-- dump date 20140620_043336 -- class Genbank::misc_feature -- table misc_feature_note -- id note 454166000001 Haemolysin expression modulating protein; Region: HHA; cl11501 454166000002 Staphylococcal nuclease homologues; Region: SNc; smart00318 454166000003 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 454166000004 Catalytic site; other site 454166000005 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 454166000006 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 454166000007 DNA topoisomerase III; Provisional; Region: PRK07726 454166000008 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 454166000009 active site 454166000010 putative interdomain interaction site [polypeptide binding]; other site 454166000011 putative metal-binding site [ion binding]; other site 454166000012 putative nucleotide binding site [chemical binding]; other site 454166000013 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 454166000014 DNA binding groove [nucleotide binding] 454166000015 domain I; other site 454166000016 phosphate binding site [ion binding]; other site 454166000017 domain II; other site 454166000018 domain III; other site 454166000019 nucleotide binding site [chemical binding]; other site 454166000020 catalytic site [active] 454166000021 domain IV; other site 454166000022 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 454166000023 TrbM; Region: TrbM; pfam07424 454166000024 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 454166000025 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 454166000026 Walker A motif; other site 454166000027 ATP binding site [chemical binding]; other site 454166000028 Walker B motif; other site 454166000029 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 454166000030 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 454166000031 ATP binding site [chemical binding]; other site 454166000032 Walker A motif; other site 454166000033 hexamer interface [polypeptide binding]; other site 454166000034 Walker B motif; other site 454166000035 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 454166000036 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 454166000037 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 454166000038 VirB7 interaction site; other site 454166000039 VirB8 protein; Region: VirB8; pfam04335 454166000040 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 454166000041 Type IV secretion system proteins; Region: T4SS; pfam07996 454166000042 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 454166000043 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 454166000044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166000045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166000046 catalytic residue [active] 454166000047 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 454166000048 Initiator Replication protein; Region: Rep_3; pfam01051 454166000049 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 454166000050 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 454166000051 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 454166000052 conjugal transfer protein TraL; Provisional; Region: PRK13886 454166000053 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 454166000054 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 454166000055 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 454166000056 Threonine operon leader 454166000057 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 454166000058 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 454166000059 putative catalytic residues [active] 454166000060 putative nucleotide binding site [chemical binding]; other site 454166000061 putative aspartate binding site [chemical binding]; other site 454166000062 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 454166000063 dimer interface [polypeptide binding]; other site 454166000064 putative threonine allosteric regulatory site; other site 454166000065 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 454166000066 putative threonine allosteric regulatory site; other site 454166000067 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 454166000068 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 454166000069 homoserine kinase; Provisional; Region: PRK01212 454166000070 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 454166000071 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 454166000072 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 454166000073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166000074 catalytic residue [active] 454166000075 hypothetical protein; Validated; Region: PRK02101 454166000076 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 454166000077 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 454166000078 transaldolase-like protein; Provisional; Region: PTZ00411 454166000079 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 454166000080 active site 454166000081 dimer interface [polypeptide binding]; other site 454166000082 catalytic residue [active] 454166000083 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 454166000084 MPT binding site; other site 454166000085 trimer interface [polypeptide binding]; other site 454166000086 hypothetical protein; Provisional; Region: PRK10659 454166000087 hypothetical protein; Provisional; Region: PRK10236 454166000088 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 454166000089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 454166000090 hypothetical protein; Provisional; Region: PRK10154 454166000091 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 454166000092 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 454166000093 nucleotide binding site [chemical binding]; other site 454166000094 chaperone protein DnaJ; Provisional; Region: PRK10767 454166000095 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 454166000096 HSP70 interaction site [polypeptide binding]; other site 454166000097 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 454166000098 substrate binding site [polypeptide binding]; other site 454166000099 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 454166000100 Zn binding sites [ion binding]; other site 454166000101 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 454166000102 dimer interface [polypeptide binding]; other site 454166000103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166000104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166000105 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 454166000106 substrate binding pocket [chemical binding]; other site 454166000107 dimerization interface [polypeptide binding]; other site 454166000108 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 454166000109 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 454166000110 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 454166000111 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 454166000112 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 454166000113 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 454166000114 active site 454166000115 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 454166000116 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 454166000117 aromatic chitin/cellulose binding site residues [chemical binding]; other site 454166000118 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 454166000119 Helix-turn-helix domain; Region: HTH_36; pfam13730 454166000120 fimbrial protein BcfA; Provisional; Region: PRK15187 454166000121 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 454166000122 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166000123 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166000124 outer membrane usher protein; Provisional; Region: PRK15193 454166000125 PapC N-terminal domain; Region: PapC_N; pfam13954 454166000126 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166000127 PapC C-terminal domain; Region: PapC_C; pfam13953 454166000128 fimbrial protein BcfD; Provisional; Region: PRK15189 454166000129 fimbrial protein BcfE; Provisional; Region: PRK15190 454166000130 fimbrial protein BcfF; Provisional; Region: PRK15191 454166000131 fimbrial chaperone BcfG; Provisional; Region: PRK15192 454166000132 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166000133 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166000134 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 454166000135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166000136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166000137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166000138 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 454166000139 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454166000140 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 454166000141 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 454166000142 active site 454166000143 metal binding site [ion binding]; metal-binding site 454166000144 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 454166000145 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 454166000146 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 454166000147 Sulfatase; Region: Sulfatase; pfam00884 454166000148 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 454166000149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166000150 FeS/SAM binding site; other site 454166000151 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454166000152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 454166000153 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454166000154 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 454166000155 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 454166000156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166000157 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 454166000158 putative dimerization interface [polypeptide binding]; other site 454166000159 putative alpha-glucosidase; Provisional; Region: PRK10658 454166000160 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 454166000161 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 454166000162 putative active site [active] 454166000163 putative catalytic site [active] 454166000164 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454166000165 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 454166000166 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 454166000167 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 454166000168 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 454166000169 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 454166000170 active site 454166000171 Riboflavin kinase; Region: Flavokinase; smart00904 454166000172 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 454166000173 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 454166000174 active site 454166000175 HIGH motif; other site 454166000176 nucleotide binding site [chemical binding]; other site 454166000177 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 454166000178 active site 454166000179 KMSKS motif; other site 454166000180 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 454166000181 tRNA binding surface [nucleotide binding]; other site 454166000182 anticodon binding site; other site 454166000183 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 454166000184 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 454166000185 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 454166000186 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454166000187 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 454166000188 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 454166000189 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 454166000190 active site 454166000191 tetramer interface [polypeptide binding]; other site 454166000192 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 454166000193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166000194 active site 454166000195 phosphorylation site [posttranslational modification] 454166000196 intermolecular recognition site; other site 454166000197 dimerization interface [polypeptide binding]; other site 454166000198 Transcriptional regulator; Region: CitT; pfam12431 454166000199 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 454166000200 PAS domain; Region: PAS; smart00091 454166000201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166000202 ATP binding site [chemical binding]; other site 454166000203 Mg2+ binding site [ion binding]; other site 454166000204 G-X-G motif; other site 454166000205 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 454166000206 oxaloacetate decarboxylase; Provisional; Region: PRK14040 454166000207 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 454166000208 active site 454166000209 catalytic residues [active] 454166000210 metal binding site [ion binding]; metal-binding site 454166000211 homodimer binding site [polypeptide binding]; other site 454166000212 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454166000213 carboxyltransferase (CT) interaction site; other site 454166000214 biotinylation site [posttranslational modification]; other site 454166000215 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 454166000216 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 454166000217 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 454166000218 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 454166000219 putative active site [active] 454166000220 (T/H)XGH motif; other site 454166000221 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 454166000222 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 454166000223 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 454166000224 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 454166000225 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 454166000226 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 454166000227 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 454166000228 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 454166000229 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 454166000230 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 454166000231 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 454166000232 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 454166000233 catalytic site [active] 454166000234 subunit interface [polypeptide binding]; other site 454166000235 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 454166000236 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 454166000237 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 454166000238 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 454166000239 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 454166000240 ATP-grasp domain; Region: ATP-grasp_4; cl17255 454166000241 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 454166000242 IMP binding site; other site 454166000243 dimer interface [polypeptide binding]; other site 454166000244 interdomain contacts; other site 454166000245 partial ornithine binding site; other site 454166000246 carnitine operon protein CaiE; Provisional; Region: PRK13627 454166000247 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 454166000248 putative trimer interface [polypeptide binding]; other site 454166000249 putative metal binding site [ion binding]; other site 454166000250 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 454166000251 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454166000252 substrate binding site [chemical binding]; other site 454166000253 oxyanion hole (OAH) forming residues; other site 454166000254 trimer interface [polypeptide binding]; other site 454166000255 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 454166000256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 454166000257 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 454166000258 acyl-activating enzyme (AAE) consensus motif; other site 454166000259 putative AMP binding site [chemical binding]; other site 454166000260 putative active site [active] 454166000261 putative CoA binding site [chemical binding]; other site 454166000262 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 454166000263 CoA-transferase family III; Region: CoA_transf_3; pfam02515 454166000264 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 454166000265 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 454166000266 active site 454166000267 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 454166000268 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 454166000269 Ligand binding site [chemical binding]; other site 454166000270 Electron transfer flavoprotein domain; Region: ETF; pfam01012 454166000271 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 454166000272 Electron transfer flavoprotein domain; Region: ETF; smart00893 454166000273 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 454166000274 putative oxidoreductase FixC; Provisional; Region: PRK10157 454166000275 ferredoxin-like protein FixX; Provisional; Region: PRK15449 454166000276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166000277 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 454166000278 putative substrate translocation pore; other site 454166000279 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454166000280 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166000281 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 454166000282 Sulfatase; Region: Sulfatase; cl17466 454166000283 Sulfatase; Region: Sulfatase; cl17466 454166000284 Sulfatase; Region: Sulfatase; cl17466 454166000285 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 454166000286 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 454166000287 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 454166000288 TrkA-N domain; Region: TrkA_N; pfam02254 454166000289 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 454166000290 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 454166000291 folate binding site [chemical binding]; other site 454166000292 NADP+ binding site [chemical binding]; other site 454166000293 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 454166000294 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 454166000295 active site 454166000296 metal binding site [ion binding]; metal-binding site 454166000297 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 454166000298 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 454166000299 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 454166000300 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 454166000301 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 454166000302 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 454166000303 SurA N-terminal domain; Region: SurA_N; pfam09312 454166000304 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 454166000305 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 454166000306 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 454166000307 OstA-like protein; Region: OstA; pfam03968 454166000308 Organic solvent tolerance protein; Region: OstA_C; pfam04453 454166000309 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 454166000310 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 454166000311 putative metal binding site [ion binding]; other site 454166000312 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 454166000313 HSP70 interaction site [polypeptide binding]; other site 454166000314 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 454166000315 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 454166000316 active site 454166000317 ATP-dependent helicase HepA; Validated; Region: PRK04914 454166000318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166000319 ATP binding site [chemical binding]; other site 454166000320 putative Mg++ binding site [ion binding]; other site 454166000321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166000322 nucleotide binding region [chemical binding]; other site 454166000323 ATP-binding site [chemical binding]; other site 454166000324 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 454166000325 putative active site [active] 454166000326 Uncharacterized conserved protein [Function unknown]; Region: COG1434 454166000327 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454166000328 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454166000329 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454166000330 intersubunit interface [polypeptide binding]; other site 454166000331 active site 454166000332 Zn2+ binding site [ion binding]; other site 454166000333 L-arabinose isomerase; Provisional; Region: PRK02929 454166000334 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 454166000335 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 454166000336 trimer interface [polypeptide binding]; other site 454166000337 putative substrate binding site [chemical binding]; other site 454166000338 putative metal binding site [ion binding]; other site 454166000339 ribulokinase; Provisional; Region: PRK04123 454166000340 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 454166000341 N- and C-terminal domain interface [polypeptide binding]; other site 454166000342 active site 454166000343 MgATP binding site [chemical binding]; other site 454166000344 catalytic site [active] 454166000345 metal binding site [ion binding]; metal-binding site 454166000346 carbohydrate binding site [chemical binding]; other site 454166000347 homodimer interface [polypeptide binding]; other site 454166000348 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 454166000349 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454166000350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166000351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166000352 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454166000353 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 454166000354 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 454166000355 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 454166000356 Walker A/P-loop; other site 454166000357 ATP binding site [chemical binding]; other site 454166000358 Q-loop/lid; other site 454166000359 ABC transporter signature motif; other site 454166000360 Walker B; other site 454166000361 D-loop; other site 454166000362 H-loop/switch region; other site 454166000363 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 454166000364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166000365 dimer interface [polypeptide binding]; other site 454166000366 conserved gate region; other site 454166000367 putative PBP binding loops; other site 454166000368 ABC-ATPase subunit interface; other site 454166000369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166000370 dimer interface [polypeptide binding]; other site 454166000371 conserved gate region; other site 454166000372 putative PBP binding loops; other site 454166000373 ABC-ATPase subunit interface; other site 454166000374 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 454166000375 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 454166000376 transcriptional regulator SgrR; Provisional; Region: PRK13626 454166000377 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 454166000378 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 454166000379 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 454166000380 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 454166000381 substrate binding site [chemical binding]; other site 454166000382 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 454166000383 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 454166000384 substrate binding site [chemical binding]; other site 454166000385 ligand binding site [chemical binding]; other site 454166000386 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 454166000387 tartrate dehydrogenase; Region: TTC; TIGR02089 454166000388 2-isopropylmalate synthase; Validated; Region: PRK00915 454166000389 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 454166000390 active site 454166000391 catalytic residues [active] 454166000392 metal binding site [ion binding]; metal-binding site 454166000393 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 454166000394 Leucine operon leader 454166000395 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 454166000396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166000397 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 454166000398 putative substrate binding pocket [chemical binding]; other site 454166000399 putative dimerization interface [polypeptide binding]; other site 454166000400 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 454166000401 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454166000402 PYR/PP interface [polypeptide binding]; other site 454166000403 dimer interface [polypeptide binding]; other site 454166000404 TPP binding site [chemical binding]; other site 454166000405 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454166000406 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 454166000407 TPP-binding site [chemical binding]; other site 454166000408 dimer interface [polypeptide binding]; other site 454166000409 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 454166000410 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 454166000411 putative valine binding site [chemical binding]; other site 454166000412 dimer interface [polypeptide binding]; other site 454166000413 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 454166000414 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 454166000415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166000416 DNA binding site [nucleotide binding] 454166000417 domain linker motif; other site 454166000418 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 454166000419 dimerization interface [polypeptide binding]; other site 454166000420 ligand binding site [chemical binding]; other site 454166000421 mraZ protein; Region: TIGR00242 454166000422 MraZ protein; Region: MraZ; pfam02381 454166000423 MraZ protein; Region: MraZ; pfam02381 454166000424 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 454166000425 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 454166000426 cell division protein FtsL; Provisional; Region: PRK10772 454166000427 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 454166000428 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454166000429 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454166000430 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 454166000431 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454166000432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454166000433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454166000434 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 454166000435 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454166000436 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454166000437 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454166000438 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 454166000439 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 454166000440 Mg++ binding site [ion binding]; other site 454166000441 putative catalytic motif [active] 454166000442 putative substrate binding site [chemical binding]; other site 454166000443 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 454166000444 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454166000445 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454166000446 cell division protein FtsW; Provisional; Region: PRK10774 454166000447 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 454166000448 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 454166000449 active site 454166000450 homodimer interface [polypeptide binding]; other site 454166000451 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 454166000452 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454166000453 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454166000454 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454166000455 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 454166000456 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 454166000457 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 454166000458 cell division protein FtsQ; Provisional; Region: PRK10775 454166000459 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 454166000460 Cell division protein FtsQ; Region: FtsQ; pfam03799 454166000461 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 454166000462 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166000463 Cell division protein FtsA; Region: FtsA; pfam14450 454166000464 cell division protein FtsZ; Validated; Region: PRK09330 454166000465 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 454166000466 nucleotide binding site [chemical binding]; other site 454166000467 SulA interaction site; other site 454166000468 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 454166000469 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 454166000470 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 454166000471 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 454166000472 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 454166000473 SEC-C motif; Region: SEC-C; pfam02810 454166000474 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 454166000475 active site 454166000476 8-oxo-dGMP binding site [chemical binding]; other site 454166000477 nudix motif; other site 454166000478 metal binding site [ion binding]; metal-binding site 454166000479 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166000480 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166000481 active site 454166000482 catalytic tetrad [active] 454166000483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166000484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166000485 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 454166000486 putative effector binding pocket; other site 454166000487 putative dimerization interface [polypeptide binding]; other site 454166000488 DNA gyrase inhibitor; Reviewed; Region: PRK00418 454166000489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 454166000490 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 454166000491 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 454166000492 CoA-binding site [chemical binding]; other site 454166000493 ATP-binding [chemical binding]; other site 454166000494 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 454166000495 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 454166000496 active site 454166000497 type IV pilin biogenesis protein; Provisional; Region: PRK10573 454166000498 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 454166000499 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 454166000500 hypothetical protein; Provisional; Region: PRK10436 454166000501 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 454166000502 Walker A motif; other site 454166000503 ATP binding site [chemical binding]; other site 454166000504 Walker B motif; other site 454166000505 putative major pilin subunit; Provisional; Region: PRK10574 454166000506 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 454166000507 Pilin (bacterial filament); Region: Pilin; pfam00114 454166000508 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 454166000509 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 454166000510 dimerization interface [polypeptide binding]; other site 454166000511 active site 454166000512 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 454166000513 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 454166000514 amidase catalytic site [active] 454166000515 Zn binding residues [ion binding]; other site 454166000516 substrate binding site [chemical binding]; other site 454166000517 regulatory protein AmpE; Provisional; Region: PRK10987 454166000518 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 454166000519 active site 454166000520 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454166000521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166000522 putative substrate translocation pore; other site 454166000523 aromatic amino acid transporter; Provisional; Region: PRK10238 454166000524 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 454166000525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166000526 DNA-binding site [nucleotide binding]; DNA binding site 454166000527 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454166000528 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 454166000529 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 454166000530 dimer interface [polypeptide binding]; other site 454166000531 TPP-binding site [chemical binding]; other site 454166000532 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 454166000533 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454166000534 E3 interaction surface; other site 454166000535 lipoyl attachment site [posttranslational modification]; other site 454166000536 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454166000537 E3 interaction surface; other site 454166000538 lipoyl attachment site [posttranslational modification]; other site 454166000539 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454166000540 E3 interaction surface; other site 454166000541 lipoyl attachment site [posttranslational modification]; other site 454166000542 e3 binding domain; Region: E3_binding; pfam02817 454166000543 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 454166000544 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 454166000545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454166000546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166000547 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454166000548 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 454166000549 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 454166000550 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 454166000551 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 454166000552 substrate binding site [chemical binding]; other site 454166000553 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 454166000554 substrate binding site [chemical binding]; other site 454166000555 ligand binding site [chemical binding]; other site 454166000556 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 454166000557 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 454166000558 aconitate hydratase 2; Provisional; Region: PLN00094 454166000559 putative inner membrane protein; Provisional; Region: PRK09823 454166000560 Low molecular weight phosphatase family; Region: LMWPc; cl00105 454166000561 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 454166000562 active site 454166000563 hypothetical protein; Provisional; Region: PRK05248 454166000564 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 454166000565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 454166000566 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 454166000567 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 454166000568 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166000569 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454166000570 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166000571 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 454166000572 spermidine synthase; Provisional; Region: PRK00811 454166000573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166000574 S-adenosylmethionine binding site [chemical binding]; other site 454166000575 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 454166000576 multicopper oxidase; Provisional; Region: PRK10965 454166000577 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 454166000578 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 454166000579 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 454166000580 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 454166000581 Trp docking motif [polypeptide binding]; other site 454166000582 putative active site [active] 454166000583 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 454166000584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166000585 active site 454166000586 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 454166000587 active site clefts [active] 454166000588 zinc binding site [ion binding]; other site 454166000589 dimer interface [polypeptide binding]; other site 454166000590 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 454166000591 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454166000592 Walker A/P-loop; other site 454166000593 ATP binding site [chemical binding]; other site 454166000594 Q-loop/lid; other site 454166000595 ABC transporter signature motif; other site 454166000596 Walker B; other site 454166000597 D-loop; other site 454166000598 H-loop/switch region; other site 454166000599 inner membrane transport permease; Provisional; Region: PRK15066 454166000600 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454166000601 putative fimbrial protein StiH; Provisional; Region: PRK15297 454166000602 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 454166000603 PapC N-terminal domain; Region: PapC_N; pfam13954 454166000604 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166000605 PapC C-terminal domain; Region: PapC_C; pfam13953 454166000606 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 454166000607 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166000608 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166000609 fimbrial protein StiA; Provisional; Region: PRK15300 454166000610 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454166000611 active pocket/dimerization site; other site 454166000612 active site 454166000613 phosphorylation site [posttranslational modification] 454166000614 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 454166000615 putative active site [active] 454166000616 putative metal binding site [ion binding]; other site 454166000617 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 454166000618 tetramerization interface [polypeptide binding]; other site 454166000619 active site 454166000620 Pantoate-beta-alanine ligase; Region: PanC; cd00560 454166000621 pantoate--beta-alanine ligase; Region: panC; TIGR00018 454166000622 active site 454166000623 ATP-binding site [chemical binding]; other site 454166000624 pantoate-binding site; other site 454166000625 HXXH motif; other site 454166000626 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 454166000627 oligomerization interface [polypeptide binding]; other site 454166000628 active site 454166000629 metal binding site [ion binding]; metal-binding site 454166000630 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 454166000631 catalytic center binding site [active] 454166000632 ATP binding site [chemical binding]; other site 454166000633 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 454166000634 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 454166000635 active site 454166000636 NTP binding site [chemical binding]; other site 454166000637 metal binding triad [ion binding]; metal-binding site 454166000638 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 454166000639 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 454166000640 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 454166000641 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 454166000642 active site 454166000643 nucleotide binding site [chemical binding]; other site 454166000644 HIGH motif; other site 454166000645 KMSKS motif; other site 454166000646 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 454166000647 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 454166000648 2'-5' RNA ligase; Provisional; Region: PRK15124 454166000649 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 454166000650 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 454166000651 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 454166000652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166000653 ATP binding site [chemical binding]; other site 454166000654 putative Mg++ binding site [ion binding]; other site 454166000655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166000656 nucleotide binding region [chemical binding]; other site 454166000657 ATP-binding site [chemical binding]; other site 454166000658 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 454166000659 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 454166000660 Transglycosylase; Region: Transgly; pfam00912 454166000661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 454166000662 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 454166000663 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166000664 N-terminal plug; other site 454166000665 ligand-binding site [chemical binding]; other site 454166000666 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 454166000667 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454166000668 Walker A/P-loop; other site 454166000669 ATP binding site [chemical binding]; other site 454166000670 Q-loop/lid; other site 454166000671 ABC transporter signature motif; other site 454166000672 Walker B; other site 454166000673 D-loop; other site 454166000674 H-loop/switch region; other site 454166000675 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 454166000676 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 454166000677 siderophore binding site; other site 454166000678 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454166000679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166000680 ABC-ATPase subunit interface; other site 454166000681 dimer interface [polypeptide binding]; other site 454166000682 putative PBP binding regions; other site 454166000683 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166000684 ABC-ATPase subunit interface; other site 454166000685 dimer interface [polypeptide binding]; other site 454166000686 putative PBP binding regions; other site 454166000687 putative fimbrial subunit StfA; Provisional; Region: PRK15283 454166000688 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 454166000689 PapC N-terminal domain; Region: PapC_N; pfam13954 454166000690 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166000691 PapC C-terminal domain; Region: PapC_C; pfam13953 454166000692 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 454166000693 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166000694 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166000695 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 454166000696 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 454166000697 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 454166000698 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 454166000699 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 454166000700 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454166000701 inhibitor-cofactor binding pocket; inhibition site 454166000702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166000703 catalytic residue [active] 454166000704 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 454166000705 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 454166000706 Cl- selectivity filter; other site 454166000707 Cl- binding residues [ion binding]; other site 454166000708 pore gating glutamate residue; other site 454166000709 dimer interface [polypeptide binding]; other site 454166000710 H+/Cl- coupling transport residue; other site 454166000711 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 454166000712 Transposase; Region: DEDD_Tnp_IS110; pfam01548 454166000713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 454166000714 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 454166000715 hypothetical protein; Provisional; Region: PRK10578 454166000716 UPF0126 domain; Region: UPF0126; pfam03458 454166000717 UPF0126 domain; Region: UPF0126; pfam03458 454166000718 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 454166000719 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 454166000720 cobalamin binding residues [chemical binding]; other site 454166000721 putative BtuC binding residues; other site 454166000722 dimer interface [polypeptide binding]; other site 454166000723 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 454166000724 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 454166000725 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 454166000726 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454166000727 Zn2+ binding site [ion binding]; other site 454166000728 Mg2+ binding site [ion binding]; other site 454166000729 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 454166000730 serine endoprotease; Provisional; Region: PRK10942 454166000731 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 454166000732 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454166000733 protein binding site [polypeptide binding]; other site 454166000734 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454166000735 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 454166000736 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 454166000737 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 454166000738 hypothetical protein; Provisional; Region: PRK13677 454166000739 shikimate transporter; Provisional; Region: PRK09952 454166000740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166000741 putative substrate translocation pore; other site 454166000742 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 454166000743 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 454166000744 trimer interface [polypeptide binding]; other site 454166000745 active site 454166000746 substrate binding site [chemical binding]; other site 454166000747 CoA binding site [chemical binding]; other site 454166000748 PII uridylyl-transferase; Provisional; Region: PRK05007 454166000749 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 454166000750 metal binding triad; other site 454166000751 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 454166000752 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454166000753 Zn2+ binding site [ion binding]; other site 454166000754 Mg2+ binding site [ion binding]; other site 454166000755 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 454166000756 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 454166000757 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 454166000758 active site 454166000759 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 454166000760 rRNA interaction site [nucleotide binding]; other site 454166000761 S8 interaction site; other site 454166000762 putative laminin-1 binding site; other site 454166000763 elongation factor Ts; Provisional; Region: tsf; PRK09377 454166000764 UBA/TS-N domain; Region: UBA; pfam00627 454166000765 Elongation factor TS; Region: EF_TS; pfam00889 454166000766 Elongation factor TS; Region: EF_TS; pfam00889 454166000767 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 454166000768 putative nucleotide binding site [chemical binding]; other site 454166000769 uridine monophosphate binding site [chemical binding]; other site 454166000770 homohexameric interface [polypeptide binding]; other site 454166000771 ribosome recycling factor; Reviewed; Region: frr; PRK00083 454166000772 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 454166000773 hinge region; other site 454166000774 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 454166000775 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 454166000776 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 454166000777 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 454166000778 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 454166000779 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 454166000780 catalytic residue [active] 454166000781 putative FPP diphosphate binding site; other site 454166000782 putative FPP binding hydrophobic cleft; other site 454166000783 dimer interface [polypeptide binding]; other site 454166000784 putative IPP diphosphate binding site; other site 454166000785 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 454166000786 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 454166000787 zinc metallopeptidase RseP; Provisional; Region: PRK10779 454166000788 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 454166000789 active site 454166000790 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 454166000791 protein binding site [polypeptide binding]; other site 454166000792 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 454166000793 protein binding site [polypeptide binding]; other site 454166000794 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 454166000795 putative substrate binding region [chemical binding]; other site 454166000796 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 454166000797 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454166000798 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454166000799 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454166000800 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454166000801 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454166000802 Surface antigen; Region: Bac_surface_Ag; pfam01103 454166000803 periplasmic chaperone; Provisional; Region: PRK10780 454166000804 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 454166000805 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 454166000806 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 454166000807 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 454166000808 trimer interface [polypeptide binding]; other site 454166000809 active site 454166000810 UDP-GlcNAc binding site [chemical binding]; other site 454166000811 lipid binding site [chemical binding]; lipid-binding site 454166000812 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 454166000813 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 454166000814 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 454166000815 active site 454166000816 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 454166000817 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 454166000818 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 454166000819 RNA/DNA hybrid binding site [nucleotide binding]; other site 454166000820 active site 454166000821 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 454166000822 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 454166000823 putative active site [active] 454166000824 putative PHP Thumb interface [polypeptide binding]; other site 454166000825 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 454166000826 generic binding surface II; other site 454166000827 generic binding surface I; other site 454166000828 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 454166000829 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 454166000830 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 454166000831 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 454166000832 putative sugar binding site [chemical binding]; other site 454166000833 catalytic residues [active] 454166000834 PKD domain; Region: PKD; pfam00801 454166000835 lysine decarboxylase LdcC; Provisional; Region: PRK15399 454166000836 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454166000837 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454166000838 homodimer interface [polypeptide binding]; other site 454166000839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166000840 catalytic residue [active] 454166000841 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454166000842 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 454166000843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 454166000844 putative metal binding site [ion binding]; other site 454166000845 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 454166000846 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 454166000847 Ligand Binding Site [chemical binding]; other site 454166000848 TilS substrate binding domain; Region: TilS; pfam09179 454166000849 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 454166000850 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 454166000851 hypothetical protein; Provisional; Region: PRK04964 454166000852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 454166000853 hypothetical protein; Provisional; Region: PRK09256 454166000854 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 454166000855 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 454166000856 NlpE N-terminal domain; Region: NlpE; pfam04170 454166000857 prolyl-tRNA synthetase; Provisional; Region: PRK09194 454166000858 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 454166000859 dimer interface [polypeptide binding]; other site 454166000860 motif 1; other site 454166000861 active site 454166000862 motif 2; other site 454166000863 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 454166000864 putative deacylase active site [active] 454166000865 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 454166000866 active site 454166000867 motif 3; other site 454166000868 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 454166000869 anticodon binding site; other site 454166000870 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 454166000871 homodimer interaction site [polypeptide binding]; other site 454166000872 cofactor binding site; other site 454166000873 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 454166000874 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 454166000875 lipoprotein, YaeC family; Region: TIGR00363 454166000876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166000877 dimer interface [polypeptide binding]; other site 454166000878 conserved gate region; other site 454166000879 ABC-ATPase subunit interface; other site 454166000880 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 454166000881 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 454166000882 Walker A/P-loop; other site 454166000883 ATP binding site [chemical binding]; other site 454166000884 Q-loop/lid; other site 454166000885 ABC transporter signature motif; other site 454166000886 Walker B; other site 454166000887 D-loop; other site 454166000888 H-loop/switch region; other site 454166000889 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 454166000890 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 454166000891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166000892 active site 454166000893 motif I; other site 454166000894 motif II; other site 454166000895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166000896 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166000897 active site 454166000898 catalytic tetrad [active] 454166000899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166000900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166000901 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 454166000902 putative effector binding pocket; other site 454166000903 dimerization interface [polypeptide binding]; other site 454166000904 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454166000905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166000906 putative substrate translocation pore; other site 454166000907 hypothetical protein; Provisional; Region: PRK05421 454166000908 putative catalytic site [active] 454166000909 putative metal binding site [ion binding]; other site 454166000910 putative phosphate binding site [ion binding]; other site 454166000911 putative catalytic site [active] 454166000912 putative phosphate binding site [ion binding]; other site 454166000913 putative metal binding site [ion binding]; other site 454166000914 Methyltransferase domain; Region: Methyltransf_23; pfam13489 454166000915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166000916 S-adenosylmethionine binding site [chemical binding]; other site 454166000917 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 454166000918 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166000919 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166000920 catalytic residue [active] 454166000921 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166000922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166000923 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 454166000924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166000925 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 454166000926 RNA/DNA hybrid binding site [nucleotide binding]; other site 454166000927 active site 454166000928 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 454166000929 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 454166000930 active site 454166000931 catalytic site [active] 454166000932 substrate binding site [chemical binding]; other site 454166000933 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 454166000934 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 454166000935 Integrase; Region: Integrase_1; pfam12835 454166000936 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 454166000937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 454166000938 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 454166000939 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 454166000940 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 454166000941 Integrase core domain; Region: rve_3; pfam13683 454166000942 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 454166000943 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 454166000944 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166000945 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166000946 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 454166000947 PapC N-terminal domain; Region: PapC_N; pfam13954 454166000948 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166000949 PapC C-terminal domain; Region: PapC_C; pfam13953 454166000950 putative pilin structural protein SafD; Provisional; Region: PRK15222 454166000951 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 454166000952 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 454166000953 putative active site [active] 454166000954 putative metal binding site [ion binding]; other site 454166000955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166000956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166000957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166000958 dimerization interface [polypeptide binding]; other site 454166000959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454166000960 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 454166000961 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454166000962 dimer interface [polypeptide binding]; other site 454166000963 C-N hydrolase family amidase; Provisional; Region: PRK10438 454166000964 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 454166000965 putative active site [active] 454166000966 catalytic triad [active] 454166000967 dimer interface [polypeptide binding]; other site 454166000968 multimer interface [polypeptide binding]; other site 454166000969 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 454166000970 dimer interface [polypeptide binding]; other site 454166000971 active site 454166000972 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 454166000973 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 454166000974 putative active site [active] 454166000975 putative dimer interface [polypeptide binding]; other site 454166000976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 454166000977 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454166000978 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 454166000979 active site 454166000980 DNA polymerase IV; Validated; Region: PRK02406 454166000981 DNA binding site [nucleotide binding] 454166000982 hypothetical protein; Reviewed; Region: PRK09588 454166000983 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 454166000984 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 454166000985 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 454166000986 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 454166000987 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 454166000988 metal binding site [ion binding]; metal-binding site 454166000989 dimer interface [polypeptide binding]; other site 454166000990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166000991 active site 454166000992 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 454166000993 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 454166000994 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166000995 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454166000996 trimer interface [polypeptide binding]; other site 454166000997 eyelet of channel; other site 454166000998 gamma-glutamyl kinase; Provisional; Region: PRK05429 454166000999 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 454166001000 nucleotide binding site [chemical binding]; other site 454166001001 homotetrameric interface [polypeptide binding]; other site 454166001002 putative phosphate binding site [ion binding]; other site 454166001003 putative allosteric binding site; other site 454166001004 PUA domain; Region: PUA; pfam01472 454166001005 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 454166001006 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 454166001007 putative catalytic cysteine [active] 454166001008 HTH-like domain; Region: HTH_21; pfam13276 454166001009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 454166001010 Integrase core domain; Region: rve; pfam00665 454166001011 Integrase core domain; Region: rve_2; pfam13333 454166001012 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 454166001013 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 454166001014 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 454166001015 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454166001016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001017 putative substrate translocation pore; other site 454166001018 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 454166001019 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 454166001020 hypothetical protein; Provisional; Region: PRK14812 454166001021 substrate binding site [chemical binding]; other site 454166001022 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 454166001023 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 454166001024 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 454166001025 transcriptional activator TtdR; Provisional; Region: PRK09801 454166001026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166001027 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 454166001028 putative effector binding pocket; other site 454166001029 putative dimerization interface [polypeptide binding]; other site 454166001030 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 454166001031 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166001032 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166001033 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 454166001034 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 454166001035 PapC N-terminal domain; Region: PapC_N; pfam13954 454166001036 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166001037 PapC C-terminal domain; Region: PapC_C; pfam13953 454166001038 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 454166001039 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166001040 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166001041 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 454166001042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 454166001043 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454166001044 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166001045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 454166001046 DNA binding site [nucleotide binding] 454166001047 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 454166001048 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 454166001049 DNA binding residues [nucleotide binding] 454166001050 dimerization interface [polypeptide binding]; other site 454166001051 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 454166001052 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 454166001053 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 454166001054 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 454166001055 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166001056 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166001057 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 454166001058 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454166001059 metal-binding site [ion binding] 454166001060 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454166001061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166001062 motif II; other site 454166001063 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 454166001064 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 454166001065 DNA binding residues [nucleotide binding] 454166001066 dimer interface [polypeptide binding]; other site 454166001067 copper binding site [ion binding]; other site 454166001068 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454166001069 metal-binding site [ion binding] 454166001070 putative sialic acid transporter; Region: 2A0112; TIGR00891 454166001071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001072 putative substrate translocation pore; other site 454166001073 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 454166001074 DNA