGG: stm:STM1933 1.6e-108 hypothetical protein K01806; COG: COG0698 Ribose 5-phosphate isomerase RpiB; Psort location: cytoplasmic, score: 23 YP_001570058.1 COG: NOG15359 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570059.1 KEGG: cel:D1037.3 0.0047 ferritin; D1037.3 K00522; COG: COG1528 Ferritin-like protein; Psort location: cytoplasmic, score: 23 YP_001570060.1 KEGG: ppu:PP_2725 1.2e-14 pfpI; protease PfpI K05520; COG: COG0693 Putative intracellular protease/amidase; Psort location: extracellular, including cell wall, score: 23 YP_001570061.1 KEGG: eco:b4460 1.0e-35 araH; fused L-arabinose transporter subunits of ABC superfamily: membrane components K02057; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001570062.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_001570063.1 KEGG: stt:t0949 3.9e-256 otsA; trehalose-6-phosphate synthase K00697; COG: COG0380 Trehalose-6-phosphate synthase; Psort location: cytoplasmic, score: 23 YP_001570064.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001570065.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_001570066.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_001570067.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001570068.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001570069.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_001570070.1 KEGG: eci:UTI89_C2090 1.9e-75 cheW; CheW positive regulator of CheA protein activity K03408; COG: COG0835 Chemotaxis signal transduction protein; Psort location: cytoplasmic, score: 23 YP_001570071.1 Psort location: mitochondrial, score: 23 YP_001570072.1 KEGG: chu:CHU_0838 0.0041 CHU large protein; uncharacterized K01238; COG: COG5430 Uncharacterized secreted protein; Psort location: extracellular, including cell wall, score: 9 YP_001570073.1 COG: COG5430 Uncharacterized secreted protein; Psort location: cytoplasmic, score: 23 YP_001570074.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001570075.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001570076.1 COG: COG5430 Uncharacterized secreted protein; Psort location: extracellular, including cell wall, score: 9 YP_001570077.1 KEGG: vpa:VPA0675 6.8e-12 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001570078.1 methylates the MCP YP_001570079.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001570080.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_001570081.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_001570082.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001570083.1 membrane protein involved in the flagellar export apparatus YP_001570084.1 COG: NOG12148 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570085.1 Psort location: nuclear, score: 23 YP_001570086.1 KEGG: eci:UTI89_C4210 6.6e-17 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001570087.1 COG: COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins; Psort location: cytoplasmic, score: 23 YP_001570088.1 KEGG: eci:UTI89_C0637 4.9e-194 mrdA; cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 K05515; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: cytoplasmic, score: 23 YP_001570089.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001570090.1 COG: COG3102 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570091.1 COG: COG3142 Uncharacterized protein involved in copper resistance; Psort location: cytoplasmic, score: 23 YP_001570092.1 KEGG: eci:UTI89_C2075 3.3e-165 yecP; hypothetical protein K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001570093.1 KEGG: eci:UTI89_C2074 8.0e-123 yecO; hypothetical protein K00559; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001570094.1 KEGG: hsa:4056 3.4e-05 LTC4S; leukotriene C4 synthase K00807; COG: COG3788 Uncharacterized relative of glutaTHIone S-transferase, MAPEG superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001570095.1 COG: COG1801 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570096.1 KEGG: eci:UTI89_C2071 5.3e-78 yecD; hypothetical protein; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001570097.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001570098.1 converts dATP to dAMP and pyrophosphate YP_001570099.1 KEGG: eci:UTI89_C2068 2.2e-127 yebC; hypothetical protein K00975; COG: COG0217 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570100.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001570101.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001570102.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001570103.1 involved in transport of zinc(II) with ZnuA and C YP_001570104.1 involved in transport of zinc(II) with ZnuA and C YP_001570105.1 involved in transport of zinc(II) with ZnuA and C YP_001570106.1 KEGG: spt:SPA0979 3.7e-221 yebA; hypothetical protein; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: cytoplasmic, score: 23 YP_001570107.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_001570108.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001570109.1 Represses the expression of the zwf, eda, glp and gap YP_001570110.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001570111.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001570112.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001570113.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001570114.1 COG: COG3141 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570115.1 secreted protein; unknown function YP_001570116.1 COG: COG2979 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570117.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_001570118.1 3'-5' exonuclease activity on single or double-strand DNA YP_001570119.1 KEGG: psp:PSPPH_2956 0.00086 hydrolase, carbon-nitrogen family K01950; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001570120.1 KEGG: spt:SPA0993 4.0e-34 holE; DNA polymerase III, theta subunit K02345; COG: NOG13893 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570121.1 COG: COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC; Psort location: extracellular, including cell wall, score: 9 YP_001570122.1 COG: COG1276 Putative copper export protein; Psort location: plasma membrane, score: 23 YP_001570123.1 COG: NOG09766 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570124.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001570125.1 Psort location: cytoplasmic, score: 23 YP_001570126.1 Psort location: cytoplasmic, score: 23 YP_001570127.1 Psort location: cytoplasmic, score: 23 YP_001570128.1 KEGG: rno:59265 6.8e-09 Phlpp; PH domain and leucine rich repeat protein phosphatase K01090; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001570129.1 Psort location: cytoplasmic, score: 23 YP_001570130.1 Psort location: cytoplasmic, score: 23 YP_001570131.1 COG: NOG25496 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570132.1 Psort location: mitochondrial, score: 23 YP_001570133.1 COG: NOG23759 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570134.1 COG: NOG18552 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570135.1 Psort location: cytoplasmic, score: 23 YP_001570136.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_001570137.1 COG: NOG12164 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570138.1 COG: NOG13883 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570139.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_001570140.1 COG: COG3008 Paraquat-inducible protein B; Psort location: endoplasmic reticulum, score: 9 YP_001570141.1 COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: endoplasmic reticulum, score: 9 YP_001570142.1 KEGG: gbe:GbCGDNIH1_0602 0.0028 phosphoenolpyruvate-protein phosphotransferase; COG: COG1956 GAF domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001570143.1 affects solute and DNA transport through an unknown mechanism YP_001570144.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_001570145.1 putative metalloprotease YP_001570146.1 KEGG: sgl:SG1466 4.6e-07 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001570147.1 COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570148.1 COG: NOG13884 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570149.1 COG: NOG18120 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570150.1 COG: NOG11327 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570151.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001570152.1 KEGG: eca:ECA3821 1.4e-198 ftsI, pbpB; peptidoglycan synthetase K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: endoplasmic reticulum, score: 9 YP_001570153.1 KEGG: spt:SPA1038 5.2e-119 rrmA; rRNA guanine-N1-methyltransferase K00563; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001570154.1 membrane protein YebN YP_001570155.1 COG: COG4811 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001570156.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_001570157.1 KEGG: eci:UTI89_C2015 2.8e-127 manY; PTS enzyme IIC, mannose-specific K02795; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001570158.1 KEGG: spt:SPA1043 7.0e-163 manX; PTS system, mannose-specific IIAB component K02793:K02794; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001570159.1 KEGG: eci:UTI89_C0656 3.5e-25 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: plasma membrane, score: 23 YP_001570160.1 KEGG: eci:UTI89_C1702 7.6e-30 hypothetical protein; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 23 YP_001570161.1 KEGG: stt:t1051 3.0e-242 sdaA; L-serine deaminase 1 K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001570162.1 KEGG: gbe:GbCGDNIH1_1634 1.6e-30 coA pyrophosphatase K01529; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001570163.1 KEGG: stm:STM1824 2.8e-239 pabB; p-aminobenzoate synthetase, component I K01665; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: extracellular, including cell wall, score: 9 YP_001570164.1 COG: COG3140 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001570165.1 KEGG: mxa:MXAN_0920 1.3e-05 2-aminomuconate deaminase; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001570166.1 KEGG: sty:STY1951 0. putative ATP-dependent helicase K03722; COG: COG1199 Rad3-related DNA helicases; Psort location: cytoplasmic, score: 23 YP_001570167.1 KEGG: ecc:c2211 7.6e-102 yeaZ; hypothetical protease YeaZ K01423; COG: COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001570168.1 COG: COG3065 Starvation-inducible outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001570169.1 KEGG: sec:SC1810 2.9e-196 rnd; RNase D, processes tRNA precursor K03684; COG: COG0349 Ribonuclease D; Psort location: cytoplasmic, score: 23 YP_001570170.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_001570171.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_001570172.1 blocks the formation of polar Z-ring septums YP_001570173.1 COG: COG3100 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001570174.1 KEGG: bpm:BURPS1710b_A0012 1.1e-38 fumarylacetoacetate (FAA) hydrolase K01557; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001570175.1 COG: COG2983 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570176.1 COG: NOG32497 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570177.1 COG: NOG18116 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570178.1 COG: COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance; Psort location: mitochondrial, score: 23 YP_001570179.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_001570180.1 involved in regulation of intracellular pH under alkaline conditions YP_001570181.1 Multifunctional regulator of fatty acid metabolism YP_001570182.1 COG: COG2719 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570183.1 catalyzes the oxidative deamination of D-amino acids YP_001570184.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_001570185.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001570186.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_001570187.1 KEGG: stm:STM1799 1.1e-86 emtA; membrane-bound lytic murein transglycosylase E K08308; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: cytoplasmic, score: 23 YP_001570188.1 COG: COG5581 Predicted glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001570189.1 KEGG: cjk:jk1171 0.00073 cdsA; phosphatidate cytidylyltransferase K00981; COG: COG2261 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001570190.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_001570191.1 KEGG: stm:STM1795 3.8e-235 putative glutamic dehyrogenase-like protein K00261; COG: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001570192.1 KEGG: sty:STY1921 2.8e-198 appB; probable cytochrome oxidase subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001570193.1 KEGG: stm:STM1792 2.3e-274 putative cytochrome oxidase, subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: endoplasmic reticulum, score: 9 YP_001570194.1 KEGG: eci:UTI89_C1045 6.6e-112 hyaF; hydrogenase-1 operon protein HyaF K03618; COG: NOG06279 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570195.1 involved in processing hydrogenase proteins HyaA and HyaB YP_001570196.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1) YP_001570197.1 KEGG: eci:UTI89_C1042 5.3e-110 hyaC; probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit K03620; COG: COG1969 Ni,Fe-hydrogenase I cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001570198.1 involved in hydrogen cycling during fermentative growth YP_001570199.1 KEGG: stm:STM1786 1.1e-205 hydrogenase small chain K06282; COG: COG1740 Ni,Fe-hydrogenase I small subunit; Psort location: cytoplasmic, score: 23 YP_001570200.1 Psort location: cytoplasmic, score: 23 YP_001570201.1 Psort location: cytoplasmic, score: 23 YP_001570202.1 KEGG: yps:YPTB3074 3.1e-256 putative sulfatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001570203.1 Psort location: cytoplasmic, score: 23 YP_001570204.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001570205.1 KEGG: ype:YPO0834 1.1e-77 manX; PTS system, N-acetylgalactosamine-specific II component K02745; COG: COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001570206.1 KEGG: eci:UTI89_C3570 8.6e-39 agaC; PTS system, N-acetylgalactosamine-specific IIC component 1 K02746; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: plasma membrane, score: 23 YP_001570207.1 KEGG: eci:UTI89_C3571 3.4e-44 agaD; PTS system, N-acetylgalactosamine-specific IID component K02747; COG: COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; Psort location: plasma membrane, score: 23 YP_001570208.1 KEGG: ypk:y3222 1.7e-56 N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component K02744; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001570209.1 Psort location: cytoplasmic, score: 23 YP_001570210.1 COG: COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins; Psort location: mitochondrial, score: 23 YP_001570211.1 Psort location: mitochondrial, score: 23 YP_001570212.1 KEGG: syg:sync_2368 1.1e-13 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001570213.1 KEGG: ypn:YPN_3044 6.1e-251 sulfatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: extracellular, including cell wall, score: 9 YP_001570214.1 COG: COG4289 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570215.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001570216.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001570217.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_001570218.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_001570219.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001570220.1 Psort location: nuclear, score: 23 YP_001570221.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001570222.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001570223.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001570224.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001570225.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_001570226.1 COG: COG3094 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001570227.1 COG: COG2912 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570228.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001570229.1 COG: COG0387 Ca2+/H+ antiporter; Psort location: plasma membrane, score: 23 YP_001570230.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_001570231.1 COG: COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction; Psort location: cytoplasmic, score: 23 YP_001570232.1 COG: NOG06760 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570233.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_001570234.1 KEGG: stm:STM1766 0. narX; two-component system, NarL family, sensor kinase K07673; COG: COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; Psort location: endoplasmic reticulum, score: 9 YP_001570235.1 COG: COG2223 Nitrate/nitrite transporter; Psort location: endoplasmic reticulum, score: 9 YP_001570236.1 Psort location: cytoplasmic, score: 23 YP_001570237.1 KEGG: stm:STM1764 0. narG; nitrate reductase alpha chain K00370; COG: COG5013 Nitrate reductase alpha subunit; Psort location: cytoplasmic, score: 23 YP_001570238.1 KEGG: stt:t1672 9.3e-287 narH; respiratory nitrate reductase 1 beta chain K00371; COG: COG1140 Nitrate reductase beta subunit; Psort location: cytoplasmic, score: 23 YP_001570239.1 KEGG: stm:STM1762 5.1e-112 narJ; nitrate reductase delta chain K00373; COG: COG2180 Nitrate reductase delta subunit; Psort location: cytoplasmic, score: 23 YP_001570240.1 KEGG: stm:STM1761 9.7e-118 narI; nitrate reductase gamma chain K00374; COG: COG2181 Nitrate reductase gamma subunit; Psort location: plasma membrane, score: 23 YP_001570241.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001570242.1 KEGG: pen:PSEEN4477 0.00064 secA; preprotein translocase SecA subunit; COG: COG3012 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570243.1 KEGG: eci:UTI89_C1430 3.1e-137 ychK; hypothetical protein; COG: COG1752 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: cytoplasmic, score: 23 YP_001570244.1 KEGG: eci:UTI89_C1431 4.0e-160 rssB; RssB/Hnr protein K02485; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001570245.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001570246.1 COG: COG2916 DNA-binding protein H-NS; Psort location: nuclear, score: 23 YP_001570247.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001570248.1 KEGG: stm:STM1749 0. adhE; alcohol dehydrogenase / acetaldehyde dehydrogenase K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001570249.1 COG: COG2095 Multiple antibiotic transporter; Psort location: plasma membrane, score: 23 YP_001570250.1 Psort location: extracellular, including cell wall, score: 9 YP_001570251.1 KEGG: shn:Shewana3_2650 1.1e-20 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001570252.1 KEGG: rha:RHA1_ro09047 2.4e-43 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001570253.1 KEGG: baa:BA_0884 0.0024 binding-protein-dependent transport systems inner membrane component K00294; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001570254.1 KEGG: rru:Rru_A0589 1.3e-97 oligopeptide/dipeptide ABC transporter, ATP-binding protein-like K02031; COG: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001570255.1 KEGG: bur:Bcep18194_B0119 8.4e-96 oligopeptide/dipeptide ABC transporter, ATPase subunit K02032; COG: COG4608 ABC-type oligopeptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001570256.1 COG: COG1226 Kef-type K+ transport systems, predicted NAD-binding component; Psort location: endoplasmic reticulum, score: 9 YP_001570257.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_001570258.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001570259.1 Psort location: mitochondrial, score: 23 YP_001570260.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001570261.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_001570262.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_001570263.1 Involved in cell division; probably involved in intracellular septation YP_001570264.1 COG: NOG06197 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570265.1 COG: COG0727 Predicted Fe-S-cluster oxidoreductase; Psort location: nuclear, score: 23 YP_001570266.1 receptor for colicin S4 YP_001570267.1 KEGG: mfa:Mfla_1436 3.4e-108 catalase K00429; COG: COG3546 Mn-containing catalase; Psort location: mitochondrial, score: 23 YP_001570268.1 KEGG: rpe:RPE_3645 0.00022 catalase K00429; COG: COG3685 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001570269.1 KEGG: rpe:RPE_3645 2.8e-23 catalase K00429; COG: COG3685 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001570270.1 Psort location: cytoplasmic, score: 23 YP_001570271.1 COG: COG3729 General stress protein; Psort location: nuclear, score: 23 YP_001570272.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001570273.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001570274.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_001570275.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_001570276.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001570277.1 KEGG: reh:H16_A1200 1.8e-47 predicted metal-dependent phosphoesterase (PHP family); COG: COG0613 Predicted metal-dependent phosphoesterases (PHP family); Psort location: cytoplasmic, score: 23 YP_001570278.1 COG: COG0009 Putative translation factor (SUA5); Psort location: cytoplasmic, score: 23 YP_001570279.1 KEGG: nwi:Nwi_0782 0.0070 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001570280.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001570281.1 Psort location: cytoplasmic, score: 23 YP_001570282.1 Psort location: cytoplasmic, score: 23 YP_001570283.1 COG: COG3328 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001570284.1 Psort location: cytoplasmic, score: 23 YP_001570285.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_001570286.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001570287.1 KEGG: ecc:c1736 5.8e-120 yciK; short chain dehydrogenase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001570288.1 SohB; periplasmic protein; member of the peptidase S49 family YP_001570289.1 COG: NOG13548 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570290.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001570291.1 Psort location: mitochondrial, score: 23 YP_001570292.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_001570293.1 COG: NOG13876 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570294.1 Catalyzes the conversion of citrate to isocitrate YP_001570295.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001570296.1 KEGG: sty:STY1341 1.2e-135 pgpB; phosphatidylglycerophosphatase B K01096; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001570297.1 COG: COG3771 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001570298.1 KEGG: azo:azo1075 9.0e-60 conserved hypothetical transferase protein; COG: COG2956 Predicted N-acetylglucosaminyl transferase; Psort location: cytoplasmic, score: 23 YP_001570299.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001570300.1 involved in start site selection during the initiation of translation YP_001570301.1 COG: NOG17005 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570302.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001570303.1 COG: NOG34196 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570304.1 COG: COG2199 FOG: GGDEF domain; Psort location: nuclear, score: 23 YP_001570305.1 COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001570306.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_001570307.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001570308.1 COG: NOG18521 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570309.1 COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001570310.1 KEGG: hpa:HPAG1_0304 1.8e-52 dipeptide ABC transporter K00927; COG: COG4167 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: mitochondrial, score: 23 YP_001570311.1 KEGG: ret:RHE_CH00739 6.4e-66 dppDch1, dppFch1; dipeptide ABC transporter, ATP-binding protein K02031; COG: COG4170 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: nuclear, score: 23 YP_001570312.1 KEGG: lwe:lwe0999 0.00037 gbuB; glycine betaine/L-proline ABC transporter, permease protein; COG: COG4171 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001570313.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: extracellular, including cell wall, score: 9 YP_001570314.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001570315.1 COG: COG3547 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001570316.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001570317.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: cytoplasmic, score: 23 YP_001570318.1 Psort location: nuclear, score: 23 YP_001570319.1 COG: COG1961 Site-specific recombinases, DNA invertase Pin homologs; Psort location: cytoplasmic, score: 23 YP_001570320.1 Psort location: endoplasmic reticulum, score: 9 YP_001570321.1 KEGG: syf:Synpcc7942_2454 2.4e-27 adenine phosphoribosyltransferase K00759; COG: COG4168 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001570322.1 KEGG: shn:Shewana3_2650 1.9e-122 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001570323.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_001570324.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_001570325.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_001570326.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_001570327.1 COG: NOG14121 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570328.1 KEGG: ece:Z2475m 3.7e-228 glycosidase K00690; COG: COG0366 Glycosidases; Psort location: endoplasmic reticulum, score: 9 YP_001570329.1 KEGG: eci:UTI89_C1581 3.9e-201 ycjN; putative ABC transporter periplasmic binding protein YcjN precursor K02027; COG: COG1653 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001570330.1 KEGG: gvi:glr0748 0.00070 ndhC; NADH dehydrogenase subunit 3 K05574; COG: COG1175 ABC-type sugar transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001570331.1 COG: COG0395 ABC-type sugar transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001570332.1 KEGG: cvi:CV2051 6.1e-19 probable zinc-containing alcohol dehydrogenase K00001:K00002; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001570333.1 KEGG: eci:UTI89_C1585 1.9e-130 ycjR; putative transient receptor potential locus K01820; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001570334.1 KEGG: eco:b1315 7.2e-161 ycjS; predicted oxidoreductase, NADH-binding; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001570335.1 KEGG: eci:UTI89_C1587 1.7e-301 ycjT; hypothetical transport protein YcjT; COG: COG1554 Trehalose and maltose hydrolases (possible phosphorylases); Psort location: cytoplasmic, score: 23 YP_001570336.1 KEGG: eco:b1317 5.3e-78 ycjU, pgmB; putative beta phosphoglucomutase, contains a phophatase-like domain K01838; COG: COG0637 Predicted phosphatase/phosphohexomutase; Psort location: cytoplasmic, score: 23 YP_001570337.1 KEGG: sth:STH1782 7.6e-102 sugar ABC transportor ATP-binding protein K05816; COG: COG3839 ABC-type sugar transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001570338.1 Psort location: extracellular, including cell wall, score: 9 YP_001570339.1 KEGG: efa:EF1922 3.8e-09 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001570340.1 KEGG: sdy:SDY_1399 5.0e-240 ycjX; putative YcjX; COG: COG3106 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001570341.1 COG: COG3768 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001570342.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_001570343.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001570344.1 KEGG: sdy:SDY_1403 4.6e-143 ycjG; putative muconate cycloisomerase I; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001570345.1 COG: COG2866 Predicted carboxypeptidase; Psort location: cytoplasmic, score: 23 YP_001570346.1 COG: NOG34243 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570347.1 COG: NOG09971 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570348.1 Psort location: extracellular, including cell wall, score: 9 YP_001570349.1 Psort location: cytoplasmic, score: 23 YP_001570350.1 KEGG: shn:Shewana3_2650 1.7e-22 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001570351.1 KEGG: eco:b4249 3.9e-09 yjgI; predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001570352.1 Psort location: cytoplasmic, score: 23 YP_001570353.1 COG: NOG31342 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570354.1 KEGG: bcz:BCZK3497 9.7e-08 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001570355.1 Psort location: cytoskeletal, score: 9 YP_001570356.1 COG: NOG24375 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570357.1 KEGG: sha:SH0507 0.0094 hypothetical protein K00567; COG: NOG08628 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570358.1 COG: NOG25390 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570359.1 KEGG: mxa:MXAN_6496 0.0018 tpx; THIol peroxidase K00435; COG: COG2077 Peroxiredoxin; Psort location: cytoplasmic, score: 23 YP_001570360.1 COG: NOG18520 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570361.1 COG: COG3382 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570362.1 KEGG: psp:PSPPH_2917 7.1e-07 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: endoplasmic reticulum, score: 9 YP_001570363.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001570364.1 COG: NOG14120 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570365.1 with UspC and UspD is involved in resistance to UV irradiation YP_001570366.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_001570367.1 KEGG: stt:t1563 1.1e-86 ogt; O6-methylguanine-DNA-alkyltransferase K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001570368.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570369.1 KEGG: btl:BALH_1654 0.0048 vanS; sensor histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001570370.1 COG: COG0598 Mg2+ and Co2+ transporters; Psort location: cytoplasmic, score: 23 YP_001570371.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_001570372.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001570373.1 COG: NOG26587 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570374.1 COG: COG2076 Membrane transporters of cations and cationic drugs; Psort location: endoplasmic reticulum, score: 9 YP_001570375.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001570376.1 KEGG: spt:SPA1236 0. nifJ; probable pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: cytoplasmic, score: 23 YP_001570377.1 COG: COG3042 Putative hemolysin; Psort location: extracellular, including cell wall, score: 9 YP_001570378.1 KEGG: pmu:PM0180 0.0023 murZ; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790; COG: COG3187 Heat shock protein; Psort location: extracellular, including cell wall, score: 9 YP_001570379.1 KEGG: spt:SPA1239 3.0e-171 ldhA; D-lactate dehydrogenase K03778; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001570380.1 COG: NOG06225 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570381.1 COG: NOG17319 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570382.1 COG: COG3784 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001570383.1 KEGG: eci:UTI89_C1630 6.5e-73 ynbA; hypothetical protein YnbA K00995; COG: COG0558 Phosphatidylglycerophosphate synthase; Psort location: endoplasmic reticulum, score: 23 YP_001570384.1 KEGG: ype:YPO2816 5.9e-40 ynbB; putative phosphatidate cytidylyltransferase K00981; COG: COG4589 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase; Psort location: endoplasmic reticulum, score: 9 YP_001570385.1 COG: COG3791 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570386.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_001570387.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_001570388.1 COG: COG1434 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570389.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_001570390.1 KEGG: dar:Daro_3485 0.00060 probable phosphatidylethanolamine N-methyltransferase K00551; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001570391.1 KEGG: aha:AHA_3791 7.9e-22 phosphatidylcholine-sterol acyltransferase K00650; COG: COG3240 Phospholipase/leciTHInase/hemolysin; Psort location: cytoplasmic, score: 23 YP_001570392.1 COG: NOG06184 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570393.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001570395.1 Psort location: endoplasmic reticulum, score: 9 YP_001570396.1 COG: COG1937 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001570397.1 KEGG: stm:STM1627 5.0e-201 alcohol dehydrogenase class III K00001:K00121; COG: COG1062 Zn-dependent alcohol dehydrogenases, class III; Psort location: mitochondrial, score: 23 YP_001570398.1 KEGG: bxe:Bxe_C0521 0.00014 multi sensor hybrid histidine kinase; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001570399.1 KEGG: shn:Shewana3_3435 0.00016 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570400.1 COG: COG5383 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570401.1 KEGG: stm:STM1623 2.3e-258 putative carboxylesterase K03927; COG: COG2272 Carboxylesterase type B; Psort location: cytoplasmic, score: 23 YP_001570402.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_001570403.1 KEGG: wsu:WS2019 0.0036 ribD; putative riboflavin-specific deaminase K00082:K01498; Psort location: cytoplasmic, score: 23 YP_001570404.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001570405.1 COG: COG1363 Cellulase M and related proteins; Psort location: cytoplasmic, score: 23 YP_001570406.1 KEGG: nar:Saro_2593 0.0073 propionyl-CoA carboxylase K01964; Psort location: mitochondrial, score: 23 YP_001570407.1 KEGG: mja:MJ0555 0.0034 endoglucanase K01179; COG: COG1363 Cellulase M and related proteins; Psort location: cytoplasmic, score: 23 YP_001570408.1 KEGG: sty:STY1453 4.1e-87 rimL; ribosomal-protein-serine acetyltransferase K03817; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001570409.1 COG: COG1275 Tellurite resistance protein and related permeases; Psort location: endoplasmic reticulum, score: 9 YP_001570410.1 with TehA confers resistance to tellurite YP_001570411.1 COG: NOG06284 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570412.1 COG: COG3135 Uncharacterized protein involved in benzoate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001570413.1 COG: COG1396 Predicted transcriptional regulators; Psort location: extracellular, including cell wall, score: 9 YP_001570414.1 KEGG: sec:SC1601 0. ydcP; putative collagenase K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001570415.1 COG: NOG18519 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570416.1 translocated by the type III secretion system SPI-2; localizes to Sifs in infected cells and specifically to Salmonella-containing vacuoles YP_001570417.1 COG: NOG27850 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570418.1 KEGG: stt:t1508 3.8e-100 pcgL; D-alanyl-D-alanine dipeptidase K08641; COG: COG2173 D-alanyl-D-alanine dipeptidase; Psort location: extracellular, including cell wall, score: 9 YP_001570419.1 KEGG: eci:UTI89_C1658 4.8e-212 ydcR; hypothetical protein YdcR K00811; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001570420.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_001570421.1 COG: NOG12162 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570422.1 COG: COG4458 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: cytoplasmic, score: 23 YP_001570423.1 COG: COG4457 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: cytoplasmic, score: 23 YP_001570424.1 COG: NOG35976 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570425.1 COG: NOG13890 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570426.1 COG: COG3238 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001570427.1 KEGG: stm:STM1590 1.1e-88 yncA; putative acyltransferase K03823; COG: COG1247 Sortase and related acyltransferases; Psort location: cytoskeletal, score: 9 YP_001570428.1 KEGG: stm:STM1589 2.6e-188 yncB; putative NADP-dependent oxidoreductase; COG: COG2130 Putative NADP-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001570429.1 Psort location: cytoplasmic, score: 23 YP_001570430.1 KEGG: msm:MSMEG_3400 8.3e-08 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001570431.1 KEGG: shn:Shewana3_3063 0.0041 phosphatidylglycerophosphatase K01094; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001570432.1 COG: COG3391 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570433.1 COG: COG1309 Transcriptional regulator; Psort location: vesicles of secretory system, score: 9 YP_001570434.1 KEGG: shn:Shewana3_1692 0.00039 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001570435.1 COG: COG3791 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001570436.1 COG: COG3203 Outer membrane protein (porin); Psort location: mitochondrial, score: 23 YP_001570437.1 Psort location: cytoplasmic, score: 23 YP_001570438.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001570439.1 KEGG: stm:STM1569 4.6e-166 fdnH; formate dehydrogenase, iron-sulfur subunit (formate dehydrogenase beta subunit) K08349; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001570440.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_001570441.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_001570442.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001570443.1 Psort location: cytoplasmic, score: 23 YP_001570444.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase YP_001570445.1 COG: NOG14119 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570446.1 Psort location: nuclear, score: 23 YP_001570447.1 KEGG: pfl:PFL_0043 1.7e-42 osmC; hydroperoxide resistance protein OsmC K04063; COG: COG1764 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001570448.1 COG: NOG11340 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570449.1 COG: NOG09007 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570450.1 KEGG: sme:SMb21447 4.3e-147 glgB2; putative 1,4-alpha-glucan branching enzyme protein K00700; COG: COG0296 1,4-alpha-glucan branching enzyme; Psort location: endoplasmic reticulum, score: 9 YP_001570451.1 KEGG: ret:RHE_PE00008 4.7e-205 putative maltooligosyl trehalose synthase protein; COG: COG3280 Maltooligosyl trehalose synthase; Psort location: cytoplasmic, score: 23 YP_001570452.1 KEGG: stm:STM1558 0. putative glycosyl hydrolase K02438; COG: COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; Psort location: cytoskeletal, score: 9 YP_001570453.1 KEGG: spt:SPA1313 1.7e-216 putative aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001570454.1 COG: COG1757 Na+/H+ antiporter; Psort location: plasma membrane, score: 23 YP_001570455.1 KEGG: efa:EF1922 7.0e-07 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001570456.1 COG: COG3654 Prophage maintenance system killer protein; Psort location: cytoplasmic, score: 23 YP_001570457.1 COG: COG2161 Antitoxin of toxin-antitoxin stability system; Psort location: mitochondrial, score: 23 YP_001570458.1 Psort location: cytoplasmic, score: 23 YP_001570459.1 Psort location: cytoplasmic, score: 23 YP_001570460.1 KEGG: yps:YPTB3882 6.0e-228 hsdM; putative type I site-specific deoxyribonuclease LldI chain K03427; COG: COG0286 Type I restriction-modification system methyltransferase subunit; Psort location: cytoplasmic, score: 23 YP_001570461.1 KEGG: gox:GOX2568 2.7e-42 type I restriction-modification enzyme S subunit K01154; COG: COG0732 Restriction endonuclease S subunits; Psort location: nuclear, score: 23 YP_001570462.1 KEGG: yps:YPTB3879 0. possible type I restriction enzyme (restriction subunit) K01153; COG: COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; Psort location: cytoplasmic, score: 23 YP_001570463.1 COG: COG0038 Chloride channel protein EriC; Psort location: mitochondrial, score: 23 YP_001570464.1 Psort location: nuclear, score: 23 YP_001570465.1 KEGG: bur:Bcep18194_C7553 1.8e-132 ABC glycine betaine/L-proline transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001570466.1 KEGG: lwe:lwe1439 1.3e-42 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001570467.1 KEGG: lwe:lwe1443 4.7e-31 opuCC; glycine betaine/L-proline ABC transporter, glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001570468.1 KEGG: lwe:lwe1439 2.5e-39 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001570469.