-- dump date   	20140620_043214
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
866913000001	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
866913000002	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
866913000003	purine monophosphate binding site [chemical binding]; other site
866913000004	dimer interface [polypeptide binding]; other site
866913000005	putative catalytic residues [active]
866913000006	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
866913000007	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
866913000008	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
866913000009	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
866913000010	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
866913000011	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
866913000012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913000013	active site
866913000014	phosphorylation site [posttranslational modification]
866913000015	intermolecular recognition site; other site
866913000016	dimerization interface [polypeptide binding]; other site
866913000017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913000018	Walker A motif; other site
866913000019	ATP binding site [chemical binding]; other site
866913000020	Walker B motif; other site
866913000021	arginine finger; other site
866913000022	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866913000023	sensor protein ZraS; Provisional; Region: PRK10364
866913000024	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913000025	dimer interface [polypeptide binding]; other site
866913000026	phosphorylation site [posttranslational modification]
866913000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913000028	ATP binding site [chemical binding]; other site
866913000029	Mg2+ binding site [ion binding]; other site
866913000030	G-X-G motif; other site
866913000031	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
866913000032	dimer interface [polypeptide binding]; other site
866913000033	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
866913000034	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
866913000035	IHF dimer interface [polypeptide binding]; other site
866913000036	IHF - DNA interface [nucleotide binding]; other site
866913000037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
866913000038	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
866913000039	Active_site [active]
866913000040	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
866913000041	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
866913000042	substrate binding site [chemical binding]; other site
866913000043	active site
866913000044	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
866913000045	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
866913000046	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
866913000047	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
866913000048	putative NADH binding site [chemical binding]; other site
866913000049	putative active site [active]
866913000050	nudix motif; other site
866913000051	putative metal binding site [ion binding]; other site
866913000052	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
866913000053	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
866913000054	ThiC-associated domain; Region: ThiC-associated; pfam13667
866913000055	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
866913000056	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
866913000057	thiamine phosphate binding site [chemical binding]; other site
866913000058	active site
866913000059	pyrophosphate binding site [ion binding]; other site
866913000060	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
866913000061	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
866913000062	ATP binding site [chemical binding]; other site
866913000063	substrate interface [chemical binding]; other site
866913000064	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
866913000065	thiS-thiF/thiG interaction site; other site
866913000066	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
866913000067	ThiS interaction site; other site
866913000068	putative active site [active]
866913000069	tetramer interface [polypeptide binding]; other site
866913000070	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
866913000071	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913000072	FeS/SAM binding site; other site
866913000073	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
866913000074	type III secretion system protein; Provisional; Region: PRK15384
866913000075	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
866913000076	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
866913000077	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
866913000078	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
866913000079	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
866913000080	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
866913000081	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
866913000082	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
866913000083	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
866913000084	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
866913000085	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
866913000086	DNA binding site [nucleotide binding]
866913000087	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
866913000088	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
866913000089	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
866913000090	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
866913000091	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
866913000092	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
866913000093	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
866913000094	RPB3 interaction site [polypeptide binding]; other site
866913000095	RPB1 interaction site [polypeptide binding]; other site
866913000096	RPB11 interaction site [polypeptide binding]; other site
866913000097	RPB10 interaction site [polypeptide binding]; other site
866913000098	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
866913000099	core dimer interface [polypeptide binding]; other site
866913000100	peripheral dimer interface [polypeptide binding]; other site
866913000101	L10 interface [polypeptide binding]; other site
866913000102	L11 interface [polypeptide binding]; other site
866913000103	putative EF-Tu interaction site [polypeptide binding]; other site
866913000104	putative EF-G interaction site [polypeptide binding]; other site
866913000105	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
866913000106	23S rRNA interface [nucleotide binding]; other site
866913000107	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
866913000108	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
866913000109	mRNA/rRNA interface [nucleotide binding]; other site
866913000110	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
866913000111	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
866913000112	23S rRNA interface [nucleotide binding]; other site
866913000113	L7/L12 interface [polypeptide binding]; other site
866913000114	putative thiostrepton binding site; other site
866913000115	L25 interface [polypeptide binding]; other site
866913000116	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
866913000117	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
866913000118	putative homodimer interface [polypeptide binding]; other site
866913000119	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
866913000120	heterodimer interface [polypeptide binding]; other site
866913000121	homodimer interface [polypeptide binding]; other site
866913000122	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
866913000123	elongation factor Tu; Reviewed; Region: PRK00049
866913000124	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
866913000125	G1 box; other site
866913000126	GEF interaction site [polypeptide binding]; other site
866913000127	GTP/Mg2+ binding site [chemical binding]; other site
866913000128	Switch I region; other site
866913000129	G2 box; other site
866913000130	G3 box; other site
866913000131	Switch II region; other site
866913000132	G4 box; other site
866913000133	G5 box; other site
866913000134	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
866913000135	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
866913000136	Antibiotic Binding Site [chemical binding]; other site
866913000137	pantothenate kinase; Provisional; Region: PRK05439
866913000138	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
866913000139	ATP-binding site [chemical binding]; other site
866913000140	CoA-binding site [chemical binding]; other site
866913000141	Mg2+-binding site [ion binding]; other site
866913000142	Biotin operon repressor [Transcription]; Region: BirA; COG1654
866913000143	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
866913000144	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
866913000145	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
866913000146	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
866913000147	FAD binding domain; Region: FAD_binding_4; pfam01565
866913000148	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
866913000149	glutamate racemase; Provisional; Region: PRK00865
866913000150	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
866913000151	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913000152	N-terminal plug; other site
866913000153	ligand-binding site [chemical binding]; other site
866913000154	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
866913000155	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
866913000156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913000157	S-adenosylmethionine binding site [chemical binding]; other site
866913000158	hypothetical protein; Provisional; Region: PRK11056
866913000159	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
866913000160	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913000161	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
866913000162	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913000163	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866913000164	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
866913000165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913000166	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
866913000167	dimerization interface [polypeptide binding]; other site
866913000168	argininosuccinate lyase; Provisional; Region: PRK04833
866913000169	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
866913000170	active sites [active]
866913000171	tetramer interface [polypeptide binding]; other site
866913000172	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
866913000173	nucleotide binding site [chemical binding]; other site
866913000174	N-acetyl-L-glutamate binding site [chemical binding]; other site
866913000175	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
866913000176	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866913000177	acetylornithine deacetylase; Provisional; Region: PRK05111
866913000178	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
866913000179	metal binding site [ion binding]; metal-binding site
866913000180	putative dimer interface [polypeptide binding]; other site
866913000181	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
866913000182	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
866913000183	hypothetical protein; Provisional; Region: PRK10649
866913000184	Sulfatase; Region: Sulfatase; pfam00884
866913000185	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913000186	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913000187	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866913000188	active site
866913000189	P-loop; other site
866913000190	phosphorylation site [posttranslational modification]
866913000191	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913000192	FeS/SAM binding site; other site
866913000193	pyruvate formate lyase II activase; Provisional; Region: PRK10076
866913000194	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
866913000195	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
866913000196	dimer interface [polypeptide binding]; other site
866913000197	active site
866913000198	glycine loop; other site
866913000199	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866913000200	active site
866913000201	P-loop; other site
866913000202	phosphorylation site [posttranslational modification]
866913000203	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
866913000204	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
866913000205	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866913000206	dimerization domain swap beta strand [polypeptide binding]; other site
866913000207	regulatory protein interface [polypeptide binding]; other site
866913000208	active site
866913000209	regulatory phosphorylation site [posttranslational modification]; other site
866913000210	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
866913000211	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
866913000212	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866913000213	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866913000214	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913000215	active site
866913000216	phosphorylation site [posttranslational modification]
866913000217	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
866913000218	active site
866913000219	intersubunit interactions; other site
866913000220	catalytic residue [active]
866913000221	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
866913000222	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
866913000223	dimer interface [polypeptide binding]; other site
866913000224	active site
866913000225	metal binding site [ion binding]; metal-binding site
866913000226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
866913000227	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
866913000228	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
866913000229	heme binding site [chemical binding]; other site
866913000230	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
866913000231	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
866913000232	FAD binding site [chemical binding]; other site
866913000233	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
866913000234	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
866913000235	active site
866913000236	metal binding site [ion binding]; metal-binding site
866913000237	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866913000238	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
866913000239	mechanosensitive channel MscS; Provisional; Region: PRK10334
866913000240	Conserved TM helix; Region: TM_helix; pfam05552
866913000241	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913000242	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
866913000243	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
866913000244	putative catalytic residues [active]
866913000245	putative nucleotide binding site [chemical binding]; other site
866913000246	putative aspartate binding site [chemical binding]; other site
866913000247	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
866913000248	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
866913000249	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
866913000250	cystathionine gamma-synthase; Provisional; Region: PRK08045
866913000251	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866913000252	homodimer interface [polypeptide binding]; other site
866913000253	substrate-cofactor binding pocket; other site
866913000254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913000255	catalytic residue [active]
866913000256	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
866913000257	dimerization interface [polypeptide binding]; other site
866913000258	DNA binding site [nucleotide binding]
866913000259	corepressor binding sites; other site
866913000260	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
866913000261	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
866913000262	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
866913000263	primosome assembly protein PriA; Validated; Region: PRK05580
866913000264	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913000265	ATP binding site [chemical binding]; other site
866913000266	putative Mg++ binding site [ion binding]; other site
866913000267	helicase superfamily c-terminal domain; Region: HELICc; smart00490
866913000268	ATP-binding site [chemical binding]; other site
866913000269	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913000270	DNA binding site [nucleotide binding]
866913000271	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
866913000272	domain linker motif; other site
866913000273	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
866913000274	dimerization interface [polypeptide binding]; other site
866913000275	ligand binding site [chemical binding]; other site
866913000276	essential cell division protein FtsN; Provisional; Region: PRK10927
866913000277	cell division protein FtsN; Provisional; Region: PRK12757
866913000278	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
866913000279	active site
866913000280	HslU subunit interaction site [polypeptide binding]; other site
866913000281	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
866913000282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913000283	Walker A motif; other site
866913000284	ATP binding site [chemical binding]; other site
866913000285	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
866913000286	Walker B motif; other site
866913000287	arginine finger; other site
866913000288	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
866913000289	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
866913000290	UbiA prenyltransferase family; Region: UbiA; pfam01040
866913000291	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
866913000292	septal ring assembly protein ZapB; Provisional; Region: PRK15422
866913000293	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
866913000294	amphipathic channel; other site
866913000295	Asn-Pro-Ala signature motifs; other site
866913000296	glycerol kinase; Provisional; Region: glpK; PRK00047
866913000297	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
866913000298	N- and C-terminal domain interface [polypeptide binding]; other site
866913000299	active site
866913000300	MgATP binding site [chemical binding]; other site
866913000301	catalytic site [active]
866913000302	metal binding site [ion binding]; metal-binding site
866913000303	glycerol binding site [chemical binding]; other site
866913000304	homotetramer interface [polypeptide binding]; other site
866913000305	homodimer interface [polypeptide binding]; other site
866913000306	FBP binding site [chemical binding]; other site
866913000307	protein IIAGlc interface [polypeptide binding]; other site
866913000308	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
866913000309	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
866913000310	putative active site [active]
866913000311	ferredoxin-NADP reductase; Provisional; Region: PRK10926
866913000312	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
866913000313	FAD binding pocket [chemical binding]; other site
866913000314	FAD binding motif [chemical binding]; other site
866913000315	phosphate binding motif [ion binding]; other site
866913000316	beta-alpha-beta structure motif; other site
866913000317	NAD binding pocket [chemical binding]; other site
866913000318	Predicted membrane protein [Function unknown]; Region: COG3152
866913000319	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
866913000320	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
866913000321	triosephosphate isomerase; Provisional; Region: PRK14567
866913000322	substrate binding site [chemical binding]; other site
866913000323	dimer interface [polypeptide binding]; other site
866913000324	catalytic triad [active]
866913000325	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
866913000326	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866913000327	substrate binding site [chemical binding]; other site
866913000328	hexamer interface [polypeptide binding]; other site
866913000329	metal binding site [ion binding]; metal-binding site
866913000330	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
866913000331	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
866913000332	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
866913000333	putative active site; other site
866913000334	catalytic residue [active]
866913000335	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
866913000336	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
866913000337	ligand binding site [chemical binding]; other site
866913000338	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866913000339	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866913000340	TM-ABC transporter signature motif; other site
866913000341	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866913000342	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866913000343	TM-ABC transporter signature motif; other site
866913000344	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
866913000345	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
866913000346	Walker A/P-loop; other site
866913000347	ATP binding site [chemical binding]; other site
866913000348	Q-loop/lid; other site
866913000349	ABC transporter signature motif; other site
866913000350	Walker B; other site
866913000351	D-loop; other site
866913000352	H-loop/switch region; other site
866913000353	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866913000354	transcriptional regulator LsrR; Provisional; Region: PRK15418
866913000355	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
866913000356	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
866913000357	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
866913000358	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
866913000359	putative N- and C-terminal domain interface [polypeptide binding]; other site
866913000360	putative active site [active]
866913000361	putative MgATP binding site [chemical binding]; other site
866913000362	catalytic site [active]
866913000363	metal binding site [ion binding]; metal-binding site
866913000364	putative carbohydrate binding site [chemical binding]; other site
866913000365	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866913000366	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
866913000367	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
866913000368	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866913000369	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913000370	DNA-binding site [nucleotide binding]; DNA binding site
866913000371	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
866913000372	UTRA domain; Region: UTRA; pfam07702
866913000373	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
866913000374	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913000375	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
866913000376	putative substrate binding site [chemical binding]; other site
866913000377	putative ATP binding site [chemical binding]; other site
866913000378	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
866913000379	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
866913000380	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
866913000381	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
866913000382	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913000383	substrate binding pocket [chemical binding]; other site
866913000384	membrane-bound complex binding site; other site
866913000385	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
866913000386	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
866913000387	active site
866913000388	ADP/pyrophosphate binding site [chemical binding]; other site
866913000389	dimerization interface [polypeptide binding]; other site
866913000390	allosteric effector site; other site
866913000391	fructose-1,6-bisphosphate binding site; other site
866913000392	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
866913000393	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
866913000394	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
866913000395	dimer interface [polypeptide binding]; other site
866913000396	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
866913000397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913000398	active site
866913000399	intermolecular recognition site; other site
866913000400	dimerization interface [polypeptide binding]; other site
866913000401	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913000402	DNA binding site [nucleotide binding]
866913000403	two-component sensor protein; Provisional; Region: cpxA; PRK09470
866913000404	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913000405	dimerization interface [polypeptide binding]; other site
866913000406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913000407	dimer interface [polypeptide binding]; other site
866913000408	phosphorylation site [posttranslational modification]
866913000409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913000410	ATP binding site [chemical binding]; other site
866913000411	Mg2+ binding site [ion binding]; other site
866913000412	G-X-G motif; other site
866913000413	SnoaL-like domain; Region: SnoaL_2; pfam12680
866913000414	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
866913000415	MOSC domain; Region: MOSC; pfam03473
866913000416	3-alpha domain; Region: 3-alpha; pfam03475
866913000417	superoxide dismutase; Provisional; Region: PRK10925
866913000418	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
866913000419	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
866913000420	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
866913000421	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
866913000422	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
866913000423	DctM-like transporters; Region: DctM; pfam06808
866913000424	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
866913000425	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
866913000426	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
866913000427	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
866913000428	transcriptional activator RhaR; Provisional; Region: PRK13502
866913000429	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
866913000430	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913000431	transcriptional activator RhaS; Provisional; Region: PRK13503
866913000432	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
866913000433	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913000434	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913000435	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
866913000436	N- and C-terminal domain interface [polypeptide binding]; other site
866913000437	active site
866913000438	putative catalytic site [active]
866913000439	metal binding site [ion binding]; metal-binding site
866913000440	ATP binding site [chemical binding]; other site
866913000441	rhamnulokinase; Provisional; Region: rhaB; PRK10640
866913000442	carbohydrate binding site [chemical binding]; other site
866913000443	L-rhamnose isomerase; Provisional; Region: PRK01076
866913000444	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
866913000445	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
866913000446	intersubunit interface [polypeptide binding]; other site
866913000447	active site
866913000448	Zn2+ binding site [ion binding]; other site
866913000449	lactaldehyde reductase; Region: lactal_redase; TIGR02638
866913000450	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
866913000451	dimer interface [polypeptide binding]; other site
866913000452	active site
866913000453	metal binding site [ion binding]; metal-binding site
866913000454	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
866913000455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913000456	non-specific DNA binding site [nucleotide binding]; other site
866913000457	salt bridge; other site
866913000458	sequence-specific DNA binding site [nucleotide binding]; other site
866913000459	Cupin domain; Region: Cupin_2; cl17218
866913000460	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
866913000461	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
866913000462	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
866913000463	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
866913000464	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
866913000465	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913000466	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913000467	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
866913000468	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
866913000469	molybdopterin cofactor binding site; other site
866913000470	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
866913000471	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
866913000472	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
866913000473	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
866913000474	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
866913000475	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
866913000476	Predicted transcriptional regulator [Transcription]; Region: COG2944
866913000477	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913000478	non-specific DNA binding site [nucleotide binding]; other site
866913000479	salt bridge; other site
866913000480	sequence-specific DNA binding site [nucleotide binding]; other site
866913000481	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
866913000482	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
866913000483	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
866913000484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
866913000485	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913000486	non-specific DNA binding site [nucleotide binding]; other site
866913000487	salt bridge; other site
866913000488	sequence-specific DNA binding site [nucleotide binding]; other site
866913000489	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913000490	Coenzyme A binding pocket [chemical binding]; other site
866913000491	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
866913000492	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
866913000493	putative active site [active]
866913000494	dimerization interface [polypeptide binding]; other site
866913000495	putative tRNAtyr binding site [nucleotide binding]; other site
866913000496	hypothetical protein; Reviewed; Region: PRK01637
866913000497	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
866913000498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913000499	motif II; other site
866913000500	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913000501	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913000502	putative DNA binding site [nucleotide binding]; other site
866913000503	putative Zn2+ binding site [ion binding]; other site
866913000504	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913000505	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913000506	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
866913000507	substrate binding site [chemical binding]; other site
866913000508	ATP binding site [chemical binding]; other site
866913000509	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
866913000510	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866913000511	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
866913000512	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
866913000513	dimerization interface [polypeptide binding]; other site
866913000514	putative active cleft [active]
866913000515	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
866913000516	active site
866913000517	catalytic residues [active]
866913000518	alpha-glucosidase; Provisional; Region: PRK10426
866913000519	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
866913000520	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
866913000521	putative active site [active]
866913000522	putative catalytic site [active]
866913000523	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
866913000524	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
866913000525	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
866913000526	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913000527	putative substrate translocation pore; other site
866913000528	outer membrane porin L; Provisional; Region: ompL; PRK09980
866913000529	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
866913000530	Sulfatase; Region: Sulfatase; cl17466
866913000531	coproporphyrinogen III oxidase; Validated; Region: PRK08208
866913000532	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913000533	FeS/SAM binding site; other site
866913000534	HemN C-terminal domain; Region: HemN_C; pfam06969
866913000535	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913000536	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866913000537	active site
866913000538	motif I; other site
866913000539	motif II; other site
866913000540	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913000541	GTP-binding protein; Provisional; Region: PRK10218
866913000542	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
866913000543	G1 box; other site
866913000544	putative GEF interaction site [polypeptide binding]; other site
866913000545	GTP/Mg2+ binding site [chemical binding]; other site
866913000546	Switch I region; other site
866913000547	G2 box; other site
866913000548	G3 box; other site
866913000549	Switch II region; other site
866913000550	G4 box; other site
866913000551	G5 box; other site
866913000552	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
866913000553	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
866913000554	glutamine synthetase; Provisional; Region: glnA; PRK09469
866913000555	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
866913000556	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
866913000557	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
866913000558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913000559	putative active site [active]
866913000560	heme pocket [chemical binding]; other site
866913000561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913000562	dimer interface [polypeptide binding]; other site
866913000563	phosphorylation site [posttranslational modification]
866913000564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913000565	ATP binding site [chemical binding]; other site
866913000566	Mg2+ binding site [ion binding]; other site
866913000567	G-X-G motif; other site
866913000568	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
866913000569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913000570	active site
866913000571	phosphorylation site [posttranslational modification]
866913000572	intermolecular recognition site; other site
866913000573	dimerization interface [polypeptide binding]; other site
866913000574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913000575	Walker A motif; other site
866913000576	ATP binding site [chemical binding]; other site
866913000577	Walker B motif; other site
866913000578	arginine finger; other site
866913000579	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866913000580	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
866913000581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913000582	FeS/SAM binding site; other site
866913000583	HemN C-terminal domain; Region: HemN_C; pfam06969
866913000584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
866913000585	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
866913000586	G1 box; other site
866913000587	GTP/Mg2+ binding site [chemical binding]; other site
866913000588	Switch I region; other site
866913000589	G2 box; other site
866913000590	G3 box; other site
866913000591	Switch II region; other site
866913000592	G4 box; other site
866913000593	G5 box; other site
866913000594	DNA polymerase I; Provisional; Region: PRK05755
866913000595	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
866913000596	active site
866913000597	metal binding site 1 [ion binding]; metal-binding site
866913000598	putative 5' ssDNA interaction site; other site
866913000599	metal binding site 3; metal-binding site
866913000600	metal binding site 2 [ion binding]; metal-binding site
866913000601	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
866913000602	putative DNA binding site [nucleotide binding]; other site
866913000603	putative metal binding site [ion binding]; other site
866913000604	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
866913000605	active site
866913000606	catalytic site [active]
866913000607	substrate binding site [chemical binding]; other site
866913000608	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
866913000609	active site
866913000610	DNA binding site [nucleotide binding]
866913000611	catalytic site [active]
866913000612	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
866913000613	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
866913000614	putative acyl-acceptor binding pocket; other site
866913000615	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
866913000616	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
866913000617	catalytic residues [active]
866913000618	hinge region; other site
866913000619	alpha helical domain; other site
866913000620	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
866913000621	serine/threonine protein kinase; Provisional; Region: PRK11768
866913000622	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
866913000623	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
866913000624	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
866913000625	GTP binding site; other site
866913000626	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
866913000627	Walker A motif; other site
866913000628	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
866913000629	potassium transporter; Provisional; Region: PRK10750
866913000630	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
866913000631	hypothetical protein; Provisional; Region: PRK11568
866913000632	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
866913000633	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
866913000634	proline dipeptidase; Provisional; Region: PRK13607
866913000635	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
866913000636	active site
866913000637	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
866913000638	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866913000639	substrate binding site [chemical binding]; other site
866913000640	oxyanion hole (OAH) forming residues; other site
866913000641	trimer interface [polypeptide binding]; other site
866913000642	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866913000643	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866913000644	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866913000645	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
866913000646	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866913000647	dimer interface [polypeptide binding]; other site
866913000648	active site
866913000649	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
866913000650	FMN reductase; Validated; Region: fre; PRK08051
866913000651	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
866913000652	FAD binding pocket [chemical binding]; other site
866913000653	FAD binding motif [chemical binding]; other site
866913000654	phosphate binding motif [ion binding]; other site
866913000655	beta-alpha-beta structure motif; other site
866913000656	NAD binding pocket [chemical binding]; other site
866913000657	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
866913000658	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
866913000659	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
866913000660	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
866913000661	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
866913000662	active site
866913000663	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
866913000664	sec-independent translocase; Provisional; Region: PRK01770
866913000665	sec-independent translocase; Provisional; Region: tatB; PRK00404
866913000666	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
866913000667	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
866913000668	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
866913000669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
866913000670	SCP-2 sterol transfer family; Region: SCP2; pfam02036
866913000671	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
866913000672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913000673	S-adenosylmethionine binding site [chemical binding]; other site
866913000674	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
866913000675	DNA recombination protein RmuC; Provisional; Region: PRK10361
866913000676	RmuC family; Region: RmuC; pfam02646
866913000677	uridine phosphorylase; Provisional; Region: PRK11178
866913000678	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
866913000679	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
866913000680	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
866913000681	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913000682	FeS/SAM binding site; other site
866913000683	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
866913000684	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
866913000685	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
866913000686	THF binding site; other site
866913000687	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
866913000688	substrate binding site [chemical binding]; other site
866913000689	THF binding site; other site
866913000690	zinc-binding site [ion binding]; other site
866913000691	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
866913000692	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913000693	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
866913000694	putative dimerization interface [polypeptide binding]; other site
866913000695	putative hydrolase; Provisional; Region: PRK10976
866913000696	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913000697	active site
866913000698	motif I; other site
866913000699	motif II; other site
866913000700	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913000701	lysophospholipase L2; Provisional; Region: PRK10749
866913000702	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866913000703	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
866913000704	threonine efflux system; Provisional; Region: PRK10229
866913000705	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
866913000706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913000707	ATP binding site [chemical binding]; other site
866913000708	putative Mg++ binding site [ion binding]; other site
866913000709	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913000710	nucleotide binding region [chemical binding]; other site
866913000711	ATP-binding site [chemical binding]; other site
866913000712	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
866913000713	Helicase and RNase D C-terminal; Region: HRDC; smart00341
866913000714	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
866913000715	dimerization interface [polypeptide binding]; other site
866913000716	substrate binding site [chemical binding]; other site
866913000717	active site
866913000718	calcium binding site [ion binding]; other site
866913000719	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
866913000720	CoenzymeA binding site [chemical binding]; other site
866913000721	subunit interaction site [polypeptide binding]; other site
866913000722	PHB binding site; other site
866913000723	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
866913000724	EamA-like transporter family; Region: EamA; cl17759
866913000725	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
866913000726	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
866913000727	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
866913000728	Cl binding site [ion binding]; other site
866913000729	oligomer interface [polypeptide binding]; other site
866913000730	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
866913000731	Part of AAA domain; Region: AAA_19; pfam13245
866913000732	Family description; Region: UvrD_C_2; pfam13538
866913000733	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
866913000734	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913000735	motif II; other site
866913000736	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
866913000737	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
866913000738	active site
866913000739	Int/Topo IB signature motif; other site
866913000740	hypothetical protein; Provisional; Region: PRK10963
866913000741	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
866913000742	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
866913000743	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
866913000744	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
866913000745	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
866913000746	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
866913000747	putative iron binding site [ion binding]; other site
866913000748	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
866913000749	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
866913000750	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
866913000751	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
866913000752	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
866913000753	domain interfaces; other site
866913000754	active site
866913000755	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
866913000756	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
866913000757	active site
866913000758	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
866913000759	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
866913000760	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
866913000761	HemY protein N-terminus; Region: HemY_N; pfam07219
866913000762	putative transport protein YifK; Provisional; Region: PRK10746
866913000763	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
866913000764	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
866913000765	putative common antigen polymerase; Provisional; Region: PRK02975
866913000766	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
866913000767	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866913000768	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
866913000769	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
866913000770	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
866913000771	inhibitor-cofactor binding pocket; inhibition site
866913000772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913000773	catalytic residue [active]
866913000774	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
866913000775	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
866913000776	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913000777	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
866913000778	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
866913000779	NAD binding site [chemical binding]; other site
866913000780	substrate binding site [chemical binding]; other site
866913000781	homodimer interface [polypeptide binding]; other site
866913000782	active site
866913000783	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
866913000784	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
866913000785	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
866913000786	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
866913000787	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
866913000788	active site
866913000789	homodimer interface [polypeptide binding]; other site
866913000790	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
866913000791	Chain length determinant protein; Region: Wzz; pfam02706
866913000792	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
866913000793	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
866913000794	Mg++ binding site [ion binding]; other site
866913000795	putative catalytic motif [active]
866913000796	substrate binding site [chemical binding]; other site
866913000797	transcription termination factor Rho; Provisional; Region: rho; PRK09376
866913000798	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
866913000799	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
866913000800	RNA binding site [nucleotide binding]; other site
866913000801	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
866913000802	multimer interface [polypeptide binding]; other site
866913000803	Walker A motif; other site
866913000804	ATP binding site [chemical binding]; other site
866913000805	Walker B motif; other site
866913000806	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866913000807	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866913000808	catalytic residues [active]
866913000809	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
866913000810	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866913000811	ATP binding site [chemical binding]; other site
866913000812	Mg++ binding site [ion binding]; other site
866913000813	motif III; other site
866913000814	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913000815	nucleotide binding region [chemical binding]; other site
866913000816	ATP-binding site [chemical binding]; other site
866913000817	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
866913000818	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
866913000819	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
866913000820	Part of AAA domain; Region: AAA_19; pfam13245
866913000821	Family description; Region: UvrD_C_2; pfam13538
866913000822	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
866913000823	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
866913000824	ketol-acid reductoisomerase; Validated; Region: PRK05225
866913000825	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
866913000826	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
866913000827	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
866913000828	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913000829	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
866913000830	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
866913000831	putative dimerization interface [polypeptide binding]; other site
866913000832	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
866913000833	Phage-related protein [Function unknown]; Region: COG4679
866913000834	threonine dehydratase; Reviewed; Region: PRK09224
866913000835	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
866913000836	tetramer interface [polypeptide binding]; other site
866913000837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913000838	catalytic residue [active]
866913000839	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
866913000840	putative Ile/Val binding site [chemical binding]; other site
866913000841	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
866913000842	putative Ile/Val binding site [chemical binding]; other site
866913000843	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
866913000844	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
866913000845	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
866913000846	homodimer interface [polypeptide binding]; other site
866913000847	substrate-cofactor binding pocket; other site
866913000848	catalytic residue [active]
866913000849	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
866913000850	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
866913000851	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866913000852	PYR/PP interface [polypeptide binding]; other site
866913000853	dimer interface [polypeptide binding]; other site
866913000854	TPP binding site [chemical binding]; other site
866913000855	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866913000856	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
866913000857	TPP-binding site [chemical binding]; other site
866913000858	dimer interface [polypeptide binding]; other site
866913000859	putative ATP-dependent protease; Provisional; Region: PRK09862
866913000860	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
866913000861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913000862	Walker A motif; other site
866913000863	ATP binding site [chemical binding]; other site
866913000864	Walker B motif; other site
866913000865	arginine finger; other site
866913000866	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
866913000867	hypothetical protein; Provisional; Region: PRK11027
866913000868	transcriptional regulator HdfR; Provisional; Region: PRK03601
866913000869	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913000870	LysR substrate binding domain; Region: LysR_substrate; pfam03466
866913000871	dimerization interface [polypeptide binding]; other site
866913000872	Transcriptional regulators [Transcription]; Region: FadR; COG2186
866913000873	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913000874	DNA-binding site [nucleotide binding]; DNA binding site
866913000875	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
866913000876	putative transporter; Provisional; Region: PRK10504
866913000877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913000878	putative substrate translocation pore; other site
866913000879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913000880	transcriptional repressor RbsR; Provisional; Region: PRK10423
866913000881	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913000882	DNA binding site [nucleotide binding]
866913000883	domain linker motif; other site
866913000884	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
866913000885	dimerization interface [polypeptide binding]; other site
866913000886	ligand binding site [chemical binding]; other site
866913000887	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913000888	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866913000889	substrate binding site [chemical binding]; other site
866913000890	dimer interface [polypeptide binding]; other site
866913000891	ATP binding site [chemical binding]; other site
866913000892	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
866913000893	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
866913000894	ligand binding site [chemical binding]; other site
866913000895	dimerization interface [polypeptide binding]; other site
866913000896	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866913000897	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866913000898	TM-ABC transporter signature motif; other site
866913000899	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
866913000900	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
866913000901	Walker A/P-loop; other site
866913000902	ATP binding site [chemical binding]; other site
866913000903	Q-loop/lid; other site
866913000904	ABC transporter signature motif; other site
866913000905	Walker B; other site
866913000906	D-loop; other site
866913000907	H-loop/switch region; other site
866913000908	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866913000909	D-ribose pyranase; Provisional; Region: PRK11797
866913000910	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
866913000911	potassium uptake protein; Region: kup; TIGR00794
866913000912	regulatory ATPase RavA; Provisional; Region: PRK13531
866913000913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913000914	Walker A motif; other site
866913000915	ATP binding site [chemical binding]; other site
866913000916	Walker B motif; other site
866913000917	arginine finger; other site
866913000918	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
866913000919	hypothetical protein; Provisional; Region: yieM; PRK10997
866913000920	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
866913000921	metal ion-dependent adhesion site (MIDAS); other site
866913000922	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
866913000923	dimer interface [polypeptide binding]; other site
866913000924	active site
866913000925	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
866913000926	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913000927	putative DNA binding site [nucleotide binding]; other site
866913000928	putative Zn2+ binding site [ion binding]; other site
866913000929	AsnC family; Region: AsnC_trans_reg; pfam01037
866913000930	FMN-binding protein MioC; Provisional; Region: PRK09004
866913000931	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
866913000932	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
866913000933	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
866913000934	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
866913000935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913000936	S-adenosylmethionine binding site [chemical binding]; other site
866913000937	ATP synthase I chain; Region: ATP_synt_I; cl09170
866913000938	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
866913000939	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
866913000940	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
866913000941	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
866913000942	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
866913000943	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
866913000944	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
866913000945	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
866913000946	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866913000947	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
866913000948	beta subunit interaction interface [polypeptide binding]; other site
866913000949	Walker A motif; other site
866913000950	ATP binding site [chemical binding]; other site
866913000951	Walker B motif; other site
866913000952	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866913000953	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
866913000954	core domain interface [polypeptide binding]; other site
866913000955	delta subunit interface [polypeptide binding]; other site
866913000956	epsilon subunit interface [polypeptide binding]; other site
866913000957	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
866913000958	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866913000959	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
866913000960	alpha subunit interaction interface [polypeptide binding]; other site
866913000961	Walker A motif; other site
866913000962	ATP binding site [chemical binding]; other site
866913000963	Walker B motif; other site
866913000964	inhibitor binding site; inhibition site
866913000965	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866913000966	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
866913000967	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
866913000968	gamma subunit interface [polypeptide binding]; other site
866913000969	epsilon subunit interface [polypeptide binding]; other site
866913000970	LBP interface [polypeptide binding]; other site
866913000971	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
866913000972	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
866913000973	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
866913000974	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
866913000975	Substrate binding site; other site
866913000976	Mg++ binding site; other site
866913000977	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
866913000978	active site
866913000979	substrate binding site [chemical binding]; other site
866913000980	CoA binding site [chemical binding]; other site
866913000981	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
866913000982	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
866913000983	glutaminase active site [active]
866913000984	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
866913000985	dimer interface [polypeptide binding]; other site
866913000986	active site
866913000987	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866913000988	dimer interface [polypeptide binding]; other site
866913000989	active site
866913000990	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
866913000991	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
866913000992	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
866913000993	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
866913000994	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
866913000995	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
866913000996	shikimate binding site; other site
866913000997	NAD(P) binding site [chemical binding]; other site
866913000998	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866913000999	active site
866913001000	P-loop; other site
866913001001	phosphorylation site [posttranslational modification]
866913001002	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
866913001003	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
866913001004	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913001005	substrate binding pocket [chemical binding]; other site
866913001006	membrane-bound complex binding site; other site
866913001007	hinge residues; other site
866913001008	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
866913001009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913001010	dimer interface [polypeptide binding]; other site
866913001011	conserved gate region; other site
866913001012	putative PBP binding loops; other site
866913001013	ABC-ATPase subunit interface; other site
866913001014	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
866913001015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913001016	dimer interface [polypeptide binding]; other site
866913001017	conserved gate region; other site
866913001018	putative PBP binding loops; other site
866913001019	ABC-ATPase subunit interface; other site
866913001020	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
866913001021	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
866913001022	Walker A/P-loop; other site
866913001023	ATP binding site [chemical binding]; other site
866913001024	Q-loop/lid; other site
866913001025	ABC transporter signature motif; other site
866913001026	Walker B; other site
866913001027	D-loop; other site
866913001028	H-loop/switch region; other site
866913001029	transcriptional regulator PhoU; Provisional; Region: PRK11115
866913001030	PhoU domain; Region: PhoU; pfam01895
866913001031	PhoU domain; Region: PhoU; pfam01895
866913001032	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
866913001033	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913001034	active site
866913001035	motif I; other site
866913001036	motif II; other site
866913001037	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
866913001038	Predicted flavoprotein [General function prediction only]; Region: COG0431
866913001039	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866913001040	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
866913001041	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
866913001042	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913001043	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
866913001044	substrate binding pocket [chemical binding]; other site
866913001045	dimerization interface [polypeptide binding]; other site
866913001046	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
866913001047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001048	putative substrate translocation pore; other site
866913001049	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
866913001050	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
866913001051	putative active site [active]
866913001052	putative NTP binding site [chemical binding]; other site
866913001053	putative nucleic acid binding site [nucleotide binding]; other site
866913001054	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
866913001055	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
866913001056	active site
866913001057	Int/Topo IB signature motif; other site
866913001058	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866913001059	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
866913001060	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
866913001061	trmE is a tRNA modification GTPase; Region: trmE; cd04164
866913001062	G1 box; other site
866913001063	GTP/Mg2+ binding site [chemical binding]; other site
866913001064	Switch I region; other site
866913001065	G2 box; other site
866913001066	Switch II region; other site
866913001067	G3 box; other site
866913001068	G4 box; other site
866913001069	G5 box; other site
866913001070	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
866913001071	membrane protein insertase; Provisional; Region: PRK01318
866913001072	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
866913001073	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
866913001074	ribonuclease P; Reviewed; Region: rnpA; PRK01732
866913001075	DnaA N-terminal domain; Region: DnaA_N; pfam11638
866913001076	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
866913001077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913001078	Walker A motif; other site
866913001079	ATP binding site [chemical binding]; other site
866913001080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866913001081	Walker B motif; other site
866913001082	arginine finger; other site
866913001083	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
866913001084	DnaA box-binding interface [nucleotide binding]; other site
866913001085	DNA polymerase III subunit beta; Validated; Region: PRK05643
866913001086	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
866913001087	putative DNA binding surface [nucleotide binding]; other site
866913001088	dimer interface [polypeptide binding]; other site
866913001089	beta-clamp/clamp loader binding surface; other site
866913001090	beta-clamp/translesion DNA polymerase binding surface; other site
866913001091	recF protein; Region: recf; TIGR00611
866913001092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913001093	Walker A/P-loop; other site
866913001094	ATP binding site [chemical binding]; other site
866913001095	Q-loop/lid; other site
866913001096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913001097	ABC transporter signature motif; other site
866913001098	Walker B; other site
866913001099	D-loop; other site
866913001100	H-loop/switch region; other site
866913001101	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
866913001102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913001103	Mg2+ binding site [ion binding]; other site
866913001104	G-X-G motif; other site
866913001105	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866913001106	anchoring element; other site
866913001107	dimer interface [polypeptide binding]; other site
866913001108	ATP binding site [chemical binding]; other site
866913001109	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
866913001110	active site
866913001111	putative metal-binding site [ion binding]; other site
866913001112	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866913001113	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913001114	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913001115	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
866913001116	putative dimerization interface [polypeptide binding]; other site
866913001117	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
866913001118	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
866913001119	active site pocket [active]
866913001120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001121	D-galactonate transporter; Region: 2A0114; TIGR00893
866913001122	putative substrate translocation pore; other site
866913001123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001124	sugar phosphate phosphatase; Provisional; Region: PRK10513
866913001125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913001126	active site
866913001127	motif I; other site
866913001128	motif II; other site
866913001129	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913001130	Transcriptional regulators [Transcription]; Region: FadR; COG2186
866913001131	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913001132	DNA-binding site [nucleotide binding]; DNA binding site
866913001133	FCD domain; Region: FCD; pfam07729
866913001134	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
866913001135	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
866913001136	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
866913001137	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
866913001138	active site
866913001139	intersubunit interface [polypeptide binding]; other site
866913001140	catalytic residue [active]
866913001141	galactonate dehydratase; Provisional; Region: PRK14017
866913001142	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
866913001143	putative active site pocket [active]
866913001144	putative metal binding site [ion binding]; other site
866913001145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001146	D-galactonate transporter; Region: 2A0114; TIGR00893
866913001147	putative substrate translocation pore; other site
866913001148	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
866913001149	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913001150	dimer interface [polypeptide binding]; other site
866913001151	phosphorylation site [posttranslational modification]
866913001152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913001153	ATP binding site [chemical binding]; other site
866913001154	Mg2+ binding site [ion binding]; other site
866913001155	G-X-G motif; other site
866913001156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913001157	active site
866913001158	phosphorylation site [posttranslational modification]
866913001159	intermolecular recognition site; other site
866913001160	dimerization interface [polypeptide binding]; other site
866913001161	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
866913001162	putative binding surface; other site
866913001163	active site
866913001164	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
866913001165	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866913001166	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
866913001167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913001168	active site
866913001169	phosphorylation site [posttranslational modification]
866913001170	intermolecular recognition site; other site
866913001171	dimerization interface [polypeptide binding]; other site
866913001172	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913001173	DNA binding site [nucleotide binding]
866913001174	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
866913001175	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
866913001176	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
866913001177	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
866913001178	molybdopterin cofactor binding site [chemical binding]; other site
866913001179	substrate binding site [chemical binding]; other site
866913001180	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
866913001181	molybdopterin cofactor binding site; other site
866913001182	chaperone protein TorD; Validated; Region: torD; PRK04976
866913001183	Haem-binding domain; Region: Haem_bd; pfam14376
866913001184	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
866913001185	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
866913001186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913001187	Walker A/P-loop; other site
866913001188	ATP binding site [chemical binding]; other site
866913001189	Q-loop/lid; other site
866913001190	ABC transporter signature motif; other site
866913001191	Walker B; other site
866913001192	D-loop; other site
866913001193	H-loop/switch region; other site
866913001194	heme exporter protein CcmB; Region: ccmB; TIGR01190
866913001195	heme exporter protein CcmC; Region: ccmC; TIGR01191
866913001196	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
866913001197	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
866913001198	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
866913001199	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
866913001200	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
866913001201	catalytic residues [active]
866913001202	central insert; other site
866913001203	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
866913001204	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
866913001205	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
866913001206	hypothetical protein; Provisional; Region: PRK11616
866913001207	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
866913001208	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
866913001209	putative dimer interface [polypeptide binding]; other site
866913001210	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
866913001211	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
866913001212	putative dimer interface [polypeptide binding]; other site
866913001213	putative transporter; Validated; Region: PRK03818
866913001214	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
866913001215	TrkA-C domain; Region: TrkA_C; pfam02080
866913001216	TrkA-C domain; Region: TrkA_C; pfam02080
866913001217	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
866913001218	Predicted membrane protein [Function unknown]; Region: COG2149
866913001219	Domain of unknown function (DUF202); Region: DUF202; pfam02656
866913001220	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
866913001221	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
866913001222	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
866913001223	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
866913001224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913001225	catalytic residue [active]
866913001226	permease DsdX; Provisional; Region: PRK09921
866913001227	gluconate transporter; Region: gntP; TIGR00791
866913001228	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
866913001229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913001230	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
866913001231	dimerization interface [polypeptide binding]; other site
866913001232	substrate binding pocket [chemical binding]; other site
866913001233	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
866913001234	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
866913001235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001236	putative substrate translocation pore; other site
866913001237	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
866913001238	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
866913001239	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
866913001240	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866913001241	PYR/PP interface [polypeptide binding]; other site
866913001242	dimer interface [polypeptide binding]; other site
866913001243	TPP binding site [chemical binding]; other site
866913001244	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866913001245	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
866913001246	TPP-binding site [chemical binding]; other site
866913001247	dimer interface [polypeptide binding]; other site
866913001248	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
866913001249	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
866913001250	putative valine binding site [chemical binding]; other site
866913001251	dimer interface [polypeptide binding]; other site
866913001252	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
866913001253	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
866913001254	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913001255	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913001256	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866913001257	substrate binding site [chemical binding]; other site
866913001258	dimer interface [polypeptide binding]; other site
866913001259	ATP binding site [chemical binding]; other site
866913001260	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
866913001261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001262	putative substrate translocation pore; other site
866913001263	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
866913001264	active site
866913001265	catalytic residues [active]
866913001266	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
866913001267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913001268	active site
866913001269	phosphorylation site [posttranslational modification]
866913001270	intermolecular recognition site; other site
866913001271	dimerization interface [polypeptide binding]; other site
866913001272	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913001273	DNA binding residues [nucleotide binding]
866913001274	dimerization interface [polypeptide binding]; other site
866913001275	sensory histidine kinase UhpB; Provisional; Region: PRK11644
866913001276	MASE1; Region: MASE1; pfam05231
866913001277	Histidine kinase; Region: HisKA_3; pfam07730
866913001278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913001279	ATP binding site [chemical binding]; other site
866913001280	Mg2+ binding site [ion binding]; other site
866913001281	G-X-G motif; other site
866913001282	regulatory protein UhpC; Provisional; Region: PRK11663
866913001283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001284	putative substrate translocation pore; other site
866913001285	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
866913001286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001287	putative substrate translocation pore; other site
866913001288	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
866913001289	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866913001290	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913001291	DNA-binding site [nucleotide binding]; DNA binding site
866913001292	UTRA domain; Region: UTRA; pfam07702
866913001293	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913001294	active site
866913001295	phosphorylation site [posttranslational modification]
866913001296	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
866913001297	active site
866913001298	P-loop; other site
866913001299	phosphorylation site [posttranslational modification]
866913001300	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
866913001301	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
866913001302	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
866913001303	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
866913001304	putative N- and C-terminal domain interface [polypeptide binding]; other site
866913001305	putative active site [active]
866913001306	putative MgATP binding site [chemical binding]; other site
866913001307	catalytic site [active]
866913001308	metal binding site [ion binding]; metal-binding site
866913001309	putative carbohydrate binding site [chemical binding]; other site
866913001310	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
866913001311	intersubunit interface [polypeptide binding]; other site
866913001312	active site
866913001313	zinc binding site [ion binding]; other site
866913001314	Na+ binding site [ion binding]; other site
866913001315	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866913001316	dimerization domain swap beta strand [polypeptide binding]; other site
866913001317	regulatory protein interface [polypeptide binding]; other site
866913001318	active site
866913001319	regulatory phosphorylation site [posttranslational modification]; other site
866913001320	Predicted transcriptional regulator [Transcription]; Region: COG2944
866913001321	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913001322	non-specific DNA binding site [nucleotide binding]; other site
866913001323	salt bridge; other site
866913001324	sequence-specific DNA binding site [nucleotide binding]; other site
866913001325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
866913001326	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
866913001327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001328	putative substrate translocation pore; other site
866913001329	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
866913001330	beta-galactosidase; Region: BGL; TIGR03356
866913001331	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
866913001332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913001333	Walker A motif; other site
866913001334	ATP binding site [chemical binding]; other site
866913001335	Walker B motif; other site
866913001336	arginine finger; other site
866913001337	Transcriptional antiterminator [Transcription]; Region: COG3933
866913001338	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
866913001339	active site
866913001340	active pocket/dimerization site; other site
866913001341	phosphorylation site [posttranslational modification]
866913001342	PRD domain; Region: PRD; pfam00874
866913001343	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866913001344	active pocket/dimerization site; other site
866913001345	active site
866913001346	phosphorylation site [posttranslational modification]
866913001347	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
866913001348	active site
866913001349	phosphorylation site [posttranslational modification]
866913001350	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
866913001351	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
866913001352	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
866913001353	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
866913001354	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
866913001355	hypothetical protein; Provisional; Region: PRK09956
866913001356	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
866913001357	EamA-like transporter family; Region: EamA; pfam00892
866913001358	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866913001359	EamA-like transporter family; Region: EamA; pfam00892
866913001360	magnesium transport protein MgtC; Provisional; Region: PRK15385
866913001361	MgtC family; Region: MgtC; pfam02308
866913001362	magnesium-transporting ATPase; Provisional; Region: PRK15122
866913001363	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
866913001364	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866913001365	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
866913001366	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913001367	motif II; other site
866913001368	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
866913001369	Isochorismatase family; Region: Isochorismatase; pfam00857
866913001370	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
866913001371	catalytic triad [active]
866913001372	dimer interface [polypeptide binding]; other site
866913001373	conserved cis-peptide bond; other site
866913001374	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
866913001375	DNA binding site [nucleotide binding]
866913001376	autotransport protein MisL; Provisional; Region: PRK15313
866913001377	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
866913001378	Autotransporter beta-domain; Region: Autotransporter; pfam03797
866913001379	Virulence protein [General function prediction only]; Region: COG3943
866913001380	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
866913001381	Methyltransferase domain; Region: Methyltransf_27; pfam13708
866913001382	putative transporter; Provisional; Region: PRK11462
866913001383	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
866913001384	putative alpha-glucosidase; Provisional; Region: PRK10658
866913001385	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
866913001386	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
866913001387	active site
866913001388	homotrimer interface [polypeptide binding]; other site
866913001389	catalytic site [active]
866913001390	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
866913001391	AsmA family; Region: AsmA; pfam05170
866913001392	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
866913001393	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
866913001394	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
866913001395	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
866913001396	generic binding surface II; other site
866913001397	ssDNA binding site; other site
866913001398	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913001399	ATP binding site [chemical binding]; other site
866913001400	putative Mg++ binding site [ion binding]; other site
866913001401	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913001402	nucleotide binding region [chemical binding]; other site
866913001403	ATP-binding site [chemical binding]; other site
866913001404	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
866913001405	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866913001406	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
866913001407	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
866913001408	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866913001409	Zn2+ binding site [ion binding]; other site
866913001410	Mg2+ binding site [ion binding]; other site
866913001411	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
866913001412	synthetase active site [active]
866913001413	NTP binding site [chemical binding]; other site
866913001414	metal binding site [ion binding]; metal-binding site
866913001415	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
866913001416	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
866913001417	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
866913001418	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
866913001419	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
866913001420	catalytic site [active]
866913001421	G-X2-G-X-G-K; other site
866913001422	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
866913001423	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
866913001424	nucleotide binding pocket [chemical binding]; other site
866913001425	K-X-D-G motif; other site
866913001426	catalytic site [active]
866913001427	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
866913001428	Predicted membrane protein [Function unknown]; Region: COG2860
866913001429	UPF0126 domain; Region: UPF0126; pfam03458
866913001430	UPF0126 domain; Region: UPF0126; pfam03458
866913001431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866913001432	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913001433	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913001434	dimerization interface [polypeptide binding]; other site
866913001435	LysR substrate binding domain; Region: LysR_substrate; pfam03466
866913001436	hypothetical protein; Provisional; Region: PRK11820
866913001437	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
866913001438	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
866913001439	ribonuclease PH; Reviewed; Region: rph; PRK00173
866913001440	Ribonuclease PH; Region: RNase_PH_bact; cd11362
866913001441	hexamer interface [polypeptide binding]; other site
866913001442	active site
866913001443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913001444	active site
866913001445	division inhibitor protein; Provisional; Region: slmA; PRK09480
866913001446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913001447	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
866913001448	trimer interface [polypeptide binding]; other site
866913001449	active site
866913001450	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
866913001451	Flavoprotein; Region: Flavoprotein; pfam02441
866913001452	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
866913001453	hypothetical protein; Reviewed; Region: PRK00024
866913001454	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
866913001455	MPN+ (JAMM) motif; other site
866913001456	Zinc-binding site [ion binding]; other site
866913001457	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
866913001458	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
866913001459	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
866913001460	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
866913001461	DNA binding site [nucleotide binding]
866913001462	catalytic residue [active]
866913001463	H2TH interface [polypeptide binding]; other site
866913001464	putative catalytic residues [active]
866913001465	turnover-facilitating residue; other site
866913001466	intercalation triad [nucleotide binding]; other site
866913001467	8OG recognition residue [nucleotide binding]; other site
866913001468	putative reading head residues; other site
866913001469	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
866913001470	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
866913001471	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
866913001472	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
866913001473	active site
866913001474	(T/H)XGH motif; other site
866913001475	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
866913001476	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
866913001477	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866913001478	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
866913001479	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
866913001480	putative active site [active]
866913001481	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866913001482	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
866913001483	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
866913001484	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913001485	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
866913001486	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
866913001487	putative ADP-binding pocket [chemical binding]; other site
866913001488	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
866913001489	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
866913001490	Ligand binding site; other site
866913001491	metal-binding site
866913001492	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
866913001493	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
866913001494	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
866913001495	Ligand binding site; other site
866913001496	metal-binding site
866913001497	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
866913001498	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
866913001499	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
866913001500	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
866913001501	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
866913001502	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
866913001503	O-antigen ligase RfaL; Provisional; Region: PRK15487
866913001504	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
866913001505	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
866913001506	putative active site [active]
866913001507	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
866913001508	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
866913001509	putative active site [active]
866913001510	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
866913001511	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
866913001512	NADP binding site [chemical binding]; other site
866913001513	homopentamer interface [polypeptide binding]; other site
866913001514	substrate binding site [chemical binding]; other site
866913001515	active site
866913001516	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
866913001517	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
866913001518	substrate-cofactor binding pocket; other site
866913001519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913001520	catalytic residue [active]
866913001521	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
866913001522	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
866913001523	NAD(P) binding site [chemical binding]; other site
866913001524	putative glycosyl transferase; Provisional; Region: PRK10073
866913001525	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866913001526	active site
866913001527	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
866913001528	NodB motif; other site
866913001529	putative active site [active]
866913001530	putative catalytic site [active]
866913001531	Zn binding site [ion binding]; other site
866913001532	AmiB activator; Provisional; Region: PRK11637
866913001533	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
866913001534	Peptidase family M23; Region: Peptidase_M23; pfam01551
866913001535	phosphoglyceromutase; Provisional; Region: PRK05434
866913001536	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
866913001537	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866913001538	active site residue [active]
866913001539	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
866913001540	GSH binding site [chemical binding]; other site
866913001541	catalytic residues [active]
866913001542	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
866913001543	SecA binding site; other site
866913001544	Preprotein binding site; other site
866913001545	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
866913001546	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
866913001547	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
866913001548	serine acetyltransferase; Provisional; Region: cysE; PRK11132
866913001549	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
866913001550	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
866913001551	trimer interface [polypeptide binding]; other site
866913001552	active site
866913001553	substrate binding site [chemical binding]; other site
866913001554	CoA binding site [chemical binding]; other site
866913001555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001556	D-galactonate transporter; Region: 2A0114; TIGR00893
866913001557	putative substrate translocation pore; other site
866913001558	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
866913001559	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
866913001560	active site pocket [active]
866913001561	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866913001562	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913001563	DNA binding site [nucleotide binding]
866913001564	domain linker motif; other site
866913001565	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
866913001566	putative dimerization interface [polypeptide binding]; other site
866913001567	putative ligand binding site [chemical binding]; other site
866913001568	putative rRNA methylase; Provisional; Region: PRK10358
866913001569	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
866913001570	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
866913001571	active site
866913001572	substrate binding site [chemical binding]; other site
866913001573	FMN binding site [chemical binding]; other site
866913001574	putative catalytic residues [active]
866913001575	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
866913001576	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913001577	DNA-binding site [nucleotide binding]; DNA binding site
866913001578	FCD domain; Region: FCD; pfam07729
866913001579	L-lactate permease; Provisional; Region: PRK10420
866913001580	glycolate transporter; Provisional; Region: PRK09695
866913001581	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
866913001582	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
866913001583	trimer interface [polypeptide binding]; other site
866913001584	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
866913001585	Haemagglutinin; Region: HIM; pfam05662
866913001586	Haemagglutinin; Region: HIM; pfam05662
866913001587	YadA-like C-terminal region; Region: YadA; pfam03895
866913001588	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
866913001589	hypothetical protein; Provisional; Region: PRK11020
866913001590	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
866913001591	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
866913001592	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
866913001593	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
866913001594	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
866913001595	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
866913001596	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
866913001597	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
866913001598	active site
866913001599	P-loop; other site
866913001600	phosphorylation site [posttranslational modification]
866913001601	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913001602	active site
866913001603	phosphorylation site [posttranslational modification]
866913001604	putative glutathione S-transferase; Provisional; Region: PRK10357
866913001605	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
866913001606	putative C-terminal domain interface [polypeptide binding]; other site
866913001607	putative GSH binding site (G-site) [chemical binding]; other site
866913001608	putative dimer interface [polypeptide binding]; other site
866913001609	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
866913001610	dimer interface [polypeptide binding]; other site
866913001611	N-terminal domain interface [polypeptide binding]; other site
866913001612	putative substrate binding pocket (H-site) [chemical binding]; other site
866913001613	selenocysteine synthase; Provisional; Region: PRK04311
866913001614	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
866913001615	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
866913001616	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913001617	catalytic residue [active]
866913001618	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
866913001619	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
866913001620	G1 box; other site
866913001621	putative GEF interaction site [polypeptide binding]; other site
866913001622	GTP/Mg2+ binding site [chemical binding]; other site
866913001623	Switch I region; other site
866913001624	G2 box; other site
866913001625	G3 box; other site
866913001626	Switch II region; other site
866913001627	G4 box; other site
866913001628	G5 box; other site
866913001629	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
866913001630	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
866913001631	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
866913001632	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
866913001633	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866913001634	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913001635	nucleotide binding site [chemical binding]; other site
866913001636	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
866913001637	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866913001638	NAD(P) binding site [chemical binding]; other site
866913001639	catalytic residues [active]
866913001640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
866913001641	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
866913001642	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
866913001643	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
866913001644	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913001645	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
866913001646	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
866913001647	intersubunit interface [polypeptide binding]; other site
866913001648	active site
866913001649	Zn2+ binding site [ion binding]; other site
866913001650	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
866913001651	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
866913001652	AP (apurinic/apyrimidinic) site pocket; other site
866913001653	DNA interaction; other site
866913001654	Metal-binding active site; metal-binding site
866913001655	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
866913001656	active site
866913001657	dimer interface [polypeptide binding]; other site
866913001658	magnesium binding site [ion binding]; other site
866913001659	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
866913001660	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
866913001661	putative N- and C-terminal domain interface [polypeptide binding]; other site
866913001662	putative active site [active]
866913001663	MgATP binding site [chemical binding]; other site
866913001664	catalytic site [active]
866913001665	metal binding site [ion binding]; metal-binding site
866913001666	putative xylulose binding site [chemical binding]; other site
866913001667	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
866913001668	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
866913001669	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
866913001670	DctM-like transporters; Region: DctM; pfam06808
866913001671	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
866913001672	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
866913001673	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
866913001674	Transcriptional regulator [Transcription]; Region: IclR; COG1414
866913001675	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
866913001676	Bacterial transcriptional regulator; Region: IclR; pfam01614
866913001677	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
866913001678	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
866913001679	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913001680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913001681	homodimer interface [polypeptide binding]; other site
866913001682	catalytic residue [active]
866913001683	alpha-amylase; Reviewed; Region: malS; PRK09505
866913001684	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
866913001685	active site
866913001686	catalytic site [active]
866913001687	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
866913001688	hypothetical protein; Provisional; Region: PRK10356
866913001689	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
866913001690	putative dimerization interface [polypeptide binding]; other site
866913001691	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866913001692	putative ligand binding site [chemical binding]; other site
866913001693	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913001694	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913001695	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913001696	xylose isomerase; Provisional; Region: PRK05474
866913001697	xylose isomerase; Region: xylose_isom_A; TIGR02630
866913001698	xylulokinase; Provisional; Region: PRK15027
866913001699	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
866913001700	N- and C-terminal domain interface [polypeptide binding]; other site
866913001701	active site
866913001702	MgATP binding site [chemical binding]; other site
866913001703	catalytic site [active]
866913001704	metal binding site [ion binding]; metal-binding site
866913001705	xylulose binding site [chemical binding]; other site
866913001706	homodimer interface [polypeptide binding]; other site
866913001707	Predicted membrane protein [Function unknown]; Region: COG4682
866913001708	yiaA/B two helix domain; Region: YiaAB; cl01759
866913001709	yiaA/B two helix domain; Region: YiaAB; cl01759
866913001710	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
866913001711	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866913001712	YsaB-like lipoprotein; Region: YsaB; pfam13983
866913001713	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
866913001714	dimer interface [polypeptide binding]; other site
866913001715	motif 1; other site
866913001716	active site
866913001717	motif 2; other site
866913001718	motif 3; other site
866913001719	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
866913001720	DALR anticodon binding domain; Region: DALR_1; pfam05746
866913001721	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866913001722	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913001723	Coenzyme A binding pocket [chemical binding]; other site
866913001724	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
866913001725	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
866913001726	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866913001727	DNA-binding site [nucleotide binding]; DNA binding site
866913001728	RNA-binding motif; other site
866913001729	Predicted transcriptional regulator [Transcription]; Region: COG2944
866913001730	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913001731	salt bridge; other site
866913001732	non-specific DNA binding site [nucleotide binding]; other site
866913001733	sequence-specific DNA binding site [nucleotide binding]; other site
866913001734	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
866913001735	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