methylase; Region: N6_N4_Mtase; cl17433 454166001075 DNA methylase; Region: N6_N4_Mtase; pfam01555 454166001076 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 454166001077 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 454166001078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 454166001079 VRR-NUC domain; Region: VRR_NUC; pfam08774 454166001080 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 454166001081 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 454166001082 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 454166001083 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 454166001084 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166001085 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 454166001086 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166001087 N-terminal plug; other site 454166001088 ligand-binding site [chemical binding]; other site 454166001089 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 454166001090 hypothetical protein; Provisional; Region: PRK09929 454166001091 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 454166001092 Propionate catabolism activator; Region: PrpR_N; pfam06506 454166001093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166001094 Walker A motif; other site 454166001095 ATP binding site [chemical binding]; other site 454166001096 Walker B motif; other site 454166001097 arginine finger; other site 454166001098 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454166001099 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 454166001100 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 454166001101 tetramer interface [polypeptide binding]; other site 454166001102 active site 454166001103 Mg2+/Mn2+ binding site [ion binding]; other site 454166001104 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 454166001105 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 454166001106 dimer interface [polypeptide binding]; other site 454166001107 active site 454166001108 citrylCoA binding site [chemical binding]; other site 454166001109 oxalacetate/citrate binding site [chemical binding]; other site 454166001110 coenzyme A binding site [chemical binding]; other site 454166001111 catalytic triad [active] 454166001112 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 454166001113 2-methylcitrate dehydratase; Region: prpD; TIGR02330 454166001114 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 454166001115 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 454166001116 acyl-activating enzyme (AAE) consensus motif; other site 454166001117 AMP binding site [chemical binding]; other site 454166001118 active site 454166001119 CoA binding site [chemical binding]; other site 454166001120 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 454166001121 dimer interface [polypeptide binding]; other site 454166001122 active site 454166001123 Schiff base residues; other site 454166001124 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 454166001125 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 454166001126 Autotransporter beta-domain; Region: Autotransporter; pfam03797 454166001127 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 454166001128 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 454166001129 microcin B17 transporter; Reviewed; Region: PRK11098 454166001130 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 454166001131 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 454166001132 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 454166001133 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 454166001134 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 454166001135 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 454166001136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 454166001137 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 454166001138 drug efflux system protein MdtG; Provisional; Region: PRK09874 454166001139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001140 putative substrate translocation pore; other site 454166001141 anti-RssB factor; Provisional; Region: PRK10244 454166001142 hypothetical protein; Provisional; Region: PRK11505 454166001143 psiF repeat; Region: PsiF_repeat; pfam07769 454166001144 psiF repeat; Region: PsiF_repeat; pfam07769 454166001145 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 454166001146 MASE2 domain; Region: MASE2; pfam05230 454166001147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166001148 metal binding site [ion binding]; metal-binding site 454166001149 active site 454166001150 I-site; other site 454166001151 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 454166001152 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 454166001153 hypothetical protein; Validated; Region: PRK00124 454166001154 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 454166001155 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 454166001156 ADP binding site [chemical binding]; other site 454166001157 magnesium binding site [ion binding]; other site 454166001158 putative shikimate binding site; other site 454166001159 hypothetical protein; Provisional; Region: PRK10380 454166001160 hypothetical protein; Provisional; Region: PRK10481 454166001161 hypothetical protein; Provisional; Region: PRK10579 454166001162 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 454166001163 fructokinase; Reviewed; Region: PRK09557 454166001164 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166001165 nucleotide binding site [chemical binding]; other site 454166001166 MFS transport protein AraJ; Provisional; Region: PRK10091 454166001167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001168 putative substrate translocation pore; other site 454166001169 exonuclease subunit SbcC; Provisional; Region: PRK10246 454166001170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166001171 Walker A/P-loop; other site 454166001172 ATP binding site [chemical binding]; other site 454166001173 Q-loop/lid; other site 454166001174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166001175 ABC transporter signature motif; other site 454166001176 Walker B; other site 454166001177 D-loop; other site 454166001178 H-loop/switch region; other site 454166001179 exonuclease subunit SbcD; Provisional; Region: PRK10966 454166001180 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 454166001181 active site 454166001182 metal binding site [ion binding]; metal-binding site 454166001183 DNA binding site [nucleotide binding] 454166001184 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 454166001185 transcriptional regulator PhoB; Provisional; Region: PRK10161 454166001186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166001187 active site 454166001188 phosphorylation site [posttranslational modification] 454166001189 intermolecular recognition site; other site 454166001190 dimerization interface [polypeptide binding]; other site 454166001191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166001192 DNA binding site [nucleotide binding] 454166001193 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 454166001194 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 454166001195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166001196 putative active site [active] 454166001197 heme pocket [chemical binding]; other site 454166001198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166001199 dimer interface [polypeptide binding]; other site 454166001200 phosphorylation site [posttranslational modification] 454166001201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166001202 ATP binding site [chemical binding]; other site 454166001203 Mg2+ binding site [ion binding]; other site 454166001204 G-X-G motif; other site 454166001205 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 454166001206 putative proline-specific permease; Provisional; Region: proY; PRK10580 454166001207 maltodextrin glucosidase; Provisional; Region: PRK10785 454166001208 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 454166001209 homodimer interface [polypeptide binding]; other site 454166001210 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 454166001211 active site 454166001212 homodimer interface [polypeptide binding]; other site 454166001213 catalytic site [active] 454166001214 peroxidase; Provisional; Region: PRK15000 454166001215 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 454166001216 dimer interface [polypeptide binding]; other site 454166001217 decamer (pentamer of dimers) interface [polypeptide binding]; other site 454166001218 catalytic triad [active] 454166001219 peroxidatic and resolving cysteines [active] 454166001220 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 454166001221 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 454166001222 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 454166001223 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 454166001224 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 454166001225 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 454166001226 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 454166001227 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 454166001228 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 454166001229 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 454166001230 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 454166001231 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 454166001232 Protein export membrane protein; Region: SecD_SecF; pfam02355 454166001233 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 454166001234 active site 454166001235 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 454166001236 hypothetical protein; Provisional; Region: PRK11530 454166001237 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 454166001238 ATP cone domain; Region: ATP-cone; pfam03477 454166001239 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 454166001240 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 454166001241 catalytic motif [active] 454166001242 Zn binding site [ion binding]; other site 454166001243 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 454166001244 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 454166001245 homopentamer interface [polypeptide binding]; other site 454166001246 active site 454166001247 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 454166001248 putative RNA binding site [nucleotide binding]; other site 454166001249 thiamine monophosphate kinase; Provisional; Region: PRK05731 454166001250 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 454166001251 ATP binding site [chemical binding]; other site 454166001252 dimerization interface [polypeptide binding]; other site 454166001253 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 454166001254 tetramer interfaces [polypeptide binding]; other site 454166001255 binuclear metal-binding site [ion binding]; other site 454166001256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166001257 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166001258 active site 454166001259 catalytic tetrad [active] 454166001260 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 454166001261 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 454166001262 TPP-binding site; other site 454166001263 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454166001264 PYR/PP interface [polypeptide binding]; other site 454166001265 dimer interface [polypeptide binding]; other site 454166001266 TPP binding site [chemical binding]; other site 454166001267 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454166001268 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 454166001269 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 454166001270 substrate binding pocket [chemical binding]; other site 454166001271 chain length determination region; other site 454166001272 substrate-Mg2+ binding site; other site 454166001273 catalytic residues [active] 454166001274 aspartate-rich region 1; other site 454166001275 active site lid residues [active] 454166001276 aspartate-rich region 2; other site 454166001277 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 454166001278 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 454166001279 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 454166001280 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 454166001281 Ligand Binding Site [chemical binding]; other site 454166001282 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 454166001283 active site residue [active] 454166001284 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 454166001285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166001286 dimer interface [polypeptide binding]; other site 454166001287 conserved gate region; other site 454166001288 putative PBP binding loops; other site 454166001289 ABC-ATPase subunit interface; other site 454166001290 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 454166001291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166001292 Walker A/P-loop; other site 454166001293 ATP binding site [chemical binding]; other site 454166001294 Q-loop/lid; other site 454166001295 ABC transporter signature motif; other site 454166001296 Walker B; other site 454166001297 D-loop; other site 454166001298 H-loop/switch region; other site 454166001299 TOBE domain; Region: TOBE_2; pfam08402 454166001300 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 454166001301 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 454166001302 transcriptional regulator protein; Region: phnR; TIGR03337 454166001303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166001304 DNA-binding site [nucleotide binding]; DNA binding site 454166001305 UTRA domain; Region: UTRA; pfam07702 454166001306 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 454166001307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166001308 catalytic residue [active] 454166001309 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 454166001310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166001311 motif II; other site 454166001312 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 454166001313 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 454166001314 conserved cys residue [active] 454166001315 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 454166001316 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 454166001317 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 454166001318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 454166001319 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 454166001320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166001322 putative substrate translocation pore; other site 454166001323 Sel1-like repeats; Region: SEL1; smart00671 454166001324 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166001325 Sel1 repeat; Region: Sel1; pfam08238 454166001326 Sel1-like repeats; Region: SEL1; smart00671 454166001327 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166001328 Sel1-like repeats; Region: SEL1; smart00671 454166001329 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166001330 Sel1-like repeats; Region: SEL1; smart00671 454166001331 Sel1-like repeats; Region: SEL1; smart00671 454166001332 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 454166001333 UbiA prenyltransferase family; Region: UbiA; pfam01040 454166001334 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 454166001335 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 454166001336 Subunit I/III interface [polypeptide binding]; other site 454166001337 Subunit III/IV interface [polypeptide binding]; other site 454166001338 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 454166001339 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 454166001340 D-pathway; other site 454166001341 Putative ubiquinol binding site [chemical binding]; other site 454166001342 Low-spin heme (heme b) binding site [chemical binding]; other site 454166001343 Putative water exit pathway; other site 454166001344 Binuclear center (heme o3/CuB) [ion binding]; other site 454166001345 K-pathway; other site 454166001346 Putative proton exit pathway; other site 454166001347 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 454166001348 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 454166001349 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 454166001350 muropeptide transporter; Reviewed; Region: ampG; PRK11902 454166001351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001352 putative substrate translocation pore; other site 454166001353 transcriptional regulator BolA; Provisional; Region: PRK11628 454166001354 trigger factor; Provisional; Region: tig; PRK01490 454166001355 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454166001356 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 454166001357 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 454166001358 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 454166001359 oligomer interface [polypeptide binding]; other site 454166001360 active site residues [active] 454166001361 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 454166001362 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 454166001363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166001364 Walker A motif; other site 454166001365 ATP binding site [chemical binding]; other site 454166001366 Walker B motif; other site 454166001367 Iron permease FTR1 family; Region: FTR1; cl00475 454166001368 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 454166001369 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 454166001370 Found in ATP-dependent protease La (LON); Region: LON; smart00464 454166001371 Found in ATP-dependent protease La (LON); Region: LON; smart00464 454166001372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166001373 Walker A motif; other site 454166001374 ATP binding site [chemical binding]; other site 454166001375 Walker B motif; other site 454166001376 arginine finger; other site 454166001377 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 454166001378 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454166001379 IHF dimer interface [polypeptide binding]; other site 454166001380 IHF - DNA interface [nucleotide binding]; other site 454166001381 periplasmic folding chaperone; Provisional; Region: PRK10788 454166001382 SurA N-terminal domain; Region: SurA_N_3; cl07813 454166001383 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 454166001384 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 454166001385 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 454166001386 active site 454166001387 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 454166001388 Ligand Binding Site [chemical binding]; other site 454166001389 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 454166001390 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 454166001391 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 454166001392 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 454166001393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166001394 active site 454166001395 motif I; other site 454166001396 motif II; other site 454166001397 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 454166001398 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 454166001399 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166001400 catalytic residue [active] 454166001401 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 454166001402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166001403 putative DNA binding site [nucleotide binding]; other site 454166001404 putative Zn2+ binding site [ion binding]; other site 454166001405 AsnC family; Region: AsnC_trans_reg; pfam01037 454166001406 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 454166001407 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166001408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166001409 Walker A/P-loop; other site 454166001410 ATP binding site [chemical binding]; other site 454166001411 Q-loop/lid; other site 454166001412 ABC transporter signature motif; other site 454166001413 Walker B; other site 454166001414 D-loop; other site 454166001415 H-loop/switch region; other site 454166001416 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 454166001417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166001418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166001419 Walker A/P-loop; other site 454166001420 ATP binding site [chemical binding]; other site 454166001421 Q-loop/lid; other site 454166001422 ABC transporter signature motif; other site 454166001423 Walker B; other site 454166001424 D-loop; other site 454166001425 H-loop/switch region; other site 454166001426 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 454166001427 Nitrogen regulatory protein P-II; Region: P-II; smart00938 454166001428 ammonium transporter; Provisional; Region: PRK10666 454166001429 acyl-CoA thioesterase II; Provisional; Region: PRK10526 454166001430 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 454166001431 active site 454166001432 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 454166001433 catalytic triad [active] 454166001434 dimer interface [polypeptide binding]; other site 454166001435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 454166001436 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 454166001437 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 454166001438 DNA binding site [nucleotide binding] 454166001439 active site 454166001440 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 454166001441 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454166001442 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166001443 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 454166001444 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 454166001445 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 454166001446 maltose O-acetyltransferase; Provisional; Region: PRK10092 454166001447 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 454166001448 active site 454166001449 substrate binding site [chemical binding]; other site 454166001450 trimer interface [polypeptide binding]; other site 454166001451 CoA binding site [chemical binding]; other site 454166001452 gene expression modulator; Provisional; Region: PRK10945 454166001453 Hha toxicity attenuator; Provisional; Region: PRK10667 454166001454 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 454166001455 Protein export membrane protein; Region: SecD_SecF; cl14618 454166001456 Protein export membrane protein; Region: SecD_SecF; cl14618 454166001457 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 454166001458 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166001459 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 454166001460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166001461 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 454166001462 hypothetical protein; Provisional; Region: PRK11281 454166001463 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 454166001464 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 454166001465 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166001466 Uncharacterized conserved protein [Function unknown]; Region: COG5464 454166001467 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454166001468 hypothetical protein; Provisional; Region: PRK11038 454166001469 primosomal replication protein N''; Provisional; Region: PRK10093 454166001470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454166001471 hypothetical protein; Provisional; Region: PRK10527 454166001472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166001473 active site 454166001474 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 454166001475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166001476 Walker A motif; other site 454166001477 ATP binding site [chemical binding]; other site 454166001478 Walker B motif; other site 454166001479 DNA polymerase III subunit delta'; Validated; Region: PRK08485 454166001480 arginine finger; other site 454166001481 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 454166001482 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 454166001483 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 454166001484 hypothetical protein; Validated; Region: PRK00153 454166001485 recombination protein RecR; Reviewed; Region: recR; PRK00076 454166001486 RecR protein; Region: RecR; pfam02132 454166001487 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 454166001488 putative active site [active] 454166001489 putative metal-binding site [ion binding]; other site 454166001490 tetramer interface [polypeptide binding]; other site 454166001491 heat shock protein 90; Provisional; Region: PRK05218 454166001492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166001493 ATP binding site [chemical binding]; other site 454166001494 Mg2+ binding site [ion binding]; other site 454166001495 G-X-G motif; other site 454166001496 adenylate kinase; Reviewed; Region: adk; PRK00279 454166001497 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 454166001498 AMP-binding site [chemical binding]; other site 454166001499 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 454166001500 ferrochelatase; Reviewed; Region: hemH; PRK00035 454166001501 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 454166001502 C-terminal domain interface [polypeptide binding]; other site 454166001503 active site 454166001504 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 454166001505 active site 454166001506 N-terminal domain interface [polypeptide binding]; other site 454166001507 acetyl esterase; Provisional; Region: PRK10162 454166001508 inosine/guanosine kinase; Provisional; Region: PRK15074 454166001509 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166001510 putative cation:proton antiport protein; Provisional; Region: PRK10669 454166001511 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 454166001512 TrkA-N domain; Region: TrkA_N; pfam02254 454166001513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001514 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166001515 putative substrate translocation pore; other site 454166001516 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 454166001517 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 454166001518 active site 454166001519 metal binding site [ion binding]; metal-binding site 454166001520 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 454166001521 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 454166001522 putative deacylase active site [active] 454166001523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 454166001524 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 454166001525 copper exporting ATPase; Provisional; Region: copA; PRK10671 454166001526 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454166001527 metal-binding site [ion binding] 454166001528 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454166001529 metal-binding site [ion binding] 454166001530 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454166001531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166001532 motif II; other site 454166001533 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 454166001534 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 454166001535 DNA binding residues [nucleotide binding] 454166001536 dimer interface [polypeptide binding]; other site 454166001537 copper binding site [ion binding]; other site 454166001538 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 454166001539 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 454166001540 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 454166001541 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 454166001542 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 454166001543 Walker A/P-loop; other site 454166001544 ATP binding site [chemical binding]; other site 454166001545 Q-loop/lid; other site 454166001546 ABC transporter signature motif; other site 454166001547 Walker B; other site 454166001548 D-loop; other site 454166001549 H-loop/switch region; other site 454166001550 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 454166001551 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 454166001552 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 454166001553 oxidoreductase; Provisional; Region: PRK08017 454166001554 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 454166001555 NADP binding site [chemical binding]; other site 454166001556 active site 454166001557 steroid binding site; other site 454166001558 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 454166001559 active site 454166001560 catalytic triad [active] 454166001561 oxyanion hole [active] 454166001562 switch loop; other site 454166001563 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 454166001564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 454166001565 Walker A/P-loop; other site 454166001566 ATP binding site [chemical binding]; other site 454166001567 Q-loop/lid; other site 454166001568 ABC transporter signature motif; other site 454166001569 Walker B; other site 454166001570 D-loop; other site 454166001571 H-loop/switch region; other site 454166001572 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 454166001573 FtsX-like permease family; Region: FtsX; pfam02687 454166001574 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166001575 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 454166001576 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 454166001577 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 454166001578 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 454166001579 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 454166001580 Walker A/P-loop; other site 454166001581 ATP binding site [chemical binding]; other site 454166001582 Q-loop/lid; other site 454166001583 ABC transporter signature motif; other site 454166001584 Walker B; other site 454166001585 D-loop; other site 454166001586 H-loop/switch region; other site 454166001587 NIL domain; Region: NIL; pfam09383 454166001588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166001589 dimer interface [polypeptide binding]; other site 454166001590 conserved gate region; other site 454166001591 ABC-ATPase subunit interface; other site 454166001592 Predicted ATPase [General function prediction only]; Region: COG2603 454166001593 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 454166001594 active site residue [active] 454166001595 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 454166001596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166001597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166001598 dimerization interface [polypeptide binding]; other site 454166001599 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 454166001600 ureidoglycolate hydrolase; Provisional; Region: PRK03606 454166001601 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 454166001602 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454166001603 Bacterial transcriptional regulator; Region: IclR; pfam01614 454166001604 glyoxylate carboligase; Provisional; Region: PRK11269 454166001605 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454166001606 PYR/PP interface [polypeptide binding]; other site 454166001607 dimer interface [polypeptide binding]; other site 454166001608 TPP binding site [chemical binding]; other site 454166001609 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454166001610 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 454166001611 TPP-binding site [chemical binding]; other site 454166001612 hydroxypyruvate isomerase; Provisional; Region: PRK09997 454166001613 tartronate semialdehyde reductase; Provisional; Region: PRK15059 454166001614 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454166001615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166001617 putative substrate translocation pore; other site 454166001618 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 454166001619 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 454166001620 Na binding site [ion binding]; other site 454166001621 putative substrate binding site [chemical binding]; other site 454166001622 allantoinase; Provisional; Region: PRK08044 454166001623 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 454166001624 active site 454166001625 putative uracil/xanthine transporter; Provisional; Region: PRK11412 454166001626 glycerate kinase II; Provisional; Region: PRK09932 454166001627 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 454166001628 Mif2/CENP-C like; Region: Mif2; pfam11699 454166001629 Cupin domain; Region: Cupin_2; pfam07883 454166001630 allantoate amidohydrolase; Region: AllC; TIGR03176 454166001631 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 454166001632 active site 454166001633 metal binding site [ion binding]; metal-binding site 454166001634 dimer interface [polypeptide binding]; other site 454166001635 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 454166001636 membrane protein FdrA; Validated; Region: PRK06091 454166001637 CoA binding domain; Region: CoA_binding; pfam02629 454166001638 CoA-ligase; Region: Ligase_CoA; pfam00549 454166001639 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 454166001640 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 454166001641 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 454166001642 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 454166001643 putative substrate binding site [chemical binding]; other site 454166001644 nucleotide binding site [chemical binding]; other site 454166001645 nucleotide binding site [chemical binding]; other site 454166001646 homodimer interface [polypeptide binding]; other site 454166001647 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 454166001648 ATP-grasp domain; Region: ATP-grasp; pfam02222 454166001649 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 454166001650 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 454166001651 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454166001652 putative active site [active] 454166001653 putative metal binding site [ion binding]; other site 454166001654 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 454166001655 substrate binding site [chemical binding]; other site 454166001656 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 454166001657 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 454166001658 active site 454166001659 HIGH motif; other site 454166001660 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 454166001661 KMSKS motif; other site 454166001662 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 454166001663 tRNA binding surface [nucleotide binding]; other site 454166001664 anticodon binding site; other site 454166001665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 454166001666 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 454166001667 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 454166001668 ribosome-associated protein; Provisional; Region: PRK11507 454166001669 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 454166001670 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 454166001671 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 454166001672 homodimer interface [polypeptide binding]; other site 454166001673 NADP binding site [chemical binding]; other site 454166001674 substrate binding site [chemical binding]; other site 454166001675 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 454166001676 fimbrial protein FimI; Provisional; Region: PRK15200 454166001677 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 454166001678 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166001679 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166001680 outer membrane usher protein FimD; Provisional; Region: PRK15198 454166001681 PapC N-terminal domain; Region: PapC_N; pfam13954 454166001682 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166001683 PapC C-terminal domain; Region: PapC_C; pfam13953 454166001684 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 454166001685 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 454166001686 transcriptional regulator FimZ; Provisional; Region: PRK09935 454166001687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166001688 active site 454166001689 phosphorylation site [posttranslational modification] 454166001690 intermolecular recognition site; other site 454166001691 dimerization interface [polypeptide binding]; other site 454166001692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166001693 DNA binding residues [nucleotide binding] 454166001694 dimerization interface [polypeptide binding]; other site 454166001695 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 454166001696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166001697 DNA binding residues [nucleotide binding] 454166001698 dimerization interface [polypeptide binding]; other site 454166001699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 454166001700 Transposase; Region: HTH_Tnp_1; cl17663 454166001701 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 454166001702 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 454166001703 Ligand binding site; other site 454166001704 Putative Catalytic site; other site 454166001705 DXD motif; other site 454166001706 Predicted membrane protein [Function unknown]; Region: COG2246 454166001707 GtrA-like protein; Region: GtrA; pfam04138 454166001708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166001709 ATP binding site [chemical binding]; other site 454166001710 Mg2+ binding site [ion binding]; other site 454166001711 G-X-G motif; other site 454166001712 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 454166001713 Cupin; Region: Cupin_6; pfam12852 454166001714 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 454166001715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166001716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166001717 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 454166001718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166001719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454166001720 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166001721 Predicted membrane protein [Function unknown]; Region: COG3059 454166001722 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 454166001723 phenylalanine transporter; Provisional; Region: PRK10249 454166001724 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 454166001725 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166001726 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 454166001727 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 454166001728 active site 454166001729 oxyanion hole [active] 454166001730 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 454166001731 catalytic triad [active] 454166001732 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 454166001733 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 454166001734 dimer interface [polypeptide binding]; other site 454166001735 FMN binding site [chemical binding]; other site 454166001736 hypothetical protein; Provisional; Region: PRK10250 454166001737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454166001738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166001739 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 454166001740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166001741 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 454166001742 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 454166001743 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 454166001744 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 454166001745 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 454166001746 outer membrane receptor FepA; Provisional; Region: PRK13524 454166001747 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166001748 N-terminal plug; other site 454166001749 ligand-binding site [chemical binding]; other site 454166001750 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 454166001751 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 454166001752 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 454166001753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 454166001754 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 454166001755 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 454166001756 acyl-activating enzyme (AAE) consensus motif; other site 454166001757 AMP binding site [chemical binding]; other site 454166001758 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 454166001759 LPS O-antigen length regulator; Provisional; Region: PRK10381 454166001760 Chain length determinant protein; Region: Wzz; pfam02706 454166001761 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 454166001762 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454166001763 Walker A/P-loop; other site 454166001764 ATP binding site [chemical binding]; other site 454166001765 Q-loop/lid; other site 454166001766 ABC transporter signature motif; other site 454166001767 Walker B; other site 454166001768 D-loop; other site 454166001769 H-loop/switch region; other site 454166001770 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 454166001771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166001772 ABC-ATPase subunit interface; other site 454166001773 dimer interface [polypeptide binding]; other site 454166001774 putative PBP binding regions; other site 454166001775 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454166001776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166001777 ABC-ATPase subunit interface; other site 454166001778 dimer interface [polypeptide binding]; other site 454166001779 putative PBP binding regions; other site 454166001780 enterobactin exporter EntS; Provisional; Region: PRK10489 454166001781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166001782 putative substrate translocation pore; other site 454166001783 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 454166001784 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 454166001785 siderophore binding site; other site 454166001786 isochorismate synthase EntC; Provisional; Region: PRK15016 454166001787 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 454166001788 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 454166001789 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 454166001790 acyl-activating enzyme (AAE) consensus motif; other site 454166001791 active site 454166001792 AMP binding site [chemical binding]; other site 454166001793 substrate binding site [chemical binding]; other site 454166001794 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 454166001795 hydrophobic substrate binding pocket; other site 454166001796 Isochorismatase family; Region: Isochorismatase; pfam00857 454166001797 active site 454166001798 conserved cis-peptide bond; other site 454166001799 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 454166001800 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 454166001801 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 454166001802 putative NAD(P) binding site [chemical binding]; other site 454166001803 active site 454166001804 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 454166001805 CoenzymeA binding site [chemical binding]; other site 454166001806 subunit interaction site [polypeptide binding]; other site 454166001807 PHB binding site; other site 454166001808 carbon starvation protein A; Provisional; Region: PRK15015 454166001809 Carbon starvation protein CstA; Region: CstA; pfam02554 454166001810 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 454166001811 Uncharacterized small protein [Function unknown]; Region: COG2879 454166001812 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 454166001813 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 454166001814 putative active site [active] 454166001815 metal binding site [ion binding]; metal-binding site 454166001816 methionine aminotransferase; Validated; Region: PRK09082 454166001817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166001818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166001819 homodimer interface [polypeptide binding]; other site 454166001820 catalytic residue [active] 454166001821 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 454166001822 ParB-like nuclease domain; Region: ParBc; pfam02195 454166001823 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 454166001824 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 454166001825 Active Sites [active] 454166001826 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 454166001827 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 454166001828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166001829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166001830 dimerization interface [polypeptide binding]; other site 454166001831 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 454166001832 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 454166001833 dimerization domain [polypeptide binding]; other site 454166001834 dimer interface [polypeptide binding]; other site 454166001835 catalytic residues [active] 454166001836 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 454166001837 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 454166001838 dimer interface [polypeptide binding]; other site 454166001839 decamer (pentamer of dimers) interface [polypeptide binding]; other site 454166001840 catalytic triad [active] 454166001841 peroxidatic and resolving cysteines [active] 454166001842 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 454166001843 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 454166001844 catalytic residue [active] 454166001845 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 454166001846 catalytic residues [active] 454166001847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454166001848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166001849 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 454166001850 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 454166001851 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 454166001852 putative [4Fe-4S] binding site [ion binding]; other site 454166001853 putative molybdopterin cofactor binding site [chemical binding]; other site 454166001854 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 454166001855 molybdopterin cofactor binding site; other site 454166001856 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 454166001857 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 454166001858 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 454166001859 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454166001860 Ligand Binding Site [chemical binding]; other site 454166001861 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 454166001862 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454166001863 NAD binding site [chemical binding]; other site 454166001864 catalytic Zn binding site [ion binding]; other site 454166001865 structural Zn binding site [ion binding]; other site 454166001866 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 454166001867 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 454166001868 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 454166001869 B1 nucleotide binding pocket [chemical binding]; other site 454166001870 B2 nucleotide binding pocket [chemical binding]; other site 454166001871 CAS motifs; other site 454166001872 active site 454166001873 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 454166001874 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 454166001875 transmembrane helices; other site 454166001876 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 454166001877 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 454166001878 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 454166001879 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 454166001880 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 454166001881 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 454166001882 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 454166001883 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 454166001884 putative active site [active] 454166001885 (T/H)XGH motif; other site 454166001886 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 454166001887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166001888 putative active site [active] 454166001889 heme pocket [chemical binding]; other site 454166001890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166001891 ATP binding site [chemical binding]; other site 454166001892 Mg2+ binding site [ion binding]; other site 454166001893 G-X-G motif; other site 454166001894 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 454166001895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166001896 active site 454166001897 phosphorylation site [posttranslational modification] 454166001898 intermolecular recognition site; other site 454166001899 dimerization interface [polypeptide binding]; other site 454166001900 Transcriptional regulator; Region: CitT; pfam12431 454166001901 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 454166001902 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 454166001903 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 454166001904 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454166001905 DNA-binding site [nucleotide binding]; DNA binding site 454166001906 RNA-binding motif; other site 454166001907 chromosome condensation membrane protein; Provisional; Region: PRK14196 454166001908 Predicted amidohydrolase [General function prediction only]; Region: COG0388 454166001909 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 454166001910 putative active site [active] 454166001911 catalytic triad [active] 454166001912 putative dimer interface [polypeptide binding]; other site 454166001913 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 454166001914 lipoyl synthase; Provisional; Region: PRK05481 454166001915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166001916 FeS/SAM binding site; other site 454166001917 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 454166001918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166001919 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 454166001920 substrate binding pocket [chemical binding]; other site 454166001921 dimerization interface [polypeptide binding]; other site 454166001922 lipoate-protein ligase B; Provisional; Region: PRK14342 454166001923 hypothetical protein; Provisional; Region: PRK04998 454166001924 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 454166001925 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 454166001926 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 454166001927 rare lipoprotein A; Provisional; Region: PRK10672 454166001928 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 454166001929 Sporulation related domain; Region: SPOR; pfam05036 454166001930 cell wall shape-determining protein; Provisional; Region: PRK10794 454166001931 penicillin-binding protein 2; Provisional; Region: PRK10795 454166001932 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454166001933 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454166001934 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 454166001935 ribosome-associated protein; Provisional; Region: PRK11538 454166001936 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454166001937 catalytic core [active] 454166001938 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 454166001939 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166001940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166001941 homodimer interface [polypeptide binding]; other site 454166001942 catalytic residue [active] 454166001943 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 454166001944 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 454166001945 active site 454166001946 (T/H)XGH motif; other site 454166001947 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 454166001948 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 454166001949 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 454166001950 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 454166001951 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 454166001952 HIGH motif; other site 454166001953 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 454166001954 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 454166001955 active site 454166001956 KMSKS motif; other site 454166001957 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 454166001958 tRNA binding surface [nucleotide binding]; other site 454166001959 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 454166001960 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 454166001961 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 454166001962 Propionate catabolism activator; Region: PrpR_N; pfam06506 454166001963 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 454166001964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166001965 Walker A motif; other site 454166001966 ATP binding site [chemical binding]; other site 454166001967 Walker B motif; other site 454166001968 arginine finger; other site 454166001969 hypothetical protein; Provisional; Region: PRK11032 454166001970 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 454166001971 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166001972 Sel1-like repeats; Region: SEL1; smart00671 454166001973 Sel1-like repeats; Region: SEL1; smart00671 454166001974 Sel1-like repeats; Region: SEL1; smart00671 454166001975 Sel1-like repeats; Region: SEL1; smart00671 454166001976 Sel1-like repeats; Region: SEL1; smart00671 454166001977 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 454166001978 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 454166001979 HSP70 interaction site [polypeptide binding]; other site 454166001980 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 454166001981 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 454166001982 HSP70 interaction site [polypeptide binding]; other site 454166001983 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 454166001984 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 454166001985 nucleotide binding site [chemical binding]; other site 454166001986 putative NEF/HSP70 interaction site [polypeptide binding]; other site 454166001987 SBD interface [polypeptide binding]; other site 454166001988 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 454166001989 active site 454166001990 tetramer interface [polypeptide binding]; other site 454166001991 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 454166001992 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454166001993 Walker A/P-loop; other site 454166001994 ATP binding site [chemical binding]; other site 454166001995 Q-loop/lid; other site 454166001996 ABC transporter signature motif; other site 454166001997 Walker B; other site 454166001998 D-loop; other site 454166001999 H-loop/switch region; other site 454166002000 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166002001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002002 dimer interface [polypeptide binding]; other site 454166002003 conserved gate region; other site 454166002004 putative PBP binding loops; other site 454166002005 ABC-ATPase subunit interface; other site 454166002006 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166002007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002008 dimer interface [polypeptide binding]; other site 454166002009 conserved gate region; other site 454166002010 putative PBP binding loops; other site 454166002011 ABC-ATPase subunit interface; other site 454166002012 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 454166002013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166002014 substrate binding pocket [chemical binding]; other site 454166002015 membrane-bound complex binding site; other site 454166002016 hinge residues; other site 454166002017 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 454166002018 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 454166002019 putative active site [active] 454166002020 catalytic triad [active] 454166002021 putative dimer interface [polypeptide binding]; other site 454166002022 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 454166002023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454166002024 Transporter associated domain; Region: CorC_HlyC; smart01091 454166002025 metal-binding heat shock protein; Provisional; Region: PRK00016 454166002026 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 454166002027 PhoH-like protein; Region: PhoH; pfam02562 454166002028 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 454166002029 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 454166002030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166002031 FeS/SAM binding site; other site 454166002032 TRAM domain; Region: TRAM; pfam01938 454166002033 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 454166002034 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454166002035 Integrase core domain; Region: rve; pfam00665 454166002036 Integrase core domain; Region: rve_3; pfam13683 454166002037 Helix-turn-helix domain; Region: HTH_28; pfam13518 454166002038 asparagine synthetase B; Provisional; Region: asnB; PRK09431 454166002039 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 454166002040 active site 454166002041 dimer interface [polypeptide binding]; other site 454166002042 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 454166002043 Ligand Binding Site [chemical binding]; other site 454166002044 Molecular Tunnel; other site 454166002045 UMP phosphatase; Provisional; Region: PRK10444 454166002046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002047 active site 454166002048 motif I; other site 454166002049 motif II; other site 454166002050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002051 MarR family; Region: MarR; pfam01047 454166002052 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 454166002053 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166002054 nucleotide binding site [chemical binding]; other site 454166002055 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 454166002056 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 454166002057 active site 454166002058 dimer interface [polypeptide binding]; other site 454166002059 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 454166002060 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 454166002061 active site 454166002062 trimer interface [polypeptide binding]; other site 454166002063 allosteric site; other site 454166002064 active site lid [active] 454166002065 hexamer (dimer of trimers) interface [polypeptide binding]; other site 454166002066 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 454166002067 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454166002068 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454166002069 active site turn [active] 454166002070 phosphorylation site [posttranslational modification] 454166002071 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 454166002072 HPr interaction site; other site 454166002073 glycerol kinase (GK) interaction site [polypeptide binding]; other site 454166002074 active site 454166002075 phosphorylation site [posttranslational modification] 454166002076 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 454166002077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 454166002078 active site 454166002079 HIGH motif; other site 454166002080 nucleotide binding site [chemical binding]; other site 454166002081 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 454166002082 KMSKS motif; other site 454166002083 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 454166002084 outer membrane porin, OprD family; Region: OprD; pfam03573 454166002085 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 454166002086 YbfN-like lipoprotein; Region: YbfN; pfam13982 454166002087 citrate-proton symporter; Provisional; Region: PRK15075 454166002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166002089 putative substrate translocation pore; other site 454166002090 tricarballylate utilization protein B; Provisional; Region: PRK15033 454166002091 tricarballylate dehydrogenase; Validated; Region: PRK08274 454166002092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454166002093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166002094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166002095 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 454166002096 putative dimerization interface [polypeptide binding]; other site 454166002097 ferric uptake regulator; Provisional; Region: fur; PRK09462 454166002098 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 454166002099 metal binding site 2 [ion binding]; metal-binding site 454166002100 putative DNA binding helix; other site 454166002101 metal binding site 1 [ion binding]; metal-binding site 454166002102 dimer interface [polypeptide binding]; other site 454166002103 structural Zn2+ binding site [ion binding]; other site 454166002104 flavodoxin FldA; Validated; Region: PRK09267 454166002105 LexA regulated protein; Provisional; Region: PRK11675 454166002106 acyl-CoA esterase; Provisional; Region: PRK10673 454166002107 PGAP1-like protein; Region: PGAP1; pfam07819 454166002108 replication initiation regulator SeqA; Provisional; Region: PRK11187 454166002109 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 454166002110 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 454166002111 active site 454166002112 substrate binding site [chemical binding]; other site 454166002113 metal binding site [ion binding]; metal-binding site 454166002114 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 454166002115 putrescine transporter; Provisional; Region: potE; PRK10655 454166002116 ornithine decarboxylase; Provisional; Region: PRK13578 454166002117 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454166002118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454166002119 homodimer interface [polypeptide binding]; other site 454166002120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166002121 catalytic residue [active] 454166002122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454166002123 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 454166002124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166002125 active site 454166002126 phosphorylation site [posttranslational modification] 454166002127 intermolecular recognition site; other site 454166002128 dimerization interface [polypeptide binding]; other site 454166002129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166002130 DNA binding site [nucleotide binding] 454166002131 sensor protein KdpD; Provisional; Region: PRK10490 454166002132 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 454166002133 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 454166002134 Ligand Binding Site [chemical binding]; other site 454166002135 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 454166002136 GAF domain; Region: GAF_3; pfam13492 454166002137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166002138 dimer interface [polypeptide binding]; other site 454166002139 phosphorylation site [posttranslational modification] 454166002140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166002141 ATP binding site [chemical binding]; other site 454166002142 Mg2+ binding site [ion binding]; other site 454166002143 G-X-G motif; other site 454166002144 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 454166002145 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 454166002146 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454166002147 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 454166002148 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 454166002149 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 454166002150 DNA photolyase; Region: DNA_photolyase; pfam00875 454166002151 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 454166002152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166002153 putative substrate translocation pore; other site 454166002154 POT family; Region: PTR2; pfam00854 454166002155 Uncharacterized conserved protein [Function unknown]; Region: COG0327 454166002156 metal-binding protein; Provisional; Region: PRK10799 454166002157 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 454166002158 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 454166002159 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 454166002160 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 454166002161 putative active site [active] 454166002162 endonuclease VIII; Provisional; Region: PRK10445 454166002163 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 454166002164 DNA binding site [nucleotide binding] 454166002165 catalytic residue [active] 454166002166 putative catalytic residues [active] 454166002167 H2TH interface [polypeptide binding]; other site 454166002168 intercalation triad [nucleotide binding]; other site 454166002169 substrate specificity determining residue; other site 454166002170 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 454166002171 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 454166002172 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 