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_001570470.1 KEGG: eci:UTI89_C1777 1.5e-119 ynfH; anaerobic dimethyl sulfoxide reductase chain YnfH K07312; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001570471.1 KEGG: ecp:ECP_0909 4.3e-115 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001570472.1 KEGG: stm:STM1498 0. putative dimethyl sulphoxide reductase K07310; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001570473.1 Psort location: cytoplasmic, score: 23 YP_001570474.1 KEGG: stm:STM1499 0. putative dimethyl sulphoxide reductase, chain A1 K07309; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001570475.1 COG: NOG12175 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570476.1 COG: NOG06202 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570477.1 KEGG: sec:SC1519 3.5e-97 speG; spermidine N1-acetyltransferase K00657; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001570478.1 COG: NOG11441 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570479.1 COG: COG1742 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 23 YP_001570480.1 KEGG: eci:UTI89_C1768 2.1e-218 rspA; starvation sensing protein RspA K08323; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001570481.1 KEGG: stm:STM1506 4.0e-176 rspB; putative dehydrogenase K08322; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001570482.1 KEGG: cal:orf19.2425 6.2e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001570483.1 Psort location: cytoplasmic, score: 23 YP_001570484.1 KEGG: spt:SPA1347 2.2e-255 ydfI; putative mannitol dehydrogenase K00040; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001570485.1 COG: NOG13886 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570486.1 KEGG: msm:MSMEG_3400 3.2e-08 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001570487.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_001570488.1 KEGG: stt:t1433 0. dcp; dipeptidyl carboxypeptidase II K01284; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001570489.1 Psort location: cytoplasmic, score: 23 YP_001570490.1 COG: COG3729 General stress protein; Psort location: nuclear, score: 23 YP_001570491.1 COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: cytoplasmic, score: 23 YP_001570492.1 COG: COG3111 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001570493.1 Psort location: cytoplasmic, score: 23 YP_001570494.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_001570495.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_001570496.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function YP_001570497.1 KEGG: dre:30298 1.2e-06 jak2b; Janus kinase 2b K04447; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001570498.1 KEGG: shn:Shewana3_3435 2.3e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570499.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_001570500.1 catalyzes the formation of glutamate from glutamine YP_001570501.1 COG: NOG13916 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570502.1 COG: NOG26587 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570503.1 COG: COG3203 Outer membrane protein (porin); Psort location: cytoplasmic, score: 23 YP_001570504.1 COG: COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); Psort location: cytoplasmic, score: 23 YP_001570505.1 COG: NOG36839 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570506.1 KEGG: eci:UTI89_C1045 6.2e-36 hyaF; hydrogenase-1 operon protein HyaF K03618; COG: COG1773 Rubredoxin; Psort location: extracellular, including cell wall, score: 9 YP_001570507.1 COG: NOG22061 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570508.1 COG: NOG17080 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570509.1 KEGG: sec:SC1553 1.1e-102 hupD; putative hydrogenase maturation protease K03605; COG: COG0680 Ni,Fe-hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001570510.1 KEGG: eci:UTI89_C1042 1.7e-65 hyaC; probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit K03620; COG: COG1969 Ni,Fe-hydrogenase I cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001570511.1 KEGG: stm:STM1538 0. hydrogenase large chain K06281; COG: COG0374 Ni,Fe-hydrogenase I large subunit; Psort location: cytoplasmic, score: 23 YP_001570512.1 KEGG: stm:STM1539 7.5e-182 hydrogenase small chain K06282; COG: COG1740 Ni,Fe-hydrogenase I small subunit; Psort location: cytoplasmic, score: 23 YP_001570513.1 COG: COG4287 PhoPQ-activated pathogenicity-related protein; Psort location: endoplasmic reticulum, score: 9 YP_001570514.1 COG: COG3109 Activator of osmoprotectant transporter ProP; Psort location: cytoplasmic, score: 23 YP_001570515.1 Psort location: cytoplasmic, score: 23 YP_001570516.1 KEGG: shn:Shewana3_3435 1.3e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570517.1 KEGG: sec:SC2614 1.4e-13 lycV; Gifsy-2 prophage lysozyme K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: cytoplasmic, score: 23 YP_001570518.1 COG: NOG27507 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570519.1 COG: NOG06259 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001570520.1 COG: NOG06167 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570521.1 COG: COG3179 Predicted chitinase; Psort location: mitochondrial, score: 23 YP_001570522.1 Psort location: cytoplasmic, score: 23 YP_001570523.1 Psort location: cytoplasmic, score: 23 YP_001570524.1 KEGG: sat:SYN_02061 2.4e-18 zinc metalloprotease; COG: COG1451 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001570525.1 KEGG: yps:YPTB3879 1.8e-123 possible type I restriction enzyme (restriction subunit) K01153; COG: COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; Psort location: cytoplasmic, score: 23 YP_001570526.1 KEGG: cpr:CPR_1400 1.7e-27 chloride channel protein K01529; COG: COG0038 Chloride channel protein EriC; Psort location: plasma membrane, score: 23 YP_001570527.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001570528.1 KEGG: eci:UTI89_C1781 1.8e-196 mlc; putative NAGC-like transcriptional regulator K00845; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001570529.1 KEGG: shn:Shewana3_3435 1.6e-21 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570530.1 KEGG: shn:Shewana3_1692 3.9e-50 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001570531.1 required for growth and survival under moderately acid conditions YP_001570532.1 KEGG: spt:SPA1370 4.0e-144 putative secreted protein K04775; COG: COG3591 V8-like Glu-specific endopeptidase; Psort location: extracellular, including cell wall, score: 9 YP_001570533.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_001570534.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS YP_001570535.1 Psort location: cytoplasmic, score: 23 YP_001570536.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_001570537.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001570538.1 COG: NOG06063 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570539.1 KEGG: eci:UTI89_C0120 1.6e-08 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001570540.1 COG: COG3136 Uncharacterized membrane protein required for alginate biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001570541.1 response regulator in two-component regulatory system with RstB YP_001570542.1 Psort location: cytoplasmic, score: 23 YP_001570543.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001570544.1 KEGG: spt:SPA1384 5.8e-223 rstB; two component sensor kinase K07639; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001570545.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_001570546.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001570547.1 Psort location: cytoplasmic, score: 23 YP_001570548.1 KEGG: spt:SPA1387 3.1e-295 fumA; Fumarate hydratase class I, aerobic K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001570549.1 KEGG: stm:STM1467 7.1e-202 manA; mannose-6-phosphate isomerase K01809; COG: COG1482 Phosphomannose isomerase; Psort location: cytoplasmic, score: 23 YP_001570550.1 COG: COG5339 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001570551.1 regulates malXY which are involved in maltose-glucose transport YP_001570552.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site YP_001570553.1 KEGG: ece:Z2627 1.9e-176 malY; enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase K01760; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001570554.1 Psort location: cytoplasmic, score: 23 YP_001570555.1 KEGG: stt:t1331 1.8e-141 add; adenosine deaminase K01488; COG: COG1816 Adenosine deaminase; Psort location: cytoplasmic, score: 23 YP_001570556.1 KEGG: eci:UTI89_C1812 6.2e-171 ydgJ; hypothetical oxidoreductase YdgJ; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoskeletal, score: 9 YP_001570557.1 Psort location: endoplasmic reticulum, score: 9 YP_001570558.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes YP_001570559.1 COG: NOG08686 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570560.1 KEGG: vfi:VF0935 2.6e-78 Na(+)-translocating NADH-quinone reductase subunit E K03617; COG: COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Psort location: plasma membrane, score: 23 YP_001570561.1 Psort location: cytoplasmic, score: 23 YP_001570562.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001570563.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001570564.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_001570565.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_001570566.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001570567.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines YP_001570568.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_001570569.1 KEGG: stm:STM1451 2.0e-101 gst; glutaTHIonine S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001570570.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001570571.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001570572.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001570573.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_001570574.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001570575.1 COG: COG3133 Outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001570576.1 Transcription regulator that can both activate or repress expression YP_001570577.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001570578.1 COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001570579.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_001570580.1 KEGG: ecc:c2039 9.5e-143 ydhF; hypothetical oxidoreductase YdhF; COG: COG4989 Predicted oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001570581.1 Psort location: cytoplasmic, score: 23 YP_001570582.1 KEGG: bpm:BURPS1710b_A2293 5.6e-35 TetR-family regulatory protein K00356; COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570583.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_001570584.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_001570585.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001570586.1 KEGG: ama:AM1083 1.2e-07 grxC1; glutaredoxin 3 K03676; COG: COG0278 Glutaredoxin-related protein; Psort location: cytoplasmic, score: 23 YP_001570587.1 Psort location: cytoplasmic, score: 23 YP_001570588.1 KEGG: ssn:SSO_1501 3.9e-75 ydhO; putative lipoprotein K01183; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: mitochondrial, score: 23 YP_001570589.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_001570590.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_001570591.1 KEGG: shn:Shewana3_3435 0.00016 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570592.1 uncharacterized member of the major facilitator superfamily (MFS) YP_001570593.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_001570594.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001570595.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001570596.1 member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli YP_001570597.1 COG: COG4791 Type III secretory pathway, component EscT; Psort location: plasma membrane, score: 23 YP_001570598.1 COG: COG4794 Type III secretory pathway, component EscS; Psort location: cytoplasmic, score: 23 YP_001570599.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response YP_001570600.1 COG: COG1886 Flagellar motor switch/type III secretory pathway protein; Psort location: cytoplasmic, score: 23 YP_001570601.1 COG: NOG24542 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570602.1 COG: NOG23008 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570603.1 KEGG: stt:t1283 5.1e-215 ssaN; putative type III secretion ATP synthase K03224; COG: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; Psort location: cytoplasmic, score: 23 YP_001570604.1 with SsaC forms part of a protein export system across the inner and outer cell membranes; part of the Salmonella pathogenicity island 2; part of the type III secretion system YP_001570605.1 COG: NOG09839 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570606.1 COG: NOG14113 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570607.1 COG: NOG12246 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570608.1 COG: COG4669 Type III secretory pathway, lipoprotein EscJ; Psort location: extracellular, including cell wall, score: 23 YP_001570609.1 COG: NOG38377 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570610.1 COG: NOG22388 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570611.1 COG: NOG18517 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570612.1 COG: NOG26042 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570613.1 COG: NOG26742 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570614.1 KEGG: ter:Tery_0416 8.9e-07 1-deoxy-D-xylulose 5-phosphate reductoisomerase K00099; COG: COG0457 FOG: TPR repeat; Psort location: cytoplasmic, score: 23 YP_001570615.1 COG: NOG20797 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570616.1 COG: NOG18516 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570617.1 COG: COG5613 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570618.1 COG: COG0457 FOG: TPR repeat; Psort location: cytoplasmic, score: 23 YP_001570619.1 COG: NOG20796 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570620.1 COG: NOG23007 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570621.1 COG: NOG24541 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570622.1 COG: NOG08735 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570623.1 COG: COG1450 Type II secretory pathway, component PulD; Psort location: nuclear, score: 23 YP_001570624.1 COG: NOG20795 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570625.1 KEGG: sec:SC1413 0. ssrA; secretion system regulator:sensor component K00873; COG: COG0784 FOG: CheY-like receiver; Psort location: endoplasmic reticulum, score: 9 YP_001570626.1 KEGG: pha:PSHAa1916 8.1e-27 uvrY, sirA; response regulator K07689; COG: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001570627.1 KEGG: eci:UTI89_C3737 3.0e-06 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: vesicles of secretory system, score: 9 YP_001570628.1 KEGG: ctc:CTC02272 0.0015 purine nucleoside phosphorylase K00755; COG: COG3272 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570629.1 Psort location: cytoplasmic, score: 23 YP_001570630.1 COG: NOG13889 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570631.1 KEGG: rru:Rru_A1500 6.4e-19 signal transduction histidine kinase (STHK) with CheB and CheR activity K03412:K00575; COG: COG4566 Response regulator; Psort location: cytoplasmic, score: 23 YP_001570632.1 KEGG: stm:STM1386 7.2e-280 ttrS; sensory histidine kinase K00873; COG: COG0642 Signal transduction histidine kinase; Psort location: cytoplasmic, score: 23 YP_001570633.1 KEGG: pai:PAE1263 1.4e-45 molybdopterin oxidoreductase, iron-sulfur binding subunit K00184; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001570634.1 KEGG: pai:PAE2861 3.5e-06 molybdopterin oxidoreductase, membrane subunit K00185; COG: NOG06755 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001570635.1 KEGG: afu:AF0159 6.0e-95 molybdopterin oxidoreductase, molybdopterin binding subunit K00183; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: extracellular, including cell wall, score: 9 YP_001570636.1 Psort location: nuclear, score: 23 YP_001570637.1 COG: COG0531 Amino acid transporters; Psort location: endoplasmic reticulum, score: 9 YP_001570638.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001570639.1 COG: COG4238 Murein lipoprotein; Psort location: nuclear, score: 23 YP_001570640.1 KEGG: eci:UTI89_C2228 2.9e-63 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001570641.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_001570642.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_001570643.1 with SufBC activates cysteine desulfurase SufS YP_001570644.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_001570645.1 with SufCD activates cysteine desulfurase SufS YP_001570646.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_001570647.1 KEGG: eci:UTI89_C4668 0.00083 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: endoplasmic reticulum, score: 9 YP_001570648.1 COG: NOG11331 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570649.1 KEGG: eco:b1686 4.1e-64 ydiI; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001570650.1 KEGG: eci:UTI89_C1879 0. ydiJ; hypothetical protein YdiJ; COG: COG0247 Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001570651.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_001570652.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_001570653.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001570654.1 Psort location: mitochondrial, score: 23 YP_001570655.1 COG: COG1806 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570656.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_001570657.1 COG: COG4256 Hemin uptake protein; Psort location: nuclear, score: 23 YP_001570658.1 COG: COG0397 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570659.1 COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001570660.1 KEGG: eci:UTI89_C1901 9.5e-72 nlpC; probable lipoprotein NlpC precursor; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001570661.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_001570662.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_001570663.1 with BtuD and BtuF transports vitamin B12 into the cell YP_001570664.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001570665.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001570666.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001570667.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001570668.1 COG: COG0291 Ribosomal protein L35; Psort location: cytoplasmic, score: 23 YP_001570669.1 Psort location: cytoplasmic, score: 23 YP_001570670.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001570671.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001570672.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001570673.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001570674.1 COG: NOG21841 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570675.1 COG: NOG26807 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570676.1 KEGG: spt:SPA3566 1.7e-113 waaK; lipopolysaccharide 1,2-N-acetylglucosaminetransferase K03280; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001570677.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001570678.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001570679.1 COG: NOG14667 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570680.1 KEGG: pat:Patl_0573 7.7e-38 endonuclease; COG: COG1864 DNA/RNA endonuclease G, NUC1; Psort location: nuclear, score: 23 YP_001570681.1 Psort location: mitochondrial, score: 23 YP_001570682.1 COG: COG3528 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570683.1 COG: COG3137 Putative salt-induced outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001570684.1 KEGG: stm:STM1326 3.8e-155 pfkB; 6-phosphofructokinase II K00850; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: extracellular, including cell wall, score: 9 YP_001570685.1 COG: NOG12163 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570686.1 KEGG: eci:UTI89_C1919 2.9e-148 yniA; hypothetical protein YniA K00924; COG: COG3001 Fructosamine-3-kinase; Psort location: cytoplasmic, score: 23 YP_001570687.1 COG: NOG07880 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001570688.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_001570689.1 COG: COG1988 Predicted membrane-bound metal-dependent hydrolases; Psort location: cytoplasmic, score: 23 YP_001570690.1 KEGG: eci:UTI89_C4668 1.7e-35 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: plasma membrane, score: 23 YP_001570691.1 COG: NOG11329 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570692.1 Psort location: cytoskeletal, score: 9 YP_001570693.1 KEGG: sec:SC1339 1.3e-27 katE; catalase; hydroperoxidase HPII(III), RpoS dependent K03781; COG: COG0753 Catalase; Psort location: mitochondrial, score: 23 YP_001570694.1 KEGG: eci:UTI89_C1926 3.5e-106 ydjC; hypothetical protein YdjC K03478; COG: COG3394 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570695.1 KEGG: sec:SC1337 3.5e-239 celF; phospho-beta-glucosidase (cellobiose-6-phosphate hydrolase) K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001570696.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_001570697.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001570698.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001570699.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001570700.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_001570701.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001570702.1 3' incision activity; acts with UvrC YP_001570703.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_001570704.1 Psort location: mitochondrial, score: 23 YP_001570705.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_001570706.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_001570707.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_001570708.1 KEGG: spt:SPA1540 1.4e-182 astA; arginine succinyltransferase K00673; COG: COG3138 Arginine/orniTHIne N-succinyltransferase beta subunit; Psort location: cytoplasmic, score: 23 YP_001570709.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_001570710.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001570711.1 KEGG: sec:SC1323 4.2e-69 nudG; putative mutator MutT protein K08320; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001570712.1 COG: NOG11328 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570713.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001570714.1 decatenates replicating daughter chromosomes YP_001570715.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001570716.1 KEGG: sbo:SBO_1322 2.3e-86 ydjA; hypothetical protein; COG: COG0778 Nitroreductase; Psort location: cytoplasmic, score: 23 YP_001570717.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_001570718.1 converts asparagine to aspartate and ammonia YP_001570719.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_001570720.1 COG: COG3139 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001570721.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_001570722.1 KEGG: stt:t1169 5.9e-95 gapA; glyceraldehyde 3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001570723.1 KEGG: ecs:ECs2488 4.6e-56 glyceraldehyde-3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001570724.1 KEGG: tbd:Tbd_2730 1.2e-34 dihydroxy-acid dehydratase K01687; COG: COG0676 Uncharacterized enzymes related to aldose 1-epimerase; Psort location: cytoplasmic, score: 23 YP_001570725.1 KEGG: reh:H16_A3186 2.0e-78 aldehyde reductase, related to diketogulonate reductase K00011; COG: COG0656 Aldo/keto reductases, related to diketogulonate reductase; Psort location: cytoplasmic, score: 23 YP_001570726.1 COG: COG3713 Outer membrane protein V; Psort location: extracellular, including cell wall, score: 9 YP_001570727.1 KEGG: eci:UTI89_C1979 0. yeaG; hypothetical protein K07180; COG: COG2766 Putative Ser protein kinase; Psort location: cytoplasmic, score: 23 YP_001570728.1 KEGG: eci:UTI89_C1980 1.1e-214 yeaH; hypothetical protein YeaH K00754; COG: COG2718 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001570729.1 KEGG: eci:UTI89_C1612 2.6e-13 ydaM; hypothetical protein YdaM; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001570730.1 COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570731.1 COG: COG2707 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001570732.1 KEGG: rfe:RF_0915 0.0075 methylated-DNA--protein-cysteine methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001570733.1 KEGG: dre:30298 5.1e-05 jak2b; Janus kinase 2b K04447; COG: COG2807 Cyanate permease; Psort location: plasma membrane, score: 23 YP_001570734.1 KEGG: eci:UTI89_C1988 4.5e-42 yeaO; hypothetical protein K00589; COG: COG3189 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570735.1 COG: NOG29442 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570736.1 COG: COG3042 Putative hemolysin; Psort location: nuclear, score: 23 YP_001570737.1 Psort location: cytoplasmic, score: 23 YP_001570738.1 Psort location: endoplasmic reticulum, score: 9 YP_001570739.1 KEGG: bja:bll5026 0.0049 rrpP; H+ translocating pyrophosphate synthase K01507; COG: COG2261 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001570740.1 COG: NOG24806 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570741.1 COG: COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance; Psort location: cytoplasmic, score: 23 YP_001570742.1 COG: COG1280 Putative threonine efflux protein; Psort location: plasma membrane, score: 23 YP_001570743.1 KEGG: bur:Bcep18194_A3548 6.5e-18 ABC amino acid transporter, periplasmic ligand binding protein K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001570744.1 catalyzes the interconversion of chorismate to prephenate YP_001570745.1 COG: NOG23111 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570746.1 Psort location: nuclear, score: 23 YP_001570747.1 COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001570748.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001570749.1 KEGG: stm:STM1264 1.3e-21 aadA; Aminoglycoside adenyltransferase K00984; COG: COG1708 Predicted nucleotidyltransferases; Psort location: mitochondrial, score: 23 YP_001570750.1 COG: COG3443 Predicted periplasmic or secreted protein; Psort location: cytoplasmic, score: 23 YP_001570751.1 KEGG: mja:MJ0155 0.0015 formate dehydrogenase, iron-sulfur subunit K00124; COG: COG1145 Ferredoxin; Psort location: nuclear, score: 23 YP_001570752.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: endoplasmic reticulum, score: 9 YP_001570753.1 KEGG: ava:Ava_B0212 9.6e-40 ABC transporter-like K02032; COG: COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001570754.1 KEGG: ava:Ava_B0213 6.6e-32 oligopeptide/dipeptide ABC transporter, ATP-binding protein-like K02031; COG: COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase; Psort location: cytoplasmic, score: 23 YP_001570755.1 COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 23 YP_001570756.1 KEGG: rha:RHA1_ro09047 1.2e-32 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001570757.1 KEGG: shn:Shewana3_2650 4.8e-07 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001570758.1 COG: NOG18515 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570759.1 KEGG: eci:UTI89_C0678 3.6e-19 hypothetical protein K01186; COG: COG4692 Predicted neuraminidase (sialidase); Psort location: endoplasmic reticulum, score: 9 YP_001570760.1 COG: COG0071 Molecular chaperone (small heat shock protein); Psort location: cytoplasmic, score: 23 YP_001570761.1 Psort location: endoplasmic reticulum, score: 9 YP_001570762.1 COG: NOG33500 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570763.1 Psort location: cytoplasmic, score: 23 YP_001570764.1 PliC; periplasmic lysozyme inhibitor of c-type lysozyme YP_001570765.1 COG: COG3637 Opacity protein and related surface antigens; Psort location: endoplasmic reticulum, score: 9 YP_001570766.1 COG: NOG33321 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570767.1 COG: NOG30737 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570768.1 Psort location: cytoplasmic, score: 23 YP_001570769.1 KEGG: sde:Sde_3710 9.6e-08 arabinogalactan endo-1,4-beta-galactosidase K01224; COG: NOG25721 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570770.1 COG: NOG15335 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570771.1 KEGG: nma:NMA0905 5.0e-94 iga; IgA1 protease K01347; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: nuclear, score: 23 YP_001570772.1 COG: NOG10257 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570773.1 COG: NOG23112 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570774.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_001570775.1 Psort location: nuclear, score: 23 YP_001570776.1 KEGG: rbe:RBE_0581 1.7e-26 mccF; microcin C7 self-immunity protein K01297; COG: COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF; Psort location: cytoplasmic, score: 23 YP_001570777.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001570778.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001570779.1 COG: NOG26051 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570780.1 Converts isocitrate to alpha ketoglutarate YP_001570781.1 KEGG: stm:STM1237 4.6e-111 ymfC; putative ribosomal large subunit pseudouridine synthase K06181; COG: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Psort location: cytoplasmic, score: 23 YP_001570782.1 COG: COG4461 Uncharacterized protein conserved in bacteria, putative lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001570783.1 KEGG: stm:STM1235 5.7e-81 ymfB; putative MutT-like protein; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001570784.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001570785.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001570786.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001570787.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_001570788.1 KEGG: spt:SPA1620 3.2e-254 phoQ; sensor protein PhoQ, regulator of virulence determinants K07637; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 23 YP_001570789.1 COG: COG2850 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570790.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001570791.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001570792.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_001570793.1 Psort location: cytoplasmic, score: 23 YP_001570794.1 translocated by the type III secretion system SPI-2; required for the formation of lysosomal glycoprotein structures (Sifs); required for maintenance of membrane in the Salmonella-containing vacuole; a cysteine residue with CAAX motif is modified by isoprenoid addition of protein geranylgeranyl transferase I; also modified by S-acylation YP_001570795.1 Psort location: cytoplasmic, score: 23 YP_001570796.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001570797.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_001570798.1 KEGG: stt:t1699 1.4e-125 cobB; putative regulatory protein K01463; COG: COG0846 NAD-dependent protein deacetylases, SIR2 family; Psort location: cytoplasmic, score: 23 YP_001570799.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_001570800.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001570801.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone YP_001570802.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001570803.1 KEGG: eci:UTI89_C1242 0. mfd; transcription-repair coupling factor; mutation frequency decline K03723; COG: COG1197 Transcription-repair coupling factor (superfamily II helicase); Psort location: cytoplasmic, score: 23 YP_001570804.1 KEGG: eci:UTI89_C2228 4.9e-68 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001570805.1 KEGG: reu:Reut_B4338 0.0018 copper/zinc superoxide dismutase K04565; COG: NOG13874 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570806.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001570807.1 COG: COG3134 Predicted outer membrane lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001570808.1 KEGG: stt:t1709 2.0e-229 ndh; NADH dehydrogenase K03885; COG: COG1252 NADH dehydrogenase, FAD-containing subunit; Psort location: cytoskeletal, score: 9 YP_001570809.1 COG: COG3150 Predicted esterase; Psort location: cytoplasmic, score: 23 YP_001570810.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001570811.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_001570812.1 COG: COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family); Psort location: extracellular, including cell wall, score: 9 YP_001570813.1 COG: COG5633 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001570814.1 KEGG: eci:UTI89_C1231 5.1e-57 ycfF; HIT-like protein YcfF K01518; COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: cytoplasmic, score: 23 YP_001570815.1 COG: COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid; Psort location: mitochondrial, score: 23 YP_001570816.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001570817.1 Psort location: cytoplasmic, score: 23 YP_001570818.1 KEGG: sec:SC1152 1.5e-137 ycfH; putative metal-dependent hydrolase K03424; COG: COG0084 Mg-dependent DNase; Psort location: cytoplasmic, score: 23 YP_001570819.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001570820.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001570821.1 KEGG: eci:UTI89_C1224 1.8e-157 yceG; putative thymidylate kinase; COG: COG1559 Predicted periplasmic solute-binding protein; Psort location: extracellular, including cell wall, score: 23 YP_001570822.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_001570823.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001570824.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: endoplasmic reticulum, score: 9 YP_001570825.1 KEGG: ddi:DDB0230105 0.0030 putative CLK family kinase K08287; COG: COG3188 P pilus assembly protein, porin PapC; Psort location: cytoplasmic, score: 23 YP_001570826.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: cytoplasmic, score: 23 YP_001570827.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001570828.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001570829.2 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001570830.1 KEGG: eci:UTI89_C1220 1.7e-35 acpP; acyl carrier protein K02078; COG: COG0236 Acyl carrier protein; Psort location: cytoplasmic, score: 23 YP_001570831.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001570832.1 KEGG: stm:STM1194 1.7e-159 fabD; malonyl-CoA-[acyl-carrier-protein] transacylase K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: cytoplasmic, score: 23 YP_001570833.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001570834.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001570835.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001570836.1 COG: COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; Psort location: cytoplasmic, score: 23 YP_001570837.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001570838.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_001570839.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_001570840.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_001570841.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001570842.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_001570843.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001570844.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_001570845.1 makes up the distal portion of the flagellar basal body rod YP_001570846.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_001570847.1 the hook connects flagellar basal body to the flagellar filament YP_001570848.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_001570849.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001570850.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_001570851.1 required for the assembly of the flagellar basal body P-ring YP_001570852.1 regulates the flagellar specific sigma28 transcription factor YP_001570853.1 COG: COG3418 Flagellar biosynthesis/type III secretory pathway chaperone; Psort location: nuclear, score: 23 YP_001570854.1 COG: COG0728 Uncharacterized membrane protein, putative virulence factor; Psort location: plasma membrane, score: 23 YP_001570855.1 KEGG: lpl:lp_0813 2.0e-30 oxidoreductase (putative) K03810; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001570856.1 COG: COG3132 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001570857.1 KEGG: sec:SC1115 7.2e-106 rimJ; acetylation of N-terminal alanine of 30S ribosomal subunit protein S5 K03790; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001570858.1 Confers resistance to norfloxacin and enoxacin YP_001570859.1 cofactor involved in the reduction of disulfides YP_001570860.1 COG: NOG07875 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001570861.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001570862.1 COG: NOG13873 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570863.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001570864.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_001570865.1 Psort location: nuclear, score: 23 YP_001570866.1 Psort location: cytoplasmic, score: 23 YP_001570867.1 KEGG: reh:H16_A3123 1.0e-26 cytochrome b561 K00156; COG: COG3038 Cytochrome B561; Psort location: endoplasmic reticulum, score: 9 YP_001570868.1 COG: COG2353 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001570869.1 KEGG: pub:SAR11_1074 3.2e-23 yceA; rhodanese domain protein; COG: COG1054 Predicted sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001570870.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001570871.1 Confers resistance to fosfomycin and deoxycholate YP_001570872.1 COG: NOG09842 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570873.1 COG: COG5645 Predicted periplasmic lipoprotein; Psort location: mitochondrial, score: 23 YP_001570874.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001570875.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_001570876.1 required for the transfer of succinyl residues to the glucan backbone YP_001570877.1 KEGG: reh:H16_B1107 3.5e-106 phospholipase D K01115; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: cytoplasmic, score: 23 YP_001570878.1 KEGG: reh:H16_A1552 1.1e-45 predicted phosphatase homolog to the C-terminal domain of histone macroH2A1; COG: COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1; Psort location: cytoplasmic, score: 23 YP_001570879.1 COG: NOG18522 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570880.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_001570881.1 COG: NOG09021 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570882.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_001570883.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: mitochondrial, score: 23 YP_001570884.1 COG: NOG08684 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570885.1 COG: NOG09737 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570886.1 KEGG: vfi:VFA0083 5.7e-10 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001570887.1 KEGG: eci:UTI89_C1155 2.2e-120 ycdX; hypothetical protein K04477; COG: COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Psort location: cytoplasmic, score: 23 YP_001570888.1 KEGG: eco:b1033 1.4e-134 ycdW; 2-ketoacid reductase K00049; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001570889.1 Psort location: nuclear, score: 23 YP_001570890.1 COG: NOG33927 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570891.1 Psort location: cytoplasmic, score: 23 YP_001570892.1 KEGG: eco:b4280 6.5e-128 yjhC; KpLE2 phage-like element; predicted oxidoreductase; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001570893.1 KEGG: cal:orf19.2425 2.6e-07 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001570894.1 COG: NOG15538 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570895.1 COG: COG3055 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001570896.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001570897.1 KEGG: rpr:RP465 5.4e-08 phoR; alkaline phosphatase synthesis sensor protein phoR K07636; COG: COG0591 Na+/proline symporter; Psort location: plasma membrane, score: 23 YP_001570898.1 KEGG: bte:BTH_I1550 2.1e-26 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001570899.1 KEGG: reh:H16_A0527 2.5e-41 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001570900.1 COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: cytoplasmic, score: 23 YP_001570901.1 KEGG: ehi:4.t00016 1.6e-05 dual specificity protein phosphatase, putative K04459; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001570902.1 KEGG: rpr:RP465 3.2e-07 phoR; alkaline phosphatase synthesis sensor protein phoR K07636; COG: COG0591 Na+/proline symporter; Psort location: plasma membrane, score: 23 YP_001570903.