866913001736	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
866913001737	dimerization interface [polypeptide binding]; other site
866913001738	ligand binding site [chemical binding]; other site
866913001739	NADP binding site [chemical binding]; other site
866913001740	catalytic site [active]
866913001741	putative outer membrane lipoprotein; Provisional; Region: PRK10510
866913001742	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
866913001743	ligand binding site [chemical binding]; other site
866913001744	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
866913001745	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
866913001746	molybdopterin cofactor binding site [chemical binding]; other site
866913001747	substrate binding site [chemical binding]; other site
866913001748	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
866913001749	molybdopterin cofactor binding site; other site
866913001750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913001751	Coenzyme A binding pocket [chemical binding]; other site
866913001752	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
866913001753	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
866913001754	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
866913001755	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
866913001756	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913001757	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913001758	long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207
866913001759	PapC N-terminal domain; Region: PapC_N; pfam13954
866913001760	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913001761	PapC C-terminal domain; Region: PapC_C; pfam13953
866913001762	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
866913001763	phosphoethanolamine transferase; Provisional; Region: PRK11560
866913001764	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
866913001765	Sulfatase; Region: Sulfatase; pfam00884
866913001766	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866913001767	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913001768	DNA binding site [nucleotide binding]
866913001769	domain linker motif; other site
866913001770	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
866913001771	putative dimerization interface [polypeptide binding]; other site
866913001772	putative ligand binding site [chemical binding]; other site
866913001773	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
866913001774	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
866913001775	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
866913001776	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
866913001777	peptide binding site [polypeptide binding]; other site
866913001778	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866913001779	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913001780	dimer interface [polypeptide binding]; other site
866913001781	conserved gate region; other site
866913001782	putative PBP binding loops; other site
866913001783	ABC-ATPase subunit interface; other site
866913001784	dipeptide transporter; Provisional; Region: PRK10913
866913001785	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
866913001786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913001787	dimer interface [polypeptide binding]; other site
866913001788	conserved gate region; other site
866913001789	putative PBP binding loops; other site
866913001790	ABC-ATPase subunit interface; other site
866913001791	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
866913001792	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
866913001793	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
866913001794	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
866913001795	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
866913001796	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
866913001797	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
866913001798	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
866913001799	cell division protein; Provisional; Region: PRK10037
866913001800	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
866913001801	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913001802	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
866913001803	DXD motif; other site
866913001804	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913001805	PilZ domain; Region: PilZ; pfam07238
866913001806	cellulose synthase regulator protein; Provisional; Region: PRK11114
866913001807	endo-1,4-D-glucanase; Provisional; Region: PRK11097
866913001808	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
866913001809	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
866913001810	TPR motif; other site
866913001811	binding surface
866913001812	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866913001813	TPR motif; other site
866913001814	binding surface
866913001815	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866913001816	binding surface
866913001817	TPR motif; other site
866913001818	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
866913001819	putative diguanylate cyclase; Provisional; Region: PRK13561
866913001820	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913001821	metal binding site [ion binding]; metal-binding site
866913001822	active site
866913001823	I-site; other site
866913001824	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913001825	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
866913001826	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866913001827	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
866913001828	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
866913001829	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913001830	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
866913001831	substrate binding site [chemical binding]; other site
866913001832	ATP binding site [chemical binding]; other site
866913001833	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913001834	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
866913001835	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
866913001836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001837	metabolite-proton symporter; Region: 2A0106; TIGR00883
866913001838	putative substrate translocation pore; other site
866913001839	inner membrane protein YhjD; Region: TIGR00766
866913001840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913001841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913001842	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
866913001843	putative effector binding pocket; other site
866913001844	putative dimerization interface [polypeptide binding]; other site
866913001845	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866913001846	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913001847	DNA binding residues [nucleotide binding]
866913001848	dimerization interface [polypeptide binding]; other site
866913001849	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
866913001850	catalytic residue [active]
866913001851	trehalase; Provisional; Region: treF; PRK13270
866913001852	Trehalase; Region: Trehalase; pfam01204
866913001853	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866913001854	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913001855	DNA-binding site [nucleotide binding]; DNA binding site
866913001856	UTRA domain; Region: UTRA; pfam07702
866913001857	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
866913001858	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
866913001859	putative active site [active]
866913001860	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866913001861	dimer interface [polypeptide binding]; other site
866913001862	active site
866913001863	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
866913001864	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913001865	substrate binding site [chemical binding]; other site
866913001866	ATP binding site [chemical binding]; other site
866913001867	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
866913001868	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
866913001869	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
866913001870	active site
866913001871	homodimer interface [polypeptide binding]; other site
866913001872	homotetramer interface [polypeptide binding]; other site
866913001873	glutathione reductase; Validated; Region: PRK06116
866913001874	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913001875	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913001876	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866913001877	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
866913001878	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
866913001879	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866913001880	active site
866913001881	oligopeptidase A; Provisional; Region: PRK10911
866913001882	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
866913001883	active site
866913001884	Zn binding site [ion binding]; other site
866913001885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913001886	S-adenosylmethionine binding site [chemical binding]; other site
866913001887	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
866913001888	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001889	putative substrate translocation pore; other site
866913001890	POT family; Region: PTR2; pfam00854
866913001891	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866913001892	Ligand Binding Site [chemical binding]; other site
866913001893	universal stress protein UspB; Provisional; Region: PRK04960
866913001894	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
866913001895	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
866913001896	Predicted flavoproteins [General function prediction only]; Region: COG2081
866913001897	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913001898	HlyD family secretion protein; Region: HlyD; pfam00529
866913001899	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913001900	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913001901	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866913001902	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
866913001903	Walker A/P-loop; other site
866913001904	ATP binding site [chemical binding]; other site
866913001905	Q-loop/lid; other site
866913001906	ABC transporter signature motif; other site
866913001907	Walker B; other site
866913001908	D-loop; other site
866913001909	H-loop/switch region; other site
866913001910	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866913001911	Walker A/P-loop; other site
866913001912	ATP binding site [chemical binding]; other site
866913001913	Q-loop/lid; other site
866913001914	ABC transporter signature motif; other site
866913001915	Walker B; other site
866913001916	D-loop; other site
866913001917	H-loop/switch region; other site
866913001918	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866913001919	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
866913001920	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866913001921	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866913001922	nickel responsive regulator; Provisional; Region: PRK02967
866913001923	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
866913001924	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
866913001925	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
866913001926	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
866913001927	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866913001928	major facilitator superfamily transporter; Provisional; Region: PRK05122
866913001929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913001930	putative substrate translocation pore; other site
866913001931	hypothetical protein; Provisional; Region: PRK11615
866913001932	hypothetical protein; Provisional; Region: PRK11212
866913001933	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
866913001934	CPxP  motif; other site
866913001935	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
866913001936	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
866913001937	dimer interface [polypeptide binding]; other site
866913001938	ligand binding site [chemical binding]; other site
866913001939	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913001940	dimerization interface [polypeptide binding]; other site
866913001941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913001942	dimer interface [polypeptide binding]; other site
866913001943	putative CheW interface [polypeptide binding]; other site
866913001944	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
866913001945	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866913001946	metal-binding site [ion binding]
866913001947	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866913001948	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866913001949	Predicted membrane protein [Function unknown]; Region: COG3714
866913001950	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
866913001951	hypothetical protein; Provisional; Region: PRK10910
866913001952	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
866913001953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913001954	S-adenosylmethionine binding site [chemical binding]; other site
866913001955	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
866913001956	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
866913001957	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
866913001958	P loop; other site
866913001959	GTP binding site [chemical binding]; other site
866913001960	cell division protein FtsE; Provisional; Region: PRK10908
866913001961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913001962	Walker A/P-loop; other site
866913001963	ATP binding site [chemical binding]; other site
866913001964	Q-loop/lid; other site
866913001965	ABC transporter signature motif; other site
866913001966	Walker B; other site
866913001967	D-loop; other site
866913001968	H-loop/switch region; other site
866913001969	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
866913001970	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
866913001971	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
866913001972	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866913001973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866913001974	DNA binding residues [nucleotide binding]
866913001975	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
866913001976	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
866913001977	dimerization interface [polypeptide binding]; other site
866913001978	ligand binding site [chemical binding]; other site
866913001979	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
866913001980	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
866913001981	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
866913001982	dimerization interface [polypeptide binding]; other site
866913001983	ligand binding site [chemical binding]; other site
866913001984	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866913001985	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
866913001986	TM-ABC transporter signature motif; other site
866913001987	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
866913001988	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
866913001989	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
866913001990	TM-ABC transporter signature motif; other site
866913001991	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
866913001992	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
866913001993	Walker A/P-loop; other site
866913001994	ATP binding site [chemical binding]; other site
866913001995	Q-loop/lid; other site
866913001996	ABC transporter signature motif; other site
866913001997	Walker B; other site
866913001998	D-loop; other site
866913001999	H-loop/switch region; other site
866913002000	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
866913002001	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
866913002002	Walker A/P-loop; other site
866913002003	ATP binding site [chemical binding]; other site
866913002004	Q-loop/lid; other site
866913002005	ABC transporter signature motif; other site
866913002006	Walker B; other site
866913002007	D-loop; other site
866913002008	H-loop/switch region; other site
866913002009	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
866913002010	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
866913002011	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
866913002012	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866913002013	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866913002014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913002015	dimer interface [polypeptide binding]; other site
866913002016	conserved gate region; other site
866913002017	putative PBP binding loops; other site
866913002018	ABC-ATPase subunit interface; other site
866913002019	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866913002020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913002021	dimer interface [polypeptide binding]; other site
866913002022	conserved gate region; other site
866913002023	ABC-ATPase subunit interface; other site
866913002024	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
866913002025	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
866913002026	Walker A/P-loop; other site
866913002027	ATP binding site [chemical binding]; other site
866913002028	Q-loop/lid; other site
866913002029	ABC transporter signature motif; other site
866913002030	Walker B; other site
866913002031	D-loop; other site
866913002032	H-loop/switch region; other site
866913002033	TOBE domain; Region: TOBE_2; pfam08402
866913002034	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
866913002035	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
866913002036	putative active site [active]
866913002037	catalytic site [active]
866913002038	putative metal binding site [ion binding]; other site
866913002039	hypothetical protein; Provisional; Region: PRK10350
866913002040	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
866913002041	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
866913002042	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
866913002043	active site
866913002044	substrate binding pocket [chemical binding]; other site
866913002045	homodimer interaction site [polypeptide binding]; other site
866913002046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
866913002047	Protein of unknown function, DUF606; Region: DUF606; pfam04657
866913002048	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
866913002049	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913002050	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866913002051	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913002052	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866913002053	substrate binding site [chemical binding]; other site
866913002054	dimer interface [polypeptide binding]; other site
866913002055	ATP binding site [chemical binding]; other site
866913002056	putative acetyltransferase YhhY; Provisional; Region: PRK10140
866913002057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913002058	Coenzyme A binding pocket [chemical binding]; other site
866913002059	putative oxidoreductase; Provisional; Region: PRK10206
866913002060	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866913002061	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866913002062	Pirin-related protein [General function prediction only]; Region: COG1741
866913002063	Pirin; Region: Pirin; pfam02678
866913002064	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
866913002065	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913002066	DNA binding site [nucleotide binding]
866913002067	domain linker motif; other site
866913002068	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
866913002069	putative ligand binding site [chemical binding]; other site
866913002070	putative dimerization interface [polypeptide binding]; other site
866913002071	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
866913002072	ATP-binding site [chemical binding]; other site
866913002073	Gluconate-6-phosphate binding site [chemical binding]; other site
866913002074	low affinity gluconate transporter; Provisional; Region: PRK10472
866913002075	gluconate transporter; Region: gntP; TIGR00791
866913002076	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
866913002077	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866913002078	glycogen branching enzyme; Provisional; Region: PRK05402
866913002079	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
866913002080	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
866913002081	active site
866913002082	catalytic site [active]
866913002083	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
866913002084	glycogen debranching enzyme; Provisional; Region: PRK03705
866913002085	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
866913002086	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
866913002087	active site
866913002088	catalytic site [active]
866913002089	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
866913002090	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
866913002091	ligand binding site; other site
866913002092	oligomer interface; other site
866913002093	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
866913002094	dimer interface [polypeptide binding]; other site
866913002095	N-terminal domain interface [polypeptide binding]; other site
866913002096	sulfate 1 binding site; other site
866913002097	glycogen synthase; Provisional; Region: glgA; PRK00654
866913002098	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
866913002099	ADP-binding pocket [chemical binding]; other site
866913002100	homodimer interface [polypeptide binding]; other site
866913002101	glycogen phosphorylase; Provisional; Region: PRK14986
866913002102	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
866913002103	homodimer interface [polypeptide binding]; other site
866913002104	active site pocket [active]
866913002105	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
866913002106	Transcriptional regulator [Transcription]; Region: IclR; COG1414
866913002107	Bacterial transcriptional regulator; Region: IclR; pfam01614
866913002108	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866913002109	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
866913002110	inhibitor site; inhibition site
866913002111	active site
866913002112	dimer interface [polypeptide binding]; other site
866913002113	catalytic residue [active]
866913002114	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
866913002115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913002116	D-galactonate transporter; Region: 2A0114; TIGR00893
866913002117	putative substrate translocation pore; other site
866913002118	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
866913002119	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
866913002120	dimer interface [polypeptide binding]; other site
866913002121	active site
866913002122	metal binding site [ion binding]; metal-binding site
866913002123	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
866913002124	hypothetical protein; Provisional; Region: PRK09781
866913002125	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
866913002126	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
866913002127	active site residue [active]
866913002128	intramembrane serine protease GlpG; Provisional; Region: PRK10907
866913002129	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
866913002130	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
866913002131	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
866913002132	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866913002133	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913002134	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
866913002135	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
866913002136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913002137	Walker A motif; other site
866913002138	ATP binding site [chemical binding]; other site
866913002139	Walker B motif; other site
866913002140	arginine finger; other site
866913002141	TROVE domain; Region: TROVE; pfam05731
866913002142	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
866913002143	hypothetical protein; Reviewed; Region: PRK09588
866913002144	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
866913002145	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
866913002146	putative active site [active]
866913002147	adenylation catalytic residue [active]
866913002148	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
866913002149	transcriptional regulator MalT; Provisional; Region: PRK04841
866913002150	AAA ATPase domain; Region: AAA_16; pfam13191
866913002151	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913002152	DNA binding residues [nucleotide binding]
866913002153	dimerization interface [polypeptide binding]; other site
866913002154	maltodextrin phosphorylase; Provisional; Region: PRK14985
866913002155	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
866913002156	homodimer interface [polypeptide binding]; other site
866913002157	active site pocket [active]
866913002158	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
866913002159	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
866913002160	high-affinity gluconate transporter; Provisional; Region: PRK14984
866913002161	gluconate transporter; Region: gntP; TIGR00791
866913002162	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
866913002163	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
866913002164	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
866913002165	DNA utilization protein GntX; Provisional; Region: PRK11595
866913002166	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913002167	active site
866913002168	carboxylesterase BioH; Provisional; Region: PRK10349
866913002169	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
866913002170	hypothetical protein; Provisional; Region: PRK09956
866913002171	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
866913002172	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
866913002173	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
866913002174	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
866913002175	G1 box; other site
866913002176	GTP/Mg2+ binding site [chemical binding]; other site
866913002177	Switch I region; other site
866913002178	G2 box; other site
866913002179	G3 box; other site
866913002180	Switch II region; other site
866913002181	G4 box; other site
866913002182	G5 box; other site
866913002183	Nucleoside recognition; Region: Gate; pfam07670
866913002184	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
866913002185	Nucleoside recognition; Region: Gate; pfam07670
866913002186	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
866913002187	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
866913002188	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
866913002189	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
866913002190	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
866913002191	RNA binding site [nucleotide binding]; other site
866913002192	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
866913002193	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
866913002194	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
866913002195	osmolarity response regulator; Provisional; Region: ompR; PRK09468
866913002196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913002197	active site
866913002198	phosphorylation site [posttranslational modification]
866913002199	intermolecular recognition site; other site
866913002200	dimerization interface [polypeptide binding]; other site
866913002201	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913002202	DNA binding site [nucleotide binding]
866913002203	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
866913002204	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913002205	dimerization interface [polypeptide binding]; other site
866913002206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913002207	dimer interface [polypeptide binding]; other site
866913002208	phosphorylation site [posttranslational modification]
866913002209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913002210	ATP binding site [chemical binding]; other site
866913002211	G-X-G motif; other site
866913002212	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
866913002213	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
866913002214	active site
866913002215	substrate-binding site [chemical binding]; other site
866913002216	metal-binding site [ion binding]
866913002217	ATP binding site [chemical binding]; other site
866913002218	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
866913002219	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
866913002220	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
866913002221	dimerization interface [polypeptide binding]; other site
866913002222	domain crossover interface; other site
866913002223	redox-dependent activation switch; other site
866913002224	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913002225	RNA binding surface [nucleotide binding]; other site
866913002226	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
866913002227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913002228	motif II; other site
866913002229	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
866913002230	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
866913002231	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
866913002232	ADP-ribose binding site [chemical binding]; other site
866913002233	dimer interface [polypeptide binding]; other site
866913002234	active site
866913002235	nudix motif; other site
866913002236	metal binding site [ion binding]; metal-binding site
866913002237	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
866913002238	Transglycosylase; Region: Transgly; pfam00912
866913002239	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866913002240	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
866913002241	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
866913002242	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
866913002243	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
866913002244	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
866913002245	shikimate kinase; Reviewed; Region: aroK; PRK00131
866913002246	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
866913002247	ADP binding site [chemical binding]; other site
866913002248	magnesium binding site [ion binding]; other site
866913002249	putative shikimate binding site; other site
866913002250	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
866913002251	active site
866913002252	dimer interface [polypeptide binding]; other site
866913002253	metal binding site [ion binding]; metal-binding site
866913002254	cell division protein DamX; Validated; Region: PRK10905
866913002255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
866913002256	DNA adenine methylase; Provisional; Region: PRK10904
866913002257	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866913002258	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
866913002259	substrate binding site [chemical binding]; other site
866913002260	hexamer interface [polypeptide binding]; other site
866913002261	metal binding site [ion binding]; metal-binding site
866913002262	phosphoglycolate phosphatase; Provisional; Region: PRK13222
866913002263	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913002264	motif II; other site
866913002265	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
866913002266	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
866913002267	active site
866913002268	HIGH motif; other site
866913002269	dimer interface [polypeptide binding]; other site
866913002270	KMSKS motif; other site
866913002271	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
866913002272	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913002273	Autotransporter beta-domain; Region: Autotransporter; pfam03797
866913002274	siroheme synthase; Provisional; Region: cysG; PRK10637
866913002275	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
866913002276	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
866913002277	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
866913002278	active site
866913002279	SAM binding site [chemical binding]; other site
866913002280	homodimer interface [polypeptide binding]; other site
866913002281	nitrite transporter NirC; Provisional; Region: PRK11562
866913002282	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
866913002283	nitrite reductase subunit NirD; Provisional; Region: PRK14989
866913002284	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913002285	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
866913002286	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
866913002287	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
866913002288	putative transporter; Provisional; Region: PRK03699
866913002289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913002290	putative substrate translocation pore; other site
866913002291	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
866913002292	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
866913002293	substrate binding site [chemical binding]; other site
866913002294	hypothetical protein; Provisional; Region: PRK10204
866913002295	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
866913002296	cell filamentation protein Fic; Provisional; Region: PRK10347
866913002297	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
866913002298	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
866913002299	glutamine binding [chemical binding]; other site
866913002300	catalytic triad [active]
866913002301	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
866913002302	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866913002303	inhibitor-cofactor binding pocket; inhibition site
866913002304	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913002305	catalytic residue [active]
866913002306	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
866913002307	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
866913002308	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
866913002309	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
866913002310	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866913002311	ligand binding site [chemical binding]; other site
866913002312	flexible hinge region; other site
866913002313	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
866913002314	putative switch regulator; other site
866913002315	non-specific DNA interactions [nucleotide binding]; other site
866913002316	DNA binding site [nucleotide binding]
866913002317	sequence specific DNA binding site [nucleotide binding]; other site
866913002318	putative cAMP binding site [chemical binding]; other site
866913002319	hypothetical protein; Provisional; Region: PRK10738
866913002320	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
866913002321	active site
866913002322	hypothetical protein; Provisional; Region: PRK04966
866913002323	putative hydrolase; Provisional; Region: PRK10985
866913002324	SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755
866913002325	putative monooxygenase; Provisional; Region: PRK11118
866913002326	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
866913002327	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913002328	Walker A/P-loop; other site
866913002329	ATP binding site [chemical binding]; other site
866913002330	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913002331	ABC transporter signature motif; other site
866913002332	Walker B; other site
866913002333	D-loop; other site
866913002334	ABC transporter; Region: ABC_tran_2; pfam12848
866913002335	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913002336	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
866913002337	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
866913002338	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
866913002339	TrkA-N domain; Region: TrkA_N; pfam02254
866913002340	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
866913002341	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
866913002342	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866913002343	phi X174 lysis protein; Provisional; Region: PRK02793
866913002344	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
866913002345	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
866913002346	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866913002347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
866913002348	YheO-like PAS domain; Region: PAS_6; pfam08348
866913002349	HTH domain; Region: HTH_22; pfam13309
866913002350	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
866913002351	sulfur relay protein TusC; Validated; Region: PRK00211
866913002352	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
866913002353	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
866913002354	S17 interaction site [polypeptide binding]; other site
866913002355	S8 interaction site; other site
866913002356	16S rRNA interaction site [nucleotide binding]; other site
866913002357	streptomycin interaction site [chemical binding]; other site
866913002358	23S rRNA interaction site [nucleotide binding]; other site
866913002359	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
866913002360	30S ribosomal protein S7; Validated; Region: PRK05302
866913002361	elongation factor G; Reviewed; Region: PRK00007
866913002362	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
866913002363	G1 box; other site
866913002364	putative GEF interaction site [polypeptide binding]; other site
866913002365	GTP/Mg2+ binding site [chemical binding]; other site
866913002366	Switch I region; other site
866913002367	G2 box; other site
866913002368	G3 box; other site
866913002369	Switch II region; other site
866913002370	G4 box; other site
866913002371	G5 box; other site
866913002372	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
866913002373	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
866913002374	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
866913002375	elongation factor Tu; Reviewed; Region: PRK00049
866913002376	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
866913002377	G1 box; other site
866913002378	GEF interaction site [polypeptide binding]; other site
866913002379	GTP/Mg2+ binding site [chemical binding]; other site
866913002380	Switch I region; other site
866913002381	G2 box; other site
866913002382	G3 box; other site
866913002383	Switch II region; other site
866913002384	G4 box; other site
866913002385	G5 box; other site
866913002386	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
866913002387	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
866913002388	Antibiotic Binding Site [chemical binding]; other site
866913002389	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
866913002390	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
866913002391	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
866913002392	heme binding site [chemical binding]; other site
866913002393	ferroxidase pore; other site
866913002394	ferroxidase diiron center [ion binding]; other site
866913002395	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
866913002396	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
866913002397	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
866913002398	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
866913002399	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
866913002400	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
866913002401	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
866913002402	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
866913002403	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
866913002404	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
866913002405	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
866913002406	protein-rRNA interface [nucleotide binding]; other site
866913002407	putative translocon binding site; other site
866913002408	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
866913002409	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
866913002410	G-X-X-G motif; other site
866913002411	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
866913002412	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
866913002413	23S rRNA interface [nucleotide binding]; other site
866913002414	5S rRNA interface [nucleotide binding]; other site
866913002415	putative antibiotic binding site [chemical binding]; other site
866913002416	L25 interface [polypeptide binding]; other site
866913002417	L27 interface [polypeptide binding]; other site
866913002418	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
866913002419	23S rRNA interface [nucleotide binding]; other site
866913002420	putative translocon interaction site; other site
866913002421	signal recognition particle (SRP54) interaction site; other site
866913002422	L23 interface [polypeptide binding]; other site
866913002423	trigger factor interaction site; other site
866913002424	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
866913002425	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
866913002426	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
866913002427	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
866913002428	RNA binding site [nucleotide binding]; other site
866913002429	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
866913002430	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
866913002431	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
866913002432	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
866913002433	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
866913002434	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
866913002435	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866913002436	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866913002437	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
866913002438	23S rRNA interface [nucleotide binding]; other site
866913002439	5S rRNA interface [nucleotide binding]; other site
866913002440	L27 interface [polypeptide binding]; other site
866913002441	L5 interface [polypeptide binding]; other site
866913002442	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
866913002443	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
866913002444	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
866913002445	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
866913002446	23S rRNA binding site [nucleotide binding]; other site
866913002447	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
866913002448	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
866913002449	SecY translocase; Region: SecY; pfam00344
866913002450	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
866913002451	30S ribosomal protein S13; Region: bact_S13; TIGR03631
866913002452	30S ribosomal protein S11; Validated; Region: PRK05309
866913002453	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
866913002454	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
866913002455	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913002456	RNA binding surface [nucleotide binding]; other site
866913002457	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
866913002458	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
866913002459	alphaNTD homodimer interface [polypeptide binding]; other site
866913002460	alphaNTD - beta interaction site [polypeptide binding]; other site
866913002461	alphaNTD - beta' interaction site [polypeptide binding]; other site
866913002462	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
866913002463	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
866913002464	hypothetical protein; Provisional; Region: PRK10203
866913002465	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
866913002466	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
866913002467	DNA binding residues [nucleotide binding]
866913002468	dimer interface [polypeptide binding]; other site
866913002469	metal binding site [ion binding]; metal-binding site
866913002470	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
866913002471	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
866913002472	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
866913002473	TrkA-N domain; Region: TrkA_N; pfam02254
866913002474	TrkA-C domain; Region: TrkA_C; pfam02080
866913002475	TrkA-N domain; Region: TrkA_N; pfam02254
866913002476	TrkA-C domain; Region: TrkA_C; pfam02080
866913002477	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
866913002478	putative RNA binding site [nucleotide binding]; other site
866913002479	16S rRNA methyltransferase B; Provisional; Region: PRK10901
866913002480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913002481	S-adenosylmethionine binding site [chemical binding]; other site
866913002482	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
866913002483	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
866913002484	putative active site [active]
866913002485	substrate binding site [chemical binding]; other site
866913002486	putative cosubstrate binding site; other site
866913002487	catalytic site [active]
866913002488	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
866913002489	substrate binding site [chemical binding]; other site
866913002490	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
866913002491	active site
866913002492	catalytic residues [active]
866913002493	metal binding site [ion binding]; metal-binding site
866913002494	hypothetical protein; Provisional; Region: PRK10736
866913002495	DNA protecting protein DprA; Region: dprA; TIGR00732
866913002496	hypothetical protein; Validated; Region: PRK03430
866913002497	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866913002498	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
866913002499	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866913002500	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866913002501	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
866913002502	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
866913002503	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
866913002504	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
866913002505	shikimate binding site; other site
866913002506	NAD(P) binding site [chemical binding]; other site
866913002507	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
866913002508	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
866913002509	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
866913002510	trimer interface [polypeptide binding]; other site
866913002511	putative metal binding site [ion binding]; other site
866913002512	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866913002513	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913002514	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866913002515	Coenzyme A binding pocket [chemical binding]; other site
866913002516	homoserine O-succinyltransferase; Provisional; Region: PRK05368
866913002517	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
866913002518	proposed active site lysine [active]
866913002519	conserved cys residue [active]
866913002520	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
866913002521	malate synthase A; Region: malate_syn_A; TIGR01344
866913002522	active site
866913002523	isocitrate lyase; Provisional; Region: PRK15063
866913002524	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
866913002525	tetramer interface [polypeptide binding]; other site
866913002526	active site
866913002527	Mg2+/Mn2+ binding site [ion binding]; other site
866913002528	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
866913002529	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
866913002530	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
866913002531	transcriptional repressor IclR; Provisional; Region: PRK11569
866913002532	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
866913002533	Bacterial transcriptional regulator; Region: IclR; pfam01614
866913002534	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
866913002535	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
866913002536	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
866913002537	substrate binding pocket [chemical binding]; other site
866913002538	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
866913002539	B12 binding site [chemical binding]; other site
866913002540	cobalt ligand [ion binding]; other site
866913002541	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
866913002542	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
866913002543	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
866913002544	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
866913002545	active site pocket [active]
866913002546	oxyanion hole [active]
866913002547	catalytic triad [active]
866913002548	active site nucleophile [active]
866913002549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
866913002550	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
866913002551	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913002552	RNA binding surface [nucleotide binding]; other site
866913002553	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
866913002554	probable active site [active]
866913002555	hypothetical protein; Provisional; Region: PRK10515
866913002556	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
866913002557	Sodium Bile acid symporter family; Region: SBF; pfam01758
866913002558	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
866913002559	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
866913002560	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
866913002561	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
866913002562	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
866913002563	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
866913002564	Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948
866913002565	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
866913002566	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
866913002567	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
866913002568	Ligand binding site; other site
866913002569	Putative Catalytic site; other site
866913002570	DXD motif; other site
866913002571	Predicted membrane protein [Function unknown]; Region: COG2246
866913002572	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
866913002573	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
866913002574	Phage protein D [General function prediction only]; Region: COG3500
866913002575	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
866913002576	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
866913002577	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
866913002578	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
866913002579	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
866913002580	Phage tail tube protein FII [General function prediction only]; Region: COG3498
866913002581	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
866913002582	Gp37 protein; Region: Gp37; pfam09646
866913002583	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866913002584	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913002585	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913002586	catalytic residue [active]
866913002587	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
866913002588	Mor transcription activator family; Region: Mor; pfam08765
866913002589	aspartate kinase III; Validated; Region: PRK09084
866913002590	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
866913002591	nucleotide binding site [chemical binding]; other site
866913002592	substrate binding site [chemical binding]; other site
866913002593	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
866913002594	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
866913002595	dimer interface [polypeptide binding]; other site
866913002596	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
866913002597	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
866913002598	active site
866913002599	dimer interface [polypeptide binding]; other site
866913002600	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
866913002601	dimer interface [polypeptide binding]; other site
866913002602	active site
866913002603	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
866913002604	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
866913002605	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
866913002606	Predicted membrane protein [Function unknown]; Region: COG3223
866913002607	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866913002608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913002609	dimer interface [polypeptide binding]; other site
866913002610	conserved gate region; other site
866913002611	putative PBP binding loops; other site
866913002612	ABC-ATPase subunit interface; other site
866913002613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913002614	dimer interface [polypeptide binding]; other site
866913002615	conserved gate region; other site
866913002616	putative PBP binding loops; other site
866913002617	ABC-ATPase subunit interface; other site
866913002618	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
866913002619	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
866913002620	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866913002621	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
866913002622	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
866913002623	Walker A/P-loop; other site
866913002624	ATP binding site [chemical binding]; other site
866913002625	Q-loop/lid; other site
866913002626	ABC transporter signature motif; other site
866913002627	Walker B; other site
866913002628	D-loop; other site
866913002629	H-loop/switch region; other site
866913002630	TOBE domain; Region: TOBE_2; pfam08402
866913002631	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
866913002632	trimer interface; other site
866913002633	sugar binding site [chemical binding]; other site
866913002634	maltose regulon periplasmic protein; Provisional; Region: PRK10564
866913002635	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
866913002636	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
866913002637	UbiA prenyltransferase family; Region: UbiA; pfam01040
866913002638	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
866913002639	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
866913002640	putative acyl-acceptor binding pocket; other site
866913002641	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
866913002642	LexA repressor; Validated; Region: PRK00215
866913002643	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
866913002644	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
866913002645	Catalytic site [active]
866913002646	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
866913002647	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
866913002648	hypothetical protein; Provisional; Region: PRK10428
866913002649	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866913002650	metal binding site 2 [ion binding]; metal-binding site
866913002651	putative DNA binding helix; other site
866913002652	metal binding site 1 [ion binding]; metal-binding site
866913002653	dimer interface [polypeptide binding]; other site
866913002654	structural Zn2+ binding site [ion binding]; other site
866913002655	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
866913002656	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
866913002657	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
866913002658	FMN binding site [chemical binding]; other site
866913002659	active site
866913002660	catalytic residues [active]
866913002661	substrate binding site [chemical binding]; other site
866913002662	phage shock protein G; Reviewed; Region: pspG; PRK09459
866913002663	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
866913002664	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
866913002665	NADP binding site [chemical binding]; other site
866913002666	dimer interface [polypeptide binding]; other site
866913002667	replicative DNA helicase; Provisional; Region: PRK08006
866913002668	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
866913002669	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
866913002670	Walker A motif; other site
866913002671	ATP binding site [chemical binding]; other site
866913002672	Walker B motif; other site
866913002673	DNA binding loops [nucleotide binding]
866913002674	alanine racemase; Reviewed; Region: alr; PRK00053
866913002675	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
866913002676	active site
866913002677	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866913002678	substrate binding site [chemical binding]; other site
866913002679	catalytic residues [active]
866913002680	dimer interface [polypeptide binding]; other site
866913002681	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
866913002682	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913002683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913002684	homodimer interface [polypeptide binding]; other site
866913002685	catalytic residue [active]
866913002686	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
866913002687	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913002688	active site
866913002689	motif I; other site
866913002690	motif II; other site
866913002691	Uncharacterized conserved protein [Function unknown]; Region: COG0432
866913002692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
866913002693	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
866913002694	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866913002695	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866913002696	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
866913002697	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
866913002698	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
866913002699	dimer interface [polypeptide binding]; other site
866913002700	ssDNA binding site [nucleotide binding]; other site
866913002701	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866913002702	hypothetical protein; Validated; Region: PRK09039
866913002703	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
866913002704	Outer membrane efflux protein; Region: OEP; pfam02321
866913002705	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
866913002706	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913002707	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913002708	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002709	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002710	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002711	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002712	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002713	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002714	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002715	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002716	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002717	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002718	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002719	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002720	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002721	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002722	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002723	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002724	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002725	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002726	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002727	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002728	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002729	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002730	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002731	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002732	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002733	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002734	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002735	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002736	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
866913002737	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002738	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002739	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002740	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002741	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002742	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002743	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002744	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913002745	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002746	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
866913002747	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002748	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913002749	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
866913002750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913002751	Walker A/P-loop; other site
866913002752	ATP binding site [chemical binding]; other site
866913002753	Q-loop/lid; other site
866913002754	ABC transporter signature motif; other site
866913002755	Walker B; other site
866913002756	D-loop; other site
866913002757	H-loop/switch region; other site
866913002758	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
866913002759	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
866913002760	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913002761	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
866913002762	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913002763	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
866913002764	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
866913002765	DNA binding residues [nucleotide binding]
866913002766	dimer interface [polypeptide binding]; other site
866913002767	[2Fe-2S] cluster binding site [ion binding]; other site
866913002768	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
866913002769	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
866913002770	putative C-terminal domain interface [polypeptide binding]; other site
866913002771	putative GSH binding site (G-site) [chemical binding]; other site
866913002772	putative dimer interface [polypeptide binding]; other site
866913002773	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
866913002774	putative N-terminal domain interface [polypeptide binding]; other site
866913002775	putative dimer interface [polypeptide binding]; other site
866913002776	putative substrate binding pocket (H-site) [chemical binding]; other site
866913002777	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
866913002778	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
866913002779	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
866913002780	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913002781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913002782	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
866913002783	putative dimerization interface [polypeptide binding]; other site
866913002784	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
866913002785	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
866913002786	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
866913002787	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
866913002788	Na binding site [ion binding]; other site
866913002789	Predicted membrane protein [Function unknown]; Region: COG3162
866913002790	acetyl-CoA synthetase; Provisional; Region: PRK00174
866913002791	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
866913002792	active site
866913002793	CoA binding site [chemical binding]; other site
866913002794	acyl-activating enzyme (AAE) consensus motif; other site
866913002795	AMP binding site [chemical binding]; other site
866913002796	acetate binding site [chemical binding]; other site
866913002797	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
866913002798	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
866913002799	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
866913002800	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
866913002801	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
866913002802	heme lyase subunit NrfE; Provisional; Region: PRK10369
866913002803	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
866913002804	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
866913002805	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
866913002806	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866913002807	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913002808	Sel1-like repeats; Region: SEL1; smart00671
866913002809	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913002810	molybdopterin cofactor binding site; other site
866913002811	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
866913002812	molybdopterin cofactor binding site; other site
866913002813	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913002814	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
866913002815	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913002816	Coenzyme A binding pocket [chemical binding]; other site
866913002817	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
866913002818	dimer interface [polypeptide binding]; other site
866913002819	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866913002820	hypothetical protein; Provisional; Region: PRK10220
866913002821	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
866913002822	PhnA protein; Region: PhnA; pfam03831
866913002823	proline/glycine betaine transporter; Provisional; Region: PRK10642
866913002824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913002825	putative substrate translocation pore; other site
866913002826	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
866913002827	sensor protein BasS/PmrB; Provisional; Region: PRK10755
866913002828	HAMP domain; Region: HAMP; pfam00672
866913002829	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913002830	dimer interface [polypeptide binding]; other site
866913002831	phosphorylation site [posttranslational modification]
866913002832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913002833	ATP binding site [chemical binding]; other site
866913002834	Mg2+ binding site [ion binding]; other site
866913002835	G-X-G motif; other site
866913002836	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
866913002837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913002838	active site
866913002839	phosphorylation site [posttranslational modification]
866913002840	intermolecular recognition site; other site
866913002841	dimerization interface [polypeptide binding]; other site
866913002842	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913002843	DNA binding site [nucleotide binding]
866913002844	putative metal dependent hydrolase; Provisional; Region: PRK11598
866913002845	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
866913002846	Sulfatase; Region: Sulfatase; pfam00884
866913002847	arginine:agmatin antiporter; Provisional; Region: PRK10644
866913002848	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
866913002849	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913002850	arginine decarboxylase; Provisional; Region: PRK15029
866913002851	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
866913002852	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
866913002853	homodimer interface [polypeptide binding]; other site
866913002854	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913002855	catalytic residue [active]
866913002856	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
866913002857	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
866913002858	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913002859	alpha-galactosidase; Provisional; Region: PRK15076
866913002860	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
866913002861	NAD binding site [chemical binding]; other site
866913002862	sugar binding site [chemical binding]; other site
866913002863	divalent metal binding site [ion binding]; other site
866913002864	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
866913002865	dimer interface [polypeptide binding]; other site
866913002866	melibiose:sodium symporter; Provisional; Region: PRK10429
866913002867	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
866913002868	fumarate hydratase; Provisional; Region: PRK15389
866913002869	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
866913002870	Fumarase C-terminus; Region: Fumerase_C; pfam05683
866913002871	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
866913002872	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
866913002873	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
866913002874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913002875	active site
866913002876	phosphorylation site [posttranslational modification]
866913002877	intermolecular recognition site; other site
866913002878	dimerization interface [polypeptide binding]; other site
866913002879	sensory histidine kinase DcuS; Provisional; Region: PRK11086
866913002880	PAS domain; Region: PAS; smart00091
866913002881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913002882	ATP binding site [chemical binding]; other site
866913002883	Mg2+ binding site [ion binding]; other site
866913002884	G-X-G motif; other site
866913002885	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
866913002886	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
866913002887	putative [Fe4-S4] binding site [ion binding]; other site
866913002888	putative molybdopterin cofactor binding site [chemical binding]; other site
866913002889	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
866913002890	putative molybdopterin cofactor binding site; other site
866913002891	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
866913002892	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
866913002893	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
866913002894	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
866913002895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
866913002896	SdiA-regulated; Region: SdiA-regulated; cd09971
866913002897	putative active site [active]
866913002898	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866913002899	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913002900	DNA binding residues [nucleotide binding]
866913002901	dimerization interface [polypeptide binding]; other site
866913002902	AraC family transcriptional regulator; Provisional; Region: PRK15186
866913002903	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913002904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
866913002905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913002906	Coenzyme A binding pocket [chemical binding]; other site
866913002907	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866913002908	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
866913002909	active site
866913002910	EthD domain; Region: EthD; pfam07110
866913002911	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
866913002912	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866913002913	DNA binding residues [nucleotide binding]
866913002914	putative dimer interface [polypeptide binding]; other site
866913002915	putative transcriptional regulator; Provisional; Region: PRK11640
866913002916	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913002917	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
866913002918	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
866913002919	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
866913002920	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
866913002921	DsbD alpha interface [polypeptide binding]; other site
866913002922	catalytic residues [active]
866913002923	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
866913002924	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
866913002925	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
866913002926	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
866913002927	Aspartase; Region: Aspartase; cd01357
866913002928	active sites [active]
866913002929	tetramer interface [polypeptide binding]; other site
866913002930	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
866913002931	putative transporter; Provisional; Region: PRK11021
866913002932	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
866913002933	oligomerisation interface [polypeptide binding]; other site
866913002934	mobile loop; other site
866913002935	roof hairpin; other site
866913002936	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
866913002937	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
866913002938	ring oligomerisation interface [polypeptide binding]; other site
866913002939	ATP/Mg binding site [chemical binding]; other site
866913002940	stacking interactions; other site
866913002941	hinge regions; other site
866913002942	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
866913002943	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
866913002944	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913002945	FeS/SAM binding site; other site
866913002946	elongation factor P; Validated; Region: PRK00529
866913002947	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
866913002948	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
866913002949	RNA binding site [nucleotide binding]; other site
866913002950	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
866913002951	RNA binding site [nucleotide binding]; other site
866913002952	Predicted small secreted protein [Function unknown]; Region: COG5510
866913002953	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
866913002954	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866913002955	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913002956	DNA binding residues [nucleotide binding]
866913002957	dimerization interface [polypeptide binding]; other site
866913002958	multidrug efflux system protein; Provisional; Region: PRK11431
866913002959	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
866913002960	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
866913002961	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
866913002962	Iron-sulfur protein interface; other site
866913002963	proximal quinone binding site [chemical binding]; other site
866913002964	C-subunit interface; other site
866913002965	distal quinone binding site; other site
866913002966	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
866913002967	D-subunit interface [polypeptide binding]; other site
866913002968	Iron-sulfur protein interface; other site
866913002969	proximal quinone binding site [chemical binding]; other site
866913002970	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
866913002971	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
866913002972	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
866913002973	L-aspartate oxidase; Provisional; Region: PRK06175
866913002974	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
866913002975	poxB regulator PoxA; Provisional; Region: PRK09350
866913002976	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866913002977	motif 1; other site
866913002978	dimer interface [polypeptide binding]; other site
866913002979	active site
866913002980	motif 2; other site
866913002981	motif 3; other site
866913002982	inner membrane transporter YjeM; Provisional; Region: PRK15238
866913002983	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
866913002984	putative mechanosensitive channel protein; Provisional; Region: PRK10929
866913002985	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
866913002986	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913002987	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
866913002988	GTPase RsgA; Reviewed; Region: PRK12288
866913002989	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
866913002990	RNA binding site [nucleotide binding]; other site
866913002991	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
866913002992	GTPase/Zn-binding domain interface [polypeptide binding]; other site
866913002993	GTP/Mg2+ binding site [chemical binding]; other site
866913002994	G4 box; other site
866913002995	G5 box; other site
866913002996	G1 box; other site
866913002997	Switch I region; other site
866913002998	G2 box; other site
866913002999	G3 box; other site
866913003000	Switch II region; other site
866913003001	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
866913003002	catalytic site [active]
866913003003	putative active site [active]
866913003004	putative substrate binding site [chemical binding]; other site
866913003005	dimer interface [polypeptide binding]; other site
866913003006	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
866913003007	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913003008	substrate binding pocket [chemical binding]; other site
866913003009	membrane-bound complex binding site; other site
866913003010	hinge residues; other site
866913003011	epoxyqueuosine reductase; Region: TIGR00276
866913003012	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
866913003013	putative carbohydrate kinase; Provisional; Region: PRK10565
866913003014	Uncharacterized conserved protein [Function unknown]; Region: COG0062
866913003015	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
866913003016	putative substrate binding site [chemical binding]; other site
866913003017	putative ATP binding site [chemical binding]; other site
866913003018	ADP-binding protein; Provisional; Region: PRK10646
866913003019	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
866913003020	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866913003021	active site
866913003022	metal binding site [ion binding]; metal-binding site
866913003023	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
866913003024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913003025	ATP binding site [chemical binding]; other site
866913003026	Mg2+ binding site [ion binding]; other site
866913003027	G-X-G motif; other site
866913003028	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
866913003029	ATP binding site [chemical binding]; other site
866913003030	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
866913003031	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
866913003032	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
866913003033	bacterial Hfq-like; Region: Hfq; cd01716
866913003034	hexamer interface [polypeptide binding]; other site
866913003035	Sm1 motif; other site
866913003036	RNA binding site [nucleotide binding]; other site
866913003037	Sm2 motif; other site
866913003038	GTPase HflX; Provisional; Region: PRK11058
866913003039	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
866913003040	HflX GTPase family; Region: HflX; cd01878
866913003041	G1 box; other site
866913003042	GTP/Mg2+ binding site [chemical binding]; other site
866913003043	Switch I region; other site
866913003044	G2 box; other site
866913003045	G3 box; other site
866913003046	Switch II region; other site
866913003047	G4 box; other site
866913003048	G5 box; other site
866913003049	FtsH protease regulator HflK; Provisional; Region: PRK10930
866913003050	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
866913003051	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
866913003052	FtsH protease regulator HflC; Provisional; Region: PRK11029
866913003053	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
866913003054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
866913003055	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
866913003056	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
866913003057	GDP-binding site [chemical binding]; other site
866913003058	ACT binding site; other site
866913003059	IMP binding site; other site
866913003060	transcriptional repressor NsrR; Provisional; Region: PRK11014
866913003061	Predicted transcriptional regulator [Transcription]; Region: COG1959
866913003062	exoribonuclease R; Provisional; Region: PRK11642
866913003063	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
866913003064	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
866913003065	RNB domain; Region: RNB; pfam00773
866913003066	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
866913003067	RNA binding site [nucleotide binding]; other site
866913003068	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
866913003069	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
866913003070	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866913003071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789
866913003072	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
866913003073	Ion channel; Region: Ion_trans_2; pfam07885
866913003074	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
866913003075	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
866913003076	Predicted membrane protein [Function unknown]; Region: COG3766
866913003077	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
866913003078	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
866913003079	Predicted integral membrane protein [Function unknown]; Region: COG5463
866913003080	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
866913003081	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
866913003082	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
866913003083	FAD binding site [chemical binding]; other site
866913003084	substrate binding site [chemical binding]; other site
866913003085	catalytic residues [active]
866913003086	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913003087	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
866913003088	esterase; Provisional; Region: PRK10566
866913003089	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866913003090	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866913003091	transcriptional repressor UlaR; Provisional; Region: PRK13509
866913003092	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866913003093	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913003094	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
866913003095	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
866913003096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
866913003097	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
866913003098	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
866913003099	active site
866913003100	P-loop; other site
866913003101	phosphorylation site [posttranslational modification]
866913003102	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913003103	active site
866913003104	phosphorylation site [posttranslational modification]
866913003105	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
866913003106	active site
866913003107	dimer interface [polypeptide binding]; other site
866913003108	magnesium binding site [ion binding]; other site
866913003109	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
866913003110	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
866913003111	AP (apurinic/apyrimidinic) site pocket; other site
866913003112	DNA interaction; other site
866913003113	Metal-binding active site; metal-binding site
866913003114	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
866913003115	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
866913003116	intersubunit interface [polypeptide binding]; other site
866913003117	active site
866913003118	Zn2+ binding site [ion binding]; other site
866913003119	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913003120	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
866913003121	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
866913003122	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
866913003123	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
866913003124	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
866913003125	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
866913003126	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866913003127	EamA-like transporter family; Region: EamA; pfam00892
866913003128	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
866913003129	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
866913003130	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
866913003131	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
866913003132	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866913003133	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
866913003134	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
866913003135	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
866913003136	Hemerythrin-like domain; Region: Hr-like; cd12108
866913003137	Fe binding site [ion binding]; other site
866913003138	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866913003139	EamA-like transporter family; Region: EamA; pfam00892
866913003140	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
866913003141	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
866913003142	NADP binding site [chemical binding]; other site
866913003143	Predicted transcriptional regulators [Transcription]; Region: COG1733
866913003144	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
866913003145	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
866913003146	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
866913003147	active site
866913003148	metal binding site [ion binding]; metal-binding site
866913003149	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866913003150	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
866913003151	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
866913003152	active site
866913003153	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
866913003154	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
866913003155	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866913003156	Domain of unknown function DUF21; Region: DUF21; pfam01595
866913003157	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866913003158	Transporter associated domain; Region: CorC_HlyC; smart01091
866913003159	methionine sulfoxide reductase A; Provisional; Region: PRK00058
866913003160	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
866913003161	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
866913003162	Surface antigen; Region: Bac_surface_Ag; pfam01103
866913003163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
866913003164	Family of unknown function (DUF490); Region: DUF490; pfam04357
866913003165	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
866913003166	putative active site pocket [active]
866913003167	dimerization interface [polypeptide binding]; other site
866913003168	putative catalytic residue [active]
866913003169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003170	D-galactonate transporter; Region: 2A0114; TIGR00893
866913003171	putative substrate translocation pore; other site
866913003172	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
866913003173	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
866913003174	active site
866913003175	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
866913003176	dimer interface [polypeptide binding]; other site
866913003177	substrate binding site [chemical binding]; other site
866913003178	metal binding sites [ion binding]; metal-binding site
866913003179	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
866913003180	AMP binding site [chemical binding]; other site
866913003181	metal binding site [ion binding]; metal-binding site
866913003182	active site
866913003183	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
866913003184	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866913003185	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866913003186	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866913003187	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866913003188	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866913003189	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866913003190	putative active site [active]
866913003191	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
866913003192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003193	putative substrate translocation pore; other site
866913003194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003195	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
866913003196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003197	putative substrate translocation pore; other site
866913003198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003199	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
866913003200	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
866913003201	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
866913003202	tetrameric interface [polypeptide binding]; other site
866913003203	NAD binding site [chemical binding]; other site
866913003204	catalytic residues [active]
866913003205	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
866913003206	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913003207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913003208	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
866913003209	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866913003210	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866913003211	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866913003212	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
866913003213	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
866913003214	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
866913003215	major facilitator superfamily transporter; Provisional; Region: PRK05122
866913003216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003217	putative substrate translocation pore; other site
866913003218	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913003219	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
866913003220	substrate binding site [chemical binding]; other site
866913003221	ATP binding site [chemical binding]; other site
866913003222	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
866913003223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
866913003224	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
866913003225	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866913003226	PYR/PP interface [polypeptide binding]; other site
866913003227	dimer interface [polypeptide binding]; other site
866913003228	TPP binding site [chemical binding]; other site
866913003229	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866913003230	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
866913003231	TPP-binding site; other site
866913003232	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866913003233	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866913003234	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866913003235	polyol permease family; Region: 2A0118; TIGR00897
866913003236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003237	putative substrate translocation pore; other site
866913003238	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
866913003239	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
866913003240	DNA interaction; other site
866913003241	Metal-binding active site; metal-binding site
866913003242	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
866913003243	hypothetical protein; Provisional; Region: PRK05255
866913003244	peptidase PmbA; Provisional; Region: PRK11040
866913003245	cytochrome b562; Provisional; Region: PRK15058
866913003246	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
866913003247	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
866913003248	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
866913003249	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
866913003250	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
866913003251	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
866913003252	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
866913003253	active site
866913003254	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
866913003255	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
866913003256	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866913003257	HTH domain; Region: HTH_11; pfam08279
866913003258	Mga helix-turn-helix domain; Region: Mga; pfam05043
866913003259	PRD domain; Region: PRD; pfam00874
866913003260	PRD domain; Region: PRD; pfam00874
866913003261	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866913003262	active site
866913003263	P-loop; other site
866913003264	phosphorylation site [posttranslational modification]
866913003265	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913003266	active site
866913003267	phosphorylation site [posttranslational modification]
866913003268	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
866913003269	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
866913003270	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
866913003271	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913003272	FeS/SAM binding site; other site
866913003273	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
866913003274	ATP cone domain; Region: ATP-cone; pfam03477
866913003275	Class III ribonucleotide reductase; Region: RNR_III; cd01675
866913003276	effector binding site; other site
866913003277	active site
866913003278	Zn binding site [ion binding]; other site
866913003279	glycine loop; other site
866913003280	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
866913003281	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
866913003282	Ca binding site [ion binding]; other site
866913003283	active site
866913003284	catalytic site [active]
866913003285	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
866913003286	trehalose repressor; Provisional; Region: treR; PRK09492
866913003287	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913003288	DNA binding site [nucleotide binding]
866913003289	domain linker motif; other site
866913003290	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
866913003291	dimerization interface [polypeptide binding]; other site
866913003292	ligand binding site [chemical binding]; other site
866913003293	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
866913003294	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
866913003295	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866913003296	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
866913003297	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
866913003298	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866913003299	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
866913003300	Transposase; Region: HTH_Tnp_1; cl17663
866913003301	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
866913003302	homotrimer interaction site [polypeptide binding]; other site
866913003303	putative active site [active]
866913003304	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
866913003305	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
866913003306	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
866913003307	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
866913003308	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866913003309	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866913003310	Arginine repressor [Transcription]; Region: ArgR; COG1438
866913003311	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
866913003312	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
866913003313	Predicted membrane protein [Function unknown]; Region: COG1288
866913003314	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
866913003315	ornithine carbamoyltransferase; Validated; Region: PRK02102
866913003316	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866913003317	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866913003318	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
866913003319	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
866913003320	putative substrate binding site [chemical binding]; other site
866913003321	nucleotide binding site [chemical binding]; other site
866913003322	nucleotide binding site [chemical binding]; other site
866913003323	homodimer interface [polypeptide binding]; other site
866913003324	arginine deiminase; Provisional; Region: PRK01388
866913003325	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
866913003326	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
866913003327	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866913003328	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866913003329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
866913003330	RNase E inhibitor protein; Provisional; Region: PRK11191
866913003331	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
866913003332	active site
866913003333	dinuclear metal binding site [ion binding]; other site
866913003334	dimerization interface [polypeptide binding]; other site
866913003335	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
866913003336	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866913003337	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913003338	Coenzyme A binding pocket [chemical binding]; other site
866913003339	Predicted membrane protein [Function unknown]; Region: COG4269
866913003340	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
866913003341	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
866913003342	HIGH motif; other site
866913003343	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
866913003344	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
866913003345	active site
866913003346	KMSKS motif; other site
866913003347	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
866913003348	tRNA binding surface [nucleotide binding]; other site
866913003349	anticodon binding site; other site
866913003350	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
866913003351	DNA polymerase III subunit chi; Validated; Region: PRK05728
866913003352	multifunctional aminopeptidase A; Provisional; Region: PRK00913
866913003353	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
866913003354	interface (dimer of trimers) [polypeptide binding]; other site
866913003355	Substrate-binding/catalytic site; other site
866913003356	Zn-binding sites [ion binding]; other site
866913003357	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
866913003358	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
866913003359	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
866913003360	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
866913003361	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
866913003362	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913003363	DNA binding site [nucleotide binding]
866913003364	domain linker motif; other site
866913003365	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
866913003366	putative dimerization interface [polypeptide binding]; other site
866913003367	putative ligand binding site [chemical binding]; other site
866913003368	gluconate transporter; Region: gntP; TIGR00791
866913003369	fructuronate transporter; Provisional; Region: PRK10034; cl15264
866913003370	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
866913003371	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
866913003372	NADP binding site [chemical binding]; other site
866913003373	homodimer interface [polypeptide binding]; other site
866913003374	active site
866913003375	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
866913003376	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
866913003377	putative NAD(P) binding site [chemical binding]; other site
866913003378	catalytic Zn binding site [ion binding]; other site
866913003379	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
866913003380	ATP-binding site [chemical binding]; other site
866913003381	Gluconate-6-phosphate binding site [chemical binding]; other site
866913003382	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
866913003383	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
866913003384	putative NAD(P) binding site [chemical binding]; other site
866913003385	putative substrate binding site [chemical binding]; other site
866913003386	catalytic Zn binding site [ion binding]; other site
866913003387	structural Zn binding site [ion binding]; other site
866913003388	dimer interface [polypeptide binding]; other site
866913003389	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
866913003390	Uncharacterized conserved protein [Function unknown]; Region: COG4127
866913003391	Restriction endonuclease; Region: Mrr_cat; pfam04471
866913003392	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
866913003393	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
866913003394	TIGR02687 family protein; Region: TIGR02687
866913003395	PglZ domain; Region: PglZ; pfam08665
866913003396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913003397	AAA domain; Region: AAA_21; pfam13304
866913003398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913003399	Walker A/P-loop; other site
866913003400	Walker A/P-loop; other site
866913003401	ATP binding site [chemical binding]; other site
866913003402	ATP binding site [chemical binding]; other site
866913003403	Q-loop/lid; other site
866913003404	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
866913003405	Methyltransferase domain; Region: Methyltransf_26; pfam13659
866913003406	TIGR02680 family protein; Region: TIGR02680
866913003407	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
866913003408	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
866913003409	hypothetical protein; Provisional; Region: PRK12378
866913003410	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866913003411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913003412	S-adenosylmethionine binding site [chemical binding]; other site
866913003413	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866913003414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913003415	S-adenosylmethionine binding site [chemical binding]; other site
866913003416	hypothetical protein; Provisional; Region: PRK13687
866913003417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332
866913003418	Protein of unknown function DUF91; Region: DUF91; cl00709
866913003419	Uncharacterized conserved protein [Function unknown]; Region: COG3439
866913003420	Dienelactone hydrolase family; Region: DLH; pfam01738
866913003421	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
866913003422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913003423	DNA-binding site [nucleotide binding]; DNA binding site
866913003424	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
866913003425	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
866913003426	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
866913003427	active site
866913003428	HIGH motif; other site
866913003429	dimer interface [polypeptide binding]; other site
866913003430	KMSKS motif; other site
866913003431	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
866913003432	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
866913003433	aspartate racemase; Region: asp_race; TIGR00035
866913003434	cell density-dependent motility repressor; Provisional; Region: PRK10082
866913003435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913003436	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866913003437	dimerization interface [polypeptide binding]; other site
866913003438	isoaspartyl dipeptidase; Provisional; Region: PRK10657
866913003439	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866913003440	active site
866913003441	hypothetical protein; Provisional; Region: PRK10519
866913003442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
866913003443	Nucleoside recognition; Region: Gate; pfam07670
866913003444	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
866913003445	Predicted membrane protein [Function unknown]; Region: COG2733
866913003446	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
866913003447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003448	putative substrate translocation pore; other site
866913003449	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
866913003450	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
866913003451	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
866913003452	NAD(P) binding site [chemical binding]; other site
866913003453	catalytic residues [active]
866913003454	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
866913003455	endoribonuclease SymE; Provisional; Region: PRK13605
866913003456	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