454166002173 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 454166002174 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 454166002175 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 454166002176 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 454166002177 dimer interface [polypeptide binding]; other site 454166002178 active site 454166002179 citrylCoA binding site [chemical binding]; other site 454166002180 NADH binding [chemical binding]; other site 454166002181 cationic pore residues; other site 454166002182 oxalacetate/citrate binding site [chemical binding]; other site 454166002183 coenzyme A binding site [chemical binding]; other site 454166002184 catalytic triad [active] 454166002185 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 454166002186 Iron-sulfur protein interface; other site 454166002187 proximal quinone binding site [chemical binding]; other site 454166002188 SdhD (CybS) interface [polypeptide binding]; other site 454166002189 proximal heme binding site [chemical binding]; other site 454166002190 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 454166002191 SdhC subunit interface [polypeptide binding]; other site 454166002192 proximal heme binding site [chemical binding]; other site 454166002193 cardiolipin binding site; other site 454166002194 Iron-sulfur protein interface; other site 454166002195 proximal quinone binding site [chemical binding]; other site 454166002196 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 454166002197 L-aspartate oxidase; Provisional; Region: PRK06175 454166002198 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 454166002199 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 454166002200 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 454166002201 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 454166002202 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 454166002203 TPP-binding site [chemical binding]; other site 454166002204 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 454166002205 dimer interface [polypeptide binding]; other site 454166002206 PYR/PP interface [polypeptide binding]; other site 454166002207 TPP binding site [chemical binding]; other site 454166002208 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 454166002209 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454166002210 E3 interaction surface; other site 454166002211 lipoyl attachment site [posttranslational modification]; other site 454166002212 e3 binding domain; Region: E3_binding; pfam02817 454166002213 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 454166002214 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 454166002215 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 454166002216 CoA-ligase; Region: Ligase_CoA; pfam00549 454166002217 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 454166002218 CoA binding domain; Region: CoA_binding; smart00881 454166002219 CoA-ligase; Region: Ligase_CoA; pfam00549 454166002220 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 454166002221 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 454166002222 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 454166002223 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 454166002224 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 454166002225 hypothetical protein; Provisional; Region: PRK10588 454166002226 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 454166002227 active site 454166002228 colicin uptake protein TolQ; Provisional; Region: PRK10801 454166002229 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 454166002230 colicin uptake protein TolR; Provisional; Region: PRK11024 454166002231 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 454166002232 TolA C-terminal; Region: TolA; pfam06519 454166002233 translocation protein TolB; Provisional; Region: tolB; PRK03629 454166002234 TolB amino-terminal domain; Region: TolB_N; pfam04052 454166002235 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 454166002236 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 454166002237 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 454166002238 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 454166002239 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454166002240 ligand binding site [chemical binding]; other site 454166002241 tol-pal system protein YbgF; Provisional; Region: PRK10803 454166002242 Tetratricopeptide repeat; Region: TPR_6; pfam13174 454166002243 Tetratricopeptide repeat; Region: TPR_6; pfam13174 454166002244 quinolinate synthetase; Provisional; Region: PRK09375 454166002245 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 454166002246 zinc transporter ZitB; Provisional; Region: PRK03557 454166002247 YbgS-like protein; Region: YbgS; pfam13985 454166002248 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 454166002249 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454166002250 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 454166002251 fumarate hydratase; Provisional; Region: PRK06246 454166002252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166002253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166002254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166002255 dimerization interface [polypeptide binding]; other site 454166002256 cell density-dependent motility repressor; Provisional; Region: PRK10082 454166002257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166002258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166002259 dimerization interface [polypeptide binding]; other site 454166002260 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 454166002261 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454166002262 transmembrane helices; other site 454166002263 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 454166002264 oxaloacetate decarboxylase; Provisional; Region: PRK14040 454166002265 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 454166002266 active site 454166002267 catalytic residues [active] 454166002268 metal binding site [ion binding]; metal-binding site 454166002269 homodimer binding site [polypeptide binding]; other site 454166002270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454166002271 carboxyltransferase (CT) interaction site; other site 454166002272 biotinylation site [posttranslational modification]; other site 454166002273 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 454166002274 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 454166002275 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454166002276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166002277 dimer interface [polypeptide binding]; other site 454166002278 putative PBP binding regions; other site 454166002279 ABC-ATPase subunit interface; other site 454166002280 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 454166002281 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454166002282 Walker A/P-loop; other site 454166002283 ATP binding site [chemical binding]; other site 454166002284 Q-loop/lid; other site 454166002285 ABC transporter signature motif; other site 454166002286 Walker B; other site 454166002287 D-loop; other site 454166002288 H-loop/switch region; other site 454166002289 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454166002290 catalytic core [active] 454166002291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454166002292 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 454166002293 active site 454166002294 catalytic residues [active] 454166002295 galactokinase; Provisional; Region: PRK05101 454166002296 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 454166002297 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 454166002298 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 454166002299 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 454166002300 dimer interface [polypeptide binding]; other site 454166002301 active site 454166002302 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 454166002303 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 454166002304 NAD binding site [chemical binding]; other site 454166002305 homodimer interface [polypeptide binding]; other site 454166002306 active site 454166002307 substrate binding site [chemical binding]; other site 454166002308 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 454166002309 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 454166002310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002311 Walker A/P-loop; other site 454166002312 ATP binding site [chemical binding]; other site 454166002313 Q-loop/lid; other site 454166002314 ABC transporter signature motif; other site 454166002315 Walker B; other site 454166002316 D-loop; other site 454166002317 H-loop/switch region; other site 454166002318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002319 Walker A/P-loop; other site 454166002320 ATP binding site [chemical binding]; other site 454166002321 Q-loop/lid; other site 454166002322 ABC transporter signature motif; other site 454166002323 Walker B; other site 454166002324 D-loop; other site 454166002325 H-loop/switch region; other site 454166002326 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 454166002327 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 454166002328 molybdenum-pterin binding domain; Region: Mop; TIGR00638 454166002329 TOBE domain; Region: TOBE; pfam03459 454166002330 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 454166002331 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 454166002332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166002333 substrate binding pocket [chemical binding]; other site 454166002334 membrane-bound complex binding site; other site 454166002335 hinge residues; other site 454166002336 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 454166002337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002338 dimer interface [polypeptide binding]; other site 454166002339 conserved gate region; other site 454166002340 putative PBP binding loops; other site 454166002341 ABC-ATPase subunit interface; other site 454166002342 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 454166002343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002344 Walker A/P-loop; other site 454166002345 ATP binding site [chemical binding]; other site 454166002346 Q-loop/lid; other site 454166002347 ABC transporter signature motif; other site 454166002348 Walker B; other site 454166002349 D-loop; other site 454166002350 H-loop/switch region; other site 454166002351 molybdenum-pterin binding domain; Region: Mop; TIGR00638 454166002352 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 454166002353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002354 active site 454166002355 motif I; other site 454166002356 motif II; other site 454166002357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002358 6-phosphogluconolactonase; Provisional; Region: PRK11028 454166002359 acyl-CoA thioesterase; Provisional; Region: PRK10531 454166002360 putative pectinesterase; Region: PLN02432; cl01911 454166002361 imidazolonepropionase; Validated; Region: PRK09356 454166002362 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 454166002363 active site 454166002364 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 454166002365 putative active site [active] 454166002366 putative metal binding site [ion binding]; other site 454166002367 histidine utilization repressor; Provisional; Region: PRK14999 454166002368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166002369 DNA-binding site [nucleotide binding]; DNA binding site 454166002370 UTRA domain; Region: UTRA; pfam07702 454166002371 urocanate hydratase; Provisional; Region: PRK05414 454166002372 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 454166002373 active sites [active] 454166002374 tetramer interface [polypeptide binding]; other site 454166002375 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 454166002376 substrate binding site [chemical binding]; other site 454166002377 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 454166002378 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454166002379 inhibitor-cofactor binding pocket; inhibition site 454166002380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166002381 catalytic residue [active] 454166002382 biotin synthase; Provisional; Region: PRK15108 454166002383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166002384 FeS/SAM binding site; other site 454166002385 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 454166002386 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 454166002387 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 454166002388 substrate-cofactor binding pocket; other site 454166002389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166002390 catalytic residue [active] 454166002391 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 454166002392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166002393 S-adenosylmethionine binding site [chemical binding]; other site 454166002394 AAA domain; Region: AAA_26; pfam13500 454166002395 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 454166002396 excinuclease ABC subunit B; Provisional; Region: PRK05298 454166002397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166002398 ATP binding site [chemical binding]; other site 454166002399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166002400 nucleotide binding region [chemical binding]; other site 454166002401 ATP-binding site [chemical binding]; other site 454166002402 Ultra-violet resistance protein B; Region: UvrB; pfam12344 454166002403 UvrB/uvrC motif; Region: UVR; pfam02151 454166002404 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 454166002405 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 454166002406 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 454166002407 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 454166002408 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 454166002409 putative substrate binding pocket [chemical binding]; other site 454166002410 dimer interface [polypeptide binding]; other site 454166002411 phosphate binding site [ion binding]; other site 454166002412 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 454166002413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166002414 FeS/SAM binding site; other site 454166002415 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 454166002416 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 454166002417 MPT binding site; other site 454166002418 trimer interface [polypeptide binding]; other site 454166002419 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 454166002420 trimer interface [polypeptide binding]; other site 454166002421 dimer interface [polypeptide binding]; other site 454166002422 putative active site [active] 454166002423 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 454166002424 MoaE interaction surface [polypeptide binding]; other site 454166002425 MoeB interaction surface [polypeptide binding]; other site 454166002426 thiocarboxylated glycine; other site 454166002427 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 454166002428 MoaE homodimer interface [polypeptide binding]; other site 454166002429 MoaD interaction [polypeptide binding]; other site 454166002430 active site residues [active] 454166002431 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454166002432 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 454166002433 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454166002434 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 454166002435 Predicted integral membrane protein [Function unknown]; Region: COG0392 454166002436 cardiolipin synthase 2; Provisional; Region: PRK11263 454166002437 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 454166002438 putative active site [active] 454166002439 catalytic site [active] 454166002440 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 454166002441 putative active site [active] 454166002442 catalytic site [active] 454166002443 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 454166002444 putative catalytic site [active] 454166002445 putative metal binding site [ion binding]; other site 454166002446 putative phosphate binding site [ion binding]; other site 454166002447 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 454166002448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454166002449 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 454166002450 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454166002451 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 454166002452 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 454166002453 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454166002454 Walker A/P-loop; other site 454166002455 ATP binding site [chemical binding]; other site 454166002456 Q-loop/lid; other site 454166002457 ABC transporter signature motif; other site 454166002458 Walker B; other site 454166002459 D-loop; other site 454166002460 H-loop/switch region; other site 454166002461 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 454166002462 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454166002463 Walker A/P-loop; other site 454166002464 ATP binding site [chemical binding]; other site 454166002465 Q-loop/lid; other site 454166002466 ABC transporter signature motif; other site 454166002467 Walker B; other site 454166002468 D-loop; other site 454166002469 H-loop/switch region; other site 454166002470 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 454166002471 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 454166002472 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166002473 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 454166002474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166002475 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 454166002476 helicase 45; Provisional; Region: PTZ00424 454166002477 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454166002478 ATP binding site [chemical binding]; other site 454166002479 Mg++ binding site [ion binding]; other site 454166002480 motif III; other site 454166002481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166002482 nucleotide binding region [chemical binding]; other site 454166002483 ATP-binding site [chemical binding]; other site 454166002484 Transposase; Region: DEDD_Tnp_IS110; pfam01548 454166002485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 454166002486 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 454166002487 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 454166002488 DEAD_2; Region: DEAD_2; pfam06733 454166002489 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 454166002490 glycosyl transferase family protein; Provisional; Region: PRK08136 454166002491 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 454166002492 hypothetical protein; Provisional; Region: PRK10259 454166002493 hypothetical protein; Provisional; Region: PRK11019 454166002494 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 454166002495 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 454166002496 putative mechanosensitive channel protein; Provisional; Region: PRK11465 454166002497 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166002498 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 454166002499 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454166002500 Walker A/P-loop; other site 454166002501 ATP binding site [chemical binding]; other site 454166002502 Q-loop/lid; other site 454166002503 ABC transporter signature motif; other site 454166002504 Walker B; other site 454166002505 D-loop; other site 454166002506 H-loop/switch region; other site 454166002507 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166002508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002509 dimer interface [polypeptide binding]; other site 454166002510 conserved gate region; other site 454166002511 putative PBP binding loops; other site 454166002512 ABC-ATPase subunit interface; other site 454166002513 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 454166002514 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166002515 substrate binding pocket [chemical binding]; other site 454166002516 membrane-bound complex binding site; other site 454166002517 hinge residues; other site 454166002518 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 454166002519 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 454166002520 dimerization interface [polypeptide binding]; other site 454166002521 DPS ferroxidase diiron center [ion binding]; other site 454166002522 ion pore; other site 454166002523 threonine and homoserine efflux system; Provisional; Region: PRK10532 454166002524 EamA-like transporter family; Region: EamA; pfam00892 454166002525 outer membrane protein X; Provisional; Region: ompX; PRK09408 454166002526 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 454166002527 Sulfatase; Region: Sulfatase; pfam00884 454166002528 manganese transport regulator MntR; Provisional; Region: PRK11050 454166002529 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 454166002530 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 454166002531 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 454166002532 transmembrane helices; other site 454166002533 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 454166002534 L,D-transpeptidase; Provisional; Region: PRK10260 454166002535 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454166002536 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 454166002537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166002538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002539 Walker A/P-loop; other site 454166002540 ATP binding site [chemical binding]; other site 454166002541 ABC transporter signature motif; other site 454166002542 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166002543 Walker B; other site 454166002544 ABC transporter; Region: ABC_tran_2; pfam12848 454166002545 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166002546 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 454166002547 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 454166002548 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 454166002549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002550 active site 454166002551 motif I; other site 454166002552 motif II; other site 454166002553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002554 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 454166002555 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 454166002556 dimer interface [polypeptide binding]; other site 454166002557 active site 454166002558 glycine loop; other site 454166002559 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 454166002560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166002561 FeS/SAM binding site; other site 454166002562 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 454166002563 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 454166002564 ATP binding site [chemical binding]; other site 454166002565 substrate interface [chemical binding]; other site 454166002566 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 454166002567 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 454166002568 dimer interface [polypeptide binding]; other site 454166002569 putative functional site; other site 454166002570 putative MPT binding site; other site 454166002571 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 454166002572 catalytic nucleophile [active] 454166002573 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 454166002574 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166002575 Walker A/P-loop; other site 454166002576 ATP binding site [chemical binding]; other site 454166002577 Q-loop/lid; other site 454166002578 ABC transporter signature motif; other site 454166002579 Walker B; other site 454166002580 D-loop; other site 454166002581 H-loop/switch region; other site 454166002582 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454166002583 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166002584 Walker A/P-loop; other site 454166002585 ATP binding site [chemical binding]; other site 454166002586 Q-loop/lid; other site 454166002587 ABC transporter signature motif; other site 454166002588 Walker B; other site 454166002589 D-loop; other site 454166002590 H-loop/switch region; other site 454166002591 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 454166002592 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 454166002593 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 454166002594 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 454166002595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002596 dimer interface [polypeptide binding]; other site 454166002597 conserved gate region; other site 454166002598 putative PBP binding loops; other site 454166002599 ABC-ATPase subunit interface; other site 454166002600 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 454166002601 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454166002602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002603 dimer interface [polypeptide binding]; other site 454166002604 conserved gate region; other site 454166002605 putative PBP binding loops; other site 454166002606 ABC-ATPase subunit interface; other site 454166002607 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 454166002608 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 454166002609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166002610 FeS/SAM binding site; other site 454166002611 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 454166002612 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 454166002613 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 454166002614 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 454166002615 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 454166002616 putative C-terminal domain interface [polypeptide binding]; other site 454166002617 putative GSH binding site (G-site) [chemical binding]; other site 454166002618 putative dimer interface [polypeptide binding]; other site 454166002619 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 454166002620 putative N-terminal domain interface [polypeptide binding]; other site 454166002621 putative dimer interface [polypeptide binding]; other site 454166002622 putative substrate binding pocket (H-site) [chemical binding]; other site 454166002623 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 454166002624 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 454166002625 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 454166002626 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 454166002627 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454166002628 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166002629 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454166002630 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 454166002631 active site 454166002632 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 454166002633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166002634 putative substrate translocation pore; other site 454166002635 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 454166002636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002637 active site 454166002638 motif I; other site 454166002639 motif II; other site 454166002640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166002641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166002642 putative substrate translocation pore; other site 454166002643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166002644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 454166002645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166002646 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 454166002647 putative transporter; Provisional; Region: PRK04972 454166002648 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 454166002649 TrkA-C domain; Region: TrkA_C; pfam02080 454166002650 TrkA-C domain; Region: TrkA_C; pfam02080 454166002651 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 454166002652 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 454166002653 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 454166002654 GSH binding site [chemical binding]; other site 454166002655 catalytic residues [active] 454166002656 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 454166002657 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 454166002658 dimer interface [polypeptide binding]; other site 454166002659 FMN binding site [chemical binding]; other site 454166002660 NADPH bind site [chemical binding]; other site 454166002661 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 454166002662 RimK-like ATP-grasp domain; Region: RimK; pfam08443 454166002663 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 454166002664 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 454166002665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 454166002666 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 454166002667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002668 Walker A/P-loop; other site 454166002669 ATP binding site [chemical binding]; other site 454166002670 Q-loop/lid; other site 454166002671 ABC transporter signature motif; other site 454166002672 Walker B; other site 454166002673 D-loop; other site 454166002674 H-loop/switch region; other site 454166002675 TOBE domain; Region: TOBE_2; pfam08402 454166002676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002677 dimer interface [polypeptide binding]; other site 454166002678 conserved gate region; other site 454166002679 putative PBP binding loops; other site 454166002680 ABC-ATPase subunit interface; other site 454166002681 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 454166002682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002683 dimer interface [polypeptide binding]; other site 454166002684 conserved gate region; other site 454166002685 putative PBP binding loops; other site 454166002686 ABC-ATPase subunit interface; other site 454166002687 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 454166002688 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 454166002689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166002690 S-adenosylmethionine binding site [chemical binding]; other site 454166002691 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 454166002692 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 454166002693 Sulfatase; Region: Sulfatase; cl17466 454166002694 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 454166002695 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166002696 substrate binding pocket [chemical binding]; other site 454166002697 membrane-bound complex binding site; other site 454166002698 hinge residues; other site 454166002699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002700 dimer interface [polypeptide binding]; other site 454166002701 conserved gate region; other site 454166002702 putative PBP binding loops; other site 454166002703 ABC-ATPase subunit interface; other site 454166002704 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166002705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166002706 dimer interface [polypeptide binding]; other site 454166002707 conserved gate region; other site 454166002708 putative PBP binding loops; other site 454166002709 ABC-ATPase subunit interface; other site 454166002710 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 454166002711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166002712 substrate binding pocket [chemical binding]; other site 454166002713 membrane-bound complex binding site; other site 454166002714 hinge residues; other site 454166002715 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 454166002716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002717 Walker A/P-loop; other site 454166002718 ATP binding site [chemical binding]; other site 454166002719 Q-loop/lid; other site 454166002720 ABC transporter signature motif; other site 454166002721 Walker B; other site 454166002722 D-loop; other site 454166002723 H-loop/switch region; other site 454166002724 putative lipoprotein; Provisional; Region: PRK10533 454166002725 hypothetical protein; Provisional; Region: PRK02877 454166002726 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 454166002727 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 454166002728 amidase catalytic site [active] 454166002729 Zn binding residues [ion binding]; other site 454166002730 substrate binding site [chemical binding]; other site 454166002731 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 454166002732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 454166002733 NAD(P) binding site [chemical binding]; other site 454166002734 active site 454166002735 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 454166002736 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 454166002737 putative NAD(P) binding site [chemical binding]; other site 454166002738 putative active site [active] 454166002739 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 454166002740 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 454166002741 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 454166002742 tetramer interface [polypeptide binding]; other site 454166002743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166002744 catalytic residue [active] 454166002745 pyruvate dehydrogenase; Provisional; Region: PRK09124 454166002746 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 454166002747 PYR/PP interface [polypeptide binding]; other site 454166002748 dimer interface [polypeptide binding]; other site 454166002749 tetramer interface [polypeptide binding]; other site 454166002750 TPP binding site [chemical binding]; other site 454166002751 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454166002752 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 454166002753 TPP-binding site [chemical binding]; other site 454166002754 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 454166002755 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 454166002756 FAD binding pocket [chemical binding]; other site 454166002757 FAD binding motif [chemical binding]; other site 454166002758 phosphate binding motif [ion binding]; other site 454166002759 beta-alpha-beta structure motif; other site 454166002760 NAD binding pocket [chemical binding]; other site 454166002761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454166002762 catalytic loop [active] 454166002763 iron binding site [ion binding]; other site 454166002764 hybrid cluster protein; Provisional; Region: PRK05290 454166002765 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454166002766 ACS interaction site; other site 454166002767 CODH interaction site; other site 454166002768 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 454166002769 hybrid metal cluster; other site 454166002770 Predicted membrane protein [Function unknown]; Region: COG2431 454166002771 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 454166002772 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 454166002773 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 454166002774 putative active site [active] 454166002775 putative metal-binding site [ion binding]; other site 454166002776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 454166002777 macrolide transporter subunit MacA; Provisional; Region: PRK11578 454166002778 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166002779 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166002780 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 454166002781 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 454166002782 Walker A/P-loop; other site 454166002783 ATP binding site [chemical binding]; other site 454166002784 Q-loop/lid; other site 454166002785 ABC transporter signature motif; other site 454166002786 Walker B; other site 454166002787 D-loop; other site 454166002788 H-loop/switch region; other site 454166002789 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 454166002790 FtsX-like permease family; Region: FtsX; pfam02687 454166002791 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454166002792 DNA-binding site [nucleotide binding]; DNA binding site 454166002793 RNA-binding motif; other site 454166002794 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 454166002795 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 454166002796 Clp amino terminal domain; Region: Clp_N; pfam02861 454166002797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166002798 Walker A motif; other site 454166002799 ATP binding site [chemical binding]; other site 454166002800 Walker B motif; other site 454166002801 arginine finger; other site 454166002802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166002803 Walker A motif; other site 454166002804 ATP binding site [chemical binding]; other site 454166002805 Walker B motif; other site 454166002806 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 454166002807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454166002808 DNA binding site [nucleotide binding] 454166002809 active site 454166002810 Int/Topo IB signature motif; other site 454166002811 Isochorismatase family; Region: Isochorismatase; pfam00857 454166002812 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 454166002813 catalytic triad [active] 454166002814 dimer interface [polypeptide binding]; other site 454166002815 conserved cis-peptide bond; other site 454166002816 Pirin-related protein [General function prediction only]; Region: COG1741 454166002817 Pirin; Region: Pirin; pfam02678 454166002818 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 454166002819 LysR family transcriptional regulator; Provisional; Region: PRK14997 454166002820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166002821 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 454166002822 putative effector binding pocket; other site 454166002823 putative dimerization interface [polypeptide binding]; other site 454166002824 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 454166002825 rRNA binding site [nucleotide binding]; other site 454166002826 predicted 30S ribosome binding site; other site 454166002827 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 454166002828 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 454166002829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166002830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002831 Walker A/P-loop; other site 454166002832 ATP binding site [chemical binding]; other site 454166002833 Q-loop/lid; other site 454166002834 ABC transporter signature motif; other site 454166002835 Walker B; other site 454166002836 D-loop; other site 454166002837 H-loop/switch region; other site 454166002838 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 454166002839 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166002840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166002841 Walker A/P-loop; other site 454166002842 ATP binding site [chemical binding]; other site 454166002843 Q-loop/lid; other site 454166002844 ABC transporter signature motif; other site 454166002845 Walker B; other site 454166002846 D-loop; other site 454166002847 H-loop/switch region; other site 454166002848 thioredoxin reductase; Provisional; Region: PRK10262 454166002849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454166002850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166002851 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 454166002852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166002853 putative DNA binding site [nucleotide binding]; other site 454166002854 putative Zn2+ binding site [ion binding]; other site 454166002855 AsnC family; Region: AsnC_trans_reg; pfam01037 454166002856 DNA translocase FtsK; Provisional; Region: PRK10263 454166002857 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 454166002858 DNA translocase FtsK; Provisional; Region: PRK10263 454166002859 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 454166002860 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 454166002861 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 454166002862 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 454166002863 recombination factor protein RarA; Reviewed; Region: PRK13342 454166002864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166002865 Walker A motif; other site 454166002866 ATP binding site [chemical binding]; other site 454166002867 Walker B motif; other site 454166002868 arginine finger; other site 454166002869 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 454166002870 seryl-tRNA synthetase; Provisional; Region: PRK05431 454166002871 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 454166002872 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 454166002873 dimer interface [polypeptide binding]; other site 454166002874 active site 454166002875 motif 1; other site 454166002876 motif 2; other site 454166002877 motif 3; other site 454166002878 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 454166002879 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454166002880 putative [Fe4-S4] binding site [ion binding]; other site 454166002881 putative molybdopterin cofactor binding site [chemical binding]; other site 454166002882 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454166002883 putative molybdopterin cofactor binding site; other site 454166002884 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454166002885 4Fe-4S binding domain; Region: Fer4; pfam00037 454166002886 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 454166002887 putative MFS family transporter protein; Provisional; Region: PRK03633 454166002888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166002889 putative substrate translocation pore; other site 454166002890 inner membrane transporter YjeM; Provisional; Region: PRK15238 454166002891 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 454166002892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166002893 FeS/SAM binding site; other site 454166002894 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 454166002895 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 454166002896 Pyruvate formate lyase 1; Region: PFL1; cd01678 454166002897 coenzyme A binding site [chemical binding]; other site 454166002898 active site 454166002899 catalytic residues [active] 454166002900 glycine loop; other site 454166002901 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 454166002902 uncharacterized domain; Region: TIGR00702 454166002903 YcaO-like family; Region: YcaO; pfam02624 454166002904 Predicted membrane protein [Function unknown]; Region: COG2323 454166002905 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 454166002906 homodimer interface [polypeptide binding]; other site 454166002907 substrate-cofactor binding pocket; other site 454166002908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166002909 catalytic residue [active] 454166002910 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 454166002911 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 454166002912 hinge; other site 454166002913 active site 454166002914 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 454166002915 cytidylate kinase; Provisional; Region: cmk; PRK00023 454166002916 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 454166002917 CMP-binding site; other site 454166002918 The sites determining sugar specificity; other site 454166002919 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 454166002920 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 454166002921 RNA binding site [nucleotide binding]; other site 454166002922 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 454166002923 RNA binding site [nucleotide binding]; other site 454166002924 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 454166002925 RNA binding site [nucleotide binding]; other site 454166002926 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 454166002927 RNA binding site [nucleotide binding]; other site 454166002928 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 454166002929 RNA binding site [nucleotide binding]; other site 454166002930 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454166002931 IHF dimer interface [polypeptide binding]; other site 454166002932 IHF - DNA interface [nucleotide binding]; other site 454166002933 ComEC family competence protein; Provisional; Region: PRK11539 454166002934 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 454166002935 Competence protein; Region: Competence; pfam03772 454166002936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 454166002937 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 454166002938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166002939 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 454166002940 Walker A/P-loop; other site 454166002941 ATP binding site [chemical binding]; other site 454166002942 Q-loop/lid; other site 454166002943 ABC transporter signature motif; other site 454166002944 Walker B; other site 454166002945 D-loop; other site 454166002946 H-loop/switch region; other site 454166002947 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 454166002948 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 454166002949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 454166002950 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 454166002951 hypothetical protein; Provisional; Region: PRK11827 454166002952 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 454166002953 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 454166002954 Ligand binding site; other site 454166002955 oligomer interface; other site 454166002956 hypothetical protein; Provisional; Region: PRK10593 454166002957 Uncharacterized conserved protein [Function unknown]; Region: COG1434 454166002958 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454166002959 putative active site [active] 454166002960 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 454166002961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166002962 S-adenosylmethionine binding site [chemical binding]; other site 454166002963 condesin subunit F; Provisional; Region: PRK05260 454166002964 condesin subunit E; Provisional; Region: PRK05256 454166002965 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 454166002966 P-loop containing region of AAA domain; Region: AAA_29; cl17516 454166002967 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 454166002968 murein L,D-transpeptidase; Provisional; Region: PRK10594 454166002969 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 454166002970 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454166002971 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454166002972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 454166002973 Peptidase M15; Region: Peptidase_M15_3; cl01194 454166002974 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 454166002975 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 454166002976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166002977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166002978 homodimer interface [polypeptide binding]; other site 454166002979 catalytic residue [active] 454166002980 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166002981 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454166002982 trimer interface [polypeptide binding]; other site 454166002983 eyelet of channel; other site 454166002984 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 454166002985 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 454166002986 putative dimer interface [polypeptide binding]; other site 454166002987 putative anticodon binding site; other site 454166002988 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 454166002989 homodimer interface [polypeptide binding]; other site 454166002990 motif 1; other site 454166002991 motif 2; other site 454166002992 active site 454166002993 motif 3; other site 454166002994 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 454166002995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166002996 putative DNA binding site [nucleotide binding]; other site 454166002997 putative Zn2+ binding site [ion binding]; other site 454166002998 AsnC family; Region: AsnC_trans_reg; pfam01037 454166002999 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 454166003000 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 454166003001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166003002 catalytic residue [active] 454166003003 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 454166003004 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 454166003005 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 454166003006 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 454166003007 active site 454166003008 aminopeptidase N; Provisional; Region: pepN; PRK14015 454166003009 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 454166003010 active site 454166003011 Zn binding site [ion binding]; other site 454166003012 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 454166003013 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 454166003014 quinone interaction residues [chemical binding]; other site 454166003015 active site 454166003016 catalytic residues [active] 454166003017 FMN binding site [chemical binding]; other site 454166003018 substrate binding site [chemical binding]; other site 454166003019 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 454166003020 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 454166003021 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 454166003022 MOSC domain; Region: MOSC; pfam03473 454166003023 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 454166003024 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454166003025 catalytic loop [active] 454166003026 iron binding site [ion binding]; other site 454166003027 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 454166003028 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 454166003029 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 454166003030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166003031 S-adenosylmethionine binding site [chemical binding]; other site 454166003032 ABC transporter ATPase component; Reviewed; Region: PRK11147 454166003033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166003034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166003035 Walker A/P-loop; other site 454166003036 Walker A/P-loop; other site 454166003037 ATP binding site [chemical binding]; other site 454166003038 ATP binding site [chemical binding]; other site 454166003039 Q-loop/lid; other site 454166003040 Q-loop/lid; other site 454166003041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166003042 ABC transporter signature motif; other site 454166003043 Walker B; other site 454166003044 D-loop; other site 454166003045 ABC transporter; Region: ABC_tran_2; pfam12848 454166003046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166003047 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 454166003048 Paraquat-inducible protein A; Region: PqiA; pfam04403 454166003049 Paraquat-inducible protein A; Region: PqiA; pfam04403 454166003050 paraquat-inducible protein B; Provisional; Region: PRK10807 454166003051 mce related protein; Region: MCE; pfam02470 454166003052 mce related protein; Region: MCE; pfam02470 454166003053 mce related protein; Region: MCE; pfam02470 454166003054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 454166003055 Protein of unknown function (DUF330); Region: DUF330; pfam03886 454166003056 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 454166003057 active site 1 [active] 454166003058 dimer interface [polypeptide binding]; other site 454166003059 active site 2 [active] 454166003060 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 454166003061 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 454166003062 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 454166003063 outer membrane protein A; Reviewed; Region: PRK10808 454166003064 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 454166003065 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454166003066 ligand binding site [chemical binding]; other site 454166003067 cell division inhibitor SulA; Region: sula; TIGR00623 454166003068 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 454166003069 TfoX C-terminal domain; Region: TfoX_C; pfam04994 454166003070 TIGR01666 family membrane protein; Region: YCCS 454166003071 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 454166003072 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454166003073 Predicted membrane protein [Function unknown]; Region: COG3304 454166003074 Domain of unknown function (DUF307); Region: DUF307; pfam03733 454166003075 Domain of unknown function (DUF307); Region: DUF307; pfam03733 454166003076 DNA helicase IV; Provisional; Region: helD; PRK11054 454166003077 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 454166003078 Part of AAA domain; Region: AAA_19; pfam13245 454166003079 Family description; Region: UvrD_C_2; pfam13538 454166003080 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 454166003081 active site 454166003082 dimer interfaces [polypeptide binding]; other site 454166003083 catalytic residues [active] 454166003084 hypothetical protein; Provisional; Region: PRK03641 454166003085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 454166003086 heat shock protein HspQ; Provisional; Region: PRK14129 454166003087 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 454166003088 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 454166003089 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 454166003090 putative RNA binding site [nucleotide binding]; other site 454166003091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166003092 S-adenosylmethionine binding site [chemical binding]; other site 454166003093 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 454166003094 substrate binding site [chemical binding]; other site 454166003095 Cupin domain; Region: Cupin_2; cl17218 454166003096 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166003097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166003098 acylphosphatase; Provisional; Region: PRK14426 454166003099 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 454166003100 sulfur transfer protein TusE; Provisional; Region: PRK11508 454166003101 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454166003102 YccA-like proteins; Region: YccA_like; cd10433 454166003103 PipA protein; Region: PipA; pfam07108 454166003104 secreted effector protein PipB; Provisional; Region: PRK15197 454166003105 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454166003106 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454166003107 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 454166003108 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 454166003109 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 454166003110 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 454166003111 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 454166003112 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 454166003113 HAMP domain; Region: HAMP; pfam00672 454166003114 dimerization interface [polypeptide binding]; other site 454166003115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166003116 dimer interface [polypeptide binding]; other site 454166003117 phosphorylation site [posttranslational modification] 454166003118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166003119 ATP binding site [chemical binding]; other site 454166003120 Mg2+ binding site [ion binding]; other site 454166003121 G-X-G motif; other site 454166003122 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 454166003123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166003124 active site 454166003125 phosphorylation site [posttranslational modification] 454166003126 intermolecular recognition site; other site 454166003127 dimerization interface [polypeptide binding]; other site 454166003128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166003129 DNA binding site [nucleotide binding] 454166003130 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 454166003131 active site 454166003132 homotetramer interface [polypeptide binding]; other site 454166003133 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 454166003134 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 454166003135 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 454166003136 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 454166003137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 454166003138 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 454166003139 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 454166003140 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 454166003141 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 454166003142 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 454166003143 NAD binding site [chemical binding]; other site 454166003144 catalytic residues [active] 454166003145 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 454166003146 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 454166003147 putative active site [active] 454166003148 putative metal binding site [ion binding]; other site 454166003149 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 454166003150 putative substrate binding pocket [chemical binding]; other site 454166003151 trimer interface [polypeptide binding]; other site 454166003152 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 454166003153 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 454166003154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166003155 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 454166003156 putative substrate translocation pore; other site 454166003157 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 454166003158 Cupin domain; Region: Cupin_2; pfam07883 454166003159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166003160 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 454166003161 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 454166003162 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 454166003163 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 454166003164 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 454166003165 HSP70 interaction site [polypeptide binding]; other site 454166003166 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 454166003167 substrate binding site [polypeptide binding]; other site 454166003168 dimer interface [polypeptide binding]; other site 454166003169 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 454166003170 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 454166003171 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 454166003172 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 454166003173 DsbD alpha interface [polypeptide binding]; other site 454166003174 catalytic residues [active] 454166003175 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 454166003176 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 454166003177 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 454166003178 catalytic residues [active] 454166003179 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 454166003180 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 454166003181 catalytic residues [active] 454166003182 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 454166003183 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 454166003184 catalytic core [active] 454166003185 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 454166003186 hypothetical protein; Provisional; Region: PRK10174 454166003187 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 454166003188 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 454166003189 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 454166003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166003191 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 454166003192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 454166003193 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 454166003194 Predicted transcriptional regulator [Transcription]; Region: COG3905 454166003195 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 454166003196 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 454166003197 Glutamate binding site [chemical binding]; other site 454166003198 NAD binding site [chemical binding]; other site 454166003199 catalytic residues [active] 454166003200 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 454166003201 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 454166003202 Na binding site [ion binding]; other site 454166003203 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 454166003204 hypothetical protein; Provisional; Region: PRK10536 454166003205 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 454166003206 Integrase core domain; Region: rve; pfam00665 454166003207 Integrase core domain; Region: rve_3; pfam13683 454166003208 Helix-turn-helix domain; Region: HTH_28; pfam13518 454166003209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 454166003210 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 454166003211 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 454166003212 ImpA domain protein; Region: DUF3702; pfam12486 454166003213 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 454166003214 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 454166003215 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 454166003216 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 454166003217 ImpA domain protein; Region: DUF3702; pfam12486 454166003218 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 454166003219 AAA domain; Region: AAA_17; pfam13207 454166003220 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 454166003221 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 454166003222 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 454166003223 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 454166003224 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 454166003225 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 454166003226 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 454166003227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166003228 Walker A motif; other site 454166003229 ATP binding site [chemical binding]; other site 454166003230 Walker B motif; other site 454166003231 arginine finger; other site 454166003232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166003233 Walker A motif; other site 454166003234 ATP binding site [chemical binding]; other site 454166003235 Walker B motif; other site 454166003236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 454166003237 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 454166003238 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 454166003239 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 454166003240 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 454166003241 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 454166003242 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 454166003243 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 454166003244 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 454166003245 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 454166003246 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 454166003247 Protein of unknown function (DUF877); Region: DUF877; pfam05943 454166003248 Protein of unknown function (DUF770); Region: DUF770; pfam05591 454166003249 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 454166003250 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 454166003251 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 454166003252 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 454166003253 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 454166003254 PAAR motif; Region: PAAR_motif; cl15808 454166003255 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 454166003256 RHS Repeat; Region: RHS_repeat; pfam05593 454166003257 RHS Repeat; Region: RHS_repeat; pfam05593 454166003258 RHS Repeat; Region: RHS_repeat; pfam05593 454166003259 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 454166003260 RHS Repeat; Region: RHS_repeat; pfam05593 454166003261 RHS Repeat; Region: RHS_repeat; cl11982 454166003262 RHS Repeat; Region: RHS_repeat; pfam05593 454166003263 RHS Repeat; Region: RHS_repeat; pfam05593 454166003264 RHS protein; Region: RHS; pfam03527 454166003265 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 454166003266 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166003267 Sel1 repeat; Region: Sel1; pfam08238 454166003268 Sel1-like repeats; Region: SEL1; smart00671 454166003269 Sel1-like repeats; Region: SEL1; smart00671 454166003270 Sel1-like repeats; Region: SEL1; smart00671 454166003271 putative transposase OrfB; Reviewed; Region: PHA02517 454166003272 HTH-like domain; Region: HTH_21; pfam13276 454166003273 Integrase core domain; Region: rve; pfam00665 454166003274 Integrase core domain; Region: rve_2; pfam13333 454166003275 dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965 454166003276 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166003277 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454166003278 