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_001570904.1 COG: COG3755 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001570905.1 KEGG: bcl:ABC2937 0.00081 NADH dehydrogenase K03885; COG: COG1309 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001570906.1 stationary phase protein that binds TrpR repressor YP_001570907.1 COG: NOG13872 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570908.1 KEGG: spt:SPA1733 5.5e-218 agp; glucose-1-phosphatase precursor (G1Pase), secreted K01085; COG: NOG06767 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001570909.1 KEGG: ava:Ava_4761 1.2e-09 THIoredoxin K03671; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: endoplasmic reticulum, score: 9 YP_001570910.1 KEGG: azo:azo0382 2.8e-05 dsbA; putative protein disulfide-isomerase K01829; COG: COG1651 Protein-disulfide isomerase; Psort location: extracellular, including cell wall, score: 9 YP_001570911.1 KEGG: xcv:XCV0567 3.2e-53 putative C-type cytochrome biogenesis protein K04084; COG: COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001570912.1 Psort location: cytoplasmic, score: 23 YP_001570913.1 COG: NOG29928 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001570914.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock YP_001570915.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA YP_001570916.1 KEGG: aha:AHA_1197 4.2e-30 ribonuclease Z, putative K00784; COG: COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III; Psort location: extracellular, including cell wall, score: 9 YP_001570917.1 KEGG: bli:BL05281 1.1e-06 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001570918.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001570919.1 Psort location: cytoplasmic, score: 23 YP_001570920.1 KEGG: sty:STY1140 4.7e-134 hpcH, hpaI; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase K02510; COG: COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Psort location: cytoplasmic, score: 23 YP_001570921.1 KEGG: sty:STY1139 2.9e-141 hpcG; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase K02509; COG: COG3971 2-keto-4-pentenoate hydratase; Psort location: cytoplasmic, score: 23 YP_001570922.1 KEGG: sec:SC1054 2.3e-61 hpaF; 4-hydroxyphenylacetate catabolism K01826; COG: COG3232 5-carboxymethyl-2-hydroxymuconate isomerase; Psort location: cytoplasmic, score: 23 YP_001570923.1 Psort location: cytoplasmic, score: 23 YP_001570924.1 KEGG: stm:STM1103 1.3e-154 hpaD; 4-hydroxyphenylacetate catabolism K00455; COG: COG3384 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570925.1 KEGG: stm:STM1102 7.4e-262 hpaE; 4-hydroxyphenylacetate catabolism K00151; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001570926.1 KEGG: stm:STM1101 9.9e-228 hpaG; putative bifunctional enzyme 2-hydroxyhepta-2,4-diene-1,7-dioatesomerase / 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioatedecarboxylase protein K05921; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001570927.1 Psort location: plasma membrane, score: 23 YP_001570928.1 COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001570929.1 KEGG: stm:STM1099 1.0e-287 hpaB; 4-hydroxyphenylacetate catabolism K00483; COG: COG2368 Aromatic ring hydroxylase; Psort location: cytoplasmic, score: 23 YP_001570930.1 KEGG: spt:SPA1752 5.8e-88 hpaC; 4-hydroxyphenylacetate 3-monooxygenase coupling protein K00484; COG: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; Psort location: cytoplasmic, score: 23 YP_001570931.1 KEGG: gbe:GbCGDNIH1_1243 2.7e-12 urate oxidase K00365; COG: COG2351 Transthyretin-like protein; Psort location: extracellular, including cell wall, score: 9 YP_001570932.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced YP_001570933.1 KEGG: sty:STY1127 5.1e-215 copS; histidine kinase K07644; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001570934.1 KEGG: lsa:LSA0897 1.2e-73 pepD5; dipeptidase D-type (U34 family) K01274; COG: COG4690 Dipeptidase; Psort location: extracellular, including cell wall, score: 9 YP_001570935.1 COG: NOG06178 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001570936.1 COG: NOG09749 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570937.1 Psort location: endoplasmic reticulum, score: 9 YP_001570938.1 COG: NOG11449 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570939.1 Psort location: nuclear, score: 23 YP_001570940.1 COG: KOG2893 Zn finger protein; Psort location: nuclear, score: 23 YP_001570941.1 Psort location: endoplasmic reticulum, score: 9 YP_001570942.1 Psort location: cytoplasmic, score: 23 YP_001570943.1 KEGG: ana:alr3268 9.2e-08 serine/threonine kinase K08884; COG: COG1357 Uncharacterized low-complexity proteins; Psort location: cytoplasmic, score: 23 YP_001570944.1 KEGG: ecc:c4301 1.6e-44 arsC; arsenate reductase K00537; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: cytoplasmic, score: 23 YP_001570945.1 KEGG: ecj:JW3469 7.3e-65 arsB; arsenite/antimonite transporter K03893; COG: COG1055 Na+/H+ antiporter NhaD and related arsenite permeases; Psort location: vesicles of secretory system, score: 9 YP_001570946.1 KEGG: ecj:JW3469 7.0e-44 arsB; arsenite/antimonite transporter K03893; COG: COG1055 Na+/H+ antiporter NhaD and related arsenite permeases; Psort location: endoplasmic reticulum, score: 9 YP_001570947.1 KEGG: cyb:CYB_1452 0.0021 NADPH-dependent FMN reductase K00299; COG: COG0431 Predicted flavoprotein; Psort location: mitochondrial, score: 23 YP_001570948.1 Psort location: cytoplasmic, score: 23 YP_001570949.1 Psort location: extracellular, including cell wall, score: 9 YP_001570950.1 COG: NOG36091 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570951.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: endoplasmic reticulum, score: 9 YP_001570952.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_001570953.1 catalyzes the hydrolysis of acylphosphate YP_001570954.1 KEGG: eci:UTI89_C1034 2.9e-196 yccW; hypothetical protein YccW K06969; COG: COG1092 Predicted SAM-dependent methyltransferases; Psort location: vesicles of secretory system, score: 9 YP_001570955.1 COG: COG3785 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001570956.1 KEGG: rru:Rru_A2075 9.5e-30 O-acetylhomoserine/O-acetylserine sulfhydrylase K01740; COG: COG1832 Predicted CoA-binding protein; Psort location: cytoplasmic, score: 23 YP_001570957.1 COG: COG3110 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001570958.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_001570959.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_001570960.1 COG: COG3304 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001570961.1 KEGG: eco:b3358 6.6e-30 yhfK; conserved inner membrane protein K01823; COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001570962.1 COG: COG3070 Regulator of competence-specific genes; Psort location: cytoplasmic, score: 23 YP_001570963.1 COG: COG5404 SOS-response cell division inhibitor, blocks FtsZ ring formation; Psort location: extracellular, including cell wall, score: 9 YP_001570964.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_001570965.1 COG: COG3120 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570966.1 KEGG: spt:SPA1782 0. lonH; Lon-like ATP-dependent protease K04770; COG: COG1067 Predicted ATP-dependent protease; Psort location: cytoplasmic, score: 23 YP_001570967.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001570968.1 COG: COG3009 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001570969.1 COG: COG3008 Paraquat-inducible protein B; Psort location: mitochondrial, score: 23 YP_001570970.1 COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: plasma membrane, score: 23 YP_001570971.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_001570972.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001570973.1 KEGG: eci:UTI89_C0875 1.8e-05 hcr; NADH oxidoreductase; COG: COG0633 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001570974.1 COG: NOG07913 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570975.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001570976.1 KEGG: stm:STM1057 0. pepN; aminopeptidase N K01256; COG: COG0308 Aminopeptidase N; Psort location: cytoplasmic, score: 23 YP_001570977.1 KEGG: sty:STY2205 6.6e-21 umuC; UmuC protein K03502; COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001570978.1 COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: cytoplasmic, score: 23 YP_001570979.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: nuclear, score: 23 YP_001570980.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001570981.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001570982.1 COG: COG3385 FOG: Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001570983.1 COG: COG3385 FOG: Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001570984.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001570985.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001570986.1 KEGG: eci:UTI89_C0999 9.6e-111 ycbL; hypothetical protein K01069; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: extracellular, including cell wall, score: 9 YP_001570987.1 COG: COG3108 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001570988.1 COG: COG2989 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001570989.1 Psort location: nuclear, score: 23 YP_001570990.1 Psort location: cytoplasmic, score: 23 YP_001570991.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001570992.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_001570993.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_001570994.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_001570995.1 COG: COG1434 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001570996.1 COG: NOG06195 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001570997.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001570998.1 KEGG: net:Neut_2110 1.2e-14 tetraacyldisaccharide 4'-kinase K00912; COG: COG2835 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001570999.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001571000.1 involved in the transport of lipid A across the inner membrane YP_001571001.1 COG: COG0658 Predicted membrane metal-binding protein; Psort location: plasma membrane, score: 23 YP_001571002.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001571003.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001571004.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001571005.1 Psort location: nuclear, score: 23 YP_001571006.1 Psort location: mitochondrial, score: 23 YP_001571007.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001571008.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001571009.1 COG: COG2323 Predicted membrane protein; Psort location: cytoplasmic, score: 23 YP_001571010.1 COG: COG1944 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571011.1 KEGG: shn:Shewana3_1556 1.9e-75 meTHIonine gamma-lyase K01761; COG: COG2116 Formate/nitrite family of transporters; Psort location: endoplasmic reticulum, score: 9 YP_001571012.1 KEGG: stm:STM0973 0. pflB; pyruvate formate lyase I K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001571013.1 COG: NOG25864 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571014.1 Psort location: cytoplasmic, score: 23 YP_001571015.1 KEGG: sec:SC0924 9.8e-102 pflA; pyruvate formate lyase activating enzyme 1 K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001571016.1 KEGG: eci:UTI89_C0120 3.7e-10 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001571017.1 KEGG: eci:UTI89_C5041 6.2e-09 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 23 YP_001571018.1 KEGG: reh:H16_A0619 2.5e-16 YcaC related amidohydrolase K00517; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001571019.1 KEGG: reh:H16_A1689 2.2e-10 ycaC; YcaC related amidohydrolase K00517; COG: COG1335 Amidases related to nicotinamidase; Psort location: cytoplasmic, score: 23 YP_001571020.1 KEGG: ecp:ECP_0910 2.4e-130 anaerobic dimethyl sulfoxide reductase, subunit C K07308; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001571021.1 KEGG: ecp:ECP_0909 3.8e-116 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001571022.1 KEGG: stm:STM0964 0. dmsA; anaerobic dimethyl sulfoxide reductase, subunit A K07306; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001571023.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001571024.1 KEGG: pha:PSHAa1714 4.9e-139 rarA; polynucleotide enzyme with nucleotide triphosphate hydrolase domain K07478; COG: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001571025.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001571026.1 KEGG: pen:PSEEN2212 6.0e-182 ftsK; cell division protein FtsK; COG: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins; Psort location: endoplasmic reticulum, score: 9 YP_001571027.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_001571028.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_001571029.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001571030.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001571031.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001571032.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001571033.1 KEGG: shn:Shewana3_3435 1.8e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571034.1 KEGG: shn:Shewana3_3385 3.6e-33 hypoxanTHIne phosphoribosyltransferase K00760; COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001571035.1 KEGG: psp:PSPPH_0909 1.1e-47 isochorismatase family protein K05993; COG: COG1335 Amidases related to nicotinamidase; Psort location: endoplasmic reticulum, score: 9 YP_001571036.1 Psort location: mitochondrial, score: 23 YP_001571037.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_001571038.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_001571039.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001571040.1 Psort location: mitochondrial, score: 23 YP_001571041.1 with MacA is involved in the export of macrolide YP_001571042.1 confers macrolide resistance via active drug efflux YP_001571043.1 COG: COG2990 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571044.1 COG: COG3593 Predicted ATP-dependent endonuclease of the OLD family; Psort location: cytoplasmic, score: 23 YP_001571045.1 COG: COG2431 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001571046.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001571047.1 KEGG: spt:SPA1863 8.0e-162 hcr; NADH oxidoreductase Hcr; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001571048.1 catalyzes the formation of acetate from pyruvate YP_001571049.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_001571050.1 KEGG: eci:UTI89_C0872 4.5e-216 ybjT; hypothetical protein YbjT K00329:K00356; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001571051.1 KEGG: eci:UTI89_C0871 1.8e-171 ybjS; hypothetical protein YbjS K00067; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001571052.1 KEGG: sty:STY0927 6.3e-146 putative N-acetylmuramoyl-L-alanine amidase K01446; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: extracellular, including cell wall, score: 9 YP_001571053.1 COG: COG0393 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001571054.1 Psort location: cytoplasmic, score: 23 YP_001571055.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001571056.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001571057.1 COG: COG0582 Integrase; Psort location: mitochondrial, score: 23 YP_001571058.1 Psort location: cytoplasmic, score: 23 YP_001571059.1 COG: NOG08103 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001571060.1 With ArtMQJI transports arginine across the inner membrane YP_001571061.1 with ArtPMJI transports arginine across the inner membrane YP_001571062.1 with ArtPQJI acts to transport arginine across the inner membrane YP_001571063.1 KEGG: eci:UTI89_C2121 9.0e-28 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001571064.1 KEGG: reh:H16_B1528 2.9e-23 sulfatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001571065.1 KEGG: stm:STM0885 6.2e-52 putative phosphotransferase enzyme II, B component K02822; COG: COG3414 Phosphotransferase system, galactitol-specific IIB component; Psort location: cytoplasmic, score: 23 YP_001571066.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001571067.1 COG: NOG35567 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571068.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_001571069.1 COG: NOG08677 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571070.1 KEGG: cyb:CYB_0398 2.8e-14 modB; molybdate ABC transporter, permease protein K02018; COG: COG1177 ABC-type spermidine/putrescine transport system, permease component II; Psort location: plasma membrane, score: 23 YP_001571071.1 KEGG: hpa:HPAG1_0451 2.0e-08 molybdenum ABC transporter ModB K06022; COG: COG1176 ABC-type spermidine/putrescine transport system, permease component I; Psort location: endoplasmic reticulum, score: 9 YP_001571072.1 part of the PotFGHI ATP-dependent putrescine transporter YP_001571073.1 COG: COG0687 Spermidine/putrescine-binding periplasmic protein; Psort location: endoplasmic reticulum, score: 9 YP_001571074.1 COG: NOG08676 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571075.1 KEGG: ava:Ava_1836 4.0e-18 glutaTHIone synthetase K01920; COG: COG0189 GlutaTHIone synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Psort location: cytoplasmic, score: 23 YP_001571076.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_001571077.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function YP_001571078.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_001571079.1 COG: NOG09759 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571080.1 COG: COG2985 Predicted permease; Psort location: plasma membrane, score: 23 YP_001571081.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571082.1 KEGG: ecp:ECP_0835 7.0e-76 putative hydrolase of the HAD superfamily K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001571083.1 KEGG: shn:Shewana3_1692 2.5e-07 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571084.1 KEGG: btk:BT9727_2194 5.0e-11 probable phosphatase, PAP2 superfamily; possible bacitracin transport permease K01112; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001571085.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001571086.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001571087.1 KEGG: eci:UTI89_C0841 1.1e-93 yliJ; hypothetical GST-like protein YliJ K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001571088.1 KEGG: azo:azo1253 1.2e-78 conserved hypothetical protein K00117; COG: COG2133 Glucose/sorbosone dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001571089.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001571090.1 Psort location: nuclear, score: 23 YP_001571091.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001571092.1 KEGG: rha:RHA1_ro09047 1.4e-07 ABC peptide transporter, permease component K02033; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001571093.1 KEGG: rha:RHA1_ro09047 5.5e-44 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001571094.1 KEGG: shn:Shewana3_2650 2.6e-34 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001571095.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_001571096.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_001571097.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001571098.1 KEGG: stm:STM0844 1.1e-162 pflE; putative pyruvate formate lyase activating enzyme K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001571099.1 KEGG: sec:SC0838 0. pflF; putative pyruvate formate lyase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001571100.1 KEGG: stm:STM0842 7.7e-141 ybiV(1); putative hydrolase of the HAD superfamily K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001571101.1 COG: NOG06762 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571102.1 COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001571103.1 KEGG: dre:30298 0.0026 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571104.1 KEGG: ssn:SSO_0800 0. putative glucosidase K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001571105.1 KEGG: eci:UTI89_C0824 1.3e-273 ybiT; hypothetical ABC transporter ATP-binding protein YbiT K01957; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: cytoskeletal, score: 9 YP_001571106.1 KEGG: eci:UTI89_C2228 2.8e-104 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001571107.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001571108.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_001571109.1 Psort location: extracellular, including cell wall, score: 9 YP_001571110.1 Psort location: mitochondrial, score: 23 YP_001571111.1 KEGG: eci:UTI89_C0819 5.9e-237 ybiP; hypothetical protein YbiP K00924; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: plasma membrane, score: 23 YP_001571112.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_001571113.1 KEGG: pae:PA1977 2.2e-07 sensor protein GLPS; COG: COG5006 Predicted permease, DMT superfamily; Psort location: plasma membrane, score: 23 YP_001571114.1 Psort location: cytoplasmic, score: 23 YP_001571115.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_001571116.1 similar to periplasmic-binding component of ABC transporters YP_001571117.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_001571118.1 similar to ATP-binding component of ABC transporters YP_001571119.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001571120.1 KEGG: vfi:VFA1153 4.2e-78 methyltransferase; COG: COG3129 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001571121.1 KEGG: sme:SMc00768 0.0059 aceA; isocitrate lyase K01637; COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001571122.1 COG: NOG13870 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571123.1 KEGG: rso:RSc0378 2.6e-53 trpD3, RS03346; putative anthranilate phosphoribosyltransferase protein K00766; COG: COG0547 Anthranilate phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001571124.1 helicase involved in DNA repair and perhaps also replication YP_001571125.1 Psort location: cytoplasmic, score: 23 YP_001571126.1 this helicase is not essential cell growth YP_001571127.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571128.1 COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001571129.1 KEGG: rru:Rru_A1792 5.3e-165 ABC transporter component K01990; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001571130.1 KEGG: fal:FRAAL1796 1.9e-11 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001571131.1 KEGG: fal:FRAAL1796 5.3e-09 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001571132.1 COG: NOG09757 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001571133.1 Psort location: cytoplasmic, score: 23 YP_001571134.1 KEGG: eci:UTI89_C0791 7.3e-42 ybhP; putative DNase; COG: COG3568 Metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001571135.1 KEGG: stt:t2076 1.9e-224 ybhO; putative phospholipase K06132; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: cytoplasmic, score: 23 YP_001571136.1 COG: COG0392 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001571137.1 KEGG: cch:Cag_0640 0.0096 NADH dehydrogenase I subunit 6 K00339; COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: endoplasmic reticulum, score: 9 YP_001571138.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001571139.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001571140.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001571141.1 KEGG: mtu:Rv0984 1.9e-11 moaB2; possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-A-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD); COG: COG0521 Molybdopterin biosynthesis enzymes; Psort location: cytoplasmic, score: 23 YP_001571142.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001571143.1 KEGG: mth:MTH1018 0.00046 LPPG:FO 2-phopspho-L-lactate transferase K00924; COG: COG0391 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001571144.1 KEGG: cal:orf19.5148 4.7e-11 CDC35; adenylate cyclase K01768; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001571145.1 Psort location: cytoplasmic, score: 23 YP_001571146.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001571147.1 Psort location: mitochondrial, score: 23 YP_001571148.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001571149.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_001571150.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_001571151.1 KEGG: spt:SPA1958 1.9e-183 bioB; biotin synthetase K01012; COG: COG0502 Biotin synthase and related enzymes; Psort location: nuclear, score: 23 YP_001571152.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001571153.1 YbhB; similar to rat and human kinase inhibitory proteins YP_001571154.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001571155.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001571156.1 KEGG: reh:H16_A3019 1.6e-53 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001571157.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_001571158.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001571159.1 Psort location: nuclear, score: 23 YP_001571160.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_001571161.1 COG: NOG10127 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001571162.1 COG: COG1020 Non-ribosomal peptide synthetase modules and related proteins; Psort location: cytoplasmic, score: 23 YP_001571163.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: nuclear, score: 23 YP_001571164.1 Psort location: vesicles of secretory system, score: 9 YP_001571165.1 KEGG: rha:RHA1_ro08393 0.0066 transposase; COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001571166.1 Psort location: cytoplasmic, score: 23 YP_001571167.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001571168.1 COG: COG3547 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001571169.1 Psort location: cytoplasmic, score: 23 YP_001571170.1 KEGG: tpe:Tpen_1086 0.0079 proton-translocating NADH-quinone oxidoreductase, chain M; COG: NOG06795 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001571171.1 KEGG: ecc:c3627 1.1e-283 iucA; iucA protein K03894; COG: COG4264 Siderophore synthetase component; Psort location: mitochondrial, score: 23 YP_001571172.1 KEGG: sfl:SF3716 4.7e-157 iucB; IucB K03896; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001571173.1 KEGG: ecc:c3625 1.1e-294 iucC; iucC protein K03895; COG: COG4264 Siderophore synthetase component; Psort location: cytoplasmic, score: 23 YP_001571174.1 KEGG: ssn:SSO_3604 2.4e-201 iucD; lysine:N6-hydroxylase K03897; COG: COG3486 Lysine/orniTHIne N-monooxygenase; Psort location: cytoplasmic, score: 23 YP_001571175.1 KEGG: shn:Shewana3_3063 0.0063 phosphatidylglycerophosphatase K01094; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: cytoplasmic, score: 23 YP_001571176.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_001571177.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_001571178.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_001571179.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_001571180.1 with ModCB is involved in the high-affinity transport of molybdate YP_001571181.1 COG: NOG17580 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001571182.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_001571183.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_001571184.1 Psort location: cytoplasmic, score: 23 YP_001571185.1 KEGG: sec:SC0774 5.6e-99 galE; UDP-galactose 4-epimerase K01784; COG: COG1087 UDP-glucose 4-epimerase; Psort location: cytoplasmic, score: 23 YP_001571186.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_001571187.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001571188.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_001571189.1 KEGG: eci:UTI89_C1926 6.9e-69 ydjC; hypothetical protein YdjC K03478; COG: COG3394 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571190.1 KEGG: ssn:SSO_1424 1.7e-191 celF; cryptic phospho-beta-glucosidase K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001571191.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_001571192.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001571193.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001571194.1 Psort location: nuclear, score: 23 YP_001571195.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001571196.1 KEGG: pfa:PF08_0034 0.00065 gcn5; histone acetyltransferase Gcn5, putative K00653; COG: NOG09755 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571197.1 involved in zinc efflux across the cytoplasmic membrane YP_001571198.1 COG: COG3201 Nicotinamide mononucleotide transporter; Psort location: plasma membrane, score: 23 YP_001571199.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001571200.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_001571201.1 KEGG: bxe:Bxe_A4171 1.5e-07 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: nuclear, score: 23 YP_001571202.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001571203.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_001571204.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001571205.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001571206.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_001571207.1 COG: COG3790 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001571208.1 COG: COG4890 Predicted outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001571209.1 KEGG: spt:SPA2002 3.2e-206 cydB; cytochrome d ubiquinol oxidase subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001571210.1 KEGG: stm:STM0740 2.2e-278 cydA; cytochrome d terminal oxidase, polypeptide subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001571211.1 Psort location: cytoplasmic, score: 23 YP_001571212.1 converts methylaspartate to L-glutamate YP_001571213.1 KEGG: fnu:FN1854 1.7e-58 methylaspartate mutase K01846; COG: NOG07779 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571214.1 KEGG: tde:TDE2236 2.0e-149 glmE; methylaspartate mutase, E subunit K01846; COG: COG4865 Glutamate mutase epsilon subunit; Psort location: cytoplasmic, score: 23 YP_001571215.1 KEGG: ece:Z0892 3.0e-210 putative methylaspartate ammonia-lyase K04835; COG: COG3799 Methylaspartate ammonia-lyase; Psort location: cytoplasmic, score: 23 YP_001571216.1 COG: NOG07992 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571217.1 COG: NOG19635 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571218.1 KEGG: eci:UTI89_C4668 6.9e-69 gltP; glutamate-aspartate symport protein K03309; COG: COG1301 Na+/H+-dicarboxylate symporters; Psort location: plasma membrane, score: 23 YP_001571219.1 KEGG: ece:Z0887 1.5e-256 putative fumarate hydratase K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001571220.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001571221.1 KEGG: shn:Shewana3_3435 0.0021 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571222.1 KEGG: bli:BL05281 2.5e-07 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001571223.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001571224.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001571225.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001571226.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001571227.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001571228.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001571229.1 KEGG: sty:STY0776 6.7e-55 sdhD; succinate dehydrogenase hydrophobic membrane anchor protein K00242; COG: COG2142 Succinate dehydrogenase, hydrophobic anchor subunit; Psort location: endoplasmic reticulum, score: 9 YP_001571230.1 KEGG: spt:SPA2011 7.6e-63 sdhC; succinate dehydrogenase cytochrome b-556 subunit K00241; COG: COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001571231.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001571232.1 COG: COG3180 Putative ammonia monooxygenase; Psort location: endoplasmic reticulum, score: 23 YP_001571233.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_001571234.1 Psort location: cytoskeletal, score: 9 YP_001571235.1 Psort location: cytoplasmic, score: 23 YP_001571236.1 COG: COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; Psort location: cytoplasmic, score: 23 YP_001571237.1 KEGG: eci:UTI89_C0710 2.0e-142 ybgK; hypothetical protein K01941; COG: COG1984 Allophanate hydrolase subunit 2; Psort location: cytoplasmic, score: 23 YP_001571238.1 KEGG: eci:UTI89_C0709 6.0e-102 ybgJ; hypothetical protein YbgJ K01457; COG: COG2049 Allophanate hydrolase subunit 1; Psort location: cytoplasmic, score: 23 YP_001571239.1 COG: COG0327 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571240.1 KEGG: ace:Acel_1973 0.0034 V-type H(+)-translocating pyrophosphatase K01507; COG: COG3104 Dipeptide/tripeptide permease; Psort location: plasma membrane, score: 23 YP_001571241.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_001571242.1 COG: NOG36642 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571243.1 COG: NOG36642 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571244.1 COG: NOG14030 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571245.1 KEGG: eci:UTI89_C0121 0.00094 usp; uropathogenic specific protein K01150; COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001571246.1 Psort location: cytoplasmic, score: 23 YP_001571247.1 Psort location: mitochondrial, score: 23 YP_001571248.1 COG: NOG13868 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571249.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001571250.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001571251.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_001571252.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_001571253.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport YP_001571254.1 KEGG: stm:STM0701 0. speF; orniTHIne decarboxylase isozyme K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001571255.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_001571256.1 COG: COG3467 Predicted flavin-nucleotide-binding protein; Psort location: cytoplasmic, score: 23 YP_001571257.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001571258.1 negative modulator of the initiation of chromosome replication YP_001571259.1 Psort location: cytoplasmic, score: 23 YP_001571260.1 KEGG: stm:STM0696 2.0e-101 ybfF; putative enzyme; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001571261.1 COG: NOG13544 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571262.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001571263.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_001571264.1 KEGG: afu:AF0661 0.00018 heterodisulfide reductase, subunit E, putative K03390; COG: NOG06514 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571265.1 KEGG: cal:orf19.4384 0.00011 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571266.1 COG: NOG11319 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571267.1 KEGG: psp:PSPPH_3782 3.2e-12 porin D; COG: NOG06287 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001571268.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001571269.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001571270.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_001571271.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_001571272.1 KEGG: eci:UTI89_C0670 4.0e-199 nagC; transcriptional repressor of nag (N-acetylglucosamine) operon K02565; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001571273.1 KEGG: eci:UTI89_C0669 1.3e-129 nagD; N-acetylglucosamine metabolism K02566; COG: COG0647 Predicted sugar phosphatases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001571274.1 Psort location: endoplasmic reticulum, score: 9 YP_001571275.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_001571277.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_001571278.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001571279.1 KEGG: reh:H16_A0527 9.8e-86 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001571280.1 KEGG: dps:DP1605 3.4e-09 probable pyridoxal phosphate biosynthetic protein K03474; COG: COG0319 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001571281.1 KEGG: eci:UTI89_C0656 1.1e-148 ybeX; putative transport protein K06189; COG: COG4535 Putative Mg2+ and Co2+ transporter CorC; Psort location: cytoplasmic, score: 23 YP_001571282.1 Transfers the fatty acyl group on membrane lipoproteins YP_001571283.1 KEGG: bur:Bcep18194_A4762 7.7e-22 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001571284.1 KEGG: eca:ECA0855 3.0e-20 ABC transporter permease protein K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001571285.1 KEGG: ret:RHE_PF00254 1.5e-26 glnP, glnQ; glutamine ABC transporter, ATP-binding protein K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001571286.1 KEGG: stt:t2211 3.8e-123 gltL; glutamate/aspartate transport ATP-binding protein GltL K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001571287.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_001571288.1 COG: NOG08739 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571289.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001571290.1 COG: COG2980 Rare lipoprotein B; Psort location: nuclear, score: 23 YP_001571291.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001571292.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001571293.1 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase YP_001571294.1 KEGG: sec:SC0673 7.0e-108 cobC; alpha ribazole-5'-P phosphatase in cobalamin synthesis K02226; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: mitochondrial, score: 23 YP_001571295.1 KEGG: bba:Bd3846 5.6e-10 probable nicotinate-nucleotide adenylyltransferase K00969; COG: COG0799 Uncharacterized homolog of plant Iojap protein; Psort location: cytoplasmic, score: 23 YP_001571296.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001571297.1 KEGG: eci:UTI89_C0637 0. mrdA; cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 K05515; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: cytoplasmic, score: 23 YP_001571298.1 COG: COG0772 Bacterial cell division membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001571299.1 KEGG: pfo:Pfl_1900 0.00030 argininosuccinate synthase K03749; COG: COG0797 Lipoproteins; Psort location: nuclear, score: 23 YP_001571300.1 Psort location: mitochondrial, score: 23 YP_001571301.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_001571302.1 KEGG: dme:Dmel_CG10495 0.0086 CG10495 K05545; COG: COG2921 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571303.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001571304.1 COG: COG0583 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001571305.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001571306.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001571307.1 KEGG: eci:UTI89_C0629 1.2e-98 ybeM; putative amidase K01501; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001571308.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_001571309.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_001571310.1 catalyzes the transfer of palmitate to lipid A YP_001571311.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_001571312.1 regulates the expression of citAB in citrate fermentation YP_001571313.1 KEGG: stt:t2242 1.1e-283 dpiB; sensor kinase DpiB K07700; COG: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001571314.1 Psort location: nuclear, score: 23 YP_001571315.1 Psort location: endoplasmic reticulum, score: 9 YP_001571316.1 KEGG: stm:STM0624 2.0e-188 citC; citrate lyase synthetase K01910; COG: COG3053 Citrate lyase synthetase; Psort location: cytoplasmic, score: 23 YP_001571317.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001571318.1 KEGG: stm:STM0622 1.7e-152 citE; citrate lyase beta chain (acyl lyase subunit) K01660:K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: mitochondrial, score: 23 YP_001571319.1 KEGG: stm:STM0621 5.6e-257 citF; bifunctional citrate lyase alpha chain/citrate-ACP transferase K01037:K01643; COG: COG3051 Citrate lyase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001571320.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_001571321.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA YP_001571322.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001571323.1 KEGG: stt:t2250 1.2e-133 rna; ribonuclease I precursor K01169; COG: COG3719 Ribonuclease I; Psort location: extracellular, including cell wall, score: 9 YP_001571324.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001571325.1 KEGG: psp:PSPPH_3469 2.2e-134 fdh; glutaTHIone-dependent formaldehyde dehydrogenase; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001571326.1 Psort location: cytoplasmic, score: 23 YP_001571327.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001571328.1 KEGG: dsy:DSY0599 3.6e-17 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001571329.1 KEGG: dsy:DSY0598 3.7e-47 dmsB; putative anaerobic DMSO reductase chain B iron-sulfur subunit K00369; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001571330.1 KEGG: dsy:DSY0597 3.5e-184 dmsA; putative anaerobic DMSO reductase chain A precursor K00369; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001571331.1 KEGG: vfi:VFA0083 3.4e-12 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001571332.1 KEGG: stm:STM0609 2.5e-270 ahpF; alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides K03387; COG: COG3634 Alkyl hydroperoxide reductase, large subunit; Psort location: cytoplasmic, score: 23 YP_001571333.