866913003457	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
866913003458	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
866913003459	HsdM N-terminal domain; Region: HsdM_N; pfam12161
866913003460	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
866913003461	Methyltransferase domain; Region: Methyltransf_26; pfam13659
866913003462	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
866913003463	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
866913003464	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
866913003465	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913003466	ATP binding site [chemical binding]; other site
866913003467	putative Mg++ binding site [ion binding]; other site
866913003468	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
866913003469	Mrr N-terminal domain; Region: Mrr_N; pfam14338
866913003470	Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like...; Region: CH; cl00030
866913003471	Restriction endonuclease; Region: Mrr_cat; pfam04471
866913003472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
866913003473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
866913003474	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
866913003475	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
866913003476	P-loop, Walker A motif; other site
866913003477	Base recognition motif; other site
866913003478	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
866913003479	Uncharacterized small protein [Function unknown]; Region: COG2879
866913003480	carbon starvation protein A; Provisional; Region: PRK15015
866913003481	Carbon starvation protein CstA; Region: CstA; pfam02554
866913003482	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
866913003483	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
866913003484	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
866913003485	dimer interface [polypeptide binding]; other site
866913003486	ligand binding site [chemical binding]; other site
866913003487	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913003488	dimerization interface [polypeptide binding]; other site
866913003489	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913003490	dimer interface [polypeptide binding]; other site
866913003491	putative CheW interface [polypeptide binding]; other site
866913003492	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
866913003493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913003494	Walker A motif; other site
866913003495	ATP binding site [chemical binding]; other site
866913003496	Walker B motif; other site
866913003497	arginine finger; other site
866913003498	Transcriptional antiterminator [Transcription]; Region: COG3933
866913003499	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866913003500	active pocket/dimerization site; other site
866913003501	active site
866913003502	phosphorylation site [posttranslational modification]
866913003503	PRD domain; Region: PRD; pfam00874
866913003504	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866913003505	active pocket/dimerization site; other site
866913003506	active site
866913003507	phosphorylation site [posttranslational modification]
866913003508	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
866913003509	active site
866913003510	phosphorylation site [posttranslational modification]
866913003511	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
866913003512	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
866913003513	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
866913003514	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
866913003515	dimer interface [polypeptide binding]; other site
866913003516	active site
866913003517	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866913003518	dimer interface [polypeptide binding]; other site
866913003519	active site
866913003520	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
866913003521	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
866913003522	putative active site [active]
866913003523	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
866913003524	phosphoglycerol transferase I; Provisional; Region: PRK03776
866913003525	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
866913003526	hypothetical protein; Provisional; Region: PRK11667
866913003527	DNA replication protein DnaC; Validated; Region: PRK07952
866913003528	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913003529	Walker A motif; other site
866913003530	ATP binding site [chemical binding]; other site
866913003531	Walker B motif; other site
866913003532	primosomal protein DnaI; Provisional; Region: PRK02854
866913003533	hypothetical protein; Provisional; Region: PRK09917
866913003534	Uncharacterized conserved protein [Function unknown]; Region: COG2966
866913003535	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
866913003536	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866913003537	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913003538	DNA binding residues [nucleotide binding]
866913003539	dimerization interface [polypeptide binding]; other site
866913003540	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
866913003541	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913003542	DNA binding residues [nucleotide binding]
866913003543	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
866913003544	putative deacylase active site [active]
866913003545	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
866913003546	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
866913003547	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
866913003548	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866913003549	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913003550	metal binding site [ion binding]; metal-binding site
866913003551	active site
866913003552	I-site; other site
866913003553	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
866913003554	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
866913003555	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
866913003556	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913003557	S-adenosylmethionine binding site [chemical binding]; other site
866913003558	DNA polymerase III subunit psi; Validated; Region: PRK06856
866913003559	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
866913003560	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913003561	Coenzyme A binding pocket [chemical binding]; other site
866913003562	dUMP phosphatase; Provisional; Region: PRK09449
866913003563	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913003564	motif II; other site
866913003565	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
866913003566	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
866913003567	G1 box; other site
866913003568	putative GEF interaction site [polypeptide binding]; other site
866913003569	GTP/Mg2+ binding site [chemical binding]; other site
866913003570	Switch I region; other site
866913003571	G2 box; other site
866913003572	G3 box; other site
866913003573	Switch II region; other site
866913003574	G4 box; other site
866913003575	G5 box; other site
866913003576	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
866913003577	periplasmic protein; Provisional; Region: PRK10568
866913003578	BON domain; Region: BON; pfam04972
866913003579	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
866913003580	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
866913003581	active site
866913003582	nucleophile elbow; other site
866913003583	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
866913003584	active site
866913003585	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
866913003586	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913003587	FeS/SAM binding site; other site
866913003588	hypothetical protein; Provisional; Region: PRK10977
866913003589	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
866913003590	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
866913003591	intersubunit interface [polypeptide binding]; other site
866913003592	active site
866913003593	catalytic residue [active]
866913003594	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
866913003595	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
866913003596	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
866913003597	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
866913003598	phosphopentomutase; Provisional; Region: PRK05362
866913003599	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
866913003600	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
866913003601	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
866913003602	hypothetical protein; Provisional; Region: PRK15301
866913003603	putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304
866913003604	PapC N-terminal domain; Region: PapC_N; pfam13954
866913003605	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913003606	PapC C-terminal domain; Region: PapC_C; pfam13953
866913003607	putative fimbrial chaperone protein; Provisional; Region: PRK09918
866913003608	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913003609	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913003610	hypothetical protein; Provisional; Region: PRK15302
866913003611	hypothetical protein; Provisional; Region: PRK15303
866913003612	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
866913003613	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866913003614	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
866913003615	hypothetical protein; Provisional; Region: PRK11246
866913003616	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
866913003617	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913003618	motif II; other site
866913003619	DNA repair protein RadA; Region: sms; TIGR00416
866913003620	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
866913003621	Walker A motif/ATP binding site; other site
866913003622	ATP binding site [chemical binding]; other site
866913003623	Walker B motif; other site
866913003624	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
866913003625	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913003626	non-specific DNA binding site [nucleotide binding]; other site
866913003627	salt bridge; other site
866913003628	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
866913003629	sequence-specific DNA binding site [nucleotide binding]; other site
866913003630	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
866913003631	active site
866913003632	(T/H)XGH motif; other site
866913003633	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
866913003634	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
866913003635	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913003636	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913003637	ABC transporter; Region: ABC_tran_2; pfam12848
866913003638	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913003639	lytic murein transglycosylase; Provisional; Region: PRK11619
866913003640	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913003641	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913003642	catalytic residue [active]
866913003643	Trp operon repressor; Provisional; Region: PRK01381
866913003644	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
866913003645	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866913003646	catalytic core [active]
866913003647	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
866913003648	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913003649	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
866913003650	hypothetical protein; Provisional; Region: PRK10756
866913003651	CreA protein; Region: CreA; pfam05981
866913003652	DNA-binding response regulator CreB; Provisional; Region: PRK11083
866913003653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913003654	active site
866913003655	phosphorylation site [posttranslational modification]
866913003656	intermolecular recognition site; other site
866913003657	dimerization interface [polypeptide binding]; other site
866913003658	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913003659	DNA binding site [nucleotide binding]
866913003660	sensory histidine kinase CreC; Provisional; Region: PRK11100
866913003661	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
866913003662	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913003663	dimer interface [polypeptide binding]; other site
866913003664	phosphorylation site [posttranslational modification]
866913003665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913003666	ATP binding site [chemical binding]; other site
866913003667	Mg2+ binding site [ion binding]; other site
866913003668	G-X-G motif; other site
866913003669	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
866913003670	putative major fimbrial protein SthE; Provisional; Region: PRK15292
866913003671	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
866913003672	putative fimbrial protein SthD; Provisional; Region: PRK15293
866913003673	putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294
866913003674	PapC N-terminal domain; Region: PapC_N; pfam13954
866913003675	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913003676	PapC C-terminal domain; Region: PapC_C; pfam13953
866913003677	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
866913003678	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913003679	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913003680	putative fimbrial protein SthA; Provisional; Region: PRK15296
866913003681	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
866913003682	Helix-turn-helix domain; Region: HTH_36; pfam13730
866913003683	two-component response regulator; Provisional; Region: PRK11173
866913003684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913003685	active site
866913003686	phosphorylation site [posttranslational modification]
866913003687	intermolecular recognition site; other site
866913003688	dimerization interface [polypeptide binding]; other site
866913003689	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913003690	DNA binding site [nucleotide binding]
866913003691	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
866913003692	putative RNA methyltransferase; Provisional; Region: PRK10433
866913003693	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
866913003694	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
866913003695	putative catalytic residues [active]
866913003696	putative nucleotide binding site [chemical binding]; other site
866913003697	putative aspartate binding site [chemical binding]; other site
866913003698	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
866913003699	dimer interface [polypeptide binding]; other site
866913003700	putative threonine allosteric regulatory site; other site
866913003701	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
866913003702	putative threonine allosteric regulatory site; other site
866913003703	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
866913003704	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
866913003705	homoserine kinase; Provisional; Region: PRK01212
866913003706	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866913003707	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
866913003708	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
866913003709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913003710	catalytic residue [active]
866913003711	hypothetical protein; Validated; Region: PRK02101
866913003712	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
866913003713	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
866913003714	transaldolase-like protein; Provisional; Region: PTZ00411
866913003715	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
866913003716	active site
866913003717	dimer interface [polypeptide binding]; other site
866913003718	catalytic residue [active]
866913003719	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
866913003720	MPT binding site; other site
866913003721	trimer interface [polypeptide binding]; other site
866913003722	hypothetical protein; Provisional; Region: PRK10659
866913003723	hypothetical protein; Provisional; Region: PRK10236
866913003724	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
866913003725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
866913003726	Protein of unknown function (DUF2541); Region: DUF2541; pfam10807
866913003727	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
866913003728	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866913003729	nucleotide binding site [chemical binding]; other site
866913003730	chaperone protein DnaJ; Provisional; Region: PRK10767
866913003731	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866913003732	HSP70 interaction site [polypeptide binding]; other site
866913003733	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
866913003734	substrate binding site [polypeptide binding]; other site
866913003735	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
866913003736	Zn binding sites [ion binding]; other site
866913003737	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
866913003738	dimer interface [polypeptide binding]; other site
866913003739	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913003740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913003741	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
866913003742	substrate binding pocket [chemical binding]; other site
866913003743	dimerization interface [polypeptide binding]; other site
866913003744	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
866913003745	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
866913003746	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
866913003747	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
866913003748	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
866913003749	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
866913003750	active site
866913003751	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
866913003752	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
866913003753	aromatic chitin/cellulose binding site residues [chemical binding]; other site
866913003754	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
866913003755	Helix-turn-helix domain; Region: HTH_36; pfam13730
866913003756	fimbrial protein BcfA; Provisional; Region: PRK15187
866913003757	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
866913003758	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913003759	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913003760	outer membrane usher protein; Provisional; Region: PRK15193
866913003761	PapC N-terminal domain; Region: PapC_N; pfam13954
866913003762	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913003763	PapC C-terminal domain; Region: PapC_C; pfam13953
866913003764	fimbrial protein BcfD; Provisional; Region: PRK15189
866913003765	fimbrial protein BcfE; Provisional; Region: PRK15190
866913003766	fimbrial protein BcfF; Provisional; Region: PRK15191
866913003767	fimbrial chaperone BcfG; Provisional; Region: PRK15192
866913003768	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913003769	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913003770	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
866913003771	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
866913003772	catalytic residues [active]
866913003773	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
866913003774	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913003775	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913003776	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913003777	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
866913003778	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
866913003779	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
866913003780	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
866913003781	active site
866913003782	metal binding site [ion binding]; metal-binding site
866913003783	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866913003784	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
866913003785	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
866913003786	Sulfatase; Region: Sulfatase; pfam00884
866913003787	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
866913003788	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913003789	FeS/SAM binding site; other site
866913003790	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
866913003791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
866913003792	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
866913003793	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
866913003794	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
866913003795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913003796	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
866913003797	putative dimerization interface [polypeptide binding]; other site
866913003798	putative alpha-glucosidase; Provisional; Region: PRK10658
866913003799	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
866913003800	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
866913003801	putative active site [active]
866913003802	putative catalytic site [active]
866913003803	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
866913003804	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
866913003805	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
866913003806	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
866913003807	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
866913003808	active site
866913003809	Riboflavin kinase; Region: Flavokinase; smart00904
866913003810	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
866913003811	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866913003812	active site
866913003813	HIGH motif; other site
866913003814	nucleotide binding site [chemical binding]; other site
866913003815	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
866913003816	active site
866913003817	KMSKS motif; other site
866913003818	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
866913003819	tRNA binding surface [nucleotide binding]; other site
866913003820	anticodon binding site; other site
866913003821	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
866913003822	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
866913003823	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
866913003824	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866913003825	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
866913003826	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
866913003827	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
866913003828	active site
866913003829	tetramer interface [polypeptide binding]; other site
866913003830	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
866913003831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913003832	active site
866913003833	phosphorylation site [posttranslational modification]
866913003834	intermolecular recognition site; other site
866913003835	dimerization interface [polypeptide binding]; other site
866913003836	Transcriptional regulator; Region: CitT; pfam12431
866913003837	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
866913003838	PAS domain; Region: PAS; smart00091
866913003839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913003840	ATP binding site [chemical binding]; other site
866913003841	Mg2+ binding site [ion binding]; other site
866913003842	G-X-G motif; other site
866913003843	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
866913003844	oxaloacetate decarboxylase; Provisional; Region: PRK14040
866913003845	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
866913003846	active site
866913003847	catalytic residues [active]
866913003848	metal binding site [ion binding]; metal-binding site
866913003849	homodimer binding site [polypeptide binding]; other site
866913003850	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866913003851	carboxyltransferase (CT) interaction site; other site
866913003852	biotinylation site [posttranslational modification]; other site
866913003853	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
866913003854	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
866913003855	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
866913003856	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
866913003857	putative active site [active]
866913003858	(T/H)XGH motif; other site
866913003859	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
866913003860	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
866913003861	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
866913003862	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
866913003863	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
866913003864	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
866913003865	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
866913003866	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
866913003867	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
866913003868	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
866913003869	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
866913003870	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
866913003871	catalytic site [active]
866913003872	subunit interface [polypeptide binding]; other site
866913003873	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
866913003874	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866913003875	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
866913003876	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
866913003877	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866913003878	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866913003879	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
866913003880	IMP binding site; other site
866913003881	dimer interface [polypeptide binding]; other site
866913003882	interdomain contacts; other site
866913003883	partial ornithine binding site; other site
866913003884	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
866913003885	carnitine operon protein CaiE; Provisional; Region: PRK13627
866913003886	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
866913003887	putative trimer interface [polypeptide binding]; other site
866913003888	putative metal binding site [ion binding]; other site
866913003889	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
866913003890	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866913003891	substrate binding site [chemical binding]; other site
866913003892	oxyanion hole (OAH) forming residues; other site
866913003893	trimer interface [polypeptide binding]; other site
866913003894	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
866913003895	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
866913003896	acyl-activating enzyme (AAE) consensus motif; other site
866913003897	putative AMP binding site [chemical binding]; other site
866913003898	putative active site [active]
866913003899	putative CoA binding site [chemical binding]; other site
866913003900	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
866913003901	CoA-transferase family III; Region: CoA_transf_3; pfam02515
866913003902	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
866913003903	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
866913003904	active site
866913003905	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
866913003906	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
866913003907	Ligand binding site [chemical binding]; other site
866913003908	Electron transfer flavoprotein domain; Region: ETF; pfam01012
866913003909	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
866913003910	Electron transfer flavoprotein domain; Region: ETF; smart00893
866913003911	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
866913003912	putative oxidoreductase FixC; Provisional; Region: PRK10157
866913003913	ferredoxin-like protein FixX; Provisional; Region: PRK15449
866913003914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913003915	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
866913003916	putative substrate translocation pore; other site
866913003917	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
866913003918	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913003919	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
866913003920	Sulfatase; Region: Sulfatase; cl17466
866913003921	Sulfatase; Region: Sulfatase; cl17466
866913003922	Sulfatase; Region: Sulfatase; cl17466
866913003923	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
866913003924	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
866913003925	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
866913003926	TrkA-N domain; Region: TrkA_N; pfam02254
866913003927	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
866913003928	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
866913003929	folate binding site [chemical binding]; other site
866913003930	NADP+ binding site [chemical binding]; other site
866913003931	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
866913003932	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
866913003933	active site
866913003934	metal binding site [ion binding]; metal-binding site
866913003935	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
866913003936	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
866913003937	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
866913003938	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
866913003939	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
866913003940	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
866913003941	SurA N-terminal domain; Region: SurA_N; pfam09312
866913003942	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
866913003943	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
866913003944	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
866913003945	OstA-like protein; Region: OstA; pfam03968
866913003946	Organic solvent tolerance protein; Region: OstA_C; pfam04453
866913003947	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
866913003948	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
866913003949	putative metal binding site [ion binding]; other site
866913003950	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866913003951	HSP70 interaction site [polypeptide binding]; other site
866913003952	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866913003953	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866913003954	active site
866913003955	ATP-dependent helicase HepA; Validated; Region: PRK04914
866913003956	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913003957	ATP binding site [chemical binding]; other site
866913003958	putative Mg++ binding site [ion binding]; other site
866913003959	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913003960	nucleotide binding region [chemical binding]; other site
866913003961	ATP-binding site [chemical binding]; other site
866913003962	DNA polymerase II; Reviewed; Region: PRK05762
866913003963	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
866913003964	active site
866913003965	catalytic site [active]
866913003966	substrate binding site [chemical binding]; other site
866913003967	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
866913003968	active site
866913003969	metal-binding site
866913003970	Uncharacterized conserved protein [Function unknown]; Region: COG1434
866913003971	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866913003972	putative active site [active]
866913003973	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
866913003974	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
866913003975	intersubunit interface [polypeptide binding]; other site
866913003976	active site
866913003977	Zn2+ binding site [ion binding]; other site
866913003978	L-arabinose isomerase; Provisional; Region: PRK02929
866913003979	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
866913003980	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
866913003981	trimer interface [polypeptide binding]; other site
866913003982	putative substrate binding site [chemical binding]; other site
866913003983	putative metal binding site [ion binding]; other site
866913003984	ribulokinase; Provisional; Region: PRK04123
866913003985	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
866913003986	N- and C-terminal domain interface [polypeptide binding]; other site
866913003987	active site
866913003988	MgATP binding site [chemical binding]; other site
866913003989	catalytic site [active]
866913003990	metal binding site [ion binding]; metal-binding site
866913003991	carbohydrate binding site [chemical binding]; other site
866913003992	homodimer interface [polypeptide binding]; other site
866913003993	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
866913003994	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
866913003995	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913003996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913003997	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866913003998	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866913003999	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
866913004000	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
866913004001	Walker A/P-loop; other site
866913004002	ATP binding site [chemical binding]; other site
866913004003	Q-loop/lid; other site
866913004004	ABC transporter signature motif; other site
866913004005	Walker B; other site
866913004006	D-loop; other site
866913004007	H-loop/switch region; other site
866913004008	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
866913004009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913004010	dimer interface [polypeptide binding]; other site
866913004011	conserved gate region; other site
866913004012	putative PBP binding loops; other site
866913004013	ABC-ATPase subunit interface; other site
866913004014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913004015	dimer interface [polypeptide binding]; other site
866913004016	conserved gate region; other site
866913004017	putative PBP binding loops; other site
866913004018	ABC-ATPase subunit interface; other site
866913004019	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
866913004020	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
866913004021	transcriptional regulator SgrR; Provisional; Region: PRK13626
866913004022	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
866913004023	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
866913004024	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
866913004025	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
866913004026	substrate binding site [chemical binding]; other site
866913004027	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
866913004028	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
866913004029	substrate binding site [chemical binding]; other site
866913004030	ligand binding site [chemical binding]; other site
866913004031	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
866913004032	tartrate dehydrogenase; Region: TTC; TIGR02089
866913004033	2-isopropylmalate synthase; Validated; Region: PRK00915
866913004034	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
866913004035	active site
866913004036	catalytic residues [active]
866913004037	metal binding site [ion binding]; metal-binding site
866913004038	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
866913004039	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
866913004040	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913004041	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
866913004042	putative substrate binding pocket [chemical binding]; other site
866913004043	putative dimerization interface [polypeptide binding]; other site
866913004044	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
866913004045	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866913004046	PYR/PP interface [polypeptide binding]; other site
866913004047	dimer interface [polypeptide binding]; other site
866913004048	TPP binding site [chemical binding]; other site
866913004049	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866913004050	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
866913004051	TPP-binding site [chemical binding]; other site
866913004052	dimer interface [polypeptide binding]; other site
866913004053	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
866913004054	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
866913004055	putative valine binding site [chemical binding]; other site
866913004056	dimer interface [polypeptide binding]; other site
866913004057	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
866913004058	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
866913004059	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913004060	DNA binding site [nucleotide binding]
866913004061	domain linker motif; other site
866913004062	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
866913004063	dimerization interface [polypeptide binding]; other site
866913004064	ligand binding site [chemical binding]; other site
866913004065	mraZ protein; Region: TIGR00242
866913004066	MraZ protein; Region: MraZ; pfam02381
866913004067	MraZ protein; Region: MraZ; pfam02381
866913004068	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
866913004069	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
866913004070	cell division protein FtsL; Provisional; Region: PRK10772
866913004071	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
866913004072	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866913004073	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866913004074	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
866913004075	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866913004076	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866913004077	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866913004078	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
866913004079	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866913004080	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866913004081	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866913004082	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
866913004083	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
866913004084	Mg++ binding site [ion binding]; other site
866913004085	putative catalytic motif [active]
866913004086	putative substrate binding site [chemical binding]; other site
866913004087	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
866913004088	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866913004089	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866913004090	cell division protein FtsW; Provisional; Region: PRK10774
866913004091	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
866913004092	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
866913004093	active site
866913004094	homodimer interface [polypeptide binding]; other site
866913004095	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
866913004096	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866913004097	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866913004098	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866913004099	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
866913004100	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
866913004101	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
866913004102	cell division protein FtsQ; Provisional; Region: PRK10775
866913004103	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
866913004104	Cell division protein FtsQ; Region: FtsQ; pfam03799
866913004105	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
866913004106	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913004107	Cell division protein FtsA; Region: FtsA; pfam14450
866913004108	cell division protein FtsZ; Validated; Region: PRK09330
866913004109	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
866913004110	nucleotide binding site [chemical binding]; other site
866913004111	SulA interaction site; other site
866913004112	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
866913004113	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
866913004114	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
866913004115	SecA regulator SecM; Provisional; Region: PRK02943
866913004116	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
866913004117	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
866913004118	SEC-C motif; Region: SEC-C; pfam02810
866913004119	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
866913004120	active site
866913004121	8-oxo-dGMP binding site [chemical binding]; other site
866913004122	nudix motif; other site
866913004123	metal binding site [ion binding]; metal-binding site
866913004124	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
866913004125	DNA gyrase inhibitor; Reviewed; Region: PRK00418
866913004126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
866913004127	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
866913004128	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
866913004129	CoA-binding site [chemical binding]; other site
866913004130	ATP-binding [chemical binding]; other site
866913004131	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
866913004132	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866913004133	active site
866913004134	type IV pilin biogenesis protein; Provisional; Region: PRK10573
866913004135	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
866913004136	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
866913004137	hypothetical protein; Provisional; Region: PRK10436
866913004138	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
866913004139	Walker A motif; other site
866913004140	ATP binding site [chemical binding]; other site
866913004141	Walker B motif; other site
866913004142	putative major pilin subunit; Provisional; Region: PRK10574
866913004143	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
866913004144	Pilin (bacterial filament); Region: Pilin; pfam00114
866913004145	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
866913004146	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
866913004147	dimerization interface [polypeptide binding]; other site
866913004148	active site
866913004149	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
866913004150	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
866913004151	amidase catalytic site [active]
866913004152	Zn binding residues [ion binding]; other site
866913004153	substrate binding site [chemical binding]; other site
866913004154	regulatory protein AmpE; Provisional; Region: PRK10987
866913004155	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
866913004156	active site
866913004157	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
866913004158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913004159	putative substrate translocation pore; other site
866913004160	aromatic amino acid transporter; Provisional; Region: PRK10238
866913004161	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
866913004162	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913004163	DNA-binding site [nucleotide binding]; DNA binding site
866913004164	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
866913004165	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
866913004166	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
866913004167	dimer interface [polypeptide binding]; other site
866913004168	TPP-binding site [chemical binding]; other site
866913004169	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
866913004170	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866913004171	E3 interaction surface; other site
866913004172	lipoyl attachment site [posttranslational modification]; other site
866913004173	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866913004174	E3 interaction surface; other site
866913004175	lipoyl attachment site [posttranslational modification]; other site
866913004176	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866913004177	E3 interaction surface; other site
866913004178	lipoyl attachment site [posttranslational modification]; other site
866913004179	e3 binding domain; Region: E3_binding; pfam02817
866913004180	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866913004181	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
866913004182	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866913004183	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913004184	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866913004185	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
866913004186	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
866913004187	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
866913004188	substrate binding site [chemical binding]; other site
866913004189	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
866913004190	substrate binding site [chemical binding]; other site
866913004191	ligand binding site [chemical binding]; other site
866913004192	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
866913004193	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
866913004194	hypothetical protein; Provisional; Region: PRK05248
866913004195	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
866913004196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
866913004197	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
866913004198	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
866913004199	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913004200	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866913004201	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913004202	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
866913004203	spermidine synthase; Provisional; Region: PRK00811
866913004204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913004205	S-adenosylmethionine binding site [chemical binding]; other site
866913004206	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
866913004207	multicopper oxidase; Provisional; Region: PRK10965
866913004208	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
866913004209	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
866913004210	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
866913004211	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
866913004212	Trp docking motif [polypeptide binding]; other site
866913004213	putative active site [active]
866913004214	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
866913004215	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913004216	active site
866913004217	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
866913004218	active site clefts [active]
866913004219	zinc binding site [ion binding]; other site
866913004220	dimer interface [polypeptide binding]; other site
866913004221	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866913004222	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866913004223	Walker A/P-loop; other site
866913004224	ATP binding site [chemical binding]; other site
866913004225	Q-loop/lid; other site
866913004226	ABC transporter signature motif; other site
866913004227	Walker B; other site
866913004228	D-loop; other site
866913004229	H-loop/switch region; other site
866913004230	inner membrane transport permease; Provisional; Region: PRK15066
866913004231	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866913004232	putative fimbrial protein StiH; Provisional; Region: PRK15297
866913004233	fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298
866913004234	PapC N-terminal domain; Region: PapC_N; pfam13954
866913004235	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913004236	PapC C-terminal domain; Region: PapC_C; pfam13953
866913004237	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
866913004238	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913004239	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913004240	fimbrial protein StiA; Provisional; Region: PRK15300
866913004241	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866913004242	active pocket/dimerization site; other site
866913004243	active site
866913004244	phosphorylation site [posttranslational modification]
866913004245	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
866913004246	putative active site [active]
866913004247	putative metal binding site [ion binding]; other site
866913004248	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
866913004249	tetramerization interface [polypeptide binding]; other site
866913004250	active site
866913004251	Pantoate-beta-alanine ligase; Region: PanC; cd00560
866913004252	pantoate--beta-alanine ligase; Region: panC; TIGR00018
866913004253	active site
866913004254	ATP-binding site [chemical binding]; other site
866913004255	pantoate-binding site; other site
866913004256	HXXH motif; other site
866913004257	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
866913004258	oligomerization interface [polypeptide binding]; other site
866913004259	active site
866913004260	metal binding site [ion binding]; metal-binding site
866913004261	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
866913004262	catalytic center binding site [active]
866913004263	ATP binding site [chemical binding]; other site
866913004264	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
866913004265	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
866913004266	active site
866913004267	NTP binding site [chemical binding]; other site
866913004268	metal binding triad [ion binding]; metal-binding site
866913004269	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
866913004270	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
866913004271	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
866913004272	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
866913004273	active site
866913004274	nucleotide binding site [chemical binding]; other site
866913004275	HIGH motif; other site
866913004276	KMSKS motif; other site
866913004277	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
866913004278	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
866913004279	2'-5' RNA ligase; Provisional; Region: PRK15124
866913004280	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
866913004281	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
866913004282	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
866913004283	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913004284	ATP binding site [chemical binding]; other site
866913004285	putative Mg++ binding site [ion binding]; other site
866913004286	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913004287	nucleotide binding region [chemical binding]; other site
866913004288	ATP-binding site [chemical binding]; other site
866913004289	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
866913004290	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
866913004291	Transglycosylase; Region: Transgly; pfam00912
866913004292	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866913004293	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
866913004294	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913004295	N-terminal plug; other site
866913004296	ligand-binding site [chemical binding]; other site
866913004297	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
866913004298	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866913004299	Walker A/P-loop; other site
866913004300	ATP binding site [chemical binding]; other site
866913004301	Q-loop/lid; other site
866913004302	ABC transporter signature motif; other site
866913004303	Walker B; other site
866913004304	D-loop; other site
866913004305	H-loop/switch region; other site
866913004306	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
866913004307	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
866913004308	siderophore binding site; other site
866913004309	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866913004310	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913004311	ABC-ATPase subunit  interface; other site
866913004312	dimer interface [polypeptide binding]; other site
866913004313	putative PBP binding regions; other site
866913004314	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913004315	ABC-ATPase subunit  interface; other site
866913004316	dimer interface [polypeptide binding]; other site
866913004317	putative PBP binding regions; other site
866913004318	putative fimbrial subunit StfA; Provisional; Region: PRK15283
866913004319	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
866913004320	PapC N-terminal domain; Region: PapC_N; pfam13954
866913004321	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913004322	PapC C-terminal domain; Region: PapC_C; pfam13953
866913004323	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
866913004324	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913004325	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913004326	putative minor fimbrial subunit StfE; Provisional; Region: PRK15286
866913004327	putative minor fimbrial subunit StfF; Provisional; Region: PRK15287
866913004328	putative minor fimbrial subunit StfG; Provisional; Region: PRK15288
866913004329	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
866913004330	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
866913004331	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866913004332	inhibitor-cofactor binding pocket; inhibition site
866913004333	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913004334	catalytic residue [active]
866913004335	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
866913004336	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
866913004337	Cl- selectivity filter; other site
866913004338	Cl- binding residues [ion binding]; other site
866913004339	pore gating glutamate residue; other site
866913004340	dimer interface [polypeptide binding]; other site
866913004341	H+/Cl- coupling transport residue; other site
866913004342	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
866913004343	hypothetical protein; Provisional; Region: PRK10578
866913004344	UPF0126 domain; Region: UPF0126; pfam03458
866913004345	UPF0126 domain; Region: UPF0126; pfam03458
866913004346	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
866913004347	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
866913004348	cobalamin binding residues [chemical binding]; other site
866913004349	putative BtuC binding residues; other site
866913004350	dimer interface [polypeptide binding]; other site
866913004351	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
866913004352	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
866913004353	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
866913004354	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866913004355	Zn2+ binding site [ion binding]; other site
866913004356	Mg2+ binding site [ion binding]; other site
866913004357	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
866913004358	serine endoprotease; Provisional; Region: PRK10942
866913004359	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866913004360	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866913004361	protein binding site [polypeptide binding]; other site
866913004362	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866913004363	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
866913004364	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
866913004365	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866913004366	hypothetical protein; Provisional; Region: PRK13677
866913004367	shikimate transporter; Provisional; Region: PRK09952
866913004368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913004369	putative substrate translocation pore; other site
866913004370	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
866913004371	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
866913004372	trimer interface [polypeptide binding]; other site
866913004373	active site
866913004374	substrate binding site [chemical binding]; other site
866913004375	CoA binding site [chemical binding]; other site
866913004376	PII uridylyl-transferase; Provisional; Region: PRK05007
866913004377	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866913004378	metal binding triad; other site
866913004379	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
866913004380	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866913004381	Zn2+ binding site [ion binding]; other site
866913004382	Mg2+ binding site [ion binding]; other site
866913004383	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
866913004384	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
866913004385	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
866913004386	active site
866913004387	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
866913004388	rRNA interaction site [nucleotide binding]; other site
866913004389	S8 interaction site; other site
866913004390	putative laminin-1 binding site; other site
866913004391	elongation factor Ts; Provisional; Region: tsf; PRK09377
866913004392	UBA/TS-N domain; Region: UBA; pfam00627
866913004393	Elongation factor TS; Region: EF_TS; pfam00889
866913004394	Elongation factor TS; Region: EF_TS; pfam00889
866913004395	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
866913004396	putative nucleotide binding site [chemical binding]; other site
866913004397	uridine monophosphate binding site [chemical binding]; other site
866913004398	homohexameric interface [polypeptide binding]; other site
866913004399	ribosome recycling factor; Reviewed; Region: frr; PRK00083
866913004400	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
866913004401	hinge region; other site
866913004402	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
866913004403	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
866913004404	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
866913004405	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
866913004406	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
866913004407	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
866913004408	catalytic residue [active]
866913004409	putative FPP diphosphate  binding site; other site
866913004410	putative FPP binding hydrophobic cleft; other site
866913004411	dimer interface [polypeptide binding]; other site
866913004412	putative IPP diphosphate binding site; other site
866913004413	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
866913004414	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
866913004415	zinc metallopeptidase RseP; Provisional; Region: PRK10779
866913004416	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
866913004417	active site
866913004418	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
866913004419	protein binding site [polypeptide binding]; other site
866913004420	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
866913004421	protein binding site [polypeptide binding]; other site
866913004422	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
866913004423	putative substrate binding region [chemical binding]; other site
866913004424	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
866913004425	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
866913004426	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
866913004427	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
866913004428	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
866913004429	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
866913004430	Surface antigen; Region: Bac_surface_Ag; pfam01103
866913004431	periplasmic chaperone; Provisional; Region: PRK10780
866913004432	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
866913004433	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
866913004434	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
866913004435	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
866913004436	trimer interface [polypeptide binding]; other site
866913004437	active site
866913004438	UDP-GlcNAc binding site [chemical binding]; other site
866913004439	lipid binding site [chemical binding]; lipid-binding site
866913004440	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
866913004441	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
866913004442	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
866913004443	active site
866913004444	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
866913004445	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
866913004446	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
866913004447	RNA/DNA hybrid binding site [nucleotide binding]; other site
866913004448	active site
866913004449	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
866913004450	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
866913004451	putative active site [active]
866913004452	putative PHP Thumb interface [polypeptide binding]; other site
866913004453	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
866913004454	generic binding surface II; other site
866913004455	generic binding surface I; other site
866913004456	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
866913004457	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
866913004458	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
866913004459	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
866913004460	putative sugar binding site [chemical binding]; other site
866913004461	catalytic residues [active]
866913004462	PKD domain; Region: PKD; pfam00801
866913004463	lysine decarboxylase LdcC; Provisional; Region: PRK15399
866913004464	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
866913004465	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
866913004466	homodimer interface [polypeptide binding]; other site
866913004467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913004468	catalytic residue [active]
866913004469	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
866913004470	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
866913004471	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866913004472	putative metal binding site [ion binding]; other site
866913004473	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
866913004474	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
866913004475	Ligand Binding Site [chemical binding]; other site
866913004476	TilS substrate binding domain; Region: TilS; pfam09179
866913004477	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
866913004478	Rho-binding antiterminator; Provisional; Region: PRK11625
866913004479	hypothetical protein; Provisional; Region: PRK04964
866913004480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
866913004481	hypothetical protein; Provisional; Region: PRK09256
866913004482	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
866913004483	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
866913004484	NlpE N-terminal domain; Region: NlpE; pfam04170
866913004485	prolyl-tRNA synthetase; Provisional; Region: PRK09194
866913004486	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
866913004487	dimer interface [polypeptide binding]; other site
866913004488	motif 1; other site
866913004489	active site
866913004490	motif 2; other site
866913004491	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
866913004492	putative deacylase active site [active]
866913004493	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866913004494	active site
866913004495	motif 3; other site
866913004496	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
866913004497	anticodon binding site; other site
866913004498	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
866913004499	homodimer interaction site [polypeptide binding]; other site
866913004500	cofactor binding site; other site
866913004501	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
866913004502	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
866913004503	lipoprotein, YaeC family; Region: TIGR00363
866913004504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913004505	dimer interface [polypeptide binding]; other site
866913004506	conserved gate region; other site
866913004507	ABC-ATPase subunit interface; other site
866913004508	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
866913004509	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866913004510	Walker A/P-loop; other site
866913004511	ATP binding site [chemical binding]; other site
866913004512	Q-loop/lid; other site
866913004513	ABC transporter signature motif; other site
866913004514	Walker B; other site
866913004515	D-loop; other site
866913004516	H-loop/switch region; other site
866913004517	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
866913004518	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
866913004519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913004520	active site
866913004521	motif I; other site
866913004522	motif II; other site
866913004523	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913004524	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913004525	active site
866913004526	catalytic tetrad [active]
866913004527	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913004528	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913004529	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
866913004530	putative effector binding pocket; other site
866913004531	dimerization interface [polypeptide binding]; other site
866913004532	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866913004533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913004534	putative substrate translocation pore; other site
866913004535	hypothetical protein; Provisional; Region: PRK05421
866913004536	putative catalytic site [active]
866913004537	putative metal binding site [ion binding]; other site
866913004538	putative phosphate binding site [ion binding]; other site
866913004539	putative catalytic site [active]
866913004540	putative phosphate binding site [ion binding]; other site
866913004541	putative metal binding site [ion binding]; other site
866913004542	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866913004543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913004544	S-adenosylmethionine binding site [chemical binding]; other site
866913004545	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
866913004546	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913004547	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913004548	catalytic residue [active]
866913004549	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913004550	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913004551	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
866913004552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913004553	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
866913004554	RNA/DNA hybrid binding site [nucleotide binding]; other site
866913004555	active site
866913004556	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
866913004557	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
866913004558	active site
866913004559	catalytic site [active]
866913004560	substrate binding site [chemical binding]; other site
866913004561	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
866913004562	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
866913004563	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
866913004564	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
866913004565	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
866913004566	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
866913004567	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
866913004568	ImpE protein; Region: ImpE; pfam07024
866913004569	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
866913004570	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913004571	Walker A motif; other site
866913004572	ATP binding site [chemical binding]; other site
866913004573	Walker B motif; other site
866913004574	arginine finger; other site
866913004575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913004576	Walker A motif; other site
866913004577	ATP binding site [chemical binding]; other site
866913004578	Walker B motif; other site
866913004579	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
866913004580	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
866913004581	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
866913004582	Protein of unknown function (DUF877); Region: DUF877; pfam05943
866913004583	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
866913004584	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
866913004585	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
866913004586	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
866913004587	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
866913004588	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
866913004589	hypothetical protein; Provisional; Region: PRK08126
866913004590	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
866913004591	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
866913004592	ligand binding site [chemical binding]; other site
866913004593	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
866913004594	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
866913004595	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
866913004596	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
866913004597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
866913004598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
866913004599	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
866913004600	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
866913004601	Uncharacterized conserved protein [Function unknown]; Region: COG5435
866913004602	PAAR motif; Region: PAAR_motif; pfam05488
866913004603	RHS Repeat; Region: RHS_repeat; pfam05593
866913004604	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
866913004605	RHS Repeat; Region: RHS_repeat; pfam05593
866913004606	RHS Repeat; Region: RHS_repeat; pfam05593
866913004607	RHS protein; Region: RHS; pfam03527
866913004608	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
866913004609	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
866913004610	RHS protein; Region: RHS; pfam03527
866913004611	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
866913004612	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
866913004613	Transposase; Region: HTH_Tnp_1; cl17663
866913004614	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
866913004615	Integrase core domain; Region: rve_3; pfam13683
866913004616	Saf-pilin pilus formation protein; Region: Saf-Nte_pilin; cl09697
866913004617	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
866913004618	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913004619	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913004620	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
866913004621	PapC N-terminal domain; Region: PapC_N; pfam13954
866913004622	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913004623	PapC C-terminal domain; Region: PapC_C; pfam13953
866913004624	putative pilin structural protein SafD; Provisional; Region: PRK15222
866913004625	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
866913004626	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
866913004627	putative active site [active]
866913004628	putative metal binding site [ion binding]; other site
866913004629	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913004630	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913004631	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913004632	dimerization interface [polypeptide binding]; other site
866913004633	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
866913004634	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
866913004635	dimer interface [polypeptide binding]; other site
866913004636	C-N hydrolase family amidase; Provisional; Region: PRK10438
866913004637	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
866913004638	putative active site [active]
866913004639	catalytic triad [active]
866913004640	dimer interface [polypeptide binding]; other site
866913004641	multimer interface [polypeptide binding]; other site
866913004642	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
866913004643	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866913004644	active site
866913004645	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
866913004646	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
866913004647	dimer interface [polypeptide binding]; other site
866913004648	active site
866913004649	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
866913004650	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
866913004651	putative active site [active]
866913004652	putative dimer interface [polypeptide binding]; other site
866913004653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
866913004654	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866913004655	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
866913004656	active site
866913004657	DNA polymerase IV; Validated; Region: PRK02406
866913004658	DNA binding site [nucleotide binding]
866913004659	Uncharacterized protein family UPF0027; Region: UPF0027; cl17455
866913004660	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
866913004661	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
866913004662	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
866913004663	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
866913004664	metal binding site [ion binding]; metal-binding site
866913004665	dimer interface [polypeptide binding]; other site
866913004666	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913004667	active site
866913004668	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
866913004669	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
866913004670	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913004671	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
866913004672	trimer interface [polypeptide binding]; other site
866913004673	eyelet of channel; other site
866913004674	gamma-glutamyl kinase; Provisional; Region: PRK05429
866913004675	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
866913004676	nucleotide binding site [chemical binding]; other site
866913004677	homotetrameric interface [polypeptide binding]; other site
866913004678	putative phosphate binding site [ion binding]; other site
866913004679	putative allosteric binding site; other site
866913004680	PUA domain; Region: PUA; pfam01472
866913004681	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
866913004682	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
866913004683	putative catalytic cysteine [active]
866913004684	HTH-like domain; Region: HTH_21; pfam13276
866913004685	Integrase core domain; Region: rve; pfam00665
866913004686	Integrase core domain; Region: rve_2; pfam13333
866913004687	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
866913004688	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866913004689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913004690	putative substrate translocation pore; other site
866913004691	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
866913004692	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
866913004693	substrate binding site [chemical binding]; other site
866913004694	ligand binding site [chemical binding]; other site
866913004695	3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066
866913004696	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
866913004697	hypothetical protein; Provisional; Region: PRK14812
866913004698	substrate binding site [chemical binding]; other site
866913004699	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
866913004700	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
866913004701	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866913004702	transcriptional activator TtdR; Provisional; Region: PRK09801
866913004703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913004704	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
866913004705	putative effector binding pocket; other site
866913004706	putative dimerization interface [polypeptide binding]; other site
866913004707	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
866913004708	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913004709	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913004710	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
866913004711	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
866913004712	PapC N-terminal domain; Region: PapC_N; pfam13954
866913004713	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913004714	PapC C-terminal domain; Region: PapC_C; pfam13953
866913004715	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913004716	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913004717	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
866913004718	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
866913004719	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
866913004720	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913004721	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
866913004722	DNA binding site [nucleotide binding]
866913004723	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
866913004724	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
866913004725	DNA binding residues [nucleotide binding]
866913004726	dimerization interface [polypeptide binding]; other site
866913004727	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
866913004728	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
866913004729	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
866913004730	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
866913004731	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913004732	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913004733	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866913004734	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866913004735	metal-binding site [ion binding]
866913004736	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866913004737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913004738	motif II; other site
866913004739	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
866913004740	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
866913004741	DNA binding residues [nucleotide binding]
866913004742	dimer interface [polypeptide binding]; other site
866913004743	copper binding site [ion binding]; other site
866913004744	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866913004745	metal-binding site [ion binding]
866913004746	putative sialic acid transporter; Region: 2A0112; TIGR00891
866913004747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913004748	putative substrate translocation pore; other site
866913004749	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
866913004750	DNA methylase; Region: N6_N4_Mtase; cl17433
866913004751	DNA methylase; Region: N6_N4_Mtase; pfam01555
866913004752	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
866913004753	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
866913004754	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866913004755	VRR-NUC domain; Region: VRR_NUC; pfam08774
866913004756	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
866913004757	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
866913004758	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
866913004759	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
866913004760	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913004761	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
866913004762	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913004763	N-terminal plug; other site
866913004764	ligand-binding site [chemical binding]; other site
866913004765	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
866913004766	hypothetical protein; Provisional; Region: PRK09929
866913004767	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
866913004768	Propionate catabolism activator; Region: PrpR_N; pfam06506
866913004769	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913004770	Walker A motif; other site
866913004771	ATP binding site [chemical binding]; other site
866913004772	Walker B motif; other site
866913004773	arginine finger; other site
866913004774	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866913004775	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
866913004776	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
866913004777	tetramer interface [polypeptide binding]; other site
866913004778	active site
866913004779	Mg2+/Mn2+ binding site [ion binding]; other site
866913004780	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
866913004781	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
866913004782	dimer interface [polypeptide binding]; other site
866913004783	active site
866913004784	citrylCoA binding site [chemical binding]; other site
866913004785	oxalacetate/citrate binding site [chemical binding]; other site
866913004786	coenzyme A binding site [chemical binding]; other site
866913004787	catalytic triad [active]
866913004788	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
866913004789	2-methylcitrate dehydratase; Region: prpD; TIGR02330
866913004790	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
866913004791	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
866913004792	acyl-activating enzyme (AAE) consensus motif; other site
866913004793	AMP binding site [chemical binding]; other site
866913004794	active site
866913004795	CoA binding site [chemical binding]; other site
866913004796	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
866913004797	dimer interface [polypeptide binding]; other site
866913004798	active site
866913004799	Schiff base residues; other site
866913004800	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
866913004801	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
866913004802	Autotransporter beta-domain; Region: Autotransporter; pfam03797
866913004803	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
866913004804	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866913004805	ligand binding site [chemical binding]; other site
866913004806	flexible hinge region; other site
866913004807	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
866913004808	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
866913004809	microcin B17 transporter; Reviewed; Region: PRK11098
866913004810	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
866913004811	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
866913004812	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
866913004813	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
866913004814	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
866913004815	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
866913004816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
866913004817	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
866913004818	drug efflux system protein MdtG; Provisional; Region: PRK09874
866913004819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913004820	putative substrate translocation pore; other site
866913004821	anti-RssB factor; Provisional; Region: PRK10244
866913004822	hypothetical protein; Provisional; Region: PRK11505
866913004823	psiF repeat; Region: PsiF_repeat; pfam07769
866913004824	psiF repeat; Region: PsiF_repeat; pfam07769
866913004825	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
866913004826	MASE2 domain; Region: MASE2; pfam05230
866913004827	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913004828	metal binding site [ion binding]; metal-binding site
866913004829	active site
866913004830	I-site; other site
866913004831	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
866913004832	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
866913004833	hypothetical protein; Validated; Region: PRK00124
866913004834	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
866913004835	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
866913004836	ADP binding site [chemical binding]; other site
866913004837	magnesium binding site [ion binding]; other site
866913004838	putative shikimate binding site; other site
866913004839	hypothetical protein; Provisional; Region: PRK10380
866913004840	hypothetical protein; Provisional; Region: PRK10481
866913004841	hypothetical protein; Provisional; Region: PRK10579
866913004842	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
866913004843	fructokinase; Reviewed; Region: PRK09557
866913004844	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913004845	nucleotide binding site [chemical binding]; other site
866913004846	MFS transport protein AraJ; Provisional; Region: PRK10091
866913004847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913004848	putative substrate translocation pore; other site
866913004849	exonuclease subunit SbcC; Provisional; Region: PRK10246
866913004850	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913004851	Walker A/P-loop; other site
866913004852	ATP binding site [chemical binding]; other site
866913004853	Q-loop/lid; other site
866913004854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913004855	ABC transporter signature motif; other site
866913004856	Walker B; other site
866913004857	D-loop; other site
866913004858	H-loop/switch region; other site
866913004859	exonuclease subunit SbcD; Provisional; Region: PRK10966
866913004860	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
866913004861	active site
866913004862	metal binding site [ion binding]; metal-binding site
866913004863	DNA binding site [nucleotide binding]
866913004864	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
866913004865	transcriptional regulator PhoB; Provisional; Region: PRK10161
866913004866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913004867	active site
866913004868	phosphorylation site [posttranslational modification]
866913004869	intermolecular recognition site; other site
866913004870	dimerization interface [polypeptide binding]; other site
866913004871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913004872	DNA binding site [nucleotide binding]
866913004873	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
866913004874	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
866913004875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913004876	putative active site [active]
866913004877	heme pocket [chemical binding]; other site
866913004878	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913004879	dimer interface [polypeptide binding]; other site
866913004880	phosphorylation site [posttranslational modification]
866913004881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913004882	ATP binding site [chemical binding]; other site
866913004883	Mg2+ binding site [ion binding]; other site
866913004884	G-X-G motif; other site
866913004885	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
866913004886	putative proline-specific permease; Provisional; Region: proY; PRK10580
866913004887	maltodextrin glucosidase; Provisional; Region: PRK10785
866913004888	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
866913004889	homodimer interface [polypeptide binding]; other site
866913004890	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
866913004891	active site
866913004892	homodimer interface [polypeptide binding]; other site
866913004893	catalytic site [active]
866913004894	peroxidase; Provisional; Region: PRK15000
866913004895	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
866913004896	dimer interface [polypeptide binding]; other site
866913004897	decamer (pentamer of dimers) interface [polypeptide binding]; other site
866913004898	catalytic triad [active]
866913004899	peroxidatic and resolving cysteines [active]
866913004900	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
866913004901	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
866913004902	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
866913004903	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
866913004904	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
866913004905	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
866913004906	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
866913004907	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
866913004908	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
866913004909	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
866913004910	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
866913004911	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
866913004912	Protein export membrane protein; Region: SecD_SecF; pfam02355
866913004913	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
866913004914	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866913004915	Predicted transcriptional regulator [Transcription]; Region: COG2378
866913004916	HTH domain; Region: HTH_11; pfam08279
866913004917	WYL domain; Region: WYL; pfam13280
866913004918	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
866913004919	active site
866913004920	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
866913004921	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
866913004922	hypothetical protein; Provisional; Region: PRK11530
866913004923	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
866913004924	ATP cone domain; Region: ATP-cone; pfam03477
866913004925	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
866913004926	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
866913004927	catalytic motif [active]
866913004928	Zn binding site [ion binding]; other site
866913004929	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
866913004930	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
866913004931	homopentamer interface [polypeptide binding]; other site
866913004932	active site
866913004933	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
866913004934	putative RNA binding site [nucleotide binding]; other site
866913004935	thiamine monophosphate kinase; Provisional; Region: PRK05731
866913004936	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
866913004937	ATP binding site [chemical binding]; other site
866913004938	dimerization interface [polypeptide binding]; other site
866913004939	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
866913004940	tetramer interfaces [polypeptide binding]; other site
866913004941	binuclear metal-binding site [ion binding]; other site
866913004942	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913004943	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913004944	active site
866913004945	catalytic tetrad [active]
866913004946	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
866913004947	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
866913004948	TPP-binding site; other site
866913004949	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866913004950	PYR/PP interface [polypeptide binding]; other site
866913004951	dimer interface [polypeptide binding]; other site
866913004952	TPP binding site [chemical binding]; other site
866913004953	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866913004954	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
866913004955	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
866913004956	substrate binding pocket [chemical binding]; other site
866913004957	chain length determination region; other site
866913004958	substrate-Mg2+ binding site; other site
866913004959	catalytic residues [active]
866913004960	aspartate-rich region 1; other site
866913004961	active site lid residues [active]
866913004962	aspartate-rich region 2; other site
866913004963	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
866913004964	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
866913004965	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
866913004966	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
866913004967	Ligand Binding Site [chemical binding]; other site
866913004968	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866913004969	active site residue [active]
866913004970	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
866913004971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913004972	dimer interface [polypeptide binding]; other site
866913004973	conserved gate region; other site
866913004974	ABC-ATPase subunit interface; other site
866913004975	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
866913004976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913004977	dimer interface [polypeptide binding]; other site
866913004978	conserved gate region; other site
866913004979	putative PBP binding loops; other site
866913004980	ABC-ATPase subunit interface; other site
866913004981	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
866913004982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913004983	Walker A/P-loop; other site
866913004984	ATP binding site [chemical binding]; other site
866913004985	Q-loop/lid; other site
866913004986	ABC transporter signature motif; other site
866913004987	Walker B; other site
866913004988	D-loop; other site
866913004989	H-loop/switch region; other site
866913004990	TOBE domain; Region: TOBE_2; pfam08402
866913004991	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
866913004992	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
866913004993	transcriptional regulator protein; Region: phnR; TIGR03337
866913004994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913004995	DNA-binding site [nucleotide binding]; DNA binding site
866913004996	UTRA domain; Region: UTRA; pfam07702
866913004997	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
866913004998	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913004999	catalytic residue [active]
866913005000	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
866913005001	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913005002	motif II; other site
866913005003	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
866913005004	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
866913005005	conserved cys residue [active]
866913005006	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
866913005007	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
866913005008	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
866913005009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
866913005010	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
866913005011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913005012	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913005013	putative substrate translocation pore; other site
866913005014	Sel1-like repeats; Region: SEL1; smart00671
866913005015	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913005016	Sel1 repeat; Region: Sel1; pfam08238
866913005017	Sel1-like repeats; Region: SEL1; smart00671
866913005018	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913005019	Sel1-like repeats; Region: SEL1; smart00671
866913005020	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913005021	Sel1-like repeats; Region: SEL1; smart00671
866913005022	Sel1-like repeats; Region: SEL1; smart00671
866913005023	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
866913005024	UbiA prenyltransferase family; Region: UbiA; pfam01040
866913005025	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
866913005026	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
866913005027	Subunit I/III interface [polypeptide binding]; other site
866913005028	Subunit III/IV interface [polypeptide binding]; other site
866913005029	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
866913005030	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
866913005031	D-pathway; other site
866913005032	Putative ubiquinol binding site [chemical binding]; other site
866913005033	Low-spin heme (heme b) binding site [chemical binding]; other site
866913005034	Putative water exit pathway; other site
866913005035	Binuclear center (heme o3/CuB) [ion binding]; other site
866913005036	K-pathway; other site
866913005037	Putative proton exit pathway; other site
866913005038	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
866913005039	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
866913005040	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
866913005041	muropeptide transporter; Reviewed; Region: ampG; PRK11902
866913005042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913005043	putative substrate translocation pore; other site
866913005044	hypothetical protein; Provisional; Region: PRK11627
866913005045	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
866913005046	transcriptional regulator BolA; Provisional; Region: PRK11628
866913005047	trigger factor; Provisional; Region: tig; PRK01490
866913005048	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866913005049	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
866913005050	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
866913005051	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
866913005052	oligomer interface [polypeptide binding]; other site
866913005053	active site residues [active]
866913005054	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
866913005055	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
866913005056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913005057	Walker A motif; other site
866913005058	ATP binding site [chemical binding]; other site
866913005059	Walker B motif; other site
866913005060	Iron permease FTR1 family; Region: FTR1; cl00475
866913005061	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
866913005062	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
866913005063	Found in ATP-dependent protease La (LON); Region: LON; smart00464
866913005064	Found in ATP-dependent protease La (LON); Region: LON; smart00464
866913005065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913005066	Walker A motif; other site
866913005067	ATP binding site [chemical binding]; other site
866913005068	Walker B motif; other site
866913005069	arginine finger; other site
866913005070	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
866913005071	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
866913005072	IHF dimer interface [polypeptide binding]; other site
866913005073	IHF - DNA interface [nucleotide binding]; other site
866913005074	periplasmic folding chaperone; Provisional; Region: PRK10788
866913005075	SurA N-terminal domain; Region: SurA_N_3; cl07813
866913005076	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
866913005077	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
866913005078	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
866913005079	active site
866913005080	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
866913005081	Ligand Binding Site [chemical binding]; other site
866913005082	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
866913005083	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
866913005084	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
866913005085	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
866913005086	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913005087	active site
866913005088	motif I; other site
866913005089	motif II; other site
866913005090	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866913005091	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
866913005092	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913005093	catalytic residue [active]
866913005094	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
866913005095	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913005096	putative DNA binding site [nucleotide binding]; other site
866913005097	putative Zn2+ binding site [ion binding]; other site
866913005098	AsnC family; Region: AsnC_trans_reg; pfam01037
866913005099	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
866913005100	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913005101	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913005102	Walker A/P-loop; other site
866913005103	ATP binding site [chemical binding]; other site
866913005104	Q-loop/lid; other site
866913005105	ABC transporter signature motif; other site
866913005106	Walker B; other site
866913005107	D-loop; other site
866913005108	H-loop/switch region; other site
866913005109	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
866913005110	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913005111	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913005112	Walker A/P-loop; other site
866913005113	ATP binding site [chemical binding]; other site
866913005114	Q-loop/lid; other site
866913005115	ABC transporter signature motif; other site
866913005116	Walker B; other site
866913005117	D-loop; other site
866913005118	H-loop/switch region; other site
866913005119	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
866913005120	Nitrogen regulatory protein P-II; Region: P-II; smart00938
866913005121	ammonium transporter; Provisional; Region: PRK10666
866913005122	acyl-CoA thioesterase II; Provisional; Region: PRK10526
866913005123	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
866913005124	active site
866913005125	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
866913005126	catalytic triad [active]
866913005127	dimer interface [polypeptide binding]; other site
866913005128	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
866913005129	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
866913005130	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
866913005131	DNA binding site [nucleotide binding]
866913005132	active site
866913005133	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
866913005134	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
866913005135	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913005136	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
866913005137	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
866913005138	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
866913005139	maltose O-acetyltransferase; Provisional; Region: PRK10092
866913005140	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
866913005141	active site
866913005142	substrate binding site [chemical binding]; other site
866913005143	trimer interface [polypeptide binding]; other site
866913005144	CoA binding site [chemical binding]; other site
866913005145	gene expression modulator; Provisional; Region: PRK10945
866913005146	Hha toxicity attenuator; Provisional; Region: PRK10667
866913005147	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
866913005148	Protein export membrane protein; Region: SecD_SecF; cl14618
866913005149	Protein export membrane protein; Region: SecD_SecF; cl14618
866913005150	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
866913005151	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913005152	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
866913005153	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913005154	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
866913005155	hypothetical protein; Provisional; Region: PRK11281
866913005156	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
866913005157	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
866913005158	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913005159	Uncharacterized conserved protein [Function unknown]; Region: COG5464
866913005160	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
866913005161	hypothetical protein; Provisional; Region: PRK11038
866913005162	primosomal replication protein N''; Provisional; Region: PRK10093
866913005163	hypothetical protein; Provisional; Region: PRK10527
866913005164	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913005165	active site
866913005166	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
866913005167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913005168	Walker A motif; other site
866913005169	ATP binding site [chemical binding]; other site
866913005170	Walker B motif; other site
866913005171	DNA polymerase III subunit delta'; Validated; Region: PRK08485
866913005172	arginine finger; other site
866913005173	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
866913005174	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
866913005175	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
866913005176	hypothetical protein; Validated; Region: PRK00153
866913005177	recombination protein RecR; Reviewed; Region: recR; PRK00076
866913005178	RecR protein; Region: RecR; pfam02132
866913005179	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
866913005180	putative active site [active]
866913005181	putative metal-binding site [ion binding]; other site
866913005182	tetramer interface [polypeptide binding]; other site
866913005183	heat shock protein 90; Provisional; Region: PRK05218
866913005184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913005185	ATP binding site [chemical binding]; other site