trimer interface [polypeptide binding]; other site 454166003279 eyelet of channel; other site 454166003280 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 454166003281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454166003282 Zn2+ binding site [ion binding]; other site 454166003283 Mg2+ binding site [ion binding]; other site 454166003284 DNA cytosine methylase; Provisional; Region: PRK10458 454166003285 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 454166003286 cofactor binding site; other site 454166003287 DNA binding site [nucleotide binding] 454166003288 substrate interaction site [chemical binding]; other site 454166003289 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 454166003290 additional DNA contacts [nucleotide binding]; other site 454166003291 mismatch recognition site; other site 454166003292 active site 454166003293 zinc binding site [ion binding]; other site 454166003294 DNA intercalation site [nucleotide binding]; other site 454166003295 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 454166003296 EamA-like transporter family; Region: EamA; pfam00892 454166003297 EamA-like transporter family; Region: EamA; pfam00892 454166003298 hypothetical protein; Provisional; Region: PRK10062 454166003299 Uncharacterized small protein [Function unknown]; Region: COG5475 454166003300 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 454166003301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166003302 metal binding site [ion binding]; metal-binding site 454166003303 active site 454166003304 I-site; other site 454166003305 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 454166003306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166003307 active site 454166003308 motif I; other site 454166003309 motif II; other site 454166003310 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 454166003311 hypothetical protein; Provisional; Region: PRK10708 454166003312 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 454166003313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166003314 DNA binding residues [nucleotide binding] 454166003315 dimerization interface [polypeptide binding]; other site 454166003316 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 454166003317 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 454166003318 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 454166003319 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 454166003320 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 454166003321 flagellar motor switch protein; Validated; Region: fliN; PRK05698 454166003322 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 454166003323 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 454166003324 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 454166003325 flagellar hook-length control protein; Provisional; Region: PRK10118 454166003326 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 454166003327 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 454166003328 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 454166003329 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 454166003330 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 454166003331 Walker A motif/ATP binding site; other site 454166003332 Walker B motif; other site 454166003333 flagellar assembly protein H; Validated; Region: fliH; PRK05687 454166003334 Flagellar assembly protein FliH; Region: FliH; pfam02108 454166003335 flagellar motor switch protein FliG; Region: fliG; TIGR00207 454166003336 FliG C-terminal domain; Region: FliG_C; pfam01706 454166003337 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 454166003338 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 454166003339 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 454166003340 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 454166003341 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 454166003342 CPxP motif; other site 454166003343 putative inner membrane protein; Provisional; Region: PRK11099 454166003344 Sulphur transport; Region: Sulf_transp; pfam04143 454166003345 lipoprotein; Provisional; Region: PRK10397 454166003346 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 454166003347 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 454166003348 active site 454166003349 Na/Ca binding site [ion binding]; other site 454166003350 catalytic site [active] 454166003351 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 454166003352 flagellar protein FliS; Validated; Region: fliS; PRK05685 454166003353 flagellar capping protein; Reviewed; Region: fliD; PRK08032 454166003354 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 454166003355 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 454166003356 flagellin; Validated; Region: PRK08026 454166003357 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 454166003358 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 454166003359 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 454166003360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454166003361 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 454166003362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454166003363 DNA binding residues [nucleotide binding] 454166003364 cystine transporter subunit; Provisional; Region: PRK11260 454166003365 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166003366 substrate binding pocket [chemical binding]; other site 454166003367 membrane-bound complex binding site; other site 454166003368 hinge residues; other site 454166003369 D-cysteine desulfhydrase; Validated; Region: PRK03910 454166003370 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 454166003371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166003372 catalytic residue [active] 454166003373 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166003374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166003375 dimer interface [polypeptide binding]; other site 454166003376 conserved gate region; other site 454166003377 putative PBP binding loops; other site 454166003378 ABC-ATPase subunit interface; other site 454166003379 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 454166003380 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454166003381 Walker A/P-loop; other site 454166003382 ATP binding site [chemical binding]; other site 454166003383 Q-loop/lid; other site 454166003384 ABC transporter signature motif; other site 454166003385 Walker B; other site 454166003386 D-loop; other site 454166003387 H-loop/switch region; other site 454166003388 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454166003389 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 454166003390 Autoinducer binding domain; Region: Autoind_bind; pfam03472 454166003391 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166003392 DNA binding residues [nucleotide binding] 454166003393 dimerization interface [polypeptide binding]; other site 454166003394 hypothetical protein; Provisional; Region: PRK10613 454166003395 response regulator; Provisional; Region: PRK09483 454166003396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166003397 active site 454166003398 phosphorylation site [posttranslational modification] 454166003399 intermolecular recognition site; other site 454166003400 dimerization interface [polypeptide binding]; other site 454166003401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166003402 DNA binding residues [nucleotide binding] 454166003403 dimerization interface [polypeptide binding]; other site 454166003404 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 454166003405 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 454166003406 GIY-YIG motif/motif A; other site 454166003407 active site 454166003408 catalytic site [active] 454166003409 putative DNA binding site [nucleotide binding]; other site 454166003410 metal binding site [ion binding]; metal-binding site 454166003411 UvrB/uvrC motif; Region: UVR; pfam02151 454166003412 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 454166003413 Helix-hairpin-helix motif; Region: HHH; pfam00633 454166003414 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 454166003415 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 454166003416 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 454166003417 NlpC/P60 family; Region: NLPC_P60; cl17555 454166003418 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 454166003419 hypothetical protein; Provisional; Region: PRK10396 454166003420 yecA family protein; Region: ygfB_yecA; TIGR02292 454166003421 SEC-C motif; Region: SEC-C; pfam02810 454166003422 tyrosine transporter TyrP; Provisional; Region: PRK15132 454166003423 aromatic amino acid transport protein; Region: araaP; TIGR00837 454166003424 probable metal-binding protein; Region: matur_matur; TIGR03853 454166003425 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 454166003426 Ferritin-like domain; Region: Ferritin; pfam00210 454166003427 ferroxidase diiron center [ion binding]; other site 454166003428 YecR-like lipoprotein; Region: YecR; pfam13992 454166003429 hypothetical protein; Provisional; Region: PRK09273 454166003430 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 454166003431 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 454166003432 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 454166003433 Ferritin-like domain; Region: Ferritin; pfam00210 454166003434 ferroxidase diiron center [ion binding]; other site 454166003435 DJ-1 family protein; Region: not_thiJ; TIGR01383 454166003436 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 454166003437 conserved cys residue [active] 454166003438 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 454166003439 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 454166003440 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 454166003441 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 454166003442 active site 454166003443 homotetramer interface [polypeptide binding]; other site 454166003444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454166003445 Ligand Binding Site [chemical binding]; other site 454166003446 transcriptional activator FlhD; Provisional; Region: PRK02909 454166003447 transcriptional activator FlhC; Provisional; Region: PRK12722 454166003448 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 454166003449 flagellar motor protein MotA; Validated; Region: PRK09110 454166003450 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 454166003451 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 454166003452 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454166003453 ligand binding site [chemical binding]; other site 454166003454 chemotaxis protein CheA; Provisional; Region: PRK10547 454166003455 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454166003456 putative binding surface; other site 454166003457 active site 454166003458 CheY binding; Region: CheY-binding; pfam09078 454166003459 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 454166003460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166003461 ATP binding site [chemical binding]; other site 454166003462 Mg2+ binding site [ion binding]; other site 454166003463 G-X-G motif; other site 454166003464 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 454166003465 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 454166003466 putative CheA interaction surface; other site 454166003467 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 454166003468 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 454166003469 dimer interface [polypeptide binding]; other site 454166003470 ligand binding site [chemical binding]; other site 454166003471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166003472 dimerization interface [polypeptide binding]; other site 454166003473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166003474 dimer interface [polypeptide binding]; other site 454166003475 putative CheW interface [polypeptide binding]; other site 454166003476 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 454166003477 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 454166003478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166003479 S-adenosylmethionine binding site [chemical binding]; other site 454166003480 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 454166003481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166003482 active site 454166003483 phosphorylation site [posttranslational modification] 454166003484 intermolecular recognition site; other site 454166003485 dimerization interface [polypeptide binding]; other site 454166003486 CheB methylesterase; Region: CheB_methylest; pfam01339 454166003487 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 454166003488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166003489 active site 454166003490 phosphorylation site [posttranslational modification] 454166003491 intermolecular recognition site; other site 454166003492 dimerization interface [polypeptide binding]; other site 454166003493 chemotaxis regulator CheZ; Provisional; Region: PRK11166 454166003494 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 454166003495 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 454166003496 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 454166003497 FHIPEP family; Region: FHIPEP; pfam00771 454166003498 Flagellar protein FlhE; Region: FlhE; pfam06366 454166003499 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 454166003500 penicillin-binding protein 2; Provisional; Region: PRK10795 454166003501 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454166003502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454166003503 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 454166003504 arginyl-tRNA synthetase; Region: argS; TIGR00456 454166003505 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 454166003506 active site 454166003507 HIGH motif; other site 454166003508 KMSK motif region; other site 454166003509 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 454166003510 tRNA binding surface [nucleotide binding]; other site 454166003511 anticodon binding site; other site 454166003512 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 454166003513 putative metal binding site [ion binding]; other site 454166003514 copper homeostasis protein CutC; Provisional; Region: PRK11572 454166003515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166003516 S-adenosylmethionine binding site [chemical binding]; other site 454166003517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166003518 S-adenosylmethionine binding site [chemical binding]; other site 454166003519 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 454166003520 hypothetical protein; Provisional; Region: PRK10302 454166003521 Isochorismatase family; Region: Isochorismatase; pfam00857 454166003522 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 454166003523 catalytic triad [active] 454166003524 conserved cis-peptide bond; other site 454166003525 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 454166003526 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 454166003527 dimer interface [polypeptide binding]; other site 454166003528 anticodon binding site; other site 454166003529 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 454166003530 homodimer interface [polypeptide binding]; other site 454166003531 motif 1; other site 454166003532 active site 454166003533 motif 2; other site 454166003534 GAD domain; Region: GAD; pfam02938 454166003535 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 454166003536 active site 454166003537 motif 3; other site 454166003538 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 454166003539 nudix motif; other site 454166003540 hypothetical protein; Validated; Region: PRK00110 454166003541 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 454166003542 active site 454166003543 putative DNA-binding cleft [nucleotide binding]; other site 454166003544 dimer interface [polypeptide binding]; other site 454166003545 hypothetical protein; Provisional; Region: PRK11470 454166003546 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 454166003547 RuvA N terminal domain; Region: RuvA_N; pfam01330 454166003548 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 454166003549 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 454166003550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166003551 Walker A motif; other site 454166003552 ATP binding site [chemical binding]; other site 454166003553 Walker B motif; other site 454166003554 arginine finger; other site 454166003555 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 454166003556 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 454166003557 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166003558 ABC-ATPase subunit interface; other site 454166003559 dimer interface [polypeptide binding]; other site 454166003560 putative PBP binding regions; other site 454166003561 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 454166003562 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 454166003563 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 454166003564 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 454166003565 metal binding site [ion binding]; metal-binding site 454166003566 putative peptidase; Provisional; Region: PRK11649 454166003567 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 454166003568 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166003569 Peptidase family M23; Region: Peptidase_M23; pfam01551 454166003570 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 454166003571 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 454166003572 putative acyl-acceptor binding pocket; other site 454166003573 pyruvate kinase; Provisional; Region: PRK05826 454166003574 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 454166003575 domain interfaces; other site 454166003576 active site 454166003577 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 454166003578 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 454166003579 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 454166003580 putative active site [active] 454166003581 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 454166003582 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 454166003583 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 454166003584 phosphogluconate dehydratase; Validated; Region: PRK09054 454166003585 6-phosphogluconate dehydratase; Region: edd; TIGR01196 454166003586 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 454166003587 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 454166003588 active site 454166003589 intersubunit interface [polypeptide binding]; other site 454166003590 catalytic residue [active] 454166003591 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 454166003592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 454166003593 ATP-grasp domain; Region: ATP-grasp; pfam02222 454166003594 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 454166003595 hypothetical protein; Provisional; Region: PRK13680 454166003596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 454166003597 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 454166003598 putative metal binding site [ion binding]; other site 454166003599 protease 2; Provisional; Region: PRK10115 454166003600 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 454166003601 exodeoxyribonuclease X; Provisional; Region: PRK07983 454166003602 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 454166003603 active site 454166003604 catalytic site [active] 454166003605 substrate binding site [chemical binding]; other site 454166003606 Predicted amidohydrolase [General function prediction only]; Region: COG0388 454166003607 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 454166003608 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 454166003609 hypothetical protein; Provisional; Region: PRK10301 454166003610 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 454166003611 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 454166003612 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454166003613 DNA binding site [nucleotide binding] 454166003614 active site 454166003615 Int/Topo IB signature motif; other site 454166003616 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 454166003617 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 454166003618 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 454166003619 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 454166003620 MULE transposase domain; Region: MULE; pfam10551 454166003621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 454166003622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166003623 Coenzyme A binding pocket [chemical binding]; other site 454166003624 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 454166003625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166003626 non-specific DNA binding site [nucleotide binding]; other site 454166003627 salt bridge; other site 454166003628 sequence-specific DNA binding site [nucleotide binding]; other site 454166003629 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 454166003630 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 454166003631 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 454166003632 type III secretion protein SopE2; Provisional; Region: PRK15280 454166003633 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 454166003634 SopE GEF domain; Region: SopE_GEF; pfam07487 454166003635 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 454166003636 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454166003637 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 454166003638 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 454166003639 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 454166003640 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 454166003641 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 454166003642 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 454166003643 mce related protein; Region: MCE; pfam02470 454166003644 mce related protein; Region: MCE; pfam02470 454166003645 mce related protein; Region: MCE; pfam02470 454166003646 mce related protein; Region: MCE; pfam02470 454166003647 mce related protein; Region: MCE; pfam02470 454166003648 mce related protein; Region: MCE; pfam02470 454166003649 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 454166003650 Paraquat-inducible protein A; Region: PqiA; pfam04403 454166003651 Paraquat-inducible protein A; Region: PqiA; pfam04403 454166003652 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 454166003653 GAF domain; Region: GAF_2; pfam13185 454166003654 ProP expression regulator; Provisional; Region: PRK04950 454166003655 ProQ/FINO family; Region: ProQ; pfam04352 454166003656 carboxy-terminal protease; Provisional; Region: PRK11186 454166003657 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 454166003658 protein binding site [polypeptide binding]; other site 454166003659 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 454166003660 Catalytic dyad [active] 454166003661 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 454166003662 heat shock protein HtpX; Provisional; Region: PRK05457 454166003663 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 454166003664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166003665 dimerization interface [polypeptide binding]; other site 454166003666 putative Zn2+ binding site [ion binding]; other site 454166003667 putative DNA binding site [nucleotide binding]; other site 454166003668 Bacterial transcriptional regulator; Region: IclR; pfam01614 454166003669 YobH-like protein; Region: YobH; pfam13996 454166003670 PhoPQ regulatory protein; Provisional; Region: PRK10299 454166003671 YebO-like protein; Region: YebO; pfam13974 454166003672 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454166003673 DNA-binding site [nucleotide binding]; DNA binding site 454166003674 RNA-binding motif; other site 454166003675 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 454166003676 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 454166003677 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 454166003678 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 454166003679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166003680 S-adenosylmethionine binding site [chemical binding]; other site 454166003681 hypothetical protein; Provisional; Region: PRK11469 454166003682 Domain of unknown function DUF; Region: DUF204; pfam02659 454166003683 Domain of unknown function DUF; Region: DUF204; pfam02659 454166003684 yybP-ykoY leader 454166003685 hypothetical protein; Provisional; Region: PRK02913 454166003686 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 454166003687 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 454166003688 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 454166003689 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454166003690 active pocket/dimerization site; other site 454166003691 active site 454166003692 phosphorylation site [posttranslational modification] 454166003693 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 454166003694 active site 454166003695 phosphorylation site [posttranslational modification] 454166003696 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 454166003697 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 454166003698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454166003699 Transporter associated domain; Region: CorC_HlyC; smart01091 454166003700 phage resistance protein; Provisional; Region: PRK10551 454166003701 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454166003702 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166003703 L-serine deaminase; Provisional; Region: PRK15023 454166003704 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454166003705 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454166003706 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 454166003707 putative active site [active] 454166003708 putative CoA binding site [chemical binding]; other site 454166003709 nudix motif; other site 454166003710 metal binding site [ion binding]; metal-binding site 454166003711 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 454166003712 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 454166003713 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 454166003714 hypothetical protein; Provisional; Region: PRK05114 454166003715 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 454166003716 homotrimer interaction site [polypeptide binding]; other site 454166003717 putative active site [active] 454166003718 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 454166003719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 454166003720 DEAD_2; Region: DEAD_2; pfam06733 454166003721 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 454166003722 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 454166003723 Glycoprotease family; Region: Peptidase_M22; pfam00814 454166003724 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 454166003725 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 454166003726 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 454166003727 acyl-activating enzyme (AAE) consensus motif; other site 454166003728 putative AMP binding site [chemical binding]; other site 454166003729 putative active site [active] 454166003730 putative CoA binding site [chemical binding]; other site 454166003731 ribonuclease D; Provisional; Region: PRK10829 454166003732 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 454166003733 catalytic site [active] 454166003734 putative active site [active] 454166003735 putative substrate binding site [chemical binding]; other site 454166003736 HRDC domain; Region: HRDC; cl02578 454166003737 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 454166003738 cell division inhibitor MinD; Provisional; Region: PRK10818 454166003739 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 454166003740 Switch I; other site 454166003741 Switch II; other site 454166003742 septum formation inhibitor; Reviewed; Region: minC; PRK03511 454166003743 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 454166003744 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 454166003745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 454166003746 hypothetical protein; Provisional; Region: PRK10691 454166003747 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 454166003748 hypothetical protein; Provisional; Region: PRK05170 454166003749 GnsA/GnsB family; Region: GnsAB; pfam08178 454166003750 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 454166003751 disulfide bond formation protein B; Provisional; Region: PRK01749 454166003752 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 454166003753 transmembrane helices; other site 454166003754 fatty acid metabolism regulator; Provisional; Region: PRK04984 454166003755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166003756 DNA-binding site [nucleotide binding]; DNA binding site 454166003757 FadR C-terminal domain; Region: FadR_C; pfam07840 454166003758 SpoVR family protein; Provisional; Region: PRK11767 454166003759 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 454166003760 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 454166003761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454166003762 alanine racemase; Reviewed; Region: dadX; PRK03646 454166003763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 454166003764 active site 454166003765 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454166003766 substrate binding site [chemical binding]; other site 454166003767 catalytic residues [active] 454166003768 dimer interface [polypeptide binding]; other site 454166003769 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 454166003770 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 454166003771 TrkA-C domain; Region: TrkA_C; pfam02080 454166003772 Transporter associated domain; Region: CorC_HlyC; smart01091 454166003773 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 454166003774 dimer interface [polypeptide binding]; other site 454166003775 catalytic triad [active] 454166003776 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 454166003777 Flagellar regulator YcgR; Region: YcgR; pfam07317 454166003778 PilZ domain; Region: PilZ; pfam07238 454166003779 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 454166003780 trehalase; Provisional; Region: treA; PRK13271 454166003781 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 454166003782 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 454166003783 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 454166003784 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 454166003785 NAD(P) binding site [chemical binding]; other site 454166003786 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 454166003787 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 454166003788 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 454166003789 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 454166003790 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454166003791 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454166003792 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 454166003793 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 454166003794 putative substrate-binding site; other site 454166003795 nickel binding site [ion binding]; other site 454166003796 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 454166003797 hydrogenase 1 large subunit; Provisional; Region: PRK10170 454166003798 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 454166003799 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 454166003800 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 454166003801 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 454166003802 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 454166003803 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 454166003804 GTP-binding protein YchF; Reviewed; Region: PRK09601 454166003805 YchF GTPase; Region: YchF; cd01900 454166003806 G1 box; other site 454166003807 GTP/Mg2+ binding site [chemical binding]; other site 454166003808 Switch I region; other site 454166003809 G2 box; other site 454166003810 Switch II region; other site 454166003811 G3 box; other site 454166003812 G4 box; other site 454166003813 G5 box; other site 454166003814 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 454166003815 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 454166003816 putative active site [active] 454166003817 catalytic residue [active] 454166003818 hypothetical protein; Provisional; Region: PRK10692 454166003819 putative transporter; Provisional; Region: PRK11660 454166003820 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 454166003821 Sulfate transporter family; Region: Sulfate_transp; pfam00916 454166003822 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 454166003823 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 454166003824 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 454166003825 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166003826 active site 454166003827 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 454166003828 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 454166003829 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 454166003830 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 454166003831 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 454166003832 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 454166003833 tRNA; other site 454166003834 putative tRNA binding site [nucleotide binding]; other site 454166003835 putative NADP binding site [chemical binding]; other site 454166003836 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 454166003837 peptide chain release factor 1; Validated; Region: prfA; PRK00591 454166003838 This domain is found in peptide chain release factors; Region: PCRF; smart00937 454166003839 RF-1 domain; Region: RF-1; pfam00472 454166003840 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 454166003841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166003842 hypothetical protein; Provisional; Region: PRK10278 454166003843 hypothetical protein; Provisional; Region: PRK10941 454166003844 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 454166003845 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 454166003846 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454166003847 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 454166003848 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 454166003849 cation transport regulator; Reviewed; Region: chaB; PRK09582 454166003850 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 454166003851 putative invasin; Provisional; Region: PRK10177 454166003852 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 454166003853 transcriptional regulator NarL; Provisional; Region: PRK10651 454166003854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166003855 active site 454166003856 phosphorylation site [posttranslational modification] 454166003857 intermolecular recognition site; other site 454166003858 dimerization interface [polypeptide binding]; other site 454166003859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166003860 DNA binding residues [nucleotide binding] 454166003861 dimerization interface [polypeptide binding]; other site 454166003862 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 454166003863 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 454166003864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166003865 dimerization interface [polypeptide binding]; other site 454166003866 Histidine kinase; Region: HisKA_3; pfam07730 454166003867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166003868 ATP binding site [chemical binding]; other site 454166003869 Mg2+ binding site [ion binding]; other site 454166003870 G-X-G motif; other site 454166003871 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 454166003872 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 454166003873 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 454166003874 [4Fe-4S] binding site [ion binding]; other site 454166003875 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454166003876 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454166003877 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454166003878 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 454166003879 molybdopterin cofactor binding site; other site 454166003880 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 454166003881 4Fe-4S binding domain; Region: Fer4; cl02805 454166003882 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 454166003883 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 454166003884 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166003885 Sel1-like repeats; Region: SEL1; smart00671 454166003886 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166003887 Sel1-like repeats; Region: SEL1; smart00671 454166003888 Sel1-like repeats; Region: SEL1; smart00671 454166003889 Sel1-like repeats; Region: SEL1; smart00671 454166003890 Sel1-like repeats; Region: SEL1; smart00671 454166003891 Sel1-like repeats; Region: SEL1; smart00671 454166003892 Sel1-like repeats; Region: SEL1; smart00671 454166003893 Sel1-like repeats; Region: SEL1; smart00671 454166003894 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 454166003895 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 454166003896 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 454166003897 putative active site [active] 454166003898 putative substrate binding site [chemical binding]; other site 454166003899 putative cosubstrate binding site; other site 454166003900 catalytic site [active] 454166003901 SEC-C motif; Region: SEC-C; pfam02810 454166003902 hypothetical protein; Provisional; Region: PRK04233 454166003903 hypothetical protein; Provisional; Region: PRK10279 454166003904 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 454166003905 active site 454166003906 nucleophile elbow; other site 454166003907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166003908 active site 454166003909 response regulator of RpoS; Provisional; Region: PRK10693 454166003910 phosphorylation site [posttranslational modification] 454166003911 intermolecular recognition site; other site 454166003912 dimerization interface [polypeptide binding]; other site 454166003913 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 454166003914 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 454166003915 active site 454166003916 tetramer interface; other site 454166003917 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 454166003918 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 454166003919 thymidine kinase; Provisional; Region: PRK04296 454166003920 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 454166003921 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 454166003922 putative catalytic cysteine [active] 454166003923 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 454166003924 putative active site [active] 454166003925 metal binding site [ion binding]; metal-binding site 454166003926 hypothetical protein; Provisional; Region: PRK11111 454166003927 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 454166003928 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 454166003929 peptide binding site [polypeptide binding]; other site 454166003930 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 454166003931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166003932 dimer interface [polypeptide binding]; other site 454166003933 conserved gate region; other site 454166003934 putative PBP binding loops; other site 454166003935 ABC-ATPase subunit interface; other site 454166003936 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 454166003937 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454166003938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166003939 dimer interface [polypeptide binding]; other site 454166003940 conserved gate region; other site 454166003941 ABC-ATPase subunit interface; other site 454166003942 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 454166003943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166003944 Walker A/P-loop; other site 454166003945 ATP binding site [chemical binding]; other site 454166003946 Q-loop/lid; other site 454166003947 ABC transporter signature motif; other site 454166003948 Walker B; other site 454166003949 D-loop; other site 454166003950 H-loop/switch region; other site 454166003951 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454166003952 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 454166003953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166003954 Walker A/P-loop; other site 454166003955 ATP binding site [chemical binding]; other site 454166003956 Q-loop/lid; other site 454166003957 ABC transporter signature motif; other site 454166003958 Walker B; other site 454166003959 D-loop; other site 454166003960 H-loop/switch region; other site 454166003961 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 454166003962 Ion transport protein; Region: Ion_trans; pfam00520 454166003963 Ion channel; Region: Ion_trans_2; pfam07885 454166003964 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 454166003965 Double zinc ribbon; Region: DZR; pfam12773 454166003966 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 454166003967 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 454166003968 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 454166003969 putative active site [active] 454166003970 catalytic site [active] 454166003971 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 454166003972 putative active site [active] 454166003973 catalytic site [active] 454166003974 YciI-like protein; Reviewed; Region: PRK11370 454166003975 transport protein TonB; Provisional; Region: PRK10819 454166003976 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 454166003977 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 454166003978 intracellular septation protein A; Reviewed; Region: PRK00259 454166003979 hypothetical protein; Provisional; Region: PRK02868 454166003980 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 454166003981 outer membrane protein W; Provisional; Region: PRK10959 454166003982 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 454166003983 dimanganese center [ion binding]; other site 454166003984 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 454166003985 dinuclear metal binding motif [ion binding]; other site 454166003986 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 454166003987 dimerization interface [polypeptide binding]; other site 454166003988 metal binding site [ion binding]; metal-binding site 454166003989 General stress protein [General function prediction only]; Region: GsiB; COG3729 454166003990 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 454166003991 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 454166003992 substrate binding site [chemical binding]; other site 454166003993 active site 454166003994 catalytic residues [active] 454166003995 heterodimer interface [polypeptide binding]; other site 454166003996 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 454166003997 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 454166003998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166003999 catalytic residue [active] 454166004000 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 454166004001 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 454166004002 active site 454166004003 ribulose/triose binding site [chemical binding]; other site 454166004004 phosphate binding site [ion binding]; other site 454166004005 substrate (anthranilate) binding pocket [chemical binding]; other site 454166004006 product (indole) binding pocket [chemical binding]; other site 454166004007 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 454166004008 active site 454166004009 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 454166004010 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 454166004011 glutamine binding [chemical binding]; other site 454166004012 catalytic triad [active] 454166004013 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 454166004014 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 454166004015 anthranilate synthase component I; Provisional; Region: PRK13564 454166004016 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 454166004017 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 454166004018 Tryptophan operon leader 454166004019 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 454166004020 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 454166004021 active site 454166004022 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 454166004023 hypothetical protein; Provisional; Region: PRK11630 454166004024 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 454166004025 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166004026 RNA binding surface [nucleotide binding]; other site 454166004027 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 454166004028 probable active site [active] 454166004029 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 454166004030 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 454166004031 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 454166004032 homodimer interface [polypeptide binding]; other site 454166004033 Walker A motif; other site 454166004034 ATP binding site [chemical binding]; other site 454166004035 hydroxycobalamin binding site [chemical binding]; other site 454166004036 Walker B motif; other site 454166004037 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 454166004038 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 454166004039 NADP binding site [chemical binding]; other site 454166004040 homodimer interface [polypeptide binding]; other site 454166004041 active site 454166004042 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 454166004043 putative inner membrane peptidase; Provisional; Region: PRK11778 454166004044 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 454166004045 tandem repeat interface [polypeptide binding]; other site 454166004046 oligomer interface [polypeptide binding]; other site 454166004047 active site residues [active] 454166004048 hypothetical protein; Provisional; Region: PRK11037 454166004049 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 454166004050 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 454166004051 active site 454166004052 interdomain interaction site; other site 454166004053 putative metal-binding site [ion binding]; other site 454166004054 nucleotide binding site [chemical binding]; other site 454166004055 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 454166004056 domain I; other site 454166004057 DNA binding groove [nucleotide binding] 454166004058 phosphate binding site [ion binding]; other site 454166004059 domain II; other site 454166004060 domain III; other site 454166004061 nucleotide binding site [chemical binding]; other site 454166004062 catalytic site [active] 454166004063 domain IV; other site 454166004064 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454166004065 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454166004066 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 454166004067 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 454166004068 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 454166004069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166004070 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 454166004071 substrate binding site [chemical binding]; other site 454166004072 putative dimerization interface [polypeptide binding]; other site 454166004073 aconitate hydratase; Validated; Region: PRK09277 454166004074 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 454166004075 substrate binding site [chemical binding]; other site 454166004076 ligand binding site [chemical binding]; other site 454166004077 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 454166004078 substrate binding site [chemical binding]; other site 454166004079 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 454166004080 dimerization interface [polypeptide binding]; other site 454166004081 active site 454166004082 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454166004083 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 454166004084 active site 454166004085 Predicted membrane protein [Function unknown]; Region: COG3771 454166004086 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 454166004087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166004088 binding surface 454166004089 TPR motif; other site 454166004090 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 454166004091 active site 454166004092 dimer interface [polypeptide binding]; other site 454166004093 translation initiation factor Sui1; Validated; Region: PRK06824 454166004094 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 454166004095 putative rRNA binding site [nucleotide binding]; other site 454166004096 lipoprotein; Provisional; Region: PRK10540 454166004097 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166004098 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454166004099 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166004100 hypothetical protein; Provisional; Region: PRK13658 454166004101 RNase II stability modulator; Provisional; Region: PRK10060 454166004102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166004103 putative active site [active] 454166004104 heme pocket [chemical binding]; other site 454166004105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166004106 metal binding site [ion binding]; metal-binding site 454166004107 active site 454166004108 I-site; other site 454166004109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166004110 exoribonuclease II; Provisional; Region: PRK05054 454166004111 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 454166004112 RNB domain; Region: RNB; pfam00773 454166004113 S1 RNA binding domain; Region: S1; pfam00575 454166004114 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 454166004115 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 454166004116 NAD binding site [chemical binding]; other site 454166004117 homotetramer interface [polypeptide binding]; other site 454166004118 homodimer interface [polypeptide binding]; other site 454166004119 substrate binding site [chemical binding]; other site 454166004120 active site 454166004121 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 454166004122 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 454166004123 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 454166004124 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166004125 Walker A/P-loop; other site 454166004126 ATP binding site [chemical binding]; other site 454166004127 Q-loop/lid; other site 454166004128 ABC transporter signature motif; other site 454166004129 Walker B; other site 454166004130 D-loop; other site 454166004131 H-loop/switch region; other site 454166004132 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 454166004133 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166004134 Walker A/P-loop; other site 454166004135 ATP binding site [chemical binding]; other site 454166004136 Q-loop/lid; other site 454166004137 ABC transporter signature motif; other site 454166004138 Walker B; other site 454166004139 D-loop; other site 454166004140 H-loop/switch region; other site 454166004141 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 454166004142 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 454166004143 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454166004144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166004145 dimer interface [polypeptide binding]; other site 454166004146 conserved gate region; other site 454166004147 putative PBP binding loops; other site 454166004148 ABC-ATPase subunit interface; other site 454166004149 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 454166004150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166004151 dimer interface [polypeptide binding]; other site 454166004152 conserved gate region; other site 454166004153 putative PBP binding loops; other site 454166004154 ABC-ATPase subunit interface; other site 454166004155 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 454166004156 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 454166004157 peptide binding site [polypeptide binding]; other site 454166004158 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 454166004159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166004160 Walker A motif; other site 454166004161 ATP binding site [chemical binding]; other site 454166004162 Walker B motif; other site 454166004163 arginine finger; other site 454166004164 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 454166004165 phage shock protein PspA; Provisional; Region: PRK10698 454166004166 phage shock protein B; Provisional; Region: pspB; PRK09458 454166004167 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 454166004168 phage shock protein C; Region: phageshock_pspC; TIGR02978 454166004169 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 454166004170 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 454166004171 active site residue [active] 454166004172 Predicted ATPase [General function prediction only]; Region: COG3106 454166004173 hypothetical protein; Provisional; Region: PRK05415 454166004174 TIGR01620 family protein; Region: hyp_HI0043 454166004175 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 454166004176 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 454166004177 putative aromatic amino acid binding site; other site 454166004178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166004179 Walker A motif; other site 454166004180 ATP binding site [chemical binding]; other site 454166004181 Walker B motif; other site 454166004182 arginine finger; other site 454166004183 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 454166004184 dimer interface [polypeptide binding]; other site 454166004185 catalytic triad [active] 454166004186 peroxidatic and resolving cysteines [active] 454166004187 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 454166004188 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 454166004189 active site 454166004190 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 454166004191 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 454166004192 putative active site [active] 454166004193 Zn binding site [ion binding]; other site 454166004194 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 454166004195 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 454166004196 peptide binding site [polypeptide binding]; other site 454166004197 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 454166004198 NmrA-like family; Region: NmrA; pfam05368 454166004199 NAD(P) binding site [chemical binding]; other site 454166004200 active site lysine 454166004201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166004202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166004203 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 454166004204 putative effector binding pocket; other site 454166004205 putative dimerization interface [polypeptide binding]; other site 454166004206 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166004207 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166004208 active site 454166004209 catalytic tetrad [active] 454166004210 oxidoreductase; Provisional; Region: PRK12742 454166004211 classical (c) SDRs; Region: SDR_c; cd05233 454166004212 NAD(P) binding site [chemical binding]; other site 454166004213 active site 454166004214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454166004215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166004216 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454166004217 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 454166004218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166004219 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 454166004220 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 454166004221 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 454166004222 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 454166004223 B3/4 domain; Region: B3_4; pfam03483 454166004224 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 454166004225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166004226 non-specific DNA binding site [nucleotide binding]; other site 454166004227 salt bridge; other site 454166004228 sequence-specific DNA binding site [nucleotide binding]; other site 454166004229 Cupin domain; Region: Cupin_2; pfam07883 454166004230 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 454166004231 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166004232 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 454166004233 universal stress protein UspE; Provisional; Region: PRK11175 454166004234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454166004235 Ligand Binding Site [chemical binding]; other site 454166004236 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454166004237 Ligand Binding Site [chemical binding]; other site 454166004238 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 454166004239 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 454166004240 ligand binding site [chemical binding]; other site 454166004241 flexible hinge region; other site 454166004242 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 454166004243 putative switch regulator; other site 454166004244 non-specific DNA interactions [nucleotide binding]; other site 454166004245 DNA binding site [nucleotide binding] 454166004246 sequence specific DNA binding site [nucleotide binding]; other site 454166004247 putative cAMP binding site [chemical binding]; other site 454166004248 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 454166004249 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 454166004250 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 454166004251 DNA binding site [nucleotide binding] 454166004252 active site 454166004253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 454166004254 Smr domain; Region: Smr; pfam01713 454166004255 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 454166004256 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166004257 dimer interface [polypeptide binding]; other site 454166004258 putative CheW interface [polypeptide binding]; other site 454166004259 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 454166004260 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 454166004261 Cl binding site [ion binding]; other site 454166004262 oligomer interface [polypeptide binding]; other site 454166004263 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 454166004264 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454166004265 ATP binding site [chemical binding]; other site 454166004266 Mg++ binding site [ion binding]; other site 454166004267 motif III; other site 454166004268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166004269 nucleotide binding region [chemical binding]; other site 454166004270 ATP-binding site [chemical binding]; other site 454166004271 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 454166004272 putative RNA binding site [nucleotide binding]; other site 454166004273 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 454166004274 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 454166004275 Ligand Binding Site [chemical binding]; other site 454166004276 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 454166004277 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454166004278 Ligand Binding Site [chemical binding]; other site 454166004279 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 454166004280 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 454166004281 dimer interface [polypeptide binding]; other site 454166004282 PYR/PP interface [polypeptide binding]; other site 454166004283 TPP binding site [chemical binding]; other site 454166004284 substrate binding site [chemical binding]; other site 454166004285 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 454166004286 Domain of unknown function; Region: EKR; smart00890 454166004287 4Fe-4S binding domain; Region: Fer4_6; pfam12837 454166004288 4Fe-4S binding domain; Region: Fer4; pfam00037 454166004289 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 454166004290 TPP-binding site [chemical binding]; other site 454166004291 dimer interface [polypeptide binding]; other site 454166004292 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 454166004293 Domain of unknown function (DUF333); Region: DUF333; pfam03891 454166004294 heat-inducible protein; Provisional; Region: PRK10449 454166004295 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 454166004296 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 454166004297 putative ligand binding site [chemical binding]; other site 454166004298 putative NAD binding site [chemical binding]; other site 454166004299 catalytic site [active] 454166004300 hypothetical protein; Provisional; Region: PRK10695 454166004301 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 454166004302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 454166004303 Uncharacterized conserved protein [Function unknown]; Region: COG3791 454166004304 azoreductase; Reviewed; Region: PRK00170 454166004305 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 454166004306 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 454166004307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166004308 ATP binding site [chemical binding]; other site 454166004309 putative Mg++ binding site [ion binding]; other site 454166004310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166004311 nucleotide binding region [chemical binding]; other site 454166004312 ATP-binding site [chemical binding]; other site 454166004313 Helicase associated domain (HA2); Region: HA2; pfam04408 454166004314 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 454166004315 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 454166004316 Uncharacterized conserved protein [Function unknown]; Region: COG1434 454166004317 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454166004318 putative active site [active] 454166004319 cytochrome b561; Provisional; Region: PRK11513 454166004320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166004321 S-adenosylmethionine binding site [chemical binding]; other site 454166004322 Predicted membrane protein [Function unknown]; Region: COG5305 454166004323 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166004324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166004325 dimer interface [polypeptide binding]; other site 454166004326 conserved gate region; other site 454166004327 putative PBP binding loops; other site 454166004328 ABC-ATPase subunit interface; other site 454166004329 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 454166004330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166004331 Walker A/P-loop; other site 454166004332 ATP binding site [chemical binding]; other site 454166004333 Q-loop/lid; other site 454166004334 ABC transporter signature motif; other site 454166004335 Walker B; other site 454166004336 D-loop; other site 454166004337 H-loop/switch region; other site 454166004338 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166004339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166004340 dimer interface [polypeptide binding]; other site 454166004341 conserved gate region; other site 454166004342 putative PBP binding loops; other site 454166004343 ABC-ATPase subunit interface; other site 454166004344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166004345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 454166004346 substrate binding pocket [chemical binding]; other site 454166004347 membrane-bound complex binding site; other site 454166004348 hinge residues; other site 454166004349 Predicted membrane protein [Function unknown]; Region: COG3326 454166004350 Sif protein; Region: Sif; cl11505 454166004351 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 454166004352 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 454166004353 active site 454166004354 catalytic triad [active] 454166004355 oxyanion hole [active] 454166004356 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 454166004357 putative metal binding site [ion binding]; other site 454166004358 putative homodimer interface [polypeptide binding]; other site 454166004359 putative homotetramer interface [polypeptide binding]; other site 454166004360 putative homodimer-homodimer interface [polypeptide binding]; other site 454166004361 putative allosteric switch controlling residues; other site 454166004362 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 454166004363 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 454166004364 substrate binding site [chemical binding]; other site 454166004365 catalytic Zn binding site [ion binding]; other site 454166004366 NAD binding site [chemical binding]; other site 454166004367 structural Zn binding site [ion binding]; other site 454166004368 dimer interface [polypeptide binding]; other site 454166004369 