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_001571334.1 Involved in disulfide bond formation YP_001571335.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571336.1 KEGG: eci:UTI89_C2238 1.4e-143 ibrA; hypothetical protein YbdN K00390; COG: COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase; Psort location: cytoplasmic, score: 23 YP_001571337.1 COG: COG1475 Predicted transcriptional regulators; Psort location: cytoskeletal, score: 9 YP_001571338.1 catalyzes the transfer of an amino moiety YP_001571339.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_001571340.1 COG: COG2879 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001571341.1 KEGG: xtr:3283503 0.0032 ND6; NADH dehydrogenase subunit 6 K03884; COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001571342.1 KEGG: eco:b0597 9.1e-67 ybdB; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001571343.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_001571344.1 KEGG: spt:SPA2137 5.9e-150 entB; isochorismatase K01252; COG: COG3433 Aryl carrier domain; Psort location: cytoplasmic, score: 23 YP_001571345.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_001571346.1 KEGG: stm:STM0595 1.8e-203 entC; isochorismate synthetase, enterochelin biosynthesis K02361; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001571347.1 with FepCDG is involved in the transport of ferric enterobactin YP_001571348.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_001571349.1 with FepBCG is involved in the transport of ferric enterobactin YP_001571350.1 with FepBCD is involved in the transport of ferric enterobactin YP_001571351.1 with FepBDE is involved in the transport of ferric enterobactin YP_001571352.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_001571353.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_001571354.1 COG: COG3251 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571355.1 KEGG: btk:BT9727_2470 2.4e-12 probable esterase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001571356.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001571357.1 KEGG: sec:SC0615 1.1e-93 entD; enterochelin synthetase, component D (phoshpantetheinyltransferase) K02362; COG: COG2977 Phosphopantetheinyl transferase component of siderophore synthetase; Psort location: cytoplasmic, score: 23 YP_001571358.1 Psort location: cytoplasmic, score: 23 YP_001571359.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_001571360.1 COG: NOG15356 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571361.1 KEGG: bcz:BCZK3497 4.0e-09 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001571362.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571363.1 COG: COG2315 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571364.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_001571365.1 KEGG: stm:STM0577 2.5e-71 putative PTS system, mannose-specific II component K02793; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: endoplasmic reticulum, score: 23 YP_001571366.1 KEGG: stm:STM0576 3.9e-75 putative PTS system, mannose-specific II component K02794; COG: COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; Psort location: extracellular, including cell wall, score: 9 YP_001571367.1 KEGG: eci:UTI89_C2015 1.3e-35 manY; PTS enzyme IIC, mannose-specific K02795; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001571368.1 KEGG: hso:HS_0607 1.4e-52 manZ; protein-N(pi)-phosphohistidine-sugar phosphotransferase (mannose-specific phosphotransferase system IID component) K02796; COG: COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; Psort location: vacuolar, score: 9 YP_001571369.1 KEGG: lwe:lwe2019 1.3e-28 glucosamine--fructose-6-phosphate aminotransferase , putative K00820; COG: COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; Psort location: cytoplasmic, score: 23 YP_001571370.1 KEGG: eco:b3371 2.7e-26 frlB, yhfN; fructoselysine-6-P-deglycase; COG: COG2222 Predicted phosphosugar isomerases; Psort location: cytoplasmic, score: 23 YP_001571371.1 KEGG: reh:H16_A0728 3.2e-18 response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K01529; COG: COG3933 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001571372.1 KEGG: pen:PSEEN0445 2.4e-24 estA; esterase EstA precursor K01044; COG: COG3240 Phospholipase/leciTHInase/hemolysin; Psort location: endoplasmic reticulum, score: 9 YP_001571373.1 Psort location: cytoplasmic, score: 23 YP_001571374.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001571375.1 KEGG: eci:UTI89_C0120 3.7e-157 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001571376.1 KEGG: dre:562769 9.7e-06 LOC562769; similar to Serine/threonine-protein kinase 10 (Lymphocyte-oriented kinase) K08837; COG: COG1076 DnaJ-domain-containing proteins 1; Psort location: nuclear, score: 23 YP_001571377.1 COG: COG3059 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001571378.1 COG: NOG18530 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571379.1 Psort location: cytoplasmic, score: 23 YP_001571380.1 Involved in disulfide oxidoreductase activity and electron transport YP_001571381.1 KEGG: bur:Bcep18194_C7173 2.4e-06 two component transcriptional regulator, AraC family; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001571382.1 COG: COG3696 Putative silver efflux pump; Psort location: cytoplasmic, score: 23 YP_001571383.1 COG: NOG25544 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571384.1 KEGG: rpa:RPA2162 4.7e-11 possible serine protease/outer membrane autotransporter K01423; COG: COG4625 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain; Psort location: extracellular, including cell wall, score: 9 YP_001571385.1 KEGG: ypn:YPN_3027 0. chondroitin-sulfate-ABC endolyase / chondroitin-sulfate-ABC exolyase K08961:K08962; COG: NOG36889 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571386.1 COG: COG3335 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001571387.1 COG: NOG09015 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571388.1 Psort location: cytoplasmic, score: 23 YP_001571389.1 Psort location: endoplasmic reticulum, score: 9 YP_001571390.1 Psort location: nuclear, score: 23 YP_001571391.1 COG: NOG09971 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571392.1 COG: NOG18514 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571393.1 COG: COG3926 Putative secretion activating protein; Psort location: extracellular, including cell wall, score: 9 YP_001571394.1 KEGG: sty:STY1890 3.0e-100 putative pertussis-like toxin subunit; COG: NOG18513 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571395.1 COG: NOG27732 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571396.1 Psort location: cytoplasmic, score: 23 YP_001571397.1 COG: COG3436 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001571398.1 COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001571399.1 COG: NOG24177 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571400.1 COG: NOG13881 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571401.1 COG: COG4733 Phage-related protein, tail component; Psort location: nuclear, score: 23 YP_001571402.1 COG: NOG34132 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571403.1 Psort location: cytoplasmic, score: 23 YP_001571404.1 Psort location: mitochondrial, score: 23 YP_001571405.1 Psort location: cytoplasmic, score: 23 YP_001571406.1 KEGG: sec:SC2613 2.1e-42 enpP; hypothetical protein K01423; COG: NOG10270 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001571407.1 KEGG: eci:UTI89_C2514 5.6e-54 yfaL; hypothetical protein YfaL precursor K07279; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: extracellular, including cell wall, score: 9 YP_001571408.1 Psort location: extracellular, including cell wall, score: 9 YP_001571409.1 KEGG: cvi:CV0024 5.4e-06 probable hydroxyethylTHIazole kinase K00878; COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001571410.1 COG: COG3311 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001571411.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: mitochondrial, score: 23 YP_001571412.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001571413.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001571414.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001571415.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001571416.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001571417.1 COG: COG2501 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571418.1 Psort location: cytoplasmic, score: 23 YP_001571419.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001571420.1 Psort location: cytoplasmic, score: 23 YP_001571421.1 KEGG: sty:STY0584 8.5e-87 ppiB; peptidyl-prolyl cis-trans isomerase B K03768; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: cytoplasmic, score: 23 YP_001571422.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001571423.1 KEGG: stm:STM0534 4.2e-85 purE; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit K01588; COG: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Psort location: cytoplasmic, score: 23 YP_001571424.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001571425.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_001571426.1 KEGG: baa:BA_0884 2.9e-47 binding-protein-dependent transport systems inner membrane component K00294; COG: COG2011 ABC-type metal ion transport system, permease component; Psort location: plasma membrane, score: 23 YP_001571427.1 KEGG: rru:Rru_A0788 5.9e-79 ABC transporter component K06020; COG: COG1135 ABC-type metal ion transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001571428.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001571429.1 COG: COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001571430.1 KEGG: pen:PSEEN1885 1.6e-60 ABC transporter, ATP-binding protein; COG: COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component; Psort location: cytoplasmic, score: 23 YP_001571431.1 KEGG: spt:SPA2216 2.5e-96 tesA; acyl-coA THIoesterase I K01076; COG: COG2755 Lysophospholipase L1 and related esterases; Psort location: extracellular, including cell wall, score: 9 YP_001571432.1 KEGG: sty:STY0551 3.4e-131 ybbO; hypothetical oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001571433.1 KEGG: eci:UTI89_C0527 4.3e-140 ybbN; putative THIoredoxin-like protein K05838; COG: COG3118 Thioredoxin domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001571434.1 COG: COG0390 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001571435.1 KEGG: psb:Psyr_0081 1.2e-27 ABC transporter K02045; COG: COG4619 ABC-type uncharacterized transport system, ATPase component; Psort location: mitochondrial, score: 23 YP_001571436.1 KEGG: reh:H16_A2036 4.4e-58 membrane protease subunits, stomatin/prohibitin homologs K01423; COG: COG0330 Membrane protease subunits, stomatin/prohibitin homologs; Psort location: cytoplasmic, score: 23 YP_001571437.1 COG: COG1585 Membrane protein implicated in regulation of membrane protease activity; Psort location: cytoplasmic, score: 23 YP_001571438.1 activator of copper-responsive regulon genes YP_001571439.1 KEGG: sty:STY0544 0. ybaR; copper-transporting ATPase K01533; COG: COG2217 Cation transport ATPase; Psort location: endoplasmic reticulum, score: 9 YP_001571440.1 COG: COG3735 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571441.1 KEGG: gme:Gmet_1354 0.0027 prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571442.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_001571443.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571444.1 Psort location: cytoplasmic, score: 23 YP_001571445.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_001571446.1 KEGG: stm:STM0491 6.8e-236 gsk; inosine-guanosine kinase K00892; COG: COG0524 Sugar kinases, ribokinase family; Psort location: mitochondrial, score: 23 YP_001571447.1 KEGG: spt:SPA2232 9.4e-168 aes; acetyl esterase K01066; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001571448.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001571449.2 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001571450.1 molecular chaperone YP_001571451.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001571452.1 COG: COG0718 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571453.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001571454.1 COG: COG2832 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001571455.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks YP_001571456.1 COG: NOG18531 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571457.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001571458.1 Psort location: nuclear, score: 23 YP_001571459.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_001571460.1 KEGG: saz:Sama_0326 0.0047 phosphopantothenoylcysteine decarboxylase, phosphopantothenate--cysteine ligase K01598:K01922; COG: COG0845 Membrane-fusion protein; Psort location: extracellular, including cell wall, score: 9 YP_001571461.1 KEGG: eci:UTI89_C2351 2.1e-108 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001571462.1 COG: NOG09846 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571463.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_001571464.1 KEGG: stm:STM0472 2.9e-93 maa; maltose o-acetyltransferase K00661; COG: COG0110 Acetyltransferase (isoleucine patch superfamily); Psort location: cytoplasmic, score: 23 YP_001571465.1 COG: NOG07873 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571466.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001571467.1 KEGG: mca:MCA1246 9.3e-33 methyltransferase CheR, putative K03412:K00575; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001571468.1 KEGG: eci:UTI89_C0482 3.3e-46 ybaZ; hypothetical protein YbaZ K07443; COG: COG3695 Predicted methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001571469.1 COG: COG3126 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001571470.1 KEGG: sec:SC0507 3.5e-152 tesB; acyl-CoA THIoesterase II K01076; COG: COG1946 Acyl-CoA THIoesterase; Psort location: cytoplasmic, score: 23 YP_001571471.1 KEGG: ter:Tery_3993 1.1e-35 adenylate/guanylate cyclase K01769; COG: COG0004 Ammonia permease; Psort location: plasma membrane, score: 23 YP_001571472.1 Psort location: mitochondrial, score: 23 YP_001571473.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_001571474.1 KEGG: cch:Cag_0453 5.2e-71 ATPase K06147; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001571475.1 KEGG: reh:H16_A0776 5.9e-79 ABC-type transporter, ATPase and permease components: Prot2E family; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001571476.1 COG: COG1522 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001571477.1 KEGG: sec:SC0500 1.1e-187 putative cysteine synthase/cystaTHIonine beta-synthase K01738; COG: COG0031 Cysteine synthase; Psort location: cytoplasmic, score: 23 YP_001571478.1 KEGG: aha:AHA_0482 3.3e-21 phosphatase YidA K01112; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001571479.1 COG: COG4533 ABC-type uncharacterized transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001571480.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_001571481.1 KEGG: gbe:GbCGDNIH1_1102 1.0e-10 short-chain acyl-CoA hydrolase; COG: COG0824 Predicted THIoesterase; Psort location: cytoplasmic, score: 23 YP_001571482.1 KEGG: bur:Bcep18194_A5099 0.00031 RNA binding S1; COG: COG1555 DNA uptake protein and related DNA-binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001571483.1 KEGG: stm:STM0452 0. cypD; peptidyl prolyl isomerase K03770; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: endoplasmic reticulum, score: 9 YP_001571484.1 histone-like DNA-binding protein YP_001571485.1 KEGG: stm:STM0450 0. lon; ATP-dependent protease Lon K01338; COG: COG0466 ATP-dependent Lon protease, bacterial type; Psort location: cytoplasmic, score: 23 YP_001571486.1 binds and unfolds substrates as part of the ClpXP protease YP_001571487.1 KEGG: sec:SC0490 1.1e-125 clpP; proteolytic subunit of ClpA-ClpP ATP-dependent serine protease, heat shock protein F215 K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: cytoplasmic, score: 23 YP_001571488.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001571489.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_001571490.1 COG: COG3056 Uncharacterized lipoprotein; Psort location: cytoplasmic, score: 23 YP_001571491.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_001571492.1 KEGG: sec:SC0485 1.0e-168 cyoA; cytochrome o ubiquinol oxidase subunit II K02297; COG: COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2; Psort location: endoplasmic reticulum, score: 9 YP_001571493.1 KEGG: stt:t2418 0. cyoB; cytochrome o ubiquinol oxidase subunit I K02298; COG: COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; Psort location: plasma membrane, score: 23 YP_001571494.1 KEGG: sty:STY0483 1.9e-107 cyoC; cytochrome o ubiquinol oxidase subunit III K02299; COG: COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3; Psort location: endoplasmic reticulum, score: 9 YP_001571495.1 KEGG: eci:UTI89_C0452 3.0e-52 cyoD; cytochrome o ubiquinol oxidase protein CyoD K02300; COG: COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4; Psort location: endoplasmic reticulum, score: 9 YP_001571496.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001571497.1 Psort location: cytoskeletal, score: 9 YP_001571498.1 Psort location: cytoplasmic, score: 23 YP_001571499.1 KEGG: shn:Shewana3_1692 5.1e-07 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571500.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001571501.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001571502.1 KEGG: eci:UTI89_C0447 2.6e-94 THIJ; 4-methyl-5(B-hydroxyethyl)-THIazole monophosphate biosynthesis enzyme K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: endoplasmic reticulum, score: 9 YP_001571503.1 Required for the synthesis of the thiazole moiety YP_001571504.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001571505.1 KEGG: spt:SPA2300 5.9e-150 ispA; geranyltranstransferase K00795; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: cytoplasmic, score: 23 YP_001571506.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001571507.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate YP_001571508.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001571509.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001571510.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001571511.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_001571512.1 KEGG: eci:UTI89_C0435 1.6e-46 ybaD; hypothetical protein K07738; COG: COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Psort location: mitochondrial, score: 23 YP_001571513.1 COG: NOG07872 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571514.1 Psort location: nuclear, score: 23 YP_001571515.1 Psort location: endoplasmic reticulum, score: 9 YP_001571516.1 COG: COG3248 Nucleoside-binding outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001571517.1 COG: NOG13275 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001571518.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001571519.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001571520.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001571521.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001571522.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001571523.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_001571524.1 KEGG: stm:STM0402 1.7e-106 putative THIol - alkyl hydroperoxide reductase K03386; COG: COG0450 Peroxiredoxin; Psort location: cytoplasmic, score: 23 YP_001571525.1 KEGG: sty:STY0439 0. malZ; maltodextrin glucosidase K01187; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001571526.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_001571527.1 KEGG: bja:bll5026 0.0062 rrpP; H+ translocating pyrophosphate synthase K01507; COG: COG1114 Branched-chain amino acid permeases; Psort location: plasma membrane, score: 23 YP_001571528.1 Psort location: nuclear, score: 23 YP_001571529.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_001571530.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_001571531.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_001571532.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_001571533.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers YP_001571534.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_001571535.1 Required for efficient pilin antigenic variation YP_001571536.1 COG: COG3123 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571537.1 COG: NOG06193 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571538.1 COG: NOG13867 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571539.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001571540.1 COG: COG1671 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571541.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001571542.1 COG: NOG17162 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571543.1 COG: NOG14126 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571544.1 KEGG: bma:BMAA1647 1.6e-05 diaminobutyrate--pyruvate aminotransferase/membrane protein, putative K00836; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001571545.1 COG: COG3921 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001571546.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001571547.1 COG: NOG15537 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571548.1 COG: NOG11448 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571549.1 COG: NOG06003 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571550.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_001571551.1 this protein has no known enzymatic function YP_001571552.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001571553.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent YP_001571554.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_001571555.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_001571556.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_001571557.1 KEGG: reh:H16_A1904 1.5e-82 prpR; propionate catabolism activator K01529; COG: COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001571558.1 COG: NOG14127 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571559.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001571560.1 Psort location: endoplasmic reticulum, score: 9 YP_001571561.1 KEGG: stm:STM0361 3.9e-178 cytochrome BD2 subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001571562.1 KEGG: stm:STM0360 1.1e-251 cytochrome BD2 subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001571563.1 KEGG: spt:SPA2365 0. res; DNA restriction (DNA helicase K01156; COG: COG3587 Restriction endonuclease; Psort location: cytoplasmic, score: 23 YP_001571564.1 KEGG: sty:STY0388 0. mod; type III restriction-modification system StyLTI enzyme mod K07316; COG: COG2189 Adenine specific DNA methylase Mod; Psort location: cytoplasmic, score: 23 YP_001571565.1 KEGG: cal:orf19.3668 1.4e-07 HGT2; hexose transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571566.1 Psort location: cytoplasmic, score: 23 YP_001571567.1 COG: COG2608 Copper chaperone; Psort location: cytoplasmic, score: 23 YP_001571568.1 COG: NOG27432 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571569.1 KEGG: shn:Shewana3_3435 3.1e-18 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571570.1 KEGG: sec:SC0852 3.3e-291 etfD; putative dehydrogenase (flavoproteins) K00311; COG: COG0644 Dehydrogenases (flavoproteins); Psort location: cytoplasmic, score: 23 YP_001571571.1 KEGG: fra:Francci3_2429 1.2e-10 L-carnitine dehydratase/bile acid-inducible protein F K07749; COG: COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Psort location: cytoplasmic, score: 23 YP_001571572.1 KEGG: stm:STM0857 4.8e-203 putative acyl-CoA dehydrogenase K00249; COG: COG1960 Acyl-CoA dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001571573.1 COG: COG3777 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571574.1 KEGG: fnu:FN1424 3.3e-23 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001571575.1 COG: COG2086 Electron transfer flavoprotein, beta subunit; Psort location: cytoplasmic, score: 23 YP_001571576.1 Psort location: cytoplasmic, score: 23 YP_001571577.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001571578.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001571579.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571580.1 COG: NOG17103 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571581.1 Psort location: cytoplasmic, score: 23 YP_001571582.1 Psort location: cytoplasmic, score: 23 YP_001571583.1 COG: NOG06535 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571584.1 COG: NOG17103 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571585.1 COG: NOG17103 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571586.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571587.1 Psort location: mitochondrial, score: 23 YP_001571588.1 Psort location: cytoplasmic, score: 23 YP_001571589.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571590.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001571591.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571592.1 Psort location: endoplasmic reticulum, score: 9 YP_001571593.1 Psort location: cytoskeletal, score: 9 YP_001571594.1 Psort location: cytoplasmic, score: 23 YP_001571595.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001571596.1 Psort location: endoplasmic reticulum, score: 9 YP_001571597.1 KEGG: cvi:CV0024 2.7e-67 probable hydroxyethylTHIazole kinase K00878; COG: NOG11775 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571598.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571599.1 COG: COG3521 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571600.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571601.1 COG: NOG17103 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571602.1 KEGG: eci:UTI89_C0121 1.5e-151 usp; uropathogenic specific protein K01150; COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571603.1 COG: COG3521 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001571604.1 COG: COG3520 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571605.1 COG: COG3519 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571606.1 COG: COG3515 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571607.1 Psort location: cytoplasmic, score: 23 YP_001571608.1 Psort location: cytoplasmic, score: 23 YP_001571609.1 KEGG: eci:UTI89_C0725 3.3e-94 hypothetical protein K00754; COG: NOG18138 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571610.1 Psort location: cytoplasmic, score: 23 YP_001571611.1 COG: COG3523 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001571612.1 COG: NOG35365 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571613.1 Psort location: cytoplasmic, score: 23 YP_001571614.1 Psort location: nuclear, score: 23 YP_001571615.1 Psort location: extracellular, including cell wall, score: 9 YP_001571616.1 Psort location: cytoplasmic, score: 23 YP_001571617.1 Psort location: cytoplasmic, score: 23 YP_001571618.1 Psort location: extracellular, including cell wall, score: 9 YP_001571619.1 KEGG: cvi:CV0024 3.2e-07 probable hydroxyethylTHIazole kinase K00878; COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001571620.1 KEGG: nwi:Nwi_1143 0.0079 helix-turn-helix, fis-type K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001571621.1 Psort location: extracellular, including cell wall, score: 9 YP_001571622.1 KEGG: dde:Dde_3688 0.0035 acetyltransferase, CysE/LacA/LpxA/NodL family K00633; COG: COG4104 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571623.1 COG: NOG27576 non supervised orthologous group; Psort location: golgi, score: 9 YP_001571624.1 KEGG: cch:Cag_0702 4.9e-16 probable phage-related lysozyme K01185; COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001571625.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001571626.1 KEGG: eci:UTI89_C3197 0. ClpB protein K01358; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001571627.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001571628.1 KEGG: bxe:Bxe_A4171 0.0052 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: endoplasmic reticulum, score: 9 YP_001571629.1 COG: COG3455 Uncharacterized protein conserved in bacteria; Psort location: vesicles of secretory system, score: 9 YP_001571630.1 COG: COG3522 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571631.1 KEGG: bpm:BURPS1710b_A0534 1.0e-115 hypothetical protein K00356; COG: COG3517 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571632.1 COG: COG3516 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001571633.1 KEGG: nwi:Nwi_1143 3.8e-09 helix-turn-helix, fis-type K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001571634.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001571635.1 Psort location: endoplasmic reticulum, score: 9 YP_001571636.1 KEGG: lsl:LSL_1527 3.7e-16 O-acetyl transferase K00680; COG: COG3594 Fucose 4-O-acetylase and related acetyltransferases; Psort location: plasma membrane, score: 23 YP_001571637.1 COG: NOG23139 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571638.1 Psort location: nuclear, score: 23 YP_001571639.1 COG: COG1835 Predicted acyltransferases; Psort location: nuclear, score: 23 YP_001571640.1 COG: NOG21185 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571641.1 COG: NOG27003 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571642.1 COG: NOG35461 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571643.1 COG: NOG20264 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571644.1 COG: NOG35717 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571645.1 Psort location: cytoplasmic, score: 23 YP_001571646.1 COG: NOG20265 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571647.1 COG: NOG20266 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571648.1 COG: NOG10141 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571649.1 COG: COG5565 Bacteriophage terminase large (ATPase) subunit and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001571650.1 Psort location: cytoplasmic, score: 23 YP_001571651.1 Psort location: cytoplasmic, score: 23 YP_001571652.1 Psort location: cytoplasmic, score: 23 YP_001571653.1 Psort location: nuclear, score: 23 YP_001571654.1 KEGG: ssn:SSO_2782 2.0e-39 ybcT; endopeptidase-like protein K01423; COG: NOG28105 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001571655.1 KEGG: sec:SC2614 2.4e-27 lycV; Gifsy-2 prophage lysozyme K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: cytoplasmic, score: 23 YP_001571656.1 KEGG: sto:ST2057 0.0051 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphstransferase K01001; COG: NOG33147 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571657.1 COG: NOG09845 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571658.1 Psort location: nuclear, score: 23 YP_001571659.1 COG: NOG14016 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571660.1 DLP12 prophage YP_001571661.1 Psort location: mitochondrial, score: 23 YP_001571662.1 Psort location: cytoplasmic, score: 23 YP_001571663.1 KEGG: ecs:ECs1190 3.9e-249 replication protein P K02314; COG: COG0305 Replicative DNA helicase; Psort location: cytoplasmic, score: 23 YP_001571664.1 COG: NOG24180 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571665.1 Psort location: nuclear, score: 23 YP_001571666.1 Psort location: mitochondrial, score: 23 YP_001571667.1 Psort location: cytoplasmic, score: 23 YP_001571668.1 KEGG: cya:CYA_1992 0.0010 peptidase, S24 (LexA) family; COG: COG2932 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571669.1 COG: NOG08577 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571670.1 Psort location: cytoplasmic, score: 23 YP_001571671.1 Psort location: mitochondrial, score: 23 YP_001571672.1 KEGG: cal:orf19.4072 8.0e-25 HYR10; similar to cell surface flocculin K01186; COG: COG5164 Transcription elongation factor; Psort location: nuclear, score: 23 YP_001571673.1 Psort location: cytoplasmic, score: 23 YP_001571674.1 COG: COG4712 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571675.1 Psort location: nuclear, score: 23 YP_001571676.1 Psort location: nuclear, score: 23 YP_001571677.1 Psort location: cytoplasmic, score: 23 YP_001571678.1 Psort location: mitochondrial, score: 23 YP_001571679.1 Psort location: cytoplasmic, score: 23 YP_001571680.1 Psort location: nuclear, score: 23 YP_001571681.1 Psort location: cytoplasmic, score: 23 YP_001571682.1 COG: NOG18119 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571683.1 Psort location: nuclear, score: 23 YP_001571684.1 COG: NOG13881 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571685.1 Psort location: cytoplasmic, score: 23 YP_001571686.1 Psort location: cytoplasmic, score: 23 YP_001571687.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001571688.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001571689.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001571690.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001571691.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_001571692.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_001571693.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001571694.1 KEGG: stm:STM0316 1.1e-253 pepD; aminoacyl-histidine dipeptidase K01270; COG: COG2195 Di- and tripeptidases; Psort location: mitochondrial, score: 23 YP_001571695.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001571696.1 COG: COG3034 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001571697.1 KEGG: reh:H16_A0476 4.4e-67 predicted glutamine amidotransferase class II; COG: COG0121 Predicted glutamine amidotransferase; Psort location: cytoplasmic, score: 23 YP_001571698.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001571699.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_001571700.1 KEGG: eco:b0219 3.3e-110 yafV; predicted C-N hydrolase family amidase, NAD(P)-binding; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001571701.1 COG: COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein; Psort location: extracellular, including cell wall, score: 23 YP_001571702.1 Psort location: cytoplasmic, score: 23 YP_001571703.1 Psort location: cytoplasmic, score: 23 YP_001571704.1 KEGG: psp:PSPPH_3466 0.0097 aldehyde dehydrogenase family protein K00128; COG: COG3637 Opacity protein and related surface antigens; Psort location: endoplasmic reticulum, score: 9 YP_001571705.1 Psort location: cytoplasmic, score: 23 YP_001571706.1 Psort location: cytoplasmic, score: 23 YP_001571707.1 COG: COG3515 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001571708.1 KEGG: rno:309804 1.4e-05 Cdc2l6_predicted; cell division cycle 2-like 6 (CDK8-like) (predicted) K02208; COG: NOG22681 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571709.1 Psort location: cytoplasmic, score: 23 YP_001571710.1 COG: COG3518 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571711.1 COG: COG3521 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001571712.1 COG: COG3520 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571713.1 COG: COG3519 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571714.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001571715.1 Psort location: extracellular, including cell wall, score: 23 YP_001571716.1 COG: COG3515 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571717.1 COG: COG3515 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001571718.1 COG: COG3523 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001571719.1 COG: NOG27999 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571720.1 KEGG: cta:CTA_0154 3.1e-22 serine/threonine-protein kinase PKN1 K00924; COG: COG1262 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001571721.1 COG: NOG28037 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571722.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571723.1 Psort location: endoplasmic reticulum, score: 9 YP_001571724.1 Psort location: mitochondrial, score: 23 YP_001571725.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571726.1 KEGG: eci:UTI89_C3197 0. ClpB protein K01358; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001571727.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001571728.1 COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: endoplasmic reticulum, score: 9 YP_001571729.1 COG: COG3455 Uncharacterized protein conserved in bacteria; Psort location: vesicles of secretory system, score: 9 YP_001571730.1 COG: COG3522 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571731.1 KEGG: bpm:BURPS1710b_A0534 1.0e-115 hypothetical protein K00356; COG: COG3517 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571732.1 COG: COG3516 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001571733.1 COG: NOG38800 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571734.1 COG: NOG06321 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001571735.1 3'-5' exonuclease of DNA polymerase III YP_001571736.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001571737.1 KEGG: vfi:VF1937 1.6e-46 methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001571738.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_001571739.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_001571740.1 COG: COG3021 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571741.1 KEGG: shn:Shewana3_3435 4.4e-09 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571742.1 Psort location: cytoplasmic, score: 23 YP_001571744.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_001571745.1 part of the metNIQ transport system for methionine YP_001571746.1 part of the MetNIQ methionine uptake system YP_001571747.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001571748.1 COG: NOG09836 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571749.1 KEGG: eci:UTI89_C0211 6.6e-112 yaeB; hypothetical protein YaeB; COG: COG1720 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001571750.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001571751.1 COG: COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance; Psort location: mitochondrial, score: 23 YP_001571752.1 KEGG: reh:H16_A3611 4.7e-31 pth2; peptidyl-tRNA hydrolase; COG: COG1186 Protein chain release factor B; Psort location: nuclear, score: 23 YP_001571753.1 KEGG: bpm:BURPS1710b_0319 9.3e-42 YaeQ protein K00356; COG: COG4681 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571754.1 COG: NOG13866 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571755.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_001571756.1 KEGG: stt:t0238 3.0e-178 mesJ; cell cycle protein MesJ K04075; COG: COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; Psort location: cytoplasmic, score: 23 YP_001571757.1 Psort location: nuclear, score: 23 YP_001571758.1 KEGG: stm:STM0235 3.9e-66 yaeR; putative lactoylglutaTHIone lyase K01759; COG: COG0346 LactoylglutaTHIone lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001571759.1 KEGG: sec:SC0234 0. ldcC; lysine decarboxylase 2, constitutive K01582; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001571760.1 KEGG: bam:Bamb_1428 2.2e-32 chitinase K01183; COG: COG3979 Uncharacterized protein contain chitin-binding domain type 3; Psort location: mitochondrial, score: 23 YP_001571761.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001571762.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001571763.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001571764.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001571765.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001571766.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001571767.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001571768.1 COG: COG2825 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001571769.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_001571770.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_001571771.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_001571772.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001571773.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001571774.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001571775.1 Psort location: cytoplasmic, score: 23 YP_001571776.1 Catalyzes the phosphorylation of UMP to UDP YP_001571777.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001571778.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001571779.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001571780.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001571781.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001571782.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571783.1 COG: NOG09673 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571784.