866913005186	Mg2+ binding site [ion binding]; other site
866913005187	G-X-G motif; other site
866913005188	adenylate kinase; Reviewed; Region: adk; PRK00279
866913005189	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
866913005190	AMP-binding site [chemical binding]; other site
866913005191	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
866913005192	ferrochelatase; Reviewed; Region: hemH; PRK00035
866913005193	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
866913005194	C-terminal domain interface [polypeptide binding]; other site
866913005195	active site
866913005196	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
866913005197	active site
866913005198	N-terminal domain interface [polypeptide binding]; other site
866913005199	acetyl esterase; Provisional; Region: PRK10162
866913005200	putative cation:proton antiport protein; Provisional; Region: PRK10669
866913005201	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
866913005202	TrkA-N domain; Region: TrkA_N; pfam02254
866913005203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913005204	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913005205	putative substrate translocation pore; other site
866913005206	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
866913005207	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
866913005208	active site
866913005209	metal binding site [ion binding]; metal-binding site
866913005210	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866913005211	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
866913005212	putative deacylase active site [active]
866913005213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
866913005214	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
866913005215	copper exporting ATPase; Provisional; Region: copA; PRK10671
866913005216	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866913005217	metal-binding site [ion binding]
866913005218	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866913005219	metal-binding site [ion binding]
866913005220	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866913005221	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913005222	motif II; other site
866913005223	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
866913005224	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
866913005225	DNA binding residues [nucleotide binding]
866913005226	dimer interface [polypeptide binding]; other site
866913005227	copper binding site [ion binding]; other site
866913005228	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
866913005229	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
866913005230	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
866913005231	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
866913005232	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
866913005233	Walker A/P-loop; other site
866913005234	ATP binding site [chemical binding]; other site
866913005235	Q-loop/lid; other site
866913005236	ABC transporter signature motif; other site
866913005237	Walker B; other site
866913005238	D-loop; other site
866913005239	H-loop/switch region; other site
866913005240	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
866913005241	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
866913005242	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
866913005243	oxidoreductase; Provisional; Region: PRK08017
866913005244	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
866913005245	NADP binding site [chemical binding]; other site
866913005246	active site
866913005247	steroid binding site; other site
866913005248	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
866913005249	active site
866913005250	catalytic triad [active]
866913005251	oxyanion hole [active]
866913005252	switch loop; other site
866913005253	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
866913005254	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866913005255	Walker A/P-loop; other site
866913005256	ATP binding site [chemical binding]; other site
866913005257	Q-loop/lid; other site
866913005258	ABC transporter signature motif; other site
866913005259	Walker B; other site
866913005260	D-loop; other site
866913005261	H-loop/switch region; other site
866913005262	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
866913005263	FtsX-like permease family; Region: FtsX; pfam02687
866913005264	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913005265	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
866913005266	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
866913005267	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866913005268	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
866913005269	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866913005270	Walker A/P-loop; other site
866913005271	ATP binding site [chemical binding]; other site
866913005272	Q-loop/lid; other site
866913005273	ABC transporter signature motif; other site
866913005274	Walker B; other site
866913005275	D-loop; other site
866913005276	H-loop/switch region; other site
866913005277	NIL domain; Region: NIL; pfam09383
866913005278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913005279	dimer interface [polypeptide binding]; other site
866913005280	conserved gate region; other site
866913005281	ABC-ATPase subunit interface; other site
866913005282	Predicted ATPase [General function prediction only]; Region: COG2603
866913005283	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
866913005284	active site residue [active]
866913005285	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
866913005286	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913005287	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913005288	dimerization interface [polypeptide binding]; other site
866913005289	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
866913005290	ureidoglycolate hydrolase; Provisional; Region: PRK03606
866913005291	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
866913005292	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
866913005293	Bacterial transcriptional regulator; Region: IclR; pfam01614
866913005294	glyoxylate carboligase; Provisional; Region: PRK11269
866913005295	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866913005296	PYR/PP interface [polypeptide binding]; other site
866913005297	dimer interface [polypeptide binding]; other site
866913005298	TPP binding site [chemical binding]; other site
866913005299	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866913005300	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
866913005301	TPP-binding site [chemical binding]; other site
866913005302	hydroxypyruvate isomerase; Provisional; Region: PRK09997
866913005303	tartronate semialdehyde reductase; Provisional; Region: PRK15059
866913005304	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866913005305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913005306	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913005307	putative substrate translocation pore; other site
866913005308	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
866913005309	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
866913005310	Na binding site [ion binding]; other site
866913005311	putative substrate binding site [chemical binding]; other site
866913005312	allantoinase; Provisional; Region: PRK08044
866913005313	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
866913005314	active site
866913005315	putative uracil/xanthine transporter; Provisional; Region: PRK11412
866913005316	glycerate kinase II; Provisional; Region: PRK09932
866913005317	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
866913005318	Mif2/CENP-C like; Region: Mif2; pfam11699
866913005319	Cupin domain; Region: Cupin_2; pfam07883
866913005320	allantoate amidohydrolase; Region: AllC; TIGR03176
866913005321	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
866913005322	active site
866913005323	metal binding site [ion binding]; metal-binding site
866913005324	dimer interface [polypeptide binding]; other site
866913005325	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
866913005326	membrane protein FdrA; Validated; Region: PRK06091
866913005327	CoA binding domain; Region: CoA_binding; pfam02629
866913005328	CoA-ligase; Region: Ligase_CoA; pfam00549
866913005329	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
866913005330	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
866913005331	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
866913005332	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
866913005333	putative substrate binding site [chemical binding]; other site
866913005334	nucleotide binding site [chemical binding]; other site
866913005335	nucleotide binding site [chemical binding]; other site
866913005336	homodimer interface [polypeptide binding]; other site
866913005337	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
866913005338	ATP-grasp domain; Region: ATP-grasp; pfam02222
866913005339	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
866913005340	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
866913005341	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866913005342	putative active site [active]
866913005343	putative metal binding site [ion binding]; other site
866913005344	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
866913005345	substrate binding site [chemical binding]; other site
866913005346	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
866913005347	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866913005348	active site
866913005349	HIGH motif; other site
866913005350	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866913005351	KMSKS motif; other site
866913005352	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
866913005353	tRNA binding surface [nucleotide binding]; other site
866913005354	anticodon binding site; other site
866913005355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
866913005356	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
866913005357	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
866913005358	ribosome-associated protein; Provisional; Region: PRK11507
866913005359	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
866913005360	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
866913005361	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
866913005362	homodimer interface [polypeptide binding]; other site
866913005363	NADP binding site [chemical binding]; other site
866913005364	substrate binding site [chemical binding]; other site
866913005365	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
866913005366	fimbrial protein FimI; Provisional; Region: PRK15200
866913005367	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
866913005368	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913005369	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913005370	outer membrane usher protein FimD; Provisional; Region: PRK15198
866913005371	PapC N-terminal domain; Region: PapC_N; pfam13954
866913005372	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913005373	PapC C-terminal domain; Region: PapC_C; pfam13953
866913005374	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
866913005375	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
866913005376	transcriptional regulator FimZ; Provisional; Region: PRK09935
866913005377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913005378	active site
866913005379	phosphorylation site [posttranslational modification]
866913005380	intermolecular recognition site; other site
866913005381	dimerization interface [polypeptide binding]; other site
866913005382	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913005383	DNA binding residues [nucleotide binding]
866913005384	dimerization interface [polypeptide binding]; other site
866913005385	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
866913005386	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913005387	DNA binding residues [nucleotide binding]
866913005388	dimerization interface [polypeptide binding]; other site
866913005389	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866913005390	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
866913005391	Ligand binding site; other site
866913005392	Putative Catalytic site; other site
866913005393	DXD motif; other site
866913005394	Predicted membrane protein [Function unknown]; Region: COG2246
866913005395	GtrA-like protein; Region: GtrA; pfam04138
866913005396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913005397	ATP binding site [chemical binding]; other site
866913005398	Mg2+ binding site [ion binding]; other site
866913005399	G-X-G motif; other site
866913005400	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
866913005401	Cupin; Region: Cupin_6; pfam12852
866913005402	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
866913005403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913005404	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913005405	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
866913005406	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913005407	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866913005408	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913005409	Predicted membrane protein [Function unknown]; Region: COG3059
866913005410	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
866913005411	phenylalanine transporter; Provisional; Region: PRK10249
866913005412	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866913005413	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913005414	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
866913005415	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
866913005416	active site
866913005417	oxyanion hole [active]
866913005418	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
866913005419	catalytic triad [active]
866913005420	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
866913005421	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
866913005422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913005423	ATP binding site [chemical binding]; other site
866913005424	Walker B motif; other site
866913005425	arginine finger; other site
866913005426	Transcriptional antiterminator [Transcription]; Region: COG3933
866913005427	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866913005428	active pocket/dimerization site; other site
866913005429	active site
866913005430	phosphorylation site [posttranslational modification]
866913005431	PRD domain; Region: PRD; pfam00874
866913005432	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
866913005433	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
866913005434	putative active site [active]
866913005435	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866913005436	dimer interface [polypeptide binding]; other site
866913005437	active site
866913005438	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
866913005439	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
866913005440	dimer interface [polypeptide binding]; other site
866913005441	active site
866913005442	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866913005443	dimer interface [polypeptide binding]; other site
866913005444	active site
866913005445	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
866913005446	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
866913005447	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
866913005448	active site
866913005449	phosphorylation site [posttranslational modification]
866913005450	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866913005451	active pocket/dimerization site; other site
866913005452	active site
866913005453	phosphorylation site [posttranslational modification]
866913005454	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
866913005455	dimer interface [polypeptide binding]; other site
866913005456	FMN binding site [chemical binding]; other site
866913005457	hypothetical protein; Provisional; Region: PRK10250
866913005458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866913005459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913005460	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
866913005461	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913005462	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
866913005463	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
866913005464	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
866913005465	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
866913005466	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
866913005467	outer membrane receptor FepA; Provisional; Region: PRK13524
866913005468	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913005469	N-terminal plug; other site
866913005470	ligand-binding site [chemical binding]; other site
866913005471	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
866913005472	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
866913005473	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
866913005474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
866913005475	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
866913005476	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
866913005477	acyl-activating enzyme (AAE) consensus motif; other site
866913005478	AMP binding site [chemical binding]; other site
866913005479	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
866913005480	LPS O-antigen length regulator; Provisional; Region: PRK10381
866913005481	Chain length determinant protein; Region: Wzz; pfam02706
866913005482	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
866913005483	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866913005484	Walker A/P-loop; other site
866913005485	ATP binding site [chemical binding]; other site
866913005486	Q-loop/lid; other site
866913005487	ABC transporter signature motif; other site
866913005488	Walker B; other site
866913005489	D-loop; other site
866913005490	H-loop/switch region; other site
866913005491	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
866913005492	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913005493	ABC-ATPase subunit  interface; other site
866913005494	dimer interface [polypeptide binding]; other site
866913005495	putative PBP binding regions; other site
866913005496	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866913005497	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913005498	ABC-ATPase subunit  interface; other site
866913005499	dimer interface [polypeptide binding]; other site
866913005500	putative PBP binding regions; other site
866913005501	enterobactin exporter EntS; Provisional; Region: PRK10489
866913005502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913005503	putative substrate translocation pore; other site
866913005504	ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592
866913005505	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
866913005506	siderophore binding site; other site
866913005507	isochorismate synthase EntC; Provisional; Region: PRK15016
866913005508	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
866913005509	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
866913005510	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
866913005511	acyl-activating enzyme (AAE) consensus motif; other site
866913005512	active site
866913005513	AMP binding site [chemical binding]; other site
866913005514	substrate binding site [chemical binding]; other site
866913005515	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
866913005516	hydrophobic substrate binding pocket; other site
866913005517	Isochorismatase family; Region: Isochorismatase; pfam00857
866913005518	active site
866913005519	conserved cis-peptide bond; other site
866913005520	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
866913005521	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
866913005522	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
866913005523	putative NAD(P) binding site [chemical binding]; other site
866913005524	active site
866913005525	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
866913005526	CoenzymeA binding site [chemical binding]; other site
866913005527	subunit interaction site [polypeptide binding]; other site
866913005528	PHB binding site; other site
866913005529	carbon starvation protein A; Provisional; Region: PRK15015
866913005530	Carbon starvation protein CstA; Region: CstA; pfam02554
866913005531	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
866913005532	Uncharacterized small protein [Function unknown]; Region: COG2879
866913005533	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
866913005534	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
866913005535	putative active site [active]
866913005536	metal binding site [ion binding]; metal-binding site
866913005537	methionine aminotransferase; Validated; Region: PRK09082
866913005538	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913005539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913005540	homodimer interface [polypeptide binding]; other site
866913005541	catalytic residue [active]
866913005542	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
866913005543	ParB-like nuclease domain; Region: ParBc; pfam02195
866913005544	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
866913005545	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
866913005546	Active Sites [active]
866913005547	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
866913005548	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
866913005549	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913005550	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913005551	dimerization interface [polypeptide binding]; other site
866913005552	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
866913005553	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
866913005554	dimerization domain [polypeptide binding]; other site
866913005555	dimer interface [polypeptide binding]; other site
866913005556	catalytic residues [active]
866913005557	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
866913005558	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
866913005559	dimer interface [polypeptide binding]; other site
866913005560	decamer (pentamer of dimers) interface [polypeptide binding]; other site
866913005561	catalytic triad [active]
866913005562	peroxidatic and resolving cysteines [active]
866913005563	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
866913005564	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
866913005565	catalytic residue [active]
866913005566	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
866913005567	catalytic residues [active]
866913005568	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913005569	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913005570	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
866913005571	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
866913005572	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
866913005573	putative [4Fe-4S] binding site [ion binding]; other site
866913005574	putative molybdopterin cofactor binding site [chemical binding]; other site
866913005575	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
866913005576	molybdopterin cofactor binding site; other site
866913005577	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
866913005578	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
866913005579	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866913005580	Ligand Binding Site [chemical binding]; other site
866913005581	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
866913005582	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
866913005583	NAD binding site [chemical binding]; other site
866913005584	catalytic Zn binding site [ion binding]; other site
866913005585	structural Zn binding site [ion binding]; other site
866913005586	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
866913005587	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
866913005588	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
866913005589	B1 nucleotide binding pocket [chemical binding]; other site
866913005590	B2 nucleotide binding pocket [chemical binding]; other site
866913005591	CAS motifs; other site
866913005592	active site
866913005593	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
866913005594	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
866913005595	transmembrane helices; other site
866913005596	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
866913005597	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
866913005598	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
866913005599	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
866913005600	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
866913005601	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
866913005602	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
866913005603	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
866913005604	putative active site [active]
866913005605	(T/H)XGH motif; other site
866913005606	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
866913005607	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913005608	putative active site [active]
866913005609	heme pocket [chemical binding]; other site
866913005610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913005611	ATP binding site [chemical binding]; other site
866913005612	Mg2+ binding site [ion binding]; other site
866913005613	G-X-G motif; other site
866913005614	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
866913005615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913005616	active site
866913005617	phosphorylation site [posttranslational modification]
866913005618	intermolecular recognition site; other site
866913005619	dimerization interface [polypeptide binding]; other site
866913005620	Transcriptional regulator; Region: CitT; pfam12431
866913005621	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
866913005622	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
866913005623	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
866913005624	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866913005625	DNA-binding site [nucleotide binding]; DNA binding site
866913005626	RNA-binding motif; other site
866913005627	chromosome condensation membrane protein; Provisional; Region: PRK14196
866913005628	Predicted amidohydrolase [General function prediction only]; Region: COG0388
866913005629	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
866913005630	putative active site [active]
866913005631	catalytic triad [active]
866913005632	putative dimer interface [polypeptide binding]; other site
866913005633	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
866913005634	lipoyl synthase; Provisional; Region: PRK05481
866913005635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913005636	FeS/SAM binding site; other site
866913005637	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
866913005638	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913005639	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
866913005640	substrate binding pocket [chemical binding]; other site
866913005641	dimerization interface [polypeptide binding]; other site
866913005642	lipoate-protein ligase B; Provisional; Region: PRK14342
866913005643	hypothetical protein; Provisional; Region: PRK04998
866913005644	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
866913005645	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866913005646	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
866913005647	rare lipoprotein A; Provisional; Region: PRK10672
866913005648	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
866913005649	Sporulation related domain; Region: SPOR; pfam05036
866913005650	cell wall shape-determining protein; Provisional; Region: PRK10794
866913005651	penicillin-binding protein 2; Provisional; Region: PRK10795
866913005652	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866913005653	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866913005654	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
866913005655	ribosome-associated protein; Provisional; Region: PRK11538
866913005656	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866913005657	catalytic core [active]
866913005658	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
866913005659	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913005660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913005661	homodimer interface [polypeptide binding]; other site
866913005662	catalytic residue [active]
866913005663	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
866913005664	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
866913005665	active site
866913005666	(T/H)XGH motif; other site
866913005667	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
866913005668	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
866913005669	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
866913005670	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
866913005671	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
866913005672	HIGH motif; other site
866913005673	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
866913005674	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866913005675	active site
866913005676	KMSKS motif; other site
866913005677	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
866913005678	tRNA binding surface [nucleotide binding]; other site
866913005679	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
866913005680	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
866913005681	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
866913005682	Propionate catabolism activator; Region: PrpR_N; pfam06506
866913005683	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
866913005684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913005685	Walker A motif; other site
866913005686	ATP binding site [chemical binding]; other site
866913005687	Walker B motif; other site
866913005688	arginine finger; other site
866913005689	hypothetical protein; Provisional; Region: PRK11032
866913005690	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
866913005691	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913005692	Sel1-like repeats; Region: SEL1; smart00671
866913005693	Sel1-like repeats; Region: SEL1; smart00671
866913005694	Sel1-like repeats; Region: SEL1; smart00671
866913005695	Sel1-like repeats; Region: SEL1; smart00671
866913005696	Sel1-like repeats; Region: SEL1; smart00671
866913005697	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
866913005698	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
866913005699	HSP70 interaction site [polypeptide binding]; other site
866913005700	DnaJ domain; Region: DnaJ; pfam00226
866913005701	HSP70 interaction site [polypeptide binding]; other site
866913005702	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
866913005703	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
866913005704	nucleotide binding site [chemical binding]; other site
866913005705	putative NEF/HSP70 interaction site [polypeptide binding]; other site
866913005706	SBD interface [polypeptide binding]; other site
866913005707	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
866913005708	active site
866913005709	tetramer interface [polypeptide binding]; other site
866913005710	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866913005711	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866913005712	Walker A/P-loop; other site
866913005713	ATP binding site [chemical binding]; other site
866913005714	Q-loop/lid; other site
866913005715	ABC transporter signature motif; other site
866913005716	Walker B; other site
866913005717	D-loop; other site
866913005718	H-loop/switch region; other site
866913005719	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913005720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913005721	dimer interface [polypeptide binding]; other site
866913005722	conserved gate region; other site
866913005723	putative PBP binding loops; other site
866913005724	ABC-ATPase subunit interface; other site
866913005725	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913005726	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913005727	dimer interface [polypeptide binding]; other site
866913005728	conserved gate region; other site
866913005729	putative PBP binding loops; other site
866913005730	ABC-ATPase subunit interface; other site
866913005731	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
866913005732	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913005733	substrate binding pocket [chemical binding]; other site
866913005734	membrane-bound complex binding site; other site
866913005735	hinge residues; other site
866913005736	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
866913005737	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
866913005738	putative active site [active]
866913005739	catalytic triad [active]
866913005740	putative dimer interface [polypeptide binding]; other site
866913005741	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
866913005742	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866913005743	Transporter associated domain; Region: CorC_HlyC; smart01091
866913005744	metal-binding heat shock protein; Provisional; Region: PRK00016
866913005745	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
866913005746	PhoH-like protein; Region: PhoH; pfam02562
866913005747	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
866913005748	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
866913005749	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913005750	FeS/SAM binding site; other site
866913005751	TRAM domain; Region: TRAM; pfam01938
866913005752	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
866913005753	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866913005754	asparagine synthetase B; Provisional; Region: asnB; PRK09431
866913005755	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
866913005756	active site
866913005757	dimer interface [polypeptide binding]; other site
866913005758	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
866913005759	Ligand Binding Site [chemical binding]; other site
866913005760	Molecular Tunnel; other site
866913005761	UMP phosphatase; Provisional; Region: PRK10444
866913005762	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913005763	active site
866913005764	motif I; other site
866913005765	motif II; other site
866913005766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913005767	MarR family; Region: MarR; pfam01047
866913005768	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866913005769	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913005770	nucleotide binding site [chemical binding]; other site
866913005771	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
866913005772	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
866913005773	active site
866913005774	dimer interface [polypeptide binding]; other site
866913005775	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
866913005776	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
866913005777	active site
866913005778	trimer interface [polypeptide binding]; other site
866913005779	allosteric site; other site
866913005780	active site lid [active]
866913005781	hexamer (dimer of trimers) interface [polypeptide binding]; other site
866913005782	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
866913005783	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866913005784	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866913005785	active site turn [active]
866913005786	phosphorylation site [posttranslational modification]
866913005787	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
866913005788	HPr interaction site; other site
866913005789	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866913005790	active site
866913005791	phosphorylation site [posttranslational modification]
866913005792	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
866913005793	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866913005794	active site
866913005795	HIGH motif; other site
866913005796	nucleotide binding site [chemical binding]; other site
866913005797	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
866913005798	KMSKS motif; other site
866913005799	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
866913005800	outer membrane porin, OprD family; Region: OprD; pfam03573
866913005801	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
866913005802	YbfN-like lipoprotein; Region: YbfN; pfam13982
866913005803	citrate-proton symporter; Provisional; Region: PRK15075
866913005804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913005805	putative substrate translocation pore; other site
866913005806	tricarballylate utilization protein B; Provisional; Region: PRK15033
866913005807	tricarballylate dehydrogenase; Validated; Region: PRK08274
866913005808	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913005809	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913005810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913005811	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
866913005812	putative dimerization interface [polypeptide binding]; other site
866913005813	ferric uptake regulator; Provisional; Region: fur; PRK09462
866913005814	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866913005815	metal binding site 2 [ion binding]; metal-binding site
866913005816	putative DNA binding helix; other site
866913005817	metal binding site 1 [ion binding]; metal-binding site
866913005818	dimer interface [polypeptide binding]; other site
866913005819	structural Zn2+ binding site [ion binding]; other site
866913005820	flavodoxin FldA; Validated; Region: PRK09267
866913005821	LexA regulated protein; Provisional; Region: PRK11675
866913005822	acyl-CoA esterase; Provisional; Region: PRK10673
866913005823	PGAP1-like protein; Region: PGAP1; pfam07819
866913005824	replication initiation regulator SeqA; Provisional; Region: PRK11187
866913005825	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
866913005826	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
866913005827	active site
866913005828	substrate binding site [chemical binding]; other site
866913005829	metal binding site [ion binding]; metal-binding site
866913005830	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
866913005831	putrescine transporter; Provisional; Region: potE; PRK10655
866913005832	ornithine decarboxylase; Provisional; Region: PRK13578
866913005833	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
866913005834	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
866913005835	homodimer interface [polypeptide binding]; other site
866913005836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913005837	catalytic residue [active]
866913005838	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
866913005839	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
866913005840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913005841	active site
866913005842	phosphorylation site [posttranslational modification]
866913005843	intermolecular recognition site; other site
866913005844	dimerization interface [polypeptide binding]; other site
866913005845	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913005846	DNA binding site [nucleotide binding]
866913005847	sensor protein KdpD; Provisional; Region: PRK10490
866913005848	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
866913005849	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
866913005850	Ligand Binding Site [chemical binding]; other site
866913005851	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
866913005852	GAF domain; Region: GAF_3; pfam13492
866913005853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913005854	dimer interface [polypeptide binding]; other site
866913005855	phosphorylation site [posttranslational modification]
866913005856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913005857	ATP binding site [chemical binding]; other site
866913005858	Mg2+ binding site [ion binding]; other site
866913005859	G-X-G motif; other site
866913005860	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
866913005861	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
866913005862	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866913005863	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
866913005864	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
866913005865	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
866913005866	DNA photolyase; Region: DNA_photolyase; pfam00875
866913005867	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
866913005868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913005869	putative substrate translocation pore; other site
866913005870	POT family; Region: PTR2; pfam00854
866913005871	Uncharacterized conserved protein [Function unknown]; Region: COG0327
866913005872	metal-binding protein; Provisional; Region: PRK10799
866913005873	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
866913005874	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
866913005875	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
866913005876	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
866913005877	putative active site [active]
866913005878	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866913005879	active site
866913005880	DNA binding site [nucleotide binding]
866913005881	Int/Topo IB signature motif; other site
866913005882	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
866913005883	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866913005884	UDP-galactopyranose mutase; Region: GLF; pfam03275
866913005885	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
866913005886	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913005887	active site
866913005888	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
866913005889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866913005890	putative ADP-binding pocket [chemical binding]; other site
866913005891	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
866913005892	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866913005893	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
866913005894	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
866913005895	Walker A/P-loop; other site
866913005896	ATP binding site [chemical binding]; other site
866913005897	Q-loop/lid; other site
866913005898	ABC transporter signature motif; other site
866913005899	Walker B; other site
866913005900	D-loop; other site
866913005901	H-loop/switch region; other site
866913005902	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
866913005903	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913005904	active site
866913005905	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913005906	active site
866913005907	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
866913005908	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
866913005909	endonuclease VIII; Provisional; Region: PRK10445
866913005910	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
866913005911	DNA binding site [nucleotide binding]
866913005912	catalytic residue [active]
866913005913	putative catalytic residues [active]
866913005914	H2TH interface [polypeptide binding]; other site
866913005915	intercalation triad [nucleotide binding]; other site
866913005916	substrate specificity determining residue; other site
866913005917	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
866913005918	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
866913005919	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
866913005920	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
866913005921	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
866913005922	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
866913005923	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
866913005924	dimer interface [polypeptide binding]; other site
866913005925	active site
866913005926	citrylCoA binding site [chemical binding]; other site
866913005927	NADH binding [chemical binding]; other site
866913005928	cationic pore residues; other site
866913005929	oxalacetate/citrate binding site [chemical binding]; other site
866913005930	coenzyme A binding site [chemical binding]; other site
866913005931	catalytic triad [active]
866913005932	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
866913005933	Iron-sulfur protein interface; other site
866913005934	proximal quinone binding site [chemical binding]; other site
866913005935	SdhD (CybS) interface [polypeptide binding]; other site
866913005936	proximal heme binding site [chemical binding]; other site
866913005937	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
866913005938	SdhC subunit interface [polypeptide binding]; other site
866913005939	proximal heme binding site [chemical binding]; other site
866913005940	cardiolipin binding site; other site
866913005941	Iron-sulfur protein interface; other site
866913005942	proximal quinone binding site [chemical binding]; other site
866913005943	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
866913005944	L-aspartate oxidase; Provisional; Region: PRK06175
866913005945	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
866913005946	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
866913005947	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
866913005948	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
866913005949	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
866913005950	TPP-binding site [chemical binding]; other site
866913005951	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
866913005952	dimer interface [polypeptide binding]; other site
866913005953	PYR/PP interface [polypeptide binding]; other site
866913005954	TPP binding site [chemical binding]; other site
866913005955	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
866913005956	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866913005957	E3 interaction surface; other site
866913005958	lipoyl attachment site [posttranslational modification]; other site
866913005959	e3 binding domain; Region: E3_binding; pfam02817
866913005960	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866913005961	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
866913005962	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
866913005963	CoA-ligase; Region: Ligase_CoA; pfam00549
866913005964	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
866913005965	CoA binding domain; Region: CoA_binding; smart00881
866913005966	CoA-ligase; Region: Ligase_CoA; pfam00549
866913005967	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
866913005968	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
866913005969	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
866913005970	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
866913005971	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
866913005972	hypothetical protein; Provisional; Region: PRK10588
866913005973	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
866913005974	active site
866913005975	colicin uptake protein TolQ; Provisional; Region: PRK10801
866913005976	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
866913005977	colicin uptake protein TolR; Provisional; Region: PRK11024
866913005978	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
866913005979	TolA C-terminal; Region: TolA; pfam06519
866913005980	translocation protein TolB; Provisional; Region: tolB; PRK03629
866913005981	TolB amino-terminal domain; Region: TolB_N; pfam04052
866913005982	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
866913005983	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
866913005984	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
866913005985	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
866913005986	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
866913005987	ligand binding site [chemical binding]; other site
866913005988	tol-pal system protein YbgF; Provisional; Region: PRK10803
866913005989	Tetratricopeptide repeat; Region: TPR_6; pfam13174
866913005990	Tetratricopeptide repeat; Region: TPR_6; pfam13174
866913005991	quinolinate synthetase; Provisional; Region: PRK09375
866913005992	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
866913005993	zinc transporter ZitB; Provisional; Region: PRK03557
866913005994	YbgS-like protein; Region: YbgS; pfam13985
866913005995	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
866913005996	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
866913005997	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
866913005998	fumarate hydratase; Provisional; Region: PRK06246
866913005999	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913006000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913006001	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866913006002	dimerization interface [polypeptide binding]; other site
866913006003	cell density-dependent motility repressor; Provisional; Region: PRK10082
866913006004	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913006005	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866913006006	dimerization interface [polypeptide binding]; other site
866913006007	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
866913006008	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
866913006009	transmembrane helices; other site
866913006010	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
866913006011	oxaloacetate decarboxylase; Provisional; Region: PRK14040
866913006012	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
866913006013	active site
866913006014	catalytic residues [active]
866913006015	metal binding site [ion binding]; metal-binding site
866913006016	homodimer binding site [polypeptide binding]; other site
866913006017	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866913006018	carboxyltransferase (CT) interaction site; other site
866913006019	biotinylation site [posttranslational modification]; other site
866913006020	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
866913006021	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
866913006022	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866913006023	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913006024	dimer interface [polypeptide binding]; other site
866913006025	putative PBP binding regions; other site
866913006026	ABC-ATPase subunit  interface; other site
866913006027	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
866913006028	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866913006029	Walker A/P-loop; other site
866913006030	ATP binding site [chemical binding]; other site
866913006031	Q-loop/lid; other site
866913006032	ABC transporter signature motif; other site
866913006033	Walker B; other site
866913006034	D-loop; other site
866913006035	H-loop/switch region; other site
866913006036	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866913006037	catalytic core [active]
866913006038	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866913006039	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
866913006040	active site
866913006041	catalytic residues [active]
866913006042	galactokinase; Provisional; Region: PRK05101
866913006043	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
866913006044	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866913006045	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866913006046	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
866913006047	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
866913006048	dimer interface [polypeptide binding]; other site
866913006049	active site
866913006050	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
866913006051	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
866913006052	NAD binding site [chemical binding]; other site
866913006053	homodimer interface [polypeptide binding]; other site
866913006054	active site
866913006055	substrate binding site [chemical binding]; other site
866913006056	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
866913006057	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
866913006058	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006059	Walker A/P-loop; other site
866913006060	ATP binding site [chemical binding]; other site
866913006061	Q-loop/lid; other site
866913006062	ABC transporter signature motif; other site
866913006063	Walker B; other site
866913006064	D-loop; other site
866913006065	H-loop/switch region; other site
866913006066	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006067	Walker A/P-loop; other site
866913006068	ATP binding site [chemical binding]; other site
866913006069	Q-loop/lid; other site
866913006070	ABC transporter signature motif; other site
866913006071	Walker B; other site
866913006072	D-loop; other site
866913006073	H-loop/switch region; other site
866913006074	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
866913006075	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
866913006076	molybdenum-pterin binding domain; Region: Mop; TIGR00638
866913006077	TOBE domain; Region: TOBE; pfam03459
866913006078	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
866913006079	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
866913006080	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913006081	substrate binding pocket [chemical binding]; other site
866913006082	membrane-bound complex binding site; other site
866913006083	hinge residues; other site
866913006084	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
866913006085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006086	dimer interface [polypeptide binding]; other site
866913006087	conserved gate region; other site
866913006088	putative PBP binding loops; other site
866913006089	ABC-ATPase subunit interface; other site
866913006090	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
866913006091	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006092	Walker A/P-loop; other site
866913006093	ATP binding site [chemical binding]; other site
866913006094	Q-loop/lid; other site
866913006095	ABC transporter signature motif; other site
866913006096	Walker B; other site
866913006097	D-loop; other site
866913006098	H-loop/switch region; other site
866913006099	molybdenum-pterin binding domain; Region: Mop; TIGR00638
866913006100	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
866913006101	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913006102	active site
866913006103	motif I; other site
866913006104	motif II; other site
866913006105	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913006106	6-phosphogluconolactonase; Provisional; Region: PRK11028
866913006107	acyl-CoA thioesterase; Provisional; Region: PRK10531
866913006108	putative pectinesterase; Region: PLN02432; cl01911
866913006109	imidazolonepropionase; Validated; Region: PRK09356
866913006110	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
866913006111	active site
866913006112	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
866913006113	putative active site [active]
866913006114	putative metal binding site [ion binding]; other site
866913006115	histidine utilization repressor; Provisional; Region: PRK14999
866913006116	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913006117	DNA-binding site [nucleotide binding]; DNA binding site
866913006118	UTRA domain; Region: UTRA; pfam07702
866913006119	urocanate hydratase; Provisional; Region: PRK05414
866913006120	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
866913006121	active sites [active]
866913006122	tetramer interface [polypeptide binding]; other site
866913006123	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
866913006124	substrate binding site [chemical binding]; other site
866913006125	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
866913006126	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866913006127	inhibitor-cofactor binding pocket; inhibition site
866913006128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913006129	catalytic residue [active]
866913006130	biotin synthase; Provisional; Region: PRK15108
866913006131	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913006132	FeS/SAM binding site; other site
866913006133	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
866913006134	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
866913006135	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
866913006136	substrate-cofactor binding pocket; other site
866913006137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913006138	catalytic residue [active]
866913006139	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
866913006140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913006141	S-adenosylmethionine binding site [chemical binding]; other site
866913006142	AAA domain; Region: AAA_26; pfam13500
866913006143	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
866913006144	excinuclease ABC subunit B; Provisional; Region: PRK05298
866913006145	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913006146	ATP binding site [chemical binding]; other site
866913006147	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913006148	nucleotide binding region [chemical binding]; other site
866913006149	ATP-binding site [chemical binding]; other site
866913006150	Ultra-violet resistance protein B; Region: UvrB; pfam12344
866913006151	UvrB/uvrC motif; Region: UVR; pfam02151
866913006152	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
866913006153	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
866913006154	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
866913006155	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
866913006156	Leucine-rich repeats; other site
866913006157	Substrate binding site [chemical binding]; other site
866913006158	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
866913006159	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
866913006160	putative substrate binding pocket [chemical binding]; other site
866913006161	dimer interface [polypeptide binding]; other site
866913006162	phosphate binding site [ion binding]; other site
866913006163	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
866913006164	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913006165	FeS/SAM binding site; other site
866913006166	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
866913006167	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
866913006168	MPT binding site; other site
866913006169	trimer interface [polypeptide binding]; other site
866913006170	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
866913006171	trimer interface [polypeptide binding]; other site
866913006172	dimer interface [polypeptide binding]; other site
866913006173	putative active site [active]
866913006174	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
866913006175	MoaE interaction surface [polypeptide binding]; other site
866913006176	MoeB interaction surface [polypeptide binding]; other site
866913006177	thiocarboxylated glycine; other site
866913006178	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
866913006179	MoaE homodimer interface [polypeptide binding]; other site
866913006180	MoaD interaction [polypeptide binding]; other site
866913006181	active site residues [active]
866913006182	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
866913006183	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
866913006184	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
866913006185	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
866913006186	Predicted integral membrane protein [Function unknown]; Region: COG0392
866913006187	cardiolipin synthase 2; Provisional; Region: PRK11263
866913006188	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
866913006189	putative active site [active]
866913006190	catalytic site [active]
866913006191	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
866913006192	putative active site [active]
866913006193	catalytic site [active]
866913006194	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
866913006195	putative catalytic site [active]
866913006196	putative metal binding site [ion binding]; other site
866913006197	putative phosphate binding site [ion binding]; other site
866913006198	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
866913006199	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866913006200	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866913006201	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866913006202	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
866913006203	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866913006204	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866913006205	Walker A/P-loop; other site
866913006206	ATP binding site [chemical binding]; other site
866913006207	Q-loop/lid; other site
866913006208	ABC transporter signature motif; other site
866913006209	Walker B; other site
866913006210	D-loop; other site
866913006211	H-loop/switch region; other site
866913006212	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
866913006213	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866913006214	Walker A/P-loop; other site
866913006215	ATP binding site [chemical binding]; other site
866913006216	Q-loop/lid; other site
866913006217	ABC transporter signature motif; other site
866913006218	Walker B; other site
866913006219	D-loop; other site
866913006220	H-loop/switch region; other site
866913006221	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
866913006222	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866913006223	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913006224	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
866913006225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913006226	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
866913006227	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
866913006228	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866913006229	ATP binding site [chemical binding]; other site
866913006230	Mg++ binding site [ion binding]; other site
866913006231	motif III; other site
866913006232	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913006233	nucleotide binding region [chemical binding]; other site
866913006234	ATP-binding site [chemical binding]; other site
866913006235	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
866913006236	DEAD_2; Region: DEAD_2; pfam06733
866913006237	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
866913006238	glycosyl transferase family protein; Provisional; Region: PRK08136
866913006239	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
866913006240	hypothetical protein; Provisional; Region: PRK10259
866913006241	hypothetical protein; Provisional; Region: PRK11019
866913006242	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
866913006243	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
866913006244	putative mechanosensitive channel protein; Provisional; Region: PRK11465
866913006245	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913006246	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
866913006247	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866913006248	Walker A/P-loop; other site
866913006249	ATP binding site [chemical binding]; other site
866913006250	Q-loop/lid; other site
866913006251	ABC transporter signature motif; other site
866913006252	Walker B; other site
866913006253	D-loop; other site
866913006254	H-loop/switch region; other site
866913006255	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913006256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006257	dimer interface [polypeptide binding]; other site
866913006258	conserved gate region; other site
866913006259	putative PBP binding loops; other site
866913006260	ABC-ATPase subunit interface; other site
866913006261	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
866913006262	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913006263	substrate binding pocket [chemical binding]; other site
866913006264	membrane-bound complex binding site; other site
866913006265	hinge residues; other site
866913006266	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
866913006267	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
866913006268	dimerization interface [polypeptide binding]; other site
866913006269	DPS ferroxidase diiron center [ion binding]; other site
866913006270	ion pore; other site
866913006271	threonine and homoserine efflux system; Provisional; Region: PRK10532
866913006272	EamA-like transporter family; Region: EamA; pfam00892
866913006273	outer membrane protein X; Provisional; Region: ompX; PRK09408
866913006274	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
866913006275	Sulfatase; Region: Sulfatase; pfam00884
866913006276	manganese transport regulator MntR; Provisional; Region: PRK11050
866913006277	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
866913006278	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
866913006279	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
866913006280	transmembrane helices; other site
866913006281	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
866913006282	L,D-transpeptidase; Provisional; Region: PRK10260
866913006283	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866913006284	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
866913006285	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913006286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006287	Walker A/P-loop; other site
866913006288	ATP binding site [chemical binding]; other site
866913006289	ABC transporter signature motif; other site
866913006290	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913006291	Walker B; other site
866913006292	ABC transporter; Region: ABC_tran_2; pfam12848
866913006293	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913006294	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
866913006295	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913006296	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
866913006297	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
866913006298	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913006299	active site
866913006300	motif I; other site
866913006301	motif II; other site
866913006302	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913006303	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
866913006304	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
866913006305	dimer interface [polypeptide binding]; other site
866913006306	active site
866913006307	glycine loop; other site
866913006308	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
866913006309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913006310	FeS/SAM binding site; other site
866913006311	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
866913006312	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
866913006313	ATP binding site [chemical binding]; other site
866913006314	substrate interface [chemical binding]; other site
866913006315	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
866913006316	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
866913006317	dimer interface [polypeptide binding]; other site
866913006318	putative functional site; other site
866913006319	putative MPT binding site; other site
866913006320	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
866913006321	catalytic nucleophile [active]
866913006322	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
866913006323	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913006324	Walker A/P-loop; other site
866913006325	ATP binding site [chemical binding]; other site
866913006326	Q-loop/lid; other site
866913006327	ABC transporter signature motif; other site
866913006328	Walker B; other site
866913006329	D-loop; other site
866913006330	H-loop/switch region; other site
866913006331	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866913006332	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913006333	Walker A/P-loop; other site
866913006334	ATP binding site [chemical binding]; other site
866913006335	Q-loop/lid; other site
866913006336	ABC transporter signature motif; other site
866913006337	Walker B; other site
866913006338	D-loop; other site
866913006339	H-loop/switch region; other site
866913006340	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
866913006341	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
866913006342	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
866913006343	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
866913006344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006345	dimer interface [polypeptide binding]; other site
866913006346	conserved gate region; other site
866913006347	putative PBP binding loops; other site
866913006348	ABC-ATPase subunit interface; other site
866913006349	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
866913006350	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
866913006351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006352	dimer interface [polypeptide binding]; other site
866913006353	conserved gate region; other site
866913006354	putative PBP binding loops; other site
866913006355	ABC-ATPase subunit interface; other site
866913006356	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
866913006357	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
866913006358	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913006359	FeS/SAM binding site; other site
866913006360	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
866913006361	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
866913006362	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
866913006363	Ligand binding site [chemical binding]; other site
866913006364	Electron transfer flavoprotein domain; Region: ETF; pfam01012
866913006365	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
866913006366	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
866913006367	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
866913006368	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866913006369	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866913006370	active site
866913006371	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
866913006372	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913006373	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
866913006374	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
866913006375	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913006376	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913006377	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
866913006378	putative dimerization interface [polypeptide binding]; other site
866913006379	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
866913006380	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
866913006381	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
866913006382	putative C-terminal domain interface [polypeptide binding]; other site
866913006383	putative GSH binding site (G-site) [chemical binding]; other site
866913006384	putative dimer interface [polypeptide binding]; other site
866913006385	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
866913006386	putative N-terminal domain interface [polypeptide binding]; other site
866913006387	putative dimer interface [polypeptide binding]; other site
866913006388	putative substrate binding pocket (H-site) [chemical binding]; other site
866913006389	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
866913006390	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866913006391	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
866913006392	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
866913006393	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866913006394	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913006395	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866913006396	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
866913006397	active site
866913006398	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
866913006399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913006400	putative substrate translocation pore; other site
866913006401	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
866913006402	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913006403	active site
866913006404	motif I; other site
866913006405	motif II; other site
866913006406	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913006407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913006408	putative substrate translocation pore; other site
866913006409	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913006410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
866913006411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913006412	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
866913006413	putative transporter; Provisional; Region: PRK04972
866913006414	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
866913006415	TrkA-C domain; Region: TrkA_C; pfam02080
866913006416	TrkA-C domain; Region: TrkA_C; pfam02080
866913006417	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
866913006418	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
866913006419	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
866913006420	GSH binding site [chemical binding]; other site
866913006421	catalytic residues [active]
866913006422	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
866913006423	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
866913006424	dimer interface [polypeptide binding]; other site
866913006425	FMN binding site [chemical binding]; other site
866913006426	NADPH bind site [chemical binding]; other site
866913006427	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
866913006428	RimK-like ATP-grasp domain; Region: RimK; pfam08443
866913006429	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
866913006430	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
866913006431	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866913006432	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
866913006433	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006434	Walker A/P-loop; other site
866913006435	ATP binding site [chemical binding]; other site
866913006436	Q-loop/lid; other site
866913006437	ABC transporter signature motif; other site
866913006438	Walker B; other site
866913006439	D-loop; other site
866913006440	H-loop/switch region; other site
866913006441	TOBE domain; Region: TOBE_2; pfam08402
866913006442	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
866913006443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006444	dimer interface [polypeptide binding]; other site
866913006445	conserved gate region; other site
866913006446	putative PBP binding loops; other site
866913006447	ABC-ATPase subunit interface; other site
866913006448	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
866913006449	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006450	dimer interface [polypeptide binding]; other site
866913006451	conserved gate region; other site
866913006452	putative PBP binding loops; other site
866913006453	ABC-ATPase subunit interface; other site
866913006454	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
866913006455	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
866913006456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913006457	S-adenosylmethionine binding site [chemical binding]; other site
866913006458	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
866913006459	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
866913006460	active site
866913006461	P-loop; other site
866913006462	phosphorylation site [posttranslational modification]
866913006463	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
866913006464	Sulfatase; Region: Sulfatase; cl17466
866913006465	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
866913006466	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913006467	substrate binding pocket [chemical binding]; other site
866913006468	membrane-bound complex binding site; other site
866913006469	hinge residues; other site
866913006470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006471	dimer interface [polypeptide binding]; other site
866913006472	conserved gate region; other site
866913006473	putative PBP binding loops; other site
866913006474	ABC-ATPase subunit interface; other site
866913006475	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913006476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913006477	dimer interface [polypeptide binding]; other site
866913006478	conserved gate region; other site
866913006479	putative PBP binding loops; other site
866913006480	ABC-ATPase subunit interface; other site
866913006481	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
866913006482	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913006483	substrate binding pocket [chemical binding]; other site
866913006484	membrane-bound complex binding site; other site
866913006485	hinge residues; other site
866913006486	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
866913006487	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006488	Walker A/P-loop; other site
866913006489	ATP binding site [chemical binding]; other site
866913006490	Q-loop/lid; other site
866913006491	ABC transporter signature motif; other site
866913006492	Walker B; other site
866913006493	D-loop; other site
866913006494	H-loop/switch region; other site
866913006495	putative lipoprotein; Provisional; Region: PRK10533
866913006496	hypothetical protein; Provisional; Region: PRK02877
866913006497	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
866913006498	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
866913006499	amidase catalytic site [active]
866913006500	Zn binding residues [ion binding]; other site
866913006501	substrate binding site [chemical binding]; other site
866913006502	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866913006503	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866913006504	NAD(P) binding site [chemical binding]; other site
866913006505	active site
866913006506	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
866913006507	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
866913006508	putative NAD(P) binding site [chemical binding]; other site
866913006509	putative active site [active]
866913006510	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
866913006511	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
866913006512	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
866913006513	tetramer interface [polypeptide binding]; other site
866913006514	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913006515	catalytic residue [active]
866913006516	pyruvate dehydrogenase; Provisional; Region: PRK09124
866913006517	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
866913006518	PYR/PP interface [polypeptide binding]; other site
866913006519	dimer interface [polypeptide binding]; other site
866913006520	tetramer interface [polypeptide binding]; other site
866913006521	TPP binding site [chemical binding]; other site
866913006522	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866913006523	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
866913006524	TPP-binding site [chemical binding]; other site
866913006525	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
866913006526	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
866913006527	FAD binding pocket [chemical binding]; other site
866913006528	FAD binding motif [chemical binding]; other site
866913006529	phosphate binding motif [ion binding]; other site
866913006530	beta-alpha-beta structure motif; other site
866913006531	NAD binding pocket [chemical binding]; other site
866913006532	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
866913006533	catalytic loop [active]
866913006534	iron binding site [ion binding]; other site
866913006535	hybrid cluster protein; Provisional; Region: PRK05290
866913006536	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866913006537	ACS interaction site; other site
866913006538	CODH interaction site; other site
866913006539	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
866913006540	hybrid metal cluster; other site
866913006541	Predicted membrane protein [Function unknown]; Region: COG2431
866913006542	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
866913006543	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
866913006544	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
866913006545	putative active site [active]
866913006546	putative metal-binding site [ion binding]; other site
866913006547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
866913006548	macrolide transporter subunit MacA; Provisional; Region: PRK11578
866913006549	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913006550	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913006551	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
866913006552	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866913006553	Walker A/P-loop; other site
866913006554	ATP binding site [chemical binding]; other site
866913006555	Q-loop/lid; other site
866913006556	ABC transporter signature motif; other site
866913006557	Walker B; other site
866913006558	D-loop; other site
866913006559	H-loop/switch region; other site
866913006560	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866913006561	FtsX-like permease family; Region: FtsX; pfam02687
866913006562	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866913006563	DNA-binding site [nucleotide binding]; DNA binding site
866913006564	RNA-binding motif; other site
866913006565	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
866913006566	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
866913006567	Clp amino terminal domain; Region: Clp_N; pfam02861
866913006568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913006569	Walker A motif; other site
866913006570	ATP binding site [chemical binding]; other site
866913006571	Walker B motif; other site
866913006572	arginine finger; other site
866913006573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913006574	Walker A motif; other site
866913006575	ATP binding site [chemical binding]; other site
866913006576	Walker B motif; other site
866913006577	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866913006578	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913006579	Integrase core domain; Region: rve; pfam00665
866913006580	Integrase core domain; Region: rve_3; pfam13683
866913006581	Helix-turn-helix domain; Region: HTH_28; pfam13518
866913006582	Isochorismatase family; Region: Isochorismatase; pfam00857
866913006583	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
866913006584	catalytic triad [active]
866913006585	dimer interface [polypeptide binding]; other site
866913006586	conserved cis-peptide bond; other site
866913006587	Pirin-related protein [General function prediction only]; Region: COG1741
866913006588	Pirin; Region: Pirin; pfam02678
866913006589	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
866913006590	LysR family transcriptional regulator; Provisional; Region: PRK14997
866913006591	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913006592	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
866913006593	putative effector binding pocket; other site
866913006594	putative dimerization interface [polypeptide binding]; other site
866913006595	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
866913006596	rRNA binding site [nucleotide binding]; other site
866913006597	predicted 30S ribosome binding site; other site
866913006598	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
866913006599	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
866913006600	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913006601	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006602	Walker A/P-loop; other site
866913006603	ATP binding site [chemical binding]; other site
866913006604	Q-loop/lid; other site
866913006605	ABC transporter signature motif; other site
866913006606	Walker B; other site
866913006607	D-loop; other site
866913006608	H-loop/switch region; other site
866913006609	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
866913006610	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913006611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006612	Walker A/P-loop; other site
866913006613	ATP binding site [chemical binding]; other site
866913006614	Q-loop/lid; other site
866913006615	ABC transporter signature motif; other site
866913006616	Walker B; other site
866913006617	D-loop; other site
866913006618	H-loop/switch region; other site
866913006619	thioredoxin reductase; Provisional; Region: PRK10262
866913006620	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913006621	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913006622	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
866913006623	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913006624	putative DNA binding site [nucleotide binding]; other site
866913006625	putative Zn2+ binding site [ion binding]; other site
866913006626	AsnC family; Region: AsnC_trans_reg; pfam01037
866913006627	DNA translocase FtsK; Provisional; Region: PRK10263
866913006628	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
866913006629	DNA translocase FtsK; Provisional; Region: PRK10263
866913006630	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
866913006631	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
866913006632	periplasmic chaperone LolA; Region: lolA; TIGR00547
866913006633	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
866913006634	recombination factor protein RarA; Reviewed; Region: PRK13342
866913006635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913006636	Walker A motif; other site
866913006637	ATP binding site [chemical binding]; other site
866913006638	Walker B motif; other site
866913006639	arginine finger; other site
866913006640	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
866913006641	seryl-tRNA synthetase; Provisional; Region: PRK05431
866913006642	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
866913006643	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
866913006644	dimer interface [polypeptide binding]; other site
866913006645	active site
866913006646	motif 1; other site
866913006647	motif 2; other site
866913006648	motif 3; other site
866913006649	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
866913006650	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
866913006651	putative [Fe4-S4] binding site [ion binding]; other site
866913006652	putative molybdopterin cofactor binding site [chemical binding]; other site
866913006653	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
866913006654	putative molybdopterin cofactor binding site; other site
866913006655	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
866913006656	4Fe-4S binding domain; Region: Fer4; pfam00037
866913006657	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
866913006658	putative MFS family transporter protein; Provisional; Region: PRK03633
866913006659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913006660	putative substrate translocation pore; other site
866913006661	inner membrane transporter YjeM; Provisional; Region: PRK15238
866913006662	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
866913006663	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913006664	FeS/SAM binding site; other site
866913006665	integrase; Provisional; Region: int; PHA02601
866913006666	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
866913006667	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
866913006668	Pyruvate formate lyase 1; Region: PFL1; cd01678
866913006669	coenzyme A binding site [chemical binding]; other site
866913006670	active site
866913006671	catalytic residues [active]
866913006672	glycine loop; other site
866913006673	formate transporter; Provisional; Region: PRK10805
866913006674	uncharacterized domain; Region: TIGR00702
866913006675	YcaO-like family; Region: YcaO; pfam02624
866913006676	Predicted membrane protein [Function unknown]; Region: COG2323
866913006677	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
866913006678	homodimer interface [polypeptide binding]; other site
866913006679	substrate-cofactor binding pocket; other site
866913006680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913006681	catalytic residue [active]
866913006682	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
866913006683	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
866913006684	hinge; other site
866913006685	active site
866913006686	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
866913006687	cytidylate kinase; Provisional; Region: cmk; PRK00023
866913006688	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
866913006689	CMP-binding site; other site
866913006690	The sites determining sugar specificity; other site
866913006691	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
866913006692	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
866913006693	RNA binding site [nucleotide binding]; other site
866913006694	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
866913006695	RNA binding site [nucleotide binding]; other site
866913006696	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
866913006697	RNA binding site [nucleotide binding]; other site
866913006698	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
866913006699	RNA binding site [nucleotide binding]; other site
866913006700	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
866913006701	RNA binding site [nucleotide binding]; other site
866913006702	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
866913006703	IHF dimer interface [polypeptide binding]; other site
866913006704	IHF - DNA interface [nucleotide binding]; other site
866913006705	ComEC family competence protein; Provisional; Region: PRK11539
866913006706	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
866913006707	Competence protein; Region: Competence; pfam03772
866913006708	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
866913006709	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
866913006710	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913006711	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
866913006712	Walker A/P-loop; other site
866913006713	ATP binding site [chemical binding]; other site
866913006714	Q-loop/lid; other site
866913006715	ABC transporter signature motif; other site
866913006716	Walker B; other site
866913006717	D-loop; other site
866913006718	H-loop/switch region; other site
866913006719	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
866913006720	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
866913006721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
866913006722	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
866913006723	hypothetical protein; Provisional; Region: PRK11827
866913006724	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
866913006725	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
866913006726	Ligand binding site; other site
866913006727	oligomer interface; other site
866913006728	hypothetical protein; Provisional; Region: PRK10593
866913006729	Uncharacterized conserved protein [Function unknown]; Region: COG1434
866913006730	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866913006731	putative active site [active]
866913006732	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
866913006733	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913006734	S-adenosylmethionine binding site [chemical binding]; other site
866913006735	condesin subunit F; Provisional; Region: PRK05260
866913006736	condesin subunit E; Provisional; Region: PRK05256
866913006737	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
866913006738	P-loop containing region of AAA domain; Region: AAA_29; cl17516
866913006739	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
866913006740	murein L,D-transpeptidase; Provisional; Region: PRK10594
866913006741	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866913006742	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866913006743	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866913006744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
866913006745	Peptidase M15; Region: Peptidase_M15_3; cl01194
866913006746	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
866913006747	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
866913006748	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913006749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913006750	homodimer interface [polypeptide binding]; other site
866913006751	catalytic residue [active]
866913006752	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913006753	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
866913006754	trimer interface [polypeptide binding]; other site
866913006755	eyelet of channel; other site
866913006756	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
866913006757	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
866913006758	putative dimer interface [polypeptide binding]; other site
866913006759	putative anticodon binding site; other site
866913006760	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
866913006761	homodimer interface [polypeptide binding]; other site
866913006762	motif 1; other site
866913006763	motif 2; other site
866913006764	active site
866913006765	motif 3; other site
866913006766	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
866913006767	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913006768	putative DNA binding site [nucleotide binding]; other site
866913006769	putative Zn2+ binding site [ion binding]; other site
866913006770	AsnC family; Region: AsnC_trans_reg; pfam01037
866913006771	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
866913006772	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
866913006773	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913006774	catalytic residue [active]
866913006775	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
866913006776	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
866913006777	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
866913006778	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
866913006779	active site
866913006780	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
866913006781	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
866913006782	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
866913006783	Int/Topo IB signature motif; other site
866913006784	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
866913006785	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
866913006786	RecT family; Region: RecT; pfam03837
866913006787	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
866913006788	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
866913006789	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913006790	non-specific DNA binding site [nucleotide binding]; other site
866913006791	salt bridge; other site
866913006792	sequence-specific DNA binding site [nucleotide binding]; other site
866913006793	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
866913006794	DNA binding residues [nucleotide binding]
866913006795	Bacteriophage CII protein; Region: Phage_CII; pfam05269
866913006796	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
866913006797	primosomal protein DnaI; Provisional; Region: PRK02854
866913006798	putative replication protein; Provisional; Region: PRK12377
866913006799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913006800	Walker A motif; other site
866913006801	ATP binding site [chemical binding]; other site
866913006802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866913006803	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
866913006804	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
866913006805	DinI-like family; Region: DinI; pfam06183
866913006806	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
866913006807	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
866913006808	Antitermination protein; Region: Antiterm; pfam03589
866913006809	Antitermination protein; Region: Antiterm; pfam03589
866913006810	PipA protein; Region: PipA; pfam07108
866913006811	phage holin, lambda family; Region: holin_lambda; TIGR01594
866913006812	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
866913006813	catalytic residues [active]
866913006814	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
866913006815	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
866913006816	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
866913006817	Domain of unknown function (DUF1859); Region: DUF1859; pfam08948
866913006818	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
866913006819	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
866913006820	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
866913006821	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
866913006822	oligomer interface [polypeptide binding]; other site
866913006823	active site residues [active]
866913006824	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
866913006825	Uncharacterized conserved protein [Function unknown]; Region: COG5471
866913006826	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
866913006827	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
866913006828	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
866913006829	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
866913006830	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
866913006831	Minor tail protein T; Region: Phage_tail_T; cl05636
866913006832	Phage-related minor tail protein [Function unknown]; Region: COG5281
866913006833	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
866913006834	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
866913006835	Phage-related protein [Function unknown]; Region: COG4718
866913006836	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
866913006837	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
866913006838	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
866913006839	E-class dimer interface [polypeptide binding]; other site
866913006840	P-class dimer interface [polypeptide binding]; other site
866913006841	active site
866913006842	Cu2+ binding site [ion binding]; other site
866913006843	Zn2+ binding site [ion binding]; other site
866913006844	Phage-related protein [Function unknown]; Region: gp18; COG4672
866913006845	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
866913006846	MPN+ (JAMM) motif; other site
866913006847	Zinc-binding site [ion binding]; other site
866913006848	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866913006849	NlpC/P60 family; Region: NLPC_P60; cl17555
866913006850	Phage-related protein, tail component [Function unknown]; Region: COG4723
866913006851	Phage-related protein, tail component [Function unknown]; Region: COG4733
866913006852	Putative phage tail protein; Region: Phage-tail_3; pfam13550
866913006853	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
866913006854	Interdomain contacts; other site
866913006855	Cytokine receptor motif; other site
866913006856	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
866913006857	Fibronectin type III protein; Region: DUF3672; pfam12421
866913006858	Phage Tail Collar Domain; Region: Collar; pfam07484
866913006859	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913006860	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
866913006861	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
866913006862	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
866913006863	hypothetical protein; Provisional; Region: PRK09951
866913006864	DinI-like family; Region: DinI; cl11630
866913006865	aminopeptidase N; Provisional; Region: pepN; PRK14015
866913006866	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
866913006867	active site
866913006868	Zn binding site [ion binding]; other site
866913006869	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
866913006870	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
866913006871	quinone interaction residues [chemical binding]; other site
866913006872	active site
866913006873	catalytic residues [active]
866913006874	FMN binding site [chemical binding]; other site
866913006875	substrate binding site [chemical binding]; other site
866913006876	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
866913006877	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
866913006878	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
866913006879	MOSC domain; Region: MOSC; pfam03473
866913006880	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
866913006881	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
866913006882	catalytic loop [active]
866913006883	iron binding site [ion binding]; other site
866913006884	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
866913006885	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
866913006886	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
866913006887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913006888	S-adenosylmethionine binding site [chemical binding]; other site
866913006889	ABC transporter ATPase component; Reviewed; Region: PRK11147
866913006890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913006892	Walker A/P-loop; other site
866913006893	Walker A/P-loop; other site
866913006894	ATP binding site [chemical binding]; other site
866913006895	ATP binding site [chemical binding]; other site
866913006896	Q-loop/lid; other site
866913006897	Q-loop/lid; other site
866913006898	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913006899	ABC transporter signature motif; other site
866913006900	Walker B; other site
866913006901	D-loop; other site
866913006902	ABC transporter; Region: ABC_tran_2; pfam12848
866913006903	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866913006904	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
866913006905	Paraquat-inducible protein A; Region: PqiA; pfam04403
866913006906	Paraquat-inducible protein A; Region: PqiA; pfam04403
866913006907	paraquat-inducible protein B; Provisional; Region: PRK10807
866913006908	mce related protein; Region: MCE; pfam02470
866913006909	mce related protein; Region: MCE; pfam02470
866913006910	mce related protein; Region: MCE; pfam02470
866913006911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
866913006912	Protein of unknown function (DUF330); Region: DUF330; pfam03886
866913006913	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
866913006914	active site 1 [active]
866913006915	dimer interface [polypeptide binding]; other site
866913006916	active site 2 [active]
866913006917	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
866913006918	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
866913006919	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
866913006920	outer membrane protein A; Reviewed; Region: PRK10808
866913006921	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
866913006922	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
866913006923	ligand binding site [chemical binding]; other site
866913006924	cell division inhibitor SulA; Region: sula; TIGR00623
866913006925	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
866913006926	TfoX C-terminal domain; Region: TfoX_C; pfam04994
866913006927	TIGR01666 family membrane protein; Region: YCCS
866913006928	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
866913006929	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
866913006930	Predicted membrane protein [Function unknown]; Region: COG3304
866913006931	Domain of unknown function (DUF307); Region: DUF307; pfam03733
866913006932	Domain of unknown function (DUF307); Region: DUF307; pfam03733
866913006933	DNA helicase IV; Provisional; Region: helD; PRK11054
866913006934	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
866913006935	Part of AAA domain; Region: AAA_19; pfam13245
866913006936	Family description; Region: UvrD_C_2; pfam13538
866913006937	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
866913006938	active site
866913006939	dimer interfaces [polypeptide binding]; other site
866913006940	catalytic residues [active]
866913006941	hypothetical protein; Provisional; Region: PRK03641
866913006942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
866913006943	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
866913006944	heat shock protein HspQ; Provisional; Region: PRK14129
866913006945	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
866913006946	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
866913006947	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
866913006948	putative RNA binding site [nucleotide binding]; other site
866913006949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913006950	S-adenosylmethionine binding site [chemical binding]; other site