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 454166004370 dimer interface [polypeptide binding]; other site 454166004371 ligand binding site [chemical binding]; other site 454166004372 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 454166004373 HAMP domain; Region: HAMP; pfam00672 454166004374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166004375 dimer interface [polypeptide binding]; other site 454166004376 putative CheW interface [polypeptide binding]; other site 454166004377 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 454166004378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166004379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166004380 dimerization interface [polypeptide binding]; other site 454166004381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 454166004382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 454166004383 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 454166004384 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 454166004385 substrate binding pocket [chemical binding]; other site 454166004386 catalytic triad [active] 454166004387 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 454166004388 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 454166004389 Uncharacterized conserved protein [Function unknown]; Region: COG2353 454166004390 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454166004391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166004392 DNA-binding site [nucleotide binding]; DNA binding site 454166004393 FCD domain; Region: FCD; pfam07729 454166004394 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 454166004395 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 454166004396 putative NAD(P) binding site [chemical binding]; other site 454166004397 catalytic Zn binding site [ion binding]; other site 454166004398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004399 D-galactonate transporter; Region: 2A0114; TIGR00893 454166004400 putative substrate translocation pore; other site 454166004401 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 454166004402 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 454166004403 NADP binding site [chemical binding]; other site 454166004404 homodimer interface [polypeptide binding]; other site 454166004405 active site 454166004406 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 454166004407 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 454166004408 metal binding site [ion binding]; metal-binding site 454166004409 substrate binding pocket [chemical binding]; other site 454166004410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166004411 Coenzyme A binding pocket [chemical binding]; other site 454166004412 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166004413 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454166004414 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166004415 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 454166004416 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454166004417 substrate binding site [chemical binding]; other site 454166004418 hexamer interface [polypeptide binding]; other site 454166004419 metal binding site [ion binding]; metal-binding site 454166004420 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166004421 active site 454166004422 phosphorylation site [posttranslational modification] 454166004423 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 454166004424 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454166004425 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 454166004426 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 454166004427 active site 454166004428 P-loop; other site 454166004429 phosphorylation site [posttranslational modification] 454166004430 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 454166004431 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 454166004432 oligomer interface [polypeptide binding]; other site 454166004433 active site 454166004434 metal binding site [ion binding]; metal-binding site 454166004435 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 454166004436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166004437 Coenzyme A binding pocket [chemical binding]; other site 454166004438 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 454166004439 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 454166004440 putative trimer interface [polypeptide binding]; other site 454166004441 putative CoA binding site [chemical binding]; other site 454166004442 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 454166004443 putative trimer interface [polypeptide binding]; other site 454166004444 putative CoA binding site [chemical binding]; other site 454166004445 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 454166004446 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 454166004447 gating phenylalanine in ion channel; other site 454166004448 tellurite resistance protein TehB; Provisional; Region: PRK11207 454166004449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166004450 S-adenosylmethionine binding site [chemical binding]; other site 454166004451 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 454166004452 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 454166004453 benzoate transporter; Region: benE; TIGR00843 454166004454 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 454166004455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166004456 non-specific DNA binding site [nucleotide binding]; other site 454166004457 salt bridge; other site 454166004458 sequence-specific DNA binding site [nucleotide binding]; other site 454166004459 Cupin domain; Region: Cupin_2; pfam07883 454166004460 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 454166004461 Peptidase family U32; Region: Peptidase_U32; pfam01136 454166004462 Collagenase; Region: DUF3656; pfam12392 454166004463 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 454166004464 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 454166004465 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 454166004466 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 454166004467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166004468 DNA-binding site [nucleotide binding]; DNA binding site 454166004469 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166004470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166004471 homodimer interface [polypeptide binding]; other site 454166004472 catalytic residue [active] 454166004473 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 454166004474 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 454166004475 tetrameric interface [polypeptide binding]; other site 454166004476 NAD binding site [chemical binding]; other site 454166004477 catalytic residues [active] 454166004478 substrate binding site [chemical binding]; other site 454166004479 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 454166004480 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 454166004481 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 454166004482 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 454166004483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 454166004484 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 454166004485 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 454166004486 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 454166004487 Prostaglandin dehydrogenases; Region: PGDH; cd05288 454166004488 NAD(P) binding site [chemical binding]; other site 454166004489 substrate binding site [chemical binding]; other site 454166004490 dimer interface [polypeptide binding]; other site 454166004491 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 454166004492 DNA-binding site [nucleotide binding]; DNA binding site 454166004493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 454166004494 FCD domain; Region: FCD; pfam07729 454166004495 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 454166004496 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166004497 N-terminal plug; other site 454166004498 ligand-binding site [chemical binding]; other site 454166004499 Uncharacterized conserved protein [Function unknown]; Region: COG3391 454166004500 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 454166004501 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454166004502 L-asparagine permease; Provisional; Region: PRK15049 454166004503 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 454166004504 hypothetical protein; Provisional; Region: PRK10281 454166004505 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 454166004506 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 454166004507 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 454166004508 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 454166004509 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 454166004510 [4Fe-4S] binding site [ion binding]; other site 454166004511 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454166004512 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454166004513 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454166004514 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 454166004515 molybdopterin cofactor binding site; other site 454166004516 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 454166004517 TetR family transcriptional regulator; Provisional; Region: PRK14996 454166004518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166004519 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 454166004520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004521 putative substrate translocation pore; other site 454166004522 Uncharacterized conserved protein [Function unknown]; Region: COG3791 454166004523 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166004524 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454166004525 eyelet of channel; other site 454166004526 trimer interface [polypeptide binding]; other site 454166004527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454166004528 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 454166004529 aromatic amino acid exporter; Provisional; Region: PRK11689 454166004530 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 454166004531 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 454166004532 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 454166004533 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 454166004534 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 454166004535 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 454166004536 NAD binding site [chemical binding]; other site 454166004537 substrate binding site [chemical binding]; other site 454166004538 catalytic Zn binding site [ion binding]; other site 454166004539 tetramer interface [polypeptide binding]; other site 454166004540 structural Zn binding site [ion binding]; other site 454166004541 malate dehydrogenase; Provisional; Region: PRK13529 454166004542 Malic enzyme, N-terminal domain; Region: malic; pfam00390 454166004543 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 454166004544 NAD(P) binding site [chemical binding]; other site 454166004545 biofilm-dependent modulation protein; Provisional; Region: PRK11436 454166004546 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 454166004547 acid-resistance protein; Provisional; Region: hdeB; PRK11566 454166004548 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 454166004549 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 454166004550 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 454166004551 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 454166004552 catalytic site [active] 454166004553 active site 454166004554 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 454166004555 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 454166004556 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 454166004557 active site 454166004558 catalytic site [active] 454166004559 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 454166004560 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 454166004561 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 454166004562 active site 454166004563 catalytic site [active] 454166004564 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 454166004565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166004566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166004567 homodimer interface [polypeptide binding]; other site 454166004568 catalytic residue [active] 454166004569 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 454166004570 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454166004571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166004572 DNA binding site [nucleotide binding] 454166004573 domain linker motif; other site 454166004574 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454166004575 dimerization interface (closed form) [polypeptide binding]; other site 454166004576 ligand binding site [chemical binding]; other site 454166004577 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 454166004578 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 454166004579 FMN binding site [chemical binding]; other site 454166004580 substrate binding site [chemical binding]; other site 454166004581 putative catalytic residue [active] 454166004582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166004583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166004584 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 454166004585 putative effector binding pocket; other site 454166004586 putative dimerization interface [polypeptide binding]; other site 454166004587 Domain of unknown function DUF29; Region: DUF29; pfam01724 454166004588 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 454166004589 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 454166004590 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 454166004591 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 454166004592 homotrimer interaction site [polypeptide binding]; other site 454166004593 putative active site [active] 454166004594 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 454166004595 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 454166004596 Transcriptional regulators [Transcription]; Region: MarR; COG1846 454166004597 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166004598 putative DNA binding site [nucleotide binding]; other site 454166004599 putative Zn2+ binding site [ion binding]; other site 454166004600 hypothetical protein; Provisional; Region: PRK06184 454166004601 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454166004602 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454166004603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166004605 putative substrate translocation pore; other site 454166004606 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 454166004607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 454166004608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004609 D-galactonate transporter; Region: 2A0114; TIGR00893 454166004610 putative substrate translocation pore; other site 454166004611 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454166004612 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 454166004613 putative NAD(P) binding site [chemical binding]; other site 454166004614 catalytic Zn binding site [ion binding]; other site 454166004615 structural Zn binding site [ion binding]; other site 454166004616 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454166004617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166004618 DNA-binding site [nucleotide binding]; DNA binding site 454166004619 FCD domain; Region: FCD; pfam07729 454166004620 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 454166004621 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 454166004622 active site 454166004623 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 454166004624 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 454166004625 hydrogenase 1 large subunit; Provisional; Region: PRK10170 454166004626 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 454166004627 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 454166004628 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 454166004629 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 454166004630 putative substrate-binding site; other site 454166004631 nickel binding site [ion binding]; other site 454166004632 HupF/HypC family; Region: HupF_HypC; cl00394 454166004633 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 454166004634 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454166004635 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 454166004636 Rubredoxin [Energy production and conversion]; Region: COG1773 454166004637 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 454166004638 iron binding site [ion binding]; other site 454166004639 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 454166004640 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 454166004641 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 454166004642 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166004643 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454166004644 trimer interface [polypeptide binding]; other site 454166004645 eyelet of channel; other site 454166004646 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 454166004647 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 454166004648 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 454166004649 glutaminase; Provisional; Region: PRK00971 454166004650 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 454166004651 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 454166004652 NAD(P) binding site [chemical binding]; other site 454166004653 catalytic residues [active] 454166004654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166004655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166004656 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 454166004657 putative dimerization interface [polypeptide binding]; other site 454166004658 putative arabinose transporter; Provisional; Region: PRK03545 454166004659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004660 putative substrate translocation pore; other site 454166004661 inner membrane protein; Provisional; Region: PRK10995 454166004662 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 454166004663 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 454166004664 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 454166004665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166004666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166004667 MarB protein; Region: MarB; pfam13999 454166004668 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 454166004669 EamA-like transporter family; Region: EamA; pfam00892 454166004670 putative transporter; Provisional; Region: PRK10054 454166004671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004672 putative substrate translocation pore; other site 454166004673 hypothetical protein; Provisional; Region: PRK10053 454166004674 hypothetical protein; Validated; Region: PRK03657 454166004675 General stress protein [General function prediction only]; Region: GsiB; COG3729 454166004676 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 454166004677 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 454166004678 active site 454166004679 Zn binding site [ion binding]; other site 454166004680 malonic semialdehyde reductase; Provisional; Region: PRK10538 454166004681 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 454166004682 putative NAD(P) binding site [chemical binding]; other site 454166004683 homodimer interface [polypeptide binding]; other site 454166004684 homotetramer interface [polypeptide binding]; other site 454166004685 active site 454166004686 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454166004687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166004688 DNA-binding site [nucleotide binding]; DNA binding site 454166004689 FCD domain; Region: FCD; pfam07729 454166004690 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 454166004691 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 454166004692 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454166004693 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454166004694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004695 metabolite-proton symporter; Region: 2A0106; TIGR00883 454166004696 putative substrate translocation pore; other site 454166004697 putative oxidoreductase; Provisional; Region: PRK10083 454166004698 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 454166004699 putative NAD(P) binding site [chemical binding]; other site 454166004700 catalytic Zn binding site [ion binding]; other site 454166004701 structural Zn binding site [ion binding]; other site 454166004702 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 454166004703 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 454166004704 putative active site pocket [active] 454166004705 putative metal binding site [ion binding]; other site 454166004706 hypothetical protein; Provisional; Region: PRK02237 454166004707 hypothetical protein; Provisional; Region: PRK13659 454166004708 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 454166004709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166004710 Coenzyme A binding pocket [chemical binding]; other site 454166004711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 454166004712 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 454166004713 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 454166004714 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454166004715 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454166004716 putative [Fe4-S4] binding site [ion binding]; other site 454166004717 putative molybdopterin cofactor binding site [chemical binding]; other site 454166004718 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454166004719 putative molybdopterin cofactor binding site; other site 454166004720 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454166004721 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454166004722 putative [Fe4-S4] binding site [ion binding]; other site 454166004723 putative molybdopterin cofactor binding site [chemical binding]; other site 454166004724 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454166004725 putative molybdopterin cofactor binding site; other site 454166004726 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454166004727 4Fe-4S binding domain; Region: Fer4; pfam00037 454166004728 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 454166004729 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 454166004730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166004731 dimer interface [polypeptide binding]; other site 454166004732 conserved gate region; other site 454166004733 putative PBP binding loops; other site 454166004734 ABC-ATPase subunit interface; other site 454166004735 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 454166004736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166004737 dimer interface [polypeptide binding]; other site 454166004738 conserved gate region; other site 454166004739 ABC-ATPase subunit interface; other site 454166004740 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 454166004741 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 454166004742 Walker A/P-loop; other site 454166004743 ATP binding site [chemical binding]; other site 454166004744 Q-loop/lid; other site 454166004745 ABC transporter signature motif; other site 454166004746 Walker B; other site 454166004747 D-loop; other site 454166004748 H-loop/switch region; other site 454166004749 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 454166004750 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 454166004751 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 454166004752 Cl- selectivity filter; other site 454166004753 Cl- binding residues [ion binding]; other site 454166004754 pore gating glutamate residue; other site 454166004755 dimer interface [polypeptide binding]; other site 454166004756 putative dithiobiotin synthetase; Provisional; Region: PRK12374 454166004757 AAA domain; Region: AAA_26; pfam13500 454166004758 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 454166004759 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 454166004760 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166004761 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 454166004762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166004763 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 454166004764 dimerization interface [polypeptide binding]; other site 454166004765 substrate binding pocket [chemical binding]; other site 454166004766 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454166004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004768 putative substrate translocation pore; other site 454166004769 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 454166004770 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 454166004771 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 454166004772 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 454166004773 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454166004774 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 454166004775 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 454166004776 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 454166004777 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 454166004778 ligand binding site [chemical binding]; other site 454166004779 homodimer interface [polypeptide binding]; other site 454166004780 NAD(P) binding site [chemical binding]; other site 454166004781 trimer interface B [polypeptide binding]; other site 454166004782 trimer interface A [polypeptide binding]; other site 454166004783 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 454166004784 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166004785 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166004786 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166004787 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 454166004788 Spore germination protein; Region: Spore_permease; cl17796 454166004789 GlpM protein; Region: GlpM; pfam06942 454166004790 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 454166004791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166004792 active site 454166004793 phosphorylation site [posttranslational modification] 454166004794 intermolecular recognition site; other site 454166004795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166004796 DNA binding site [nucleotide binding] 454166004797 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166004798 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454166004799 trimer interface [polypeptide binding]; other site 454166004800 eyelet of channel; other site 454166004801 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 454166004802 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 454166004803 active site 454166004804 sensor protein RstB; Provisional; Region: PRK10604 454166004805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166004806 dimerization interface [polypeptide binding]; other site 454166004807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166004808 dimer interface [polypeptide binding]; other site 454166004809 phosphorylation site [posttranslational modification] 454166004810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166004811 ATP binding site [chemical binding]; other site 454166004812 Mg2+ binding site [ion binding]; other site 454166004813 G-X-G motif; other site 454166004814 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 454166004815 fumarate hydratase; Reviewed; Region: fumC; PRK00485 454166004816 Class II fumarases; Region: Fumarase_classII; cd01362 454166004817 active site 454166004818 tetramer interface [polypeptide binding]; other site 454166004819 fumarate hydratase; Provisional; Region: PRK15389 454166004820 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 454166004821 Fumarase C-terminus; Region: Fumerase_C; pfam05683 454166004822 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 454166004823 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 454166004824 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 454166004825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 454166004826 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 454166004827 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 454166004828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 454166004829 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 454166004830 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 454166004831 active site 454166004832 purine riboside binding site [chemical binding]; other site 454166004833 putative oxidoreductase; Provisional; Region: PRK11579 454166004834 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454166004835 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454166004836 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 454166004837 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 454166004838 electron transport complex protein RsxA; Provisional; Region: PRK05151 454166004839 electron transport complex protein RnfB; Provisional; Region: PRK05113 454166004840 Putative Fe-S cluster; Region: FeS; cl17515 454166004841 4Fe-4S binding domain; Region: Fer4; pfam00037 454166004842 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 454166004843 SLBB domain; Region: SLBB; pfam10531 454166004844 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454166004845 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 454166004846 electron transport complex protein RnfG; Validated; Region: PRK01908 454166004847 electron transport complex RsxE subunit; Provisional; Region: PRK12405 454166004848 endonuclease III; Provisional; Region: PRK10702 454166004849 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 454166004850 minor groove reading motif; other site 454166004851 helix-hairpin-helix signature motif; other site 454166004852 substrate binding pocket [chemical binding]; other site 454166004853 active site 454166004854 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 454166004855 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 454166004856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004857 putative substrate translocation pore; other site 454166004858 POT family; Region: PTR2; pfam00854 454166004859 glutathionine S-transferase; Provisional; Region: PRK10542 454166004860 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 454166004861 C-terminal domain interface [polypeptide binding]; other site 454166004862 GSH binding site (G-site) [chemical binding]; other site 454166004863 dimer interface [polypeptide binding]; other site 454166004864 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 454166004865 dimer interface [polypeptide binding]; other site 454166004866 N-terminal domain interface [polypeptide binding]; other site 454166004867 substrate binding pocket (H-site) [chemical binding]; other site 454166004868 pyridoxamine kinase; Validated; Region: PRK05756 454166004869 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 454166004870 dimer interface [polypeptide binding]; other site 454166004871 pyridoxal binding site [chemical binding]; other site 454166004872 ATP binding site [chemical binding]; other site 454166004873 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 454166004874 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 454166004875 active site 454166004876 HIGH motif; other site 454166004877 dimer interface [polypeptide binding]; other site 454166004878 KMSKS motif; other site 454166004879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166004880 RNA binding surface [nucleotide binding]; other site 454166004881 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 454166004882 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 454166004883 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 454166004884 lysozyme inhibitor; Provisional; Region: PRK11372 454166004885 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 454166004886 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 454166004887 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 454166004888 transcriptional regulator SlyA; Provisional; Region: PRK03573 454166004889 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 454166004890 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 454166004891 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 454166004892 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166004893 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166004894 Fusaric acid resistance protein family; Region: FUSC; pfam04632 454166004895 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454166004896 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 454166004897 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 454166004898 E-class dimer interface [polypeptide binding]; other site 454166004899 P-class dimer interface [polypeptide binding]; other site 454166004900 active site 454166004901 Cu2+ binding site [ion binding]; other site 454166004902 Zn2+ binding site [ion binding]; other site 454166004903 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166004904 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166004905 active site 454166004906 catalytic tetrad [active] 454166004907 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 454166004908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454166004909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166004910 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 454166004911 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 454166004912 FMN binding site [chemical binding]; other site 454166004913 active site 454166004914 substrate binding site [chemical binding]; other site 454166004915 catalytic residue [active] 454166004916 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 454166004917 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 454166004918 dimer interface [polypeptide binding]; other site 454166004919 active site 454166004920 metal binding site [ion binding]; metal-binding site 454166004921 glutathione binding site [chemical binding]; other site 454166004922 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 454166004923 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 454166004924 dimer interface [polypeptide binding]; other site 454166004925 catalytic site [active] 454166004926 putative active site [active] 454166004927 putative substrate binding site [chemical binding]; other site 454166004928 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 454166004929 putative GSH binding site [chemical binding]; other site 454166004930 catalytic residues [active] 454166004931 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 454166004932 NlpC/P60 family; Region: NLPC_P60; pfam00877 454166004933 superoxide dismutase; Provisional; Region: PRK10543 454166004934 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 454166004935 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 454166004936 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 454166004937 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166004938 DNA binding site [nucleotide binding] 454166004939 domain linker motif; other site 454166004940 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 454166004941 dimerization interface [polypeptide binding]; other site 454166004942 ligand binding site [chemical binding]; other site 454166004943 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 454166004944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166004945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166004946 dimerization interface [polypeptide binding]; other site 454166004947 putative transporter; Provisional; Region: PRK11043 454166004948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166004949 putative substrate translocation pore; other site 454166004950 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 454166004951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166004952 S-adenosylmethionine binding site [chemical binding]; other site 454166004953 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 454166004954 Lumazine binding domain; Region: Lum_binding; pfam00677 454166004955 Lumazine binding domain; Region: Lum_binding; pfam00677 454166004956 multidrug efflux protein; Reviewed; Region: PRK01766 454166004957 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 454166004958 cation binding site [ion binding]; other site 454166004959 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 454166004960 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 454166004961 type III secretion system protein SsaT; Provisional; Region: PRK15349 454166004962 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 454166004963 type III secretion system protein SsaQ; Validated; Region: PRK08035 454166004964 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 454166004965 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 454166004966 type III secretion system protein SsaP; Provisional; Region: PRK15351 454166004967 type III secretion system protein SsaO; Provisional; Region: PRK15352 454166004968 type III secretion system ATPase SsaN; Validated; Region: PRK07594 454166004969 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 454166004970 Walker A motif; other site 454166004971 ATP binding site [chemical binding]; other site 454166004972 Walker B motif; other site 454166004973 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 454166004974 FHIPEP family; Region: FHIPEP; pfam00771 454166004975 type III secretion system protein SsaM; Provisional; Region: PRK15353 454166004976 type III secretion system protein SsaL; Provisional; Region: PRK15345 454166004977 HrpJ-like domain; Region: HrpJ; pfam07201 454166004978 TyeA; Region: TyeA; cl07611 454166004979 type III secretion system protein SsaK; Provisional; Region: PRK15354 454166004980 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 454166004981 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 454166004982 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 454166004983 type III secretion system protein SsaI; Provisional; Region: PRK15355 454166004984 type III secretion system protein SsaH; Provisional; Region: PRK15356 454166004985 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 454166004986 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 454166004987 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 454166004988 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 454166004989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166004990 TPR motif; other site 454166004991 binding surface 454166004992 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 454166004993 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 454166004994 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 454166004995 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 454166004996 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 454166004997 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 454166004998 type III secretion system protein SsaD; Provisional; Region: PRK15367 454166004999 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 454166005000 outer membrane secretin SsaC; Provisional; Region: PRK15346 454166005001 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 454166005002 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 454166005003 two component system sensor kinase SsrA; Provisional; Region: PRK15347 454166005004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166005005 dimerization interface [polypeptide binding]; other site 454166005006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166005007 dimer interface [polypeptide binding]; other site 454166005008 phosphorylation site [posttranslational modification] 454166005009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166005010 ATP binding site [chemical binding]; other site 454166005011 Mg2+ binding site [ion binding]; other site 454166005012 G-X-G motif; other site 454166005013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166005014 active site 454166005015 phosphorylation site [posttranslational modification] 454166005016 intermolecular recognition site; other site 454166005017 dimerization interface [polypeptide binding]; other site 454166005018 two component system sensor kinase SsrB; Provisional; Region: PRK15369 454166005019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166005020 active site 454166005021 phosphorylation site [posttranslational modification] 454166005022 intermolecular recognition site; other site 454166005023 dimerization interface [polypeptide binding]; other site 454166005024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166005025 DNA binding residues [nucleotide binding] 454166005026 dimerization interface [polypeptide binding]; other site 454166005027 transcriptional regulator MirA; Provisional; Region: PRK15043 454166005028 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 454166005029 DNA binding residues [nucleotide binding] 454166005030 Uncharacterized conserved protein [Function unknown]; Region: COG1683 454166005031 Uncharacterized conserved protein [Function unknown]; Region: COG3272 454166005032 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 454166005033 hypothetical protein; Provisional; Region: PRK10292 454166005034 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 454166005035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166005036 active site 454166005037 phosphorylation site [posttranslational modification] 454166005038 intermolecular recognition site; other site 454166005039 dimerization interface [polypeptide binding]; other site 454166005040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166005041 DNA binding residues [nucleotide binding] 454166005042 dimerization interface [polypeptide binding]; other site 454166005043 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 454166005044 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 454166005045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 454166005046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166005047 dimer interface [polypeptide binding]; other site 454166005048 phosphorylation site [posttranslational modification] 454166005049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166005050 ATP binding site [chemical binding]; other site 454166005051 Mg2+ binding site [ion binding]; other site 454166005052 G-X-G motif; other site 454166005053 tetrathionate reductase subunit B; Provisional; Region: PRK14993 454166005054 4Fe-4S binding domain; Region: Fer4; pfam00037 454166005055 tetrathionate reductase subunit C; Provisional; Region: PRK14992 454166005056 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 454166005057 tetrathionate reductase subunit A; Provisional; Region: PRK14991 454166005058 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 454166005059 putative [Fe4-S4] binding site [ion binding]; other site 454166005060 putative molybdopterin cofactor binding site [chemical binding]; other site 454166005061 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 454166005062 putative molybdopterin cofactor binding site; other site 454166005063 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166005064 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454166005065 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166005066 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454166005067 substrate binding site [chemical binding]; other site 454166005068 dimer interface [polypeptide binding]; other site 454166005069 ATP binding site [chemical binding]; other site 454166005070 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 454166005071 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 454166005072 pyruvate kinase; Provisional; Region: PRK09206 454166005073 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 454166005074 domain interfaces; other site 454166005075 active site 454166005076 murein lipoprotein; Provisional; Region: PRK15396 454166005077 murein lipoprotein; Provisional; Region: PRK15396 454166005078 L,D-transpeptidase; Provisional; Region: PRK10190 454166005079 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166005080 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454166005081 cysteine desufuration protein SufE; Provisional; Region: PRK09296 454166005082 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 454166005083 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 454166005084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166005085 catalytic residue [active] 454166005086 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 454166005087 FeS assembly protein SufD; Region: sufD; TIGR01981 454166005088 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 454166005089 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 454166005090 Walker A/P-loop; other site 454166005091 ATP binding site [chemical binding]; other site 454166005092 Q-loop/lid; other site 454166005093 ABC transporter signature motif; other site 454166005094 Walker B; other site 454166005095 D-loop; other site 454166005096 H-loop/switch region; other site 454166005097 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 454166005098 putative ABC transporter; Region: ycf24; CHL00085 454166005099 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 454166005100 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 454166005101 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454166005102 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 454166005103 CoenzymeA binding site [chemical binding]; other site 454166005104 subunit interaction site [polypeptide binding]; other site 454166005105 PHB binding site; other site 454166005106 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 454166005107 FAD binding domain; Region: FAD_binding_4; pfam01565 454166005108 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 454166005109 putative inner membrane protein; Provisional; Region: PRK10983 454166005110 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454166005111 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 454166005112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166005113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166005114 putative substrate translocation pore; other site 454166005115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166005116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166005117 putative substrate translocation pore; other site 454166005118 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 454166005119 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 454166005120 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 454166005121 shikimate binding site; other site 454166005122 NAD(P) binding site [chemical binding]; other site 454166005123 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 454166005124 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 454166005125 active site 454166005126 catalytic residue [active] 454166005127 dimer interface [polypeptide binding]; other site 454166005128 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 454166005129 Coenzyme A transferase; Region: CoA_trans; smart00882 454166005130 Coenzyme A transferase; Region: CoA_trans; cl17247 454166005131 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 454166005132 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 454166005133 active site 454166005134 Cupin domain; Region: Cupin_2; pfam07883 454166005135 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166005136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166005137 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 454166005138 Ligand binding site [chemical binding]; other site 454166005139 Electron transfer flavoprotein domain; Region: ETF; pfam01012 454166005140 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 454166005141 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 454166005142 Ligand binding site [chemical binding]; other site 454166005143 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 454166005144 oxidoreductase; Provisional; Region: PRK10015 454166005145 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 454166005146 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 454166005147 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 454166005148 acyl-activating enzyme (AAE) consensus motif; other site 454166005149 putative AMP binding site [chemical binding]; other site 454166005150 putative active site [active] 454166005151 putative CoA binding site [chemical binding]; other site 454166005152 phosphoenolpyruvate synthase; Validated; Region: PRK06464 454166005153 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 454166005154 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 454166005155 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 454166005156 PEP synthetase regulatory protein; Provisional; Region: PRK05339 454166005157 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 454166005158 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454166005159 hypothetical protein; Provisional; Region: PRK10183 454166005160 Uncharacterized conserved protein [Function unknown]; Region: COG0397 454166005161 hypothetical protein; Validated; Region: PRK00029 454166005162 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 454166005163 NlpC/P60 family; Region: NLPC_P60; pfam00877 454166005164 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 454166005165 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 454166005166 Walker A/P-loop; other site 454166005167 ATP binding site [chemical binding]; other site 454166005168 Q-loop/lid; other site 454166005169 ABC transporter signature motif; other site 454166005170 Walker B; other site 454166005171 D-loop; other site 454166005172 H-loop/switch region; other site 454166005173 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 454166005174 catalytic residues [active] 454166005175 dimer interface [polypeptide binding]; other site 454166005176 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 454166005177 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166005178 ABC-ATPase subunit interface; other site 454166005179 dimer interface [polypeptide binding]; other site 454166005180 putative PBP binding regions; other site 454166005181 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454166005182 IHF dimer interface [polypeptide binding]; other site 454166005183 IHF - DNA interface [nucleotide binding]; other site 454166005184 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 454166005185 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 454166005186 putative tRNA-binding site [nucleotide binding]; other site 454166005187 B3/4 domain; Region: B3_4; pfam03483 454166005188 tRNA synthetase B5 domain; Region: B5; smart00874 454166005189 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 454166005190 dimer interface [polypeptide binding]; other site 454166005191 motif 1; other site 454166005192 motif 3; other site 454166005193 motif 2; other site 454166005194 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 454166005195 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 454166005196 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 454166005197 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 454166005198 dimer interface [polypeptide binding]; other site 454166005199 motif 1; other site 454166005200 active site 454166005201 motif 2; other site 454166005202 motif 3; other site 454166005203 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 454166005204 23S rRNA binding site [nucleotide binding]; other site 454166005205 L21 binding site [polypeptide binding]; other site 454166005206 L13 binding site [polypeptide binding]; other site 454166005207 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 454166005208 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 454166005209 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 454166005210 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 454166005211 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 454166005212 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 454166005213 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 454166005214 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 454166005215 active site 454166005216 dimer interface [polypeptide binding]; other site 454166005217 motif 1; other site 454166005218 motif 2; other site 454166005219 motif 3; other site 454166005220 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 454166005221 anticodon binding site; other site 454166005222 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 454166005223 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 454166005224 active site 454166005225 substrate binding site [chemical binding]; other site 454166005226 Mg2+ binding site [ion binding]; other site 454166005227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 454166005228 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 454166005229 6-phosphofructokinase 2; Provisional; Region: PRK10294 454166005230 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 454166005231 putative substrate binding site [chemical binding]; other site 454166005232 putative ATP binding site [chemical binding]; other site 454166005233 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 454166005234 Phosphotransferase enzyme family; Region: APH; pfam01636 454166005235 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 454166005236 active site 454166005237 ATP binding site [chemical binding]; other site 454166005238 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 454166005239 YniB-like protein; Region: YniB; pfam14002 454166005240 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 454166005241 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 454166005242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166005243 motif II; other site 454166005244 inner membrane protein; Provisional; Region: PRK11648 454166005245 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 454166005246 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454166005247 cell division modulator; Provisional; Region: PRK10113 454166005248 hydroperoxidase II; Provisional; Region: katE; PRK11249 454166005249 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 454166005250 tetramer interface [polypeptide binding]; other site 454166005251 heme binding pocket [chemical binding]; other site 454166005252 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 454166005253 domain interactions; other site 454166005254 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 454166005255 putative active site [active] 454166005256 YdjC motif; other site 454166005257 Mg binding site [ion binding]; other site 454166005258 putative homodimer interface [polypeptide binding]; other site 454166005259 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 454166005260 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 454166005261 NAD binding site [chemical binding]; other site 454166005262 sugar binding site [chemical binding]; other site 454166005263 divalent metal binding site [ion binding]; other site 454166005264 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454166005265 dimer interface [polypeptide binding]; other site 454166005266 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 454166005267 Cupin domain; Region: Cupin_2; pfam07883 454166005268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166005269 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 454166005270 methionine cluster; other site 454166005271 active site 454166005272 phosphorylation site [posttranslational modification] 454166005273 metal binding site [ion binding]; metal-binding site 454166005274 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 454166005275 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 454166005276 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 454166005277 active site 454166005278 P-loop; other site 454166005279 phosphorylation site [posttranslational modification] 454166005280 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 454166005281 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 454166005282 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 454166005283 homodimer interface [polypeptide binding]; other site 454166005284 NAD binding pocket [chemical binding]; other site 454166005285 ATP binding pocket [chemical binding]; other site 454166005286 Mg binding site [ion binding]; other site 454166005287 active-site loop [active] 454166005288 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 454166005289 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 454166005290 GIY-YIG motif/motif A; other site 454166005291 active site 454166005292 catalytic site [active] 454166005293 putative DNA binding site [nucleotide binding]; other site 454166005294 metal binding site [ion binding]; metal-binding site 454166005295 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454166005296 dimer interface [polypeptide binding]; other site 454166005297 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 454166005298 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 454166005299 putative active site [active] 454166005300 Zn binding site [ion binding]; other site 454166005301 succinylarginine dihydrolase; Provisional; Region: PRK13281 454166005302 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 454166005303 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 454166005304 NAD(P) binding site [chemical binding]; other site 454166005305 catalytic residues [active] 454166005306 arginine succinyltransferase; Provisional; Region: PRK10456 454166005307 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 454166005308 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 454166005309 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454166005310 inhibitor-cofactor binding pocket; inhibition site 454166005311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166005312 catalytic residue [active] 454166005313 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 454166005314 putative catalytic site [active] 454166005315 putative phosphate binding site [ion binding]; other site 454166005316 active site 454166005317 metal binding site A [ion binding]; metal-binding site 454166005318 DNA binding site [nucleotide binding] 454166005319 putative AP binding site [nucleotide binding]; other site 454166005320 putative metal binding site B [ion binding]; other site 454166005321 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 454166005322 active site 454166005323 8-oxo-dGMP binding site [chemical binding]; other site 454166005324 nudix motif; other site 454166005325 metal binding site [ion binding]; metal-binding site 454166005326 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 454166005327 glutamate dehydrogenase; Provisional; Region: PRK09414 454166005328 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 454166005329 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 454166005330 NAD(P) binding site [chemical binding]; other site 454166005331 DNA topoisomerase III; Provisional; Region: PRK07726 454166005332 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 454166005333 active site 454166005334 putative interdomain interaction site [polypeptide binding]; other site 454166005335 putative metal-binding site [ion binding]; other site 454166005336 putative nucleotide binding site [chemical binding]; other site 454166005337 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 454166005338 domain I; other site 454166005339 DNA binding groove [nucleotide binding] 454166005340 phosphate binding site [ion binding]; other site 454166005341 domain II; other site 454166005342 domain III; other site 454166005343 nucleotide binding site [chemical binding]; other site 454166005344 catalytic site [active] 454166005345 domain IV; other site 454166005346 selenophosphate synthetase; Provisional; Region: PRK00943 454166005347 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 454166005348 dimerization interface [polypeptide binding]; other site 454166005349 putative ATP binding site [chemical binding]; other site 454166005350 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 454166005351 putative FMN binding site [chemical binding]; other site 454166005352 protease 4; Provisional; Region: PRK10949 454166005353 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 454166005354 tandem repeat interface [polypeptide binding]; other site 454166005355 oligomer interface [polypeptide binding]; other site 454166005356 active site residues [active] 454166005357 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 454166005358 tandem repeat interface [polypeptide binding]; other site 454166005359 oligomer interface [polypeptide binding]; other site 454166005360 active site residues [active] 454166005361 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 454166005362 active site 454166005363 homodimer interface [polypeptide binding]; other site 454166005364 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 454166005365 Isochorismatase family; Region: Isochorismatase; pfam00857 454166005366 catalytic triad [active] 454166005367 metal binding site [ion binding]; metal-binding site 454166005368 conserved cis-peptide bond; other site 454166005369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 454166005370 methionine sulfoxide reductase B; Provisional; Region: PRK00222 454166005371 SelR domain; Region: SelR; pfam01641 454166005372 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 454166005373 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 454166005374 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 454166005375 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 454166005376 active site 454166005377 phosphate binding residues; other site 454166005378 catalytic residues [active] 454166005379 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166005380 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166005381 active site 454166005382 catalytic tetrad [active] 454166005383 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 454166005384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166005385 FeS/SAM binding site; other site 454166005386 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454166005387 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 454166005388 PrkA family serine protein kinase; Provisional; Region: PRK15455 454166005389 AAA ATPase domain; Region: AAA_16; pfam13191 454166005390 Walker A motif; other site 454166005391 ATP binding site [chemical binding]; other site 454166005392 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 454166005393 hypothetical protein; Provisional; Region: PRK05325 454166005394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454166005395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166005396 metal binding site [ion binding]; metal-binding site 454166005397 active site 454166005398 I-site; other site 454166005399 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 454166005400 putative deacylase active site [active] 454166005401 Predicted membrane protein [Function unknown]; Region: COG2707 454166005402 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 454166005403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166005404 Uncharacterized conserved protein [Function unknown]; Region: COG3189 454166005405 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 454166005406 murein hydrolase B; Provisional; Region: PRK10760; cl17906 454166005407 Domain of unknown function (DUF333); Region: DUF333; pfam03891 454166005408 hypothetical protein; Provisional; Region: PRK10457 454166005409 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 454166005410 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 454166005411 leucine export protein LeuE; Provisional; Region: PRK10958 454166005412 chorismate mutase; Provisional; Region: PRK08055 454166005413 Pleckstrin homology-like domain; Region: PH-like; cl17171 454166005414 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 454166005415 transcriptional regulator MirA; Provisional; Region: PRK15043 454166005416 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 454166005417 DNA binding residues [nucleotide binding] 454166005418 dimer interface [polypeptide binding]; other site 454166005419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166005420 DNA binding residues [nucleotide binding] 454166005421 aminoglycoside resistance protein; Provisional; Region: PRK13746 454166005422 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 454166005423 active site 454166005424 NTP binding site [chemical binding]; other site 454166005425 metal binding triad [ion binding]; metal-binding site 454166005426 antibiotic binding site [chemical binding]; other site 454166005427 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 454166005428 zinc/cadmium-binding protein; Provisional; Region: PRK10306 454166005429 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 454166005430 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166005431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166005432 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 454166005433 Walker A/P-loop; other site 454166005434 