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_001571785.1 protease Do; required at high temperature; degrades damaged proteins YP_001571786.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_001571787.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001571788.1 solute binding component of the vitamin B12 transport system BtuCDF YP_001571789.1 COG: COG2860 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001571790.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_001571791.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_001571792.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001571793.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001571794.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_001571795.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_001571796.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_001571797.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_001571798.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_001571799.1 KEGG: sec:SC0188 1.9e-91 ligT; 2'-5' RNA ligase K01975; COG: COG1514 2-5 RNA ligase; Psort location: cytoplasmic, score: 23 YP_001571800.1 Regulatory factor involved in maltose metabolism YP_001571801.1 COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001571802.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_001571803.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_001571804.1 Psort location: nuclear, score: 23 YP_001571805.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP YP_001571806.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001571807.1 KEGG: ssn:SSO_0141 9.3e-129 panC; pantothenate synthetase K01918; COG: COG0414 Panthothenate synthetase; Psort location: cytoplasmic, score: 23 YP_001571808.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001571809.1 KEGG: azo:azo2324 1.3e-19 putative polysaccharide deacetylase; COG: COG0726 Predicted xylanase/chitin deacetylase; Psort location: extracellular, including cell wall, score: 9 YP_001571810.1 KEGG: sty:STY0196 3.1e-73 yadI; putative PTS system IIA component K02821; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001571811.1 COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: plasma membrane, score: 23 YP_001571812.1 KEGG: pen:PSEEN1596 9.8e-102 ABC transporter, ATP-binding protein; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001571813.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_001571814.1 KEGG: sec:SC0170 2.4e-91 hpt; hypoxanTHIne phosphoribosyltransferase K00760; COG: COG0634 HypoxanTHIne-guanine phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001571815.1 KEGG: stm:STM0169 0. gcd; glucose dehydrogenase K00117; COG: COG4993 Glucose dehydrogenase; Psort location: plasma membrane, score: 23 YP_001571816.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_001571817.1 COG: NOG09835 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571818.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001571819.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_001571820.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown YP_001571821.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_001571822.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon YP_001571823.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer YP_001571824.1 COG: COG3112 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001571825.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001571826.1 COG: NOG06276 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571827.1 COG: NOG09806 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001571828.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001571829.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_001571830.1 Psort location: endoplasmic reticulum, score: 9 YP_001571831.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001571832.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_001571833.1 KEGG: eci:UTI89_C0120 3.3e-227 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001571834.1 Psort location: cytoplasmic, score: 23 YP_001571835.1 KEGG: eci:UTI89_C4210 1.3e-113 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001571836.1 KEGG: sde:Sde_0777 7.6e-102 ribosomal protein L11 methyltransferase K01209; COG: COG3940 Predicted beta-xylosidase; Psort location: cytoplasmic, score: 23 YP_001571837.1 involved in regulation of beta-lactamase; putative signaling protein YP_001571838.1 KEGG: eci:UTI89_C0118 1.4e-86 ampD; AmpD protein K03806; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: cytoplasmic, score: 23 YP_001571839.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001571840.1 COG: COG4969 Tfp pilus assembly protein, major pilin PilA; Psort location: mitochondrial, score: 23 YP_001571841.1 KEGG: pen:PSEEN2333 2.5e-80 xcpR-2; type II secretion pathway protein E K01509; COG: COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Psort location: cytoplasmic, score: 23 YP_001571842.1 COG: COG1459 Type II secretory pathway, component PulF; Psort location: endoplasmic reticulum, score: 9 YP_001571843.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_001571844.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001571845.1 COG: COG4582 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571846.1 KEGG: gbe:GbCGDNIH1_1027 0.00019 ribonuclease G; COG: COG3024 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571847.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571848.1 COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: nuclear, score: 23 YP_001571849.1 KEGG: stt:t0141 6.4e-66 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001571850.1 Psort location: cytoplasmic, score: 23 YP_001571851.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001571852.1 secM translational pause allows for the initiation of secA translation YP_001571853.1 Psort location: golgi, score: 9 YP_001571854.1 KEGG: ddi:DDB0167703 0.0025 hypothetical protein K01971; COG: COG5022 Myosin heavy chain; Psort location: nuclear, score: 23 YP_001571855.1 Psort location: nuclear, score: 23 YP_001571856.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001571857.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001571858.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_001571859.1 involved in septum formation YP_001571860.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001571861.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001571862.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001571863.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_001571864.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001571865.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001571866.1 KEGG: spt:SPA0126 5.0e-233 murF; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diami nopimelate--D-alan alanyl ligase K01929; COG: COG0770 UDP-N-acetylmuramyl pentapeptide synthase; Psort location: cytoplasmic, score: 23 YP_001571867.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001571868.1 KEGG: stt:t0126 0. ftsI; penicillin-binding protein 3 precursor K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: mitochondrial, score: 23 YP_001571869.1 Psort location: cytoplasmic, score: 23 YP_001571870.1 membrane bound cell division protein at septum containing leucine zipper motif YP_001571871.1 KEGG: stm:STM0120 4.4e-161 yabC; putative S-adenosyl meTHIonine adenyltransferase K03438; COG: COG0275 Predicted S-adenosylmeTHIonine-dependent methyltransferase involved in cell envelope biogenesis; Psort location: cytoplasmic, score: 23 YP_001571872.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001571873.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_001571874.1 Psort location: cytoplasmic, score: 23 YP_001571875.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001571876.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_001571877.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_001571878.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001571879.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001571880.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001571881.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001571882.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571883.1 Psort location: cytoplasmic, score: 23 YP_001571884.1 activates sgrS under glucose-phosphate stress conditions YP_001571885.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_001571886.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_001571887.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_001571888.1 KEGG: lsl:LSL_1322 0.0029 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: plasma membrane, score: 23 YP_001571889.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_001571890.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_001571891.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001571892.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001571893.1 COG: NOG28502 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571894.1 Psort location: nuclear, score: 23 YP_001571895.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_001571896.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001571897.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_001571898.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_001571899.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_001571900.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_001571901.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001571902.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001571903.1 protein associated with Co2+ and Mg2+ efflux YP_001571904.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001571905.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_001571906.1 transport system that facilitates potassium-efflux YP_001571907.1 Required for full activity of KefC, a potassium-proton antiporter YP_001571908.1 KEGG: efa:EF0685 0.0030 rotamase family protein K07533; COG: NOG17119 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001571909.1 KEGG: cal:orf19.4384 4.7e-15 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001571910.1 KEGG: hma:rrnAC0094 1.7e-05 ydiS; flavoprotein probably electron transport K00313; COG: COG2440 Ferredoxin-like protein; Psort location: cytoplasmic, score: 23 YP_001571911.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction YP_001571912.1 involved in electron transfer during carnitine metabolism YP_001571913.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase YP_001571914.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_001571915.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_001571916.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine YP_001571917.1 KEGG: stm:STM0071 2.8e-239 caiC; crotonobetaine/carnitine-CoA ligase K02182; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: endoplasmic reticulum, score: 9 YP_001571918.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_001571919.1 KEGG: reh:H16_B0315 2.2e-136 arylsulfatase K01130; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001571920.1 Psort location: nuclear, score: 23 YP_001571921.1 Psort location: endoplasmic reticulum, score: 9 YP_001571922.1 Psort location: cytoplasmic, score: 23 YP_001571923.1 COG: NOG27675 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571924.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons YP_001571925.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001571926.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001571927.1 Psort location: cytoplasmic, score: 23 YP_001571928.1 Psort location: nuclear, score: 23 YP_001571929.1 Psort location: cytoplasmic, score: 23 YP_001571930.1 Psort location: cytoplasmic, score: 23 YP_001571931.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001571932.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_001571933.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001571934.1 KEGG: sec:SC0042 9.2e-74 slpA; FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) K03774; COG: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; Psort location: extracellular, including cell wall, score: 9 YP_001571935.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001571936.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001571937.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001571938.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001571939.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_001571940.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001571941.1 KEGG: lpl:lp_1381 3.0e-26 astA; arylsulfate sulfotransferase K01023; COG: NOG14107 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571942.1 COG: NOG26060 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001571943.1 KEGG: syg:sync_2368 6.6e-16 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001571944.1 KEGG: eci:UTI89_C0020 7.5e-246 hypothetical protein K01134; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: extracellular, including cell wall, score: 9 YP_001571945.1 COG: NOG25516 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571946.1 KEGG: eci:UTI89_C4528 5.3e-165 hypothetical protein K01119; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: extracellular, including cell wall, score: 9 YP_001571947.1 KEGG: lpl:lp_1381 7.2e-22 astA; arylsulfate sulfotransferase K01023; COG: NOG14106 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571948.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: vesicles of secretory system, score: 9 YP_001571949.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001571950.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: vesicles of secretory system, score: 9 YP_001571951.1 COG: NOG31826 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571952.1 KEGG: mca:MCA2602 0.0073 dsbA; THIol:disulfide interchange protein DsbA K03673; COG: COG1651 Protein-disulfide isomerase; Psort location: extracellular, including cell wall, score: 9 YP_001571953.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001571954.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001571955.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001571956.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001571957.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: mitochondrial, score: 23 YP_001571958.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001571959.1 KEGG: bme:BMEII0149 0.0099 extracellular serine protease; COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001571960.1 COG: NOG25589 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571961.1 KEGG: vch:VCA0027 1.2e-49 chitinase K01183; COG: COG3325 Chitinase; Psort location: cytoplasmic, score: 23 YP_001571962.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: nuclear, score: 23 YP_001571963.1 COG: COG3926 Putative secretion activating protein; Psort location: cytoskeletal, score: 9 YP_001571964.1 COG: NOG17566 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001571965.1 COG: COG0583 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001571966.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001571967.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001571968.1 COG: COG1961 Site-specific recombinases, DNA invertase Pin homologs; Psort location: cytoplasmic, score: 23 YP_001571969.1 COG: COG1584 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001571970.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001571971.1 COG: COG5464 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001571972.1 KEGG: stt:t0007 1.3e-163 talB; transaldolase B K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001571973.1 KEGG: hpa:HPAG1_0925 4.5e-65 D-alanine glycine permease K01613; COG: COG1115 Na+/alanine symporter; Psort location: plasma membrane, score: 23 YP_001571974.1 COG: COG3022 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001571975.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001571976.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001571977.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001571978.1 member of the SPOUT superfamily of methyltransferases YP_001571979.1 KEGG: eci:UTI89_C5174 6.1e-125 arcA; ArcA transcriptional dual regulator K07773; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001571980.1 Psort location: nuclear, score: 23 YP_001571981.1 COG: COG4452 Inner membrane protein involved in colicin E2 resistance; Psort location: mitochondrial, score: 23 YP_001571982.1 COG: COG3045 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001571983.1 KEGG: bat:BAS3585 2.2e-08 Ada regulatory protein/6-O-methylguanine-DNA methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001571984.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_001571985.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_001571986.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_001571987.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_001571988.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001571989.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001571990.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001571991.1 catalyzes the formation of serine from O-phosphoserine YP_001571992.1 KEGG: ece:Z5988 1.9e-98 putative lipoate-protein ligase A K03800:K07186; COG: COG3726 Uncharacterized membrane protein affecting hemolysin expression; Psort location: endoplasmic reticulum, score: 9 YP_001571993.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_001571994.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001571995.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001571996.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_001571997.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001571998.1 COG: NOG06143 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001571999.1 KEGG: vfi:VFA0962 7.5e-40 pyruvate formate-lyase activating enzyme K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001572000.1 KEGG: sec:SC4412 8.6e-126 yjjV; putative hydrolase K03424; COG: COG0084 Mg-dependent DNase; Psort location: cytoplasmic, score: 23 YP_001572001.1 KEGG: vfi:VFA0008 4.3e-37 phospholipase; COG: COG4667 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: cytoplasmic, score: 23 YP_001572002.1 COG: NOG16919 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001572003.1 Psort location: extracellular, including cell wall, score: 9 YP_001572004.1 KEGG: hit:NTHI0707 0.00029 fkbY; probable FKBP-type peptidyl-prolyl cis-trans isomerase K03772; COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001572005.1 Psort location: cytoplasmic, score: 23 YP_001572006.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001572007.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_001572008.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_001572009.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_001572010.1 COG: NOG09784 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572011.1 KEGG: syn:sll1687 1.1e-25 hik17; hypothetical protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001572012.1 KEGG: gbe:GbCGDNIH1_2380 0.00017 ferric hydroxamate reductase FhuF K00521; COG: COG4114 Uncharacterized Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001572013.1 KEGG: bcl:ABC2234 3.6e-08 proS, pro; prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001572014.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_001572015.1 COG: NOG09075 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572016.1 Psort location: extracellular, including cell wall, score: 9 YP_001572017.1 COG: COG2966 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001572018.1 COG: COG3610 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001572019.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_001572020.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_001572021.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_001572022.1 KEGG: lwe:lwe2018 1.1e-43 sugar isomerase domain protein; COG: COG2222 Predicted phosphosugar isomerases; Psort location: cytoplasmic, score: 23 YP_001572023.1 KEGG: lwe:lwe2019 6.4e-50 glucosamine--fructose-6-phosphate aminotransferase , putative K00820; COG: COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; Psort location: endoplasmic reticulum, score: 9 YP_001572024.1 KEGG: hso:HS_0607 1.1e-54 manZ; protein-N(pi)-phosphohistidine-sugar phosphotransferase (mannose-specific phosphotransferase system IID component) K02796; COG: COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; Psort location: plasma membrane, score: 23 YP_001572025.1 KEGG: lsl:LSL_1715 2.0e-32 PTS system, mannose-specific IIC component K00890; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001572026.1 KEGG: sec:SC4388 9.2e-74 ptrB; putative PTS permease K02794; COG: COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001572027.1 KEGG: sec:SC4387 5.6e-67 putative PTS permease K02793; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001572028.1 KEGG: reh:H16_A2683 3.3e-28 response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K01529; COG: COG3933 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001572029.1 Psort location: cytoplasmic, score: 23 YP_001572030.1 KEGG: syn:sll1871 1.8e-06 hik6; two-component sensor histidine kinase K02486; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001572031.1 COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001572032.1 COG: COG2879 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001572033.1 KEGG: reh:H16_A0195 7.0e-60 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001572034.1 KEGG: tdn:Tmden_1946 3.0e-08 transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001572035.1 KEGG: rme:Rmet_3499 0.0052 ATP synthase F0, C subunit K02110; COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001572036.1 COG: COG3586 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001572037.1 COG: COG5457 Uncharacterized conserved small protein; Psort location: cytoplasmic, score: 23 YP_001572038.1 KEGG: stm:STM4519 3.0e-233 putative NAD-dependent aldehyde dehydrogenase K00135; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001572039.1 KEGG: shn:Shewana3_1692 0.00070 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572040.1 COG: COG2733 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572041.1 KEGG: eci:UTI89_C5041 9.3e-145 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572042.1 KEGG: nha:Nham_4600 1.1e-09 feruloyl esterase; COG: COG3335 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001572043.1 COG: COG3314 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001572044.1 COG: COG0700 Uncharacterized membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572045.1 KEGG: spt:SPA4332 1.1e-198 iadA; probable isoaspartyl dipeptidase K01305; COG: NOG06797 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572046.1 KEGG: shn:Shewana3_3435 7.8e-13 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572047.1 KEGG: eca:ECA1500 4.5e-49 probable aspartate racemase K01779; COG: COG1794 Aspartate racemase; Psort location: cytoplasmic, score: 23 YP_001572048.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001572049.1 COG: NOG34393 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572050.1 KEGG: spt:SPA4327 1.7e-19 trpS-like protein K01867; Psort location: cytoplasmic, score: 23 YP_001572051.1 regulates the expression of uxuBA YP_001572052.1 Psort location: endoplasmic reticulum, score: 9 YP_001572053.1 KEGG: rfr:Rfer_3810 2.9e-08 carboxymethylenebutenolidase K01061; COG: COG0412 Dienelactone hydrolase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572054.1 COG: COG3439 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001572055.1 COG: NOG08605 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572056.1 Psort location: cytoplasmic, score: 23 YP_001572057.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572058.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23; ORF located using Blastx YP_001572059.1 COG: COG3547 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001572060.1 COG: COG3547 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001572061.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572062.1 Psort location: nuclear, score: 23 YP_001572063.1 Psort location: cytoplasmic, score: 23 YP_001572064.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001572065.1 KEGG: fal:FRAAL2247 1.4e-11 chromosome partitioning protein (partial match) K08253; COG: COG1192 ATPases involved in chromosome partitioning; Psort location: endoplasmic reticulum, score: 9 YP_001572066.1 COG: COG1192 ATPases involved in chromosome partitioning; Psort location: mitochondrial, score: 23 YP_001572067.1 Psort location: mitochondrial, score: 23 YP_001572068.1 KEGG: plu:plu1031 2.4e-123 unnamed protein product; similar to DNA helicase K02314; COG: COG0305 Replicative DNA helicase; Psort location: nuclear, score: 23 YP_001572069.1 COG: NOG06299 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572070.1 COG: NOG11459 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572071.1 COG: NOG08740 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572072.1 Psort location: cytoplasmic, score: 23 YP_001572073.1 Psort location: nuclear, score: 23 YP_001572074.1 Psort location: nuclear, score: 23 YP_001572075.1 Psort location: cytoplasmic, score: 23 YP_001572076.1 COG: COG3210 Large exoproteins involved in heme utilization or adhesion; Psort location: cytoplasmic, score: 23 YP_001572077.1 KEGG: nha:Nham_4600 1.1e-09 feruloyl esterase; COG: COG3335 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001572078.1 Psort location: nuclear, score: 23 YP_001572079.1 KEGG: eci:UTI89_C0334 5.4e-34 hypothetical protein; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: extracellular, including cell wall, score: 9 YP_001572080.1 Psort location: cytoplasmic, score: 23 YP_001572081.1 COG: COG3177 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001572082.1 COG: NOG07802 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572083.1 COG: NOG11060 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572084.1 COG: NOG13362 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572085.1 COG: NOG08741 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572086.1 Psort location: extracellular, including cell wall, score: 9 YP_001572087.1 COG: NOG14148 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572088.1 COG: NOG08743 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572089.1 COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001572090.1 COG: NOG13628 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572091.1 COG: NOG06089 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572092.1 Psort location: cytoplasmic, score: 23 YP_001572093.1 COG: NOG08744 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572094.1 COG: NOG14807 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572095.1 COG: NOG11851 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572096.1 COG: NOG10986 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572097.1 COG: NOG17699 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572098.1 COG: NOG18546 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572099.1 COG: NOG17700 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572100.1 COG: NOG17701 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572101.1 COG: NOG07920 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572102.1 COG: NOG07921 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572103.1 COG: NOG06300 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572104.1 COG: NOG14028 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572105.1 COG: NOG06090 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572106.1 Psort location: nuclear, score: 23 YP_001572107.1 Psort location: cytoplasmic, score: 23 YP_001572108.1 Psort location: endoplasmic reticulum, score: 9 YP_001572109.1 KEGG: eci:UTI89_C0121 0.0053 usp; uropathogenic specific protein K01150; COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001572110.1 COG: NOG18931 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572111.1 COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572112.1 KEGG: reh:H16_A1411 0.0078 shikimate kinase containing a XRE-type HTH DNA-binding domain K00924; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572113.1 COG: COG3423 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001572114.1 COG: COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases; Psort location: cytoplasmic, score: 23 YP_001572115.1 KEGG: plu:plu0338 2.1e-193 dcm; DNA-cytosine methyltransferase K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001572116.1 KEGG: nme:NMB1289 4.5e-49 type II restriction enzyme, putative K01155; COG: NOG14036 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572117.1 KEGG: syg:sync_2368 3.4e-13 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001572118.1 COG: COG0730 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001572119.1 KEGG: pmu:PM1682 8.0e-107 putative sulfatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572120.1 KEGG: eci:UTI89_C3355 5.3e-07 nupG; transport of nucleosides, permease protein K03289; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572121.1 KEGG: mmu:27419 1.8e-86 Naglu; alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) K01205; COG: NOG36584 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572122.1 Psort location: extracellular, including cell wall, score: 9 YP_001572123.1 KEGG: sru:SRU_2844 2.9e-08 beta-glucanase precursor K01216; COG: COG2273 Beta-glucanase/Beta-glucan synthetase; Psort location: cytoplasmic, score: 23 YP_001572124.1 COG: NOG06091 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572125.1 COG: NOG06092 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572126.1 Psort location: extracellular, including cell wall, score: 23 YP_001572127.1 COG: NOG06088 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572128.1 KEGG: cac:CAC3534 1.0e-51 site-specific modification DNA-methyltransferase K07317; COG: COG0827 Adenine-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001572129.1 KEGG: mba:Mbar_A3242 0.0029 DNA-(apurinic or apyrimidinic site) lyase K01142; Psort location: mitochondrial, score: 23 YP_001572130.1 Psort location: nuclear, score: 23 YP_001572131.1 KEGG: azo:azo0358 4.8e-29 putative two-component sensor kinase; COG: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; Psort location: nuclear, score: 23 YP_001572132.1 COG: COG3440 Predicted restriction endonuclease; Psort location: cytoplasmic, score: 23 YP_001572133.1 COG: NOG18549 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572134.1 KEGG: vfi:VFB02 6.0e-54 traC; DNA primase TraC; COG: COG4227 Antirestriction protein; Psort location: cytoplasmic, score: 23 YP_001572135.1 COG: NOG08745 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572136.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001572137.1 Psort location: cytoplasmic, score: 23 YP_001572138.1 KEGG: eci:UTI89_C4876 1.4e-166 yjgB; putative oxidoreductase K00100; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001572139.1 KEGG: stm:STM4485 3.1e-82 idnK; thermosensitive D-gluconate kinase K00851; COG: COG3265 Gluconate kinase; Psort location: nuclear, score: 23 YP_001572140.1 KEGG: spt:SPA4284 6.3e-43 idnD; L-idonate 5-dehydrogenase K00098; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: mitochondrial, score: 23 YP_001572141.1 KEGG: stm:STM4483 2.3e-38 idnO; 5-keto-D-gluconate-5-reductase K00046; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: vacuolar, score: 9 YP_001572142.1 KEGG: eci:UTI89_C3106 0.00045 ygbN; hypothetical permease YgbN K03299; COG: COG1609 Transcriptional regulators; Psort location: extracellular, including cell wall, score: 9 YP_001572143.1 KEGG: reh:H16_A0917 4.3e-163 predicted ATPase K01529; COG: COG0433 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001572144.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001572145.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001572146.1 Psort location: nuclear, score: 23 YP_001572147.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001572148.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001572149.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001572150.1 Psort location: endoplasmic reticulum, score: 9 YP_001572151.1 KEGG: pen:PSEEN5483 2.6e-12 lipase K01066; COG: COG3675 Predicted lipase; Psort location: cytoplasmic, score: 23 YP_001572152.1 Psort location: cytoplasmic, score: 23 YP_001572153.1 Psort location: cytoplasmic, score: 23 YP_001572154.1 Psort location: nuclear, score: 23 YP_001572155.1 KEGG: stt:t4508 1.9e-50 putative acetyltransferase K03828; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001572156.1 Psort location: mitochondrial, score: 23 YP_001572157.1 KEGG: sty:STY4809 1.0e-131 miaE; tRNA hydroxylase K06169; COG: COG4445 Hydroxylase for synthesis of 2-methylTHIo-cis-ribozeatin in tRNA; Psort location: cytoplasmic, score: 23 YP_001572158.1 COG: COG3076 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572159.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III. YP_001572160.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001572161.1 Psort location: mitochondrial, score: 23 YP_001572162.1 Psort location: cytoplasmic, score: 23 YP_001572163.1 catalyzes the degradation of arginine to citruline and ammonia YP_001572164.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001572165.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001572166.1 COG: COG1288 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001572167.1 Psort location: mitochondrial, score: 23 YP_001572168.1 Psort location: endoplasmic reticulum, score: 9 YP_001572169.1 COG: COG1438 Arginine repressor; Psort location: cytoplasmic, score: 23 YP_001572170.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001572171.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_001572172.1 KEGG: ape:APE_1501.1 1.4e-22 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001572173.1 P-type ATPase involved in magnesium influx YP_001572174.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_001572175.1 KEGG: sty:STY4794 3.7e-38 treB; PTS system, trehalose-specific IIBC component K02818:K02819; COG: COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; Psort location: cytoplasmic, score: 23 YP_001572176.1 KEGG: sfl:SF4250 2.1e-25 treB; trehalose specific PTS system enzyme II K02818:K02819; COG: COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific; Psort location: endoplasmic reticulum, score: 9 YP_001572177.1 KEGG: spt:SPA4255 3.2e-96 treB; trehalose-specific IIBC component of PTS system K02818:K02819; COG: COG1264 Phosphotransferase system IIB components; Psort location: endoplasmic reticulum, score: 9 YP_001572178.1 COG: NOG35849 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572179.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001572180.1 KEGG: ssn:SSO_4418 1.4e-47 nrdG; anaerobic ribonucleotide reductase activating protein K04068; COG: COG0602 Organic radical activating enzymes; Psort location: cytoskeletal, score: 9 YP_001572181.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001572182.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_001572183.1 COG: COG3711 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001572184.1 COG: NOG18555 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572185.1 KEGG: stm:STM4006 0.0092 glnL; sensory kinase (phosphatase) in two-component regulatory system with GlnG (nitrogen regulator II, NRII) K07708; COG: NOG18554 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572186.1 KEGG: eco:b4236 3.1e-41 cybC; cytochrome b562, truncated (pseudogene); COG: COG3783 Soluble cytochrome b562; Psort location: extracellular, including cell wall, score: 9 YP_001572187.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_001572188.1 COG: COG3028 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001572189.1 KEGG: stt:t4470 2.4e-240 mpl; murein peptide ligase K02558; COG: COG0773 UDP-N-acetylmuramate-alanine ligase; Psort location: cytoplasmic, score: 23 YP_001572190.1 Psort location: mitochondrial, score: 23 YP_001572191.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001572192.1 Psort location: cytoplasmic, score: 23 YP_001572193.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001572194.1 Psort location: endoplasmic reticulum, score: 9 YP_001572195.1 KEGG: eci:UTI89_C0121 8.6e-55 usp; uropathogenic specific protein K01150; COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001572196.1 Psort location: endoplasmic reticulum, score: 9 YP_001572197.1 COG: COG2105 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001572198.1 KEGG: bmf:BAB1_0046 1.1e-13 family of unknown function DUF490 K01076; COG: COG2911 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001572199.1 COG: COG0729 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001572200.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001572201.1 KEGG: hpa:HPAG1_1423 9.3e-42 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: endoplasmic reticulum, score: 9 YP_001572202.1 COG: NOG17567 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572203.1 COG: COG3054 Predicted transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001572204.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_001572205.1 Psort location: cytoplasmic, score: 23 YP_001572206.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_001572207.1 COG: COG1733 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572208.1 KEGG: eci:UTI89_C4820 1.2e-112 ytfG; hypothetical protein YtfG; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001572209.1 KEGG: reh:H16_A3257 0.0011 pilD; type IV pilus prepilin leader peptidase 1; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001572210.1 Involved in anaerobic NO protection and iron metabolism YP_001572211.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_001572212.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_001572213.1 KEGG: pen:PSEEN0463 1.9e-07 peptidase, M23/M37 family K01423; COG: COG3061 Cell envelope opacity-associated protein A; Psort location: nuclear, score: 23 YP_001572214.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001572215.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001572216.1 Psort location: cytoplasmic, score: 23 YP_001572217.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001572218.1 binds single-stranded DNA at the primosome assembly site YP_001572219.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001572220.1 Psort location: cytoplasmic, score: 23 YP_001572221.1 COG: NOG35248 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572222.1 COG: NOG11317 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572223.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001572224.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway YP_001572225.1 Psort location: cytoplasmic, score: 23 YP_001572226.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_001572227.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001572228.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001572229.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001572230.1 KEGG: spi:MGAS10750_Spy0162 6.0e-118 metal-dependent hydrolase; COG: COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Psort location: cytoplasmic, score: 23 YP_001572231.1 negative regulator of ulaG and ulaABCDEF YP_001572232.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_001572233.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility YP_001572234.1 COG: NOG11343 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572235.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_001572236.1 KEGG: pen:PSEEN1824 2.9e-17 glutaTHIonylspermidine synthase; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoplasmic, score: 23 YP_001572237.1 COG: COG3766 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572238.1 COG: COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription; Psort location: cytoplasmic, score: 23 YP_001572239.1 COG: COG3789 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572240.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_001572241.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_001572242.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_001572243.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001572244.1 COG: COG3242 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001572245.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_001572246.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_001572247.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_001572248.1 Stimulates the elongation of poly(A) tails YP_001572249.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001572250.