866913006951	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
866913006952	substrate binding site [chemical binding]; other site
866913006953	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913006954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913006955	acylphosphatase; Provisional; Region: PRK14426
866913006956	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
866913006957	sulfur transfer protein TusE; Provisional; Region: PRK11508
866913006958	YccA-like proteins; Region: YccA_like; cd10433
866913006959	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
866913006960	PipA protein; Region: PipA; pfam07108
866913006961	secreted effector protein PipB; Provisional; Region: PRK15197
866913006962	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913006963	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913006964	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913006965	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
866913006966	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
866913006967	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
866913006968	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
866913006969	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
866913006970	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
866913006971	HAMP domain; Region: HAMP; pfam00672
866913006972	dimerization interface [polypeptide binding]; other site
866913006973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913006974	dimer interface [polypeptide binding]; other site
866913006975	phosphorylation site [posttranslational modification]
866913006976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913006977	ATP binding site [chemical binding]; other site
866913006978	Mg2+ binding site [ion binding]; other site
866913006979	G-X-G motif; other site
866913006980	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
866913006981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913006982	active site
866913006983	phosphorylation site [posttranslational modification]
866913006984	intermolecular recognition site; other site
866913006985	dimerization interface [polypeptide binding]; other site
866913006986	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913006987	DNA binding site [nucleotide binding]
866913006988	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
866913006989	active site
866913006990	homotetramer interface [polypeptide binding]; other site
866913006991	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
866913006992	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
866913006993	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
866913006994	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
866913006995	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866913006996	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
866913006997	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
866913006998	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
866913006999	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
866913007000	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
866913007001	NAD binding site [chemical binding]; other site
866913007002	catalytic residues [active]
866913007003	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
866913007004	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
866913007005	putative active site [active]
866913007006	putative metal binding site [ion binding]; other site
866913007007	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
866913007008	putative substrate binding pocket [chemical binding]; other site
866913007009	trimer interface [polypeptide binding]; other site
866913007010	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
866913007011	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
866913007012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007013	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
866913007014	putative substrate translocation pore; other site
866913007015	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
866913007016	Cupin domain; Region: Cupin_2; pfam07883
866913007017	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913007018	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
866913007019	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
866913007020	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
866913007021	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
866913007022	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866913007023	HSP70 interaction site [polypeptide binding]; other site
866913007024	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
866913007025	substrate binding site [polypeptide binding]; other site
866913007026	dimer interface [polypeptide binding]; other site
866913007027	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
866913007028	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
866913007029	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
866913007030	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
866913007031	DsbD alpha interface [polypeptide binding]; other site
866913007032	catalytic residues [active]
866913007033	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
866913007034	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
866913007035	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
866913007036	catalytic residues [active]
866913007037	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
866913007038	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866913007039	catalytic residues [active]
866913007040	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
866913007041	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
866913007042	catalytic core [active]
866913007043	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
866913007044	hypothetical protein; Provisional; Region: PRK10174
866913007045	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
866913007046	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866913007047	General stress protein [General function prediction only]; Region: GsiB; COG3729
866913007048	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
866913007049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913007050	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
866913007051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
866913007052	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
866913007053	Predicted transcriptional regulator [Transcription]; Region: COG3905
866913007054	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
866913007055	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
866913007056	Glutamate binding site [chemical binding]; other site
866913007057	NAD binding site [chemical binding]; other site
866913007058	catalytic residues [active]
866913007059	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
866913007060	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
866913007061	Na binding site [ion binding]; other site
866913007062	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
866913007063	hypothetical protein; Provisional; Region: PRK10536
866913007064	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
866913007065	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866913007066	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866913007067	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866913007068	putative active site [active]
866913007069	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
866913007070	Na binding site [ion binding]; other site
866913007071	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
866913007072	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
866913007073	putative active site cavity [active]
866913007074	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
866913007075	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
866913007076	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
866913007077	putative sialic acid transporter; Provisional; Region: PRK12307
866913007078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007079	putative substrate translocation pore; other site
866913007080	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866913007081	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866913007082	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866913007083	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
866913007084	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
866913007085	putative ligand binding site [chemical binding]; other site
866913007086	NAD binding site [chemical binding]; other site
866913007087	dimerization interface [polypeptide binding]; other site
866913007088	catalytic site [active]
866913007089	putative hydrolase; Validated; Region: PRK09248
866913007090	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
866913007091	active site
866913007092	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
866913007093	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
866913007094	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
866913007095	curli assembly protein CsgF; Provisional; Region: PRK10050
866913007096	curli assembly protein CsgE; Provisional; Region: PRK10386
866913007097	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
866913007098	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913007099	DNA binding residues [nucleotide binding]
866913007100	dimerization interface [polypeptide binding]; other site
866913007101	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
866913007102	Curlin associated repeat; Region: Curlin_rpt; pfam07012
866913007103	Curlin associated repeat; Region: Curlin_rpt; pfam07012
866913007104	major curlin subunit; Provisional; Region: csgA; PRK10051
866913007105	Curlin associated repeat; Region: Curlin_rpt; pfam07012
866913007106	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
866913007107	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
866913007108	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
866913007109	putative ADP-ribose binding site [chemical binding]; other site
866913007110	putative active site [active]
866913007111	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
866913007112	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
866913007113	putative active site [active]
866913007114	catalytic site [active]
866913007115	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
866913007116	putative active site [active]
866913007117	catalytic site [active]
866913007118	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
866913007119	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866913007120	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
866913007121	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
866913007122	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866913007123	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
866913007124	Ligand binding site; other site
866913007125	DXD motif; other site
866913007126	lipoprotein; Provisional; Region: PRK10175
866913007127	secY/secA suppressor protein; Provisional; Region: PRK11467
866913007128	drug efflux system protein MdtG; Provisional; Region: PRK09874
866913007129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007130	putative substrate translocation pore; other site
866913007131	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
866913007132	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
866913007133	putative acyl-acceptor binding pocket; other site
866913007134	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
866913007135	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
866913007136	active site residue [active]
866913007137	hypothetical protein; Provisional; Region: PRK03757
866913007138	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
866913007139	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
866913007140	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
866913007141	hydroxyglutarate oxidase; Provisional; Region: PRK11728
866913007142	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
866913007143	DNA damage-inducible protein I; Provisional; Region: PRK10597
866913007144	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
866913007145	active site
866913007146	substrate binding pocket [chemical binding]; other site
866913007147	dimer interface [polypeptide binding]; other site
866913007148	lipoprotein; Provisional; Region: PRK10598
866913007149	glutaredoxin 2; Provisional; Region: PRK10387
866913007150	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
866913007151	C-terminal domain interface [polypeptide binding]; other site
866913007152	GSH binding site (G-site) [chemical binding]; other site
866913007153	catalytic residues [active]
866913007154	putative dimer interface [polypeptide binding]; other site
866913007155	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
866913007156	N-terminal domain interface [polypeptide binding]; other site
866913007157	multidrug resistance protein MdtH; Provisional; Region: PRK11646
866913007158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007159	putative substrate translocation pore; other site
866913007160	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
866913007161	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866913007162	hypothetical protein; Provisional; Region: PRK11239
866913007163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
866913007164	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866913007165	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866913007166	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866913007167	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
866913007168	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
866913007169	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
866913007170	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
866913007171	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
866913007172	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
866913007173	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
866913007174	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
866913007175	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
866913007176	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
866913007177	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866913007178	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866913007179	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
866913007180	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
866913007181	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
866913007182	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
866913007183	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866913007184	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
866913007185	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866913007186	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
866913007187	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866913007188	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
866913007189	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
866913007190	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866913007191	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866913007192	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
866913007193	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
866913007194	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
866913007195	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
866913007196	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
866913007197	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
866913007198	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
866913007199	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
866913007200	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
866913007201	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
866913007202	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
866913007203	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
866913007204	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
866913007205	homodimer interface [polypeptide binding]; other site
866913007206	oligonucleotide binding site [chemical binding]; other site
866913007207	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
866913007208	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
866913007209	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913007210	RNA binding surface [nucleotide binding]; other site
866913007211	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866913007212	active site
866913007213	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
866913007214	Maf-like protein; Region: Maf; pfam02545
866913007215	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
866913007216	active site
866913007217	dimer interface [polypeptide binding]; other site
866913007218	hypothetical protein; Provisional; Region: PRK11193
866913007219	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
866913007220	putative phosphate acyltransferase; Provisional; Region: PRK05331
866913007221	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
866913007222	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
866913007223	dimer interface [polypeptide binding]; other site
866913007224	active site
866913007225	CoA binding pocket [chemical binding]; other site
866913007226	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
866913007227	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
866913007228	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
866913007229	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
866913007230	NAD(P) binding site [chemical binding]; other site
866913007231	homotetramer interface [polypeptide binding]; other site
866913007232	homodimer interface [polypeptide binding]; other site
866913007233	active site
866913007234	acyl carrier protein; Provisional; Region: acpP; PRK00982
866913007235	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
866913007236	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
866913007237	dimer interface [polypeptide binding]; other site
866913007238	active site
866913007239	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
866913007240	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
866913007241	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913007242	catalytic residue [active]
866913007243	conserved hypothetical protein, YceG family; Region: TIGR00247
866913007244	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
866913007245	dimerization interface [polypeptide binding]; other site
866913007246	thymidylate kinase; Validated; Region: tmk; PRK00698
866913007247	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
866913007248	TMP-binding site; other site
866913007249	ATP-binding site [chemical binding]; other site
866913007250	DNA polymerase III subunit delta'; Validated; Region: PRK07993
866913007251	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
866913007252	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
866913007253	active site
866913007254	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
866913007255	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866913007256	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866913007257	active site turn [active]
866913007258	phosphorylation site [posttranslational modification]
866913007259	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
866913007260	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913007261	N-terminal plug; other site
866913007262	ligand-binding site [chemical binding]; other site
866913007263	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
866913007264	nucleotide binding site/active site [active]
866913007265	HIT family signature motif; other site
866913007266	catalytic residue [active]
866913007267	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
866913007268	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
866913007269	putative dimer interface [polypeptide binding]; other site
866913007270	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
866913007271	thiamine kinase; Region: ycfN_thiK; TIGR02721
866913007272	thiamine kinase; Provisional; Region: thiK; PRK10271
866913007273	substrate binding site [chemical binding]; other site
866913007274	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
866913007275	beta-hexosaminidase; Provisional; Region: PRK05337
866913007276	hypothetical protein; Provisional; Region: PRK04940
866913007277	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
866913007278	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913007279	hypothetical protein; Provisional; Region: PRK11280
866913007280	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866913007281	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913007282	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913007283	L,D-transpeptidase; Provisional; Region: PRK10190
866913007284	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913007285	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866913007286	transcription-repair coupling factor; Provisional; Region: PRK10689
866913007287	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
866913007288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913007289	ATP binding site [chemical binding]; other site
866913007290	putative Mg++ binding site [ion binding]; other site
866913007291	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913007292	nucleotide binding region [chemical binding]; other site
866913007293	ATP-binding site [chemical binding]; other site
866913007294	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
866913007295	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
866913007296	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866913007297	FtsX-like permease family; Region: FtsX; pfam02687
866913007298	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
866913007299	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866913007300	Walker A/P-loop; other site
866913007301	ATP binding site [chemical binding]; other site
866913007302	Q-loop/lid; other site
866913007303	ABC transporter signature motif; other site
866913007304	Walker B; other site
866913007305	D-loop; other site
866913007306	H-loop/switch region; other site
866913007307	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
866913007308	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866913007309	FtsX-like permease family; Region: FtsX; pfam02687
866913007310	fructokinase; Reviewed; Region: PRK09557
866913007311	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913007312	nucleotide binding site [chemical binding]; other site
866913007313	NAD-dependent deacetylase; Provisional; Region: PRK00481
866913007314	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
866913007315	NAD+ binding site [chemical binding]; other site
866913007316	substrate binding site [chemical binding]; other site
866913007317	Zn binding site [ion binding]; other site
866913007318	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
866913007319	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
866913007320	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
866913007321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913007322	dimer interface [polypeptide binding]; other site
866913007323	conserved gate region; other site
866913007324	putative PBP binding loops; other site
866913007325	ABC-ATPase subunit interface; other site
866913007326	Sif protein; Region: Sif; pfam06767
866913007327	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866913007328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913007329	dimer interface [polypeptide binding]; other site
866913007330	conserved gate region; other site
866913007331	putative PBP binding loops; other site
866913007332	ABC-ATPase subunit interface; other site
866913007333	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
866913007334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913007335	Walker A/P-loop; other site
866913007336	ATP binding site [chemical binding]; other site
866913007337	Q-loop/lid; other site
866913007338	ABC transporter signature motif; other site
866913007339	Walker B; other site
866913007340	D-loop; other site
866913007341	H-loop/switch region; other site
866913007342	TOBE domain; Region: TOBE_2; pfam08402
866913007343	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
866913007344	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
866913007345	metal binding site [ion binding]; metal-binding site
866913007346	dimer interface [polypeptide binding]; other site
866913007347	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913007348	Uncharacterized conserved protein [Function unknown]; Region: COG2850
866913007349	Cupin-like domain; Region: Cupin_8; pfam13621
866913007350	sensor protein PhoQ; Provisional; Region: PRK10815
866913007351	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
866913007352	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
866913007353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913007354	ATP binding site [chemical binding]; other site
866913007355	Mg2+ binding site [ion binding]; other site
866913007356	G-X-G motif; other site
866913007357	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
866913007358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913007359	active site
866913007360	phosphorylation site [posttranslational modification]
866913007361	intermolecular recognition site; other site
866913007362	dimerization interface [polypeptide binding]; other site
866913007363	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913007364	DNA binding site [nucleotide binding]
866913007365	adenylosuccinate lyase; Provisional; Region: PRK09285
866913007366	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
866913007367	tetramer interface [polypeptide binding]; other site
866913007368	active site
866913007369	putative lysogenization regulator; Reviewed; Region: PRK00218
866913007370	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
866913007371	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
866913007372	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
866913007373	nudix motif; other site
866913007374	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
866913007375	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
866913007376	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
866913007377	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
866913007378	probable active site [active]
866913007379	isocitrate dehydrogenase; Validated; Region: PRK07362
866913007380	isocitrate dehydrogenase; Reviewed; Region: PRK07006
866913007381	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
866913007382	DinI-like family; Region: DinI; pfam06183
866913007383	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
866913007384	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
866913007385	putative sugar binding sites [chemical binding]; other site
866913007386	Q-X-W motif; other site
866913007387	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866913007388	DNA-binding site [nucleotide binding]; DNA binding site
866913007389	RNA-binding motif; other site
866913007390	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
866913007391	lysozyme inhibitor; Provisional; Region: PRK13791
866913007392	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
866913007393	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
866913007394	putative dimer interface [polypeptide binding]; other site
866913007395	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
866913007396	BNR repeat-like domain; Region: BNR_2; pfam13088
866913007397	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
866913007398	TRL-like protein family; Region: TRL; pfam13146
866913007399	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
866913007400	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
866913007401	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866913007402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913007403	dimer interface [polypeptide binding]; other site
866913007404	conserved gate region; other site
866913007405	ABC-ATPase subunit interface; other site
866913007406	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866913007407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913007408	dimer interface [polypeptide binding]; other site
866913007409	conserved gate region; other site
866913007410	putative PBP binding loops; other site
866913007411	ABC-ATPase subunit interface; other site
866913007412	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913007413	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
866913007414	Walker A/P-loop; other site
866913007415	ATP binding site [chemical binding]; other site
866913007416	Q-loop/lid; other site
866913007417	ABC transporter signature motif; other site
866913007418	Walker B; other site
866913007419	D-loop; other site
866913007420	H-loop/switch region; other site
866913007421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913007422	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
866913007423	Walker A/P-loop; other site
866913007424	ATP binding site [chemical binding]; other site
866913007425	Q-loop/lid; other site
866913007426	ABC transporter signature motif; other site
866913007427	Walker B; other site
866913007428	D-loop; other site
866913007429	H-loop/switch region; other site
866913007430	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866913007431	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913007432	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
866913007433	dimerization interface [polypeptide binding]; other site
866913007434	zinc/cadmium-binding protein; Provisional; Region: PRK10306
866913007435	aminoglycoside resistance protein; Provisional; Region: PRK13746
866913007436	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
866913007437	active site
866913007438	NTP binding site [chemical binding]; other site
866913007439	metal binding triad [ion binding]; metal-binding site
866913007440	antibiotic binding site [chemical binding]; other site
866913007441	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
866913007442	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913007443	DNA binding residues [nucleotide binding]
866913007444	transcriptional regulator MirA; Provisional; Region: PRK15043
866913007445	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
866913007446	DNA binding residues [nucleotide binding]
866913007447	dimer interface [polypeptide binding]; other site
866913007448	Pleckstrin homology-like domain; Region: PH-like; cl17171
866913007449	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
866913007450	chorismate mutase; Provisional; Region: PRK08055
866913007451	leucine export protein LeuE; Provisional; Region: PRK10958
866913007452	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
866913007453	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
866913007454	hypothetical protein; Provisional; Region: PRK10457
866913007455	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
866913007456	murein hydrolase B; Provisional; Region: PRK10760; cl17906
866913007457	Domain of unknown function (DUF333); Region: DUF333; pfam03891
866913007458	Uncharacterized conserved protein [Function unknown]; Region: COG3189
866913007459	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
866913007460	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007461	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913007462	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913007463	Predicted membrane protein [Function unknown]; Region: COG2707
866913007464	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
866913007465	putative deacylase active site [active]
866913007466	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866913007467	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913007468	metal binding site [ion binding]; metal-binding site
866913007469	active site
866913007470	I-site; other site
866913007471	hypothetical protein; Provisional; Region: PRK05325
866913007472	PrkA family serine protein kinase; Provisional; Region: PRK15455
866913007473	AAA ATPase domain; Region: AAA_16; pfam13191
866913007474	Walker A motif; other site
866913007475	ATP binding site [chemical binding]; other site
866913007476	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
866913007477	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
866913007478	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
866913007479	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913007480	FeS/SAM binding site; other site
866913007481	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
866913007482	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913007483	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913007484	active site
866913007485	catalytic tetrad [active]
866913007486	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
866913007487	active site
866913007488	phosphate binding residues; other site
866913007489	catalytic residues [active]
866913007490	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
866913007491	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
866913007492	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
866913007493	methionine sulfoxide reductase B; Provisional; Region: PRK00222
866913007494	SelR domain; Region: SelR; pfam01641
866913007495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
866913007496	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
866913007497	Isochorismatase family; Region: Isochorismatase; pfam00857
866913007498	catalytic triad [active]
866913007499	metal binding site [ion binding]; metal-binding site
866913007500	conserved cis-peptide bond; other site
866913007501	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
866913007502	active site
866913007503	homodimer interface [polypeptide binding]; other site
866913007504	protease 4; Provisional; Region: PRK10949
866913007505	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
866913007506	tandem repeat interface [polypeptide binding]; other site
866913007507	oligomer interface [polypeptide binding]; other site
866913007508	active site residues [active]
866913007509	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
866913007510	tandem repeat interface [polypeptide binding]; other site
866913007511	oligomer interface [polypeptide binding]; other site
866913007512	active site residues [active]
866913007513	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
866913007514	putative FMN binding site [chemical binding]; other site
866913007515	selenophosphate synthetase; Provisional; Region: PRK00943
866913007516	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
866913007517	dimerization interface [polypeptide binding]; other site
866913007518	putative ATP binding site [chemical binding]; other site
866913007519	DNA topoisomerase III; Provisional; Region: PRK07726
866913007520	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
866913007521	active site
866913007522	putative interdomain interaction site [polypeptide binding]; other site
866913007523	putative metal-binding site [ion binding]; other site
866913007524	putative nucleotide binding site [chemical binding]; other site
866913007525	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
866913007526	domain I; other site
866913007527	DNA binding groove [nucleotide binding]
866913007528	phosphate binding site [ion binding]; other site
866913007529	domain II; other site
866913007530	domain III; other site
866913007531	nucleotide binding site [chemical binding]; other site
866913007532	catalytic site [active]
866913007533	domain IV; other site
866913007534	glutamate dehydrogenase; Provisional; Region: PRK09414
866913007535	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
866913007536	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
866913007537	NAD(P) binding site [chemical binding]; other site
866913007538	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
866913007539	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
866913007540	active site
866913007541	8-oxo-dGMP binding site [chemical binding]; other site
866913007542	nudix motif; other site
866913007543	metal binding site [ion binding]; metal-binding site
866913007544	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
866913007545	putative catalytic site [active]
866913007546	putative phosphate binding site [ion binding]; other site
866913007547	active site
866913007548	metal binding site A [ion binding]; metal-binding site
866913007549	DNA binding site [nucleotide binding]
866913007550	putative AP binding site [nucleotide binding]; other site
866913007551	putative metal binding site B [ion binding]; other site
866913007552	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
866913007553	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866913007554	inhibitor-cofactor binding pocket; inhibition site
866913007555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913007556	catalytic residue [active]
866913007557	arginine succinyltransferase; Provisional; Region: PRK10456
866913007558	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
866913007559	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
866913007560	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
866913007561	NAD(P) binding site [chemical binding]; other site
866913007562	catalytic residues [active]
866913007563	succinylarginine dihydrolase; Provisional; Region: PRK13281
866913007564	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
866913007565	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
866913007566	putative active site [active]
866913007567	Zn binding site [ion binding]; other site
866913007568	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
866913007569	dimer interface [polypeptide binding]; other site
866913007570	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
866913007571	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
866913007572	GIY-YIG motif/motif A; other site
866913007573	active site
866913007574	catalytic site [active]
866913007575	putative DNA binding site [nucleotide binding]; other site
866913007576	metal binding site [ion binding]; metal-binding site
866913007577	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
866913007578	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
866913007579	homodimer interface [polypeptide binding]; other site
866913007580	NAD binding pocket [chemical binding]; other site
866913007581	ATP binding pocket [chemical binding]; other site
866913007582	Mg binding site [ion binding]; other site
866913007583	active-site loop [active]
866913007584	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
866913007585	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
866913007586	active site
866913007587	P-loop; other site
866913007588	phosphorylation site [posttranslational modification]
866913007589	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
866913007590	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
866913007591	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
866913007592	methionine cluster; other site
866913007593	active site
866913007594	phosphorylation site [posttranslational modification]
866913007595	metal binding site [ion binding]; metal-binding site
866913007596	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
866913007597	Cupin domain; Region: Cupin_2; pfam07883
866913007598	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913007599	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
866913007600	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
866913007601	NAD binding site [chemical binding]; other site
866913007602	sugar binding site [chemical binding]; other site
866913007603	divalent metal binding site [ion binding]; other site
866913007604	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866913007605	dimer interface [polypeptide binding]; other site
866913007606	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
866913007607	putative active site [active]
866913007608	YdjC motif; other site
866913007609	Mg binding site [ion binding]; other site
866913007610	putative homodimer interface [polypeptide binding]; other site
866913007611	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913007612	hydroperoxidase II; Provisional; Region: katE; PRK11249
866913007613	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
866913007614	tetramer interface [polypeptide binding]; other site
866913007615	heme binding pocket [chemical binding]; other site
866913007616	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
866913007617	domain interactions; other site
866913007618	cell division modulator; Provisional; Region: PRK10113
866913007619	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
866913007620	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866913007621	inner membrane protein; Provisional; Region: PRK11648
866913007622	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
866913007623	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866913007624	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913007625	motif II; other site
866913007626	YniB-like protein; Region: YniB; pfam14002
866913007627	Phosphotransferase enzyme family; Region: APH; pfam01636
866913007628	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
866913007629	active site
866913007630	ATP binding site [chemical binding]; other site
866913007631	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
866913007632	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
866913007633	6-phosphofructokinase 2; Provisional; Region: PRK10294
866913007634	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
866913007635	putative substrate binding site [chemical binding]; other site
866913007636	putative ATP binding site [chemical binding]; other site
866913007637	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
866913007638	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
866913007639	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
866913007640	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
866913007641	active site
866913007642	substrate binding site [chemical binding]; other site
866913007643	Mg2+ binding site [ion binding]; other site
866913007644	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
866913007645	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
866913007646	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
866913007647	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
866913007648	active site
866913007649	dimer interface [polypeptide binding]; other site
866913007650	motif 1; other site
866913007651	motif 2; other site
866913007652	motif 3; other site
866913007653	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
866913007654	anticodon binding site; other site
866913007655	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
866913007656	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
866913007657	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
866913007658	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
866913007659	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
866913007660	23S rRNA binding site [nucleotide binding]; other site
866913007661	L21 binding site [polypeptide binding]; other site
866913007662	L13 binding site [polypeptide binding]; other site
866913007663	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
866913007664	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
866913007665	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
866913007666	dimer interface [polypeptide binding]; other site
866913007667	motif 1; other site
866913007668	active site
866913007669	motif 2; other site
866913007670	motif 3; other site
866913007671	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
866913007672	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
866913007673	putative tRNA-binding site [nucleotide binding]; other site
866913007674	B3/4 domain; Region: B3_4; pfam03483
866913007675	tRNA synthetase B5 domain; Region: B5; smart00874
866913007676	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
866913007677	dimer interface [polypeptide binding]; other site
866913007678	motif 1; other site
866913007679	motif 3; other site
866913007680	motif 2; other site
866913007681	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
866913007682	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
866913007683	IHF dimer interface [polypeptide binding]; other site
866913007684	IHF - DNA interface [nucleotide binding]; other site
866913007685	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866913007686	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913007687	ABC-ATPase subunit  interface; other site
866913007688	dimer interface [polypeptide binding]; other site
866913007689	putative PBP binding regions; other site
866913007690	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
866913007691	catalytic residues [active]
866913007692	dimer interface [polypeptide binding]; other site
866913007693	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
866913007694	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866913007695	Walker A/P-loop; other site
866913007696	ATP binding site [chemical binding]; other site
866913007697	Q-loop/lid; other site
866913007698	ABC transporter signature motif; other site
866913007699	Walker B; other site
866913007700	D-loop; other site
866913007701	H-loop/switch region; other site
866913007702	NlpC/P60 family; Region: NLPC_P60; pfam00877
866913007703	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
866913007704	Uncharacterized conserved protein [Function unknown]; Region: COG0397
866913007705	hypothetical protein; Validated; Region: PRK00029
866913007706	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
866913007707	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
866913007708	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
866913007709	PEP synthetase regulatory protein; Provisional; Region: PRK05339
866913007710	phosphoenolpyruvate synthase; Validated; Region: PRK06464
866913007711	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
866913007712	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866913007713	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866913007714	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
866913007715	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
866913007716	acyl-activating enzyme (AAE) consensus motif; other site
866913007717	putative AMP binding site [chemical binding]; other site
866913007718	putative active site [active]
866913007719	putative CoA binding site [chemical binding]; other site
866913007720	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
866913007721	oxidoreductase; Provisional; Region: PRK10015
866913007722	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
866913007723	Electron transfer flavoprotein domain; Region: ETF; smart00893
866913007724	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
866913007725	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
866913007726	Ligand binding site [chemical binding]; other site
866913007727	Electron transfer flavoprotein domain; Region: ETF; pfam01012
866913007728	Cupin domain; Region: Cupin_2; pfam07883
866913007729	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913007730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913007731	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
866913007732	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
866913007733	active site
866913007734	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
866913007735	Coenzyme A transferase; Region: CoA_trans; smart00882
866913007736	Coenzyme A transferase; Region: CoA_trans; cl17247
866913007737	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
866913007738	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
866913007739	active site
866913007740	catalytic residue [active]
866913007741	dimer interface [polypeptide binding]; other site
866913007742	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
866913007743	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
866913007744	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
866913007745	shikimate binding site; other site
866913007746	NAD(P) binding site [chemical binding]; other site
866913007747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007748	putative transporter; Provisional; Region: PRK03699
866913007749	putative substrate translocation pore; other site
866913007750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007751	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913007752	putative substrate translocation pore; other site
866913007753	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
866913007754	putative inner membrane protein; Provisional; Region: PRK10983
866913007755	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866913007756	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
866913007757	FAD binding domain; Region: FAD_binding_4; pfam01565
866913007758	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
866913007759	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
866913007760	CoenzymeA binding site [chemical binding]; other site
866913007761	subunit interaction site [polypeptide binding]; other site
866913007762	PHB binding site; other site
866913007763	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
866913007764	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866913007765	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
866913007766	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
866913007767	putative ABC transporter; Region: ycf24; CHL00085
866913007768	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
866913007769	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
866913007770	Walker A/P-loop; other site
866913007771	ATP binding site [chemical binding]; other site
866913007772	Q-loop/lid; other site
866913007773	ABC transporter signature motif; other site
866913007774	Walker B; other site
866913007775	D-loop; other site
866913007776	H-loop/switch region; other site
866913007777	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
866913007778	FeS assembly protein SufD; Region: sufD; TIGR01981
866913007779	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
866913007780	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
866913007781	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913007782	catalytic residue [active]
866913007783	cysteine desufuration protein SufE; Provisional; Region: PRK09296
866913007784	L,D-transpeptidase; Provisional; Region: PRK10190
866913007785	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913007786	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866913007787	murein lipoprotein; Provisional; Region: PRK15396
866913007788	murein lipoprotein; Provisional; Region: PRK15396
866913007789	pyruvate kinase; Provisional; Region: PRK09206
866913007790	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
866913007791	domain interfaces; other site
866913007792	active site
866913007793	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
866913007794	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
866913007795	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
866913007796	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913007797	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866913007798	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913007799	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866913007800	substrate binding site [chemical binding]; other site
866913007801	dimer interface [polypeptide binding]; other site
866913007802	ATP binding site [chemical binding]; other site
866913007803	tetrathionate reductase subunit A; Provisional; Region: PRK14991
866913007804	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
866913007805	putative [Fe4-S4] binding site [ion binding]; other site
866913007806	putative molybdopterin cofactor binding site [chemical binding]; other site
866913007807	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
866913007808	putative molybdopterin cofactor binding site; other site
866913007809	tetrathionate reductase subunit C; Provisional; Region: PRK14992
866913007810	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
866913007811	tetrathionate reductase subunit B; Provisional; Region: PRK14993
866913007812	4Fe-4S binding domain; Region: Fer4; pfam00037
866913007813	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
866913007814	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
866913007815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866913007816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913007817	dimer interface [polypeptide binding]; other site
866913007818	phosphorylation site [posttranslational modification]
866913007819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913007820	ATP binding site [chemical binding]; other site
866913007821	Mg2+ binding site [ion binding]; other site
866913007822	G-X-G motif; other site
866913007823	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
866913007824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913007825	active site
866913007826	phosphorylation site [posttranslational modification]
866913007827	intermolecular recognition site; other site
866913007828	dimerization interface [polypeptide binding]; other site
866913007829	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913007830	DNA binding residues [nucleotide binding]
866913007831	dimerization interface [polypeptide binding]; other site
866913007832	hypothetical protein; Provisional; Region: PRK10292
866913007833	Uncharacterized conserved protein [Function unknown]; Region: COG1683
866913007834	Uncharacterized conserved protein [Function unknown]; Region: COG3272
866913007835	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
866913007836	transcriptional regulator MirA; Provisional; Region: PRK15043
866913007837	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
866913007838	DNA binding residues [nucleotide binding]
866913007839	two component system sensor kinase SsrB; Provisional; Region: PRK15369
866913007840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913007841	active site
866913007842	phosphorylation site [posttranslational modification]
866913007843	intermolecular recognition site; other site
866913007844	dimerization interface [polypeptide binding]; other site
866913007845	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913007846	DNA binding residues [nucleotide binding]
866913007847	dimerization interface [polypeptide binding]; other site
866913007848	two component system sensor kinase SsrA; Provisional; Region: PRK15347
866913007849	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913007850	dimerization interface [polypeptide binding]; other site
866913007851	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913007852	dimer interface [polypeptide binding]; other site
866913007853	phosphorylation site [posttranslational modification]
866913007854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913007855	ATP binding site [chemical binding]; other site
866913007856	Mg2+ binding site [ion binding]; other site
866913007857	G-X-G motif; other site
866913007858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913007859	active site
866913007860	phosphorylation site [posttranslational modification]
866913007861	intermolecular recognition site; other site
866913007862	dimerization interface [polypeptide binding]; other site
866913007863	pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368
866913007864	outer membrane secretin SsaC; Provisional; Region: PRK15346
866913007865	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
866913007866	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
866913007867	type III secretion system protein SsaD; Provisional; Region: PRK15367
866913007868	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
866913007869	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
866913007870	type III secretion system chaperone SseA; Provisional; Region: PRK15365
866913007871	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
866913007872	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
866913007873	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
866913007874	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
866913007875	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
866913007876	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
866913007877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866913007878	TPR motif; other site
866913007879	binding surface
866913007880	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
866913007881	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
866913007882	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
866913007883	type III secretion system protein SsaH; Provisional; Region: PRK15356
866913007884	type III secretion system protein SsaI; Provisional; Region: PRK15355
866913007885	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
866913007886	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
866913007887	type III secretion system protein SsaK; Provisional; Region: PRK15354
866913007888	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
866913007889	type III secretion system protein SsaL; Provisional; Region: PRK15345
866913007890	HrpJ-like domain; Region: HrpJ; pfam07201
866913007891	TyeA; Region: TyeA; cl07611
866913007892	type III secretion system protein SsaM; Provisional; Region: PRK15353
866913007893	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
866913007894	FHIPEP family; Region: FHIPEP; pfam00771
866913007895	type III secretion system ATPase SsaN; Validated; Region: PRK07594
866913007896	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866913007897	Walker A motif; other site
866913007898	ATP binding site [chemical binding]; other site
866913007899	Walker B motif; other site
866913007900	type III secretion system protein SsaO; Provisional; Region: PRK15352
866913007901	type III secretion system protein SsaP; Provisional; Region: PRK15351
866913007902	type III secretion system protein SsaQ; Validated; Region: PRK08035
866913007903	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
866913007904	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
866913007905	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
866913007906	type III secretion system protein SsaS; Provisional; Region: PRK15350
866913007907	type III secretion system protein SsaT; Provisional; Region: PRK15349
866913007908	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
866913007909	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
866913007910	multidrug efflux protein; Reviewed; Region: PRK01766
866913007911	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
866913007912	cation binding site [ion binding]; other site
866913007913	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
866913007914	Lumazine binding domain; Region: Lum_binding; pfam00677
866913007915	Lumazine binding domain; Region: Lum_binding; pfam00677
866913007916	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
866913007917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913007918	S-adenosylmethionine binding site [chemical binding]; other site
866913007919	putative transporter; Provisional; Region: PRK11043
866913007920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913007921	putative substrate translocation pore; other site
866913007922	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
866913007923	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913007924	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913007925	dimerization interface [polypeptide binding]; other site
866913007926	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
866913007927	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913007928	DNA binding site [nucleotide binding]
866913007929	domain linker motif; other site
866913007930	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
866913007931	dimerization interface [polypeptide binding]; other site
866913007932	ligand binding site [chemical binding]; other site
866913007933	superoxide dismutase; Provisional; Region: PRK10543
866913007934	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
866913007935	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
866913007936	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866913007937	NlpC/P60 family; Region: NLPC_P60; pfam00877
866913007938	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
866913007939	putative GSH binding site [chemical binding]; other site
866913007940	catalytic residues [active]
866913007941	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
866913007942	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
866913007943	dimer interface [polypeptide binding]; other site
866913007944	catalytic site [active]
866913007945	putative active site [active]
866913007946	putative substrate binding site [chemical binding]; other site
866913007947	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866913007948	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
866913007949	dimer interface [polypeptide binding]; other site
866913007950	active site
866913007951	metal binding site [ion binding]; metal-binding site
866913007952	glutathione binding site [chemical binding]; other site
866913007953	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866913007954	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
866913007955	FMN binding site [chemical binding]; other site
866913007956	active site
866913007957	substrate binding site [chemical binding]; other site
866913007958	catalytic residue [active]
866913007959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866913007960	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913007961	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913007962	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913007963	active site
866913007964	catalytic tetrad [active]
866913007965	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
866913007966	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
866913007967	E-class dimer interface [polypeptide binding]; other site
866913007968	P-class dimer interface [polypeptide binding]; other site
866913007969	active site
866913007970	Cu2+ binding site [ion binding]; other site
866913007971	Zn2+ binding site [ion binding]; other site
866913007972	Fusaric acid resistance protein family; Region: FUSC; pfam04632
866913007973	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
866913007974	HlyD family secretion protein; Region: HlyD; pfam00529
866913007975	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913007976	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913007977	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
866913007978	transcriptional regulator SlyA; Provisional; Region: PRK03573
866913007979	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
866913007980	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
866913007981	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
866913007982	lysozyme inhibitor; Provisional; Region: PRK11372
866913007983	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
866913007984	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
866913007985	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
866913007986	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
866913007987	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
866913007988	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
866913007989	active site
866913007990	HIGH motif; other site
866913007991	dimer interface [polypeptide binding]; other site
866913007992	KMSKS motif; other site
866913007993	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913007994	RNA binding surface [nucleotide binding]; other site
866913007995	pyridoxamine kinase; Validated; Region: PRK05756
866913007996	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
866913007997	dimer interface [polypeptide binding]; other site
866913007998	pyridoxal binding site [chemical binding]; other site
866913007999	ATP binding site [chemical binding]; other site
866913008000	glutathionine S-transferase; Provisional; Region: PRK10542
866913008001	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
866913008002	C-terminal domain interface [polypeptide binding]; other site
866913008003	GSH binding site (G-site) [chemical binding]; other site
866913008004	dimer interface [polypeptide binding]; other site
866913008005	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
866913008006	dimer interface [polypeptide binding]; other site
866913008007	N-terminal domain interface [polypeptide binding]; other site
866913008008	substrate binding pocket (H-site) [chemical binding]; other site
866913008009	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
866913008010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008011	putative substrate translocation pore; other site
866913008012	POT family; Region: PTR2; pfam00854
866913008013	endonuclease III; Provisional; Region: PRK10702
866913008014	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866913008015	minor groove reading motif; other site
866913008016	helix-hairpin-helix signature motif; other site
866913008017	substrate binding pocket [chemical binding]; other site
866913008018	active site
866913008019	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
866913008020	electron transport complex RsxE subunit; Provisional; Region: PRK12405
866913008021	electron transport complex protein RnfG; Validated; Region: PRK01908
866913008022	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
866913008023	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
866913008024	SLBB domain; Region: SLBB; pfam10531
866913008025	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866913008026	electron transport complex protein RnfB; Provisional; Region: PRK05113
866913008027	Putative Fe-S cluster; Region: FeS; cl17515
866913008028	4Fe-4S binding domain; Region: Fer4; pfam00037
866913008029	electron transport complex protein RsxA; Provisional; Region: PRK05151
866913008030	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
866913008031	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
866913008032	putative oxidoreductase; Provisional; Region: PRK11579
866913008033	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866913008034	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866913008035	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
866913008036	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
866913008037	active site
866913008038	purine riboside binding site [chemical binding]; other site
866913008039	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
866913008040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
866913008041	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
866913008042	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
866913008043	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
866913008044	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
866913008045	fumarate hydratase; Provisional; Region: PRK15389
866913008046	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
866913008047	Fumarase C-terminus; Region: Fumerase_C; pfam05683
866913008048	fumarate hydratase; Reviewed; Region: fumC; PRK00485
866913008049	Class II fumarases; Region: Fumarase_classII; cd01362
866913008050	active site
866913008051	tetramer interface [polypeptide binding]; other site
866913008052	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
866913008053	sensor protein RstB; Provisional; Region: PRK10604
866913008054	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913008055	dimerization interface [polypeptide binding]; other site
866913008056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913008057	dimer interface [polypeptide binding]; other site
866913008058	phosphorylation site [posttranslational modification]
866913008059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913008060	ATP binding site [chemical binding]; other site
866913008061	Mg2+ binding site [ion binding]; other site
866913008062	G-X-G motif; other site
866913008063	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
866913008064	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
866913008065	active site
866913008066	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913008067	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
866913008068	trimer interface [polypeptide binding]; other site
866913008069	eyelet of channel; other site
866913008070	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
866913008071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913008072	active site
866913008073	phosphorylation site [posttranslational modification]
866913008074	intermolecular recognition site; other site
866913008075	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913008076	DNA binding site [nucleotide binding]
866913008077	GlpM protein; Region: GlpM; pfam06942
866913008078	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
866913008079	Spore germination protein; Region: Spore_permease; cl17796
866913008080	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913008081	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913008082	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913008083	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
866913008084	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
866913008085	ligand binding site [chemical binding]; other site
866913008086	homodimer interface [polypeptide binding]; other site
866913008087	NAD(P) binding site [chemical binding]; other site
866913008088	trimer interface B [polypeptide binding]; other site
866913008089	trimer interface A [polypeptide binding]; other site
866913008090	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
866913008091	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
866913008092	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
866913008093	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
866913008094	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866913008095	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
866913008096	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
866913008097	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
866913008098	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866913008099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008100	putative substrate translocation pore; other site
866913008101	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
866913008102	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913008103	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
866913008104	dimerization interface [polypeptide binding]; other site
866913008105	substrate binding pocket [chemical binding]; other site
866913008106	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
866913008107	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866913008108	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913008109	putative dithiobiotin synthetase; Provisional; Region: PRK12374
866913008110	AAA domain; Region: AAA_26; pfam13500
866913008111	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
866913008112	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
866913008113	Cl- selectivity filter; other site
866913008114	Cl- binding residues [ion binding]; other site
866913008115	pore gating glutamate residue; other site
866913008116	dimer interface [polypeptide binding]; other site
866913008117	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
866913008118	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
866913008119	Walker A/P-loop; other site
866913008120	ATP binding site [chemical binding]; other site
866913008121	Q-loop/lid; other site
866913008122	ABC transporter signature motif; other site
866913008123	Walker B; other site
866913008124	D-loop; other site
866913008125	H-loop/switch region; other site
866913008126	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
866913008127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008128	dimer interface [polypeptide binding]; other site
866913008129	conserved gate region; other site
866913008130	ABC-ATPase subunit interface; other site
866913008131	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
866913008132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008133	dimer interface [polypeptide binding]; other site
866913008134	conserved gate region; other site
866913008135	putative PBP binding loops; other site
866913008136	ABC-ATPase subunit interface; other site
866913008137	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
866913008138	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
866913008139	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
866913008140	4Fe-4S binding domain; Region: Fer4; pfam00037
866913008141	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
866913008142	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
866913008143	putative [Fe4-S4] binding site [ion binding]; other site
866913008144	putative molybdopterin cofactor binding site [chemical binding]; other site
866913008145	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
866913008146	putative molybdopterin cofactor binding site; other site
866913008147	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
866913008148	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
866913008149	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
866913008150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913008151	Coenzyme A binding pocket [chemical binding]; other site
866913008152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866913008153	hypothetical protein; Provisional; Region: PRK13659
866913008154	hypothetical protein; Provisional; Region: PRK02237
866913008155	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
866913008156	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
866913008157	putative active site pocket [active]
866913008158	putative metal binding site [ion binding]; other site
866913008159	putative oxidoreductase; Provisional; Region: PRK10083
866913008160	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
866913008161	putative NAD(P) binding site [chemical binding]; other site
866913008162	catalytic Zn binding site [ion binding]; other site
866913008163	structural Zn binding site [ion binding]; other site
866913008164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008165	putative substrate translocation pore; other site
866913008166	metabolite-proton symporter; Region: 2A0106; TIGR00883
866913008167	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
866913008168	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
866913008169	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
866913008170	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
866913008171	Transcriptional regulators [Transcription]; Region: GntR; COG1802
866913008172	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913008173	DNA-binding site [nucleotide binding]; DNA binding site
866913008174	FCD domain; Region: FCD; pfam07729
866913008175	malonic semialdehyde reductase; Provisional; Region: PRK10538
866913008176	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
866913008177	putative NAD(P) binding site [chemical binding]; other site
866913008178	homodimer interface [polypeptide binding]; other site
866913008179	homotetramer interface [polypeptide binding]; other site
866913008180	active site
866913008181	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
866913008182	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
866913008183	active site
866913008184	Zn binding site [ion binding]; other site
866913008185	General stress protein [General function prediction only]; Region: GsiB; COG3729
866913008186	hypothetical protein; Validated; Region: PRK03657
866913008187	hypothetical protein; Provisional; Region: PRK10053
866913008188	putative transporter; Provisional; Region: PRK10054
866913008189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008190	putative substrate translocation pore; other site
866913008191	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
866913008192	EamA-like transporter family; Region: EamA; pfam00892
866913008193	MarB protein; Region: MarB; pfam13999
866913008194	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
866913008195	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913008196	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913008197	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
866913008198	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866913008199	inner membrane protein; Provisional; Region: PRK10995
866913008200	putative arabinose transporter; Provisional; Region: PRK03545
866913008201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008202	putative substrate translocation pore; other site
866913008203	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913008204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913008205	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
866913008206	putative dimerization interface [polypeptide binding]; other site
866913008207	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
866913008208	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
866913008209	NAD(P) binding site [chemical binding]; other site
866913008210	catalytic residues [active]
866913008211	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
866913008212	glutaminase; Provisional; Region: PRK00971
866913008213	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
866913008214	Predicted membrane protein [Function unknown]; Region: COG3781
866913008215	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
866913008216	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913008217	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
866913008218	trimer interface [polypeptide binding]; other site
866913008219	eyelet of channel; other site
866913008220	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
866913008221	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
866913008222	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
866913008223	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
866913008224	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
866913008225	Rubredoxin [Energy production and conversion]; Region: COG1773
866913008226	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
866913008227	iron binding site [ion binding]; other site
866913008228	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
866913008229	HupF/HypC family; Region: HupF_HypC; cl00394
866913008230	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
866913008231	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
866913008232	putative substrate-binding site; other site
866913008233	nickel binding site [ion binding]; other site
866913008234	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
866913008235	hydrogenase 1 large subunit; Provisional; Region: PRK10170
866913008236	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
866913008237	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
866913008238	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
866913008239	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
866913008240	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
866913008241	active site
866913008242	Transcriptional regulators [Transcription]; Region: FadR; COG2186
866913008243	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913008244	DNA-binding site [nucleotide binding]; DNA binding site
866913008245	FCD domain; Region: FCD; pfam07729
866913008246	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
866913008247	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
866913008248	putative NAD(P) binding site [chemical binding]; other site
866913008249	catalytic Zn binding site [ion binding]; other site
866913008250	structural Zn binding site [ion binding]; other site
866913008251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008252	D-galactonate transporter; Region: 2A0114; TIGR00893
866913008253	putative substrate translocation pore; other site
866913008254	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
866913008255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008256	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913008257	putative substrate translocation pore; other site
866913008258	hypothetical protein; Provisional; Region: PRK06184
866913008259	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866913008260	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866913008261	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866913008262	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913008263	putative DNA binding site [nucleotide binding]; other site
866913008264	putative Zn2+ binding site [ion binding]; other site
866913008265	S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809
866913008266	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
866913008267	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
866913008268	homotrimer interaction site [polypeptide binding]; other site
866913008269	putative active site [active]
866913008270	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
866913008271	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
866913008272	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
866913008273	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866913008274	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913008275	DNA binding site [nucleotide binding]
866913008276	domain linker motif; other site
866913008277	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
866913008278	dimerization interface (closed form) [polypeptide binding]; other site
866913008279	ligand binding site [chemical binding]; other site
866913008280	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
866913008281	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
866913008282	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913008283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913008284	homodimer interface [polypeptide binding]; other site
866913008285	catalytic residue [active]
866913008286	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
866913008287	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
866913008288	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
866913008289	active site
866913008290	catalytic site [active]
866913008291	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
866913008292	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
866913008293	active site
866913008294	catalytic site [active]
866913008295	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
866913008296	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
866913008297	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
866913008298	catalytic site [active]
866913008299	active site
866913008300	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
866913008301	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
866913008302	acid-resistance protein; Provisional; Region: hdeB; PRK11566
866913008303	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
866913008304	biofilm-dependent modulation protein; Provisional; Region: PRK11436
866913008305	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
866913008306	malate dehydrogenase; Provisional; Region: PRK13529
866913008307	Malic enzyme, N-terminal domain; Region: malic; pfam00390
866913008308	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
866913008309	NAD(P) binding site [chemical binding]; other site
866913008310	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
866913008311	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
866913008312	NAD binding site [chemical binding]; other site
866913008313	substrate binding site [chemical binding]; other site
866913008314	catalytic Zn binding site [ion binding]; other site
866913008315	tetramer interface [polypeptide binding]; other site
866913008316	structural Zn binding site [ion binding]; other site
866913008317	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
866913008318	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
866913008319	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
866913008320	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
866913008321	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008322	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008323	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
866913008324	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
866913008325	molybdopterin cofactor binding site; other site
866913008326	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008327	aromatic amino acid exporter; Provisional; Region: PRK11689
866913008328	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913008329	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
866913008330	trimer interface [polypeptide binding]; other site
866913008331	eyelet of channel; other site
866913008332	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
866913008333	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
866913008334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913008335	putative substrate translocation pore; other site
866913008336	TetR family transcriptional regulator; Provisional; Region: PRK14996
866913008337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913008338	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
866913008339	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
866913008340	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
866913008341	[4Fe-4S] binding site [ion binding]; other site
866913008342	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008343	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008344	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008345	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
866913008346	molybdopterin cofactor binding site; other site
866913008347	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
866913008348	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
866913008349	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
866913008350	hypothetical protein; Provisional; Region: PRK10281
866913008351	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
866913008352	L-asparagine permease; Provisional; Region: PRK15049
866913008353	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
866913008354	Uncharacterized conserved protein [Function unknown]; Region: COG3391
866913008355	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
866913008356	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
866913008357	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913008358	N-terminal plug; other site
866913008359	ligand-binding site [chemical binding]; other site
866913008360	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
866913008361	DNA-binding site [nucleotide binding]; DNA binding site
866913008362	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
866913008363	FCD domain; Region: FCD; pfam07729
866913008364	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
866913008365	Prostaglandin dehydrogenases; Region: PGDH; cd05288
866913008366	NAD(P) binding site [chemical binding]; other site
866913008367	substrate binding site [chemical binding]; other site
866913008368	dimer interface [polypeptide binding]; other site
866913008369	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
866913008370	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866913008371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
866913008372	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
866913008373	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
866913008374	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
866913008375	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
866913008376	1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374
866913008377	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
866913008378	tetrameric interface [polypeptide binding]; other site
866913008379	NAD binding site [chemical binding]; other site
866913008380	catalytic residues [active]
866913008381	substrate binding site [chemical binding]; other site
866913008382	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
866913008383	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913008384	DNA-binding site [nucleotide binding]; DNA binding site
866913008385	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913008386	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913008387	homodimer interface [polypeptide binding]; other site
866913008388	catalytic residue [active]
866913008389	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
866913008390	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
866913008391	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
866913008392	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
866913008393	Peptidase family U32; Region: Peptidase_U32; pfam01136
866913008394	Collagenase; Region: DUF3656; pfam12392
866913008395	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866913008396	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913008397	non-specific DNA binding site [nucleotide binding]; other site
866913008398	salt bridge; other site
866913008399	sequence-specific DNA binding site [nucleotide binding]; other site
866913008400	Cupin domain; Region: Cupin_2; pfam07883
866913008401	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
866913008402	benzoate transporter; Region: benE; TIGR00843
866913008403	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
866913008404	tellurite resistance protein TehB; Provisional; Region: PRK11207
866913008405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913008406	S-adenosylmethionine binding site [chemical binding]; other site
866913008407	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
866913008408	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
866913008409	gating phenylalanine in ion channel; other site
866913008410	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
866913008411	putative trimer interface [polypeptide binding]; other site
866913008412	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
866913008413	putative trimer interface [polypeptide binding]; other site
866913008414	putative CoA binding site [chemical binding]; other site
866913008415	putative CoA binding site [chemical binding]; other site
866913008416	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
866913008417	putative trimer interface [polypeptide binding]; other site
866913008418	putative CoA binding site [chemical binding]; other site
866913008419	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866913008420	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913008421	Coenzyme A binding pocket [chemical binding]; other site
866913008422	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
866913008423	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
866913008424	oligomer interface [polypeptide binding]; other site
866913008425	active site
866913008426	metal binding site [ion binding]; metal-binding site
866913008427	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
866913008428	active site
866913008429	P-loop; other site
866913008430	phosphorylation site [posttranslational modification]
866913008431	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
866913008432	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
866913008433	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
866913008434	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913008435	active site
866913008436	phosphorylation site [posttranslational modification]
866913008437	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
866913008438	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866913008439	substrate binding site [chemical binding]; other site
866913008440	hexamer interface [polypeptide binding]; other site
866913008441	metal binding site [ion binding]; metal-binding site
866913008442	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913008443	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866913008444	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913008445	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
866913008446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913008447	Coenzyme A binding pocket [chemical binding]; other site
866913008448	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
866913008449	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
866913008450	teramer interface [polypeptide binding]; other site
866913008451	active site
866913008452	FMN binding site [chemical binding]; other site
866913008453	catalytic residues [active]
866913008454	Uncharacterized conserved protein [Function unknown]; Region: COG2353
866913008455	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
866913008456	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
866913008457	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
866913008458	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
866913008459	substrate binding pocket [chemical binding]; other site
866913008460	catalytic triad [active]
866913008461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
866913008462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
866913008463	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
866913008464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913008465	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913008466	dimerization interface [polypeptide binding]; other site
866913008467	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
866913008468	dimer interface [polypeptide binding]; other site
866913008469	ligand binding site [chemical binding]; other site
866913008470	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
866913008471	HAMP domain; Region: HAMP; pfam00672
866913008472	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913008473	dimer interface [polypeptide binding]; other site
866913008474	putative CheW interface [polypeptide binding]; other site
866913008475	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
866913008476	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
866913008477	substrate binding site [chemical binding]; other site
866913008478	catalytic Zn binding site [ion binding]; other site
866913008479	NAD binding site [chemical binding]; other site
866913008480	structural Zn binding site [ion binding]; other site
866913008481	dimer interface [polypeptide binding]; other site
866913008482	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
866913008483	putative metal binding site [ion binding]; other site
866913008484	putative homodimer interface [polypeptide binding]; other site
866913008485	putative homotetramer interface [polypeptide binding]; other site
866913008486	putative homodimer-homodimer interface [polypeptide binding]; other site
866913008487	putative allosteric switch controlling residues; other site
866913008488	Sif protein; Region: Sif; cl11505
866913008489	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
866913008490	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
866913008491	active site
866913008492	catalytic triad [active]
866913008493	oxyanion hole [active]
866913008494	Predicted membrane protein [Function unknown]; Region: COG3326
866913008495	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913008496	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866913008497	substrate binding pocket [chemical binding]; other site
866913008498	membrane-bound complex binding site; other site
866913008499	hinge residues; other site
866913008500	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913008501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008502	dimer interface [polypeptide binding]; other site
866913008503	conserved gate region; other site
866913008504	putative PBP binding loops; other site
866913008505	ABC-ATPase subunit interface; other site
866913008506	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866913008507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913008508	Walker A/P-loop; other site
866913008509	ATP binding site [chemical binding]; other site
866913008510	Q-loop/lid; other site
866913008511	ABC transporter signature motif; other site
866913008512	Walker B; other site
866913008513	D-loop; other site
866913008514	H-loop/switch region; other site
866913008515	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913008516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008517	dimer interface [polypeptide binding]; other site
866913008518	conserved gate region; other site
866913008519	putative PBP binding loops; other site
866913008520	ABC-ATPase subunit interface; other site
866913008521	Predicted membrane protein [Function unknown]; Region: COG5305
866913008522	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
866913008523	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913008524	S-adenosylmethionine binding site [chemical binding]; other site
866913008525	cytochrome b561; Provisional; Region: PRK11513
866913008526	Uncharacterized conserved protein [Function unknown]; Region: COG1434
866913008527	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866913008528	putative active site [active]
866913008529	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
866913008530	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913008531	ATP binding site [chemical binding]; other site
866913008532	putative Mg++ binding site [ion binding]; other site
866913008533	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913008534	nucleotide binding region [chemical binding]; other site
866913008535	ATP-binding site [chemical binding]; other site
866913008536	Helicase associated domain (HA2); Region: HA2; pfam04408
866913008537	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
866913008538	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
866913008539	azoreductase; Reviewed; Region: PRK00170
866913008540	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866913008541	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
866913008542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
866913008543	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
866913008544	hypothetical protein; Provisional; Region: PRK10695
866913008545	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
866913008546	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
866913008547	putative ligand binding site [chemical binding]; other site
866913008548	putative NAD binding site [chemical binding]; other site
866913008549	catalytic site [active]
866913008550	heat-inducible protein; Provisional; Region: PRK10449
866913008551	Domain of unknown function (DUF333); Region: DUF333; pfam03891
866913008552	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
866913008553	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
866913008554	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
866913008555	dimer interface [polypeptide binding]; other site
866913008556	PYR/PP interface [polypeptide binding]; other site
866913008557	TPP binding site [chemical binding]; other site
866913008558	substrate binding site [chemical binding]; other site
866913008559	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
866913008560	Domain of unknown function; Region: EKR; smart00890
866913008561	4Fe-4S binding domain; Region: Fer4_6; pfam12837
866913008562	4Fe-4S binding domain; Region: Fer4; pfam00037
866913008563	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
866913008564	TPP-binding site [chemical binding]; other site
866913008565	dimer interface [polypeptide binding]; other site
866913008566	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866913008567	Ligand Binding Site [chemical binding]; other site
866913008568	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
866913008569	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866913008570	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
866913008571	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
866913008572	Ligand Binding Site [chemical binding]; other site
866913008573	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
866913008574	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866913008575	ATP binding site [chemical binding]; other site
866913008576	Mg++ binding site [ion binding]; other site
866913008577	motif III; other site
866913008578	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913008579	nucleotide binding region [chemical binding]; other site
866913008580	ATP-binding site [chemical binding]; other site
866913008581	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
866913008582	putative RNA binding site [nucleotide binding]; other site
866913008583	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
866913008584	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
866913008585	Cl binding site [ion binding]; other site
866913008586	oligomer interface [polypeptide binding]; other site
866913008587	HAMP domain; Region: HAMP; pfam00672
866913008588	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
866913008589	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913008590	dimer interface [polypeptide binding]; other site
866913008591	putative CheW interface [polypeptide binding]; other site
866913008592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
866913008593	Smr domain; Region: Smr; pfam01713
866913008594	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
866913008595	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
866913008596	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
866913008597	DNA binding site [nucleotide binding]
866913008598	active site
866913008599	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
866913008600	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866913008601	ligand binding site [chemical binding]; other site
866913008602	flexible hinge region; other site
866913008603	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
866913008604	putative switch regulator; other site
866913008605	non-specific DNA interactions [nucleotide binding]; other site
866913008606	DNA binding site [nucleotide binding]
866913008607	sequence specific DNA binding site [nucleotide binding]; other site
866913008608	putative cAMP binding site [chemical binding]; other site
866913008609	universal stress protein UspE; Provisional; Region: PRK11175
866913008610	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866913008611	Ligand Binding Site [chemical binding]; other site
866913008612	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866913008613	Ligand Binding Site [chemical binding]; other site
866913008614	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
866913008615	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866913008616	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913008617	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
866913008618	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913008619	non-specific DNA binding site [nucleotide binding]; other site
866913008620	salt bridge; other site
866913008621	sequence-specific DNA binding site [nucleotide binding]; other site
866913008622	Cupin domain; Region: Cupin_2; pfam07883
866913008623	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
866913008624	B3/4 domain; Region: B3_4; pfam03483
866913008625	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077
866913008626	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
866913008627	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913008628	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
866913008629	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
866913008630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866913008631	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913008632	oxidoreductase; Provisional; Region: PRK12742
866913008633	classical (c) SDRs; Region: SDR_c; cd05233
866913008634	NAD(P) binding site [chemical binding]; other site
866913008635	active site
866913008636	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913008637	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913008638	active site
866913008639	catalytic tetrad [active]
866913008640	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913008641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913008642	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
866913008643	putative effector binding pocket; other site
866913008644	putative dimerization interface [polypeptide binding]; other site
866913008645	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
866913008646	NmrA-like family; Region: NmrA; pfam05368
866913008647	NAD(P) binding site [chemical binding]; other site
866913008648	active site lysine
866913008649	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
866913008650	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866913008651	peptide binding site [polypeptide binding]; other site
866913008652	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
866913008653	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
866913008654	putative active site [active]
866913008655	Zn binding site [ion binding]; other site
866913008656	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