ATP binding site [chemical binding]; other site 454166005435 Q-loop/lid; other site 454166005436 ABC transporter signature motif; other site 454166005437 Walker B; other site 454166005438 D-loop; other site 454166005439 H-loop/switch region; other site 454166005440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166005441 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 454166005442 Walker A/P-loop; other site 454166005443 ATP binding site [chemical binding]; other site 454166005444 Q-loop/lid; other site 454166005445 ABC transporter signature motif; other site 454166005446 Walker B; other site 454166005447 D-loop; other site 454166005448 H-loop/switch region; other site 454166005449 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 454166005450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166005451 dimer interface [polypeptide binding]; other site 454166005452 conserved gate region; other site 454166005453 putative PBP binding loops; other site 454166005454 ABC-ATPase subunit interface; other site 454166005455 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 454166005456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166005457 dimer interface [polypeptide binding]; other site 454166005458 conserved gate region; other site 454166005459 ABC-ATPase subunit interface; other site 454166005460 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 454166005461 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 454166005462 TRL-like protein family; Region: TRL; pfam13146 454166005463 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 454166005464 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 454166005465 BNR repeat-like domain; Region: BNR_2; pfam13088 454166005466 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 454166005467 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 454166005468 putative dimer interface [polypeptide binding]; other site 454166005469 lysozyme inhibitor; Provisional; Region: PRK13791 454166005470 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 454166005471 Ricin-type beta-trefoil; Region: RICIN; smart00458 454166005472 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 454166005473 putative sugar binding sites [chemical binding]; other site 454166005474 Q-X-W motif; other site 454166005475 DinI-like family; Region: DinI; pfam06183 454166005476 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 454166005477 isocitrate dehydrogenase; Validated; Region: PRK07362 454166005478 isocitrate dehydrogenase; Reviewed; Region: PRK07006 454166005479 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 454166005480 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 454166005481 probable active site [active] 454166005482 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 454166005483 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 454166005484 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 454166005485 nudix motif; other site 454166005486 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 454166005487 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 454166005488 putative lysogenization regulator; Reviewed; Region: PRK00218 454166005489 adenylosuccinate lyase; Provisional; Region: PRK09285 454166005490 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 454166005491 tetramer interface [polypeptide binding]; other site 454166005492 active site 454166005493 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 454166005494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166005495 active site 454166005496 phosphorylation site [posttranslational modification] 454166005497 intermolecular recognition site; other site 454166005498 dimerization interface [polypeptide binding]; other site 454166005499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166005500 DNA binding site [nucleotide binding] 454166005501 sensor protein PhoQ; Provisional; Region: PRK10815 454166005502 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 454166005503 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 454166005504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166005505 ATP binding site [chemical binding]; other site 454166005506 Mg2+ binding site [ion binding]; other site 454166005507 G-X-G motif; other site 454166005508 Uncharacterized conserved protein [Function unknown]; Region: COG2850 454166005509 Cupin domain; Region: Cupin_2; cl17218 454166005510 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 454166005511 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 454166005512 metal binding site [ion binding]; metal-binding site 454166005513 dimer interface [polypeptide binding]; other site 454166005514 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 454166005515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166005516 Walker A/P-loop; other site 454166005517 ATP binding site [chemical binding]; other site 454166005518 Q-loop/lid; other site 454166005519 ABC transporter signature motif; other site 454166005520 Walker B; other site 454166005521 D-loop; other site 454166005522 H-loop/switch region; other site 454166005523 TOBE domain; Region: TOBE_2; pfam08402 454166005524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 454166005525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166005526 dimer interface [polypeptide binding]; other site 454166005527 conserved gate region; other site 454166005528 putative PBP binding loops; other site 454166005529 ABC-ATPase subunit interface; other site 454166005530 secreted effector protein SifA; Reviewed; Region: sifA; PRK09498 454166005531 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 454166005532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166005533 dimer interface [polypeptide binding]; other site 454166005534 conserved gate region; other site 454166005535 putative PBP binding loops; other site 454166005536 ABC-ATPase subunit interface; other site 454166005537 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 454166005538 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 454166005539 NAD-dependent deacetylase; Provisional; Region: PRK00481 454166005540 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 454166005541 NAD+ binding site [chemical binding]; other site 454166005542 substrate binding site [chemical binding]; other site 454166005543 Zn binding site [ion binding]; other site 454166005544 fructokinase; Reviewed; Region: PRK09557 454166005545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166005546 nucleotide binding site [chemical binding]; other site 454166005547 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 454166005548 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 454166005549 FtsX-like permease family; Region: FtsX; pfam02687 454166005550 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 454166005551 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 454166005552 Walker A/P-loop; other site 454166005553 ATP binding site [chemical binding]; other site 454166005554 Q-loop/lid; other site 454166005555 ABC transporter signature motif; other site 454166005556 Walker B; other site 454166005557 D-loop; other site 454166005558 H-loop/switch region; other site 454166005559 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 454166005560 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 454166005561 FtsX-like permease family; Region: FtsX; pfam02687 454166005562 transcription-repair coupling factor; Provisional; Region: PRK10689 454166005563 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 454166005564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166005565 ATP binding site [chemical binding]; other site 454166005566 putative Mg++ binding site [ion binding]; other site 454166005567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166005568 nucleotide binding region [chemical binding]; other site 454166005569 ATP-binding site [chemical binding]; other site 454166005570 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 454166005571 L,D-transpeptidase; Provisional; Region: PRK10190 454166005572 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166005573 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454166005574 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166005575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 454166005576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166005577 hypothetical protein; Provisional; Region: PRK11280 454166005578 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 454166005579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166005580 hypothetical protein; Provisional; Region: PRK04940 454166005581 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 454166005582 beta-hexosaminidase; Provisional; Region: PRK05337 454166005583 thiamine kinase; Region: ycfN_thiK; TIGR02721 454166005584 thiamine kinase; Provisional; Region: thiK; PRK10271 454166005585 substrate binding site [chemical binding]; other site 454166005586 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 454166005587 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 454166005588 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 454166005589 putative dimer interface [polypeptide binding]; other site 454166005590 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 454166005591 nucleotide binding site/active site [active] 454166005592 HIT family signature motif; other site 454166005593 catalytic residue [active] 454166005594 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 454166005595 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166005596 N-terminal plug; other site 454166005597 ligand-binding site [chemical binding]; other site 454166005598 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 454166005599 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454166005600 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454166005601 active site turn [active] 454166005602 phosphorylation site [posttranslational modification] 454166005603 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 454166005604 active site 454166005605 DNA polymerase III subunit delta'; Validated; Region: PRK07993 454166005606 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 454166005607 thymidylate kinase; Validated; Region: tmk; PRK00698 454166005608 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 454166005609 TMP-binding site; other site 454166005610 ATP-binding site [chemical binding]; other site 454166005611 conserved hypothetical protein, YceG family; Region: TIGR00247 454166005612 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 454166005613 dimerization interface [polypeptide binding]; other site 454166005614 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 454166005615 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 454166005616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166005617 catalytic residue [active] 454166005618 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 454166005619 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 454166005620 dimer interface [polypeptide binding]; other site 454166005621 active site 454166005622 acyl carrier protein; Provisional; Region: acpP; PRK00982 454166005623 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 454166005624 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 454166005625 NAD(P) binding site [chemical binding]; other site 454166005626 homotetramer interface [polypeptide binding]; other site 454166005627 homodimer interface [polypeptide binding]; other site 454166005628 active site 454166005629 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 454166005630 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 454166005631 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 454166005632 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 454166005633 dimer interface [polypeptide binding]; other site 454166005634 active site 454166005635 CoA binding pocket [chemical binding]; other site 454166005636 putative phosphate acyltransferase; Provisional; Region: PRK05331 454166005637 hypothetical protein; Provisional; Region: PRK11193 454166005638 Maf-like protein; Region: Maf; pfam02545 454166005639 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 454166005640 active site 454166005641 dimer interface [polypeptide binding]; other site 454166005642 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 454166005643 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 454166005644 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166005645 RNA binding surface [nucleotide binding]; other site 454166005646 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 454166005647 active site 454166005648 RNase E 5' UTR element 454166005649 ribonuclease E; Reviewed; Region: rne; PRK10811 454166005650 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 454166005651 homodimer interface [polypeptide binding]; other site 454166005652 oligonucleotide binding site [chemical binding]; other site 454166005653 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 454166005654 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 454166005655 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 454166005656 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 454166005657 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 454166005658 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 454166005659 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 454166005660 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 454166005661 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 454166005662 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 454166005663 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 454166005664 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 454166005665 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 454166005666 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454166005667 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 454166005668 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 454166005669 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454166005670 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 454166005671 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 454166005672 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454166005673 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 454166005674 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 454166005675 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 454166005676 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 454166005677 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 454166005678 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 454166005679 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 454166005680 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 454166005681 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 454166005682 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 454166005683 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 454166005684 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 454166005685 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 454166005686 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 454166005687 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 454166005688 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 454166005689 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 454166005690 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454166005691 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454166005692 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454166005693 hypothetical protein; Provisional; Region: PRK11239 454166005694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 454166005695 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 454166005696 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 454166005697 multidrug resistance protein MdtH; Provisional; Region: PRK11646 454166005698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166005699 putative substrate translocation pore; other site 454166005700 glutaredoxin 2; Provisional; Region: PRK10387 454166005701 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 454166005702 C-terminal domain interface [polypeptide binding]; other site 454166005703 GSH binding site (G-site) [chemical binding]; other site 454166005704 catalytic residues [active] 454166005705 putative dimer interface [polypeptide binding]; other site 454166005706 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 454166005707 N-terminal domain interface [polypeptide binding]; other site 454166005708 lipoprotein; Provisional; Region: PRK10598 454166005709 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 454166005710 active site 454166005711 substrate binding pocket [chemical binding]; other site 454166005712 dimer interface [polypeptide binding]; other site 454166005713 DNA damage-inducible protein I; Provisional; Region: PRK10597 454166005714 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 454166005715 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 454166005716 hydroxyglutarate oxidase; Provisional; Region: PRK11728 454166005717 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 454166005718 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 454166005719 hypothetical protein; Provisional; Region: PRK03757 454166005720 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 454166005721 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 454166005722 active site residue [active] 454166005723 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 454166005724 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 454166005725 putative acyl-acceptor binding pocket; other site 454166005726 drug efflux system protein MdtG; Provisional; Region: PRK09874 454166005727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166005728 putative substrate translocation pore; other site 454166005729 secY/secA suppressor protein; Provisional; Region: PRK11467 454166005730 lipoprotein; Provisional; Region: PRK10175 454166005731 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 454166005732 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 454166005733 Ligand binding site; other site 454166005734 DXD motif; other site 454166005735 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 454166005736 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 454166005737 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 454166005738 Acyltransferase family; Region: Acyl_transf_3; pfam01757 454166005739 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 454166005740 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 454166005741 putative active site [active] 454166005742 catalytic site [active] 454166005743 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 454166005744 putative active site [active] 454166005745 catalytic site [active] 454166005746 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 454166005747 putative ADP-ribose binding site [chemical binding]; other site 454166005748 putative active site [active] 454166005749 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 454166005750 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 454166005751 major curlin subunit; Provisional; Region: csgA; PRK10051 454166005752 Curlin associated repeat; Region: Curlin_rpt; pfam07012 454166005753 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 454166005754 Curlin associated repeat; Region: Curlin_rpt; pfam07012 454166005755 Curlin associated repeat; Region: Curlin_rpt; pfam07012 454166005756 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 454166005757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166005758 DNA binding residues [nucleotide binding] 454166005759 dimerization interface [polypeptide binding]; other site 454166005760 curli assembly protein CsgE; Provisional; Region: PRK10386 454166005761 curli assembly protein CsgF; Provisional; Region: PRK10050 454166005762 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 454166005763 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 454166005764 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 454166005765 putative hydrolase; Validated; Region: PRK09248 454166005766 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 454166005767 active site 454166005768 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 454166005769 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 454166005770 putative ligand binding site [chemical binding]; other site 454166005771 NAD binding site [chemical binding]; other site 454166005772 dimerization interface [polypeptide binding]; other site 454166005773 catalytic site [active] 454166005774 Helix-turn-helix domain; Region: HTH_28; pfam13518 454166005775 Integrase core domain; Region: rve; pfam00665 454166005776 Integrase core domain; Region: rve_3; pfam13683 454166005777 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 454166005778 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 454166005779 integrase; Provisional; Region: PRK09692 454166005780 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 454166005781 active site 454166005782 Int/Topo IB signature motif; other site 454166005783 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 454166005784 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 454166005785 synthetase active site [active] 454166005786 NTP binding site [chemical binding]; other site 454166005787 metal binding site [ion binding]; metal-binding site 454166005788 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 454166005789 PilS N terminal; Region: PilS; pfam08805 454166005790 Conjugal transfer protein TraD; Region: TraD; pfam06412 454166005791 MobA/MobL family; Region: MobA_MobL; pfam03389 454166005792 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 454166005793 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 454166005794 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 454166005795 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 454166005796 Integrase; Region: Integrase_1; pfam12835 454166005797 RES domain; Region: RES; smart00953 454166005798 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 454166005799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166005800 binding surface 454166005801 TPR motif; other site 454166005802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 454166005803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166005804 TPR motif; other site 454166005805 TPR repeat; Region: TPR_11; pfam13414 454166005806 binding surface 454166005807 putative protease; Region: PHA00666 454166005808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 454166005809 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166005810 Sel1-like repeats; Region: SEL1; smart00671 454166005811 Sel1-like repeats; Region: SEL1; smart00671 454166005812 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 454166005813 AMP nucleosidase; Provisional; Region: PRK08292 454166005814 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 454166005815 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 454166005816 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 454166005817 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 454166005818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454166005819 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 454166005820 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 454166005821 P loop; other site 454166005822 Nucleotide binding site [chemical binding]; other site 454166005823 DTAP/Switch II; other site 454166005824 Switch I; other site 454166005825 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 454166005826 P loop; other site 454166005827 Nucleotide binding site [chemical binding]; other site 454166005828 DTAP/Switch II; other site 454166005829 Switch I; other site 454166005830 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 454166005831 Low molecular weight phosphatase family; Region: LMWPc; cd00115 454166005832 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 454166005833 active site 454166005834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166005835 dimerization interface [polypeptide binding]; other site 454166005836 putative DNA binding site [nucleotide binding]; other site 454166005837 putative Zn2+ binding site [ion binding]; other site 454166005838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166005839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166005840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166005841 dimerization interface [polypeptide binding]; other site 454166005842 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 454166005843 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 454166005844 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 454166005845 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 454166005846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 454166005847 active site 454166005848 AMP binding site [chemical binding]; other site 454166005849 acyl-activating enzyme (AAE) consensus motif; other site 454166005850 CoA binding site [chemical binding]; other site 454166005851 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 454166005852 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 454166005853 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166005854 catalytic residue [active] 454166005855 L,D-transpeptidase; Provisional; Region: PRK10190 454166005856 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 454166005857 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 454166005858 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 454166005859 putative dimer interface [polypeptide binding]; other site 454166005860 active site pocket [active] 454166005861 putative cataytic base [active] 454166005862 cobalamin synthase; Reviewed; Region: cobS; PRK00235 454166005863 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 454166005864 homotrimer interface [polypeptide binding]; other site 454166005865 Walker A motif; other site 454166005866 GTP binding site [chemical binding]; other site 454166005867 Walker B motif; other site 454166005868 cobyric acid synthase; Provisional; Region: PRK00784 454166005869 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 454166005870 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 454166005871 catalytic triad [active] 454166005872 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 454166005873 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 454166005874 Walker A/P-loop; other site 454166005875 ATP binding site [chemical binding]; other site 454166005876 Q-loop/lid; other site 454166005877 ABC transporter signature motif; other site 454166005878 Walker B; other site 454166005879 D-loop; other site 454166005880 H-loop/switch region; other site 454166005881 cobalt transport protein CbiQ; Provisional; Region: PRK15485 454166005882 cobalt transport protein CbiN; Provisional; Region: PRK02898 454166005883 cobalt transport protein CbiM; Validated; Region: PRK08319 454166005884 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 454166005885 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 454166005886 active site 454166005887 SAM binding site [chemical binding]; other site 454166005888 homodimer interface [polypeptide binding]; other site 454166005889 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 454166005890 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 454166005891 active site 454166005892 C-terminal domain interface [polypeptide binding]; other site 454166005893 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 454166005894 active site 454166005895 N-terminal domain interface [polypeptide binding]; other site 454166005896 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 454166005897 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 454166005898 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 454166005899 active site 454166005900 SAM binding site [chemical binding]; other site 454166005901 homodimer interface [polypeptide binding]; other site 454166005902 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 454166005903 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 454166005904 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 454166005905 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 454166005906 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 454166005907 active site 454166005908 SAM binding site [chemical binding]; other site 454166005909 homodimer interface [polypeptide binding]; other site 454166005910 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 454166005911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166005912 S-adenosylmethionine binding site [chemical binding]; other site 454166005913 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 454166005914 active site 454166005915 putative homodimer interface [polypeptide binding]; other site 454166005916 SAM binding site [chemical binding]; other site 454166005917 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 454166005918 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 454166005919 Precorrin-8X methylmutase; Region: CbiC; pfam02570 454166005920 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 454166005921 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 454166005922 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 454166005923 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 454166005924 catalytic triad [active] 454166005925 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 454166005926 Sensory domain found in PocR; Region: PocR; pfam10114 454166005927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166005928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166005929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166005930 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 454166005931 amphipathic channel; other site 454166005932 Asn-Pro-Ala signature motifs; other site 454166005933 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 454166005934 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 454166005935 Hexamer interface [polypeptide binding]; other site 454166005936 Putative hexagonal pore residue; other site 454166005937 propanediol utilization protein PduB; Provisional; Region: PRK15415 454166005938 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 454166005939 putative hexamer interface [polypeptide binding]; other site 454166005940 putative hexagonal pore; other site 454166005941 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 454166005942 putative hexamer interface [polypeptide binding]; other site 454166005943 putative hexagonal pore; other site 454166005944 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 454166005945 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 454166005946 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 454166005947 alpha-beta subunit interface [polypeptide binding]; other site 454166005948 alpha-gamma subunit interface [polypeptide binding]; other site 454166005949 active site 454166005950 substrate and K+ binding site; other site 454166005951 K+ binding site [ion binding]; other site 454166005952 cobalamin binding site [chemical binding]; other site 454166005953 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 454166005954 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 454166005955 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 454166005956 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 454166005957 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 454166005958 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 454166005959 Hexamer interface [polypeptide binding]; other site 454166005960 Putative hexagonal pore residue; other site 454166005961 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 454166005962 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 454166005963 putative hexamer interface [polypeptide binding]; other site 454166005964 putative hexagonal pore; other site 454166005965 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 454166005966 Propanediol utilisation protein PduL; Region: PduL; pfam06130 454166005967 Propanediol utilisation protein PduL; Region: PduL; pfam06130 454166005968 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 454166005969 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 454166005970 Hexamer/Pentamer interface [polypeptide binding]; other site 454166005971 central pore; other site 454166005972 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 454166005973 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 454166005974 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 454166005975 putative catalytic cysteine [active] 454166005976 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 454166005977 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 454166005978 putative active site [active] 454166005979 metal binding site [ion binding]; metal-binding site 454166005980 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 454166005981 SLBB domain; Region: SLBB; pfam10531 454166005982 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 454166005983 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 454166005984 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 454166005985 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 454166005986 putative hexamer interface [polypeptide binding]; other site 454166005987 putative hexagonal pore; other site 454166005988 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 454166005989 putative hexamer interface [polypeptide binding]; other site 454166005990 putative hexagonal pore; other site 454166005991 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 454166005992 putative hexamer interface [polypeptide binding]; other site 454166005993 putative hexagonal pore; other site 454166005994 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 454166005995 G3 box; other site 454166005996 Switch II region; other site 454166005997 GTP/Mg2+ binding site [chemical binding]; other site 454166005998 G4 box; other site 454166005999 G5 box; other site 454166006000 propionate kinase; Reviewed; Region: PRK12397 454166006001 propionate/acetate kinase; Provisional; Region: PRK12379 454166006002 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 454166006003 hypothetical protein; Provisional; Region: PRK05423 454166006004 Predicted membrane protein [Function unknown]; Region: COG1289 454166006005 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454166006006 DNA gyrase inhibitor; Provisional; Region: PRK10016 454166006007 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 454166006008 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 454166006009 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 454166006010 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 454166006011 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 454166006012 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 454166006013 4Fe-4S binding domain; Region: Fer4; cl02805 454166006014 thiosulfate reductase PhsA; Provisional; Region: PRK15488 454166006015 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 454166006016 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 454166006017 putative [Fe4-S4] binding site [ion binding]; other site 454166006018 putative molybdopterin cofactor binding site [chemical binding]; other site 454166006019 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 454166006020 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 454166006021 putative molybdopterin cofactor binding site; other site 454166006022 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 454166006023 SopA-like central domain; Region: SopA; pfam13981 454166006024 SopA-like catalytic domain; Region: SopA_C; pfam13979 454166006025 exonuclease I; Provisional; Region: sbcB; PRK11779 454166006026 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 454166006027 active site 454166006028 catalytic site [active] 454166006029 substrate binding site [chemical binding]; other site 454166006030 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 454166006031 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 454166006032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166006033 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 454166006034 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166006035 dimerization interface [polypeptide binding]; other site 454166006036 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 454166006037 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 454166006038 putative NAD(P) binding site [chemical binding]; other site 454166006039 Histidine operon leader 454166006040 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 454166006041 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 454166006042 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 454166006043 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 454166006044 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 454166006045 NAD binding site [chemical binding]; other site 454166006046 dimerization interface [polypeptide binding]; other site 454166006047 product binding site; other site 454166006048 substrate binding site [chemical binding]; other site 454166006049 zinc binding site [ion binding]; other site 454166006050 catalytic residues [active] 454166006051 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 454166006052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166006053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166006054 homodimer interface [polypeptide binding]; other site 454166006055 catalytic residue [active] 454166006056 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 454166006057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166006058 active site 454166006059 motif I; other site 454166006060 motif II; other site 454166006061 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 454166006062 putative active site pocket [active] 454166006063 4-fold oligomerization interface [polypeptide binding]; other site 454166006064 metal binding residues [ion binding]; metal-binding site 454166006065 3-fold/trimer interface [polypeptide binding]; other site 454166006066 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 454166006067 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 454166006068 putative active site [active] 454166006069 oxyanion strand; other site 454166006070 catalytic triad [active] 454166006071 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 454166006072 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 454166006073 catalytic residues [active] 454166006074 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 454166006075 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 454166006076 substrate binding site [chemical binding]; other site 454166006077 glutamase interaction surface [polypeptide binding]; other site 454166006078 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 454166006079 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 454166006080 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 454166006081 metal binding site [ion binding]; metal-binding site 454166006082 chain length determinant protein WzzB; Provisional; Region: PRK15471 454166006083 Chain length determinant protein; Region: Wzz; cl15801 454166006084 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 454166006085 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 454166006086 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 454166006087 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 454166006088 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 454166006089 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454166006090 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 454166006091 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 454166006092 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 454166006093 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 454166006094 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 454166006095 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 454166006096 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 454166006097 active site 454166006098 substrate binding site [chemical binding]; other site 454166006099 metal binding site [ion binding]; metal-binding site 454166006100 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 454166006101 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 454166006102 Substrate binding site; other site 454166006103 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 454166006104 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 454166006105 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 454166006106 active site 454166006107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454166006108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 454166006109 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 454166006110 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 454166006111 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 454166006112 active site 454166006113 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 454166006114 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 454166006115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 454166006116 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 454166006117 NAD(P) binding site [chemical binding]; other site 454166006118 active site 454166006119 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 454166006120 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 454166006121 inhibitor-cofactor binding pocket; inhibition site 454166006122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166006123 catalytic residue [active] 454166006124 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 454166006125 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 454166006126 NAD binding site [chemical binding]; other site 454166006127 homotetramer interface [polypeptide binding]; other site 454166006128 homodimer interface [polypeptide binding]; other site 454166006129 substrate binding site [chemical binding]; other site 454166006130 active site 454166006131 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 454166006132 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 454166006133 substrate binding site; other site 454166006134 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 454166006135 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454166006136 catalytic loop [active] 454166006137 iron binding site [ion binding]; other site 454166006138 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 454166006139 FAD binding pocket [chemical binding]; other site 454166006140 FAD binding motif [chemical binding]; other site 454166006141 phosphate binding motif [ion binding]; other site 454166006142 beta-alpha-beta structure motif; other site 454166006143 NAD binding pocket [chemical binding]; other site 454166006144 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 454166006145 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 454166006146 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 454166006147 substrate binding site; other site 454166006148 tetramer interface; other site 454166006149 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 454166006150 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 454166006151 NADP binding site [chemical binding]; other site 454166006152 active site 454166006153 putative substrate binding site [chemical binding]; other site 454166006154 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 454166006155 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 454166006156 NAD binding site [chemical binding]; other site 454166006157 substrate binding site [chemical binding]; other site 454166006158 homodimer interface [polypeptide binding]; other site 454166006159 active site 454166006160 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 454166006161 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 454166006162 active site 454166006163 tetramer interface; other site 454166006164 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 454166006165 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 454166006166 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 454166006167 putative ADP-binding pocket [chemical binding]; other site 454166006168 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 454166006169 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 454166006170 colanic acid exporter; Provisional; Region: PRK10459 454166006171 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 454166006172 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 454166006173 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 454166006174 phosphomannomutase CpsG; Provisional; Region: PRK15414 454166006175 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 454166006176 active site 454166006177 substrate binding site [chemical binding]; other site 454166006178 metal binding site [ion binding]; metal-binding site 454166006179 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 454166006180 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 454166006181 Substrate binding site; other site 454166006182 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 454166006183 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 454166006184 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 454166006185 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 454166006186 active site 454166006187 GDP-Mannose binding site [chemical binding]; other site 454166006188 dimer interface [polypeptide binding]; other site 454166006189 modified nudix motif 454166006190 metal binding site [ion binding]; metal-binding site 454166006191 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 454166006192 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 454166006193 NADP binding site [chemical binding]; other site 454166006194 active site 454166006195 putative substrate binding site [chemical binding]; other site 454166006196 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 454166006197 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 454166006198 NADP-binding site; other site 454166006199 homotetramer interface [polypeptide binding]; other site 454166006200 substrate binding site [chemical binding]; other site 454166006201 homodimer interface [polypeptide binding]; other site 454166006202 active site 454166006203 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 454166006204 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 454166006205 putative trimer interface [polypeptide binding]; other site 454166006206 putative active site [active] 454166006207 putative substrate binding site [chemical binding]; other site 454166006208 putative CoA binding site [chemical binding]; other site 454166006209 putative glycosyl transferase; Provisional; Region: PRK10063 454166006210 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 454166006211 metal-binding site 454166006212 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 454166006213 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 454166006214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 454166006215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 454166006216 putative acyl transferase; Provisional; Region: PRK10191 454166006217 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 454166006218 trimer interface [polypeptide binding]; other site 454166006219 active site 454166006220 substrate binding site [chemical binding]; other site 454166006221 CoA binding site [chemical binding]; other site 454166006222 putative glycosyl transferase; Provisional; Region: PRK10018 454166006223 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 454166006224 active site 454166006225 tyrosine kinase; Provisional; Region: PRK11519 454166006226 Chain length determinant protein; Region: Wzz; pfam02706 454166006227 Chain length determinant protein; Region: Wzz; cl15801 454166006228 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 454166006229 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 454166006230 Low molecular weight phosphatase family; Region: LMWPc; cd00115 454166006231 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 454166006232 active site 454166006233 polysaccharide export protein Wza; Provisional; Region: PRK15078 454166006234 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 454166006235 putative assembly protein; Provisional; Region: PRK10833 454166006236 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 454166006237 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 454166006238 trimer interface [polypeptide binding]; other site 454166006239 active site 454166006240 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 454166006241 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 454166006242 ATP-binding site [chemical binding]; other site 454166006243 Sugar specificity; other site 454166006244 Pyrimidine base specificity; other site 454166006245 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 454166006246 PAS domain S-box; Region: sensory_box; TIGR00229 454166006247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166006248 putative active site [active] 454166006249 heme pocket [chemical binding]; other site 454166006250 PAS domain S-box; Region: sensory_box; TIGR00229 454166006251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166006252 putative active site [active] 454166006253 heme pocket [chemical binding]; other site 454166006254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454166006255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166006256 metal binding site [ion binding]; metal-binding site 454166006257 active site 454166006258 I-site; other site 454166006259 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166006260 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 454166006261 AlkA N-terminal domain; Region: AlkA_N; pfam06029 454166006262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 454166006263 minor groove reading motif; other site 454166006264 helix-hairpin-helix signature motif; other site 454166006265 substrate binding pocket [chemical binding]; other site 454166006266 active site 454166006267 putative chaperone; Provisional; Region: PRK11678 454166006268 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 454166006269 nucleotide binding site [chemical binding]; other site 454166006270 putative NEF/HSP70 interaction site [polypeptide binding]; other site 454166006271 SBD interface [polypeptide binding]; other site 454166006272 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 454166006273 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166006274 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166006275 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 454166006276 Protein export membrane protein; Region: SecD_SecF; cl14618 454166006277 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 454166006278 putative transporter; Provisional; Region: PRK10504 454166006279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006280 putative substrate translocation pore; other site 454166006281 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 454166006282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166006283 dimerization interface [polypeptide binding]; other site 454166006284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166006285 dimer interface [polypeptide binding]; other site 454166006286 phosphorylation site [posttranslational modification] 454166006287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166006288 ATP binding site [chemical binding]; other site 454166006289 Mg2+ binding site [ion binding]; other site 454166006290 G-X-G motif; other site 454166006291 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 454166006292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166006293 active site 454166006294 phosphorylation site [posttranslational modification] 454166006295 intermolecular recognition site; other site 454166006296 dimerization interface [polypeptide binding]; other site 454166006297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166006298 DNA binding site [nucleotide binding] 454166006299 PcfJ-like protein; Region: PcfJ; pfam14284 454166006300 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 454166006301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 454166006302 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 454166006303 putative protease; Provisional; Region: PRK15452 454166006304 Peptidase family U32; Region: Peptidase_U32; pfam01136 454166006305 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 454166006306 lipid kinase; Reviewed; Region: PRK13054 454166006307 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 454166006308 nucleoside transporter; Region: 2A0110; TIGR00889 454166006309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006310 putative substrate translocation pore; other site 454166006311 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 454166006312 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166006313 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 454166006314 substrate binding site [chemical binding]; other site 454166006315 ATP binding site [chemical binding]; other site 454166006316 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454166006317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166006318 DNA-binding site [nucleotide binding]; DNA binding site 454166006319 UTRA domain; Region: UTRA; pfam07702 454166006320 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 454166006321 dimer interface [polypeptide binding]; other site 454166006322 substrate binding site [chemical binding]; other site 454166006323 ATP binding site [chemical binding]; other site 454166006324 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 454166006325 substrate binding site [chemical binding]; other site 454166006326 multimerization interface [polypeptide binding]; other site 454166006327 ATP binding site [chemical binding]; other site 454166006328 Predicted integral membrane protein [Function unknown]; Region: COG5455 454166006329 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 454166006330 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 454166006331 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 454166006332 PapC N-terminal domain; Region: PapC_N; pfam13954 454166006333 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166006334 PapC C-terminal domain; Region: PapC_C; pfam13953 454166006335 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 454166006336 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166006337 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166006338 fimbrial chaperone protein; Provisional; Region: PRK15220 454166006339 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 454166006340 antiporter inner membrane protein; Provisional; Region: PRK11670 454166006341 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 454166006342 Walker A motif; other site 454166006343 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 454166006344 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 454166006345 active site 454166006346 HIGH motif; other site 454166006347 KMSKS motif; other site 454166006348 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 454166006349 tRNA binding surface [nucleotide binding]; other site 454166006350 anticodon binding site; other site 454166006351 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 454166006352 dimer interface [polypeptide binding]; other site 454166006353 putative tRNA-binding site [nucleotide binding]; other site 454166006354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 454166006355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 454166006356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 454166006357 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 454166006358 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 454166006359 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 454166006360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166006361 active site 454166006362 phosphorylation site [posttranslational modification] 454166006363 intermolecular recognition site; other site 454166006364 dimerization interface [polypeptide binding]; other site 454166006365 LytTr DNA-binding domain; Region: LytTR; pfam04397 454166006366 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 454166006367 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 454166006368 GAF domain; Region: GAF; pfam01590 454166006369 Histidine kinase; Region: His_kinase; pfam06580 454166006370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166006371 ATP binding site [chemical binding]; other site 454166006372 Mg2+ binding site [ion binding]; other site 454166006373 G-X-G motif; other site 454166006374 transcriptional regulator MirA; Provisional; Region: PRK15043 454166006375 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 454166006376 DNA binding residues [nucleotide binding] 454166006377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166006378 putative PBP binding loops; other site 454166006379 ABC-ATPase subunit interface; other site 454166006380 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 454166006381 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 454166006382 Walker A/P-loop; other site 454166006383 ATP binding site [chemical binding]; other site 454166006384 Q-loop/lid; other site 454166006385 ABC transporter signature motif; other site 454166006386 Walker B; other site 454166006387 D-loop; other site 454166006388 H-loop/switch region; other site 454166006389 CBS domain; Region: CBS; pfam00571 454166006390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166006391 dimer interface [polypeptide binding]; other site 454166006392 conserved gate region; other site 454166006393 ABC-ATPase subunit interface; other site 454166006394 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 454166006395 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 454166006396 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 454166006397 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 454166006398 D-lactate dehydrogenase; Provisional; Region: PRK11183 454166006399 FAD binding domain; Region: FAD_binding_4; pfam01565 454166006400 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 454166006401 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 454166006402 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 454166006403 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 454166006404 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454166006405 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 454166006406 oxidoreductase; Provisional; Region: PRK12743 454166006407 classical (c) SDRs; Region: SDR_c; cd05233 454166006408 NAD(P) binding site [chemical binding]; other site 454166006409 active site 454166006410 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 454166006411 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 454166006412 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 454166006413 FMN binding site [chemical binding]; other site 454166006414 active site 454166006415 catalytic residues [active] 454166006416 substrate binding site [chemical binding]; other site 454166006417 salicylate hydroxylase; Provisional; Region: PRK08163 454166006418 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 454166006419 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 454166006420 maleylacetoacetate isomerase; Region: maiA; TIGR01262 454166006421 C-terminal domain interface [polypeptide binding]; other site 454166006422 GSH binding site (G-site) [chemical binding]; other site 454166006423 putative dimer interface [polypeptide binding]; other site 454166006424 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 454166006425 dimer interface [polypeptide binding]; other site 454166006426 N-terminal domain interface [polypeptide binding]; other site 454166006427 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 454166006428 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 454166006429 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 454166006430 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 454166006431 Cupin domain; Region: Cupin_2; pfam07883 454166006432 Cupin domain; Region: Cupin_2; pfam07883 454166006433 benzoate transport; Region: 2A0115; TIGR00895 454166006434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006435 putative substrate translocation pore; other site 454166006436 hypothetical protein; Provisional; Region: PRK01821 454166006437 hypothetical protein; Provisional; Region: PRK10711 454166006438 cytidine deaminase; Provisional; Region: PRK09027 454166006439 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 454166006440 active site 454166006441 catalytic motif [active] 454166006442 Zn binding site [ion binding]; other site 454166006443 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 454166006444 active site 454166006445 catalytic motif [active] 454166006446 Zn binding site [ion binding]; other site 454166006447 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454166006448 putative active site [active] 454166006449 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 454166006450 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 454166006451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454166006452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166006453 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 454166006454 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 454166006455 homodimer interface [polypeptide binding]; other site 454166006456 active site 454166006457 FMN binding site [chemical binding]; other site 454166006458 substrate binding site [chemical binding]; other site 454166006459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454166006460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454166006461 TM-ABC transporter signature motif; other site 454166006462 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 454166006463 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 454166006464 Walker A/P-loop; other site 454166006465 ATP binding site [chemical binding]; other site 454166006466 Q-loop/lid; other site 454166006467 ABC transporter signature motif; other site 454166006468 Walker B; other site 454166006469 D-loop; other site 454166006470 H-loop/switch region; other site 454166006471 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 454166006472 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 454166006473 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 454166006474 ligand binding site [chemical binding]; other site 454166006475 calcium binding site [ion binding]; other site 454166006476 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 454166006477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166006478 DNA binding site [nucleotide binding] 454166006479 domain linker motif; other site 454166006480 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454166006481 dimerization interface (closed form) [polypeptide binding]; other site 454166006482 ligand binding site [chemical binding]; other site 454166006483 Predicted membrane protein [Function unknown]; Region: COG2311 454166006484 hypothetical protein; Provisional; Region: PRK10835 454166006485 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 454166006486 GTP cyclohydrolase I; Provisional; Region: PLN03044 454166006487 active site 454166006488 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 454166006489 S-formylglutathione hydrolase; Region: PLN02442 454166006490 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 454166006491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166006492 non-specific DNA binding site [nucleotide binding]; other site 454166006493 salt bridge; other site 454166006494 sequence-specific DNA binding site [nucleotide binding]; other site 454166006495 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 454166006496 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454166006497 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454166006498 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 454166006499 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 454166006500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166006501 motif II; other site 454166006502 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 454166006503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006504 putative substrate translocation pore; other site 454166006505 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 454166006506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166006507 N-terminal plug; other site 454166006508 ligand-binding site [chemical binding]; other site 454166006509 lysine transporter; Provisional; Region: PRK10836 454166006510 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 454166006511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166006512 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 454166006513 putative dimerization interface [polypeptide binding]; other site 454166006514 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 454166006515 endonuclease IV; Provisional; Region: PRK01060 454166006516 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 454166006517 AP (apurinic/apyrimidinic) site pocket; other site 454166006518 DNA interaction; other site 454166006519 Metal-binding active site; metal-binding site 454166006520 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 454166006521 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 454166006522 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 