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001572251.1 KEGG: stm:STM4358 3.7e-221 amiB; N-acetylmuramoyl-l-alanine amidase II, a murein hydrolase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: extracellular, including cell wall, score: 9 YP_001572252.1 possibly involved in cell wall synthesis YP_001572253.1 KEGG: reh:H16_A1504 1.3e-69 predicted sugar kinase K00924; COG: COG0063 Predicted sugar kinase; Psort location: cytoplasmic, score: 23 YP_001572254.1 COG: COG1600 Uncharacterized Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001572255.1 KEGG: eci:UTI89_C2121 1.5e-25 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001572256.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001572257.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001572258.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001572259.1 KEGG: rno:113960 8.2e-08 Cdc42bpb; Cdc42 binding protein kinase beta K08286; COG: COG3264 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001572260.1 COG: NOG14153 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572261.1 COG: NOG14153 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572262.1 KEGG: eci:UTI89_C0120 3.8e-05 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001572263.1 Psort location: cytoplasmic, score: 23 YP_001572264.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001572265.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001572266.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001572267.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001572268.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_001572269.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_001572270.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations YP_001572271.1 KEGG: ava:Ava_2028 0.00024 two component transcriptional regulator, LuxR family; COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001572272.1 Psort location: extracellular, including cell wall, score: 9 YP_001572273.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001572274.1 KEGG: eci:UTI89_C4744 3.0e-162 yjeK; hypothetical protein YjeK K01843; COG: COG1509 Lysine 2,3-aminomutase; Psort location: cytoplasmic, score: 23 YP_001572275.1 COG: NOG06800 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572276.1 COG: NOG09783 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572277.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001572278.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001572279.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_001572280.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001572281.1 catalyzes the formation of fumarate from aspartate YP_001572282.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001572283.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_001572284.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001572285.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572286.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001572287.1 Psort location: nuclear, score: 23 YP_001572288.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001572289.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001572290.1 Psort location: nuclear, score: 23 YP_001572291.1 COG: COG3423 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001572292.1 COG: NOG27449 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572293.1 Psort location: nuclear, score: 23 YP_001572294.1 COG: NOG14455 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572295.1 KEGG: pfa:PF11_0053 0.0098 PfSNF2L K01509; COG: COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen; Psort location: cytoplasmic, score: 23 YP_001572296.1 Psort location: cytoplasmic, score: 23 YP_001572297.1 KEGG: cgl:NCgl0024 1.8e-12 cgl0025; predicted transcriptional regulator K01529; COG: COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen; Psort location: cytoskeletal, score: 9 YP_001572298.1 KEGG: eci:UTI89_C3737 1.2e-09 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572299.1 Psort location: cytoplasmic, score: 23 YP_001572300.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572301.1 KEGG: bli:BL05281 4.7e-07 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001572302.1 KEGG: pha:PSHAa1916 0.0088 uvrY, sirA; response regulator K07689; COG: NOG31371 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572303.1 KEGG: ava:Ava_1188 8.3e-19 cyclic nucleotide-regulated ABC bacteriocin/lantibiotic exporters K06147; COG: COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain; Psort location: plasma membrane, score: 23 YP_001572304.1 Psort location: extracellular, including cell wall, score: 9 YP_001572305.1 COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001572306.1 KEGG: pfa:MAL13P1.278 0.00037 Ser/Thr protein kinase K00870; COG: COG1196 Chromosome segregation ATPases; Psort location: extracellular, including cell wall, score: 9 YP_001572307.1 COG: NOG07819 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572308.1 Psort location: nuclear, score: 23 YP_001572309.1 KEGG: chu:CHU_2225 1.3e-31 CHU large protein; gliding motility-related protein; possible adhesin AidA-related K01238; COG: COG5295 Autotransporter adhesin; Psort location: nuclear, score: 23 YP_001572310.1 COG: COG3204 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001572311.1 COG: NOG24086 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572312.1 KEGG: vfi:VFA0083 1.4e-24 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: vesicles of secretory system, score: 9 YP_001572313.1 KEGG: sec:SC4185 2.6e-124 dmsC; putative anaerobic dimethyl sulfoxide reductase, subunit C K00397; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001572314.1 KEGG: spt:SPA4124 2.8e-65 dmsB; anaerobic dimethyl sulfoxide reductase subunit B K00397; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001572315.1 Psort location: cytoplasmic, score: 23 YP_001572316.1 KEGG: stm:STM4305.S 0. putative anaerobic dimethylsulfoxide reductase subunit A K00397; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001572317.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_001572318.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_001572319.1 COG: NOG31352 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572320.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_001572321.1 KEGG: stt:t4207 1.2e-291 fumB; fumarate hydratase class I K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001572322.1 COG: COG3647 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572323.1 KEGG: bur:Bcep18194_C7259 2.4e-105 ABC transporter, duplicated ATPase domains; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: nuclear, score: 23 YP_001572324.1 KEGG: bcz:BCZK2057 8.0e-20 macrolide efflux protein K00953; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572325.1 COG: KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain; Psort location: cytoplasmic, score: 23 YP_001572326.1 Psort location: endoplasmic reticulum, score: 9 YP_001572327.1 KEGG: ech:ECH_1107 3.6e-14 THIF; adenylyltransferase ThiF; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 2; Psort location: cytoplasmic, score: 23 YP_001572328.1 COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001572329.1 KEGG: bpm:BURPS1710b_2148 4.9e-05 JmjC domain protein K00476; COG: KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain; Psort location: nuclear, score: 23 YP_001572330.1 Psort location: cytoplasmic, score: 23 YP_001572331.1 Psort location: cytoplasmic, score: 23 YP_001572332.1 KEGG: eci:UTI89_C4210 3.3e-53 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001572333.1 KEGG: stm:STM4298 3.5e-248 melA; alpha-galactosidase K07406; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001572334.1 KEGG: bha:BH0394 2.0e-11 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001572335.1 KEGG: sty:STY4495 0. adi; arginine decarboxylase K01584; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoskeletal, score: 9 YP_001572336.1 KEGG: bli:BL05281 2.7e-05 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001572337.1 KEGG: eci:UTI89_C0120 3.8e-18 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001572338.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_001572339.1 response regulator in two-component regulatory system with BasS YP_001572340.1 KEGG: sec:SC4170 7.7e-173 basS, basR; sensory kinase in two-component regulatory system with BasR K07643; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001572341.1 KEGG: cal:orf19.2425 0.00013 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572342.1 Psort location: nuclear, score: 23 YP_001572343.1 KEGG: eci:UTI89_C4702 7.0e-44 phnA; hypothetical protein PhnA K06193; COG: COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001572344.1 COG: COG2764 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572345.1 KEGG: reh:H16_B1296 9.4e-65 phnC1; ABC-type transporter, ATPase component: PhnT family; COG: COG3638 ABC-type phosphate/phosphonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001572346.1 COG: COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001572347.1 KEGG: baa:BA_0884 1.1e-07 binding-protein-dependent transport systems inner membrane component K00294; COG: COG3639 ABC-type phosphate/phosphonate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001572348.1 COG: COG3624 Uncharacterized enzyme of phosphonate metabolism; Psort location: mitochondrial, score: 23 YP_001572349.1 COG: COG3625 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001572350.1 COG: COG3626 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001572351.1 COG: COG3627 Uncharacterized enzyme of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001572352.1 KEGG: reh:H16_B1284 7.3e-81 phnK; ABC-type phosphonate transport system, ATPase component; COG: COG4107 ABC-type phosphonate transport system, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001572353.1 KEGG: reh:H16_B1283 1.1e-63 phnL; ABC-type phosphonate transport system, ATPase component; COG: COG4778 ABC-type phosphonate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001572354.1 KEGG: sto:ST2546 0.00013 N-acetylglucosamine-6-phosphate deacetylase K01443; COG: COG3454 Metal-dependent hydrolase involved in phosphonate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001572355.1 KEGG: rde:RD1_1528 1.7e-17 nucleoside phosphorylase, C -terminal domain, putative; COG: COG3709 Uncharacterized component of phosphonate metabolism; Psort location: cytoplasmic, score: 23 YP_001572356.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_001572357.1 Psort location: cytoplasmic, score: 23 YP_001572358.1 KEGG: gbe:GbCGDNIH1_1079 0.0074 metal-dependent hydrolase; COG: COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I; Psort location: cytoplasmic, score: 23 YP_001572359.1 KEGG: mtu:Rv3762c 2.7e-147 possible hydrolase; COG: COG2015 Alkyl sulfatase and related hydrolases; Psort location: cytoplasmic, score: 23 YP_001572360.1 COG: NOG29453 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572361.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_001572362.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_001572363.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family YP_001572364.1 Psort location: cytoplasmic, score: 23 YP_001572365.1 KEGG: eci:UTI89_C1133 6.1e-15 hypothetical protein; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: extracellular, including cell wall, score: 9 YP_001572366.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_001572367.1 COG: COG4235 Cytochrome c biogenesis factor; Psort location: nuclear, score: 23 YP_001572368.1 KEGG: pai:PAE2861 1.2e-18 molybdopterin oxidoreductase, membrane subunit K00185; COG: COG3301 Formate-dependent nitrite reductase, membrane component; Psort location: plasma membrane, score: 23 YP_001572369.1 KEGG: vfi:VF1552 4.8e-77 THIosulfate reductase electron transport subunit K04014; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: mitochondrial, score: 23 YP_001572370.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_001572371.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_001572372.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001572373.1 COG: COG3162 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572374.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_001572375.1 KEGG: bcz:BCZK3376 1.8e-36 murein hydrolase export regulator K01238; COG: COG1346 Putative effector of murein hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001572376.1 KEGG: btk:BT9727_3424 2.1e-12 murein hydrolase exporter K06518; COG: COG1380 Putative effector of murein hydrolase LrgA; Psort location: endoplasmic reticulum, score: 9 YP_001572377.1 KEGG: shn:Shewana3_3435 1.3e-58 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572378.1 COG: COG0025 NhaP-type Na+/H+ and K+/H+ antiporters; Psort location: plasma membrane, score: 23 YP_001572379.1 KEGG: bcz:BCZK0244 8.7e-62 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001572380.1 Psort location: cytoplasmic, score: 23 YP_001572381.1 Psort location: nuclear, score: 23 YP_001572382.1 COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572383.1 regulates genes involved in response to oxidative stress YP_001572384.1 COG: NOG13912 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572385.1 Psort location: endoplasmic reticulum, score: 9 YP_001572386.1 KEGG: bat:BAS3585 0.00093 Ada regulatory protein/6-O-methylguanine-DNA methyltransferase K00567; COG: NOG22229 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572387.1 KEGG: reh:H16_B0690 7.1e-51 rtxB2; ABC-type RTX toxin transporter, ATPase and permease components: Prot1E family; COG: COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain; Psort location: plasma membrane, score: 23 YP_001572388.1 KEGG: mmr:Mmar10_2493 2.1e-21 serralysin K01406; COG: NOG39362 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572389.1 KEGG: fnu:FN0522 5.0e-07 exonuclease SBCC K03546; COG: COG0845 Membrane-fusion protein; Psort location: nuclear, score: 23 YP_001572390.1 COG: COG1538 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001572391.1 KEGG: pfa:PFL1155w 0.0032 GTP cyclohydrolase I K01495; COG: NOG07819 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001572392.1 COG: NOG26663 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572393.1 Psort location: cytoplasmic, score: 23 YP_001572394.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_001572395.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001572396.1 COG: NOG26992 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572397.1 COG: NOG29606 non supervised orthologous group; Psort location: vesicles of secretory system, score: 9 YP_001572398.1 COG: COG2315 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001572399.1 COG: COG0432 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001572400.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_001572401.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001572402.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001572403.1 unwinds double stranded DNA YP_001572404.1 KEGG: sty:STY4441 8.7e-165 qor; quinone oxidoreductase K00344; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001572405.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_001572406.1 KEGG: ssn:SSO_4229 4.7e-173 yjbN; hypothetical protein K05539; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001572407.1 KEGG: nme:NMB1395 6.4e-121 alcohol dehydrogenase, zinc-containing K00001; COG: KOG0024 Sorbitol dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001572408.1 COG: NOG11280 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572409.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_001572410.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_001572411.1 COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001572412.1 Represses a number of genes involved in the response to DNA damage YP_001572413.1 KEGG: sty:STY4432 4.3e-60 dgkA; diacylglycerol kinase K00901; COG: COG0818 Diacylglycerol kinase; Psort location: endoplasmic reticulum, score: 9 YP_001572414.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001572415.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_001572416.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_001572417.1 COG: NOG06298 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572418.1 porin involved in the transport of maltose and maltodextrins YP_001572419.1 with malEFG is involved in import of maltose/maltodextrin YP_001572420.1 Psort location: mitochondrial, score: 23 YP_001572421.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001572422.1 Psort location: nuclear, score: 23 YP_001572423.1 with MalKGE is involved in maltose transport into the cell YP_001572424.1 with MalKFE is involved in the transport of maltose into the cell YP_001572425.1 Psort location: cytoplasmic, score: 23 YP_001572426.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter YP_001572427.1 COG: COG3223 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572428.1 COG: NOG06257 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572429.1 COG: NOG06780 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572430.1 COG: NOG06220 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572431.1 COG: NOG14141 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572432.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001572433.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_001572434.1 COG: NOG14139 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572435.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_001572436.1 COG: COG3122 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001572437.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_001572438.1 COG: COG1283 Na+/phosphate symporter; Psort location: endoplasmic reticulum, score: 9 YP_001572439.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001572440.1 Psort location: endoplasmic reticulum, score: 9 YP_001572441.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_001572442.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_001572443.1 KEGG: spt:SPA4022 5.7e-232 aceA; isocitrate lyase K01637; COG: COG2224 Isocitrate lyase; Psort location: cytoplasmic, score: 23 YP_001572444.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_001572445.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_001572446.1 KEGG: stm:STM4181 6.4e-66 yjaB; putative acetyltransferase K03827; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001572447.1 Psort location: cytoplasmic, score: 23 YP_001572448.1 involved in de novo purine biosynthesis YP_001572449.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001572450.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein YP_001572451.1 KEGG: sec:SC4054 1.4e-253 hydH, hydG; sensory kinase in two component regulatory system with HydG K07709; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001572452.1 COG: COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein; Psort location: extracellular, including cell wall, score: 9 YP_001572453.1 COG: NOG06219 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572454.1 histone-like DNA-binding protein YP_001572455.1 COG: COG3068 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572456.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_001572457.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001572458.1 KEGG: sfl:SF4068 1.4e-52 yjaD; NADH pyrophosphatase K03659; COG: COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Psort location: cytoplasmic, score: 23 YP_001572459.1 Psort location: cytoplasmic, score: 23 YP_001572460.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_001572461.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001572462.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_001572463.1 KEGG: eci:UTI89_C3827 2.2e-111 THIF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 2; Psort location: cytoplasmic, score: 23 YP_001572464.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_001572465.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001572466.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_001572467.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572468.1 COG: COG0666 FOG: Ankyrin repeat; Psort location: cytoplasmic, score: 23 YP_001572469.1 Psort location: nuclear, score: 23 YP_001572470.1 Psort location: cytoplasmic, score: 23 YP_001572471.1 COG: NOG25759 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572472.1 COG: COG3385 FOG: Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572473.1 Psort location: cytoplasmic, score: 23 YP_001572474.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001572475.1 Psort location: endoplasmic reticulum, score: 9 YP_001572476.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001572478.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001572479.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001572480.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001572481.1 Psort location: cytoplasmic, score: 23 YP_001572482.1 binds directly to 23S ribosomal RNA YP_001572483.1 Modulates Rho-dependent transcription termination YP_001572484.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001572485.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001572486.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001572487.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001572488.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001572490.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001572491.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_001572492.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_001572493.1 COG: NOG10261 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572494.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_001572495.1 Psort location: cytoplasmic, score: 23 YP_001572496.1 KEGG: sec:SC4015 3.7e-141 udhA; soluble pyridine nucleotide transhydrogenase K00322; COG: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572497.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_001572498.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001572499.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001572500.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001572501.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_001572502.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001572503.1 KEGG: pha:PSHAa2772 6.8e-21 eptA; lipid A phosphoethanolamine transferase, associated with polymyxin resistance K03760; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001572504.1 KEGG: bli:BL05281 1.7e-11 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001572505.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_001572506.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_001572507.1 KEGG: sty:STY3760 0. katG; catalase (hydroperoxidase I) K03782; COG: COG0376 Catalase (peroxidase I); Psort location: endoplasmic reticulum, score: 9 YP_001572508.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_001572509.1 KEGG: eci:UTI89_C4530 7.7e-260 hypothetical protein K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: extracellular, including cell wall, score: 9 YP_001572510.1 COG: NOG06319 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572511.1 Psort location: cytoplasmic, score: 23 YP_001572512.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001572513.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_001572514.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_001572515.1 KEGG: eci:UTI89_C4210 1.8e-38 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001572516.1 COG: NOG25848 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572517.1 COG: COG0254 Ribosomal protein L31; Psort location: cytoplasmic, score: 23 YP_001572518.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001572519.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_001572520.1 KEGG: hsa:6595 8.6e-07 SMARCA2, SNF2L2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 K01529; COG: COG3087 Cell division protein; Psort location: nuclear, score: 23 YP_001572521.2 heat shock protein involved in degradation of misfolded proteins YP_001572522.1 heat shock protein involved in degradation of misfolded proteins YP_001572523.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001572524.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001572525.1 Psort location: mitochondrial, score: 23 YP_001572526.1 KEGG: rno:85240 0.00031 Plcb2; phospholipase C, beta 2 K05858; COG: COG3074 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001572527.1 KEGG: fal:FRAAL3366 0.0042 putative arsenate reductase (partial match); COG: COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Psort location: endoplasmic reticulum, score: 9 YP_001572528.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001572529.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001572530.1 KEGG: stm:STM4084 1.3e-129 fpr; ferredoxin-NADP reductase K00528; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001572531.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572532.1 COG: NOG06218 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572533.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001572534.1 KEGG: ecj:JW3469 0.0040 arsB; arsenite/antimonite transporter K03893; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001572535.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001572536.1 KEGG: sec:SC3955 9.3e-129 ushB; CDP-diacylglycerol phosphotidylhydrolase K01521; COG: COG2134 CDP-diacylglycerol pyrophosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001572537.1 COG: COG1613 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001572538.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001572539.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_001572540.1 Psort location: mitochondrial, score: 23 YP_001572541.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_001572542.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_001572543.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_001572544.1 COG: COG2258 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572545.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_001572546.1 Psort location: mitochondrial, score: 23 YP_001572547.1 COG: NOG25848 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572548.1 Psort location: cytoplasmic, score: 23 YP_001572549.1 KEGG: nha:Nham_4600 1.1e-09 feruloyl esterase; COG: COG3335 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001572550.1 transports L-rhamnose and L-lyxose into the cell YP_001572551.1 activates the expression of rhaRS in response to L-rhamnose YP_001572552.1 activates the expression of the rhaBAD operon and rhaT gene YP_001572553.1 Psort location: nuclear, score: 23 YP_001572554.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_001572555.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_001572556.1 KEGG: sec:SC3935 2.0e-142 rhaD; rhamnulose-1-phosphate aldolase K01629; COG: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Psort location: cytoplasmic, score: 23 YP_001572557.1 KEGG: stm:STM4044 1.1e-189 putative alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001572558.1 KEGG: msm:MSMEG_0587 3.6e-08 rhaU; L-rhamnose 1-epimerase; COG: COG3254 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001572559.1 KEGG: psp:PSPPH_2917 5.5e-09 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572560.1 COG: COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); Psort location: endoplasmic reticulum, score: 9 YP_001572561.1 COG: NOG19750 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572562.1 KEGG: ece:Z5443 1.7e-19 frvA; PTS system, fructose-specific IIA component K02768; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: nuclear, score: 23 YP_001572563.1 KEGG: ssn:SSO_4070 2.2e-24 frvA; PTS system, fructose-specific IIA component K02768; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001572564.1 KEGG: ecs:ECs4825 2.2e-26 fructose-like PTS system enzyme IIBC component K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: nuclear, score: 23 YP_001572565.1 COG: COG0795 Predicted permeases; Psort location: vesicles of secretory system, score: 9 YP_001572566.1 KEGG: sfl:SF3976 3.0e-36 frvB; PTS system, fructose-like enzyme IIBC component K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: endoplasmic reticulum, score: 9 YP_001572567.1 KEGG: sfl:SF3976 1.9e-24 frvB; PTS system, fructose-like enzyme IIBC component K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: cytoplasmic, score: 23 YP_001572568.1 KEGG: eco:b3897 5.2e-25 frvR; predicted regulator K00924; COG: COG3711 Transcriptional antiterminator; Psort location: nuclear, score: 23 YP_001572569.1 KEGG: eco:b3897 4.2e-13 frvR; predicted regulator K00924; COG: COG3711 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001572570.1 Psort location: cytoplasmic, score: 23 YP_001572571.1 COG: NOG13870 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572572.1 Psort location: cytoplasmic, score: 23 YP_001572573.1 Psort location: cytoplasmic, score: 23 YP_001572574.1 Psort location: nuclear, score: 23 YP_001572575.1 COG: NOG06285 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572576.1 COG: COG0845 Membrane-fusion protein; Psort location: mitochondrial, score: 23 YP_001572577.1 KEGG: pen:PSEEN4080 2.8e-152 type I toxin efflux ATP-binding membrane protein; COG: COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain; Psort location: endoplasmic reticulum, score: 9 YP_001572578.1 KEGG: bur:Bcep18194_C7173 0.00019 two component transcriptional regulator, AraC family; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001572579.1 Psort location: extracellular, including cell wall, score: 9 YP_001572580.1 COG: COG2913 Small protein A (tmRNA-binding); Psort location: extracellular, including cell wall, score: 9 YP_001572581.1 KEGG: eci:UTI89_C4143 4.0e-68 putative autotransport adhesin K01423; COG: COG5295 Autotransporter adhesin; Psort location: extracellular, including cell wall, score: 9 YP_001572582.1 Psort location: nuclear, score: 23 YP_001572583.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001572584.1 KEGG: stm:STM4036 3.9e-169 fdoH; formate dehydrogenase-O, Fe-S subunit K00124; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001572585.1 cytochrome b556(FDO) component; heme containing YP_001572586.1 required for the formation of active formate dehydrogenase YP_001572587.1 COG: COG2944 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001572588.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: nuclear, score: 23 YP_001572589.1 KEGG: eci:UTI89_C4473 3.6e-120 putative lipase K01066; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001572590.1 KEGG: eci:UTI89_C4472 1.1e-166 yiiD; putative acetyltransferase K00633; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001572591.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001572592.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_001572593.1 KEGG: lil:LA1476 8.1e-11 putative haloacid dehalogenase-like hydrolase K01560; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001572594.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001572595.1 KEGG: eci:UTI89_C4462 1.8e-100 yihV; hypothetical sugar kinase YihV K00846; COG: COG0524 Sugar kinases, ribokinase family; Psort location: extracellular, including cell wall, score: 9 YP_001572596.1 KEGG: spt:SPA3864 4.5e-152 yihU; putative oxidoreductase K08318; COG: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001572597.1 KEGG: eco:b3881 1.5e-135 yihT; predicted aldolase; COG: COG3684 Tagatose-1,6-bisphosphate aldolase; Psort location: cytoplasmic, score: 23 YP_001572598.1 KEGG: eco:b3880 4.5e-223 yihS; predicted glucosamine isomerase; COG: COG2942 N-acyl-D-glucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001572599.1 KEGG: eco:b3879 5.4e-85 yihR; predicted aldose-1-epimerase K01785; COG: COG2017 Galactose mutarotase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572600.1 KEGG: lil:LA2944 2.7e-129 Alpha-glucosidase II K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001572601.1 KEGG: eci:UTI89_C4210 2.9e-47 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: endoplasmic reticulum, score: 9 YP_001572602.1 KEGG: eci:UTI89_C4210 6.1e-45 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001572603.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_001572604.1 KEGG: eci:UTI89_C4460 0. typA, bipA, yihK, yjhK; putative GTP-binding factor K06207; COG: COG1217 Predicted membrane GTPase involved in stress response; Psort location: cytoplasmic, score: 23 YP_001572605.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_001572606.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_001572607.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_001572608.1 Psort location: extracellular, including cell wall, score: 9 YP_001572609.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001572610.1 COG: COG3078 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001572611.1 KEGG: reh:H16_A3452 1.1e-36 predicted GTPase K01529; COG: COG0218 Predicted GTPase; Psort location: cytoplasmic, score: 23 YP_001572612.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001572613.1 KEGG: eci:UTI89_C4450 5.6e-138 yihG; hypothetical protein YihG K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: cytoplasmic, score: 23 YP_001572614.1 KEGG: bci:BCI_0257 3.8e-52 dsbA; THIol:disulfide interchange protein DsbA K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001572615.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_001572616.1 COG: COG3084 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572617.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001572618.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_001572619.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_001572620.1 KEGG: shn:Shewana3_0031 1.3e-76 potassium uptake protein, TrkH family K00961; COG: COG0168 Trk-type K+ transport systems, membrane components; Psort location: plasma membrane, score: 23 YP_001572621.1 KEGG: eci:UTI89_C4433 4.2e-94 yigZ; hypothetical protein K00560; COG: COG1739 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001572622.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_001572623.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001572624.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001572625.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_001572626.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_001572627.1 COG: COG0250 Transcription antiterminator; Psort location: cytoplasmic, score: 23 YP_001572628.1 magnesium dependent; not involved in the Sec-independent protein export system YP_001572629.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_001572630.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001572631.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001572632.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_001572633.1 COG: COG3165 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572634.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001572635.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_001572636.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_001572637.1 KEGG: stm:STM3967 1.6e-131 dlhH; putative dienelactone hydrolase family K01061; COG: COG0412 Dienelactone hydrolase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572638.1 KEGG: syg:sync_2368 2.8e-17 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001572639.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001572640.1 KEGG: shn:Shewana3_3435 3.4e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572641.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001572642.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_001572643.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_001572644.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001572645.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001572646.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_001572647.1 catalyzes the hydrolysis of phosphatidylcholine YP_001572648.1 COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001572649.1 COG: COG2962 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001572650.1 COG: NOG26268 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572651.1 Psort location: extracellular, including cell wall, score: 9 YP_001572652.1 responsible for the influx of magnesium ions YP_001572653.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001572654.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_001572655.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001572656.1 KEGG: azo:azo0595 2.5e-06 3',5'-cyclic-nucleotide phosphodiesterase K01120; COG: COG3159 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572657.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001572658.1 COG: COG5567 Predicted small periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001572659.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001572660.2 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001572661.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001572662.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_001572663.1 KEGG: sty:STY3623 1.5e-192 hemX; uroporphyrinogen III methylase K02496; COG: COG2959 Uncharacterized enzyme of heme biosynthesis; Psort location: nuclear, score: 23 YP_001572664.1 KEGG: pfo:Pfl_0690 0.0075 exodeoxyribonuclease V, alpha subunit K03581; COG: COG3071 Uncharacterized enzyme of heme biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001572665.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_001572666.1 KEGG: sec:SC3834 4.7e-125 wecG; putative UDP-N-acetyl-D-mannosaminuronic acid transferase K02852; COG: COG1922 Teichoic acid biosynthesis proteins; Psort location: cytoplasmic, score: 23 YP_001572667.1 enterobacterial common antigen polymerase YP_001572668.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_001572669.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001572670.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001572671.1 KEGG: eci:UTI89_C4346 1.9e-80 rffC, rff, wecD, yifH; TDP-fucosamine acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001572672.1 KEGG: sty:STY3632 7.1e-154 rffH; glucose-1-phosphate thymidylyltransferase K00973; COG: COG1209 dTDP-glucose pyrophosphorylase; Psort location: cytoplasmic, score: 23 YP_001572673.1 KEGG: stm:STM3922 3.6e-191 rffG; dTDP-glucose 4,6-dehydratase K01710; COG: COG1088 dTDP-D-glucose 4,6-dehydratase; Psort location: cytoplasmic, score: 23 YP_001572674.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_001572675.1 KEGG: stm:STM3920 4.1e-190 wecB; UDP-N-acetyl glucosamine -2-epimerase K01791; COG: COG0381 UDP-N-acetylglucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001572676.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_001572677.1 KEGG: sec:SC3823 3.5e-193 wecA; undecaprenyl-phosphate alpha-N-acetylglucosaminyl K02851; COG: COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; Psort location: plasma membrane, score: 23 YP_001572678.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001572679.1 KEGG: eci:UTI89_C4335 2.3e-61 trxA; THIoredoxin 1 K03671; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001572680.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001572681.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_001572682.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_001572683.1 COG: COG3201 Nicotinamide mononucleotide transporter; Psort location: plasma membrane, score: 23 YP_001572684.1 KEGG: sty:STY3644 2.1e-124 probable uridine phosphorylase K00757; COG: COG2820 Uridine phosphorylase; Psort location: cytoplasmic, score: 23 YP_001572685.1 KEGG: eci:UTI89_C3860 1.2e-05 crp; CRP-cAMP transcriptional dual regulator K00924; COG: NOG28604 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572686.1 KEGG: spt:SPA3749 1.8e-45 ppiC; peptidyl-prolyl cis-trans isomerase C K03769; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: cytoplasmic, score: 23 YP_001572687.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001572688.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_001572689.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001572690.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001572691.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001572692.1 KEGG: sec:SC3807 2.8e-40 ilvM; acetolactate synthase II, small subunit K01653; COG: COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit; Psort location: cytoplasmic, score: 23 YP_001572693.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_001572694.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function YP_001572695.1 COG: COG3085 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572696.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_001572697.1 KEGG: reh:H16_A3019 0.0043 hutC; histidine utilization repressor; COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572698.1 KEGG: sgl:SG1466 7.9e-09 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572699.1 DNA-binding transcriptional repressor of ribose metabolism YP_001572700.