866913008657	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
866913008658	active site
866913008659	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
866913008660	dimer interface [polypeptide binding]; other site
866913008661	catalytic triad [active]
866913008662	peroxidatic and resolving cysteines [active]
866913008663	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913008664	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
866913008665	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
866913008666	putative aromatic amino acid binding site; other site
866913008667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913008668	Walker A motif; other site
866913008669	ATP binding site [chemical binding]; other site
866913008670	Walker B motif; other site
866913008671	arginine finger; other site
866913008672	hypothetical protein; Provisional; Region: PRK05415
866913008673	TIGR01620 family protein; Region: hyp_HI0043
866913008674	Predicted ATPase [General function prediction only]; Region: COG3106
866913008675	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866913008676	active site residue [active]
866913008677	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
866913008678	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
866913008679	phage shock protein C; Region: phageshock_pspC; TIGR02978
866913008680	phage shock protein B; Provisional; Region: pspB; PRK09458
866913008681	phage shock protein PspA; Provisional; Region: PRK10698
866913008682	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
866913008683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913008684	Walker A motif; other site
866913008685	ATP binding site [chemical binding]; other site
866913008686	Walker B motif; other site
866913008687	arginine finger; other site
866913008688	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
866913008689	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866913008690	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
866913008691	peptide binding site [polypeptide binding]; other site
866913008692	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
866913008693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008694	dimer interface [polypeptide binding]; other site
866913008695	conserved gate region; other site
866913008696	putative PBP binding loops; other site
866913008697	ABC-ATPase subunit interface; other site
866913008698	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
866913008699	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
866913008700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008701	dimer interface [polypeptide binding]; other site
866913008702	conserved gate region; other site
866913008703	putative PBP binding loops; other site
866913008704	ABC-ATPase subunit interface; other site
866913008705	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
866913008706	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913008707	Walker A/P-loop; other site
866913008708	ATP binding site [chemical binding]; other site
866913008709	Q-loop/lid; other site
866913008710	ABC transporter signature motif; other site
866913008711	Walker B; other site
866913008712	D-loop; other site
866913008713	H-loop/switch region; other site
866913008714	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866913008715	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
866913008716	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913008717	Walker A/P-loop; other site
866913008718	ATP binding site [chemical binding]; other site
866913008719	Q-loop/lid; other site
866913008720	ABC transporter signature motif; other site
866913008721	Walker B; other site
866913008722	D-loop; other site
866913008723	H-loop/switch region; other site
866913008724	Protein kinase domain; Region: Pkinase; pfam00069
866913008725	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
866913008726	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
866913008727	NAD binding site [chemical binding]; other site
866913008728	homotetramer interface [polypeptide binding]; other site
866913008729	homodimer interface [polypeptide binding]; other site
866913008730	substrate binding site [chemical binding]; other site
866913008731	active site
866913008732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
866913008733	Uncharacterized conserved protein [Function unknown]; Region: COG2128
866913008734	exoribonuclease II; Provisional; Region: PRK05054
866913008735	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
866913008736	RNB domain; Region: RNB; pfam00773
866913008737	S1 RNA binding domain; Region: S1; pfam00575
866913008738	RNase II stability modulator; Provisional; Region: PRK10060
866913008739	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913008740	putative active site [active]
866913008741	heme pocket [chemical binding]; other site
866913008742	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913008743	metal binding site [ion binding]; metal-binding site
866913008744	active site
866913008745	I-site; other site
866913008746	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913008747	hypothetical protein; Provisional; Region: PRK13658
866913008748	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913008749	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866913008750	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913008751	lipoprotein; Provisional; Region: PRK10540
866913008752	translation initiation factor Sui1; Validated; Region: PRK06824
866913008753	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
866913008754	putative rRNA binding site [nucleotide binding]; other site
866913008755	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
866913008756	active site
866913008757	dimer interface [polypeptide binding]; other site
866913008758	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
866913008759	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866913008760	binding surface
866913008761	TPR motif; other site
866913008762	Predicted membrane protein [Function unknown]; Region: COG3771
866913008763	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866913008764	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
866913008765	active site
866913008766	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
866913008767	dimerization interface [polypeptide binding]; other site
866913008768	active site
866913008769	aconitate hydratase; Validated; Region: PRK09277
866913008770	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
866913008771	substrate binding site [chemical binding]; other site
866913008772	ligand binding site [chemical binding]; other site
866913008773	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
866913008774	substrate binding site [chemical binding]; other site
866913008775	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
866913008776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913008777	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
866913008778	substrate binding site [chemical binding]; other site
866913008779	putative dimerization interface [polypeptide binding]; other site
866913008780	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
866913008781	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
866913008782	active site
866913008783	interdomain interaction site; other site
866913008784	putative metal-binding site [ion binding]; other site
866913008785	nucleotide binding site [chemical binding]; other site
866913008786	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
866913008787	domain I; other site
866913008788	DNA binding groove [nucleotide binding]
866913008789	phosphate binding site [ion binding]; other site
866913008790	domain II; other site
866913008791	domain III; other site
866913008792	nucleotide binding site [chemical binding]; other site
866913008793	catalytic site [active]
866913008794	domain IV; other site
866913008795	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866913008796	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866913008797	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
866913008798	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
866913008799	hypothetical protein; Provisional; Region: PRK11037
866913008800	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
866913008801	putative inner membrane peptidase; Provisional; Region: PRK11778
866913008802	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
866913008803	tandem repeat interface [polypeptide binding]; other site
866913008804	oligomer interface [polypeptide binding]; other site
866913008805	active site residues [active]
866913008806	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
866913008807	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
866913008808	NADP binding site [chemical binding]; other site
866913008809	homodimer interface [polypeptide binding]; other site
866913008810	active site
866913008811	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
866913008812	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
866913008813	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
866913008814	homodimer interface [polypeptide binding]; other site
866913008815	Walker A motif; other site
866913008816	ATP binding site [chemical binding]; other site
866913008817	hydroxycobalamin binding site [chemical binding]; other site
866913008818	Walker B motif; other site
866913008819	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
866913008820	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913008821	RNA binding surface [nucleotide binding]; other site
866913008822	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
866913008823	probable active site [active]
866913008824	hypothetical protein; Provisional; Region: PRK11630
866913008825	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
866913008826	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
866913008827	active site
866913008828	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
866913008829	anthranilate synthase component I; Provisional; Region: PRK13564
866913008830	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
866913008831	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
866913008832	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
866913008833	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
866913008834	glutamine binding [chemical binding]; other site
866913008835	catalytic triad [active]
866913008836	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
866913008837	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
866913008838	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
866913008839	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
866913008840	active site
866913008841	ribulose/triose binding site [chemical binding]; other site
866913008842	phosphate binding site [ion binding]; other site
866913008843	substrate (anthranilate) binding pocket [chemical binding]; other site
866913008844	product (indole) binding pocket [chemical binding]; other site
866913008845	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
866913008846	active site
866913008847	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
866913008848	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
866913008849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913008850	catalytic residue [active]
866913008851	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
866913008852	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
866913008853	substrate binding site [chemical binding]; other site
866913008854	active site
866913008855	catalytic residues [active]
866913008856	heterodimer interface [polypeptide binding]; other site
866913008857	General stress protein [General function prediction only]; Region: GsiB; COG3729
866913008858	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
866913008859	dimerization interface [polypeptide binding]; other site
866913008860	metal binding site [ion binding]; metal-binding site
866913008861	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
866913008862	dinuclear metal binding motif [ion binding]; other site
866913008863	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
866913008864	dimanganese center [ion binding]; other site
866913008865	outer membrane protein W; Provisional; Region: PRK10959
866913008866	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
866913008867	hypothetical protein; Provisional; Region: PRK02868
866913008868	intracellular septation protein A; Reviewed; Region: PRK00259
866913008869	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
866913008870	transport protein TonB; Provisional; Region: PRK10819
866913008871	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
866913008872	YciI-like protein; Reviewed; Region: PRK11370
866913008873	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
866913008874	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
866913008875	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
866913008876	putative active site [active]
866913008877	catalytic site [active]
866913008878	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
866913008879	putative active site [active]
866913008880	catalytic site [active]
866913008881	dsDNA-mimic protein; Reviewed; Region: PRK05094
866913008882	Ion transport protein; Region: Ion_trans; pfam00520
866913008883	Ion channel; Region: Ion_trans_2; pfam07885
866913008884	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
866913008885	Double zinc ribbon; Region: DZR; pfam12773
866913008886	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
866913008887	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913008888	Walker A/P-loop; other site
866913008889	ATP binding site [chemical binding]; other site
866913008890	Q-loop/lid; other site
866913008891	ABC transporter signature motif; other site
866913008892	Walker B; other site
866913008893	D-loop; other site
866913008894	H-loop/switch region; other site
866913008895	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
866913008896	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
866913008897	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913008898	Walker A/P-loop; other site
866913008899	ATP binding site [chemical binding]; other site
866913008900	Q-loop/lid; other site
866913008901	ABC transporter signature motif; other site
866913008902	Walker B; other site
866913008903	D-loop; other site
866913008904	H-loop/switch region; other site
866913008905	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866913008906	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
866913008907	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
866913008908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008909	dimer interface [polypeptide binding]; other site
866913008910	conserved gate region; other site
866913008911	ABC-ATPase subunit interface; other site
866913008912	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
866913008913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913008914	dimer interface [polypeptide binding]; other site
866913008915	conserved gate region; other site
866913008916	putative PBP binding loops; other site
866913008917	ABC-ATPase subunit interface; other site
866913008918	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
866913008919	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866913008920	peptide binding site [polypeptide binding]; other site
866913008921	hypothetical protein; Provisional; Region: PRK11111
866913008922	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
866913008923	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
866913008924	putative catalytic cysteine [active]
866913008925	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
866913008926	putative active site [active]
866913008927	metal binding site [ion binding]; metal-binding site
866913008928	thymidine kinase; Provisional; Region: PRK04296
866913008929	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
866913008930	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
866913008931	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
866913008932	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
866913008933	active site
866913008934	tetramer interface; other site
866913008935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913008936	active site
866913008937	response regulator of RpoS; Provisional; Region: PRK10693
866913008938	phosphorylation site [posttranslational modification]
866913008939	intermolecular recognition site; other site
866913008940	dimerization interface [polypeptide binding]; other site
866913008941	hypothetical protein; Provisional; Region: PRK10279
866913008942	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
866913008943	active site
866913008944	nucleophile elbow; other site
866913008945	hypothetical protein; Provisional; Region: PRK01617
866913008946	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
866913008947	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
866913008948	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
866913008949	putative active site [active]
866913008950	putative substrate binding site [chemical binding]; other site
866913008951	putative cosubstrate binding site; other site
866913008952	catalytic site [active]
866913008953	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913008954	Sel1-like repeats; Region: SEL1; smart00671
866913008955	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913008956	Sel1-like repeats; Region: SEL1; smart00671
866913008957	Sel1-like repeats; Region: SEL1; smart00671
866913008958	Sel1-like repeats; Region: SEL1; smart00671
866913008959	Sel1-like repeats; Region: SEL1; smart00671
866913008960	Sel1-like repeats; Region: SEL1; smart00671
866913008961	Sel1-like repeats; Region: SEL1; smart00671
866913008962	Sel1-like repeats; Region: SEL1; smart00671
866913008963	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
866913008964	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
866913008965	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
866913008966	4Fe-4S binding domain; Region: Fer4; cl02805
866913008967	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
866913008968	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
866913008969	[4Fe-4S] binding site [ion binding]; other site
866913008970	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008971	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008972	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913008973	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
866913008974	molybdopterin cofactor binding site; other site
866913008975	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
866913008976	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
866913008977	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
866913008978	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913008979	dimerization interface [polypeptide binding]; other site
866913008980	Histidine kinase; Region: HisKA_3; pfam07730
866913008981	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913008982	ATP binding site [chemical binding]; other site
866913008983	Mg2+ binding site [ion binding]; other site
866913008984	G-X-G motif; other site
866913008985	transcriptional regulator NarL; Provisional; Region: PRK10651
866913008986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913008987	active site
866913008988	phosphorylation site [posttranslational modification]
866913008989	intermolecular recognition site; other site
866913008990	dimerization interface [polypeptide binding]; other site
866913008991	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913008992	DNA binding residues [nucleotide binding]
866913008993	dimerization interface [polypeptide binding]; other site
866913008994	putative invasin; Provisional; Region: PRK10177
866913008995	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
866913008996	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
866913008997	cation transport regulator; Reviewed; Region: chaB; PRK09582
866913008998	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
866913008999	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866913009000	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
866913009001	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
866913009002	hypothetical protein; Provisional; Region: PRK10941
866913009003	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
866913009004	hypothetical protein; Provisional; Region: PRK10278
866913009005	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
866913009006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913009007	peptide chain release factor 1; Validated; Region: prfA; PRK00591
866913009008	This domain is found in peptide chain release factors; Region: PCRF; smart00937
866913009009	RF-1 domain; Region: RF-1; pfam00472
866913009010	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
866913009011	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
866913009012	tRNA; other site
866913009013	putative tRNA binding site [nucleotide binding]; other site
866913009014	putative NADP binding site [chemical binding]; other site
866913009015	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
866913009016	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
866913009017	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
866913009018	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
866913009019	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866913009020	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
866913009021	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
866913009022	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913009023	active site
866913009024	putative transporter; Provisional; Region: PRK11660
866913009025	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
866913009026	Sulfate transporter family; Region: Sulfate_transp; pfam00916
866913009027	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
866913009028	hypothetical protein; Provisional; Region: PRK10692
866913009029	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
866913009030	putative active site [active]
866913009031	catalytic residue [active]
866913009032	GTP-binding protein YchF; Reviewed; Region: PRK09601
866913009033	YchF GTPase; Region: YchF; cd01900
866913009034	G1 box; other site
866913009035	GTP/Mg2+ binding site [chemical binding]; other site
866913009036	Switch I region; other site
866913009037	G2 box; other site
866913009038	Switch II region; other site
866913009039	G3 box; other site
866913009040	G4 box; other site
866913009041	G5 box; other site
866913009042	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
866913009043	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
866913009044	Protein of unknown function (DUF4427); Region: DUF4427; pfam14468
866913009045	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
866913009046	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
866913009047	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
866913009048	hydrogenase 1 large subunit; Provisional; Region: PRK10170
866913009049	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
866913009050	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
866913009051	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
866913009052	putative substrate-binding site; other site
866913009053	nickel binding site [ion binding]; other site
866913009054	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
866913009055	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
866913009056	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
866913009057	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
866913009058	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
866913009059	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
866913009060	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
866913009061	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
866913009062	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
866913009063	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
866913009064	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
866913009065	NAD(P) binding site [chemical binding]; other site
866913009066	trehalase; Provisional; Region: treA; PRK13271
866913009067	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
866913009068	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
866913009069	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
866913009070	Flagellar regulator YcgR; Region: YcgR; pfam07317
866913009071	PilZ domain; Region: PilZ; pfam07238
866913009072	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
866913009073	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913009074	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913009075	catalytic residue [active]
866913009076	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
866913009077	dimer interface [polypeptide binding]; other site
866913009078	catalytic triad [active]
866913009079	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
866913009080	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
866913009081	TrkA-C domain; Region: TrkA_C; pfam02080
866913009082	Transporter associated domain; Region: CorC_HlyC; smart01091
866913009083	alanine racemase; Reviewed; Region: dadX; PRK03646
866913009084	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
866913009085	active site
866913009086	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866913009087	substrate binding site [chemical binding]; other site
866913009088	catalytic residues [active]
866913009089	dimer interface [polypeptide binding]; other site
866913009090	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
866913009091	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866913009092	SpoVR family protein; Provisional; Region: PRK11767
866913009093	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
866913009094	fatty acid metabolism regulator; Provisional; Region: PRK04984
866913009095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913009096	DNA-binding site [nucleotide binding]; DNA binding site
866913009097	FadR C-terminal domain; Region: FadR_C; pfam07840
866913009098	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
866913009099	transmembrane helices; other site
866913009100	disulfide bond formation protein B; Provisional; Region: PRK01749
866913009101	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
866913009102	GnsA/GnsB family; Region: GnsAB; pfam08178
866913009103	hypothetical protein; Provisional; Region: PRK05170
866913009104	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
866913009105	hypothetical protein; Provisional; Region: PRK10691
866913009106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
866913009107	septum formation inhibitor; Reviewed; Region: minC; PRK03511
866913009108	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
866913009109	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
866913009110	cell division inhibitor MinD; Provisional; Region: PRK10818
866913009111	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
866913009112	Switch I; other site
866913009113	Switch II; other site
866913009114	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
866913009115	ribonuclease D; Provisional; Region: PRK10829
866913009116	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
866913009117	catalytic site [active]
866913009118	putative active site [active]
866913009119	putative substrate binding site [chemical binding]; other site
866913009120	HRDC domain; Region: HRDC; cl02578
866913009121	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913009122	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
866913009123	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
866913009124	acyl-activating enzyme (AAE) consensus motif; other site
866913009125	putative AMP binding site [chemical binding]; other site
866913009126	putative active site [active]
866913009127	putative CoA binding site [chemical binding]; other site
866913009128	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
866913009129	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
866913009130	Glycoprotease family; Region: Peptidase_M22; pfam00814
866913009131	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
866913009132	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866913009133	DEAD_2; Region: DEAD_2; pfam06733
866913009134	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
866913009135	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
866913009136	homotrimer interaction site [polypeptide binding]; other site
866913009137	putative active site [active]
866913009138	hypothetical protein; Provisional; Region: PRK05114
866913009139	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
866913009140	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
866913009141	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
866913009142	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
866913009143	putative active site [active]
866913009144	putative CoA binding site [chemical binding]; other site
866913009145	nudix motif; other site
866913009146	metal binding site [ion binding]; metal-binding site
866913009147	L-serine deaminase; Provisional; Region: PRK15023
866913009148	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
866913009149	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
866913009150	phage resistance protein; Provisional; Region: PRK10551
866913009151	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
866913009152	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913009153	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
866913009154	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866913009155	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866913009156	Transporter associated domain; Region: CorC_HlyC; smart01091
866913009157	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
866913009158	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866913009159	active pocket/dimerization site; other site
866913009160	active site
866913009161	phosphorylation site [posttranslational modification]
866913009162	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
866913009163	active site
866913009164	phosphorylation site [posttranslational modification]
866913009165	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
866913009166	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
866913009167	hypothetical protein; Provisional; Region: PRK02913
866913009168	hypothetical protein; Provisional; Region: PRK11469
866913009169	Domain of unknown function DUF; Region: DUF204; pfam02659
866913009170	Domain of unknown function DUF; Region: DUF204; pfam02659
866913009171	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
866913009172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913009173	S-adenosylmethionine binding site [chemical binding]; other site
866913009174	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
866913009175	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866913009176	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866913009177	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866913009178	DNA-binding site [nucleotide binding]; DNA binding site
866913009179	RNA-binding motif; other site
866913009180	YebO-like protein; Region: YebO; pfam13974
866913009181	PhoPQ regulatory protein; Provisional; Region: PRK10299
866913009182	YobH-like protein; Region: YobH; pfam13996
866913009183	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
866913009184	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913009185	dimerization interface [polypeptide binding]; other site
866913009186	putative Zn2+ binding site [ion binding]; other site
866913009187	putative DNA binding site [nucleotide binding]; other site
866913009188	Bacterial transcriptional regulator; Region: IclR; pfam01614
866913009189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913009190	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913009191	putative substrate translocation pore; other site
866913009192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913009193	heat shock protein HtpX; Provisional; Region: PRK05457
866913009194	carboxy-terminal protease; Provisional; Region: PRK11186
866913009195	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
866913009196	protein binding site [polypeptide binding]; other site
866913009197	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
866913009198	Catalytic dyad [active]
866913009199	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
866913009200	ProP expression regulator; Provisional; Region: PRK04950
866913009201	ProQ/FINO family; Region: ProQ; pfam04352
866913009202	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
866913009203	GAF domain; Region: GAF_2; pfam13185
866913009204	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
866913009205	Paraquat-inducible protein A; Region: PqiA; pfam04403
866913009206	Paraquat-inducible protein A; Region: PqiA; pfam04403
866913009207	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
866913009208	mce related protein; Region: MCE; pfam02470
866913009209	mce related protein; Region: MCE; pfam02470
866913009210	mce related protein; Region: MCE; pfam02470
866913009211	mce related protein; Region: MCE; pfam02470
866913009212	mce related protein; Region: MCE; pfam02470
866913009213	mce related protein; Region: MCE; pfam02470
866913009214	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
866913009215	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
866913009216	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
866913009217	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
866913009218	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
866913009219	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
866913009220	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866913009221	type III secretion protein SopE2; Provisional; Region: PRK15280
866913009222	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
866913009223	SopE GEF domain; Region: SopE_GEF; pfam07487
866913009224	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
866913009225	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913009226	Coenzyme A binding pocket [chemical binding]; other site
866913009227	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
866913009228	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866913009229	DNA binding site [nucleotide binding]
866913009230	active site
866913009231	Int/Topo IB signature motif; other site
866913009232	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866913009233	EamA-like transporter family; Region: EamA; pfam00892
866913009234	EamA-like transporter family; Region: EamA; pfam00892
866913009235	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
866913009236	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
866913009237	ADP-ribose binding site [chemical binding]; other site
866913009238	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913009239	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
866913009240	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
866913009241	exonuclease VIII; Reviewed; Region: PRK09709
866913009242	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
866913009243	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
866913009244	dimer interface [polypeptide binding]; other site
866913009245	active site
866913009246	Int/Topo IB signature motif; other site
866913009247	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
866913009248	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
866913009249	hypothetical protein; Provisional; Region: PRK10301
866913009250	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
866913009251	Predicted amidohydrolase [General function prediction only]; Region: COG0388
866913009252	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
866913009253	exodeoxyribonuclease X; Provisional; Region: PRK07983
866913009254	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866913009255	active site
866913009256	catalytic site [active]
866913009257	substrate binding site [chemical binding]; other site
866913009258	protease 2; Provisional; Region: PRK10115
866913009259	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866913009260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
866913009261	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
866913009262	putative metal binding site [ion binding]; other site
866913009263	hypothetical protein; Provisional; Region: PRK13680
866913009264	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
866913009265	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
866913009266	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866913009267	ATP-grasp domain; Region: ATP-grasp; pfam02222
866913009268	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
866913009269	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
866913009270	active site
866913009271	intersubunit interface [polypeptide binding]; other site
866913009272	catalytic residue [active]
866913009273	phosphogluconate dehydratase; Validated; Region: PRK09054
866913009274	6-phosphogluconate dehydratase; Region: edd; TIGR01196
866913009275	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
866913009276	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
866913009277	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
866913009278	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
866913009279	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866913009280	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866913009281	putative active site [active]
866913009282	pyruvate kinase; Provisional; Region: PRK05826
866913009283	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
866913009284	domain interfaces; other site
866913009285	active site
866913009286	putative peptidase; Provisional; Region: PRK11649
866913009287	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
866913009288	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913009289	Peptidase family M23; Region: Peptidase_M23; pfam01551
866913009290	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
866913009291	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
866913009292	metal binding site [ion binding]; metal-binding site
866913009293	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
866913009294	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
866913009295	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
866913009296	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913009297	ABC-ATPase subunit  interface; other site
866913009298	dimer interface [polypeptide binding]; other site
866913009299	putative PBP binding regions; other site
866913009300	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
866913009301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913009302	Walker A motif; other site
866913009303	ATP binding site [chemical binding]; other site
866913009304	Walker B motif; other site
866913009305	arginine finger; other site
866913009306	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
866913009307	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
866913009308	RuvA N terminal domain; Region: RuvA_N; pfam01330
866913009309	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
866913009310	hypothetical protein; Provisional; Region: PRK11470
866913009311	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
866913009312	active site
866913009313	putative DNA-binding cleft [nucleotide binding]; other site
866913009314	dimer interface [polypeptide binding]; other site
866913009315	hypothetical protein; Validated; Region: PRK00110
866913009316	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
866913009317	nudix motif; other site
866913009318	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
866913009319	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
866913009320	dimer interface [polypeptide binding]; other site
866913009321	anticodon binding site; other site
866913009322	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
866913009323	homodimer interface [polypeptide binding]; other site
866913009324	motif 1; other site
866913009325	active site
866913009326	motif 2; other site
866913009327	GAD domain; Region: GAD; pfam02938
866913009328	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866913009329	active site
866913009330	motif 3; other site
866913009331	Isochorismatase family; Region: Isochorismatase; pfam00857
866913009332	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
866913009333	catalytic triad [active]
866913009334	conserved cis-peptide bond; other site
866913009335	hypothetical protein; Provisional; Region: PRK10302
866913009336	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
866913009337	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913009338	S-adenosylmethionine binding site [chemical binding]; other site
866913009339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913009340	S-adenosylmethionine binding site [chemical binding]; other site
866913009341	copper homeostasis protein CutC; Provisional; Region: PRK11572
866913009342	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
866913009343	putative metal binding site [ion binding]; other site
866913009344	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
866913009345	arginyl-tRNA synthetase; Region: argS; TIGR00456
866913009346	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
866913009347	active site
866913009348	HIGH motif; other site
866913009349	KMSK motif region; other site
866913009350	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
866913009351	tRNA binding surface [nucleotide binding]; other site
866913009352	anticodon binding site; other site
866913009353	penicillin-binding protein 2; Provisional; Region: PRK10795
866913009354	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866913009355	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866913009356	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
866913009357	Flagellar protein FlhE; Region: FlhE; pfam06366
866913009358	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
866913009359	FHIPEP family; Region: FHIPEP; pfam00771
866913009360	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
866913009361	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
866913009362	chemotaxis regulator CheZ; Provisional; Region: PRK11166
866913009363	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
866913009364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913009365	active site
866913009366	phosphorylation site [posttranslational modification]
866913009367	intermolecular recognition site; other site
866913009368	dimerization interface [polypeptide binding]; other site
866913009369	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
866913009370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913009371	active site
866913009372	phosphorylation site [posttranslational modification]
866913009373	intermolecular recognition site; other site
866913009374	dimerization interface [polypeptide binding]; other site
866913009375	CheB methylesterase; Region: CheB_methylest; pfam01339
866913009376	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
866913009377	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
866913009378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913009379	S-adenosylmethionine binding site [chemical binding]; other site
866913009380	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
866913009381	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
866913009382	dimer interface [polypeptide binding]; other site
866913009383	ligand binding site [chemical binding]; other site
866913009384	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913009385	dimerization interface [polypeptide binding]; other site
866913009386	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913009387	dimer interface [polypeptide binding]; other site
866913009388	putative CheW interface [polypeptide binding]; other site
866913009389	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
866913009390	putative CheA interaction surface; other site
866913009391	chemotaxis protein CheA; Provisional; Region: PRK10547
866913009392	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
866913009393	putative binding surface; other site
866913009394	active site
866913009395	CheY binding; Region: CheY-binding; pfam09078
866913009396	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
866913009397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913009398	ATP binding site [chemical binding]; other site
866913009399	Mg2+ binding site [ion binding]; other site
866913009400	G-X-G motif; other site
866913009401	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
866913009402	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
866913009403	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
866913009404	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
866913009405	ligand binding site [chemical binding]; other site
866913009406	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
866913009407	flagellar motor protein MotA; Validated; Region: PRK09110
866913009408	transcriptional activator FlhC; Provisional; Region: PRK12722
866913009409	transcriptional activator FlhD; Provisional; Region: PRK02909
866913009410	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866913009411	Ligand Binding Site [chemical binding]; other site
866913009412	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
866913009413	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
866913009414	active site
866913009415	homotetramer interface [polypeptide binding]; other site
866913009416	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
866913009417	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
866913009418	DJ-1 family protein; Region: not_thiJ; TIGR01383
866913009419	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
866913009420	conserved cys residue [active]
866913009421	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
866913009422	Ferritin-like domain; Region: Ferritin; pfam00210
866913009423	ferroxidase diiron center [ion binding]; other site
866913009424	hypothetical protein; Provisional; Region: PRK09273
866913009425	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
866913009426	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
866913009427	YecR-like lipoprotein; Region: YecR; pfam13992
866913009428	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
866913009429	Ferritin-like domain; Region: Ferritin; pfam00210
866913009430	ferroxidase diiron center [ion binding]; other site
866913009431	probable metal-binding protein; Region: matur_matur; TIGR03853
866913009432	tyrosine transporter TyrP; Provisional; Region: PRK15132
866913009433	aromatic amino acid transport protein; Region: araaP; TIGR00837
866913009434	hypothetical protein; Provisional; Region: PRK10396
866913009435	yecA family protein; Region: ygfB_yecA; TIGR02292
866913009436	SEC-C motif; Region: SEC-C; pfam02810
866913009437	glucose-6-phosphate 1-dehydrogenase; Region: PLN02640
866913009438	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
866913009439	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
866913009440	NlpC/P60 family; Region: NLPC_P60; cl17555
866913009441	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
866913009442	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
866913009443	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
866913009444	GIY-YIG motif/motif A; other site
866913009445	active site
866913009446	catalytic site [active]
866913009447	putative DNA binding site [nucleotide binding]; other site
866913009448	metal binding site [ion binding]; metal-binding site
866913009449	UvrB/uvrC motif; Region: UVR; pfam02151
866913009450	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
866913009451	Helix-hairpin-helix motif; Region: HHH; pfam00633
866913009452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913009453	active site
866913009454	phosphorylation site [posttranslational modification]
866913009455	intermolecular recognition site; other site
866913009456	dimerization interface [polypeptide binding]; other site
866913009457	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913009458	DNA binding residues [nucleotide binding]
866913009459	dimerization interface [polypeptide binding]; other site
866913009460	Autoinducer binding domain; Region: Autoind_bind; pfam03472
866913009461	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
866913009462	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866913009463	Walker A/P-loop; other site
866913009464	ATP binding site [chemical binding]; other site
866913009465	Q-loop/lid; other site
866913009466	ABC transporter signature motif; other site
866913009467	Walker B; other site
866913009468	D-loop; other site
866913009469	H-loop/switch region; other site
866913009470	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866913009471	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913009472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913009473	dimer interface [polypeptide binding]; other site
866913009474	conserved gate region; other site
866913009475	putative PBP binding loops; other site
866913009476	ABC-ATPase subunit interface; other site
866913009477	D-cysteine desulfhydrase; Validated; Region: PRK03910
866913009478	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
866913009479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913009480	catalytic residue [active]
866913009481	cystine transporter subunit; Provisional; Region: PRK11260
866913009482	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913009483	substrate binding pocket [chemical binding]; other site
866913009484	membrane-bound complex binding site; other site
866913009485	hinge residues; other site
866913009486	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
866913009487	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
866913009488	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866913009489	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866913009490	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866913009491	DNA binding residues [nucleotide binding]
866913009492	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913009493	flagellin; Validated; Region: PRK08026
866913009494	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
866913009495	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
866913009496	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
866913009497	flagellar capping protein; Reviewed; Region: fliD; PRK08032
866913009498	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
866913009499	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
866913009500	flagellar protein FliS; Validated; Region: fliS; PRK05685
866913009501	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
866913009502	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
866913009503	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
866913009504	active site
866913009505	Na/Ca binding site [ion binding]; other site
866913009506	catalytic site [active]
866913009507	lipoprotein; Provisional; Region: PRK10397
866913009508	putative inner membrane protein; Provisional; Region: PRK11099
866913009509	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
866913009510	CPxP  motif; other site
866913009511	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
866913009512	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
866913009513	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
866913009514	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
866913009515	flagellar motor switch protein FliG; Region: fliG; TIGR00207
866913009516	FliG C-terminal domain; Region: FliG_C; pfam01706
866913009517	flagellar assembly protein H; Validated; Region: fliH; PRK05687
866913009518	Flagellar assembly protein FliH; Region: FliH; pfam02108
866913009519	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
866913009520	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
866913009521	Walker A motif/ATP binding site; other site
866913009522	Walker B motif; other site
866913009523	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
866913009524	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
866913009525	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
866913009526	flagellar hook-length control protein; Provisional; Region: PRK10118
866913009527	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
866913009528	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
866913009529	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
866913009530	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
866913009531	flagellar motor switch protein; Validated; Region: fliN; PRK05698
866913009532	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
866913009533	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
866913009534	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
866913009535	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
866913009536	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
866913009537	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913009538	DNA binding residues [nucleotide binding]
866913009539	dimerization interface [polypeptide binding]; other site
866913009540	hypothetical protein; Provisional; Region: PRK10708
866913009541	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
866913009542	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
866913009543	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913009544	active site
866913009545	motif I; other site
866913009546	motif II; other site
866913009547	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
866913009548	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913009549	metal binding site [ion binding]; metal-binding site
866913009550	active site
866913009551	I-site; other site
866913009552	Uncharacterized small protein [Function unknown]; Region: COG5475
866913009553	hypothetical protein; Provisional; Region: PRK10062
866913009554	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
866913009555	EamA-like transporter family; Region: EamA; pfam00892
866913009556	EamA-like transporter family; Region: EamA; pfam00892
866913009557	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
866913009558	additional DNA contacts [nucleotide binding]; other site
866913009559	mismatch recognition site; other site
866913009560	active site
866913009561	zinc binding site [ion binding]; other site
866913009562	DNA intercalation site [nucleotide binding]; other site
866913009563	DNA cytosine methylase; Provisional; Region: PRK10458
866913009564	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
866913009565	cofactor binding site; other site
866913009566	DNA binding site [nucleotide binding]
866913009567	substrate interaction site [chemical binding]; other site
866913009568	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
866913009569	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866913009570	Zn2+ binding site [ion binding]; other site
866913009571	Mg2+ binding site [ion binding]; other site
866913009572	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913009573	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
866913009574	trimer interface [polypeptide binding]; other site
866913009575	eyelet of channel; other site
866913009576	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866913009577	DNA-binding site [nucleotide binding]; DNA binding site
866913009578	RNA-binding motif; other site
866913009579	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
866913009580	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
866913009581	active site
866913009582	DNA binding site [nucleotide binding]
866913009583	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
866913009584	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
866913009585	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
866913009586	Catalytic site [active]
866913009587	type III secretion system protein; Provisional; Region: PRK15384; cl14665
866913009588	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
866913009589	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913009590	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
866913009591	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
866913009592	Phage protein GP46; Region: GP46; pfam07409
866913009593	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
866913009594	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
866913009595	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
866913009596	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
866913009597	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
866913009598	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
866913009599	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
866913009600	Phage tail tube protein; Region: Tail_tube; pfam10618
866913009601	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
866913009602	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
866913009603	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
866913009604	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
866913009605	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
866913009606	oligomerization interface [polypeptide binding]; other site
866913009607	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
866913009608	Phage capsid family; Region: Phage_capsid; pfam05065
866913009609	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
866913009610	Phage-related protein [Function unknown]; Region: COG4695
866913009611	Phage portal protein; Region: Phage_portal; pfam04860
866913009612	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
866913009613	Phage terminase, small subunit; Region: Terminase_4; pfam05119
866913009614	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
866913009615	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
866913009616	active site
866913009617	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
866913009618	Predicted chitinase [General function prediction only]; Region: COG3179
866913009619	catalytic residue [active]
866913009620	Protein of unknown function (DUF968); Region: DUF968; pfam06147
866913009621	KilA-N domain; Region: KilA-N; pfam04383
866913009622	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
866913009623	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
866913009624	PerC transcriptional activator; Region: PerC; pfam06069
866913009625	Helix-turn-helix domain; Region: HTH_36; pfam13730
866913009626	Ash protein family; Region: Phage_ASH; pfam10554
866913009627	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
866913009628	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913009629	non-specific DNA binding site [nucleotide binding]; other site
866913009630	salt bridge; other site
866913009631	sequence-specific DNA binding site [nucleotide binding]; other site
866913009632	Predicted transcriptional regulator [Transcription]; Region: COG2932
866913009633	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913009634	non-specific DNA binding site [nucleotide binding]; other site
866913009635	salt bridge; other site
866913009636	sequence-specific DNA binding site [nucleotide binding]; other site
866913009637	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
866913009638	Catalytic site [active]
866913009639	Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065
866913009640	HD domain; Region: HD_3; cl17350
866913009641	Protein of unknown function DUF262; Region: DUF262; pfam03235
866913009642	Uncharacterized conserved protein [Function unknown]; Region: COG1479
866913009643	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
866913009644	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
866913009645	active site
866913009646	catalytic site [active]
866913009647	substrate binding site [chemical binding]; other site
866913009648	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
866913009649	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866913009650	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
866913009651	dimer interface [polypeptide binding]; other site
866913009652	active site
866913009653	Int/Topo IB signature motif; other site
866913009654	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
866913009655	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
866913009656	putative protease; Region: PHA00666
866913009657	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
866913009658	Integrase; Region: Integrase_1; pfam12835
866913009659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
866913009660	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
866913009661	Sel1 repeat; Region: Sel1; pfam08238
866913009662	Sel1-like repeats; Region: SEL1; smart00671
866913009663	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
866913009664	AMP nucleosidase; Provisional; Region: PRK08292
866913009665	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
866913009666	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
866913009667	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
866913009668	MATE family multidrug exporter; Provisional; Region: PRK10189
866913009669	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
866913009670	L,D-transpeptidase; Provisional; Region: PRK10190
866913009671	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866913009672	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
866913009673	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
866913009674	putative dimer interface [polypeptide binding]; other site
866913009675	active site pocket [active]
866913009676	putative cataytic base [active]
866913009677	cobalamin synthase; Reviewed; Region: cobS; PRK00235
866913009678	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
866913009679	homotrimer interface [polypeptide binding]; other site
866913009680	Walker A motif; other site
866913009681	GTP binding site [chemical binding]; other site
866913009682	Walker B motif; other site
866913009683	cobyric acid synthase; Provisional; Region: PRK00784
866913009684	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
866913009685	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
866913009686	catalytic triad [active]
866913009687	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
866913009688	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866913009689	Walker A/P-loop; other site
866913009690	ATP binding site [chemical binding]; other site
866913009691	Q-loop/lid; other site
866913009692	ABC transporter signature motif; other site
866913009693	Walker B; other site
866913009694	D-loop; other site
866913009695	H-loop/switch region; other site
866913009696	cobalt transport protein CbiQ; Provisional; Region: PRK15485
866913009697	cobalt transport protein CbiN; Provisional; Region: PRK02898
866913009698	cobalt transport protein CbiM; Validated; Region: PRK08319
866913009699	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
866913009700	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
866913009701	active site
866913009702	SAM binding site [chemical binding]; other site
866913009703	homodimer interface [polypeptide binding]; other site
866913009704	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
866913009705	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
866913009706	active site
866913009707	C-terminal domain interface [polypeptide binding]; other site
866913009708	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
866913009709	active site
866913009710	N-terminal domain interface [polypeptide binding]; other site
866913009711	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
866913009712	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
866913009713	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
866913009714	active site
866913009715	SAM binding site [chemical binding]; other site
866913009716	homodimer interface [polypeptide binding]; other site
866913009717	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
866913009718	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
866913009719	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
866913009720	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
866913009721	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
866913009722	active site
866913009723	SAM binding site [chemical binding]; other site
866913009724	homodimer interface [polypeptide binding]; other site
866913009725	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
866913009726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913009727	S-adenosylmethionine binding site [chemical binding]; other site
866913009728	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
866913009729	active site
866913009730	putative homodimer interface [polypeptide binding]; other site
866913009731	SAM binding site [chemical binding]; other site
866913009732	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
866913009733	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
866913009734	Precorrin-8X methylmutase; Region: CbiC; pfam02570
866913009735	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
866913009736	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
866913009737	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
866913009738	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
866913009739	catalytic triad [active]
866913009740	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
866913009741	Sensory domain found in PocR; Region: PocR; pfam10114
866913009742	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913009743	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913009744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913009745	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
866913009746	amphipathic channel; other site
866913009747	Asn-Pro-Ala signature motifs; other site
866913009748	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
866913009749	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
866913009750	Hexamer interface [polypeptide binding]; other site
866913009751	Putative hexagonal pore residue; other site
866913009752	propanediol utilization protein PduB; Provisional; Region: PRK15415
866913009753	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
866913009754	putative hexamer interface [polypeptide binding]; other site
866913009755	putative hexagonal pore; other site
866913009756	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
866913009757	putative hexamer interface [polypeptide binding]; other site
866913009758	putative hexagonal pore; other site
866913009759	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
866913009760	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
866913009761	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
866913009762	alpha-beta subunit interface [polypeptide binding]; other site
866913009763	alpha-gamma subunit interface [polypeptide binding]; other site
866913009764	active site
866913009765	substrate and K+ binding site; other site
866913009766	K+ binding site [ion binding]; other site
866913009767	cobalamin binding site [chemical binding]; other site
866913009768	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
866913009769	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
866913009770	Cell division protein FtsA; Region: FtsA; cl17206
866913009771	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
866913009772	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
866913009773	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
866913009774	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
866913009775	Hexamer interface [polypeptide binding]; other site
866913009776	Putative hexagonal pore residue; other site
866913009777	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
866913009778	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
866913009779	putative hexamer interface [polypeptide binding]; other site
866913009780	putative hexagonal pore; other site
866913009781	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
866913009782	Propanediol utilisation protein PduL; Region: PduL; pfam06130
866913009783	Propanediol utilisation protein PduL; Region: PduL; pfam06130
866913009784	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
866913009785	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
866913009786	Hexamer/Pentamer interface [polypeptide binding]; other site
866913009787	central pore; other site
866913009788	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
866913009789	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
866913009790	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
866913009791	putative catalytic cysteine [active]
866913009792	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
866913009793	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
866913009794	putative active site [active]
866913009795	metal binding site [ion binding]; metal-binding site
866913009796	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
866913009797	SLBB domain; Region: SLBB; pfam10531
866913009798	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
866913009799	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
866913009800	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
866913009801	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
866913009802	putative hexamer interface [polypeptide binding]; other site
866913009803	putative hexagonal pore; other site
866913009804	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
866913009805	putative hexamer interface [polypeptide binding]; other site
866913009806	putative hexagonal pore; other site
866913009807	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
866913009808	putative hexamer interface [polypeptide binding]; other site
866913009809	putative hexagonal pore; other site
866913009810	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
866913009811	G3 box; other site
866913009812	Switch II region; other site
866913009813	GTP/Mg2+ binding site [chemical binding]; other site
866913009814	G4 box; other site
866913009815	G5 box; other site
866913009816	propionate kinase; Reviewed; Region: PRK12397
866913009817	propionate/acetate kinase; Provisional; Region: PRK12379
866913009818	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
866913009819	hypothetical protein; Provisional; Region: PRK05423
866913009820	Predicted membrane protein [Function unknown]; Region: COG1289
866913009821	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
866913009822	DNA gyrase inhibitor; Provisional; Region: PRK10016
866913009823	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
866913009824	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866913009825	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
866913009826	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
866913009827	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
866913009828	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
866913009829	4Fe-4S binding domain; Region: Fer4; cl02805
866913009830	thiosulfate reductase PhsA; Provisional; Region: PRK15488
866913009831	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
866913009832	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
866913009833	putative [Fe4-S4] binding site [ion binding]; other site
866913009834	putative molybdopterin cofactor binding site [chemical binding]; other site
866913009835	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
866913009836	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
866913009837	putative molybdopterin cofactor binding site; other site
866913009838	E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377
866913009839	SopA-like central domain; Region: SopA; pfam13981
866913009840	SopA-like catalytic domain; Region: SopA_C; pfam13979
866913009841	exonuclease I; Provisional; Region: sbcB; PRK11779
866913009842	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
866913009843	active site
866913009844	catalytic site [active]
866913009845	substrate binding site [chemical binding]; other site
866913009846	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
866913009847	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
866913009848	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913009849	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
866913009850	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913009851	dimerization interface [polypeptide binding]; other site
866913009852	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866913009853	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
866913009854	putative NAD(P) binding site [chemical binding]; other site
866913009855	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
866913009856	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
866913009857	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
866913009858	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
866913009859	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
866913009860	NAD binding site [chemical binding]; other site
866913009861	dimerization interface [polypeptide binding]; other site
866913009862	product binding site; other site
866913009863	substrate binding site [chemical binding]; other site
866913009864	zinc binding site [ion binding]; other site
866913009865	catalytic residues [active]
866913009866	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
866913009867	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913009868	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913009869	homodimer interface [polypeptide binding]; other site
866913009870	catalytic residue [active]
866913009871	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
866913009872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913009873	active site
866913009874	motif I; other site
866913009875	motif II; other site
866913009876	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
866913009877	putative active site pocket [active]
866913009878	4-fold oligomerization interface [polypeptide binding]; other site
866913009879	metal binding residues [ion binding]; metal-binding site
866913009880	3-fold/trimer interface [polypeptide binding]; other site
866913009881	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
866913009882	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
866913009883	putative active site [active]
866913009884	oxyanion strand; other site
866913009885	catalytic triad [active]
866913009886	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
866913009887	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
866913009888	catalytic residues [active]
866913009889	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
866913009890	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
866913009891	substrate binding site [chemical binding]; other site
866913009892	glutamase interaction surface [polypeptide binding]; other site
866913009893	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
866913009894	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
866913009895	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
866913009896	metal binding site [ion binding]; metal-binding site
866913009897	chain length determinant protein WzzB; Provisional; Region: PRK15471
866913009898	Chain length determinant protein; Region: Wzz; pfam02706
866913009899	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
866913009900	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
866913009901	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
866913009902	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
866913009903	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
866913009904	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866913009905	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
866913009906	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
866913009907	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
866913009908	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
866913009909	Bacterial sugar transferase; Region: Bac_transf; pfam02397
866913009910	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
866913009911	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
866913009912	active site
866913009913	substrate binding site [chemical binding]; other site
866913009914	metal binding site [ion binding]; metal-binding site
866913009915	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
866913009916	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
866913009917	Substrate binding site; other site
866913009918	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
866913009919	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866913009920	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
866913009921	active site
866913009922	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866913009923	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
866913009924	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866913009925	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866913009926	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
866913009927	active site
866913009928	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
866913009929	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866913009930	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
866913009931	NAD(P) binding site [chemical binding]; other site
866913009932	active site
866913009933	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
866913009934	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
866913009935	inhibitor-cofactor binding pocket; inhibition site
866913009936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913009937	catalytic residue [active]
866913009938	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
866913009939	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
866913009940	NAD binding site [chemical binding]; other site
866913009941	homotetramer interface [polypeptide binding]; other site
866913009942	homodimer interface [polypeptide binding]; other site
866913009943	substrate binding site [chemical binding]; other site
866913009944	active site
866913009945	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
866913009946	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
866913009947	substrate binding site; other site
866913009948	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
866913009949	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
866913009950	catalytic loop [active]
866913009951	iron binding site [ion binding]; other site
866913009952	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
866913009953	FAD binding pocket [chemical binding]; other site
866913009954	FAD binding motif [chemical binding]; other site
866913009955	phosphate binding motif [ion binding]; other site
866913009956	beta-alpha-beta structure motif; other site
866913009957	NAD binding pocket [chemical binding]; other site
866913009958	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
866913009959	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
866913009960	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
866913009961	substrate binding site; other site
866913009962	tetramer interface; other site
866913009963	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
866913009964	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
866913009965	NADP binding site [chemical binding]; other site
866913009966	active site
866913009967	putative substrate binding site [chemical binding]; other site
866913009968	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
866913009969	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
866913009970	NAD binding site [chemical binding]; other site
866913009971	substrate binding site [chemical binding]; other site
866913009972	homodimer interface [polypeptide binding]; other site
866913009973	active site
866913009974	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
866913009975	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
866913009976	active site
866913009977	tetramer interface; other site
866913009978	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
866913009979	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
866913009980	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
866913009981	putative ADP-binding pocket [chemical binding]; other site
866913009982	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
866913009983	colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006
866913009984	colanic acid exporter; Provisional; Region: PRK10459
866913009985	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
866913009986	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
866913009987	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
866913009988	phosphomannomutase CpsG; Provisional; Region: PRK15414
866913009989	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
866913009990	active site
866913009991	substrate binding site [chemical binding]; other site
866913009992	metal binding site [ion binding]; metal-binding site
866913009993	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
866913009994	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
866913009995	Substrate binding site; other site
866913009996	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
866913009997	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
866913009998	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
866913009999	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
866913010000	active site
866913010001	GDP-Mannose binding site [chemical binding]; other site
866913010002	dimer interface [polypeptide binding]; other site
866913010003	modified nudix motif
866913010004	metal binding site [ion binding]; metal-binding site
866913010005	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
866913010006	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
866913010007	NADP binding site [chemical binding]; other site
866913010008	active site
866913010009	putative substrate binding site [chemical binding]; other site
866913010010	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
866913010011	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
866913010012	NADP-binding site; other site
866913010013	homotetramer interface [polypeptide binding]; other site
866913010014	substrate binding site [chemical binding]; other site
866913010015	homodimer interface [polypeptide binding]; other site
866913010016	active site
866913010017	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
866913010018	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
866913010019	putative trimer interface [polypeptide binding]; other site
866913010020	putative active site [active]
866913010021	putative substrate binding site [chemical binding]; other site
866913010022	putative CoA binding site [chemical binding]; other site
866913010023	putative glycosyl transferase; Provisional; Region: PRK10063
866913010024	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
866913010025	metal-binding site
866913010026	putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075
866913010027	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
866913010028	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866913010029	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866913010030	putative acyl transferase; Provisional; Region: PRK10191
866913010031	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
866913010032	trimer interface [polypeptide binding]; other site
866913010033	active site
866913010034	substrate binding site [chemical binding]; other site
866913010035	CoA binding site [chemical binding]; other site
866913010036	putative glycosyl transferase; Provisional; Region: PRK10018
866913010037	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
866913010038	active site
866913010039	tyrosine kinase; Provisional; Region: PRK11519
866913010040	Chain length determinant protein; Region: Wzz; pfam02706
866913010041	Chain length determinant protein; Region: Wzz; cl15801
866913010042	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
866913010043	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866913010044	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866913010045	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
866913010046	active site
866913010047	polysaccharide export protein Wza; Provisional; Region: PRK15078
866913010048	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
866913010049	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
866913010050	FOG: CBS domain [General function prediction only]; Region: COG0517
866913010051	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866913010052	Transporter associated domain; Region: CorC_HlyC; smart01091
866913010053	putative assembly protein; Provisional; Region: PRK10833
866913010054	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
866913010055	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
866913010056	trimer interface [polypeptide binding]; other site
866913010057	active site
866913010058	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
866913010059	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
866913010060	ATP-binding site [chemical binding]; other site
866913010061	Sugar specificity; other site
866913010062	Pyrimidine base specificity; other site
866913010063	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
866913010064	PAS domain S-box; Region: sensory_box; TIGR00229
866913010065	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913010066	putative active site [active]
866913010067	heme pocket [chemical binding]; other site
866913010068	PAS domain S-box; Region: sensory_box; TIGR00229
866913010069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913010070	putative active site [active]
866913010071	heme pocket [chemical binding]; other site
866913010072	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866913010073	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913010074	metal binding site [ion binding]; metal-binding site
866913010075	active site
866913010076	I-site; other site
866913010077	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913010078	AlkA N-terminal domain; Region: AlkA_N; pfam06029
866913010079	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866913010080	minor groove reading motif; other site
866913010081	helix-hairpin-helix signature motif; other site
866913010082	active site
866913010083	putative chaperone; Provisional; Region: PRK11678
866913010084	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
866913010085	nucleotide binding site [chemical binding]; other site
866913010086	putative NEF/HSP70 interaction site [polypeptide binding]; other site
866913010087	SBD interface [polypeptide binding]; other site
866913010088	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
866913010089	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913010090	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913010091	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
866913010092	Protein export membrane protein; Region: SecD_SecF; cl14618
866913010093	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
866913010094	putative transporter; Provisional; Region: PRK10504
866913010095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010096	putative substrate translocation pore; other site
866913010097	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
866913010098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913010099	dimerization interface [polypeptide binding]; other site
866913010100	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913010101	dimer interface [polypeptide binding]; other site
866913010102	phosphorylation site [posttranslational modification]
866913010103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913010104	ATP binding site [chemical binding]; other site
866913010105	Mg2+ binding site [ion binding]; other site
866913010106	G-X-G motif; other site
866913010107	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
866913010108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913010109	active site
866913010110	phosphorylation site [posttranslational modification]
866913010111	intermolecular recognition site; other site
866913010112	dimerization interface [polypeptide binding]; other site
866913010113	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913010114	DNA binding site [nucleotide binding]
866913010115	PcfJ-like protein; Region: PcfJ; pfam14284
866913010116	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
866913010117	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
866913010118	putative protease; Provisional; Region: PRK15452
866913010119	Peptidase family U32; Region: Peptidase_U32; pfam01136
866913010120	type III secretion system protein; Provisional; Region: PRK15384; cl14665
866913010121	lipid kinase; Reviewed; Region: PRK13054
866913010122	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866913010123	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
866913010124	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
866913010125	putative active site; other site
866913010126	catalytic residue [active]
866913010127	nucleoside transporter; Region: 2A0110; TIGR00889
866913010128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010129	putative substrate translocation pore; other site
866913010130	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
866913010131	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913010132	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
866913010133	substrate binding site [chemical binding]; other site
866913010134	ATP binding site [chemical binding]; other site
866913010135	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866913010136	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913010137	DNA-binding site [nucleotide binding]; DNA binding site
866913010138	UTRA domain; Region: UTRA; pfam07702
866913010139	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
866913010140	dimer interface [polypeptide binding]; other site
866913010141	substrate binding site [chemical binding]; other site
866913010142	ATP binding site [chemical binding]; other site
866913010143	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
866913010144	substrate binding site [chemical binding]; other site
866913010145	multimerization interface [polypeptide binding]; other site
866913010146	ATP binding site [chemical binding]; other site
866913010147	Predicted integral membrane protein [Function unknown]; Region: COG5455
866913010148	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
866913010149	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
866913010150	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
866913010151	PapC N-terminal domain; Region: PapC_N; pfam13954
866913010152	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913010153	PapC C-terminal domain; Region: PapC_C; pfam13953
866913010154	fimbrial chaperone protein PegB; Provisional; Region: PRK15218
866913010155	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913010156	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913010157	fimbrial chaperone protein; Provisional; Region: PRK15220
866913010158	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
866913010159	antiporter inner membrane protein; Provisional; Region: PRK11670
866913010160	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
866913010161	Walker A motif; other site
866913010162	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
866913010163	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
866913010164	active site
866913010165	HIGH motif; other site
866913010166	KMSKS motif; other site
866913010167	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
866913010168	tRNA binding surface [nucleotide binding]; other site
866913010169	anticodon binding site; other site
866913010170	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
866913010171	dimer interface [polypeptide binding]; other site
866913010172	putative tRNA-binding site [nucleotide binding]; other site
866913010173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
866913010174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
866913010175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
866913010176	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
866913010177	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
866913010178	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
866913010179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913010180	active site
866913010181	phosphorylation site [posttranslational modification]
866913010182	intermolecular recognition site; other site
866913010183	dimerization interface [polypeptide binding]; other site
866913010184	LytTr DNA-binding domain; Region: LytTR; pfam04397
866913010185	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
866913010186	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
866913010187	GAF domain; Region: GAF; pfam01590
866913010188	Histidine kinase; Region: His_kinase; pfam06580
866913010189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913010190	ATP binding site [chemical binding]; other site
866913010191	Mg2+ binding site [ion binding]; other site
866913010192	G-X-G motif; other site
866913010193	transcriptional regulator MirA; Provisional; Region: PRK15043
866913010194	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
866913010195	DNA binding residues [nucleotide binding]
866913010196	hypothetical protein; Provisional; Region: PRK13681
866913010197	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
866913010198	putative PBP binding loops; other site
866913010199	ABC-ATPase subunit interface; other site
866913010200	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
866913010201	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
866913010202	Walker A/P-loop; other site
866913010203	ATP binding site [chemical binding]; other site
866913010204	Q-loop/lid; other site
866913010205	ABC transporter signature motif; other site
866913010206	Walker B; other site
866913010207	D-loop; other site
866913010208	H-loop/switch region; other site
866913010209	CBS domain; Region: CBS; pfam00571
866913010210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913010211	dimer interface [polypeptide binding]; other site
866913010212	conserved gate region; other site
866913010213	ABC-ATPase subunit interface; other site
866913010214	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
866913010215	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
866913010216	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
866913010217	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
866913010218	D-lactate dehydrogenase; Provisional; Region: PRK11183
866913010219	FAD binding domain; Region: FAD_binding_4; pfam01565
866913010220	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
866913010221	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
866913010222	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
866913010223	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
866913010224	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866913010225	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866913010226	oxidoreductase; Provisional; Region: PRK12743
866913010227	classical (c) SDRs; Region: SDR_c; cd05233
866913010228	NAD(P) binding site [chemical binding]; other site
866913010229	active site
866913010230	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
866913010231	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
866913010232	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
866913010233	FMN binding site [chemical binding]; other site
866913010234	active site
866913010235	catalytic residues [active]
866913010236	substrate binding site [chemical binding]; other site
866913010237	salicylate hydroxylase; Provisional; Region: PRK08163
866913010238	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866913010239	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
866913010240	maleylacetoacetate isomerase; Region: maiA; TIGR01262
866913010241	C-terminal domain interface [polypeptide binding]; other site
866913010242	GSH binding site (G-site) [chemical binding]; other site
866913010243	putative dimer interface [polypeptide binding]; other site
866913010244	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
866913010245	dimer interface [polypeptide binding]; other site
866913010246	N-terminal domain interface [polypeptide binding]; other site
866913010247	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
866913010248	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
866913010249	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
866913010250	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
866913010251	Cupin domain; Region: Cupin_2; pfam07883
866913010252	Cupin domain; Region: Cupin_2; pfam07883
866913010253	benzoate transport; Region: 2A0115; TIGR00895
866913010254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010255	putative substrate translocation pore; other site
866913010256	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
866913010257	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913010258	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913010259	dimerization interface [polypeptide binding]; other site
866913010260	hypothetical protein; Provisional; Region: PRK01821
866913010261	hypothetical protein; Provisional; Region: PRK10711
866913010262	cytidine deaminase; Provisional; Region: PRK09027
866913010263	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
866913010264	active site
866913010265	catalytic motif [active]
866913010266	Zn binding site [ion binding]; other site
866913010267	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
866913010268	active site
866913010269	catalytic motif [active]
866913010270	Zn binding site [ion binding]; other site
866913010271	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866913010272	putative active site [active]
866913010273	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
866913010274	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
866913010275	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913010276	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913010277	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
866913010278	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
866913010279	homodimer interface [polypeptide binding]; other site
866913010280	active site
866913010281	FMN binding site [chemical binding]; other site
866913010282	substrate binding site [chemical binding]; other site
866913010283	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866913010284	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866913010285	TM-ABC transporter signature motif; other site
866913010286	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
866913010287	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
866913010288	Walker A/P-loop; other site
866913010289	ATP binding site [chemical binding]; other site
866913010290	Q-loop/lid; other site
866913010291	ABC transporter signature motif; other site
866913010292	Walker B; other site
866913010293	D-loop; other site
866913010294	H-loop/switch region; other site
866913010295	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866913010296	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
866913010297	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
866913010298	ligand binding site [chemical binding]; other site
866913010299	calcium binding site [ion binding]; other site
866913010300	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
866913010301	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913010302	DNA binding site [nucleotide binding]
866913010303	domain linker motif; other site
866913010304	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
866913010305	dimerization interface (closed form) [polypeptide binding]; other site
866913010306	ligand binding site [chemical binding]; other site
866913010307	Predicted membrane protein [Function unknown]; Region: COG2311
866913010308	hypothetical protein; Provisional; Region: PRK10835
866913010309	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
866913010310	GTP cyclohydrolase I; Provisional; Region: PLN03044
866913010311	active site
866913010312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913010313	non-specific DNA binding site [nucleotide binding]; other site
866913010314	salt bridge; other site
866913010315	sequence-specific DNA binding site [nucleotide binding]; other site
866913010316	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
866913010317	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
866913010318	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
866913010319	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
866913010320	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866913010321	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913010322	motif II; other site
866913010323	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
866913010324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010325	putative substrate translocation pore; other site
866913010326	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
866913010327	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913010328	N-terminal plug; other site
866913010329	ligand-binding site [chemical binding]; other site
866913010330	lysine transporter; Provisional; Region: PRK10836
866913010331	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
866913010332	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913010333	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
866913010334	putative dimerization interface [polypeptide binding]; other site
866913010335	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
866913010336	endonuclease IV; Provisional; Region: PRK01060
866913010337	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
866913010338	AP (apurinic/apyrimidinic) site pocket; other site
866913010339	DNA interaction; other site
866913010340	Metal-binding active site; metal-binding site
866913010341	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
866913010342	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
866913010343	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866913010344	active site
866913010345	P-loop; other site
866913010346	phosphorylation site [posttranslational modification]
866913010347	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
866913010348	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
866913010349	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
866913010350	putative substrate binding site [chemical binding]; other site
866913010351	putative ATP binding site [chemical binding]; other site
866913010352	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
866913010353	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913010354	active site
866913010355	phosphorylation site [posttranslational modification]
866913010356	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866913010357	dimerization domain swap beta strand [polypeptide binding]; other site
866913010358	regulatory protein interface [polypeptide binding]; other site
866913010359	active site
866913010360	regulatory phosphorylation site [posttranslational modification]; other site
866913010361	sugar efflux transporter B; Provisional; Region: PRK15011
866913010362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010363	putative substrate translocation pore; other site
866913010364	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
866913010365	elongation factor P; Provisional; Region: PRK04542
866913010366	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
866913010367	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
866913010368	RNA binding site [nucleotide binding]; other site
866913010369	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
866913010370	RNA binding site [nucleotide binding]; other site
866913010371	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
866913010372	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
866913010373	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
866913010374	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866913010375	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
866913010376	active site
866913010377	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
866913010378	NlpC/P60 family; Region: NLPC_P60; pfam00877
866913010379	phage resistance protein; Provisional; Region: PRK10551
866913010380	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
866913010381	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913010382	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866913010383	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
866913010384	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
866913010385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913010386	dimer interface [polypeptide binding]; other site
866913010387	conserved gate region; other site
866913010388	putative PBP binding loops; other site
866913010389	ABC-ATPase subunit interface; other site
866913010390	microcin C ABC transporter permease; Provisional; Region: PRK15021
866913010391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913010392	dimer interface [polypeptide binding]; other site
866913010393	conserved gate region; other site
866913010394	ABC-ATPase subunit interface; other site
866913010395	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