454166006523 active site 454166006524 P-loop; other site 454166006525 phosphorylation site [posttranslational modification] 454166006526 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 454166006527 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 454166006528 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 454166006529 putative substrate binding site [chemical binding]; other site 454166006530 putative ATP binding site [chemical binding]; other site 454166006531 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 454166006532 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166006533 active site 454166006534 phosphorylation site [posttranslational modification] 454166006535 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454166006536 dimerization domain swap beta strand [polypeptide binding]; other site 454166006537 regulatory protein interface [polypeptide binding]; other site 454166006538 active site 454166006539 regulatory phosphorylation site [posttranslational modification]; other site 454166006540 sugar efflux transporter B; Provisional; Region: PRK15011 454166006541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006542 putative substrate translocation pore; other site 454166006543 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 454166006544 Flagellin N-methylase; Region: FliB; cl00497 454166006545 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 454166006546 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 454166006547 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 454166006548 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454166006549 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 454166006550 active site 454166006551 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 454166006552 NlpC/P60 family; Region: NLPC_P60; pfam00877 454166006553 phage resistance protein; Provisional; Region: PRK10551 454166006554 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454166006555 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166006556 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 454166006557 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 454166006558 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 454166006559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166006560 dimer interface [polypeptide binding]; other site 454166006561 conserved gate region; other site 454166006562 putative PBP binding loops; other site 454166006563 ABC-ATPase subunit interface; other site 454166006564 microcin C ABC transporter permease; Provisional; Region: PRK15021 454166006565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166006566 dimer interface [polypeptide binding]; other site 454166006567 conserved gate region; other site 454166006568 ABC-ATPase subunit interface; other site 454166006569 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 454166006570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166006571 Walker A/P-loop; other site 454166006572 ATP binding site [chemical binding]; other site 454166006573 Q-loop/lid; other site 454166006574 ABC transporter signature motif; other site 454166006575 Walker B; other site 454166006576 D-loop; other site 454166006577 H-loop/switch region; other site 454166006578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 454166006579 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166006580 Walker A/P-loop; other site 454166006581 ATP binding site [chemical binding]; other site 454166006582 Q-loop/lid; other site 454166006583 ABC transporter signature motif; other site 454166006584 Walker B; other site 454166006585 D-loop; other site 454166006586 H-loop/switch region; other site 454166006587 hypothetical protein; Provisional; Region: PRK11835 454166006588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006589 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 454166006590 putative substrate translocation pore; other site 454166006591 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 454166006592 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166006593 RNA binding surface [nucleotide binding]; other site 454166006594 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 454166006595 active site 454166006596 uracil binding [chemical binding]; other site 454166006597 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 454166006598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166006599 ATP binding site [chemical binding]; other site 454166006600 putative Mg++ binding site [ion binding]; other site 454166006601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166006602 nucleotide binding region [chemical binding]; other site 454166006603 ATP-binding site [chemical binding]; other site 454166006604 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 454166006605 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 454166006606 5S rRNA interface [nucleotide binding]; other site 454166006607 CTC domain interface [polypeptide binding]; other site 454166006608 L16 interface [polypeptide binding]; other site 454166006609 Nucleoid-associated protein [General function prediction only]; Region: COG3081 454166006610 nucleoid-associated protein NdpA; Validated; Region: PRK00378 454166006611 hypothetical protein; Provisional; Region: PRK13689 454166006612 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 454166006613 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 454166006614 Sulfatase; Region: Sulfatase; cl17466 454166006615 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 454166006616 transcriptional regulator NarP; Provisional; Region: PRK10403 454166006617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166006618 active site 454166006619 phosphorylation site [posttranslational modification] 454166006620 intermolecular recognition site; other site 454166006621 dimerization interface [polypeptide binding]; other site 454166006622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166006623 DNA binding residues [nucleotide binding] 454166006624 dimerization interface [polypeptide binding]; other site 454166006625 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 454166006626 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 454166006627 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 454166006628 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 454166006629 catalytic residues [active] 454166006630 central insert; other site 454166006631 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 454166006632 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 454166006633 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 454166006634 heme exporter protein CcmC; Region: ccmC; TIGR01191 454166006635 heme exporter protein CcmB; Region: ccmB; TIGR01190 454166006636 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 454166006637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166006638 Walker A/P-loop; other site 454166006639 ATP binding site [chemical binding]; other site 454166006640 Q-loop/lid; other site 454166006641 ABC transporter signature motif; other site 454166006642 Walker B; other site 454166006643 D-loop; other site 454166006644 H-loop/switch region; other site 454166006645 cytochrome c-type protein NapC; Provisional; Region: PRK10617 454166006646 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 454166006647 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 454166006648 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 454166006649 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 454166006650 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 454166006651 [4Fe-4S] binding site [ion binding]; other site 454166006652 molybdopterin cofactor binding site; other site 454166006653 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 454166006654 molybdopterin cofactor binding site; other site 454166006655 ferredoxin-type protein; Provisional; Region: PRK10194 454166006656 4Fe-4S binding domain; Region: Fer4; cl02805 454166006657 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 454166006658 secondary substrate binding site; other site 454166006659 primary substrate binding site; other site 454166006660 inhibition loop; other site 454166006661 dimerization interface [polypeptide binding]; other site 454166006662 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 454166006663 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 454166006664 Walker A/P-loop; other site 454166006665 ATP binding site [chemical binding]; other site 454166006666 Q-loop/lid; other site 454166006667 ABC transporter signature motif; other site 454166006668 Walker B; other site 454166006669 D-loop; other site 454166006670 H-loop/switch region; other site 454166006671 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 454166006672 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 454166006673 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 454166006674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166006675 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 454166006676 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 454166006677 DNA binding site [nucleotide binding] 454166006678 active site 454166006679 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 454166006680 ApbE family; Region: ApbE; pfam02424 454166006681 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 454166006682 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 454166006683 trimer interface [polypeptide binding]; other site 454166006684 eyelet of channel; other site 454166006685 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 454166006686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166006687 ATP binding site [chemical binding]; other site 454166006688 G-X-G motif; other site 454166006689 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454166006690 putative binding surface; other site 454166006691 active site 454166006692 transcriptional regulator RcsB; Provisional; Region: PRK10840 454166006693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166006694 active site 454166006695 phosphorylation site [posttranslational modification] 454166006696 intermolecular recognition site; other site 454166006697 dimerization interface [polypeptide binding]; other site 454166006698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166006699 DNA binding residues [nucleotide binding] 454166006700 dimerization interface [polypeptide binding]; other site 454166006701 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 454166006702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166006703 dimer interface [polypeptide binding]; other site 454166006704 phosphorylation site [posttranslational modification] 454166006705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166006706 ATP binding site [chemical binding]; other site 454166006707 Mg2+ binding site [ion binding]; other site 454166006708 G-X-G motif; other site 454166006709 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 454166006710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166006711 active site 454166006712 phosphorylation site [posttranslational modification] 454166006713 intermolecular recognition site; other site 454166006714 dimerization interface [polypeptide binding]; other site 454166006715 DNA gyrase subunit A; Validated; Region: PRK05560 454166006716 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 454166006717 CAP-like domain; other site 454166006718 active site 454166006719 primary dimer interface [polypeptide binding]; other site 454166006720 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454166006721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454166006722 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454166006723 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454166006724 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454166006725 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454166006726 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 454166006727 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 454166006728 active site pocket [active] 454166006729 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 454166006730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006731 putative substrate translocation pore; other site 454166006732 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454166006733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166006734 DNA-binding site [nucleotide binding]; DNA binding site 454166006735 FCD domain; Region: FCD; pfam07729 454166006736 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 454166006737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166006738 S-adenosylmethionine binding site [chemical binding]; other site 454166006739 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 454166006740 ATP cone domain; Region: ATP-cone; pfam03477 454166006741 Class I ribonucleotide reductase; Region: RNR_I; cd01679 454166006742 active site 454166006743 dimer interface [polypeptide binding]; other site 454166006744 catalytic residues [active] 454166006745 effector binding site; other site 454166006746 R2 peptide binding site; other site 454166006747 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 454166006748 dimer interface [polypeptide binding]; other site 454166006749 putative radical transfer pathway; other site 454166006750 diiron center [ion binding]; other site 454166006751 tyrosyl radical; other site 454166006752 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 454166006753 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454166006754 catalytic loop [active] 454166006755 iron binding site [ion binding]; other site 454166006756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166006757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006758 putative substrate translocation pore; other site 454166006759 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 454166006760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166006761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166006762 dimerization interface [polypeptide binding]; other site 454166006763 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 454166006764 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 454166006765 active site 454166006766 catalytic site [active] 454166006767 metal binding site [ion binding]; metal-binding site 454166006768 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 454166006769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006770 putative substrate translocation pore; other site 454166006771 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 454166006772 hydroxyglutarate oxidase; Provisional; Region: PRK11728 454166006773 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 454166006774 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 454166006775 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 454166006776 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 454166006777 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454166006778 Cysteine-rich domain; Region: CCG; pfam02754 454166006779 Cysteine-rich domain; Region: CCG; pfam02754 454166006780 deubiquitinase SseL; Provisional; Region: PRK14848 454166006781 Competence-damaged protein; Region: CinA; cl00666 454166006782 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 454166006783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166006784 D-galactonate transporter; Region: 2A0114; TIGR00893 454166006785 putative substrate translocation pore; other site 454166006786 L-rhamnonate dehydratase; Provisional; Region: PRK15440 454166006787 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 454166006788 putative active site pocket [active] 454166006789 putative metal binding site [ion binding]; other site 454166006790 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454166006791 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454166006792 Bacterial transcriptional regulator; Region: IclR; pfam01614 454166006793 hypothetical protein; Provisional; Region: PRK03673 454166006794 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 454166006795 putative MPT binding site; other site 454166006796 Competence-damaged protein; Region: CinA; cl00666 454166006797 YfaZ precursor; Region: YfaZ; pfam07437 454166006798 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 454166006799 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 454166006800 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 454166006801 catalytic core [active] 454166006802 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 454166006803 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 454166006804 inhibitor-cofactor binding pocket; inhibition site 454166006805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166006806 catalytic residue [active] 454166006807 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 454166006808 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 454166006809 Ligand binding site; other site 454166006810 Putative Catalytic site; other site 454166006811 DXD motif; other site 454166006812 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 454166006813 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 454166006814 active site 454166006815 substrate binding site [chemical binding]; other site 454166006816 cosubstrate binding site; other site 454166006817 catalytic site [active] 454166006818 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 454166006819 active site 454166006820 hexamer interface [polypeptide binding]; other site 454166006821 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 454166006822 NAD binding site [chemical binding]; other site 454166006823 substrate binding site [chemical binding]; other site 454166006824 active site 454166006825 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 454166006826 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 454166006827 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 454166006828 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 454166006829 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 454166006830 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 454166006831 signal transduction protein PmrD; Provisional; Region: PRK15450 454166006832 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 454166006833 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 454166006834 acyl-activating enzyme (AAE) consensus motif; other site 454166006835 putative AMP binding site [chemical binding]; other site 454166006836 putative active site [active] 454166006837 putative CoA binding site [chemical binding]; other site 454166006838 O-succinylbenzoate synthase; Provisional; Region: PRK05105 454166006839 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 454166006840 active site 454166006841 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454166006842 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 454166006843 substrate binding site [chemical binding]; other site 454166006844 oxyanion hole (OAH) forming residues; other site 454166006845 trimer interface [polypeptide binding]; other site 454166006846 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 454166006847 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 454166006848 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 454166006849 dimer interface [polypeptide binding]; other site 454166006850 tetramer interface [polypeptide binding]; other site 454166006851 PYR/PP interface [polypeptide binding]; other site 454166006852 TPP binding site [chemical binding]; other site 454166006853 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 454166006854 TPP-binding site; other site 454166006855 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 454166006856 isochorismate synthases; Region: isochor_syn; TIGR00543 454166006857 hypothetical protein; Provisional; Region: PRK10404 454166006858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166006859 Coenzyme A binding pocket [chemical binding]; other site 454166006860 ribonuclease BN; Region: true_RNase_BN; TIGR02649 454166006861 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 454166006862 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 454166006863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166006864 active site 454166006865 phosphorylation site [posttranslational modification] 454166006866 intermolecular recognition site; other site 454166006867 dimerization interface [polypeptide binding]; other site 454166006868 von Willebrand factor; Region: vWF_A; pfam12450 454166006869 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 454166006870 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 454166006871 metal ion-dependent adhesion site (MIDAS); other site 454166006872 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 454166006873 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 454166006874 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 454166006875 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006876 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006877 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006878 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006879 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006880 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006881 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006882 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006883 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006884 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006885 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006886 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006887 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006888 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006889 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166006890 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 454166006891 Autotransporter beta-domain; Region: Autotransporter; smart00869 454166006892 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 454166006893 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454166006894 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 454166006895 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454166006896 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 454166006897 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 454166006898 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454166006899 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 454166006900 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 454166006901 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 454166006902 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 454166006903 4Fe-4S binding domain; Region: Fer4; pfam00037 454166006904 4Fe-4S binding domain; Region: Fer4; pfam00037 454166006905 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 454166006906 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 454166006907 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454166006908 catalytic loop [active] 454166006909 iron binding site [ion binding]; other site 454166006910 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 454166006911 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 454166006912 [4Fe-4S] binding site [ion binding]; other site 454166006913 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 454166006914 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 454166006915 SLBB domain; Region: SLBB; pfam10531 454166006916 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 454166006917 NADH dehydrogenase subunit E; Validated; Region: PRK07539 454166006918 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 454166006919 putative dimer interface [polypeptide binding]; other site 454166006920 [2Fe-2S] cluster binding site [ion binding]; other site 454166006921 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 454166006922 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 454166006923 NADH dehydrogenase subunit D; Validated; Region: PRK06075 454166006924 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 454166006925 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 454166006926 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 454166006927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166006928 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 454166006929 putative dimerization interface [polypeptide binding]; other site 454166006930 aminotransferase AlaT; Validated; Region: PRK09265 454166006931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166006932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166006933 homodimer interface [polypeptide binding]; other site 454166006934 catalytic residue [active] 454166006935 5'-nucleotidase; Provisional; Region: PRK03826 454166006936 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454166006937 transmembrane helices; other site 454166006938 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 454166006939 TrkA-C domain; Region: TrkA_C; pfam02080 454166006940 TrkA-C domain; Region: TrkA_C; pfam02080 454166006941 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454166006942 putative phosphatase; Provisional; Region: PRK11587 454166006943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166006944 motif II; other site 454166006945 hypothetical protein; Validated; Region: PRK05445 454166006946 hypothetical protein; Provisional; Region: PRK01816 454166006947 propionate/acetate kinase; Provisional; Region: PRK12379 454166006948 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 454166006949 phosphate acetyltransferase; Reviewed; Region: PRK05632 454166006950 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 454166006951 DRTGG domain; Region: DRTGG; pfam07085 454166006952 phosphate acetyltransferase; Region: pta; TIGR00651 454166006953 hypothetical protein; Provisional; Region: PRK11588 454166006954 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 454166006955 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 454166006956 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454166006957 PYR/PP interface [polypeptide binding]; other site 454166006958 dimer interface [polypeptide binding]; other site 454166006959 TPP binding site [chemical binding]; other site 454166006960 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454166006961 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 454166006962 TPP-binding site [chemical binding]; other site 454166006963 dimer interface [polypeptide binding]; other site 454166006964 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 454166006965 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 454166006966 active site 454166006967 P-loop; other site 454166006968 phosphorylation site [posttranslational modification] 454166006969 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166006970 active site 454166006971 phosphorylation site [posttranslational modification] 454166006972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454166006973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166006974 DNA binding site [nucleotide binding] 454166006975 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454166006976 putative dimerization interface [polypeptide binding]; other site 454166006977 putative ligand binding site [chemical binding]; other site 454166006978 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 454166006979 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 454166006980 nudix motif; other site 454166006981 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 454166006982 active site 454166006983 metal binding site [ion binding]; metal-binding site 454166006984 homotetramer interface [polypeptide binding]; other site 454166006985 glutathione S-transferase; Provisional; Region: PRK15113 454166006986 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 454166006987 C-terminal domain interface [polypeptide binding]; other site 454166006988 GSH binding site (G-site) [chemical binding]; other site 454166006989 dimer interface [polypeptide binding]; other site 454166006990 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 454166006991 N-terminal domain interface [polypeptide binding]; other site 454166006992 putative dimer interface [polypeptide binding]; other site 454166006993 putative substrate binding pocket (H-site) [chemical binding]; other site 454166006994 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 454166006995 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 454166006996 C-terminal domain interface [polypeptide binding]; other site 454166006997 GSH binding site (G-site) [chemical binding]; other site 454166006998 dimer interface [polypeptide binding]; other site 454166006999 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 454166007000 N-terminal domain interface [polypeptide binding]; other site 454166007001 putative dimer interface [polypeptide binding]; other site 454166007002 active site 454166007003 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 454166007004 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 454166007005 putative NAD(P) binding site [chemical binding]; other site 454166007006 putative active site [active] 454166007007 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 454166007008 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 454166007009 Walker A/P-loop; other site 454166007010 ATP binding site [chemical binding]; other site 454166007011 Q-loop/lid; other site 454166007012 ABC transporter signature motif; other site 454166007013 Walker B; other site 454166007014 D-loop; other site 454166007015 H-loop/switch region; other site 454166007016 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166007017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166007018 dimer interface [polypeptide binding]; other site 454166007019 conserved gate region; other site 454166007020 putative PBP binding loops; other site 454166007021 ABC-ATPase subunit interface; other site 454166007022 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 454166007023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166007024 dimer interface [polypeptide binding]; other site 454166007025 conserved gate region; other site 454166007026 putative PBP binding loops; other site 454166007027 ABC-ATPase subunit interface; other site 454166007028 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 454166007029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166007030 substrate binding pocket [chemical binding]; other site 454166007031 membrane-bound complex binding site; other site 454166007032 hinge residues; other site 454166007033 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 454166007034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166007035 substrate binding pocket [chemical binding]; other site 454166007036 membrane-bound complex binding site; other site 454166007037 hinge residues; other site 454166007038 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 454166007039 Flavoprotein; Region: Flavoprotein; pfam02441 454166007040 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 454166007041 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 454166007042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 454166007043 dimer interface [polypeptide binding]; other site 454166007044 active site 454166007045 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454166007046 substrate binding site [chemical binding]; other site 454166007047 catalytic residue [active] 454166007048 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 454166007049 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 454166007050 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 454166007051 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454166007052 catalytic residue [active] 454166007053 PAS fold; Region: PAS_4; pfam08448 454166007054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 454166007055 putative active site [active] 454166007056 heme pocket [chemical binding]; other site 454166007057 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 454166007058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166007059 Walker A motif; other site 454166007060 ATP binding site [chemical binding]; other site 454166007061 Walker B motif; other site 454166007062 arginine finger; other site 454166007063 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454166007064 amidophosphoribosyltransferase; Provisional; Region: PRK09246 454166007065 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 454166007066 active site 454166007067 tetramer interface [polypeptide binding]; other site 454166007068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166007069 active site 454166007070 colicin V production protein; Provisional; Region: PRK10845 454166007071 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 454166007072 cell division protein DedD; Provisional; Region: PRK11633 454166007073 Sporulation related domain; Region: SPOR; pfam05036 454166007074 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 454166007075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454166007076 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454166007077 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 454166007078 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 454166007079 hypothetical protein; Provisional; Region: PRK10847 454166007080 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454166007081 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 454166007082 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 454166007083 dimerization interface 3.5A [polypeptide binding]; other site 454166007084 active site 454166007085 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 454166007086 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 454166007087 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 454166007088 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 454166007089 ligand binding site [chemical binding]; other site 454166007090 NAD binding site [chemical binding]; other site 454166007091 catalytic site [active] 454166007092 homodimer interface [polypeptide binding]; other site 454166007093 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 454166007094 putative transporter; Provisional; Region: PRK12382 454166007095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007096 putative substrate translocation pore; other site 454166007097 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 454166007098 CAAX protease self-immunity; Region: Abi; pfam02517 454166007099 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 454166007100 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 454166007101 dimer interface [polypeptide binding]; other site 454166007102 active site 454166007103 Uncharacterized conserved protein [Function unknown]; Region: COG4121 454166007104 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 454166007105 YfcL protein; Region: YfcL; pfam08891 454166007106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 454166007107 hypothetical protein; Provisional; Region: PRK10621 454166007108 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 454166007109 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 454166007110 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 454166007111 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 454166007112 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 454166007113 Tetramer interface [polypeptide binding]; other site 454166007114 active site 454166007115 FMN-binding site [chemical binding]; other site 454166007116 hypothetical protein; Provisional; Region: PRK04946 454166007117 Smr domain; Region: Smr; pfam01713 454166007118 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454166007119 catalytic core [active] 454166007120 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 454166007121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454166007122 substrate binding site [chemical binding]; other site 454166007123 oxyanion hole (OAH) forming residues; other site 454166007124 trimer interface [polypeptide binding]; other site 454166007125 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 454166007126 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 454166007127 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 454166007128 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 454166007129 dimer interface [polypeptide binding]; other site 454166007130 active site 454166007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 454166007132 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 454166007133 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 454166007134 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 454166007135 outer membrane protease; Reviewed; Region: PRK10993 454166007136 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 454166007137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166007138 active site 454166007139 phosphorylation site [posttranslational modification] 454166007140 intermolecular recognition site; other site 454166007141 dimerization interface [polypeptide binding]; other site 454166007142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 454166007143 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454166007144 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 454166007145 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 454166007146 dimerization interface [polypeptide binding]; other site 454166007147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166007148 dimer interface [polypeptide binding]; other site 454166007149 phosphorylation site [posttranslational modification] 454166007150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166007151 ATP binding site [chemical binding]; other site 454166007152 Mg2+ binding site [ion binding]; other site 454166007153 G-X-G motif; other site 454166007154 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 454166007155 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454166007156 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 454166007157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007159 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 454166007160 aminotransferase; Validated; Region: PRK08175 454166007161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166007162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166007163 homodimer interface [polypeptide binding]; other site 454166007164 catalytic residue [active] 454166007165 glucokinase; Provisional; Region: glk; PRK00292 454166007166 glucokinase, proteobacterial type; Region: glk; TIGR00749 454166007167 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 454166007168 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 454166007169 Cl- selectivity filter; other site 454166007170 Cl- binding residues [ion binding]; other site 454166007171 pore gating glutamate residue; other site 454166007172 dimer interface [polypeptide binding]; other site 454166007173 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 454166007174 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 454166007175 dimer interface [polypeptide binding]; other site 454166007176 PYR/PP interface [polypeptide binding]; other site 454166007177 TPP binding site [chemical binding]; other site 454166007178 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454166007179 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 454166007180 TPP-binding site [chemical binding]; other site 454166007181 dimer interface [polypeptide binding]; other site 454166007182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166007183 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166007184 active site 454166007185 catalytic tetrad [active] 454166007186 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 454166007187 manganese transport protein MntH; Reviewed; Region: PRK00701 454166007188 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 454166007189 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 454166007190 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 454166007191 Nucleoside recognition; Region: Gate; pfam07670 454166007192 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 454166007193 MASE1; Region: MASE1; pfam05231 454166007194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454166007195 diguanylate cyclase; Region: GGDEF; smart00267 454166007196 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166007197 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 454166007198 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 454166007199 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 454166007200 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 454166007201 active site 454166007202 HIGH motif; other site 454166007203 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 454166007204 active site 454166007205 KMSKS motif; other site 454166007206 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 454166007207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166007208 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 454166007209 putative dimerization interface [polypeptide binding]; other site 454166007210 putative substrate binding pocket [chemical binding]; other site 454166007211 XapX domain; Region: XapX; TIGR03510 454166007212 nucleoside transporter; Region: 2A0110; TIGR00889 454166007213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007214 putative substrate translocation pore; other site 454166007215 purine nucleoside phosphorylase; Provisional; Region: PRK08202 454166007216 hypothetical protein; Provisional; Region: PRK11528 454166007217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166007218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166007219 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 454166007220 putative dimerization interface [polypeptide binding]; other site 454166007221 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 454166007222 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 454166007223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 454166007224 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 454166007225 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 454166007226 nucleotide binding pocket [chemical binding]; other site 454166007227 K-X-D-G motif; other site 454166007228 catalytic site [active] 454166007229 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 454166007230 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 454166007231 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 454166007232 Dimer interface [polypeptide binding]; other site 454166007233 BRCT sequence motif; other site 454166007234 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 454166007235 cell division protein ZipA; Provisional; Region: PRK03427 454166007236 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 454166007237 FtsZ protein binding site [polypeptide binding]; other site 454166007238 putative sulfate transport protein CysZ; Validated; Region: PRK04949 454166007239 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 454166007240 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 454166007241 dimer interface [polypeptide binding]; other site 454166007242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166007243 catalytic residue [active] 454166007244 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454166007245 dimerization domain swap beta strand [polypeptide binding]; other site 454166007246 regulatory protein interface [polypeptide binding]; other site 454166007247 active site 454166007248 regulatory phosphorylation site [posttranslational modification]; other site 454166007249 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 454166007250 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 454166007251 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 454166007252 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 454166007253 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 454166007254 HPr interaction site; other site 454166007255 glycerol kinase (GK) interaction site [polypeptide binding]; other site 454166007256 active site 454166007257 phosphorylation site [posttranslational modification] 454166007258 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 454166007259 dimer interface [polypeptide binding]; other site 454166007260 pyridoxamine kinase; Validated; Region: PRK05756 454166007261 pyridoxal binding site [chemical binding]; other site 454166007262 ATP binding site [chemical binding]; other site 454166007263 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 454166007264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166007265 DNA-binding site [nucleotide binding]; DNA binding site 454166007266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166007267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166007268 homodimer interface [polypeptide binding]; other site 454166007269 catalytic residue [active] 454166007270 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 454166007271 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 454166007272 catalytic triad [active] 454166007273 hypothetical protein; Provisional; Region: PRK10318 454166007274 Transglycosylase; Region: Transgly; cl17702 454166007275 cysteine synthase B; Region: cysM; TIGR01138 454166007276 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 454166007277 dimer interface [polypeptide binding]; other site 454166007278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166007279 catalytic residue [active] 454166007280 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 454166007281 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 454166007282 Walker A/P-loop; other site 454166007283 ATP binding site [chemical binding]; other site 454166007284 Q-loop/lid; other site 454166007285 ABC transporter signature motif; other site 454166007286 Walker B; other site 454166007287 D-loop; other site 454166007288 H-loop/switch region; other site 454166007289 TOBE-like domain; Region: TOBE_3; pfam12857 454166007290 sulfate transport protein; Provisional; Region: cysT; CHL00187 454166007291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166007292 dimer interface [polypeptide binding]; other site 454166007293 conserved gate region; other site 454166007294 putative PBP binding loops; other site 454166007295 ABC-ATPase subunit interface; other site 454166007296 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 454166007297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166007298 dimer interface [polypeptide binding]; other site 454166007299 conserved gate region; other site 454166007300 putative PBP binding loops; other site 454166007301 ABC-ATPase subunit interface; other site 454166007302 thiosulfate transporter subunit; Provisional; Region: PRK10852 454166007303 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454166007304 short chain dehydrogenase; Provisional; Region: PRK08226 454166007305 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 454166007306 NAD binding site [chemical binding]; other site 454166007307 homotetramer interface [polypeptide binding]; other site 454166007308 homodimer interface [polypeptide binding]; other site 454166007309 active site 454166007310 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 454166007311 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 454166007312 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 454166007313 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 454166007314 putative acetyltransferase; Provisional; Region: PRK03624 454166007315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166007316 Coenzyme A binding pocket [chemical binding]; other site 454166007317 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 454166007318 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 454166007319 active site 454166007320 metal binding site [ion binding]; metal-binding site 454166007321 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 454166007322 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 454166007323 transcriptional regulator EutR; Provisional; Region: PRK10130 454166007324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166007325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166007326 carboxysome structural protein EutK; Provisional; Region: PRK15466 454166007327 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 454166007328 Hexamer interface [polypeptide binding]; other site 454166007329 Hexagonal pore residue; other site 454166007330 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 454166007331 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 454166007332 putative hexamer interface [polypeptide binding]; other site 454166007333 putative hexagonal pore; other site 454166007334 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 454166007335 putative hexamer interface [polypeptide binding]; other site 454166007336 putative hexagonal pore; other site 454166007337 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 454166007338 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 454166007339 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 454166007340 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 454166007341 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 454166007342 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 454166007343 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 454166007344 active site 454166007345 metal binding site [ion binding]; metal-binding site 454166007346 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 454166007347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166007348 nucleotide binding site [chemical binding]; other site 454166007349 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 454166007350 putative catalytic cysteine [active] 454166007351 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 454166007352 Hexamer/Pentamer interface [polypeptide binding]; other site 454166007353 central pore; other site 454166007354 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 454166007355 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 454166007356 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 454166007357 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 454166007358 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 454166007359 G1 box; other site 454166007360 GTP/Mg2+ binding site [chemical binding]; other site 454166007361 G2 box; other site 454166007362 Switch I region; other site 454166007363 G3 box; other site 454166007364 Switch II region; other site 454166007365 G4 box; other site 454166007366 G5 box; other site 454166007367 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 454166007368 putative hexamer interface [polypeptide binding]; other site 454166007369 putative hexagonal pore; other site 454166007370 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 454166007371 Malic enzyme, N-terminal domain; Region: malic; pfam00390 454166007372 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 454166007373 putative NAD(P) binding site [chemical binding]; other site 454166007374 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 454166007375 transaldolase-like protein; Provisional; Region: PTZ00411 454166007376 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 454166007377 active site 454166007378 dimer interface [polypeptide binding]; other site 454166007379 catalytic residue [active] 454166007380 transketolase; Reviewed; Region: PRK12753 454166007381 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 454166007382 TPP-binding site [chemical binding]; other site 454166007383 dimer interface [polypeptide binding]; other site 454166007384 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454166007385 PYR/PP interface [polypeptide binding]; other site 454166007386 dimer interface [polypeptide binding]; other site 454166007387 TPP binding site [chemical binding]; other site 454166007388 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454166007389 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 454166007390 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 454166007391 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 454166007392 dimer interface [polypeptide binding]; other site 454166007393 ADP-ribose binding site [chemical binding]; other site 454166007394 active site 454166007395 nudix motif; other site 454166007396 metal binding site [ion binding]; metal-binding site 454166007397 putative periplasmic esterase; Provisional; Region: PRK03642 454166007398 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 454166007399 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 454166007400 4Fe-4S binding domain; Region: Fer4; pfam00037 454166007401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 454166007402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166007403 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 454166007404 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 454166007405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166007406 dimerization interface [polypeptide binding]; other site 454166007407 Histidine kinase; Region: HisKA_3; pfam07730 454166007408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166007409 ATP binding site [chemical binding]; other site 454166007410 Mg2+ binding site [ion binding]; other site 454166007411 G-X-G motif; other site 454166007412 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 454166007413 Protein export membrane protein; Region: SecD_SecF; cl14618 454166007414 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 454166007415 ArsC family; Region: ArsC; pfam03960 454166007416 putative catalytic residues [active] 454166007417 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 454166007418 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 454166007419 metal binding site [ion binding]; metal-binding site 454166007420 dimer interface [polypeptide binding]; other site 454166007421 hypothetical protein; Provisional; Region: PRK13664 454166007422 Predicted metalloprotease [General function prediction only]; Region: COG2321 454166007423 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 454166007424 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 454166007425 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 454166007426 ATP binding site [chemical binding]; other site 454166007427 active site 454166007428 substrate binding site [chemical binding]; other site 454166007429 lipoprotein; Provisional; Region: PRK11679 454166007430 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 454166007431 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 454166007432 dihydrodipicolinate synthase; Region: dapA; TIGR00674 454166007433 dimer interface [polypeptide binding]; other site 454166007434 active site 454166007435 catalytic residue [active] 454166007436 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 454166007437 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 454166007438 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 454166007439 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 454166007440 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 454166007441 catalytic triad [active] 454166007442 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 454166007443 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 454166007444 fructuronate transporter; Provisional; Region: PRK10034; cl15264 454166007445 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 454166007446 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 454166007447 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 454166007448 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 454166007449 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454166007450 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 454166007451 Peptidase family M48; Region: Peptidase_M48; cl12018 454166007452 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 454166007453 ArsC family; Region: ArsC; pfam03960 454166007454 catalytic residues [active] 454166007455 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 454166007456 DNA replication initiation factor; Provisional; Region: PRK08084 454166007457 uracil transporter; Provisional; Region: PRK10720 454166007458 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166007459 active site 454166007460 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 454166007461 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 454166007462 dimerization interface [polypeptide binding]; other site 454166007463 putative ATP binding site [chemical binding]; other site 454166007464 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 454166007465 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 454166007466 active site 454166007467 substrate binding site [chemical binding]; other site 454166007468 cosubstrate binding site; other site 454166007469 catalytic site [active] 454166007470 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 454166007471 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 454166007472 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 454166007473 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 454166007474 putative active site [active] 454166007475 catalytic site [active] 454166007476 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 454166007477 domain interface [polypeptide binding]; other site 454166007478 active site 454166007479 catalytic site [active] 454166007480 exopolyphosphatase; Provisional; Region: PRK10854 454166007481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166007482 nucleotide binding site [chemical binding]; other site 454166007483 MASE1; Region: MASE1; pfam05231 454166007484 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454166007485 diguanylate cyclase; Region: GGDEF; smart00267 454166007486 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166007487 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 454166007488 Integrase core domain; Region: rve; pfam00665 454166007489 SEC-C motif; Region: SEC-C; pfam02810 454166007490 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 454166007491 GMP synthase; Reviewed; Region: guaA; PRK00074 454166007492 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 454166007493 AMP/PPi binding site [chemical binding]; other site 454166007494 candidate oxyanion hole; other site 454166007495 catalytic triad [active] 454166007496 potential glutamine specificity residues [chemical binding]; other site 454166007497 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 454166007498 ATP Binding subdomain [chemical binding]; other site 454166007499 Ligand Binding sites [chemical binding]; other site 454166007500 Dimerization subdomain; other site 454166007501 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 454166007502 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 454166007503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 454166007504 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 454166007505 active site 454166007506 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 454166007507 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 454166007508 generic binding surface II; other site 454166007509 generic binding surface I; other site 454166007510 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 454166007511 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 454166007512 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166007513 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166007514 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166007515 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166007516 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 454166007517 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 454166007518 Autotransporter beta-domain; Region: Autotransporter; smart00869 454166007519 outer membrane protein RatA; Provisional; Region: PRK15315 454166007520 Oxygen tolerance; Region: BatD; pfam13584 454166007521 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454166007522 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454166007523 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454166007524 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454166007525 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454166007526 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454166007527 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454166007528 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454166007529 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454166007530 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 454166007531 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 454166007532 intimin-like protein SinH; Provisional; Region: PRK15318 454166007533 intimin-like protein SinH; Provisional; Region: PRK15318 454166007534 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 454166007535 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 454166007536 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 454166007537 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 454166007538 Trp docking motif [polypeptide binding]; other site 454166007539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 454166007540 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 454166007541 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 454166007542 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 454166007543 dimer interface [polypeptide binding]; other site 454166007544 motif 1; other site 454166007545 active site 454166007546 motif 2; other site 454166007547 motif 3; other site 454166007548 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 454166007549 anticodon binding site; other site 454166007550 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 454166007551 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 454166007552 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 454166007553 cytoskeletal protein RodZ; Provisional; Region: PRK10856 454166007554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166007555 non-specific DNA binding site [nucleotide binding]; other site 454166007556 salt bridge; other site 454166007557 sequence-specific DNA binding site [nucleotide binding]; other site 454166007558 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 454166007559 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 454166007560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166007561 FeS/SAM binding site; other site 454166007562 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 454166007563 active site 454166007564 multimer interface [polypeptide binding]; other site 454166007565 4Fe-4S binding domain; Region: Fer4; pfam00037 454166007566 hydrogenase 4 subunit H; Validated; Region: PRK08222 454166007567 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 454166007568 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454166007569 4Fe-4S binding domain; Region: Fer4; pfam00037 454166007570 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454166007571 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454166007572 putative [Fe4-S4] binding site [ion binding]; other site 454166007573 putative molybdopterin cofactor binding site [chemical binding]; other site 454166007574 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454166007575 putative molybdopterin cofactor binding site; other site 454166007576 penicillin-binding protein 1C; Provisional; Region: PRK11240 454166007577 Transglycosylase; Region: Transgly; pfam00912 454166007578 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 454166007579 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 454166007580 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 454166007581 MG2 domain; Region: A2M_N; pfam01835 454166007582 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 454166007583 surface patch; other site 454166007584 thioester region; other site 454166007585 specificity defining residues; other site 454166007586 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 454166007587 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 454166007588 active site residue [active] 454166007589 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 454166007590 active site residue [active] 454166007591 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 454166007592 aminopeptidase B; Provisional; Region: PRK05015 454166007593 Peptidase; Region: DUF3663; pfam12404 454166007594 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 454166007595 interface (dimer of trimers) [polypeptide binding]; other site 454166007596 Substrate-binding/catalytic site; other site 454166007597 Zn-binding sites [ion binding]; other site 454166007598 hypothetical protein; Provisional; Region: PRK10721 454166007599 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 454166007600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 454166007601 catalytic loop [active] 454166007602 iron binding site [ion binding]; other site 454166007603 chaperone protein HscA; Provisional; Region: hscA; PRK05183 454166007604 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 454166007605 nucleotide binding site [chemical binding]; other site 454166007606 putative NEF/HSP70 interaction site [polypeptide binding]; other site 454166007607 SBD interface [polypeptide binding]; other site 454166007608 co-chaperone HscB; Provisional; Region: hscB; PRK05014 454166007609 DnaJ domain; Region: DnaJ; pfam00226 454166007610 HSP70 interaction site [polypeptide binding]; other site 454166007611 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 454166007612 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 454166007613 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 