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_001572701.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_001572702.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_001572703.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_001572704.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001572705.1 Psort location: cytoplasmic, score: 23 YP_001572706.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_001572707.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_001572708.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_001572709.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001572710.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_001572711.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001572712.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001572713.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001572714.1 Psort location: mitochondrial, score: 23 YP_001572715.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_001572716.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001572717.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001572718.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001572719.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001572720.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001572721.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001572722.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001572724.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001572725.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001572726.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001572727.1 KEGG: mst:Msp_0343 4.4e-08 pstS; PstS K02040; COG: COG0226 ABC-type phosphate transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001572728.1 Psort location: cytoplasmic, score: 23 YP_001572729.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001572730.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001572731.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001572732.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_001572733.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_001572734.1 KEGG: bcz:BCZK0244 2.4e-89 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001572735.1 KEGG: eci:UTI89_C4266 4.7e-86 yieF; hypothetical protein; COG: COG0431 Predicted flavoprotein; Psort location: cytoplasmic, score: 23 YP_001572736.1 KEGG: ssn:SSO_3713 3.0e-06 yhhU; hypothetical protein K06133; COG: COG2091 Phosphopantetheinyl transferase; Psort location: cytoplasmic, score: 23 YP_001572737.1 Involved in anaerobic NO protection YP_001572738.1 Confers resistance to chloramphenicol YP_001572739.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001572740.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001572741.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001572742.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001572743.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001572744.1 binds the polymerase to DNA and acts as a sliding clamp YP_001572745.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001572746.1 negatively supercoils closed circular double-stranded DNA YP_001572747.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_001572748.1 Psort location: cytoplasmic, score: 23 YP_001572749.1 Psort location: cytoplasmic, score: 23 YP_001572750.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572751.1 COG: COG3501 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572752.1 Psort location: cytoplasmic, score: 23 YP_001572753.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide YP_001572754.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_001572755.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes YP_001572756.1 Psort location: cytoplasmic, score: 23 YP_001572757.1 KEGG: eci:UTI89_C2480 6.1e-45 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: nuclear, score: 23 YP_001572758.1 KEGG: stm:STM3822 0. torA; trimethylamine N-oxide reductase subunit K07811; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001572759.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor YP_001572760.1 KEGG: stm:STM3820 8.4e-254 putative cytochrome c peroxidase K00428; COG: COG1858 Cytochrome c peroxidase; Psort location: endoplasmic reticulum, score: 9 YP_001572761.1 ATP-binding protein; required for proper cytochrome c maturation YP_001572762.1 COG: COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001572763.1 KEGG: vfi:VF1822 1.3e-81 heme chaperone heme-lyase K02195; COG: COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001572764.1 COG: COG3114 Heme exporter protein D; Psort location: cytoplasmic, score: 23 YP_001572765.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001572766.1 KEGG: vfi:VF1819 3.1e-217 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: plasma membrane, score: 23 YP_001572767.1 KEGG: azo:azo3929 1.2e-30 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001572768.1 KEGG: stm:STM4281 1.6e-17 nrfE; putative methylase K04016; COG: COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; Psort location: endoplasmic reticulum, score: 9 YP_001572769.1 KEGG: eci:UTI89_C4240 7.9e-187 yidR; hypothetical protein YidR; COG: NOG06296 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572770.1 COG: COG5645 Predicted periplasmic lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001572771.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_001572772.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_001572773.1 Psort location: nuclear, score: 23 YP_001572774.1 Psort location: cytoplasmic, score: 23 YP_001572775.1 COG: COG2985 Predicted permease; Psort location: plasma membrane, score: 23 YP_001572776.1 KEGG: bha:BH0394 9.9e-09 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: endoplasmic reticulum, score: 9 YP_001572777.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function YP_001572778.1 KEGG: ecj:JW3654 9.1e-257 yidJ; predicted sulfatase/phosphatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572779.1 COG: NOG10263 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572780.1 KEGG: cal:orf19.201 9.1e-06 CDC47; DNA helicase and DNA replication licensing factor K02210; COG: COG2149 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572781.1 COG: NOG09782 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572782.1 COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: nuclear, score: 23 YP_001572783.1 catalyzes the formation of pyruvate from serine YP_001572784.1 KEGG: bja:blr3367 4.7e-07 probable cellulase K01179; COG: NOG14136 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572785.1 multidrug efflux protein involved in adaptation to low energy shock YP_001572786.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 23 YP_001572787.1 Psort location: cytoplasmic, score: 23 YP_001572788.1 COG: NOG22741 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572789.1 KEGG: spt:SPA3646 2.2e-294 ilvB; acetohydroxy acid synthase I, small subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: cytoplasmic, score: 23 YP_001572790.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit YP_001572791.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001572792.1 KEGG: stm:STM3793 5.3e-158 putative sugar kinase K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001572793.1 COG: COG0738 Fucose permease; Psort location: plasma membrane, score: 23 YP_001572794.1 COG: NOG07851 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572795.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter YP_001572796.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_001572797.1 membrane protein regulates uhpT expression YP_001572798.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_001572799.1 COG: NOG09018 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572800.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001572801.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001572802.1 Psort location: cytoplasmic, score: 23 YP_001572803.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001572804.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: nuclear, score: 23 YP_001572805.1 KEGG: mtu:Rv1811 3.7e-38 mgtC; possible Mg2+ transport P-type ATPase C MgtC K07507; COG: COG1285 Uncharacterized membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572806.1 KEGG: stm:STM3763 0. mgtB; Mg2+ transport protein K01531; COG: COG0474 Cation transport ATPase; Psort location: plasma membrane, score: 23 YP_001572807.1 Psort location: extracellular, including cell wall, score: 9 YP_001572808.1 COG: NOG12157 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572809.1 KEGG: sty:STY4832 0. Bacteriophage P4 DNA primase; COG: COG4643 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572810.1 COG: NOG29857 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572811.1 COG: NOG32339 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572812.1 Psort location: cytoplasmic, score: 23 YP_001572813.1 COG: NOG06294 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572814.1 COG: NOG20798 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572815.1 COG: COG3311 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572816.1 Psort location: cytoplasmic, score: 23 YP_001572817.1 COG: NOG23022 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572818.1 COG: NOG23021 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001572819.1 COG: NOG18557 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572820.1 KEGG: fnu:FN0161 3.7e-38 RNA-directed DNA polymerase K00986; COG: COG3344 Retron-type reverse transcriptase; Psort location: nuclear, score: 23 YP_001572821.1 Psort location: nuclear, score: 23 YP_001572822.1 Psort location: cytoplasmic, score: 23 YP_001572823.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001572824.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572825.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_001572826.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides YP_001572827.1 KEGG: sce:YIR019C 2.2e-29 MUC1; Required for invasion and pseudohyphae formation in response to nitrogen starvation K01178; COG: COG5295 Autotransporter adhesin; Psort location: mitochondrial, score: 23 YP_001572828.1 COG: NOG06061 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572829.1 KEGG: hpa:HPAG1_1114 0.00018 hypothetical protein K00760; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001572830.1 KEGG: bxe:Bxe_A4149 0.0087 cytochrome bd ubiquinol oxidase, subunit II K00426; COG: COG0786 Na+/glutamate symporter; Psort location: plasma membrane, score: 23 YP_001572831.1 catalyzes branch migration in Holliday junction intermediates YP_001572832.1 specifically modifies tRNA at position G18 YP_001572833.1 KEGG: spt:SPA3594 0. spoT; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; CG Site No. 156 K01139; COG: COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; Psort location: cytoplasmic, score: 23 YP_001572834.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001572835.1 Essential for recycling GMP and indirectly, cGMP YP_001572836.1 Psort location: nuclear, score: 23 YP_001572837.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_001572838.1 COG: COG2860 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572839.1 Psort location: cytoplasmic, score: 23 YP_001572840.1 KEGG: sus:Acid_6874 1.7e-42 beta-lactamase K01467; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: cytoplasmic, score: 23 YP_001572841.1 COG: NOG25608 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572842.1 COG: COG1561 Uncharacterized stress-induced protein; Psort location: cytoplasmic, score: 23 YP_001572843.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001572844.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001572845.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_001572846.1 catalyzes the formation of dUMP from dUTP YP_001572847.2 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001572848.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001572849.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001572850.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001572851.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001572852.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001572853.1 Psort location: endoplasmic reticulum, score: 9 YP_001572854.1 KEGG: sty:STY4071 8.9e-179 rfaQ, waaQ; lipopolysaccharide heptosyltransferase III K02849; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001572855.1 KEGG: stm:STM3722 2.5e-197 rfaG, waaG; UDP-glucose:(heptosyl)lipopolysaccharide alpha-1,3-glucosyltransferase K02844; COG: COG0438 Glycosyltransferase; Psort location: mitochondrial, score: 23 YP_001572856.1 KEGG: spt:SPA3573 1.2e-137 waaP; lipopolysaccharide core biosynthesis protein K02848; COG: NOG06227 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001572857.1 KEGG: pmu:PM0508 8.1e-27 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase K00785; COG: NOG15044 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572858.1 KEGG: sec:SC3642 3.5e-184 rfaB; UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase K02840; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001572859.1 KEGG: stt:t3801 1.1e-171 waaI; lipopolysaccharide 1,3-galactosyltransferase K03278; COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoplasmic, score: 23 YP_001572860.1 KEGG: stm:STM3717 1.8e-171 rfaJ, waaJ; UDP-D-glucose:(galactosyl)lipopolysaccharide alpha-1,2-glucosyltransferase K03279; COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoskeletal, score: 9 YP_001572861.1 KEGG: stt:t3803 1.6e-115 waaY; lipopolysaccharide core biosynthesis protein K02850; COG: NOG10262 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572862.1 COG: NOG06879 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572863.1 Psort location: cytoplasmic, score: 23 YP_001572864.1 KEGG: sec:SC3636 2.3e-203 waaL; hypothetical protein K02847; COG: COG3307 Lipid A core - O-antigen ligase and related enzymes; Psort location: plasma membrane, score: 23 YP_001572865.1 KEGG: stt:t3807 3.1e-169 waaC; lipopolysaccharide heptosyltransferase-1 K02841; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001572866.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_001572867.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_001572868.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001572869.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001572870.1 KEGG: sty:STY4088 8.1e-185 putative glycosyltransferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: extracellular, including cell wall, score: 23 YP_001572871.1 COG: COG2861 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001572872.1 KEGG: cya:CYA_1627 1.6e-28 peptidase, M23B family; COG: COG4942 Membrane-bound metallopeptidase; Psort location: nuclear, score: 23 YP_001572873.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001572874.1 KEGG: pha:PSHAa0367 2.2e-26 rhodanese sulfur transferase K01010; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001572875.1 KEGG: eci:UTI89_C4152 3.3e-37 grxC; glutaredoxin 3 K03676; COG: COG0695 Glutaredoxin and related proteins; Psort location: cytoplasmic, score: 23 YP_001572876.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001572877.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001572878.1 catalyzes the O-acetylation of serine YP_001572879.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572880.1 KEGG: stm:STM3697 6.7e-213 putative mandelate racemase / muconate lactonizing enzyme family K01781; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: mitochondrial, score: 23 YP_001572881.1 Psort location: nuclear, score: 23 YP_001572882.1 KEGG: efa:EF1922 7.3e-06 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572883.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_001572884.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_001572885.1 represses the lctPRD operon YP_001572886.1 COG: COG1620 L-lactate permease; Psort location: plasma membrane, score: 23 YP_001572887.1 COG: NOG10267 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572888.1 KEGG: eca:ECA2363 7.0e-05 DNA polymerase III, theta subunit K00961; COG: NOG18544 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572889.1 Acts as a repressor of the mtlAD operon YP_001572890.1 KEGG: sec:SC3610 8.6e-197 mtlD; mannitol-1-phosphate dehydrogenase K00009; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001572891.1 KEGG: stm:STM3685 0. mtlA; PTS family, mannitol-specific enzyme IIABC components K02798:K02799:K02800; COG: COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; Psort location: plasma membrane, score: 23 YP_001572892.1 KEGG: lpl:lp_1381 2.3e-29 astA; arylsulfate sulfotransferase K01023; COG: NOG14107 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572893.1 Psort location: cytoplasmic, score: 23 YP_001572894.1 KEGG: sav:SAV0242 6.4e-169 PTS enzyme K02790:K02791; COG: COG1264 Phosphotransferase system IIB components; Psort location: endoplasmic reticulum, score: 9 YP_001572895.1 KEGG: reh:H16_B1528 9.4e-24 sulfatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572896.1 KEGG: ldb:Ldb1268 6.5e-25 putative mutarotase K01785; COG: COG2017 Galactose mutarotase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001572897.1 KEGG: bam:Bamb_0825 1.1e-20 glucokinase K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572898.1 COG: COG2149 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572899.1 KEGG: sil:SPO2890 0.0075 glucans biosynthesis glucosyltransferase H, putative K03669; Psort location: endoplasmic reticulum, score: 9 YP_001572900.1 KEGG: eci:UTI89_C4134 8.9e-92 yibF; putative S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001572901.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001572902.1 KEGG: eci:UTI89_C4132 1.1e-281 selB; selenocysteine-specific elongation factor K03833; COG: COG3276 Selenocysteine-specific translation elongation factor; Psort location: cytoplasmic, score: 23 YP_001572903.1 KEGG: ecc:c4410 2.2e-184 yiaY; probable alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001572904.1 KEGG: fnu:FN1474 3.0e-36 N-acetylmannosamine kinase K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001572905.1 KEGG: spt:SPA3531 1.2e-277 aldB; aldehyde dehydrogenase B K00138; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001572906.1 KEGG: eci:UTI89_C4115 2.9e-63 ysaA, yiaI; putative electron transport protein YsaA K00122; COG: COG1142 Fe-S-cluster-containing hydrogenase components 2; Psort location: nuclear, score: 23 YP_001572907.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_001572908.1 KEGG: stm:STM3664 1.2e-41 malS; periplasmic alpha-amylase precursor K01176; COG: COG0366 Glycosidases; Psort location: extracellular, including cell wall, score: 9 YP_001572909.1 KEGG: lpl:lp_2645 0.00030 acm2; muramidase K01185; COG: COG2992 Uncharacterized FlgJ-related protein; Psort location: extracellular, including cell wall, score: 9 YP_001572910.1 KEGG: bcz:BCZK2914 1.4e-11 adaA; methylphosphotriester-DNA alkyltransferase K00567; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572911.1 Psort location: cytoplasmic, score: 23 YP_001572912.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001572913.1 KEGG: spt:SPA3511 6.6e-254 xylB; xylulose kinase K00854; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001572914.1 COG: COG4682 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572915.1 COG: COG3274 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001572916.1 COG: NOG10996 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572917.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001572918.1 Psort location: cytoplasmic, score: 23 YP_001572919.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001572920.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001572921.1 Psort location: cytoplasmic, score: 23 YP_001572922.1 Psort location: cytoplasmic, score: 23 YP_001572923.1 COG: COG4453 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001572924.1 KEGG: sat:SYN_02693 1.6e-12 acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001572925.1 COG: NOG09853 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572926.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001572927.1 COG: COG2944 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572928.1 COG: NOG06217 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572929.1 KEGG: sec:SC3578 5.5e-76 yiaE; 2-keto-D-gluconate reductase K00090; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001572930.1 KEGG: bxe:Bxe_A4171 4.6e-05 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: extracellular, including cell wall, score: 9 YP_001572931.1 KEGG: spt:SPA3496 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001572932.1 KEGG: sty:STY4159 8.0e-75 yiaC; putative acetyltransferase K03826; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001572933.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine YP_001572934.1 COG: COG5571 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion; Psort location: cytoplasmic, score: 23 YP_001572935.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_001572937.1 KEGG: shn:Shewana3_2650 5.4e-124 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001572938.1 transports peptides consisting of two or three amino acids YP_001572939.1 KEGG: bpm:BURPS1710b_A0449 5.3e-05 glycine betaine/L-proline ABC transporter, permease protein K02001; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001572940.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_001572941.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_001572942.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001572943.1 KEGG: saz:Sama_1242 6.5e-07 meTHIonine gamma-lyase K01761; COG: COG0626 CystaTHIonine beta-lyases/cystaTHIonine gamma-synthases; Psort location: cytoplasmic, score: 23 YP_001572944.1 Psort location: cytoplasmic, score: 23 YP_001572945.1 COG: NOG05994 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572946.1 COG: NOG15366 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572947.1 KEGG: vfi:VFA0886 3.2e-27 zinc metalloprotease; COG: NOG14695 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001572948.1 COG: NOG13865 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572949.1 COG: COG1192 ATPases involved in chromosome partitioning; Psort location: extracellular, including cell wall, score: 9 YP_001572950.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_001572951.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_001572952.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_001572953.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_001572954.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_001572955.1 involved in the transport of C4-dicarboxylates across the membrane YP_001572956.1 KEGG: eci:UTI89_C4059 5.0e-233 yhjJ; protein YhjJ precursor K01412; COG: COG0612 Predicted Zn-dependent peptidases; Psort location: extracellular, including cell wall, score: 9 YP_001572957.1 KEGG: stt:t3905 2.7e-154 kdgK; 2-dehydro-3-deoxygluconokinase K00874; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001572958.1 in Escherichia coli this protein is involved in flagellar function YP_001572959.1 COG: COG2982 Uncharacterized protein involved in outer membrane biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001572960.1 Psort location: mitochondrial, score: 23 YP_001572961.1 KEGG: cal:orf19.2425 7.5e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001572962.1 KEGG: eci:UTI89_C4054 5.4e-156 yhjD; hypothetical protein; COG: COG1295 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572963.1 Psort location: mitochondrial, score: 23 YP_001572964.1 KEGG: shn:Shewana3_3435 6.2e-12 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572965.1 KEGG: ava:Ava_2028 8.5e-16 two component transcriptional regulator, LuxR family; COG: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001572966.1 KEGG: bam:Bamb_4258 1.3e-10 lysozyme K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: cytoplasmic, score: 23 YP_001572967.1 COG: NOG26124 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001572968.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_001572969.1 KEGG: reh:H16_A3019 6.0e-15 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001572970.1 KEGG: lwe:lwe2018 2.1e-28 sugar isomerase domain protein; COG: COG2222 Predicted phosphosugar isomerases; Psort location: cytoplasmic, score: 23 YP_001572971.1 KEGG: eco:b3374 1.3e-28 frlD, yhfQ; fructoselysine 6-kinase K00924; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001572972.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001572973.1 KEGG: stm:STM3598 1.9e-176 putative L-asparaginase K01424; COG: COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D; Psort location: extracellular, including cell wall, score: 9 YP_001572974.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001572975.1 COG: COG2961 Protein involved in catabolism of external DNA; Psort location: cytoplasmic, score: 23 YP_001572976.1 KEGG: cgl:NCgl1145 7.4e-23 cgl1192; serine protease; COG: COG1404 Subtilisin-like serine proteases; Psort location: extracellular, including cell wall, score: 9 YP_001572977.1 KEGG: sec:SC3523 0. opdA; oligopeptidase A K01414; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001572978.1 predicted SAM-dependent methyltransferase YP_001572979.1 KEGG: pfo:Pfl_2451 6.6e-119 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885; COG: COG1252 NADH dehydrogenase, FAD-containing subunit; Psort location: cytoplasmic, score: 23 YP_001572980.1 KEGG: ama:AM656 3.2e-08 aminotransferase, class V K04487; COG: COG1959 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001572981.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function YP_001572982.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001572983.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001572984.1 COG: COG0306 Phosphate/sulphate permeases; Psort location: plasma membrane, score: 23 YP_001572985.1 KEGG: gox:GOX1717 3.0e-07 putative oxidoreductase K00100; COG: COG2081 Predicted flavoproteins; Psort location: cytoplasmic, score: 23 YP_001572986.1 Psort location: nuclear, score: 23 YP_001572987.1 Inhibits transcription at high concentrations of nickel YP_001572988.1 KEGG: sty:STY4228 4.2e-94 4'-phosphopantetheinyl transferase K06133; COG: COG2091 Phosphopantetheinyl transferase; Psort location: cytoplasmic, score: 23 YP_001572989.1 KEGG: tbd:Tbd_2668 4.3e-11 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: plasma membrane, score: 23 YP_001572990.1 COG: NOG07879 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001572991.1 COG: COG1738 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001572992.1 COG: COG0425 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001572993.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_001572994.1 COG: COG3714 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572995.1 COG: NOG09778 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001572996.1 COG: COG3776 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001572997.1 catalyzes the methylation of 16S rRNA at position G966 YP_001572998.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_001572999.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_001573000.1 putative ABC transporter, membrane protein YP_001573001.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001573002.1 KEGG: ava:Ava_2791 0.0046 serine/threonine protein kinase K00903; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001573003.1 KEGG: reh:H16_B0069 7.0e-05 acetyltransferase K00680; COG: NOG09777 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573004.1 KEGG: aci:ACIAD3368 0.00051 mraW; S-adenosylmeTHIonine methyltransferase K03438; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001573005.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_001573006.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001573007.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001573008.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001573009.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_001573010.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_001573011.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_001573012.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_001573013.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_001573014.1 KEGG: cal:orf19.1526 6.5e-05 SNF2; component of SWI/SNF global transcription activator complex K01509; COG: NOG08680 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573015.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_001573016.1 KEGG: eco:b3440 5.8e-175 yhhX; predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001573017.1 KEGG: shn:Shewana3_3385 2.6e-13 hypoxanTHIne phosphoribosyltransferase K00760; COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001573018.1 KEGG: efa:EF1922 1.7e-07 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001573019.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_001573020.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001573021.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001573022.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_001573023.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001573024.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001573025.1 KEGG: spt:SPA3385 0. glgP; glycogen phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001573026.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001573027.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_001573028.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_001573029.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_001573030.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_001573031.1 KEGG: stm:STM3514 0. malP; maltodextrin phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001573032.1 amylomaltase; acts to release glucose from maltodextrins YP_001573033.1 KEGG: eci:UTI89_C3106 1.8e-68 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001573034.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_001573035.1 involved in high-affinity gluconate transport YP_001573036.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis YP_001573037.1 COG: COG5464 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001573038.1 COG: COG5464 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573039.1 COG: NOG13904 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001573040.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_001573041.1 COG: COG1918 Fe2+ transport system protein A; Psort location: cytoplasmic, score: 23 YP_001573042.1 KEGG: bur:Bcep18194_A5099 1.6e-245 RNA binding S1; COG: COG2183 Transcriptional accessory protein; Psort location: cytoplasmic, score: 23 YP_001573043.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001573044.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_001573045.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_001573046.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001573047.1 COG: NOG06297 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001573048.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001573049.1 COG: COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); Psort location: nuclear, score: 23 YP_001573050.1 KEGG: rso:RSc2880 5.8e-06 gph, RS00222; probable phosphoglycolate phosphatase protein K01091; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001573051.1 COG: NOG06324 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001573052.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001573053.2 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_001573054.1 COG: NOG05966 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573055.1 COG: COG3166 Tfp pilus assembly protein PilN; Psort location: golgi, score: 9 YP_001573056.1 COG: NOG13913 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001573057.1 COG: NOG12171 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573058.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_001573059.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001573060.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001573061.1 KEGG: cal:orf19.1327 7.5e-07 RBT1; repressed by Tup1, related to HWP1 K01186; COG: COG3266 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001573062.1 KEGG: stm:STM3484 3.4e-147 dam; DNA adenine methylase K06223; COG: COG0338 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001573063.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001573064.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001573065.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001573066.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_001573067.1 member of the FNT family of formate and nitrite transporters YP_001573068.1 Psort location: nuclear, score: 23 YP_001573069.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_001573070.1 KEGG: stm:STM3474 0. nirB; nitrite reductase, large subunit K00362; COG: COG1251 NAD(P)H-nitrite reductase; Psort location: cytoplasmic, score: 23 YP_001573071.1 Psort location: cytoplasmic, score: 23 YP_001573072.1 Psort location: mitochondrial, score: 23 YP_001573073.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001573074.1 KEGG: stm:STM3472 7.3e-97 ppiA; peptidyl-prolyl cis-trans isomerase A (rotamase A) K03767; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: extracellular, including cell wall, score: 9 YP_001573075.1 COG: NOG18128 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001573076.1 COG: COG2184 Protein involved in cell division; Psort location: cytoplasmic, score: 23 YP_001573077.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_001573078.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_001573079.1 KEGG: ssn:SSO_3489 0. yhfK; hypothetical protein K01823; COG: COG1289 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573080.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_001573081.1 COG: COG1765 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001573082.1 KEGG: spt:SPA3330 3.9e-153 prkB; phosphoribulokinase K00855; COG: COG3954 Phosphoribulokinase; Psort location: cytoplasmic, score: 23 YP_001573083.1 COG: COG3089 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573084.1 COG: COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold; Psort location: cytoplasmic, score: 23 YP_001573085.1 COG: NOG16906 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573086.1 Psort location: cytoplasmic, score: 23 YP_001573087.1 Psort location: cytoplasmic, score: 23 YP_001573088.1 KEGG: reh:H16_A2718 0.00020 pct; propionate CoA-transferase K01026; COG: NOG05983 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573089.1 KEGG: pfl:PFL_5819 2.2e-72 citG; triphosphoribosyl-dephosphocoenzyme-A synthase; COG: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; Psort location: cytoplasmic, score: 23 YP_001573090.1 COG: NOG17082 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573091.1 The beta subunit catalyzes the decarboxylation of the malonyl moiety on coenzyme A YP_001573092.1 KEGG: tko:TK1622 0.0014 methylmalonyl-CoA decarboxylase, alpha subunit K01604; COG: NOG08721 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573093.1 KEGG: azo:azo2534 1.8e-18 mdcF2; putative malonate transporter; COG: COG0679 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001573094.1 Catalyzes the transfer of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-acyl carrier protein of malonate dehydrogenase to form holo-acyl carrier protein YP_001573095.1 KEGG: pfo:Pfl_5296 5.1e-73 acyl transferase region K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: cytoplasmic, score: 23 YP_001573096.1 KEGG: shn:Shewana3_3435 1.4e-06 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001573097.1 KEGG: pen:PSEEN0163 3.1e-185 ABC transporter, ATP-binding protein; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: nuclear, score: 23 YP_001573098.1 required for KefB activity YP_001573099.1 involved in potassium efflux YP_001573100.1 KEGG: sto:ST1472 0.0027 DNA-directed RNA polymerase subunit M K03057; COG: COG3529 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain; Psort location: cytoplasmic, score: 23 YP_001573101.1 Psort location: endoplasmic reticulum, score: 23 YP_001573102.1 rotamase YP_001573103.1 COG: COG2900 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001573104.1 rotamase YP_001573105.1 COG: COG2964 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573106.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001573107.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001573108.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001573110.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001573111.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001573112.1 Psort location: cytoplasmic, score: 23 YP_001573113.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001573114.1 Psort location: nuclear, score: 23 YP_001573115.1 iron storage protein YP_001573116.1 KEGG: sec:SC3376 3.7e-102 hopD; leader peptidase HopD K02506; COG: COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; Psort location: endoplasmic reticulum, score: 9 YP_001573117.1 COG: COG0051 Ribosomal protein S10; Psort location: cytoplasmic, score: 23 YP_001573118.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001573119.1 Psort location: extracellular, including cell wall, score: 9 YP_001573120.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001573121.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001573123.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001573124.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001573125.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001573126.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001573127.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001573128.1 one of the stabilizing components for the large ribosomal subunit YP_001573129.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001573130.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001573131.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001573132.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001573133.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001573134.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001573135.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001573136.1 binds 5S rRNA along with protein L5 and L25 YP_001573138.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001573139.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001573140.1 late assembly protein YP_001573141.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001573142.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001573143.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001573144.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001573145.1 COG: COG0203 Ribosomal protein L17; Psort location: cytoplasmic, score: 23 YP_001573146.1 COG: NOG18395 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001573147.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_001573148.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001573149.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001573150.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_001573151.1 KEGG: sec:SC3343 6.2e-139 fmt; 10-formyltetrahydrofolate:L-meTHIonyl-tRNA(fMet) N-formyltransferase K00604; COG: COG0223 MeTHIonyl-tRNA formyltransferase; Psort location: cytoplasmic, score: 23 YP_001573152.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001573153.1 COG: COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; Psort location: cytoplasmic, score: 23 YP_001573154.1 COG: COG2922 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573155.1 KEGG: cvi:CV4269 1.8e-43 topA; DNA topoisomerase K03168; COG: COG0551 Zn-finger domain associated with topoisomerase type I; Psort location: nuclear, score: 23 YP_001573156.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_001573157.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001573158.1 COG: NOG13911 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573159.1 KEGG: eci:UTI89_C3724 5.4e-85 yrdA; protein YrdA K00680; COG: COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; Psort location: cytoplasmic, score: 23 YP_001573161.1 Psort location: cytoplasmic, score: 23 YP_001573162.1 Psort location: cytoplasmic, score: 23 YP_001573163.1 KEGG: eci:UTI89_C2351 3.8e-107 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001573164.1 COG: COG0845 Membrane-fusion protein; Psort location: mitochondrial, score: 23 YP_001573165.