866913010396	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913010397	Walker A/P-loop; other site
866913010398	ATP binding site [chemical binding]; other site
866913010399	Q-loop/lid; other site
866913010400	ABC transporter signature motif; other site
866913010401	Walker B; other site
866913010402	D-loop; other site
866913010403	H-loop/switch region; other site
866913010404	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
866913010405	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866913010406	Walker A/P-loop; other site
866913010407	ATP binding site [chemical binding]; other site
866913010408	Q-loop/lid; other site
866913010409	ABC transporter signature motif; other site
866913010410	Walker B; other site
866913010411	D-loop; other site
866913010412	H-loop/switch region; other site
866913010413	hypothetical protein; Provisional; Region: PRK11835
866913010414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010415	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
866913010416	putative substrate translocation pore; other site
866913010417	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
866913010418	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913010419	RNA binding surface [nucleotide binding]; other site
866913010420	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
866913010421	active site
866913010422	uracil binding [chemical binding]; other site
866913010423	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
866913010424	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866913010425	ATP binding site [chemical binding]; other site
866913010426	putative Mg++ binding site [ion binding]; other site
866913010427	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913010428	nucleotide binding region [chemical binding]; other site
866913010429	ATP-binding site [chemical binding]; other site
866913010430	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
866913010431	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
866913010432	5S rRNA interface [nucleotide binding]; other site
866913010433	CTC domain interface [polypeptide binding]; other site
866913010434	L16 interface [polypeptide binding]; other site
866913010435	Nucleoid-associated protein [General function prediction only]; Region: COG3081
866913010436	nucleoid-associated protein NdpA; Validated; Region: PRK00378
866913010437	hypothetical protein; Provisional; Region: PRK13689
866913010438	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
866913010439	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
866913010440	Sulfatase; Region: Sulfatase; cl17466
866913010441	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
866913010442	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
866913010443	Catalytic site [active]
866913010444	DinI-like family; Region: DinI; cl11630
866913010445	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
866913010446	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913010447	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913010448	Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903
866913010449	Phage head maturation protease [General function prediction only]; Region: COG3740
866913010450	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
866913010451	Phage-related protein [Function unknown]; Region: COG4695; cl01923
866913010452	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
866913010453	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
866913010454	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
866913010455	Protein of unknown function (DUF968); Region: DUF968; pfam06147
866913010456	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
866913010457	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
866913010458	DinI-like family; Region: DinI; cl11630
866913010459	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
866913010460	transcriptional regulator NarP; Provisional; Region: PRK10403
866913010461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913010462	active site
866913010463	phosphorylation site [posttranslational modification]
866913010464	intermolecular recognition site; other site
866913010465	dimerization interface [polypeptide binding]; other site
866913010466	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913010467	DNA binding residues [nucleotide binding]
866913010468	dimerization interface [polypeptide binding]; other site
866913010469	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
866913010470	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
866913010471	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
866913010472	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
866913010473	catalytic residues [active]
866913010474	central insert; other site
866913010475	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
866913010476	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
866913010477	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
866913010478	heme exporter protein CcmC; Region: ccmC; TIGR01191
866913010479	heme exporter protein CcmB; Region: ccmB; TIGR01190
866913010480	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
866913010481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913010482	Walker A/P-loop; other site
866913010483	ATP binding site [chemical binding]; other site
866913010484	Q-loop/lid; other site
866913010485	ABC transporter signature motif; other site
866913010486	Walker B; other site
866913010487	D-loop; other site
866913010488	H-loop/switch region; other site
866913010489	cytochrome c-type protein NapC; Provisional; Region: PRK10617
866913010490	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
866913010491	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
866913010492	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
866913010493	4Fe-4S binding domain; Region: Fer4_5; pfam12801
866913010494	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866913010495	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
866913010496	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
866913010497	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
866913010498	[4Fe-4S] binding site [ion binding]; other site
866913010499	molybdopterin cofactor binding site; other site
866913010500	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
866913010501	molybdopterin cofactor binding site; other site
866913010502	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
866913010503	ferredoxin-type protein; Provisional; Region: PRK10194
866913010504	4Fe-4S binding domain; Region: Fer4; cl02805
866913010505	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
866913010506	secondary substrate binding site; other site
866913010507	primary substrate binding site; other site
866913010508	inhibition loop; other site
866913010509	dimerization interface [polypeptide binding]; other site
866913010510	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
866913010511	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
866913010512	Walker A/P-loop; other site
866913010513	ATP binding site [chemical binding]; other site
866913010514	Q-loop/lid; other site
866913010515	ABC transporter signature motif; other site
866913010516	Walker B; other site
866913010517	D-loop; other site
866913010518	H-loop/switch region; other site
866913010519	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
866913010520	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
866913010521	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
866913010522	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913010523	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
866913010524	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
866913010525	DNA binding site [nucleotide binding]
866913010526	active site
866913010527	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
866913010528	ApbE family; Region: ApbE; pfam02424
866913010529	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
866913010530	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
866913010531	trimer interface [polypeptide binding]; other site
866913010532	eyelet of channel; other site
866913010533	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
866913010534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913010535	ATP binding site [chemical binding]; other site
866913010536	G-X-G motif; other site
866913010537	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
866913010538	putative binding surface; other site
866913010539	active site
866913010540	transcriptional regulator RcsB; Provisional; Region: PRK10840
866913010541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913010542	active site
866913010543	phosphorylation site [posttranslational modification]
866913010544	intermolecular recognition site; other site
866913010545	dimerization interface [polypeptide binding]; other site
866913010546	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913010547	DNA binding residues [nucleotide binding]
866913010548	dimerization interface [polypeptide binding]; other site
866913010549	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
866913010550	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913010551	dimer interface [polypeptide binding]; other site
866913010552	phosphorylation site [posttranslational modification]
866913010553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913010554	ATP binding site [chemical binding]; other site
866913010555	Mg2+ binding site [ion binding]; other site
866913010556	G-X-G motif; other site
866913010557	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
866913010558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913010559	active site
866913010560	phosphorylation site [posttranslational modification]
866913010561	intermolecular recognition site; other site
866913010562	dimerization interface [polypeptide binding]; other site
866913010563	DNA gyrase subunit A; Validated; Region: PRK05560
866913010564	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866913010565	CAP-like domain; other site
866913010566	active site
866913010567	primary dimer interface [polypeptide binding]; other site
866913010568	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866913010569	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866913010570	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866913010571	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866913010572	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866913010573	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866913010574	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
866913010575	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
866913010576	active site pocket [active]
866913010577	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
866913010578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010579	putative substrate translocation pore; other site
866913010580	Transcriptional regulators [Transcription]; Region: GntR; COG1802
866913010581	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913010582	DNA-binding site [nucleotide binding]; DNA binding site
866913010583	FCD domain; Region: FCD; pfam07729
866913010584	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
866913010585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913010586	S-adenosylmethionine binding site [chemical binding]; other site
866913010587	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
866913010588	ATP cone domain; Region: ATP-cone; pfam03477
866913010589	Class I ribonucleotide reductase; Region: RNR_I; cd01679
866913010590	active site
866913010591	dimer interface [polypeptide binding]; other site
866913010592	catalytic residues [active]
866913010593	effector binding site; other site
866913010594	R2 peptide binding site; other site
866913010595	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
866913010596	dimer interface [polypeptide binding]; other site
866913010597	putative radical transfer pathway; other site
866913010598	diiron center [ion binding]; other site
866913010599	tyrosyl radical; other site
866913010600	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
866913010601	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
866913010602	catalytic loop [active]
866913010603	iron binding site [ion binding]; other site
866913010604	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913010605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010606	putative substrate translocation pore; other site
866913010607	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
866913010608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913010609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866913010610	dimerization interface [polypeptide binding]; other site
866913010611	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
866913010612	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
866913010613	active site
866913010614	catalytic site [active]
866913010615	metal binding site [ion binding]; metal-binding site
866913010616	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
866913010617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010618	putative substrate translocation pore; other site
866913010619	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
866913010620	hydroxyglutarate oxidase; Provisional; Region: PRK11728
866913010621	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
866913010622	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
866913010623	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
866913010624	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
866913010625	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866913010626	Cysteine-rich domain; Region: CCG; pfam02754
866913010627	Cysteine-rich domain; Region: CCG; pfam02754
866913010628	deubiquitinase SseL; Provisional; Region: PRK14848
866913010629	hypothetical protein; Provisional; Region: PRK03673
866913010630	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
866913010631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010632	D-galactonate transporter; Region: 2A0114; TIGR00893
866913010633	putative substrate translocation pore; other site
866913010634	L-rhamnonate dehydratase; Provisional; Region: PRK15440
866913010635	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
866913010636	putative active site pocket [active]
866913010637	putative metal binding site [ion binding]; other site
866913010638	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
866913010639	Transcriptional regulator [Transcription]; Region: IclR; COG1414
866913010640	Bacterial transcriptional regulator; Region: IclR; pfam01614
866913010641	hypothetical protein; Provisional; Region: PRK03673
866913010642	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
866913010643	putative MPT binding site; other site
866913010644	Competence-damaged protein; Region: CinA; cl00666
866913010645	YfaZ precursor; Region: YfaZ; pfam07437
866913010646	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
866913010647	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
866913010648	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
866913010649	catalytic core [active]
866913010650	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
866913010651	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
866913010652	inhibitor-cofactor binding pocket; inhibition site
866913010653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913010654	catalytic residue [active]
866913010655	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
866913010656	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
866913010657	Ligand binding site; other site
866913010658	Putative Catalytic site; other site
866913010659	DXD motif; other site
866913010660	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
866913010661	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
866913010662	active site
866913010663	substrate binding site [chemical binding]; other site
866913010664	cosubstrate binding site; other site
866913010665	catalytic site [active]
866913010666	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
866913010667	active site
866913010668	hexamer interface [polypeptide binding]; other site
866913010669	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
866913010670	NAD binding site [chemical binding]; other site
866913010671	substrate binding site [chemical binding]; other site
866913010672	active site
866913010673	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
866913010674	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
866913010675	putative active site [active]
866913010676	putative catalytic site [active]
866913010677	putative Zn binding site [ion binding]; other site
866913010678	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
866913010679	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
866913010680	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
866913010681	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
866913010682	signal transduction protein PmrD; Provisional; Region: PRK15450
866913010683	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
866913010684	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
866913010685	acyl-activating enzyme (AAE) consensus motif; other site
866913010686	putative AMP binding site [chemical binding]; other site
866913010687	putative active site [active]
866913010688	putative CoA binding site [chemical binding]; other site
866913010689	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
866913010690	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
866913010691	active site
866913010692	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866913010693	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
866913010694	substrate binding site [chemical binding]; other site
866913010695	oxyanion hole (OAH) forming residues; other site
866913010696	trimer interface [polypeptide binding]; other site
866913010697	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
866913010698	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
866913010699	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
866913010700	dimer interface [polypeptide binding]; other site
866913010701	tetramer interface [polypeptide binding]; other site
866913010702	PYR/PP interface [polypeptide binding]; other site
866913010703	TPP binding site [chemical binding]; other site
866913010704	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
866913010705	TPP-binding site; other site
866913010706	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
866913010707	isochorismate synthases; Region: isochor_syn; TIGR00543
866913010708	hypothetical protein; Provisional; Region: PRK10404
866913010709	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913010710	Coenzyme A binding pocket [chemical binding]; other site
866913010711	ribonuclease BN; Region: true_RNase_BN; TIGR02649
866913010712	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
866913010713	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
866913010714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913010715	active site
866913010716	phosphorylation site [posttranslational modification]
866913010717	intermolecular recognition site; other site
866913010718	dimerization interface [polypeptide binding]; other site
866913010719	von Willebrand factor; Region: vWF_A; pfam12450
866913010720	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
866913010721	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
866913010722	metal ion-dependent adhesion site (MIDAS); other site
866913010723	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
866913010724	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
866913010725	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
866913010726	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
866913010727	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
866913010728	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
866913010729	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
866913010730	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
866913010731	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
866913010732	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
866913010733	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
866913010734	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
866913010735	4Fe-4S binding domain; Region: Fer4; pfam00037
866913010736	4Fe-4S binding domain; Region: Fer4; pfam00037
866913010737	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
866913010738	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
866913010739	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
866913010740	catalytic loop [active]
866913010741	iron binding site [ion binding]; other site
866913010742	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
866913010743	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
866913010744	[4Fe-4S] binding site [ion binding]; other site
866913010745	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
866913010746	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
866913010747	SLBB domain; Region: SLBB; pfam10531
866913010748	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
866913010749	NADH dehydrogenase subunit E; Validated; Region: PRK07539
866913010750	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
866913010751	putative dimer interface [polypeptide binding]; other site
866913010752	[2Fe-2S] cluster binding site [ion binding]; other site
866913010753	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
866913010754	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
866913010755	NADH dehydrogenase subunit D; Validated; Region: PRK06075
866913010756	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
866913010757	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
866913010758	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
866913010759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913010760	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
866913010761	putative dimerization interface [polypeptide binding]; other site
866913010762	aminotransferase AlaT; Validated; Region: PRK09265
866913010763	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913010764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913010765	homodimer interface [polypeptide binding]; other site
866913010766	catalytic residue [active]
866913010767	5'-nucleotidase; Provisional; Region: PRK03826
866913010768	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
866913010769	transmembrane helices; other site
866913010770	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
866913010771	TrkA-C domain; Region: TrkA_C; pfam02080
866913010772	TrkA-C domain; Region: TrkA_C; pfam02080
866913010773	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
866913010774	putative phosphatase; Provisional; Region: PRK11587
866913010775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913010776	motif II; other site
866913010777	hypothetical protein; Validated; Region: PRK05445
866913010778	hypothetical protein; Provisional; Region: PRK01816
866913010779	propionate/acetate kinase; Provisional; Region: PRK12379
866913010780	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
866913010781	phosphate acetyltransferase; Reviewed; Region: PRK05632
866913010782	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866913010783	DRTGG domain; Region: DRTGG; pfam07085
866913010784	phosphate acetyltransferase; Region: pta; TIGR00651
866913010785	hypothetical protein; Provisional; Region: PRK11588
866913010786	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
866913010787	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
866913010788	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866913010789	PYR/PP interface [polypeptide binding]; other site
866913010790	dimer interface [polypeptide binding]; other site
866913010791	TPP binding site [chemical binding]; other site
866913010792	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866913010793	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
866913010794	TPP-binding site [chemical binding]; other site
866913010795	dimer interface [polypeptide binding]; other site
866913010796	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
866913010797	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
866913010798	active site
866913010799	P-loop; other site
866913010800	phosphorylation site [posttranslational modification]
866913010801	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913010802	active site
866913010803	phosphorylation site [posttranslational modification]
866913010804	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866913010805	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913010806	DNA binding site [nucleotide binding]
866913010807	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
866913010808	putative dimerization interface [polypeptide binding]; other site
866913010809	putative ligand binding site [chemical binding]; other site
866913010810	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
866913010811	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
866913010812	nudix motif; other site
866913010813	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
866913010814	active site
866913010815	metal binding site [ion binding]; metal-binding site
866913010816	homotetramer interface [polypeptide binding]; other site
866913010817	glutathione S-transferase; Provisional; Region: PRK15113
866913010818	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
866913010819	C-terminal domain interface [polypeptide binding]; other site
866913010820	GSH binding site (G-site) [chemical binding]; other site
866913010821	dimer interface [polypeptide binding]; other site
866913010822	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
866913010823	N-terminal domain interface [polypeptide binding]; other site
866913010824	putative dimer interface [polypeptide binding]; other site
866913010825	putative substrate binding pocket (H-site) [chemical binding]; other site
866913010826	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
866913010827	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
866913010828	C-terminal domain interface [polypeptide binding]; other site
866913010829	GSH binding site (G-site) [chemical binding]; other site
866913010830	dimer interface [polypeptide binding]; other site
866913010831	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
866913010832	N-terminal domain interface [polypeptide binding]; other site
866913010833	putative dimer interface [polypeptide binding]; other site
866913010834	active site
866913010835	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
866913010836	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
866913010837	putative NAD(P) binding site [chemical binding]; other site
866913010838	putative active site [active]
866913010839	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
866913010840	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866913010841	Walker A/P-loop; other site
866913010842	ATP binding site [chemical binding]; other site
866913010843	Q-loop/lid; other site
866913010844	ABC transporter signature motif; other site
866913010845	Walker B; other site
866913010846	D-loop; other site
866913010847	H-loop/switch region; other site
866913010848	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913010849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913010850	dimer interface [polypeptide binding]; other site
866913010851	conserved gate region; other site
866913010852	putative PBP binding loops; other site
866913010853	ABC-ATPase subunit interface; other site
866913010854	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866913010855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913010856	dimer interface [polypeptide binding]; other site
866913010857	conserved gate region; other site
866913010858	putative PBP binding loops; other site
866913010859	ABC-ATPase subunit interface; other site
866913010860	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
866913010861	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913010862	substrate binding pocket [chemical binding]; other site
866913010863	membrane-bound complex binding site; other site
866913010864	hinge residues; other site
866913010865	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
866913010866	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913010867	substrate binding pocket [chemical binding]; other site
866913010868	membrane-bound complex binding site; other site
866913010869	hinge residues; other site
866913010870	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
866913010871	Flavoprotein; Region: Flavoprotein; pfam02441
866913010872	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
866913010873	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
866913010874	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
866913010875	dimer interface [polypeptide binding]; other site
866913010876	active site
866913010877	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866913010878	substrate binding site [chemical binding]; other site
866913010879	catalytic residue [active]
866913010880	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
866913010881	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
866913010882	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
866913010883	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866913010884	catalytic residue [active]
866913010885	PAS fold; Region: PAS_4; pfam08448
866913010886	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
866913010887	putative active site [active]
866913010888	heme pocket [chemical binding]; other site
866913010889	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
866913010890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913010891	Walker A motif; other site
866913010892	ATP binding site [chemical binding]; other site
866913010893	Walker B motif; other site
866913010894	arginine finger; other site
866913010895	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866913010896	amidophosphoribosyltransferase; Provisional; Region: PRK09246
866913010897	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
866913010898	active site
866913010899	tetramer interface [polypeptide binding]; other site
866913010900	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913010901	active site
866913010902	colicin V production protein; Provisional; Region: PRK10845
866913010903	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
866913010904	cell division protein DedD; Provisional; Region: PRK11633
866913010905	Sporulation related domain; Region: SPOR; pfam05036
866913010906	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
866913010907	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866913010908	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866913010909	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
866913010910	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
866913010911	hypothetical protein; Provisional; Region: PRK10847
866913010912	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866913010913	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
866913010914	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
866913010915	dimerization interface 3.5A [polypeptide binding]; other site
866913010916	active site
866913010917	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
866913010918	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866913010919	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
866913010920	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
866913010921	ligand binding site [chemical binding]; other site
866913010922	NAD binding site [chemical binding]; other site
866913010923	catalytic site [active]
866913010924	homodimer interface [polypeptide binding]; other site
866913010925	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
866913010926	putative transporter; Provisional; Region: PRK12382
866913010927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010928	putative substrate translocation pore; other site
866913010929	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913010930	non-specific DNA binding site [nucleotide binding]; other site
866913010931	salt bridge; other site
866913010932	sequence-specific DNA binding site [nucleotide binding]; other site
866913010933	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
866913010934	CAAX protease self-immunity; Region: Abi; pfam02517
866913010935	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
866913010936	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
866913010937	dimer interface [polypeptide binding]; other site
866913010938	active site
866913010939	Uncharacterized conserved protein [Function unknown]; Region: COG4121
866913010940	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
866913010941	YfcL protein; Region: YfcL; pfam08891
866913010942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
866913010943	hypothetical protein; Provisional; Region: PRK10621
866913010944	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
866913010945	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
866913010946	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
866913010947	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
866913010948	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
866913010949	Tetramer interface [polypeptide binding]; other site
866913010950	active site
866913010951	FMN-binding site [chemical binding]; other site
866913010952	HemK family putative methylases; Region: hemK_fam; TIGR00536
866913010953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913010954	S-adenosylmethionine binding site [chemical binding]; other site
866913010955	hypothetical protein; Provisional; Region: PRK04946
866913010956	Smr domain; Region: Smr; pfam01713
866913010957	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866913010958	catalytic core [active]
866913010959	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
866913010960	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866913010961	substrate binding site [chemical binding]; other site
866913010962	oxyanion hole (OAH) forming residues; other site
866913010963	trimer interface [polypeptide binding]; other site
866913010964	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866913010965	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866913010966	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
866913010967	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866913010968	dimer interface [polypeptide binding]; other site
866913010969	active site
866913010970	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
866913010971	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
866913010972	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
866913010973	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
866913010974	outer membrane protease; Reviewed; Region: PRK10993
866913010975	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
866913010976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913010977	active site
866913010978	phosphorylation site [posttranslational modification]
866913010979	intermolecular recognition site; other site
866913010980	dimerization interface [polypeptide binding]; other site
866913010981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866913010982	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866913010983	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
866913010984	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
866913010985	dimerization interface [polypeptide binding]; other site
866913010986	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913010987	dimer interface [polypeptide binding]; other site
866913010988	phosphorylation site [posttranslational modification]
866913010989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913010990	ATP binding site [chemical binding]; other site
866913010991	Mg2+ binding site [ion binding]; other site
866913010992	G-X-G motif; other site
866913010993	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
866913010994	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
866913010995	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
866913010996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913010998	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
866913010999	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
866913011000	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
866913011001	putative acyl-acceptor binding pocket; other site
866913011002	aminotransferase; Validated; Region: PRK08175
866913011003	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913011004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913011005	homodimer interface [polypeptide binding]; other site
866913011006	catalytic residue [active]
866913011007	glucokinase; Provisional; Region: glk; PRK00292
866913011008	glucokinase, proteobacterial type; Region: glk; TIGR00749
866913011009	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
866913011010	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
866913011011	Cl- selectivity filter; other site
866913011012	Cl- binding residues [ion binding]; other site
866913011013	pore gating glutamate residue; other site
866913011014	dimer interface [polypeptide binding]; other site
866913011015	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
866913011016	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
866913011017	dimer interface [polypeptide binding]; other site
866913011018	PYR/PP interface [polypeptide binding]; other site
866913011019	TPP binding site [chemical binding]; other site
866913011020	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866913011021	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
866913011022	TPP-binding site [chemical binding]; other site
866913011023	dimer interface [polypeptide binding]; other site
866913011024	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913011025	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913011026	active site
866913011027	catalytic tetrad [active]
866913011028	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
866913011029	manganese transport protein MntH; Reviewed; Region: PRK00701
866913011030	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
866913011031	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
866913011032	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
866913011033	Nucleoside recognition; Region: Gate; pfam07670
866913011034	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
866913011035	MASE1; Region: MASE1; pfam05231
866913011036	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866913011037	diguanylate cyclase; Region: GGDEF; smart00267
866913011038	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913011039	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
866913011040	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
866913011041	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
866913011042	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866913011043	active site
866913011044	HIGH motif; other site
866913011045	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866913011046	active site
866913011047	KMSKS motif; other site
866913011048	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
866913011049	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913011050	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
866913011051	putative dimerization interface [polypeptide binding]; other site
866913011052	putative substrate binding pocket [chemical binding]; other site
866913011053	XapX domain; Region: XapX; TIGR03510
866913011054	nucleoside transporter; Region: 2A0110; TIGR00889
866913011055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913011056	putative substrate translocation pore; other site
866913011057	purine nucleoside phosphorylase; Provisional; Region: PRK08202
866913011058	hypothetical protein; Provisional; Region: PRK11528
866913011059	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913011060	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913011061	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
866913011062	putative dimerization interface [polypeptide binding]; other site
866913011063	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
866913011064	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
866913011065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
866913011066	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
866913011067	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
866913011068	nucleotide binding pocket [chemical binding]; other site
866913011069	K-X-D-G motif; other site
866913011070	catalytic site [active]
866913011071	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
866913011072	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
866913011073	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
866913011074	Dimer interface [polypeptide binding]; other site
866913011075	BRCT sequence motif; other site
866913011076	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
866913011077	cell division protein ZipA; Provisional; Region: PRK03427
866913011078	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
866913011079	FtsZ protein binding site [polypeptide binding]; other site
866913011080	putative sulfate transport protein CysZ; Validated; Region: PRK04949
866913011081	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866913011082	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
866913011083	dimer interface [polypeptide binding]; other site
866913011084	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913011085	catalytic residue [active]
866913011086	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866913011087	dimerization domain swap beta strand [polypeptide binding]; other site
866913011088	regulatory protein interface [polypeptide binding]; other site
866913011089	active site
866913011090	regulatory phosphorylation site [posttranslational modification]; other site
866913011091	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
866913011092	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
866913011093	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866913011094	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866913011095	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
866913011096	HPr interaction site; other site
866913011097	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866913011098	active site
866913011099	phosphorylation site [posttranslational modification]
866913011100	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
866913011101	dimer interface [polypeptide binding]; other site
866913011102	pyridoxamine kinase; Validated; Region: PRK05756
866913011103	pyridoxal binding site [chemical binding]; other site
866913011104	ATP binding site [chemical binding]; other site
866913011105	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
866913011106	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913011107	DNA-binding site [nucleotide binding]; DNA binding site
866913011108	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913011109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913011110	homodimer interface [polypeptide binding]; other site
866913011111	catalytic residue [active]
866913011112	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
866913011113	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
866913011114	catalytic triad [active]
866913011115	hypothetical protein; Provisional; Region: PRK10318
866913011116	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
866913011117	Transglycosylase; Region: Transgly; cl17702
866913011118	cysteine synthase B; Region: cysM; TIGR01138
866913011119	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
866913011120	dimer interface [polypeptide binding]; other site
866913011121	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913011122	catalytic residue [active]
866913011123	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
866913011124	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
866913011125	Walker A/P-loop; other site
866913011126	ATP binding site [chemical binding]; other site
866913011127	Q-loop/lid; other site
866913011128	ABC transporter signature motif; other site
866913011129	Walker B; other site
866913011130	D-loop; other site
866913011131	H-loop/switch region; other site
866913011132	TOBE-like domain; Region: TOBE_3; pfam12857
866913011133	sulfate transport protein; Provisional; Region: cysT; CHL00187
866913011134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913011135	dimer interface [polypeptide binding]; other site
866913011136	conserved gate region; other site
866913011137	putative PBP binding loops; other site
866913011138	ABC-ATPase subunit interface; other site
866913011139	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
866913011140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913011141	dimer interface [polypeptide binding]; other site
866913011142	conserved gate region; other site
866913011143	putative PBP binding loops; other site
866913011144	ABC-ATPase subunit interface; other site
866913011145	thiosulfate transporter subunit; Provisional; Region: PRK10852
866913011146	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
866913011147	short chain dehydrogenase; Provisional; Region: PRK08226
866913011148	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
866913011149	NAD binding site [chemical binding]; other site
866913011150	homotetramer interface [polypeptide binding]; other site
866913011151	homodimer interface [polypeptide binding]; other site
866913011152	active site
866913011153	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
866913011154	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
866913011155	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
866913011156	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
866913011157	putative acetyltransferase; Provisional; Region: PRK03624
866913011158	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913011159	Coenzyme A binding pocket [chemical binding]; other site
866913011160	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
866913011161	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866913011162	active site
866913011163	metal binding site [ion binding]; metal-binding site
866913011164	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
866913011165	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
866913011166	transcriptional regulator EutR; Provisional; Region: PRK10130
866913011167	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913011168	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913011169	carboxysome structural protein EutK; Provisional; Region: PRK15466
866913011170	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
866913011171	Hexamer interface [polypeptide binding]; other site
866913011172	Hexagonal pore residue; other site
866913011173	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
866913011174	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
866913011175	putative hexamer interface [polypeptide binding]; other site
866913011176	putative hexagonal pore; other site
866913011177	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
866913011178	putative hexamer interface [polypeptide binding]; other site
866913011179	putative hexagonal pore; other site
866913011180	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
866913011181	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
866913011182	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
866913011183	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
866913011184	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
866913011185	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
866913011186	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
866913011187	active site
866913011188	metal binding site [ion binding]; metal-binding site
866913011189	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
866913011190	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913011191	nucleotide binding site [chemical binding]; other site
866913011192	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
866913011193	putative catalytic cysteine [active]
866913011194	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
866913011195	Hexamer/Pentamer interface [polypeptide binding]; other site
866913011196	central pore; other site
866913011197	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
866913011198	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
866913011199	Hexamer interface [polypeptide binding]; other site
866913011200	Putative hexagonal pore residue; other site
866913011201	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
866913011202	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
866913011203	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
866913011204	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
866913011205	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
866913011206	G1 box; other site
866913011207	GTP/Mg2+ binding site [chemical binding]; other site
866913011208	G2 box; other site
866913011209	Switch I region; other site
866913011210	G3 box; other site
866913011211	Switch II region; other site
866913011212	G4 box; other site
866913011213	G5 box; other site
866913011214	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
866913011215	putative hexamer interface [polypeptide binding]; other site
866913011216	putative hexagonal pore; other site
866913011217	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913011218	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
866913011219	Malic enzyme, N-terminal domain; Region: malic; pfam00390
866913011220	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
866913011221	putative NAD(P) binding site [chemical binding]; other site
866913011222	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
866913011223	transaldolase-like protein; Provisional; Region: PTZ00411
866913011224	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
866913011225	active site
866913011226	dimer interface [polypeptide binding]; other site
866913011227	catalytic residue [active]
866913011228	transketolase; Reviewed; Region: PRK12753
866913011229	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
866913011230	TPP-binding site [chemical binding]; other site
866913011231	dimer interface [polypeptide binding]; other site
866913011232	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866913011233	PYR/PP interface [polypeptide binding]; other site
866913011234	dimer interface [polypeptide binding]; other site
866913011235	TPP binding site [chemical binding]; other site
866913011236	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866913011237	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
866913011238	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
866913011239	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
866913011240	dimer interface [polypeptide binding]; other site
866913011241	ADP-ribose binding site [chemical binding]; other site
866913011242	active site
866913011243	nudix motif; other site
866913011244	metal binding site [ion binding]; metal-binding site
866913011245	putative periplasmic esterase; Provisional; Region: PRK03642
866913011246	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
866913011247	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
866913011248	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
866913011249	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913011250	dimerization interface [polypeptide binding]; other site
866913011251	Histidine kinase; Region: HisKA_3; pfam07730
866913011252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913011253	ATP binding site [chemical binding]; other site
866913011254	Mg2+ binding site [ion binding]; other site
866913011255	G-X-G motif; other site
866913011256	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
866913011257	Protein export membrane protein; Region: SecD_SecF; cl14618
866913011258	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
866913011259	ArsC family; Region: ArsC; pfam03960
866913011260	putative catalytic residues [active]
866913011261	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
866913011262	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
866913011263	metal binding site [ion binding]; metal-binding site
866913011264	dimer interface [polypeptide binding]; other site
866913011265	hypothetical protein; Provisional; Region: PRK13664
866913011266	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
866913011267	Helicase; Region: Helicase_RecD; pfam05127
866913011268	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
866913011269	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
866913011270	Predicted metalloprotease [General function prediction only]; Region: COG2321
866913011271	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
866913011272	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
866913011273	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
866913011274	ATP binding site [chemical binding]; other site
866913011275	active site
866913011276	substrate binding site [chemical binding]; other site
866913011277	lipoprotein; Provisional; Region: PRK11679
866913011278	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
866913011279	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
866913011280	dihydrodipicolinate synthase; Region: dapA; TIGR00674
866913011281	dimer interface [polypeptide binding]; other site
866913011282	active site
866913011283	catalytic residue [active]
866913011284	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
866913011285	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
866913011286	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
866913011287	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
866913011288	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
866913011289	catalytic triad [active]
866913011290	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
866913011291	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866913011292	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866913011293	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
866913011294	Peptidase family M48; Region: Peptidase_M48; cl12018
866913011295	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
866913011296	ArsC family; Region: ArsC; pfam03960
866913011297	catalytic residues [active]
866913011298	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
866913011299	DNA replication initiation factor; Provisional; Region: PRK08084
866913011300	uracil transporter; Provisional; Region: PRK10720
866913011301	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866913011302	active site
866913011303	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
866913011304	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
866913011305	dimerization interface [polypeptide binding]; other site
866913011306	putative ATP binding site [chemical binding]; other site
866913011307	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
866913011308	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
866913011309	active site
866913011310	substrate binding site [chemical binding]; other site
866913011311	cosubstrate binding site; other site
866913011312	catalytic site [active]
866913011313	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
866913011314	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
866913011315	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
866913011316	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
866913011317	putative active site [active]
866913011318	catalytic site [active]
866913011319	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
866913011320	domain interface [polypeptide binding]; other site
866913011321	active site
866913011322	catalytic site [active]
866913011323	exopolyphosphatase; Provisional; Region: PRK10854
866913011324	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913011325	nucleotide binding site [chemical binding]; other site
866913011326	MASE1; Region: MASE1; pfam05231
866913011327	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866913011328	diguanylate cyclase; Region: GGDEF; smart00267
866913011329	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913011330	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
866913011331	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
866913011332	Integrase core domain; Region: rve; pfam00665
866913011333	GMP synthase; Reviewed; Region: guaA; PRK00074
866913011334	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
866913011335	AMP/PPi binding site [chemical binding]; other site
866913011336	candidate oxyanion hole; other site
866913011337	catalytic triad [active]
866913011338	potential glutamine specificity residues [chemical binding]; other site
866913011339	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
866913011340	ATP Binding subdomain [chemical binding]; other site
866913011341	Ligand Binding sites [chemical binding]; other site
866913011342	Dimerization subdomain; other site
866913011343	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
866913011344	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866913011345	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
866913011346	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866913011347	active site
866913011348	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
866913011349	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
866913011350	generic binding surface II; other site
866913011351	generic binding surface I; other site
866913011352	AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319
866913011353	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
866913011354	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
866913011355	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
866913011356	Autotransporter beta-domain; Region: Autotransporter; smart00869
866913011357	outer membrane protein RatA; Provisional; Region: PRK15315
866913011358	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
866913011359	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
866913011360	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
866913011361	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
866913011362	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
866913011363	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
866913011364	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
866913011365	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
866913011366	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
866913011367	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
866913011368	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
866913011369	intimin-like protein SinH; Provisional; Region: PRK15318
866913011370	intimin-like protein SinH; Provisional; Region: PRK15318
866913011371	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
866913011372	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
866913011373	GTP-binding protein Der; Reviewed; Region: PRK00093
866913011374	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
866913011375	G1 box; other site
866913011376	GTP/Mg2+ binding site [chemical binding]; other site
866913011377	Switch I region; other site
866913011378	G2 box; other site
866913011379	Switch II region; other site
866913011380	G3 box; other site
866913011381	G4 box; other site
866913011382	G5 box; other site
866913011383	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
866913011384	G1 box; other site
866913011385	GTP/Mg2+ binding site [chemical binding]; other site
866913011386	Switch I region; other site
866913011387	G2 box; other site
866913011388	G3 box; other site
866913011389	Switch II region; other site
866913011390	G4 box; other site
866913011391	G5 box; other site
866913011392	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
866913011393	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
866913011394	Trp docking motif [polypeptide binding]; other site
866913011395	active site
866913011396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
866913011397	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
866913011398	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
866913011399	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
866913011400	dimer interface [polypeptide binding]; other site
866913011401	motif 1; other site
866913011402	active site
866913011403	motif 2; other site
866913011404	motif 3; other site
866913011405	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
866913011406	anticodon binding site; other site
866913011407	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
866913011408	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
866913011409	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
866913011410	cytoskeletal protein RodZ; Provisional; Region: PRK10856
866913011411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913011412	non-specific DNA binding site [nucleotide binding]; other site
866913011413	salt bridge; other site
866913011414	sequence-specific DNA binding site [nucleotide binding]; other site
866913011415	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
866913011416	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
866913011417	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913011418	FeS/SAM binding site; other site
866913011419	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
866913011420	active site
866913011421	multimer interface [polypeptide binding]; other site
866913011422	4Fe-4S binding domain; Region: Fer4; pfam00037
866913011423	hydrogenase 4 subunit H; Validated; Region: PRK08222
866913011424	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
866913011425	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
866913011426	4Fe-4S binding domain; Region: Fer4; pfam00037
866913011427	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
866913011428	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
866913011429	putative [Fe4-S4] binding site [ion binding]; other site
866913011430	putative molybdopterin cofactor binding site [chemical binding]; other site
866913011431	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
866913011432	putative molybdopterin cofactor binding site; other site
866913011433	penicillin-binding protein 1C; Provisional; Region: PRK11240
866913011434	Transglycosylase; Region: Transgly; pfam00912
866913011435	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866913011436	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
866913011437	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
866913011438	MG2 domain; Region: A2M_N; pfam01835
866913011439	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
866913011440	surface patch; other site
866913011441	thioester region; other site
866913011442	specificity defining residues; other site
866913011443	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
866913011444	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
866913011445	active site residue [active]
866913011446	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
866913011447	active site residue [active]
866913011448	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
866913011449	aminopeptidase B; Provisional; Region: PRK05015
866913011450	Peptidase; Region: DUF3663; pfam12404
866913011451	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
866913011452	interface (dimer of trimers) [polypeptide binding]; other site
866913011453	Substrate-binding/catalytic site; other site
866913011454	Zn-binding sites [ion binding]; other site
866913011455	hypothetical protein; Provisional; Region: PRK10721
866913011456	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
866913011457	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
866913011458	catalytic loop [active]
866913011459	iron binding site [ion binding]; other site
866913011460	chaperone protein HscA; Provisional; Region: hscA; PRK05183
866913011461	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
866913011462	nucleotide binding site [chemical binding]; other site
866913011463	putative NEF/HSP70 interaction site [polypeptide binding]; other site
866913011464	SBD interface [polypeptide binding]; other site
866913011465	co-chaperone HscB; Provisional; Region: hscB; PRK05014
866913011466	DnaJ domain; Region: DnaJ; pfam00226
866913011467	HSP70 interaction site [polypeptide binding]; other site
866913011468	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
866913011469	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
866913011470	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
866913011471	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
866913011472	trimerization site [polypeptide binding]; other site
866913011473	active site
866913011474	cysteine desulfurase; Provisional; Region: PRK14012
866913011475	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
866913011476	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913011477	catalytic residue [active]
866913011478	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
866913011479	Rrf2 family protein; Region: rrf2_super; TIGR00738
866913011480	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
866913011481	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
866913011482	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
866913011483	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
866913011484	active site
866913011485	dimerization interface [polypeptide binding]; other site
866913011486	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
866913011487	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866913011488	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
866913011489	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866913011490	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
866913011491	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
866913011492	FAD binding pocket [chemical binding]; other site
866913011493	FAD binding motif [chemical binding]; other site
866913011494	phosphate binding motif [ion binding]; other site
866913011495	beta-alpha-beta structure motif; other site
866913011496	NAD binding pocket [chemical binding]; other site
866913011497	Iron coordination center [ion binding]; other site
866913011498	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
866913011499	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
866913011500	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866913011501	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
866913011502	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
866913011503	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
866913011504	PRD domain; Region: PRD; pfam00874
866913011505	PRD domain; Region: PRD; pfam00874
866913011506	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
866913011507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913011508	putative substrate translocation pore; other site
866913011509	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
866913011510	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
866913011511	dimer interface [polypeptide binding]; other site
866913011512	active site
866913011513	glycine-pyridoxal phosphate binding site [chemical binding]; other site
866913011514	folate binding site [chemical binding]; other site
866913011515	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
866913011516	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
866913011517	heme-binding site [chemical binding]; other site
866913011518	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
866913011519	FAD binding pocket [chemical binding]; other site
866913011520	FAD binding motif [chemical binding]; other site
866913011521	phosphate binding motif [ion binding]; other site
866913011522	beta-alpha-beta structure motif; other site
866913011523	NAD binding pocket [chemical binding]; other site
866913011524	Heme binding  pocket [chemical binding]; other site
866913011525	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
866913011526	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913011527	DNA binding site [nucleotide binding]
866913011528	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
866913011529	lysine decarboxylase CadA; Provisional; Region: PRK15400
866913011530	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
866913011531	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
866913011532	homodimer interface [polypeptide binding]; other site
866913011533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913011534	catalytic residue [active]
866913011535	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
866913011536	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
866913011537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913011538	putative substrate translocation pore; other site
866913011539	POT family; Region: PTR2; pfam00854
866913011540	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
866913011541	Nitrogen regulatory protein P-II; Region: P-II; smart00938
866913011542	response regulator GlrR; Provisional; Region: PRK15115
866913011543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913011544	active site
866913011545	phosphorylation site [posttranslational modification]
866913011546	intermolecular recognition site; other site
866913011547	dimerization interface [polypeptide binding]; other site
866913011548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913011549	Walker A motif; other site
866913011550	ATP binding site [chemical binding]; other site
866913011551	Walker B motif; other site
866913011552	arginine finger; other site
866913011553	hypothetical protein; Provisional; Region: PRK10722
866913011554	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866913011555	HAMP domain; Region: HAMP; pfam00672
866913011556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913011557	dimer interface [polypeptide binding]; other site
866913011558	phosphorylation site [posttranslational modification]
866913011559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913011560	ATP binding site [chemical binding]; other site
866913011561	Mg2+ binding site [ion binding]; other site
866913011562	G-X-G motif; other site
866913011563	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
866913011564	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
866913011565	dimerization interface [polypeptide binding]; other site
866913011566	ATP binding site [chemical binding]; other site
866913011567	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
866913011568	dimerization interface [polypeptide binding]; other site
866913011569	ATP binding site [chemical binding]; other site
866913011570	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
866913011571	putative active site [active]
866913011572	catalytic triad [active]
866913011573	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
866913011574	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866913011575	substrate binding pocket [chemical binding]; other site
866913011576	membrane-bound complex binding site; other site
866913011577	hinge residues; other site
866913011578	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913011579	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913011580	catalytic residue [active]
866913011581	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
866913011582	nucleoside/Zn binding site; other site
866913011583	dimer interface [polypeptide binding]; other site
866913011584	catalytic motif [active]
866913011585	hypothetical protein; Provisional; Region: PRK11590
866913011586	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
866913011587	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
866913011588	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866913011589	active site turn [active]
866913011590	phosphorylation site [posttranslational modification]
866913011591	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866913011592	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
866913011593	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
866913011594	putative active site [active]
866913011595	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866913011596	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
866913011597	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866913011598	putative active site [active]
866913011599	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
866913011600	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
866913011601	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
866913011602	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
866913011603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913011604	putative substrate translocation pore; other site
866913011605	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913011606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913011607	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866913011608	dimerization interface [polypeptide binding]; other site
866913011609	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
866913011610	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
866913011611	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
866913011612	active site
866913011613	hydrophilic channel; other site
866913011614	dimerization interface [polypeptide binding]; other site
866913011615	catalytic residues [active]
866913011616	active site lid [active]
866913011617	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
866913011618	Recombination protein O N terminal; Region: RecO_N; pfam11967
866913011619	Recombination protein O C terminal; Region: RecO_C; pfam02565
866913011620	GTPase Era; Reviewed; Region: era; PRK00089
866913011621	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
866913011622	G1 box; other site
866913011623	GTP/Mg2+ binding site [chemical binding]; other site
866913011624	Switch I region; other site
866913011625	G2 box; other site
866913011626	Switch II region; other site
866913011627	G3 box; other site
866913011628	G4 box; other site
866913011629	G5 box; other site
866913011630	KH domain; Region: KH_2; pfam07650
866913011631	ribonuclease III; Reviewed; Region: rnc; PRK00102
866913011632	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
866913011633	dimerization interface [polypeptide binding]; other site
866913011634	active site
866913011635	metal binding site [ion binding]; metal-binding site
866913011636	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
866913011637	dsRNA binding site [nucleotide binding]; other site
866913011638	signal peptidase I; Provisional; Region: PRK10861
866913011639	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866913011640	Catalytic site [active]
866913011641	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866913011642	GTP-binding protein LepA; Provisional; Region: PRK05433
866913011643	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
866913011644	G1 box; other site
866913011645	putative GEF interaction site [polypeptide binding]; other site
866913011646	GTP/Mg2+ binding site [chemical binding]; other site
866913011647	Switch I region; other site
866913011648	G2 box; other site
866913011649	G3 box; other site
866913011650	Switch II region; other site
866913011651	G4 box; other site
866913011652	G5 box; other site
866913011653	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
866913011654	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
866913011655	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
866913011656	type III secretion protein GogB; Provisional; Region: PRK15386
866913011657	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913011658	Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900
866913011659	ADP-ribose binding site [chemical binding]; other site
866913011660	putative active site [active]
866913011661	dimer interface [polypeptide binding]; other site
866913011662	Phage Tail Collar Domain; Region: Collar; pfam07484
866913011663	Phage-related protein, tail component [Function unknown]; Region: COG4733
866913011664	Putative phage tail protein; Region: Phage-tail_3; pfam13550
866913011665	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
866913011666	Interdomain contacts; other site
866913011667	Cytokine receptor motif; other site
866913011668	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
866913011669	Fibronectin type III protein; Region: DUF3672; pfam12421
866913011670	Phage-related protein, tail component [Function unknown]; Region: COG4723
866913011671	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
866913011672	MPN+ (JAMM) motif; other site
866913011673	Zinc-binding site [ion binding]; other site
866913011674	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866913011675	NlpC/P60 family; Region: NLPC_P60; cl17555
866913011676	Phage-related protein [Function unknown]; Region: gp18; COG4672
866913011677	Phage-related protein [Function unknown]; Region: COG4718
866913011678	Phage-related minor tail protein [Function unknown]; Region: COG5281
866913011679	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
866913011680	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
866913011681	Minor tail protein T; Region: Phage_tail_T; pfam06223
866913011682	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894
866913011683	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
866913011684	Phage tail protein; Region: Phage_tail_3; pfam08813
866913011685	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
866913011686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866913011687	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866913011688	Probable transposase; Region: OrfB_IS605; pfam01385
866913011689	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866913011690	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
866913011691	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094
866913011692	DNA packaging protein FI; Region: Packaging_FI; pfam14000
866913011693	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
866913011694	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
866913011695	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
866913011696	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
866913011697	tandem repeat interface [polypeptide binding]; other site
866913011698	oligomer interface [polypeptide binding]; other site
866913011699	active site residues [active]
866913011700	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
866913011701	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
866913011702	gpW; Region: gpW; pfam02831
866913011703	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
866913011704	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
866913011705	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
866913011706	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
866913011707	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
866913011708	catalytic residues [active]
866913011709	phage holin, lambda family; Region: holin_lambda; TIGR01594
866913011710	PipA protein; Region: PipA; pfam07108
866913011711	ORF6N domain; Region: ORF6N; pfam10543
866913011712	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
866913011713	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
866913011714	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
866913011715	DinI-like family; Region: DinI; pfam06183
866913011716	NFkB-p65-degrading zinc protease; Region: Peptidase_M85; pfam13678
866913011717	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
866913011718	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
866913011719	putative replication protein; Provisional; Region: PRK12377
866913011720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913011721	Walker A motif; other site
866913011722	ATP binding site [chemical binding]; other site
866913011723	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866913011724	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
866913011725	primosomal protein DnaI; Provisional; Region: PRK02854
866913011726	Bacteriophage CII protein; Region: Phage_CII; pfam05269
866913011727	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
866913011728	transcriptional repressor DicA; Reviewed; Region: PRK09706
866913011729	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866913011730	non-specific DNA binding site [nucleotide binding]; other site
866913011731	sequence-specific DNA binding site [nucleotide binding]; other site
866913011732	salt bridge; other site
866913011733	AAA domain; Region: AAA_31; pfam13614
866913011734	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
866913011735	P-loop; other site
866913011736	Magnesium ion binding site [ion binding]; other site
866913011737	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866913011738	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
866913011739	exonuclease VIII; Reviewed; Region: PRK09709
866913011740	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
866913011741	RecT family; Region: RecT; pfam03837
866913011742	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
866913011743	integrase; Provisional; Region: PRK09692
866913011744	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
866913011745	active site
866913011746	Int/Topo IB signature motif; other site
866913011747	SoxR reducing system protein RseC; Provisional; Region: PRK10862
866913011748	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
866913011749	anti-sigma E factor; Provisional; Region: rseB; PRK09455
866913011750	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
866913011751	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
866913011752	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
866913011753	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
866913011754	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866913011755	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866913011756	DNA binding residues [nucleotide binding]
866913011757	L-aspartate oxidase; Provisional; Region: PRK09077
866913011758	L-aspartate oxidase; Provisional; Region: PRK06175
866913011759	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
866913011760	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
866913011761	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913011762	S-adenosylmethionine binding site [chemical binding]; other site
866913011763	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
866913011764	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866913011765	ATP binding site [chemical binding]; other site
866913011766	Mg++ binding site [ion binding]; other site
866913011767	motif III; other site
866913011768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913011769	nucleotide binding region [chemical binding]; other site
866913011770	ATP-binding site [chemical binding]; other site
866913011771	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913011772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913011773	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866913011774	dimerization interface [polypeptide binding]; other site
866913011775	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
866913011776	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
866913011777	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
866913011778	ligand binding site [chemical binding]; other site
866913011779	active site
866913011780	UGI interface [polypeptide binding]; other site
866913011781	catalytic site [active]
866913011782	putative methyltransferase; Provisional; Region: PRK10864
866913011783	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
866913011784	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866913011785	thioredoxin 2; Provisional; Region: PRK10996
866913011786	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
866913011787	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866913011788	catalytic residues [active]
866913011789	Uncharacterized conserved protein [Function unknown]; Region: COG3148
866913011790	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
866913011791	CoA binding domain; Region: CoA_binding_2; pfam13380
866913011792	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
866913011793	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
866913011794	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866913011795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913011796	Coenzyme A binding pocket [chemical binding]; other site
866913011797	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
866913011798	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
866913011799	domain interface [polypeptide binding]; other site
866913011800	putative active site [active]
866913011801	catalytic site [active]
866913011802	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
866913011803	domain interface [polypeptide binding]; other site
866913011804	putative active site [active]
866913011805	catalytic site [active]
866913011806	lipoprotein; Provisional; Region: PRK10759
866913011807	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
866913011808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913011809	putative substrate translocation pore; other site
866913011810	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
866913011811	protein disaggregation chaperone; Provisional; Region: PRK10865
866913011812	Clp amino terminal domain; Region: Clp_N; pfam02861
866913011813	Clp amino terminal domain; Region: Clp_N; pfam02861
866913011814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913011815	Walker A motif; other site
866913011816	ATP binding site [chemical binding]; other site
866913011817	Walker B motif; other site
866913011818	arginine finger; other site
866913011819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913011820	Walker A motif; other site
866913011821	ATP binding site [chemical binding]; other site
866913011822	Walker B motif; other site
866913011823	arginine finger; other site
866913011824	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866913011825	hypothetical protein; Provisional; Region: PRK10723
866913011826	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
866913011827	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
866913011828	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866913011829	RNA binding surface [nucleotide binding]; other site
866913011830	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866913011831	active site
866913011832	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
866913011833	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
866913011834	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
866913011835	30S subunit binding site; other site
866913011836	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
866913011837	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
866913011838	Prephenate dehydratase; Region: PDT; pfam00800
866913011839	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
866913011840	putative L-Phe binding site [chemical binding]; other site
866913011841	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
866913011842	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
866913011843	Chorismate mutase type II; Region: CM_2; cl00693
866913011844	prephenate dehydrogenase; Validated; Region: PRK08507
866913011845	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
866913011846	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
866913011847	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
866913011848	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
866913011849	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913011850	metal binding site [ion binding]; metal-binding site
866913011851	active site
866913011852	I-site; other site
866913011853	integrase; Provisional; Region: int; PHA02601
866913011854	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866913011855	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866913011856	active site
866913011857	DNA binding site [nucleotide binding]
866913011858	Int/Topo IB signature motif; other site
866913011859	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
866913011860	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
866913011861	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
866913011862	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
866913011863	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
866913011864	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
866913011865	DksA-like zinc finger domain containing protein; Region: PHA00080
866913011866	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
866913011867	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
866913011868	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
866913011869	DinI-like family; Region: DinI; pfam06183
866913011870	portal vertex protein; Provisional; Region: Q; PHA02536
866913011871	Phage portal protein; Region: Phage_portal; pfam04860
866913011872	terminase ATPase subunit; Provisional; Region: P; PHA02535
866913011873	terminase ATPase subunit; Provisional; Region: P; PHA02535
866913011874	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
866913011875	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
866913011876	Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125
866913011877	terminase endonuclease subunit; Provisional; Region: M; PHA02537
866913011878	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
866913011879	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
866913011880	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
866913011881	Phage holin family 2; Region: Phage_holin_2; pfam04550
866913011882	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
866913011883	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913011884	catalytic residue [active]
866913011885	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
866913011886	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
866913011887	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
866913011888	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
866913011889	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
866913011890	baseplate wedge subunit; Provisional; Region: W; PHA02516
866913011891	baseplate assembly protein; Provisional; Region: J; PHA02568
866913011892	phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634
866913011893	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
866913011894	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
866913011895	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
866913011896	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
866913011897	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913011898	major tail sheath protein; Provisional; Region: FI; PHA02560
866913011899	major tail tube protein; Provisional; Region: FII; PHA02600
866913011900	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
866913011901	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
866913011902	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
866913011903	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
866913011904	tail protein; Provisional; Region: D; PHA02561
866913011905	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
866913011906	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
866913011907	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
866913011908	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
866913011909	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
866913011910	RimM N-terminal domain; Region: RimM; pfam01782
866913011911	PRC-barrel domain; Region: PRC; pfam05239
866913011912	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
866913011913	signal recognition particle protein; Provisional; Region: PRK10867
866913011914	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
866913011915	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
866913011916	P loop; other site
866913011917	GTP binding site [chemical binding]; other site
866913011918	Signal peptide binding domain; Region: SRP_SPB; pfam02978
866913011919	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
866913011920	hypothetical protein; Provisional; Region: PRK11573
866913011921	Domain of unknown function DUF21; Region: DUF21; pfam01595
866913011922	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866913011923	Transporter associated domain; Region: CorC_HlyC; smart01091
866913011924	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
866913011925	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
866913011926	dimer interface [polypeptide binding]; other site
866913011927	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
866913011928	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
866913011929	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
866913011930	recombination and repair protein; Provisional; Region: PRK10869
866913011931	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866913011932	Walker A/P-loop; other site
866913011933	ATP binding site [chemical binding]; other site
866913011934	Q-loop/lid; other site
866913011935	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866913011936	ABC transporter signature motif; other site
866913011937	Walker B; other site
866913011938	D-loop; other site
866913011939	H-loop/switch region; other site
866913011940	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
866913011941	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
866913011942	hypothetical protein; Validated; Region: PRK01777
866913011943	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
866913011944	putative coenzyme Q binding site [chemical binding]; other site
866913011945	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
866913011946	SmpB-tmRNA interface; other site
866913011947	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011948	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011949	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011950	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011951	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011952	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011953	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011954	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011955	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011956	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011957	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011958	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913011959	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011960	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011961	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
866913011962	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011963	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
866913011964	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
866913011965	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
866913011966	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
866913011967	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913011968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913011969	Walker A/P-loop; other site
866913011970	ATP binding site [chemical binding]; other site
866913011971	Q-loop/lid; other site
866913011972	ABC transporter signature motif; other site
866913011973	Walker B; other site
866913011974	D-loop; other site
866913011975	H-loop/switch region; other site
866913011976	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
866913011977	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913011978	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
866913011979	hypothetical protein; Provisional; Region: PRK09951
866913011980	Y-family of DNA polymerases; Region: PolY; cl12025
866913011981	DNA binding site [nucleotide binding]
866913011982	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
866913011983	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913011984	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
866913011985	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
866913011986	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
866913011987	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
866913011988	catalytic residues [active]
866913011989	catalytic nucleophile [active]
866913011990	Presynaptic Site I dimer interface [polypeptide binding]; other site
866913011991	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
866913011992	Synaptic Flat tetramer interface [polypeptide binding]; other site
866913011993	Synaptic Site I dimer interface [polypeptide binding]; other site
866913011994	DNA binding site [nucleotide binding]
866913011995	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
866913011996	DNA-binding interface [nucleotide binding]; DNA binding site
866913011997	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
866913011998	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
866913011999	homodimer interface [polypeptide binding]; other site
866913012000	active site
866913012001	TDP-binding site; other site
866913012002	acceptor substrate-binding pocket; other site
866913012003	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913012004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913012005	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866913012006	Walker A/P-loop; other site
866913012007	ATP binding site [chemical binding]; other site
866913012008	Q-loop/lid; other site
866913012009	ABC transporter signature motif; other site
866913012010	Walker B; other site
866913012011	D-loop; other site
866913012012	H-loop/switch region; other site
866913012013	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866913012014	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866913012015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866913012016	Walker A/P-loop; other site
866913012017	ATP binding site [chemical binding]; other site
866913012018	Q-loop/lid; other site
866913012019	ABC transporter signature motif; other site
866913012020	Walker B; other site
866913012021	D-loop; other site
866913012022	H-loop/switch region; other site
866913012023	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
866913012024	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
866913012025	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
866913012026	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
866913012027	outer membrane receptor FepA; Provisional; Region: PRK13528
866913012028	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
866913012029	N-terminal plug; other site
866913012030	ligand-binding site [chemical binding]; other site
866913012031	secreted effector protein PipB2; Provisional; Region: PRK15196
866913012032	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913012033	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913012034	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913012035	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913012036	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
866913012037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
866913012038	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
866913012039	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
866913012040	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
866913012041	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
866913012042	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866913012043	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
866913012044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913012045	dimer interface [polypeptide binding]; other site
866913012046	phosphorylation site [posttranslational modification]
866913012047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913012048	ATP binding site [chemical binding]; other site
866913012049	Mg2+ binding site [ion binding]; other site
866913012050	G-X-G motif; other site
866913012051	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
866913012052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913012053	active site
866913012054	phosphorylation site [posttranslational modification]
866913012055	intermolecular recognition site; other site
866913012056	dimerization interface [polypeptide binding]; other site
866913012057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913012058	DNA binding site [nucleotide binding]
866913012059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
866913012060	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
866913012061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
866913012062	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
866913012063	substrate binding pocket [chemical binding]; other site
866913012064	active site
866913012065	iron coordination sites [ion binding]; other site
866913012066	Predicted dehydrogenase [General function prediction only]; Region: COG0579
866913012067	hydroxyglutarate oxidase; Provisional; Region: PRK11728
866913012068	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
866913012069	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
866913012070	tetramerization interface [polypeptide binding]; other site
866913012071	NAD(P) binding site [chemical binding]; other site
866913012072	catalytic residues [active]
866913012073	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
866913012074	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866913012075	inhibitor-cofactor binding pocket; inhibition site
866913012076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913012077	catalytic residue [active]
866913012078	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
866913012079	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
866913012080	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913012081	DNA-binding site [nucleotide binding]; DNA binding site
866913012082	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
866913012083	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
866913012084	bacterial OsmY and nodulation domain; Region: BON; smart00749
866913012085	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913012086	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
866913012087	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866913012088	dimerization interface [polypeptide binding]; other site
866913012089	putative DNA binding site [nucleotide binding]; other site
866913012090	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866913012091	putative Zn2+ binding site [ion binding]; other site
866913012092	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
866913012093	active site residue [active]
866913012094	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
866913012095	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
866913012096	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
866913012097	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
866913012098	hypothetical protein; Provisional; Region: PRK10556
866913012099	hypothetical protein; Provisional; Region: PRK10132
866913012100	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
866913012101	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913012102	DNA-binding site [nucleotide binding]; DNA binding site
866913012103	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866913012104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913012105	homodimer interface [polypeptide binding]; other site
866913012106	catalytic residue [active]
866913012107	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
866913012108	Uncharacterized conserved protein [Function unknown]; Region: COG2128
866913012109	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
866913012110	catalytic residues [active]
866913012111	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
866913012112	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
866913012113	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
866913012114	Class I ribonucleotide reductase; Region: RNR_I; cd01679
866913012115	active site
866913012116	dimer interface [polypeptide binding]; other site
866913012117	catalytic residues [active]
866913012118	effector binding site; other site
866913012119	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
866913012120	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
866913012121	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
866913012122	dimer interface [polypeptide binding]; other site
866913012123	putative radical transfer pathway; other site
866913012124	diiron center [ion binding]; other site
866913012125	tyrosyl radical; other site
866913012126	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
866913012127	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
866913012128	Walker A/P-loop; other site
866913012129	ATP binding site [chemical binding]; other site
866913012130	Q-loop/lid; other site
866913012131	ABC transporter signature motif; other site
866913012132	Walker B; other site
866913012133	D-loop; other site
866913012134	H-loop/switch region; other site
866913012135	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
866913012136	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
866913012137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866913012138	dimer interface [polypeptide binding]; other site
866913012139	conserved gate region; other site