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001573166.1 KEGG: shn:Shewana3_3829 0.00012 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: cytoplasmic, score: 23 YP_001573167.1 KEGG: syn:slr2098 4.8e-13 hik21; two-component hybrid histidine kinase K07678; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001573168.1 COG: NOG13902 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001573169.1 KEGG: sty:STY3566 1.6e-149 yhdJ; putative adenine-specific DNA-modification methylase K07319; COG: COG0863 DNA modification methylase; Psort location: nuclear, score: 23 YP_001573170.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001573171.1 KEGG: sec:SC3322 8.2e-169 yhdG, nifR3; putative TIM-barrel enzyme, possibly dehydrogenase K05540; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001573172.1 Psort location: cytoplasmic, score: 23 YP_001573173.1 KEGG: eca:ECA0257 6.2e-36 cah; carbonic anhydrase K01674; COG: COG3338 Carbonic anhydrase; Psort location: extracellular, including cell wall, score: 9 YP_001573174.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001573175.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_001573176.1 COG: COG3924 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573177.1 COG: NOG04153 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573178.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001573179.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001573180.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001573181.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001573182.1 KEGG: eci:UTI89_C3684 5.3e-149 yhdH; protein YhdH K00001; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: endoplasmic reticulum, score: 9 YP_001573183.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_001573184.1 functions in MreBCD complex in some organisms YP_001573185.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001573186.1 part of cell wall structural complex MreBCD; transmembrane component YP_001573187.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001573188.1 involved in the processing of the 5'end of 16S rRNA YP_001573189.1 COG: COG3164 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573190.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_001573191.1 KEGG: shn:Shewana3_3435 4.3e-09 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001573192.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_001573193.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001573194.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001573195.1 COG: COG2732 Barstar, RNAse (barnase) inhibitor; Psort location: cytoplasmic, score: 23 YP_001573196.1 COG: NOG30709 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573197.1 COG: NOG12178 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573198.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001573199.1 oxidizes malate to oxaloacetate YP_001573200.1 KEGG: sty:STY3529 1.2e-181 degS; serine protease K04691; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: endoplasmic reticulum, score: 9 YP_001573201.1 KEGG: spt:SPA3215 5.4e-227 degQ; serine protease K04772; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: extracellular, including cell wall, score: 9 YP_001573202.1 KEGG: eco:b3233 8.4e-64 yhcB; hypothetical protein K00424; COG: COG3105 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001573203.1 KEGG: reh:H16_A2322 7.0e-76 ATPase K01529; COG: COG1485 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001573204.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001573205.1 forms a direct contact with the tRNA during translation YP_001573206.1 Psort location: nuclear, score: 23 YP_001573207.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_001573208.1 COG: COG2969 Stringent starvation protein B; Psort location: cytoplasmic, score: 23 YP_001573209.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_001573210.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_001573211.1 KEGG: cal:orf19.6141 5.3e-05 HXT1; high-affinity hexose (glucose) transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001573212.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001573213.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_001573214.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001573215.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_001573216.1 KEGG: pae:PA2649 0.0024 nuoN; NADH dehydrogenase I chain N K00343; COG: COG1457 Purine-cytosine permease and related proteins; Psort location: plasma membrane, score: 23 YP_001573217.1 COG: COG4804 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001573218.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001573219.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_001573220.1 KEGG: eci:UTI89_C3647 5.3e-149 yhcC; hypothetical protein; COG: COG1242 Predicted Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001573221.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_001573222.1 KEGG: gvi:glr2813 0.00078 probable protease K05520; COG: COG3155 Uncharacterized protein involved in an early stage of isoprenoid biosynthesis; Psort location: extracellular, including cell wall, score: 9 YP_001573223.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001573224.1 COG: NOG06212 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573225.1 KEGG: aha:AHA_3919 4.7e-31 multiphosphoryl transfer protein (MTP) K00924; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001573226.1 KEGG: reh:H16_A0381 1.9e-59 predicted P-loop-containing kinase K01009; COG: COG1660 Predicted P-loop-containing kinase; Psort location: cytoplasmic, score: 23 YP_001573227.1 KEGG: stm:STM3322 1.5e-80 ptsN; sugar specific PTS family, enzyme IIA, also regulates N metabolism K02806; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001573228.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_001573229.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_001573230.1 KEGG: pen:PSEEN1094 1.6e-83 ABC transporter, ATP-binding protein; COG: COG1137 ABC-type (unclassified) transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001573231.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_001573232.1 COG: COG3117 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001573233.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_001573234.1 KEGG: stm:STM3315 2.4e-169 yrbH; putative sugar phosphate isomerase K06041; COG: COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Psort location: cytoplasmic, score: 23 YP_001573235.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_001573236.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_001573237.1 COG: COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001573238.1 COG: COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001573239.1 COG: COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; Psort location: extracellular, including cell wall, score: 9 YP_001573240.1 COG: COG3113 Predicted NTP binding protein (contains STAS domain); Psort location: cytoplasmic, score: 23 YP_001573241.1 COG: COG5007 Predicted transcriptional regulator, BolA superfamily; Psort location: cytoplasmic, score: 23 YP_001573242.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001573243.1 activator of maltose metabolism genes YP_001573244.1 KEGG: sec:SC3243 6.4e-201 ispB; octaprenyl diphosphate synthase K02523; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: cytoplasmic, score: 23 YP_001573245.1 involved in the peptidyltransferase reaction during translation YP_001573246.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001573247.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001573248.1 Psort location: nuclear, score: 23 YP_001573249.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001573250.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001573251.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_001573252.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_001573253.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_001573254.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_001573255.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001573256.1 KEGG: lpn:lpg1509 0.0036 D-alanyl-D-alanine carboxypeptidase K07258; COG: COG1314 Preprotein translocase subunit SecG; Psort location: endoplasmic reticulum, score: 9 YP_001573257.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_001573258.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001573259.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001573260.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001573261.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001573262.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001573263.1 KEGG: sec:SC3223 0. pnp; polynucleotide phosphorylase, member of mRNA degradosome K00962; COG: COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); Psort location: cytoplasmic, score: 23 YP_001573264.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_001573265.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_001573266.1 tryptophan transporter of high affinity YP_001573267.1 KEGG: eci:UTI89_C3587 3.2e-167 yhbW; hypothetical protein K00494; COG: COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001573268.1 KEGG: eci:UTI89_C3586 7.6e-150 yhbV; hypothetical protein YhbV K01423; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001573269.1 KEGG: stm:STM3274 2.4e-176 yhbU; putative protease K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001573270.1 COG: COG3154 Putative lipid carrier protein; Psort location: cytoplasmic, score: 23 YP_001573271.1 KEGG: sec:SC3213 1.4e-86 yhbS; putative ABC superfamily (membrane) transport protein K03824; COG: COG3153 Predicted acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001573272.1 COG: COG2827 Predicted endonuclease containing a URI domain; Psort location: cytoplasmic, score: 23 YP_001573273.1 COG: COG3787 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573274.1 KEGG: spt:SPA3138 6.7e-87 yhbO; hypothetical protein K05520; COG: COG0693 Putative intracellular protease/amidase; Psort location: cytoplasmic, score: 23 YP_001573275.1 KEGG: ccr:CC3604 7.8e-11 NADH-ubiquinone oxidoreductase 39 kDa subunit precursor, putative K00329:K00356; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: mitochondrial, score: 23 YP_001573276.1 COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001573277.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_001573278.1 KEGG: eci:UTI89_C3574 1.2e-55 yraN; hypothetical protein YraN K07460; COG: COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001573279.1 COG: COG3107 Putative lipoprotein; Psort location: nuclear, score: 23 YP_001573280.1 KEGG: eci:UTI89_C3573 1.2e-142 yraL; hypothetical protein; COG: COG0313 Predicted methyltransferases; Psort location: cytoplasmic, score: 23 YP_001573281.1 Psort location: mitochondrial, score: 23 YP_001573282.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_001573283.1 KEGG: ecc:c3893 1.7e-175 agaS; putative tagatose-6-phosphate ketose/aldose isomerase K02082; COG: COG2222 Predicted phosphosugar isomerases; Psort location: cytoplasmic, score: 23 YP_001573284.1 KEGG: ece:Z4489 4.2e-172 putative N-acetylgalctosamine-6-phosphate deacetylase K02079; COG: COG1820 N-acetylglucosamine-6-phosphate deacetylase; Psort location: cytoplasmic, score: 23 YP_001573285.1 KEGG: eci:UTI89_C3561 2.4e-201 agaZ; putative tagatose 6-phosphate kinase 2 K00917; COG: COG4573 Predicted tagatose 6-phosphate kinase; Psort location: cytoplasmic, score: 23 YP_001573286.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons YP_001573287.1 KEGG: stm:STM3250 2.2e-278 garD; galactarate dehydrogenase K01708; COG: COG2721 Altronate dehydratase; Psort location: cytoplasmic, score: 23 YP_001573288.1 Psort location: cytoplasmic, score: 23 YP_001573289.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_001573290.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_001573291.1 KEGG: stm:STM3247 1.3e-191 garK; glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001573292.1 Psort location: cytoplasmic, score: 23 YP_001573293.1 Psort location: cytoplasmic, score: 23 YP_001573294.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_001573295.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_001573296.1 involved in the import of threonine and serine in combination with the import of a proton YP_001573297.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_001573298.1 KEGG: stm:STM3241 0. tdcE; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001573299.1 KEGG: spt:SPA3109 1.4e-230 tdcG; L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001573300.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001573301.1 COG: COG3681 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573302.1 COG: NOG18539 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001573303.1 COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001573304.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001573305.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573306.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001573307.1 KEGG: nwi:Nwi_1143 0.00018 helix-turn-helix, fis-type K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001573308.1 Psort location: nuclear, score: 23 YP_001573309.1 Psort location: extracellular, including cell wall, score: 9 YP_001573310.1 KEGG: syf:Synpcc7942_1085 0.00069 1,4-alpha-glucan branching enzyme K00700; COG: COG3409 Putative peptidoglycan-binding domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001573311.1 KEGG: nwi:Nwi_0782 2.4e-11 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001573312.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23; ORF located using Blastx YP_001573313.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001573314.1 KEGG: lpn:lpg0671 0.0076 ndh; NADH dehydrogenase transmembrane protein K03885; COG: COG2259 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573315.1 Psort location: nuclear, score: 23 YP_001573316.1 COG: NOG11454 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573317.1 COG: COG5393 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573318.1 COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573319.1 KEGG: bli:BL03996 7.8e-05 atpF; ATP synthase (subunit b) K02109; COG: NOG17164 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573320.1 COG: NOG09774 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573321.1 KEGG: sab:SAB2386 1.6e-10 probable alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001573322.1 COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001573323.1 involved in the import of serine and threonine coupled with the import of sodium YP_001573324.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001573325.1 KEGG: ecc:c3845 1.5e-146 ygjR; hypothetical oxidoreductase YgjR; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001573326.1 COG: COG1451 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001573327.1 KEGG: stm:STM3220 1.2e-201 ygjO; putative ribosomal RNA small subunit methyltransferase D K00564; COG: COG2813 16S RNA G1207 methylase RsmC; Psort location: cytoplasmic, score: 23 YP_001573328.1 KEGG: stm:STM3219 0. fadH; 2,4-dieonyl-CoA reductase K00219; COG: COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001573329.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_001573330.1 Psort location: cytoplasmic, score: 23 YP_001573331.1 KEGG: azo:azo3685 6.7e-13 putative hybrid sensor and regulator protein; COG: COG2202 FOG: PAS/PAC domain; Psort location: endoplasmic reticulum, score: 9 YP_001573332.1 KEGG: abo:ABO_1307 4.7e-09 sensor histidine kinase/respose regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001573333.1 COG: COG1695 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001573334.1 Psort location: cytoplasmic, score: 23 YP_001573335.1 COG: COG2375 Siderophore-interacting protein; Psort location: cytoplasmic, score: 23 YP_001573336.1 KEGG: sty:STY3391 4.1e-87 mug; G/U mismatch-specific DNA glycosylase K03649; COG: COG3663 G:T/U mismatch-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001573337.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001573338.1 synthesizes RNA primers at the replication forks YP_001573339.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001573340.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001573341.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001573342.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin YP_001573343.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001573344.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_001573345.1 KEGG: bsu:BG13806 0.0074 yrvJ; N-acetylmuramoyl-L-alanine amidase, peptidoglycan hydrolase, LytC amidase family K01448; COG: COG3103 SH3 domain protein; Psort location: extracellular, including cell wall, score: 23 YP_001573346.1 KEGG: aha:AHA_3770 3.3e-37 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573347.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001573348.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001573349.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_001573350.1 COG: COG2960 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001573351.1 DHBP synthase; functions during riboflavin biosynthesis YP_001573352.1 KEGG: cps:CPS_3513 2.3e-15 dsbB; disulfide bond formation protein B K03611; COG: COG1495 Disulfide bond formation protein DsbB; Psort location: endoplasmic reticulum, score: 9 YP_001573353.1 KEGG: bci:BCI_0257 2.8e-10 dsbA; THIol:disulfide interchange protein DsbA K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001573354.1 KEGG: eci:UTI89_C3473 3.1e-295 assT; arylsulfate sulfotransferase K01023; COG: NOG06306 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573355.1 Psort location: cytoplasmic, score: 23 YP_001573356.1 COG: COG0428 Predicted divalent heavy-metal cations transporter; Psort location: plasma membrane, score: 23 YP_001573357.1 Psort location: cytoplasmic, score: 23 YP_001573358.1 KEGG: vvy:VV2267 1.7e-122 glutaTHIonylspermidine synthase K01917; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoplasmic, score: 23 YP_001573359.1 COG: COG5463 Predicted integral membrane protein; Psort location: nuclear, score: 23 YP_001573360.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_001573361.1 KEGG: sec:SC3129 2.1e-83 yqiE; putative resistance protein K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001573362.1 COG: COG3151 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573363.1 KEGG: eci:UTI89_C3466 4.5e-136 icc; icc protein K03651; COG: COG1409 Predicted phosphohydrolases; Psort location: cytoplasmic, score: 23 YP_001573364.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001573365.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001573366.1 COG: COG1359 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573367.1 KEGG: eci:UTI89_C3455 7.3e-97 mdaB; modulator of drug activity B K03923; COG: COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); Psort location: cytoplasmic, score: 23 YP_001573368.1 KEGG: sec:SC3122 6.5e-231 ygiY; putative sensory histidine kinase in regulatory system K07645; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001573369.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_001573370.1 COG: COG3111 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001573371.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001573372.1 KEGG: sty:STY3350 9.3e-129 plsC; 1-acyl-glycerol-3-phosphate acyltransferase K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: endoplasmic reticulum, score: 9 YP_001573373.1 KEGG: eci:UTI89_C3443 1.1e-244 sufI; FtsI suppressor K04753; COG: COG2132 Putative multicopper oxidases; Psort location: cytoplasmic, score: 23 YP_001573374.1 KEGG: eci:UTI89_C3435 0. hypothetical protein; COG: COG1032 Fe-S oxidoreductase; Psort location: nuclear, score: 23 YP_001573375.1 KEGG: reh:H16_A0281 1.1e-13 diadenosine tetraphosphate (Ap4A) hydrolase K01518; COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: cytoplasmic, score: 23 YP_001573376.1 KEGG: fnu:FN2030 0.00017 inorganic pyrophosphatase K01507; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001573377.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_001573378.1 KEGG: spt:SPA3032 1.9e-201 yqhD; probable alcohol dehydrogenase K08325; COG: COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; Psort location: cytoplasmic, score: 23 YP_001573379.1 KEGG: bli:BL05281 3.0e-07 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001573380.1 KEGG: lsl:LSL_1322 1.0e-08 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001573381.1 catalyzes the formation of L-homocysteine from cystathionine YP_001573382.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001573383.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001573384.1 KEGG: sec:SC3099 2.4e-153 yghA; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001573385.1 COG: NOG30084 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001573386.1 COG: NOG27696 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001573387.1 Psort location: endoplasmic reticulum, score: 9 YP_001573388.1 COG: COG2862 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573389.1 KEGG: abo:ABO_1307 1.8e-06 sensor histidine kinase/respose regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001573390.1 COG: NOG11338 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573391.1 involved in hydrogen uptake YP_001573392.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_001573393.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_001573394.1 involved in hydrogen uptake YP_001573395.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_001573396.1 COG: NOG08099 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573397.1 plays a role in hydrogenase nickel cofactor insertion YP_001573398.1 COG: COG0298 Hydrogenase maturation factor; Psort location: endoplasmic reticulum, score: 9 YP_001573399.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_001573400.1 KEGG: stt:t3060 8.6e-284 gsp; glutaTHIonylspermidine synthetase/amidase K01460:K01917; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoplasmic, score: 23 YP_001573401.1 Psort location: cytoplasmic, score: 23 YP_001573402.1 COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: nuclear, score: 23 YP_001573403.1 KEGG: blo:BL1457 0.0097 gcp; metalloendopeptidase Gcp K01409; Psort location: mitochondrial, score: 23 YP_001573404.1 Psort location: cytoplasmic, score: 23 YP_001573405.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001573406.1 KEGG: stt:t3057 1.1e-260 uxuB; D-mannonate oxidoreductase K00040; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001573407.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001573408.1 Psort location: cytoplasmic, score: 23 YP_001573409.1 Psort location: cytoplasmic, score: 23 YP_001573410.1 Psort location: nuclear, score: 23 YP_001573411.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001573412.1 Psort location: cytoplasmic, score: 23 YP_001573413.1 KEGG: rha:RHA1_ro03918 1.5e-13 probable formamidase K01455; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001573414.1 KEGG: hpa:HPAG1_0312 1.2e-50 hypothetical protein K01463; COG: COG0726 Predicted xylanase/chitin deacetylase; Psort location: cytoplasmic, score: 23 YP_001573415.1 Psort location: nuclear, score: 23 YP_001573416.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: nuclear, score: 23 YP_001573417.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS YP_001573418.1 KEGG: stm:STM3129 1.2e-247 putative NAD-dependent aldehyde dehydrogenase K00146; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001573419.1 KEGG: sty:STY3297 2.2e-230 ordL; putative oxidoreductase; COG: COG0665 Glycine/D-amino acid oxidases (deaminating); Psort location: cytoplasmic, score: 23 YP_001573420.1 COG: COG3450 Predicted enzyme of the cupin superfamily; Psort location: cytoplasmic, score: 23 YP_001573421.1 KEGG: eci:UTI89_C0120 8.0e-05 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001573422.1 COG: NOG18538 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573423.1 KEGG: eci:UTI89_C1417 1.1e-05 narL; NarL transcriptional dual regulator K07684; COG: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001573424.1 KEGG: syg:sync_2368 9.3e-22 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001573425.1 KEGG: stm:STM3122 0. putative arylsulfatase K01130; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: extracellular, including cell wall, score: 9 YP_001573426.1 KEGG: shn:Shewana3_3435 3.3e-21 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001573427.1 KEGG: sec:SC3060 5.9e-127 cilB; putative transcriptional regulator, LysR family K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: cytoplasmic, score: 23 YP_001573428.1 KEGG: nph:NP4248A 4.1e-23 fadB_1; enoyl-CoA hydratase II 1 K01692; COG: COG2030 Acyl dehydratase; Psort location: cytoplasmic, score: 23 YP_001573429.1 KEGG: azo:azo3544 2.1e-76 probable 4-hydroxybutyrate coenzyme A transferase K01041; COG: COG0427 Acetyl-CoA hydrolase; Psort location: cytoplasmic, score: 23 YP_001573430.1 Psort location: cytoplasmic, score: 23 YP_001573431.1 Psort location: endoplasmic reticulum, score: 9 YP_001573432.1 COG: COG3209 Rhs family protein; Psort location: nuclear, score: 23 YP_001573433.1 Psort location: cytoplasmic, score: 23 YP_001573434.1 Psort location: cytoplasmic, score: 23 YP_001573435.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001573436.1 Psort location: vesicles of secretory system, score: 9 YP_001573437.1 COG: NOG27449 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573438.1 Psort location: nuclear, score: 23 YP_001573439.1 Psort location: cytoplasmic, score: 23 YP_001573440.1 COG: COG2336 Growth regulator; Psort location: cytoplasmic, score: 23 YP_001573441.1 COG: COG2337 Growth inhibitor; Psort location: cytoplasmic, score: 23 YP_001573442.1 COG: NOG29953 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573443.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001573444.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001573445.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001573446.1 COG: COG1811 Uncharacterized membrane protein, possible Na+ channel or pump; Psort location: plasma membrane, score: 23 YP_001573447.1 KEGG: stm:STM3114 0. speC; orniTHIne decarboxylase isozyme K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001573448.1 KEGG: eci:UTI89_C3355 3.2e-206 nupG; transport of nucleosides, permease protein K03289; COG: NOG06211 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001573449.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001573450.1 KEGG: dps:DP2952 0.0096 probable fumarate hydratase class I, anaerobic K01676; COG: COG2924 Fe-S cluster protector protein; Psort location: cytoplasmic, score: 23 YP_001573451.1 KEGG: spt:SPA2973 1.1e-191 mutY; A/G-specific adenine glycosylase K03575; COG: COG1194 A/G-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001573452.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001573453.1 COG: COG3171 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001573454.1 COG: NOG06291 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573455.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_001573456.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001573457.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001573458.1 COG: COG1872 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573459.1 COG: COG0762 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573460.1 KEGG: eci:UTI89_C3340 3.5e-106 yggS; hypothetical protein; COG: COG0325 Predicted enzyme with a TIM-barrel fold; Psort location: cytoplasmic, score: 23 YP_001573461.1 KEGG: pen:PSEEN2333 2.2e-25 xcpR-2; type II secretion pathway protein E K01509; COG: COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT; Psort location: cytoplasmic, score: 23 YP_001573462.1 COG: COG1414 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001573463.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001573464.1 COG: COG1678 Putative transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001573465.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001573466.1 COG: COG1385 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573467.1 KEGG: spt:SPA2956 2.1e-129 endA; endonuclease I K01150; COG: COG2356 Endonuclease I; Psort location: cytoplasmic, score: 23 YP_001573468.1 COG: COG3091 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001573469.1 KEGG: cal:orf19.3526 6.0e-54 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001573470.1 Psort location: mitochondrial, score: 23 YP_001573471.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001573472.1 Psort location: cytoplasmic, score: 23 YP_001573473.1 COG: NOG20647 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573474.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_001573475.1 catalyzes the formation of putrescine from agmatine YP_001573476.1 KEGG: stt:t2997 1.6e-126 putative metalloprotease K07387; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: extracellular, including cell wall, score: 9 YP_001573477.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001573478.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein YP_001573479.1 KEGG: eco:b2933 1.6e-220 cmtA, G527, cmt, tolM; PTS family enzyme IICB, mannitol-specific, cryptic K02799:K02800; COG: COG2213 Phosphotransferase system, mannitol-specific IIBC component; Psort location: endoplasmic reticulum, score: 9 YP_001573480.1 KEGG: vfi:VFA0062 5.2e-151 L-sorbose 1-phosphate reductase K00100; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001573481.1 KEGG: eca:ECA4268 2.1e-90 glpX; fructose-1,6-bisphosphatase II/sedoheptulose-1,7-bisphosphatase K02446; COG: COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins; Psort location: cytoplasmic, score: 23 YP_001573482.1 COG: COG3722 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001573483.1 KEGG: eci:UTI89_C3316 1.7e-88 yggC; hypothetical protein YggC K00867; COG: COG1072 Panthothenate kinase; Psort location: cytoplasmic, score: 23 YP_001573484.1 KEGG: bxe:Bxe_B2703 1.2e-27 ABC spermidine/putrescine family transporter, ATPase subunit K02052; COG: COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001573485.1 KEGG: reh:H16_A3086 1.2e-18 ABC-type transporter, ATPase component; COG: COG1122 ABC-type cobalt transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001573486.1 COG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: mitochondrial, score: 23 YP_001573487.1 COG: NOG07916 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001573488.1 KEGG: cya:CYA_1151 7.2e-23 glmU; UDP-N-acetylglucosamine pyrophosphorylase K04042:K00972; COG: COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif; Psort location: cytoplasmic, score: 23 YP_001573489.1 Psort location: mitochondrial, score: 23 YP_001573490.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_001573491.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001573492.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001573493.1 participates in the regulation of osmotic pressure changes within the cel YP_001573494.1 Involved in the export of arginine YP_001573495.1 COG: COG2968 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573496.1 KEGG: shn:Shewana3_3435 6.4e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoskeletal, score: 9 YP_001573497.1 KEGG: ssn:SSO_3071 5.5e-234 ygfH; putative coenzyme A transferase K01041; COG: COG0427 Acetyl-CoA hydrolase; Psort location: cytoplasmic, score: 23 YP_001573498.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA YP_001573499.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_001573500.1 MDM; functions in conversion of succinate to propionate YP_001573501.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001573502.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001573503.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001573504.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_001573505.1 KEGG: shn:Shewana3_3505 4.1e-16 fructose-bisphosphatase K01086; COG: COG3027 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001573506.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_001573507.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_001573508.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001573509.1 KEGG: ssn:SSO_3059 3.0e-187 visC; hypothetical protein; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001573510.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001573511.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001573512.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001573513.1 KEGG: stm:STM3051 5.5e-266 bglA; 6-phospho-beta-glucosidase A K01223; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001573514.1 COG: COG3097 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573515.1 COG: COG1272 Predicted membrane protein, hemolysin III homolog; Psort location: plasma membrane, score: 23 YP_001573516.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_001573517.1 COG: COG2938 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001573518.1 COG: NOG09016 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573519.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_001573520.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001573521.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_001573522.1 5'-3' single-stranded-DNA-specific exonuclease YP_001573523.1 KEGG: reh:H16_A1169 1.1e-107 prfB; protein chain release factor B (RF-2); COG: COG1186 Protein chain release factor B; Psort location: cytoplasmic, score: 23 YP_001573524.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001573525.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_001573526.1 KEGG: eci:UTI89_C3250 7.3e-65 ygeR; hypothetical lipoprotein YgeR precursor; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: nuclear, score: 23 YP_001573527.1 Psort location: endoplasmic reticulum, score: 9 YP_001573528.1 COG: COG5529 Pyocin large subunit; Psort location: cytoplasmic, score: 23 YP_001573529.1 Psort location: cytoskeletal, score: 9 YP_001573530.1 Psort location: extracellular, including cell wall, score: 9 YP_001573531.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001573532.1 COG: COG3547 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001573533.1 Psort location: extracellular, including cell wall, score: 9 YP_001573534.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001573535.1 COG: NOG19086 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001573536.1 COG: NOG26180 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573537.1 COG: NOG26180 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001573538.1 KEGG: sec:SC0997 6.0e-70 sodC; Gifsy-2 prophage superoxide dismutase precursor (Cu-Zn) K04565; COG: COG2032 Cu/Zn superoxide dismutase; Psort location: endoplasmic reticulum, score: 9 YP_001573539.1 KEGG: eci:UTI89_C1139 1.7e-25 putative autotransporter; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: cytoplasmic, score: 23 YP_001573540.1 Psort location: mitochondrial, score: 23 YP_001573541.1 KEGG: bur:Bcep18194_C7173 2.8e-07 two component transcriptional regulator, AraC family; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001573542.1 membrane protein conferring nickel and cobalt resistance YP_001573543.1 COG: COG1937 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573544.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001573545.1 Psort location: cytoplasmic, score: 23 YP_001573546.1 Psort location: nuclear, score: 23 YP_001573547.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001573548.1 Psort location: cytoplasmic, score: 23 YP_001573549.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001573550.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_001573551.1 Psort location: cytoplasmic, score: 23 YP_001573552.1 KEGG: cal:orf19.3526 4.6e-56 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001573553.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_001573554.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_001573555.1 KEGG: efa:EF1922 0.0022 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001573556.1 controls transcription of galETKM YP_001573557.1 Psort location: cytoplasmic, score: 23 YP_001573558.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_001573559.1 KEGG: pca:Pcar_2776 7.7e-23 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001573560.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_001573561.1 COG: NOG13901 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001573562.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001573563.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_001573564.1 hydrolyzes diadenosine polyphosphate YP_001573565.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_001573566.1 Psort location: cytoplasmic, score: 23 YP_001573567.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001573568.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001573570.1 COG: COG2165 Type II secretory pathway, pseudopilin PulG; Psort location: extracellular, including cell wall, score: 9 YP_001573571.1 COG: COG4795 Type II secretory pathway, component PulJ; Psort location: mitochondrial, score: 23 YP_001573572.1 COG: NOG10274 non supervised orthologous group; Psort location: golgi, score: 9 YP_001573573.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_001573574.1 KEGG: stm:STM2995 0. ptr; protease III K01407; COG: COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like; Psort location: extracellular, including cell wall, score: 9 YP_001573575.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001573576.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001573577.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001573578.1 KEGG: stm:STM2991 1.2e-213 amiC; N-acetylmuramoyl-L-alanine amidase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: mitochondrial, score: 23 YP_001573579.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001573580.1 KEGG: cal:orf19.2115 1.4e-25 molybdopterin-converting factor; COG: COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 1; Psort location: cytoplasmic, score: 23 YP_001573581.1 COG: COG2962 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001573582.1 Psort location: cytoplasmic, score: 23 YP_001573583.1 KEGG: cps:CPS_2211 1.2e-13 putative selenocysteine lyase K02426; COG: COG2166 SufE protein probably involved in Fe-S center assembly; Psort location: cytoplasmic, score: 23 YP_001573584.1 KEGG: stm:STM2984 1.8e-205 csdA; putative selenocysteine lyase; COG: COG0520 Selenocysteine lyase; Psort location: cytoplasmic, score: 23 YP_001573585.1 COG: NOG14132 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001573586.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_001573587.1 COG: COG2363 Uncharacterized small membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001573588.1 KEGG: vfi:VF0593 5.2e-119 methyltransferase; COG: COG2933 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001573589.1 regulates expression of genes involved in L-fucose utilization YP_001573590.1 COG: COG4154 Fucose dissimilation pathway protein FucU; Psort location: extracellular, including cell wall, score: 9 YP_001573591.1 KEGG: stm:STM2977 2.7e-248 fucK; L-fuculokinase K00879; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001573592.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_001573593.1 COG: COG0738 Fucose permease; Psort location: plasma membrane, score: 23 YP_001573594.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_001573595.1 KEGG: stm:STM2973 3.6e-198 fucO; L-1,2-propanediol oxidoreductase K00048; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001573596.1 KEGG: stm:STM2972 1.6e-92 xni, exo; exonuclease IX K01146; COG: COG0258 5-3 exonuclease (including N-terminal domain of PolI); Psort location: cytoplasmic, score: 23 YP_001573597.1 Psort location: cytoplasmic, score: 23 YP_001573598.1 KEGG: stm:STM2971 9.4e-239 sdaB; L-serine dehydratase (L-threonine deaminase 2) K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001573599.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001573600.1 KEGG: hch:HCH_00651 1.3e-129 predicted Rossmann fold nucleotide-binding protein K00052; COG: COG1611 Predicted Rossmann fold nucleotide-binding protein; Psort location: cytoplasmic, score: 23 YP_001573601.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001573602.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_001573603.1 KEGG: shn:Shewana3_2825 8.1e-11 dTDP-4-dehydrorhamnose 3,5-epimerase K01790; COG: COG3098 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001573604.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_001573605.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001573606.1 Psort location: nuclear, score: 23