866913012140	putative PBP binding loops; other site
866913012141	ABC-ATPase subunit interface; other site
866913012142	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
866913012143	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
866913012144	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866913012145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012146	transcriptional repressor MprA; Provisional; Region: PRK10870
866913012147	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866913012148	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
866913012149	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913012150	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913012151	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
866913012152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012153	putative substrate translocation pore; other site
866913012154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012155	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
866913012156	S-ribosylhomocysteinase; Provisional; Region: PRK02260
866913012157	glutamate--cysteine ligase; Provisional; Region: PRK02107
866913012158	Predicted membrane protein [Function unknown]; Region: COG1238
866913012159	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
866913012160	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866913012161	motif II; other site
866913012162	carbon storage regulator; Provisional; Region: PRK01712
866913012163	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
866913012164	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
866913012165	motif 1; other site
866913012166	active site
866913012167	motif 2; other site
866913012168	motif 3; other site
866913012169	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
866913012170	DHHA1 domain; Region: DHHA1; pfam02272
866913012171	recombination regulator RecX; Reviewed; Region: recX; PRK00117
866913012172	recombinase A; Provisional; Region: recA; PRK09354
866913012173	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
866913012174	hexamer interface [polypeptide binding]; other site
866913012175	Walker A motif; other site
866913012176	ATP binding site [chemical binding]; other site
866913012177	Walker B motif; other site
866913012178	hypothetical protein; Validated; Region: PRK03661
866913012179	Transglycosylase SLT domain; Region: SLT_2; pfam13406
866913012180	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913012181	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913012182	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
866913012183	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
866913012184	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
866913012185	Nucleoside recognition; Region: Gate; pfam07670
866913012186	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
866913012187	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
866913012188	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
866913012189	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
866913012190	putative NAD(P) binding site [chemical binding]; other site
866913012191	active site
866913012192	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
866913012193	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
866913012194	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866913012195	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913012196	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
866913012197	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
866913012198	putative active site [active]
866913012199	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
866913012200	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
866913012201	GAF domain; Region: GAF; pfam01590
866913012202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913012203	Walker A motif; other site
866913012204	ATP binding site [chemical binding]; other site
866913012205	Walker B motif; other site
866913012206	arginine finger; other site
866913012207	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
866913012208	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866913012209	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866913012210	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
866913012211	iron binding site [ion binding]; other site
866913012212	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
866913012213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913012214	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913012215	Acylphosphatase; Region: Acylphosphatase; pfam00708
866913012216	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
866913012217	HypF finger; Region: zf-HYPF; pfam07503
866913012218	HypF finger; Region: zf-HYPF; pfam07503
866913012219	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
866913012220	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
866913012221	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
866913012222	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
866913012223	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
866913012224	nickel binding site [ion binding]; other site
866913012225	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
866913012226	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
866913012227	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
866913012228	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866913012229	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
866913012230	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
866913012231	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
866913012232	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
866913012233	NADH dehydrogenase; Region: NADHdh; cl00469
866913012234	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
866913012235	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
866913012236	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
866913012237	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
866913012238	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
866913012239	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
866913012240	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
866913012241	hydrogenase assembly chaperone; Provisional; Region: PRK10409
866913012242	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
866913012243	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
866913012244	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
866913012245	dimerization interface [polypeptide binding]; other site
866913012246	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
866913012247	ATP binding site [chemical binding]; other site
866913012248	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
866913012249	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
866913012250	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
866913012251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913012252	Walker A motif; other site
866913012253	ATP binding site [chemical binding]; other site
866913012254	Walker B motif; other site
866913012255	arginine finger; other site
866913012256	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866913012257	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
866913012258	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
866913012259	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
866913012260	metal binding site [ion binding]; metal-binding site
866913012261	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
866913012262	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
866913012263	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
866913012264	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913012265	ABC-ATPase subunit  interface; other site
866913012266	dimer interface [polypeptide binding]; other site
866913012267	putative PBP binding regions; other site
866913012268	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
866913012269	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866913012270	ABC-ATPase subunit  interface; other site
866913012271	dimer interface [polypeptide binding]; other site
866913012272	putative PBP binding regions; other site
866913012273	transcriptional activator SprB; Provisional; Region: PRK15320
866913012274	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
866913012275	transcriptional regulator SirC; Provisional; Region: PRK15044
866913012276	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913012277	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
866913012278	invasion protein OrgB; Provisional; Region: PRK15322
866913012279	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
866913012280	invasion protein OrgA; Provisional; Region: PRK15323
866913012281	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
866913012282	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
866913012283	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
866913012284	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
866913012285	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
866913012286	transcriptional regulator HilD; Provisional; Region: PRK15185
866913012287	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913012288	invasion protein regulator; Provisional; Region: PRK12370
866913012289	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913012290	DNA binding site [nucleotide binding]
866913012291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866913012292	binding surface
866913012293	TPR motif; other site
866913012294	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866913012295	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913012296	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913012297	catalytic residue [active]
866913012298	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
866913012299	SicP binding; Region: SicP-binding; pfam09119
866913012300	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
866913012301	switch II binding region; other site
866913012302	Rac1 P-loop interaction site [polypeptide binding]; other site
866913012303	GTP binding residues [chemical binding]; other site
866913012304	switch I binding region; other site
866913012305	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
866913012306	active site
866913012307	chaperone protein SicP; Provisional; Region: PRK15329
866913012308	putative acyl carrier protein IacP; Validated; Region: PRK08172
866913012309	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
866913012310	cell invasion protein SipD; Provisional; Region: PRK15330
866913012311	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
866913012312	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
866913012313	chaperone protein SicA; Provisional; Region: PRK15331
866913012314	Tetratricopeptide repeat; Region: TPR_3; pfam07720
866913012315	Tetratricopeptide repeat; Region: TPR_3; pfam07720
866913012316	type III secretion system protein SpaS; Validated; Region: PRK08156
866913012317	type III secretion system protein SpaR; Provisional; Region: PRK15332
866913012318	type III secretion system protein SpaQ; Provisional; Region: PRK15333
866913012319	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
866913012320	type III secretion system protein SpaO; Validated; Region: PRK08158
866913012321	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
866913012322	antigen presentation protein SpaN; Provisional; Region: PRK15334
866913012323	Surface presentation of antigens protein; Region: SPAN; pfam02510
866913012324	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
866913012325	ATP synthase SpaL; Validated; Region: PRK08149
866913012326	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866913012327	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866913012328	Walker A motif; other site
866913012329	ATP binding site [chemical binding]; other site
866913012330	Walker B motif; other site
866913012331	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
866913012332	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
866913012333	type III secretion system protein InvA; Provisional; Region: PRK15337
866913012334	type III secretion system regulator InvE; Provisional; Region: PRK15338
866913012335	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
866913012336	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
866913012337	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
866913012338	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
866913012339	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
866913012340	transcriptional regulator InvF; Provisional; Region: PRK15340
866913012341	InvH outer membrane lipoprotein; Region: InvH; pfam04741
866913012342	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
866913012343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
866913012344	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
866913012345	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866913012346	active site
866913012347	metal binding site [ion binding]; metal-binding site
866913012348	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
866913012349	MutS domain I; Region: MutS_I; pfam01624
866913012350	MutS domain II; Region: MutS_II; pfam05188
866913012351	MutS domain III; Region: MutS_III; pfam05192
866913012352	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
866913012353	Walker A/P-loop; other site
866913012354	ATP binding site [chemical binding]; other site
866913012355	Q-loop/lid; other site
866913012356	ABC transporter signature motif; other site
866913012357	Walker B; other site
866913012358	D-loop; other site
866913012359	H-loop/switch region; other site
866913012360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
866913012361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012362	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866913012363	putative substrate translocation pore; other site
866913012364	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913012365	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913012366	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
866913012367	putative effector binding pocket; other site
866913012368	dimerization interface [polypeptide binding]; other site
866913012369	GntP family permease; Region: GntP_permease; pfam02447
866913012370	fructuronate transporter; Provisional; Region: PRK10034; cl15264
866913012371	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866913012372	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
866913012373	putative NAD(P) binding site [chemical binding]; other site
866913012374	active site
866913012375	putative substrate binding site [chemical binding]; other site
866913012376	hypothetical protein; Provisional; Region: PRK09989
866913012377	putative aldolase; Validated; Region: PRK08130
866913012378	intersubunit interface [polypeptide binding]; other site
866913012379	active site
866913012380	Zn2+ binding site [ion binding]; other site
866913012381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
866913012382	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
866913012383	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866913012384	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913012385	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866913012386	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913012387	MarR family; Region: MarR_2; cl17246
866913012388	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866913012389	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
866913012390	Flavoprotein; Region: Flavoprotein; pfam02441
866913012391	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
866913012392	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
866913012393	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913012394	Peptidase family M23; Region: Peptidase_M23; pfam01551
866913012395	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
866913012396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913012397	S-adenosylmethionine binding site [chemical binding]; other site
866913012398	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
866913012399	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
866913012400	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
866913012401	Permutation of conserved domain; other site
866913012402	active site
866913012403	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
866913012404	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
866913012405	homotrimer interaction site [polypeptide binding]; other site
866913012406	zinc binding site [ion binding]; other site
866913012407	CDP-binding sites; other site
866913012408	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
866913012409	substrate binding site; other site
866913012410	dimer interface; other site
866913012411	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
866913012412	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
866913012413	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
866913012414	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
866913012415	ligand-binding site [chemical binding]; other site
866913012416	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
866913012417	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
866913012418	CysD dimerization site [polypeptide binding]; other site
866913012419	G1 box; other site
866913012420	putative GEF interaction site [polypeptide binding]; other site
866913012421	GTP/Mg2+ binding site [chemical binding]; other site
866913012422	Switch I region; other site
866913012423	G2 box; other site
866913012424	G3 box; other site
866913012425	Switch II region; other site
866913012426	G4 box; other site
866913012427	G5 box; other site
866913012428	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
866913012429	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
866913012430	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
866913012431	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
866913012432	Active Sites [active]
866913012433	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
866913012434	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
866913012435	metal binding site [ion binding]; metal-binding site
866913012436	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
866913012437	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
866913012438	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
866913012439	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
866913012440	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
866913012441	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
866913012442	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
866913012443	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
866913012444	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
866913012445	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
866913012446	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866913012447	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
866913012448	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
866913012449	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
866913012450	Active Sites [active]
866913012451	sulfite reductase subunit beta; Provisional; Region: PRK13504
866913012452	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
866913012453	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
866913012454	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
866913012455	Flavodoxin; Region: Flavodoxin_1; pfam00258
866913012456	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
866913012457	FAD binding pocket [chemical binding]; other site
866913012458	FAD binding motif [chemical binding]; other site
866913012459	catalytic residues [active]
866913012460	NAD binding pocket [chemical binding]; other site
866913012461	phosphate binding motif [ion binding]; other site
866913012462	beta-alpha-beta structure motif; other site
866913012463	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
866913012464	active site
866913012465	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
866913012466	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
866913012467	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
866913012468	enolase; Provisional; Region: eno; PRK00077
866913012469	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
866913012470	dimer interface [polypeptide binding]; other site
866913012471	metal binding site [ion binding]; metal-binding site
866913012472	substrate binding pocket [chemical binding]; other site
866913012473	CTP synthetase; Validated; Region: pyrG; PRK05380
866913012474	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
866913012475	Catalytic site [active]
866913012476	active site
866913012477	UTP binding site [chemical binding]; other site
866913012478	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
866913012479	active site
866913012480	putative oxyanion hole; other site
866913012481	catalytic triad [active]
866913012482	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
866913012483	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
866913012484	homodimer interface [polypeptide binding]; other site
866913012485	metal binding site [ion binding]; metal-binding site
866913012486	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
866913012487	homodimer interface [polypeptide binding]; other site
866913012488	active site
866913012489	putative chemical substrate binding site [chemical binding]; other site
866913012490	metal binding site [ion binding]; metal-binding site
866913012491	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
866913012492	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
866913012493	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
866913012494	HD domain; Region: HD_4; pfam13328
866913012495	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
866913012496	synthetase active site [active]
866913012497	NTP binding site [chemical binding]; other site
866913012498	metal binding site [ion binding]; metal-binding site
866913012499	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
866913012500	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
866913012501	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
866913012502	TRAM domain; Region: TRAM; pfam01938
866913012503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913012504	S-adenosylmethionine binding site [chemical binding]; other site
866913012505	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
866913012506	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
866913012507	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913012508	dimerization interface [polypeptide binding]; other site
866913012509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913012510	dimer interface [polypeptide binding]; other site
866913012511	phosphorylation site [posttranslational modification]
866913012512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913012513	ATP binding site [chemical binding]; other site
866913012514	Mg2+ binding site [ion binding]; other site
866913012515	G-X-G motif; other site
866913012516	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
866913012517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913012518	active site
866913012519	phosphorylation site [posttranslational modification]
866913012520	intermolecular recognition site; other site
866913012521	dimerization interface [polypeptide binding]; other site
866913012522	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
866913012523	putative binding surface; other site
866913012524	active site
866913012525	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
866913012526	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
866913012527	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
866913012528	active site
866913012529	tetramer interface [polypeptide binding]; other site
866913012530	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
866913012531	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
866913012532	active site
866913012533	tetramer interface [polypeptide binding]; other site
866913012534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012535	D-galactonate transporter; Region: 2A0114; TIGR00893
866913012536	putative substrate translocation pore; other site
866913012537	flavodoxin; Provisional; Region: PRK08105
866913012538	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866913012539	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
866913012540	probable active site [active]
866913012541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
866913012542	SecY interacting protein Syd; Provisional; Region: PRK04968
866913012543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
866913012544	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
866913012545	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
866913012546	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
866913012547	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
866913012548	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
866913012549	serine transporter; Region: stp; TIGR00814
866913012550	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
866913012551	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
866913012552	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
866913012553	flap endonuclease-like protein; Provisional; Region: PRK09482
866913012554	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
866913012555	active site
866913012556	metal binding site 1 [ion binding]; metal-binding site
866913012557	putative 5' ssDNA interaction site; other site
866913012558	metal binding site 3; metal-binding site
866913012559	metal binding site 2 [ion binding]; metal-binding site
866913012560	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
866913012561	putative DNA binding site [nucleotide binding]; other site
866913012562	putative metal binding site [ion binding]; other site
866913012563	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
866913012564	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
866913012565	dimer interface [polypeptide binding]; other site
866913012566	active site
866913012567	metal binding site [ion binding]; metal-binding site
866913012568	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
866913012569	intersubunit interface [polypeptide binding]; other site
866913012570	active site
866913012571	Zn2+ binding site [ion binding]; other site
866913012572	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
866913012573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012574	putative substrate translocation pore; other site
866913012575	L-fucose isomerase; Provisional; Region: fucI; PRK10991
866913012576	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
866913012577	hexamer (dimer of trimers) interface [polypeptide binding]; other site
866913012578	trimer interface [polypeptide binding]; other site
866913012579	substrate binding site [chemical binding]; other site
866913012580	Mn binding site [ion binding]; other site
866913012581	L-fuculokinase; Provisional; Region: PRK10331
866913012582	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866913012583	nucleotide binding site [chemical binding]; other site
866913012584	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
866913012585	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
866913012586	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866913012587	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913012588	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
866913012589	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
866913012590	hypothetical protein; Provisional; Region: PRK10873
866913012591	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
866913012592	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913012593	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
866913012594	dimerization interface [polypeptide binding]; other site
866913012595	substrate binding pocket [chemical binding]; other site
866913012596	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
866913012597	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
866913012598	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
866913012599	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866913012600	catalytic residue [active]
866913012601	CsdA-binding activator; Provisional; Region: PRK15019
866913012602	Predicted permeases [General function prediction only]; Region: RarD; COG2962
866913012603	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
866913012604	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
866913012605	putative ATP binding site [chemical binding]; other site
866913012606	putative substrate interface [chemical binding]; other site
866913012607	murein transglycosylase A; Provisional; Region: mltA; PRK11162
866913012608	murein hydrolase B; Provisional; Region: PRK10760; cl17906
866913012609	MltA specific insert domain; Region: MltA; pfam03562
866913012610	3D domain; Region: 3D; pfam06725
866913012611	AMIN domain; Region: AMIN; pfam11741
866913012612	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
866913012613	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866913012614	active site
866913012615	metal binding site [ion binding]; metal-binding site
866913012616	N-acetylglutamate synthase; Validated; Region: PRK05279
866913012617	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
866913012618	putative feedback inhibition sensing region; other site
866913012619	putative nucleotide binding site [chemical binding]; other site
866913012620	putative substrate binding site [chemical binding]; other site
866913012621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913012622	Coenzyme A binding pocket [chemical binding]; other site
866913012623	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
866913012624	AAA domain; Region: AAA_30; pfam13604
866913012625	Family description; Region: UvrD_C_2; pfam13538
866913012626	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
866913012627	protease3; Provisional; Region: PRK15101
866913012628	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
866913012629	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
866913012630	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
866913012631	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
866913012632	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
866913012633	hypothetical protein; Provisional; Region: PRK10332
866913012634	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
866913012635	hypothetical protein; Provisional; Region: PRK11521
866913012636	hypothetical protein; Provisional; Region: PRK10557
866913012637	hypothetical protein; Provisional; Region: PRK10506
866913012638	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
866913012639	thymidylate synthase; Reviewed; Region: thyA; PRK01827
866913012640	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
866913012641	dimerization interface [polypeptide binding]; other site
866913012642	active site
866913012643	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
866913012644	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
866913012645	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
866913012646	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
866913012647	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866913012648	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866913012649	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
866913012650	putative active site [active]
866913012651	Ap4A binding site [chemical binding]; other site
866913012652	nudix motif; other site
866913012653	putative metal binding site [ion binding]; other site
866913012654	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
866913012655	putative DNA-binding cleft [nucleotide binding]; other site
866913012656	putative DNA clevage site; other site
866913012657	molecular lever; other site
866913012658	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
866913012659	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
866913012660	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913012661	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913012662	active site
866913012663	catalytic tetrad [active]
866913012664	lysophospholipid transporter LplT; Provisional; Region: PRK11195
866913012665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012666	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
866913012667	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
866913012668	putative acyl-acceptor binding pocket; other site
866913012669	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
866913012670	acyl-activating enzyme (AAE) consensus motif; other site
866913012671	putative AMP binding site [chemical binding]; other site
866913012672	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
866913012673	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913012674	DNA binding site [nucleotide binding]
866913012675	domain linker motif; other site
866913012676	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
866913012677	dimerization interface (closed form) [polypeptide binding]; other site
866913012678	ligand binding site [chemical binding]; other site
866913012679	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866913012680	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866913012681	DNA binding site [nucleotide binding]
866913012682	domain linker motif; other site
866913012683	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
866913012684	dimerization interface (closed form) [polypeptide binding]; other site
866913012685	ligand binding site [chemical binding]; other site
866913012686	diaminopimelate decarboxylase; Provisional; Region: PRK11165
866913012687	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
866913012688	active site
866913012689	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866913012690	substrate binding site [chemical binding]; other site
866913012691	catalytic residues [active]
866913012692	dimer interface [polypeptide binding]; other site
866913012693	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
866913012694	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913012695	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913012696	dimerization interface [polypeptide binding]; other site
866913012697	putative racemase; Provisional; Region: PRK10200
866913012698	aspartate racemase; Region: asp_race; TIGR00035
866913012699	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
866913012700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012701	putative substrate translocation pore; other site
866913012702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012703	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
866913012704	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
866913012705	NADP binding site [chemical binding]; other site
866913012706	homodimer interface [polypeptide binding]; other site
866913012707	active site
866913012708	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
866913012709	putative acyltransferase; Provisional; Region: PRK05790
866913012710	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866913012711	dimer interface [polypeptide binding]; other site
866913012712	active site
866913012713	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866913012714	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913012715	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866913012716	dimerization interface [polypeptide binding]; other site
866913012717	Predicted membrane protein [Function unknown]; Region: COG4125
866913012718	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
866913012719	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
866913012720	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
866913012721	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
866913012722	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
866913012723	putative metal binding site [ion binding]; other site
866913012724	putative homodimer interface [polypeptide binding]; other site
866913012725	putative homotetramer interface [polypeptide binding]; other site
866913012726	putative homodimer-homodimer interface [polypeptide binding]; other site
866913012727	putative allosteric switch controlling residues; other site
866913012728	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
866913012729	transcriptional activator SprB; Provisional; Region: PRK15320
866913012730	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600
866913012731	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
866913012732	Fimbrial protein; Region: Fimbrial; pfam00419
866913012733	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
866913012734	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
866913012735	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
866913012736	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
866913012737	PapC N-terminal domain; Region: PapC_N; pfam13954
866913012738	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
866913012739	PapC C-terminal domain; Region: PapC_C; pfam13953
866913012740	fimbrial protein StdA; Provisional; Region: PRK15210
866913012741	hypothetical protein; Provisional; Region: PRK10316
866913012742	YfdX protein; Region: YfdX; pfam10938
866913012743	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
866913012744	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
866913012745	oligomeric interface; other site
866913012746	putative active site [active]
866913012747	homodimer interface [polypeptide binding]; other site
866913012748	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
866913012749	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
866913012750	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
866913012751	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866913012752	Peptidase family M23; Region: Peptidase_M23; pfam01551
866913012753	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
866913012754	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
866913012755	active site
866913012756	metal binding site [ion binding]; metal-binding site
866913012757	nudix motif; other site
866913012758	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
866913012759	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
866913012760	dimer interface [polypeptide binding]; other site
866913012761	putative anticodon binding site; other site
866913012762	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
866913012763	motif 1; other site
866913012764	active site
866913012765	motif 2; other site
866913012766	motif 3; other site
866913012767	This domain is found in peptide chain release factors; Region: PCRF; smart00937
866913012768	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
866913012769	RF-1 domain; Region: RF-1; pfam00472
866913012770	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
866913012771	DHH family; Region: DHH; pfam01368
866913012772	DHHA1 domain; Region: DHHA1; pfam02272
866913012773	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
866913012774	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
866913012775	dimerization domain [polypeptide binding]; other site
866913012776	dimer interface [polypeptide binding]; other site
866913012777	catalytic residues [active]
866913012778	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
866913012779	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
866913012780	active site
866913012781	Int/Topo IB signature motif; other site
866913012782	flavodoxin FldB; Provisional; Region: PRK12359
866913012783	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
866913012784	hypothetical protein; Provisional; Region: PRK10878
866913012785	putative global regulator; Reviewed; Region: PRK09559
866913012786	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
866913012787	hemolysin; Provisional; Region: PRK15087
866913012788	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
866913012789	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
866913012790	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
866913012791	beta-galactosidase; Region: BGL; TIGR03356
866913012792	glycine dehydrogenase; Provisional; Region: PRK05367
866913012793	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
866913012794	tetramer interface [polypeptide binding]; other site
866913012795	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913012796	catalytic residue [active]
866913012797	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
866913012798	tetramer interface [polypeptide binding]; other site
866913012799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913012800	catalytic residue [active]
866913012801	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
866913012802	lipoyl attachment site [posttranslational modification]; other site
866913012803	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
866913012804	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
866913012805	oxidoreductase; Provisional; Region: PRK08013
866913012806	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
866913012807	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
866913012808	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
866913012809	proline aminopeptidase P II; Provisional; Region: PRK10879
866913012810	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
866913012811	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
866913012812	active site
866913012813	hypothetical protein; Reviewed; Region: PRK01736
866913012814	Z-ring-associated protein; Provisional; Region: PRK10972
866913012815	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
866913012816	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
866913012817	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
866913012818	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
866913012819	ligand binding site [chemical binding]; other site
866913012820	NAD binding site [chemical binding]; other site
866913012821	tetramer interface [polypeptide binding]; other site
866913012822	catalytic site [active]
866913012823	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
866913012824	L-serine binding site [chemical binding]; other site
866913012825	ACT domain interface; other site
866913012826	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
866913012827	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866913012828	active site
866913012829	dimer interface [polypeptide binding]; other site
866913012830	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
866913012831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913012832	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
866913012833	putative dimerization interface [polypeptide binding]; other site
866913012834	Uncharacterized conserved protein [Function unknown]; Region: COG2968
866913012835	oxidative stress defense protein; Provisional; Region: PRK11087
866913012836	arginine exporter protein; Provisional; Region: PRK09304
866913012837	mechanosensitive channel MscS; Provisional; Region: PRK10334
866913012838	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866913012839	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
866913012840	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
866913012841	active site
866913012842	intersubunit interface [polypeptide binding]; other site
866913012843	zinc binding site [ion binding]; other site
866913012844	Na+ binding site [ion binding]; other site
866913012845	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
866913012846	Phosphoglycerate kinase; Region: PGK; pfam00162
866913012847	substrate binding site [chemical binding]; other site
866913012848	hinge regions; other site
866913012849	ADP binding site [chemical binding]; other site
866913012850	catalytic site [active]
866913012851	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
866913012852	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
866913012853	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
866913012854	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
866913012855	trimer interface [polypeptide binding]; other site
866913012856	putative Zn binding site [ion binding]; other site
866913012857	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
866913012858	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866913012859	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866913012860	Walker A/P-loop; other site
866913012861	ATP binding site [chemical binding]; other site
866913012862	Q-loop/lid; other site
866913012863	ABC transporter signature motif; other site
866913012864	Walker B; other site
866913012865	D-loop; other site
866913012866	H-loop/switch region; other site
866913012867	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866913012868	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866913012869	Walker A/P-loop; other site
866913012870	ATP binding site [chemical binding]; other site
866913012871	Q-loop/lid; other site
866913012872	ABC transporter signature motif; other site
866913012873	Walker B; other site
866913012874	D-loop; other site
866913012875	H-loop/switch region; other site
866913012876	transketolase; Reviewed; Region: PRK12753
866913012877	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
866913012878	TPP-binding site [chemical binding]; other site
866913012879	dimer interface [polypeptide binding]; other site
866913012880	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866913012881	PYR/PP interface [polypeptide binding]; other site
866913012882	dimer interface [polypeptide binding]; other site
866913012883	TPP binding site [chemical binding]; other site
866913012884	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866913012885	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
866913012886	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
866913012887	agmatinase; Region: agmatinase; TIGR01230
866913012888	oligomer interface [polypeptide binding]; other site
866913012889	putative active site [active]
866913012890	Mn binding site [ion binding]; other site
866913012891	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866913012892	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
866913012893	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
866913012894	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
866913012895	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
866913012896	putative NAD(P) binding site [chemical binding]; other site
866913012897	catalytic Zn binding site [ion binding]; other site
866913012898	structural Zn binding site [ion binding]; other site
866913012899	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
866913012900	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
866913012901	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
866913012902	Transcriptional regulators [Transcription]; Region: FadR; COG2186
866913012903	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913012904	DNA-binding site [nucleotide binding]; DNA binding site
866913012905	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
866913012906	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
866913012907	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
866913012908	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
866913012909	dimer interface [polypeptide binding]; other site
866913012910	active site
866913012911	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866913012912	catalytic residues [active]
866913012913	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
866913012914	Virulence promoting factor; Region: YqgB; pfam11036
866913012915	S-adenosylmethionine synthetase; Validated; Region: PRK05250
866913012916	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
866913012917	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
866913012918	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
866913012919	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
866913012920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012921	putative substrate translocation pore; other site
866913012922	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913012923	hypothetical protein; Provisional; Region: PRK04860
866913012924	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
866913012925	DNA-specific endonuclease I; Provisional; Region: PRK15137
866913012926	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
866913012927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
866913012928	RNA methyltransferase, RsmE family; Region: TIGR00046
866913012929	glutathione synthetase; Provisional; Region: PRK05246
866913012930	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
866913012931	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
866913012932	hypothetical protein; Validated; Region: PRK00228
866913012933	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
866913012934	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
866913012935	Transcriptional regulator [Transcription]; Region: IclR; COG1414
866913012936	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
866913012937	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
866913012938	Walker A motif; other site
866913012939	ATP binding site [chemical binding]; other site
866913012940	Walker B motif; other site
866913012941	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
866913012942	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866913012943	catalytic residue [active]
866913012944	YGGT family; Region: YGGT; pfam02325
866913012945	YGGT family; Region: YGGT; pfam02325
866913012946	hypothetical protein; Validated; Region: PRK05090
866913012947	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
866913012948	active site
866913012949	dimerization interface [polypeptide binding]; other site
866913012950	HemN family oxidoreductase; Provisional; Region: PRK05660
866913012951	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913012952	FeS/SAM binding site; other site
866913012953	HemN C-terminal domain; Region: HemN_C; pfam06969
866913012954	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
866913012955	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
866913012956	homodimer interface [polypeptide binding]; other site
866913012957	active site
866913012958	hypothetical protein; Provisional; Region: PRK10626
866913012959	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
866913012960	hypothetical protein; Provisional; Region: PRK11702
866913012961	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
866913012962	adenine DNA glycosylase; Provisional; Region: PRK10880
866913012963	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866913012964	minor groove reading motif; other site
866913012965	helix-hairpin-helix signature motif; other site
866913012966	substrate binding pocket [chemical binding]; other site
866913012967	active site
866913012968	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
866913012969	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
866913012970	DNA binding and oxoG recognition site [nucleotide binding]
866913012971	oxidative damage protection protein; Provisional; Region: PRK05408
866913012972	murein transglycosylase C; Provisional; Region: mltC; PRK11671
866913012973	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
866913012974	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866913012975	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866913012976	catalytic residue [active]
866913012977	ornithine decarboxylase; Provisional; Region: PRK13578
866913012978	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
866913012979	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
866913012980	homodimer interface [polypeptide binding]; other site
866913012981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913012982	catalytic residue [active]
866913012983	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
866913012984	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
866913012985	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
866913012986	dimer interface [polypeptide binding]; other site
866913012987	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866913012988	metal binding site [ion binding]; metal-binding site
866913012989	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
866913012990	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
866913012991	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
866913012992	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
866913012993	putative active site [active]
866913012994	putative catalytic site [active]
866913012995	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
866913012996	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
866913012997	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913012998	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
866913012999	putative dimerization interface [polypeptide binding]; other site
866913013000	putative substrate binding pocket [chemical binding]; other site
866913013001	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
866913013002	Sulfatase; Region: Sulfatase; pfam00884
866913013003	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
866913013004	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913013005	FeS/SAM binding site; other site
866913013006	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
866913013007	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866913013008	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866913013009	DNA binding residues [nucleotide binding]
866913013010	dimerization interface [polypeptide binding]; other site
866913013011	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
866913013012	Amino acid permease; Region: AA_permease_2; pfam13520
866913013013	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
866913013014	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
866913013015	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
866913013016	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
866913013017	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866913013018	NAD(P) binding site [chemical binding]; other site
866913013019	catalytic residues [active]
866913013020	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
866913013021	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
866913013022	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
866913013023	active site
866913013024	catalytic site [active]
866913013025	Zn binding site [ion binding]; other site
866913013026	tetramer interface [polypeptide binding]; other site
866913013027	Predicted amidohydrolase [General function prediction only]; Region: COG0388
866913013028	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
866913013029	putative active site [active]
866913013030	catalytic triad [active]
866913013031	putative dimer interface [polypeptide binding]; other site
866913013032	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913013033	D-galactonate transporter; Region: 2A0114; TIGR00893
866913013034	putative substrate translocation pore; other site
866913013035	mannonate dehydratase; Provisional; Region: PRK03906
866913013036	mannonate dehydratase; Region: uxuA; TIGR00695
866913013037	D-mannonate oxidoreductase; Provisional; Region: PRK15037
866913013038	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
866913013039	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
866913013040	Glucuronate isomerase; Region: UxaC; pfam02614
866913013041	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
866913013042	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913013043	dimer interface [polypeptide binding]; other site
866913013044	putative CheW interface [polypeptide binding]; other site
866913013045	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
866913013046	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
866913013047	CHAP domain; Region: CHAP; pfam05257
866913013048	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
866913013049	putative S-transferase; Provisional; Region: PRK11752
866913013050	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
866913013051	C-terminal domain interface [polypeptide binding]; other site
866913013052	GSH binding site (G-site) [chemical binding]; other site
866913013053	dimer interface [polypeptide binding]; other site
866913013054	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
866913013055	dimer interface [polypeptide binding]; other site
866913013056	N-terminal domain interface [polypeptide binding]; other site
866913013057	active site
866913013058	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
866913013059	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
866913013060	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
866913013061	putative ligand binding residues [chemical binding]; other site
866913013062	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
866913013063	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
866913013064	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
866913013065	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
866913013066	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
866913013067	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
866913013068	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
866913013069	putative substrate-binding site; other site
866913013070	nickel binding site [ion binding]; other site
866913013071	hydrogenase 2 large subunit; Provisional; Region: PRK10467
866913013072	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
866913013073	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
866913013074	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
866913013075	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
866913013076	4Fe-4S binding domain; Region: Fer4_6; pfam12837
866913013077	hydrogenase 2 small subunit; Provisional; Region: PRK10468
866913013078	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
866913013079	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
866913013080	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
866913013081	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
866913013082	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913013083	dimerization interface [polypeptide binding]; other site
866913013084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913013085	dimer interface [polypeptide binding]; other site
866913013086	putative CheW interface [polypeptide binding]; other site
866913013087	hypothetical protein; Provisional; Region: PRK05208
866913013088	oxidoreductase; Provisional; Region: PRK07985
866913013089	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
866913013090	NAD binding site [chemical binding]; other site
866913013091	metal binding site [ion binding]; metal-binding site
866913013092	active site
866913013093	biopolymer transport protein ExbD; Provisional; Region: PRK11267
866913013094	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
866913013095	biopolymer transport protein ExbB; Provisional; Region: PRK10414
866913013096	cystathionine beta-lyase; Provisional; Region: PRK08114
866913013097	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866913013098	homodimer interface [polypeptide binding]; other site
866913013099	substrate-cofactor binding pocket; other site
866913013100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913013101	catalytic residue [active]
866913013102	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866913013103	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
866913013104	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
866913013105	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
866913013106	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913013107	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913013108	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
866913013109	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
866913013110	dimer interface [polypeptide binding]; other site
866913013111	active site
866913013112	metal binding site [ion binding]; metal-binding site
866913013113	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866913013114	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866913013115	active site
866913013116	catalytic tetrad [active]
866913013117	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
866913013118	nucleotide binding site/active site [active]
866913013119	catalytic residue [active]
866913013120	hypothetical protein; Provisional; Region: PRK01254
866913013121	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
866913013122	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
866913013123	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
866913013124	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
866913013125	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
866913013126	DctM-like transporters; Region: DctM; pfam06808
866913013127	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
866913013128	FtsI repressor; Provisional; Region: PRK10883
866913013129	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
866913013130	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
866913013131	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
866913013132	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
866913013133	putative acyl-acceptor binding pocket; other site
866913013134	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
866913013135	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866913013136	CAP-like domain; other site
866913013137	active site
866913013138	primary dimer interface [polypeptide binding]; other site
866913013139	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866913013140	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866913013141	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866913013142	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
866913013143	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
866913013144	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
866913013145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913013146	active site
866913013147	phosphorylation site [posttranslational modification]
866913013148	intermolecular recognition site; other site
866913013149	dimerization interface [polypeptide binding]; other site
866913013150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866913013151	DNA binding site [nucleotide binding]
866913013152	sensor protein QseC; Provisional; Region: PRK10337
866913013153	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
866913013154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913013155	dimer interface [polypeptide binding]; other site
866913013156	phosphorylation site [posttranslational modification]
866913013157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913013158	ATP binding site [chemical binding]; other site
866913013159	Mg2+ binding site [ion binding]; other site
866913013160	G-X-G motif; other site
866913013161	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
866913013162	Uncharacterized conserved protein [Function unknown]; Region: COG1359
866913013163	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
866913013164	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913013165	ATP binding site [chemical binding]; other site
866913013166	Mg2+ binding site [ion binding]; other site
866913013167	G-X-G motif; other site
866913013168	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866913013169	anchoring element; other site
866913013170	dimer interface [polypeptide binding]; other site
866913013171	ATP binding site [chemical binding]; other site
866913013172	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
866913013173	active site
866913013174	metal binding site [ion binding]; metal-binding site
866913013175	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866913013176	esterase YqiA; Provisional; Region: PRK11071
866913013177	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
866913013178	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866913013179	active site
866913013180	metal binding site [ion binding]; metal-binding site
866913013181	hexamer interface [polypeptide binding]; other site
866913013182	putative dehydrogenase; Provisional; Region: PRK11039
866913013183	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
866913013184	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
866913013185	dimer interface [polypeptide binding]; other site
866913013186	ADP-ribose binding site [chemical binding]; other site
866913013187	active site
866913013188	nudix motif; other site
866913013189	metal binding site [ion binding]; metal-binding site
866913013190	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
866913013191	hypothetical protein; Provisional; Region: PRK11653
866913013192	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
866913013193	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
866913013194	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
866913013195	putative active site [active]
866913013196	metal binding site [ion binding]; metal-binding site
866913013197	zinc transporter ZupT; Provisional; Region: PRK04201
866913013198	ZIP Zinc transporter; Region: Zip; pfam02535
866913013199	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
866913013200	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
866913013201	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
866913013202	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
866913013203	catalytic residues [active]
866913013204	hinge region; other site
866913013205	alpha helical domain; other site
866913013206	putative disulfide oxidoreductase; Provisional; Region: PRK04307
866913013207	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
866913013208	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
866913013209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
866913013210	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
866913013211	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
866913013212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
866913013213	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
866913013214	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
866913013215	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
866913013216	putative ribose interaction site [chemical binding]; other site
866913013217	putative ADP binding site [chemical binding]; other site
866913013218	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
866913013219	active site
866913013220	nucleotide binding site [chemical binding]; other site
866913013221	HIGH motif; other site
866913013222	KMSKS motif; other site
866913013223	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
866913013224	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866913013225	metal binding triad; other site
866913013226	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
866913013227	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866913013228	metal binding triad; other site
866913013229	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
866913013230	Uncharacterized conserved protein [Function unknown]; Region: COG3025
866913013231	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
866913013232	putative active site [active]
866913013233	putative metal binding residues [ion binding]; other site
866913013234	signature motif; other site
866913013235	putative triphosphate binding site [ion binding]; other site
866913013236	CHAD domain; Region: CHAD; pfam05235
866913013237	SH3 domain-containing protein; Provisional; Region: PRK10884
866913013238	Bacterial SH3 domain homologues; Region: SH3b; smart00287
866913013239	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
866913013240	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
866913013241	active site
866913013242	NTP binding site [chemical binding]; other site
866913013243	metal binding triad [ion binding]; metal-binding site
866913013244	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
866913013245	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866913013246	Zn2+ binding site [ion binding]; other site
866913013247	Mg2+ binding site [ion binding]; other site
866913013248	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
866913013249	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
866913013250	homooctamer interface [polypeptide binding]; other site
866913013251	active site
866913013252	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
866913013253	UGMP family protein; Validated; Region: PRK09604
866913013254	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
866913013255	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
866913013256	DNA primase; Validated; Region: dnaG; PRK05667
866913013257	CHC2 zinc finger; Region: zf-CHC2; pfam01807
866913013258	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
866913013259	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
866913013260	active site
866913013261	metal binding site [ion binding]; metal-binding site
866913013262	interdomain interaction site; other site
866913013263	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
866913013264	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
866913013265	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
866913013266	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
866913013267	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
866913013268	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
866913013269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866913013270	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866913013271	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866913013272	DNA binding residues [nucleotide binding]
866913013273	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
866913013274	active site
866913013275	SUMO-1 interface [polypeptide binding]; other site
866913013276	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
866913013277	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
866913013278	FAD binding pocket [chemical binding]; other site
866913013279	FAD binding motif [chemical binding]; other site
866913013280	phosphate binding motif [ion binding]; other site
866913013281	NAD binding pocket [chemical binding]; other site
866913013282	Predicted transcriptional regulators [Transcription]; Region: COG1695
866913013283	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
866913013284	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
866913013285	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866913013286	dimerization interface [polypeptide binding]; other site
866913013287	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
866913013288	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913013289	dimer interface [polypeptide binding]; other site
866913013290	putative CheW interface [polypeptide binding]; other site
866913013291	PAS fold; Region: PAS_3; pfam08447
866913013292	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913013293	putative active site [active]
866913013294	heme pocket [chemical binding]; other site
866913013295	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
866913013296	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866913013297	dimer interface [polypeptide binding]; other site
866913013298	putative CheW interface [polypeptide binding]; other site
866913013299	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
866913013300	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866913013301	inhibitor-cofactor binding pocket; inhibition site
866913013302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913013303	catalytic residue [active]
866913013304	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866913013305	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
866913013306	active site
866913013307	FMN binding site [chemical binding]; other site
866913013308	2,4-decadienoyl-CoA binding site; other site
866913013309	catalytic residue [active]
866913013310	4Fe-4S cluster binding site [ion binding]; other site
866913013311	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
866913013312	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913013313	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
866913013314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913013315	S-adenosylmethionine binding site [chemical binding]; other site
866913013316	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
866913013317	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866913013318	putative active site [active]
866913013319	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866913013320	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866913013321	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
866913013322	serine/threonine transporter SstT; Provisional; Region: PRK13628
866913013323	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866913013324	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866913013325	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
866913013326	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
866913013327	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
866913013328	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
866913013329	Predicted membrane protein [Function unknown]; Region: COG5393
866913013330	YqjK-like protein; Region: YqjK; pfam13997
866913013331	Predicted membrane protein [Function unknown]; Region: COG2259
866913013332	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
866913013333	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
866913013334	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
866913013335	putative dimer interface [polypeptide binding]; other site
866913013336	N-terminal domain interface [polypeptide binding]; other site
866913013337	putative substrate binding pocket (H-site) [chemical binding]; other site
866913013338	Predicted membrane protein [Function unknown]; Region: COG3152
866913013339	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913013340	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
866913013341	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866913013342	dimerization interface [polypeptide binding]; other site
866913013343	Pirin-related protein [General function prediction only]; Region: COG1741
866913013344	Pirin; Region: Pirin; pfam02678
866913013345	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
866913013346	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
866913013347	serine transporter; Region: stp; TIGR00814
866913013348	L-serine dehydratase TdcG; Provisional; Region: PRK15040
866913013349	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
866913013350	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
866913013351	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
866913013352	Pyruvate formate lyase 1; Region: PFL1; cd01678
866913013353	coenzyme A binding site [chemical binding]; other site
866913013354	active site
866913013355	catalytic residues [active]
866913013356	glycine loop; other site
866913013357	propionate/acetate kinase; Provisional; Region: PRK12379
866913013358	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
866913013359	threonine/serine transporter TdcC; Provisional; Region: PRK13629
866913013360	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
866913013361	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
866913013362	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
866913013363	tetramer interface [polypeptide binding]; other site
866913013364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866913013365	catalytic residue [active]
866913013366	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
866913013367	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913013368	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
866913013369	putative substrate binding pocket [chemical binding]; other site
866913013370	putative dimerization interface [polypeptide binding]; other site
866913013371	glycerate kinase I; Provisional; Region: PRK10342
866913013372	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
866913013373	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866913013374	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
866913013375	galactarate dehydratase; Region: galactar-dH20; TIGR03248
866913013376	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
866913013377	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
866913013378	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866913013379	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
866913013380	substrate binding site [chemical binding]; other site
866913013381	ATP binding site [chemical binding]; other site
866913013382	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913013383	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866913013384	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913013385	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
866913013386	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
866913013387	intersubunit interface [polypeptide binding]; other site
866913013388	active site
866913013389	zinc binding site [ion binding]; other site
866913013390	Na+ binding site [ion binding]; other site
866913013391	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
866913013392	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
866913013393	putative substrate binding site [chemical binding]; other site
866913013394	putative ATP binding site [chemical binding]; other site
866913013395	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
866913013396	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
866913013397	putative NAD(P) binding site [chemical binding]; other site
866913013398	catalytic Zn binding site [ion binding]; other site
866913013399	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866913013400	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866913013401	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866913013402	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
866913013403	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
866913013404	putative SAM binding site [chemical binding]; other site
866913013405	putative homodimer interface [polypeptide binding]; other site
866913013406	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866913013407	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
866913013408	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
866913013409	putative ligand binding site [chemical binding]; other site
866913013410	TIGR00252 family protein; Region: TIGR00252
866913013411	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
866913013412	dimer interface [polypeptide binding]; other site
866913013413	active site
866913013414	outer membrane lipoprotein; Provisional; Region: PRK11023
866913013415	BON domain; Region: BON; pfam04972
866913013416	BON domain; Region: BON; pfam04972
866913013417	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
866913013418	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866913013419	NAD binding site [chemical binding]; other site
866913013420	active site
866913013421	intracellular protease, PfpI family; Region: PfpI; TIGR01382
866913013422	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
866913013423	proposed catalytic triad [active]
866913013424	conserved cys residue [active]
866913013425	hypothetical protein; Provisional; Region: PRK03467
866913013426	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
866913013427	GIY-YIG motif/motif A; other site
866913013428	putative active site [active]
866913013429	putative metal binding site [ion binding]; other site
866913013430	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
866913013431	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866913013432	Coenzyme A binding pocket [chemical binding]; other site
866913013433	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
866913013434	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
866913013435	Peptidase family U32; Region: Peptidase_U32; pfam01136
866913013436	putative protease; Provisional; Region: PRK15447
866913013437	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
866913013438	hypothetical protein; Provisional; Region: PRK10508
866913013439	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
866913013440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
866913013441	tryptophan permease; Provisional; Region: PRK10483
866913013442	aromatic amino acid transport protein; Region: araaP; TIGR00837
866913013443	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866913013444	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866913013445	ATP binding site [chemical binding]; other site
866913013446	Mg++ binding site [ion binding]; other site
866913013447	motif III; other site
866913013448	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866913013449	nucleotide binding region [chemical binding]; other site
866913013450	ATP-binding site [chemical binding]; other site
866913013451	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
866913013452	putative RNA binding site [nucleotide binding]; other site
866913013453	lipoprotein NlpI; Provisional; Region: PRK11189
866913013454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866913013455	binding surface
866913013456	TPR motif; other site
866913013457	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
866913013458	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
866913013459	RNase E interface [polypeptide binding]; other site
866913013460	trimer interface [polypeptide binding]; other site
866913013461	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
866913013462	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
866913013463	RNase E interface [polypeptide binding]; other site
866913013464	trimer interface [polypeptide binding]; other site
866913013465	active site
866913013466	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
866913013467	putative nucleic acid binding region [nucleotide binding]; other site
866913013468	G-X-X-G motif; other site
866913013469	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
866913013470	RNA binding site [nucleotide binding]; other site
866913013471	domain interface; other site
866913013472	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
866913013473	16S/18S rRNA binding site [nucleotide binding]; other site
866913013474	S13e-L30e interaction site [polypeptide binding]; other site
866913013475	25S rRNA binding site [nucleotide binding]; other site
866913013476	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
866913013477	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
866913013478	RNA binding site [nucleotide binding]; other site
866913013479	active site
866913013480	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
866913013481	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
866913013482	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
866913013483	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
866913013484	translation initiation factor IF-2; Region: IF-2; TIGR00487
866913013485	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
866913013486	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
866913013487	G1 box; other site
866913013488	putative GEF interaction site [polypeptide binding]; other site
866913013489	GTP/Mg2+ binding site [chemical binding]; other site
866913013490	Switch I region; other site
866913013491	G2 box; other site
866913013492	G3 box; other site
866913013493	Switch II region; other site
866913013494	G4 box; other site
866913013495	G5 box; other site
866913013496	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
866913013497	Translation-initiation factor 2; Region: IF-2; pfam11987
866913013498	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
866913013499	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
866913013500	NusA N-terminal domain; Region: NusA_N; pfam08529
866913013501	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
866913013502	RNA binding site [nucleotide binding]; other site
866913013503	homodimer interface [polypeptide binding]; other site
866913013504	NusA-like KH domain; Region: KH_5; pfam13184
866913013505	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
866913013506	G-X-X-G motif; other site
866913013507	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
866913013508	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
866913013509	ribosome maturation protein RimP; Reviewed; Region: PRK00092
866913013510	Sm and related proteins; Region: Sm_like; cl00259
866913013511	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
866913013512	putative oligomer interface [polypeptide binding]; other site
866913013513	putative RNA binding site [nucleotide binding]; other site
866913013514	argininosuccinate synthase; Validated; Region: PRK05370
866913013515	argininosuccinate synthase; Provisional; Region: PRK13820
866913013516	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
866913013517	Preprotein translocase SecG subunit; Region: SecG; pfam03840
866913013518	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
866913013519	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
866913013520	active site
866913013521	substrate binding site [chemical binding]; other site
866913013522	metal binding site [ion binding]; metal-binding site
866913013523	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
866913013524	dihydropteroate synthase; Region: DHPS; TIGR01496
866913013525	substrate binding pocket [chemical binding]; other site
866913013526	dimer interface [polypeptide binding]; other site
866913013527	inhibitor binding site; inhibition site
866913013528	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866913013529	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
866913013530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866913013531	Walker A motif; other site
866913013532	ATP binding site [chemical binding]; other site
866913013533	Walker B motif; other site
866913013534	arginine finger; other site
866913013535	Peptidase family M41; Region: Peptidase_M41; pfam01434
866913013536	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
866913013537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913013538	S-adenosylmethionine binding site [chemical binding]; other site
866913013539	RNA-binding protein YhbY; Provisional; Region: PRK10343
866913013540	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
866913013541	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
866913013542	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
866913013543	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
866913013544	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
866913013545	GTPase CgtA; Reviewed; Region: obgE; PRK12298
866913013546	GTP1/OBG; Region: GTP1_OBG; pfam01018
866913013547	Obg GTPase; Region: Obg; cd01898
866913013548	G1 box; other site
866913013549	GTP/Mg2+ binding site [chemical binding]; other site
866913013550	Switch I region; other site
866913013551	G2 box; other site
866913013552	G3 box; other site
866913013553	Switch II region; other site
866913013554	G4 box; other site
866913013555	G5 box; other site
866913013556	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866913013557	EamA-like transporter family; Region: EamA; pfam00892
866913013558	EamA-like transporter family; Region: EamA; pfam00892
866913013559	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
866913013560	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
866913013561	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
866913013562	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
866913013563	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
866913013564	substrate binding pocket [chemical binding]; other site
866913013565	chain length determination region; other site
866913013566	substrate-Mg2+ binding site; other site
866913013567	catalytic residues [active]
866913013568	aspartate-rich region 1; other site
866913013569	active site lid residues [active]
866913013570	aspartate-rich region 2; other site
866913013571	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
866913013572	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
866913013573	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
866913013574	hinge; other site
866913013575	active site
866913013576	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
866913013577	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
866913013578	anti sigma factor interaction site; other site
866913013579	regulatory phosphorylation site [posttranslational modification]; other site
866913013580	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
866913013581	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
866913013582	mce related protein; Region: MCE; pfam02470
866913013583	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
866913013584	conserved hypothetical integral membrane protein; Region: TIGR00056
866913013585	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
866913013586	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
866913013587	Walker A/P-loop; other site
866913013588	ATP binding site [chemical binding]; other site
866913013589	Q-loop/lid; other site
866913013590	ABC transporter signature motif; other site
866913013591	Walker B; other site
866913013592	D-loop; other site
866913013593	H-loop/switch region; other site
866913013594	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
866913013595	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866913013596	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866913013597	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
866913013598	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
866913013599	putative active site [active]
866913013600	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
866913013601	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
866913013602	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
866913013603	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
866913013604	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
866913013605	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
866913013606	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
866913013607	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
866913013608	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
866913013609	Walker A/P-loop; other site
866913013610	ATP binding site [chemical binding]; other site
866913013611	Q-loop/lid; other site
866913013612	ABC transporter signature motif; other site
866913013613	Walker B; other site
866913013614	D-loop; other site
866913013615	H-loop/switch region; other site
866913013616	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
866913013617	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
866913013618	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
866913013619	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
866913013620	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
866913013621	30S subunit binding site; other site
866913013622	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866913013623	active site
866913013624	phosphorylation site [posttranslational modification]
866913013625	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
866913013626	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866913013627	dimerization domain swap beta strand [polypeptide binding]; other site
866913013628	regulatory protein interface [polypeptide binding]; other site
866913013629	active site
866913013630	regulatory phosphorylation site [posttranslational modification]; other site
866913013631	hypothetical protein; Provisional; Region: PRK10345
866913013632	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
866913013633	Transglycosylase; Region: Transgly; cl17702
866913013634	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
866913013635	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
866913013636	conserved cys residue [active]
866913013637	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
866913013638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866913013639	putative active site [active]
866913013640	heme pocket [chemical binding]; other site
866913013641	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866913013642	dimer interface [polypeptide binding]; other site
866913013643	phosphorylation site [posttranslational modification]
866913013644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866913013645	ATP binding site [chemical binding]; other site
866913013646	Mg2+ binding site [ion binding]; other site
866913013647	G-X-G motif; other site
866913013648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866913013649	active site
866913013650	phosphorylation site [posttranslational modification]
866913013651	intermolecular recognition site; other site
866913013652	dimerization interface [polypeptide binding]; other site
866913013653	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
866913013654	putative binding surface; other site
866913013655	active site
866913013656	radical SAM protein, TIGR01212 family; Region: TIGR01212
866913013657	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866913013658	FeS/SAM binding site; other site
866913013659	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
866913013660	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
866913013661	active site
866913013662	dimer interface [polypeptide binding]; other site
866913013663	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
866913013664	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
866913013665	active site
866913013666	FMN binding site [chemical binding]; other site
866913013667	substrate binding site [chemical binding]; other site
866913013668	3Fe-4S cluster binding site [ion binding]; other site
866913013669	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
866913013670	domain interface; other site
866913013671	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
866913013672	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866913013673	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866913013674	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
866913013675	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
866913013676	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
866913013677	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
866913013678	Na binding site [ion binding]; other site
866913013679	putative substrate binding site [chemical binding]; other site
866913013680	cytosine deaminase; Provisional; Region: PRK09230
866913013681	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
866913013682	active site
866913013683	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
866913013684	N-acetylmannosamine kinase; Provisional; Region: PRK05082
866913013685	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866913013686	nucleotide binding site [chemical binding]; other site
866913013687	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
866913013688	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
866913013689	putative active site cavity [active]
866913013690	putative sialic acid transporter; Provisional; Region: PRK03893
866913013691	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866913013692	putative substrate translocation pore; other site
866913013693	N-acetylneuraminate lyase; Provisional; Region: PRK04147
866913013694	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
866913013695	inhibitor site; inhibition site
866913013696	active site
866913013697	dimer interface [polypeptide binding]; other site
866913013698	catalytic residue [active]
866913013699	transcriptional regulator NanR; Provisional; Region: PRK03837
866913013700	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913013701	DNA-binding site [nucleotide binding]; DNA binding site
866913013702	FCD domain; Region: FCD; pfam07729
866913013703	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
866913013704	stringent starvation protein A; Provisional; Region: sspA; PRK09481
866913013705	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
866913013706	C-terminal domain interface [polypeptide binding]; other site
866913013707	putative GSH binding site (G-site) [chemical binding]; other site
866913013708	dimer interface [polypeptide binding]; other site
866913013709	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
866913013710	dimer interface [polypeptide binding]; other site
866913013711	N-terminal domain interface [polypeptide binding]; other site
866913013712	Family of unknown function (DUF695); Region: DUF695; pfam05117
866913013713	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
866913013714	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
866913013715	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
866913013716	23S rRNA interface [nucleotide binding]; other site
866913013717	L3 interface [polypeptide binding]; other site
866913013718	Predicted ATPase [General function prediction only]; Region: COG1485
866913013719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
866913013720	hypothetical protein; Provisional; Region: PRK11677
866913013721	serine endoprotease; Provisional; Region: PRK10139
866913013722	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866913013723	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866913013724	protein binding site [polypeptide binding]; other site
866913013725	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866913013726	serine endoprotease; Provisional; Region: PRK10898
866913013727	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866913013728	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866913013729	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
866913013730	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
866913013731	oxaloacetate decarboxylase; Provisional; Region: PRK14040
866913013732	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
866913013733	active site
866913013734	catalytic residues [active]
866913013735	metal binding site [ion binding]; metal-binding site
866913013736	homodimer binding site [polypeptide binding]; other site
866913013737	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866913013738	carboxyltransferase (CT) interaction site; other site
866913013739	biotinylation site [posttranslational modification]; other site
866913013740	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
866913013741	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
866913013742	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
866913013743	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
866913013744	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
866913013745	transmembrane helices; other site
866913013746	Transcriptional regulators [Transcription]; Region: GntR; COG1802
866913013747	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913013748	DNA-binding site [nucleotide binding]; DNA binding site
866913013749	FCD domain; Region: FCD; pfam07729
866913013750	Transcriptional regulators [Transcription]; Region: GntR; COG1802
866913013751	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866913013752	DNA-binding site [nucleotide binding]; DNA binding site
866913013753	malate dehydrogenase; Provisional; Region: PRK05086
866913013754	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
866913013755	NAD binding site [chemical binding]; other site
866913013756	dimerization interface [polypeptide binding]; other site
866913013757	Substrate binding site [chemical binding]; other site
866913013758	arginine repressor; Provisional; Region: PRK05066
866913013759	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
866913013760	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
866913013761	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913013762	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
866913013763	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
866913013764	RNAase interaction site [polypeptide binding]; other site
866913013765	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
866913013766	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
866913013767	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
866913013768	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913013769	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913013770	efflux system membrane protein; Provisional; Region: PRK11594
866913013771	transcriptional regulator; Provisional; Region: PRK10632
866913013772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866913013773	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
866913013774	putative effector binding pocket; other site
866913013775	dimerization interface [polypeptide binding]; other site
866913013776	protease TldD; Provisional; Region: tldD; PRK10735
866913013777	hypothetical protein; Provisional; Region: PRK10899
866913013778	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
866913013779	ribonuclease G; Provisional; Region: PRK11712
866913013780	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
866913013781	homodimer interface [polypeptide binding]; other site
866913013782	oligonucleotide binding site [chemical binding]; other site
866913013783	Maf-like protein; Region: Maf; pfam02545
866913013784	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
866913013785	active site
866913013786	dimer interface [polypeptide binding]; other site
866913013787	rod shape-determining protein MreD; Provisional; Region: PRK11060
866913013788	rod shape-determining protein MreC; Region: mreC; TIGR00219
866913013789	rod shape-determining protein MreC; Region: MreC; pfam04085
866913013790	rod shape-determining protein MreB; Provisional; Region: PRK13927
866913013791	MreB and similar proteins; Region: MreB_like; cd10225
866913013792	nucleotide binding site [chemical binding]; other site
866913013793	Mg binding site [ion binding]; other site
866913013794	putative protofilament interaction site [polypeptide binding]; other site
866913013795	RodZ interaction site [polypeptide binding]; other site
866913013796	regulatory protein CsrD; Provisional; Region: PRK11059
866913013797	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913013798	metal binding site [ion binding]; metal-binding site
866913013799	active site
866913013800	I-site; other site
866913013801	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913013802	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
866913013803	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
866913013804	NADP binding site [chemical binding]; other site
866913013805	dimer interface [polypeptide binding]; other site
866913013806	TMAO/DMSO reductase; Reviewed; Region: PRK05363
866913013807	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
866913013808	Moco binding site; other site
866913013809	metal coordination site [ion binding]; other site
866913013810	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
866913013811	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
866913013812	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866913013813	carboxyltransferase (CT) interaction site; other site
866913013814	biotinylation site [posttranslational modification]; other site
866913013815	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
866913013816	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866913013817	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
866913013818	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
866913013819	hypothetical protein; Provisional; Region: PRK10633
866913013820	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
866913013821	Na binding site [ion binding]; other site
866913013822	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
866913013823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
866913013824	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
866913013825	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
866913013826	FMN binding site [chemical binding]; other site
866913013827	active site
866913013828	catalytic residues [active]
866913013829	substrate binding site [chemical binding]; other site
866913013830	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
866913013831	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
866913013832	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
866913013833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866913013834	DNA methylase; Region: N6_N4_Mtase; pfam01555
866913013835	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
866913013836	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
866913013837	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
866913013838	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
866913013839	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866913013840	metal binding site [ion binding]; metal-binding site
866913013841	active site
866913013842	I-site; other site
866913013843	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866913013844	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
866913013845	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866913013846	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
866913013847	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
866913013848	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
866913013849	HlyD family secretion protein; Region: HlyD_3; pfam13437
866913013850	multidrug efflux system protein AcrB; Provisional; Region: PRK15127