454166007614 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 454166007615 trimerization site [polypeptide binding]; other site 454166007616 active site 454166007617 cysteine desulfurase; Provisional; Region: PRK14012 454166007618 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 454166007619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166007620 catalytic residue [active] 454166007621 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 454166007622 Rrf2 family protein; Region: rrf2_super; TIGR00738 454166007623 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 454166007624 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 454166007625 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 454166007626 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 454166007627 active site 454166007628 dimerization interface [polypeptide binding]; other site 454166007629 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 454166007630 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 454166007631 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 454166007632 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454166007633 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 454166007634 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 454166007635 FAD binding pocket [chemical binding]; other site 454166007636 FAD binding motif [chemical binding]; other site 454166007637 phosphate binding motif [ion binding]; other site 454166007638 beta-alpha-beta structure motif; other site 454166007639 NAD binding pocket [chemical binding]; other site 454166007640 Iron coordination center [ion binding]; other site 454166007641 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 454166007642 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454166007643 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454166007644 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 454166007645 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 454166007646 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 454166007647 PRD domain; Region: PRD; pfam00874 454166007648 PRD domain; Region: PRD; pfam00874 454166007649 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 454166007650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007651 putative substrate translocation pore; other site 454166007652 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 454166007653 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 454166007654 dimer interface [polypeptide binding]; other site 454166007655 active site 454166007656 glycine-pyridoxal phosphate binding site [chemical binding]; other site 454166007657 folate binding site [chemical binding]; other site 454166007658 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 454166007659 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 454166007660 heme-binding site [chemical binding]; other site 454166007661 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 454166007662 FAD binding pocket [chemical binding]; other site 454166007663 FAD binding motif [chemical binding]; other site 454166007664 phosphate binding motif [ion binding]; other site 454166007665 beta-alpha-beta structure motif; other site 454166007666 NAD binding pocket [chemical binding]; other site 454166007667 Heme binding pocket [chemical binding]; other site 454166007668 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 454166007669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166007670 DNA binding site [nucleotide binding] 454166007671 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454166007672 TPR repeat; Region: TPR_11; pfam13414 454166007673 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 454166007674 lysine decarboxylase CadA; Provisional; Region: PRK15400 454166007675 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454166007676 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454166007677 homodimer interface [polypeptide binding]; other site 454166007678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166007679 catalytic residue [active] 454166007680 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454166007681 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 454166007682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007683 putative substrate translocation pore; other site 454166007684 POT family; Region: PTR2; pfam00854 454166007685 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 454166007686 Nitrogen regulatory protein P-II; Region: P-II; smart00938 454166007687 response regulator GlrR; Provisional; Region: PRK15115 454166007688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166007689 active site 454166007690 phosphorylation site [posttranslational modification] 454166007691 intermolecular recognition site; other site 454166007692 dimerization interface [polypeptide binding]; other site 454166007693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166007694 Walker A motif; other site 454166007695 ATP binding site [chemical binding]; other site 454166007696 Walker B motif; other site 454166007697 arginine finger; other site 454166007698 hypothetical protein; Provisional; Region: PRK10722 454166007699 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 454166007700 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 454166007701 dimerization interface [polypeptide binding]; other site 454166007702 ATP binding site [chemical binding]; other site 454166007703 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 454166007704 dimerization interface [polypeptide binding]; other site 454166007705 ATP binding site [chemical binding]; other site 454166007706 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 454166007707 putative active site [active] 454166007708 catalytic triad [active] 454166007709 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 454166007710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166007711 substrate binding pocket [chemical binding]; other site 454166007712 membrane-bound complex binding site; other site 454166007713 hinge residues; other site 454166007714 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166007715 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166007716 catalytic residue [active] 454166007717 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 454166007718 nucleoside/Zn binding site; other site 454166007719 dimer interface [polypeptide binding]; other site 454166007720 catalytic motif [active] 454166007721 hypothetical protein; Provisional; Region: PRK11590 454166007722 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 454166007723 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 454166007724 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454166007725 active site turn [active] 454166007726 phosphorylation site [posttranslational modification] 454166007727 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454166007728 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 454166007729 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 454166007730 putative active site [active] 454166007731 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 454166007732 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 454166007733 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 454166007734 putative active site [active] 454166007735 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 454166007736 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 454166007737 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 454166007738 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 454166007739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007740 putative substrate translocation pore; other site 454166007741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166007742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166007743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166007744 dimerization interface [polypeptide binding]; other site 454166007745 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 454166007746 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 454166007747 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 454166007748 active site 454166007749 hydrophilic channel; other site 454166007750 dimerization interface [polypeptide binding]; other site 454166007751 catalytic residues [active] 454166007752 active site lid [active] 454166007753 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 454166007754 Recombination protein O N terminal; Region: RecO_N; pfam11967 454166007755 Recombination protein O C terminal; Region: RecO_C; pfam02565 454166007756 GTPase Era; Reviewed; Region: era; PRK00089 454166007757 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 454166007758 G1 box; other site 454166007759 GTP/Mg2+ binding site [chemical binding]; other site 454166007760 Switch I region; other site 454166007761 G2 box; other site 454166007762 Switch II region; other site 454166007763 G3 box; other site 454166007764 G4 box; other site 454166007765 G5 box; other site 454166007766 KH domain; Region: KH_2; pfam07650 454166007767 ribonuclease III; Reviewed; Region: rnc; PRK00102 454166007768 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 454166007769 dimerization interface [polypeptide binding]; other site 454166007770 active site 454166007771 metal binding site [ion binding]; metal-binding site 454166007772 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 454166007773 dsRNA binding site [nucleotide binding]; other site 454166007774 rncO 454166007775 signal peptidase I; Provisional; Region: PRK10861 454166007776 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 454166007777 Catalytic site [active] 454166007778 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 454166007779 GTP-binding protein LepA; Provisional; Region: PRK05433 454166007780 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 454166007781 G1 box; other site 454166007782 putative GEF interaction site [polypeptide binding]; other site 454166007783 GTP/Mg2+ binding site [chemical binding]; other site 454166007784 Switch I region; other site 454166007785 G2 box; other site 454166007786 G3 box; other site 454166007787 Switch II region; other site 454166007788 G4 box; other site 454166007789 G5 box; other site 454166007790 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 454166007791 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 454166007792 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 454166007793 SoxR reducing system protein RseC; Provisional; Region: PRK10862 454166007794 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 454166007795 anti-sigma E factor; Provisional; Region: rseB; PRK09455 454166007796 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 454166007797 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 454166007798 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 454166007799 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 454166007800 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454166007801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454166007802 DNA binding residues [nucleotide binding] 454166007803 L-aspartate oxidase; Provisional; Region: PRK09077 454166007804 L-aspartate oxidase; Provisional; Region: PRK06175 454166007805 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 454166007806 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 454166007807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166007808 S-adenosylmethionine binding site [chemical binding]; other site 454166007809 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 454166007810 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454166007811 ATP binding site [chemical binding]; other site 454166007812 Mg++ binding site [ion binding]; other site 454166007813 motif III; other site 454166007814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166007815 nucleotide binding region [chemical binding]; other site 454166007816 ATP-binding site [chemical binding]; other site 454166007817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166007818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166007819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166007820 dimerization interface [polypeptide binding]; other site 454166007821 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 454166007822 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 454166007823 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 454166007824 ligand binding site [chemical binding]; other site 454166007825 active site 454166007826 UGI interface [polypeptide binding]; other site 454166007827 catalytic site [active] 454166007828 putative methyltransferase; Provisional; Region: PRK10864 454166007829 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 454166007830 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 454166007831 thioredoxin 2; Provisional; Region: PRK10996 454166007832 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 454166007833 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 454166007834 catalytic residues [active] 454166007835 Uncharacterized conserved protein [Function unknown]; Region: COG3148 454166007836 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 454166007837 CoA binding domain; Region: CoA_binding_2; pfam13380 454166007838 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 454166007839 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 454166007840 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 454166007841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166007842 Coenzyme A binding pocket [chemical binding]; other site 454166007843 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 454166007844 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 454166007845 domain interface [polypeptide binding]; other site 454166007846 putative active site [active] 454166007847 catalytic site [active] 454166007848 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 454166007849 domain interface [polypeptide binding]; other site 454166007850 putative active site [active] 454166007851 catalytic site [active] 454166007852 lipoprotein; Provisional; Region: PRK10759 454166007853 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 454166007854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166007855 putative substrate translocation pore; other site 454166007856 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 454166007857 protein disaggregation chaperone; Provisional; Region: PRK10865 454166007858 Clp amino terminal domain; Region: Clp_N; pfam02861 454166007859 Clp amino terminal domain; Region: Clp_N; pfam02861 454166007860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166007861 Walker A motif; other site 454166007862 ATP binding site [chemical binding]; other site 454166007863 Walker B motif; other site 454166007864 arginine finger; other site 454166007865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166007866 Walker A motif; other site 454166007867 ATP binding site [chemical binding]; other site 454166007868 Walker B motif; other site 454166007869 arginine finger; other site 454166007870 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 454166007871 hypothetical protein; Provisional; Region: PRK10723 454166007872 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 454166007873 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 454166007874 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166007875 RNA binding surface [nucleotide binding]; other site 454166007876 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 454166007877 active site 454166007878 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 454166007879 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 454166007880 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 454166007881 30S subunit binding site; other site 454166007882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166007883 AAA domain; Region: AAA_21; pfam13304 454166007884 Walker A/P-loop; other site 454166007885 ATP binding site [chemical binding]; other site 454166007886 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 454166007887 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 454166007888 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 454166007889 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 454166007890 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 454166007891 Baseplate J-like protein; Region: Baseplate_J; cl01294 454166007892 Baseplate J-like protein; Region: Baseplate_J; pfam04865 454166007893 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 454166007894 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 454166007895 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 454166007896 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 454166007897 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 454166007898 Phage holin family 2; Region: Phage_holin_2; pfam04550 454166007899 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 454166007900 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 454166007901 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 454166007902 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 454166007903 terminase endonuclease subunit; Provisional; Region: M; PHA02537 454166007904 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 454166007905 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 454166007906 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 454166007907 terminase ATPase subunit; Provisional; Region: P; PHA02535 454166007908 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 454166007909 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 454166007910 Phage-related protein [Function unknown]; Region: COG4695; cl01923 454166007911 Phage portal protein; Region: Phage_portal; pfam04860 454166007912 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 454166007913 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 454166007914 active site 454166007915 metal binding site [ion binding]; metal-binding site 454166007916 interdomain interaction site; other site 454166007917 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 454166007918 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 454166007919 integrase; Provisional; Region: int; PHA02601 454166007920 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454166007921 active site 454166007922 DNA binding site [nucleotide binding] 454166007923 Int/Topo IB signature motif; other site 454166007924 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 454166007925 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 454166007926 Prephenate dehydratase; Region: PDT; pfam00800 454166007927 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 454166007928 putative L-Phe binding site [chemical binding]; other site 454166007929 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 454166007930 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 454166007931 Chorismate mutase type II; Region: CM_2; cl00693 454166007932 prephenate dehydrogenase; Validated; Region: PRK08507 454166007933 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 454166007934 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 454166007935 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 454166007936 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 454166007937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166007938 metal binding site [ion binding]; metal-binding site 454166007939 active site 454166007940 I-site; other site 454166007941 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 454166007942 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 454166007943 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 454166007944 RimM N-terminal domain; Region: RimM; pfam01782 454166007945 PRC-barrel domain; Region: PRC; pfam05239 454166007946 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 454166007947 signal recognition particle protein; Provisional; Region: PRK10867 454166007948 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 454166007949 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 454166007950 P loop; other site 454166007951 GTP binding site [chemical binding]; other site 454166007952 Signal peptide binding domain; Region: SRP_SPB; pfam02978 454166007953 hypothetical protein; Provisional; Region: PRK11573 454166007954 Domain of unknown function DUF21; Region: DUF21; pfam01595 454166007955 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454166007956 Transporter associated domain; Region: CorC_HlyC; smart01091 454166007957 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 454166007958 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 454166007959 dimer interface [polypeptide binding]; other site 454166007960 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 454166007961 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 454166007962 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 454166007963 recombination and repair protein; Provisional; Region: PRK10869 454166007964 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 454166007965 Walker A/P-loop; other site 454166007966 ATP binding site [chemical binding]; other site 454166007967 Q-loop/lid; other site 454166007968 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 454166007969 ABC transporter signature motif; other site 454166007970 Walker B; other site 454166007971 D-loop; other site 454166007972 H-loop/switch region; other site 454166007973 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 454166007974 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 454166007975 hypothetical protein; Validated; Region: PRK01777 454166007976 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 454166007977 putative coenzyme Q binding site [chemical binding]; other site 454166007978 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 454166007979 SmpB-tmRNA interface; other site 454166007980 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007981 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007982 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007983 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007984 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007985 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007986 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007987 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007988 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007989 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007990 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007991 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007992 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007993 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454166007994 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007995 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166007996 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 454166007997 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 454166007998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166007999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166008000 Walker A/P-loop; other site 454166008001 ATP binding site [chemical binding]; other site 454166008002 Q-loop/lid; other site 454166008003 ABC transporter signature motif; other site 454166008004 Walker B; other site 454166008005 D-loop; other site 454166008006 H-loop/switch region; other site 454166008007 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 454166008008 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166008009 tail protein; Provisional; Region: D; PHA02561 454166008010 Phage protein U [General function prediction only]; Region: COG3499 454166008011 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 454166008012 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 454166008013 major tail tube protein; Provisional; Region: FII; PHA02600 454166008014 major tail sheath protein; Provisional; Region: FI; PHA02560 454166008015 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 454166008016 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 454166008017 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 454166008018 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 454166008019 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 454166008020 baseplate assembly protein; Provisional; Region: J; PHA02568 454166008021 baseplate wedge subunit; Provisional; Region: W; PHA02516 454166008022 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 454166008023 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 454166008024 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 454166008025 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 454166008026 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 454166008027 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 454166008028 catalytic residues [active] 454166008029 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 454166008030 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 454166008031 terminase endonuclease subunit; Provisional; Region: M; PHA02537 454166008032 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 454166008033 capsid protein; Provisional; Region: N; PHA02538 454166008034 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 454166008035 terminase ATPase subunit; Provisional; Region: P; PHA02535 454166008036 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 454166008037 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 454166008038 portal vertex protein; Provisional; Region: Q; PHA02536 454166008039 Phage portal protein; Region: Phage_portal; pfam04860 454166008040 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 454166008041 DNA adenine methylase (dam); Region: dam; TIGR00571 454166008042 DksA-like zinc finger domain containing protein; Region: PHA00080 454166008043 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 454166008044 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 454166008045 integrase; Provisional; Region: int; PHA02601 454166008046 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 454166008047 dimer interface [polypeptide binding]; other site 454166008048 active site 454166008049 catalytic residues [active] 454166008050 Int/Topo IB signature motif; other site 454166008051 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 454166008052 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 454166008053 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 454166008054 homodimer interface [polypeptide binding]; other site 454166008055 active site 454166008056 TDP-binding site; other site 454166008057 acceptor substrate-binding pocket; other site 454166008058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166008059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166008060 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 454166008061 Walker A/P-loop; other site 454166008062 ATP binding site [chemical binding]; other site 454166008063 Q-loop/lid; other site 454166008064 ABC transporter signature motif; other site 454166008065 Walker B; other site 454166008066 D-loop; other site 454166008067 H-loop/switch region; other site 454166008068 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 454166008069 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 454166008070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166008071 Walker A/P-loop; other site 454166008072 ATP binding site [chemical binding]; other site 454166008073 Q-loop/lid; other site 454166008074 ABC transporter signature motif; other site 454166008075 Walker B; other site 454166008076 D-loop; other site 454166008077 H-loop/switch region; other site 454166008078 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 454166008079 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 454166008080 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 454166008081 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 454166008082 outer membrane receptor FepA; Provisional; Region: PRK13528 454166008083 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166008084 N-terminal plug; other site 454166008085 ligand-binding site [chemical binding]; other site 454166008086 secreted effector protein PipB2; Provisional; Region: PRK15196 454166008087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454166008088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454166008089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454166008090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454166008091 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 454166008092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 454166008093 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 454166008094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 454166008095 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 454166008096 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 454166008097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 454166008098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 454166008099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166008100 dimer interface [polypeptide binding]; other site 454166008101 phosphorylation site [posttranslational modification] 454166008102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166008103 ATP binding site [chemical binding]; other site 454166008104 Mg2+ binding site [ion binding]; other site 454166008105 G-X-G motif; other site 454166008106 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 454166008107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166008108 active site 454166008109 phosphorylation site [posttranslational modification] 454166008110 intermolecular recognition site; other site 454166008111 dimerization interface [polypeptide binding]; other site 454166008112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166008113 DNA binding site [nucleotide binding] 454166008114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 454166008115 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 454166008116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 454166008117 Predicted dehydrogenase [General function prediction only]; Region: COG0579 454166008118 hydroxyglutarate oxidase; Provisional; Region: PRK11728 454166008119 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 454166008120 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 454166008121 tetramerization interface [polypeptide binding]; other site 454166008122 NAD(P) binding site [chemical binding]; other site 454166008123 catalytic residues [active] 454166008124 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 454166008125 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454166008126 inhibitor-cofactor binding pocket; inhibition site 454166008127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166008128 catalytic residue [active] 454166008129 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 454166008130 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 454166008131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166008132 DNA-binding site [nucleotide binding]; DNA binding site 454166008133 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454166008134 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 454166008135 bacterial OsmY and nodulation domain; Region: BON; smart00749 454166008136 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166008137 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 454166008138 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166008139 dimerization interface [polypeptide binding]; other site 454166008140 putative DNA binding site [nucleotide binding]; other site 454166008141 putative Zn2+ binding site [ion binding]; other site 454166008142 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 454166008143 active site residue [active] 454166008144 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 454166008145 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 454166008146 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 454166008147 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 454166008148 hypothetical protein; Provisional; Region: PRK10556 454166008149 hypothetical protein; Provisional; Region: PRK10132 454166008150 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 454166008151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166008152 DNA-binding site [nucleotide binding]; DNA binding site 454166008153 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166008154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166008155 homodimer interface [polypeptide binding]; other site 454166008156 catalytic residue [active] 454166008157 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 454166008158 Uncharacterized conserved protein [Function unknown]; Region: COG2128 454166008159 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 454166008160 catalytic residues [active] 454166008161 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 454166008162 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 454166008163 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 454166008164 Class I ribonucleotide reductase; Region: RNR_I; cd01679 454166008165 active site 454166008166 dimer interface [polypeptide binding]; other site 454166008167 catalytic residues [active] 454166008168 effector binding site; other site 454166008169 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 454166008170 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 454166008171 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 454166008172 dimer interface [polypeptide binding]; other site 454166008173 putative radical transfer pathway; other site 454166008174 diiron center [ion binding]; other site 454166008175 tyrosyl radical; other site 454166008176 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 454166008177 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 454166008178 Walker A/P-loop; other site 454166008179 ATP binding site [chemical binding]; other site 454166008180 Q-loop/lid; other site 454166008181 ABC transporter signature motif; other site 454166008182 Walker B; other site 454166008183 D-loop; other site 454166008184 H-loop/switch region; other site 454166008185 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 454166008186 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 454166008187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166008188 dimer interface [polypeptide binding]; other site 454166008189 conserved gate region; other site 454166008190 putative PBP binding loops; other site 454166008191 ABC-ATPase subunit interface; other site 454166008192 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 454166008193 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 454166008194 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 454166008195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008196 transcriptional repressor MprA; Provisional; Region: PRK10870 454166008197 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 454166008198 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 454166008199 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166008200 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166008201 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 454166008202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008203 putative substrate translocation pore; other site 454166008204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008205 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 454166008206 S-ribosylhomocysteinase; Provisional; Region: PRK02260 454166008207 glutamate--cysteine ligase; Provisional; Region: PRK02107 454166008208 Predicted membrane protein [Function unknown]; Region: COG1238 454166008209 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 454166008210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166008211 carbon storage regulator; Provisional; Region: PRK01712 454166008212 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 454166008213 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 454166008214 motif 1; other site 454166008215 active site 454166008216 motif 2; other site 454166008217 motif 3; other site 454166008218 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 454166008219 DHHA1 domain; Region: DHHA1; pfam02272 454166008220 recombination regulator RecX; Reviewed; Region: recX; PRK00117 454166008221 recombinase A; Provisional; Region: recA; PRK09354 454166008222 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 454166008223 hexamer interface [polypeptide binding]; other site 454166008224 Walker A motif; other site 454166008225 ATP binding site [chemical binding]; other site 454166008226 Walker B motif; other site 454166008227 hypothetical protein; Validated; Region: PRK03661 454166008228 Transglycosylase SLT domain; Region: SLT_2; pfam13406 454166008229 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166008230 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166008231 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 454166008232 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 454166008233 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 454166008234 Nucleoside recognition; Region: Gate; pfam07670 454166008235 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 454166008236 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 454166008237 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 454166008238 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 454166008239 putative NAD(P) binding site [chemical binding]; other site 454166008240 active site 454166008241 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 454166008242 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 454166008243 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454166008244 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166008245 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 454166008246 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 454166008247 putative active site [active] 454166008248 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 454166008249 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 454166008250 GAF domain; Region: GAF; pfam01590 454166008251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166008252 Walker A motif; other site 454166008253 ATP binding site [chemical binding]; other site 454166008254 Walker B motif; other site 454166008255 arginine finger; other site 454166008256 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 454166008257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 454166008258 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 454166008259 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 454166008260 iron binding site [ion binding]; other site 454166008261 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 454166008262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166008263 Acylphosphatase; Region: Acylphosphatase; pfam00708 454166008264 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 454166008265 HypF finger; Region: zf-HYPF; pfam07503 454166008266 HypF finger; Region: zf-HYPF; pfam07503 454166008267 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 454166008268 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 454166008269 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 454166008270 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 454166008271 nickel binding site [ion binding]; other site 454166008272 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 454166008273 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 454166008274 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 454166008275 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 454166008276 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 454166008277 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 454166008278 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 454166008279 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 454166008280 NADH dehydrogenase; Region: NADHdh; cl00469 454166008281 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 454166008282 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 454166008283 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 454166008284 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 454166008285 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 454166008286 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 454166008287 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 454166008288 hydrogenase assembly chaperone; Provisional; Region: PRK10409 454166008289 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 454166008290 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 454166008291 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 454166008292 dimerization interface [polypeptide binding]; other site 454166008293 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 454166008294 ATP binding site [chemical binding]; other site 454166008295 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 454166008296 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 454166008297 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 454166008298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166008299 Walker A motif; other site 454166008300 ATP binding site [chemical binding]; other site 454166008301 Walker B motif; other site 454166008302 arginine finger; other site 454166008303 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454166008304 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 454166008305 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 454166008306 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 454166008307 metal binding site [ion binding]; metal-binding site 454166008308 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 454166008309 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 454166008310 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 454166008311 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166008312 ABC-ATPase subunit interface; other site 454166008313 dimer interface [polypeptide binding]; other site 454166008314 putative PBP binding regions; other site 454166008315 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 454166008316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 454166008317 ABC-ATPase subunit interface; other site 454166008318 dimer interface [polypeptide binding]; other site 454166008319 putative PBP binding regions; other site 454166008320 effector protein YopJ; Provisional; Region: PRK15371 454166008321 transcriptional activator SprB; Provisional; Region: PRK15320 454166008322 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 454166008323 transcriptional regulator SirC; Provisional; Region: PRK15044 454166008324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166008325 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 454166008326 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 454166008327 invasion protein OrgA; Provisional; Region: PRK15323 454166008328 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 454166008329 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 454166008330 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 454166008331 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 454166008332 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 454166008333 transcriptional regulator HilD; Provisional; Region: PRK15185 454166008334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166008335 invasion protein regulator; Provisional; Region: PRK12370 454166008336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166008337 DNA binding site [nucleotide binding] 454166008338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166008339 binding surface 454166008340 TPR motif; other site 454166008341 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 454166008342 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166008343 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166008344 catalytic residue [active] 454166008345 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 454166008346 SicP binding; Region: SicP-binding; pfam09119 454166008347 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 454166008348 switch II binding region; other site 454166008349 Rac1 P-loop interaction site [polypeptide binding]; other site 454166008350 GTP binding residues [chemical binding]; other site 454166008351 switch I binding region; other site 454166008352 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 454166008353 active site 454166008354 chaperone protein SicP; Provisional; Region: PRK15329 454166008355 putative acyl carrier protein IacP; Validated; Region: PRK08172 454166008356 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 454166008357 cell invasion protein SipD; Provisional; Region: PRK15330 454166008358 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 454166008359 chaperone protein SicA; Provisional; Region: PRK15331 454166008360 Tetratricopeptide repeat; Region: TPR_3; pfam07720 454166008361 Tetratricopeptide repeat; Region: TPR_3; pfam07720 454166008362 type III secretion system protein SpaS; Validated; Region: PRK08156 454166008363 type III secretion system protein SpaR; Provisional; Region: PRK15332 454166008364 type III secretion system protein SpaQ; Provisional; Region: PRK15333 454166008365 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 454166008366 type III secretion system protein SpaO; Validated; Region: PRK08158 454166008367 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 454166008368 antigen presentation protein SpaN; Provisional; Region: PRK15334 454166008369 Surface presentation of antigens protein; Region: SPAN; pfam02510 454166008370 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 454166008371 ATP synthase SpaL; Validated; Region: PRK08149 454166008372 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 454166008373 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 454166008374 Walker A motif; other site 454166008375 ATP binding site [chemical binding]; other site 454166008376 Walker B motif; other site 454166008377 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 454166008378 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 454166008379 type III secretion system protein InvA; Provisional; Region: PRK15337 454166008380 type III secretion system regulator InvE; Provisional; Region: PRK15338 454166008381 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 454166008382 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 454166008383 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 454166008384 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 454166008385 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 454166008386 transcriptional regulator InvF; Provisional; Region: PRK15340 454166008387 InvH outer membrane lipoprotein; Region: InvH; pfam04741 454166008388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 454166008389 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 454166008390 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454166008391 active site 454166008392 metal binding site [ion binding]; metal-binding site 454166008393 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 454166008394 MutS domain I; Region: MutS_I; pfam01624 454166008395 MutS domain II; Region: MutS_II; pfam05188 454166008396 MutS domain III; Region: MutS_III; pfam05192 454166008397 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 454166008398 Walker A/P-loop; other site 454166008399 ATP binding site [chemical binding]; other site 454166008400 Q-loop/lid; other site 454166008401 ABC transporter signature motif; other site 454166008402 Walker B; other site 454166008403 D-loop; other site 454166008404 H-loop/switch region; other site 454166008405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 454166008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 454166008408 putative substrate translocation pore; other site 454166008409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166008410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166008411 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 454166008412 putative effector binding pocket; other site 454166008413 dimerization interface [polypeptide binding]; other site 454166008414 GntP family permease; Region: GntP_permease; pfam02447 454166008415 fructuronate transporter; Provisional; Region: PRK10034; cl15264 454166008416 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 454166008417 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 454166008418 putative NAD(P) binding site [chemical binding]; other site 454166008419 active site 454166008420 putative substrate binding site [chemical binding]; other site 454166008421 hypothetical protein; Provisional; Region: PRK09989 454166008422 putative aldolase; Validated; Region: PRK08130 454166008423 intersubunit interface [polypeptide binding]; other site 454166008424 active site 454166008425 Zn2+ binding site [ion binding]; other site 454166008426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 454166008427 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 454166008428 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454166008429 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166008430 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454166008431 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166008432 MarR family; Region: MarR_2; cl17246 454166008433 Transcriptional regulators [Transcription]; Region: MarR; COG1846 454166008434 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 454166008435 Flavoprotein; Region: Flavoprotein; pfam02441 454166008436 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 454166008437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454166008438 DNA binding residues [nucleotide binding] 454166008439 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454166008440 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 454166008441 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 454166008442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454166008443 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 454166008444 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 454166008445 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166008446 Peptidase family M23; Region: Peptidase_M23; pfam01551 454166008447 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 454166008448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166008449 S-adenosylmethionine binding site [chemical binding]; other site 454166008450 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 454166008451 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 454166008452 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 454166008453 Permutation of conserved domain; other site 454166008454 active site 454166008455 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 454166008456 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 454166008457 homotrimer interaction site [polypeptide binding]; other site 454166008458 zinc binding site [ion binding]; other site 454166008459 CDP-binding sites; other site 454166008460 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 454166008461 substrate binding site; other site 454166008462 dimer interface; other site 454166008463 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 454166008464 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 454166008465 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 454166008466 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 454166008467 ligand-binding site [chemical binding]; other site 454166008468 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 454166008469 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 454166008470 CysD dimerization site [polypeptide binding]; other site 454166008471 G1 box; other site 454166008472 putative GEF interaction site [polypeptide binding]; other site 454166008473 GTP/Mg2+ binding site [chemical binding]; other site 454166008474 Switch I region; other site 454166008475 G2 box; other site 454166008476 G3 box; other site 454166008477 Switch II region; other site 454166008478 G4 box; other site 454166008479 G5 box; other site 454166008480 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 454166008481 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 454166008482 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 454166008483 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 454166008484 Active Sites [active] 454166008485 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 454166008486 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 454166008487 metal binding site [ion binding]; metal-binding site 454166008488 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 454166008489 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 454166008490 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 454166008491 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 454166008492 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 454166008493 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 454166008494 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 454166008495 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 454166008496 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 454166008497 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 454166008498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 454166008499 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 454166008500 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 454166008501 Active Sites [active] 454166008502 sulfite reductase subunit beta; Provisional; Region: PRK13504 454166008503 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454166008504 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454166008505 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 454166008506 Flavodoxin; Region: Flavodoxin_1; pfam00258 454166008507 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 454166008508 FAD binding pocket [chemical binding]; other site 454166008509 FAD binding motif [chemical binding]; other site 454166008510 catalytic residues [active] 454166008511 NAD binding pocket [chemical binding]; other site 454166008512 phosphate binding motif [ion binding]; other site 454166008513 beta-alpha-beta structure motif; other site 454166008514 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 454166008515 active site 454166008516 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 454166008517 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 454166008518 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 454166008519 enolase; Provisional; Region: eno; PRK00077 454166008520 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 454166008521 dimer interface [polypeptide binding]; other site 454166008522 metal binding site [ion binding]; metal-binding site 454166008523 substrate binding pocket [chemical binding]; other site 454166008524 CTP synthetase; Validated; Region: pyrG; PRK05380 454166008525 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 454166008526 Catalytic site [active] 454166008527 active site 454166008528 UTP binding site [chemical binding]; other site 454166008529 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 454166008530 active site 454166008531 putative oxyanion hole; other site 454166008532 catalytic triad [active] 454166008533 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 454166008534 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 454166008535 homodimer interface [polypeptide binding]; other site 454166008536 metal binding site [ion binding]; metal-binding site 454166008537 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 454166008538 homodimer interface [polypeptide binding]; other site 454166008539 active site 454166008540 putative chemical substrate binding site [chemical binding]; other site 454166008541 metal binding site [ion binding]; metal-binding site 454166008542 fimbrial protein SteA; Provisional; Region: PRK15261 454166008543 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 454166008544 PapC N-terminal domain; Region: PapC_N; pfam13954 454166008545 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166008546 PapC C-terminal domain; Region: PapC_C; pfam13953 454166008547 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 454166008548 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166008549 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166008550 putative fimbrial protein SteD; Provisional; Region: PRK15275 454166008551 putative fimbrial subunit SteE; Provisional; Region: PRK15276 454166008552 fimbrial protein SteF; Provisional; Region: PRK15260 454166008553 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 454166008554 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 454166008555 HD domain; Region: HD_4; pfam13328 454166008556 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 454166008557 synthetase active site [active] 454166008558 NTP binding site [chemical binding]; other site 454166008559 metal binding site [ion binding]; metal-binding site 454166008560 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 454166008561 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 454166008562 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 454166008563 TRAM domain; Region: TRAM; pfam01938 454166008564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166008565 S-adenosylmethionine binding site [chemical binding]; other site 454166008566 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 454166008567 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 454166008568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166008569 dimerization interface [polypeptide binding]; other site 454166008570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166008571 dimer interface [polypeptide binding]; other site 454166008572 phosphorylation site [posttranslational modification] 454166008573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166008574 ATP binding site [chemical binding]; other site 454166008575 Mg2+ binding site [ion binding]; other site 454166008576 G-X-G motif; other site 454166008577 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 454166008578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166008579 active site 454166008580 phosphorylation site [posttranslational modification] 454166008581 intermolecular recognition site; other site 454166008582 dimerization interface [polypeptide binding]; other site 454166008583 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454166008584 putative binding surface; other site 454166008585 active site 454166008586 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 454166008587 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 454166008588 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 454166008589 active site 454166008590 tetramer interface [polypeptide binding]; other site 454166008591 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 454166008592 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 454166008593 active site 454166008594 tetramer interface [polypeptide binding]; other site 454166008595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008596 D-galactonate transporter; Region: 2A0114; TIGR00893 454166008597 putative substrate translocation pore; other site 454166008598 flavodoxin; Provisional; Region: PRK08105 454166008599 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 454166008600 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 454166008601 probable active site [active] 454166008602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 454166008603 SecY interacting protein Syd; Provisional; Region: PRK04968 454166008604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 454166008605 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 454166008606 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 454166008607 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 454166008608 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 454166008609 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454166008610 serine transporter; Region: stp; TIGR00814 454166008611 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 454166008612 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454166008613 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454166008614 flap endonuclease-like protein; Provisional; Region: PRK09482 454166008615 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 454166008616 active site 454166008617 metal binding site 1 [ion binding]; metal-binding site 454166008618 putative 5' ssDNA interaction site; other site 454166008619 metal binding site 3; metal-binding site 454166008620 metal binding site 2 [ion binding]; metal-binding site 454166008621 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 454166008622 putative DNA binding site [nucleotide binding]; other site 454166008623 putative metal binding site [ion binding]; other site 454166008624 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 454166008625 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 454166008626 dimer interface [polypeptide binding]; other site 454166008627 active site 454166008628 metal binding site [ion binding]; metal-binding site 454166008629 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454166008630 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454166008631 intersubunit interface [polypeptide binding]; other site 454166008632 active site 454166008633 Zn2+ binding site [ion binding]; other site 454166008634 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 454166008635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008636 putative substrate translocation pore; other site 454166008637 L-fucose isomerase; Provisional; Region: fucI; PRK10991 454166008638 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 454166008639 hexamer (dimer of trimers) interface [polypeptide binding]; other site 454166008640 trimer interface [polypeptide binding]; other site 454166008641 substrate binding site [chemical binding]; other site 454166008642 Mn binding site [ion binding]; other site 454166008643 L-fuculokinase; Provisional; Region: PRK10331 454166008644 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 454166008645 nucleotide binding site [chemical binding]; other site 454166008646 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 454166008647 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 454166008648 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454166008649 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166008650 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 454166008651 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 454166008652 hypothetical protein; Provisional; Region: PRK10873 454166008653 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 454166008654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166008655 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 454166008656 dimerization interface [polypeptide binding]; other site 454166008657 substrate binding pocket [chemical binding]; other site 454166008658 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454166008659 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 454166008660 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 454166008661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166008662 catalytic residue [active] 454166008663 CsdA-binding activator; Provisional; Region: PRK15019 454166008664 Predicted permeases [General function prediction only]; Region: RarD; COG2962 454166008665 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 454166008666 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 454166008667 putative ATP binding site [chemical binding]; other site 454166008668 putative substrate interface [chemical binding]; other site 454166008669 N-acetylglutamate synthase; Validated; Region: PRK05279 454166008670 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 454166008671 putative feedback inhibition sensing region; other site 454166008672 putative nucleotide binding site [chemical binding]; other site 454166008673 putative substrate binding site [chemical binding]; other site 454166008674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166008675 Coenzyme A binding pocket [chemical binding]; other site 454166008676 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 454166008677 AAA domain; Region: AAA_30; pfam13604 454166008678 Family description; Region: UvrD_C_2; pfam13538 454166008679 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 454166008680 protease3; Provisional; Region: PRK15101 454166008681 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 454166008682 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 454166008683 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 454166008684 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 454166008685 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 454166008686 hypothetical protein; Provisional; Region: PRK10332 454166008687 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 454166008688 hypothetical protein; Provisional; Region: PRK11521 454166008689 hypothetical protein; Provisional; Region: PRK10557 454166008690 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 454166008691 hypothetical protein; Provisional; Region: PRK10506 454166008692 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 454166008693 thymidylate synthase; Reviewed; Region: thyA; PRK01827 454166008694 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 454166008695 dimerization interface [polypeptide binding]; other site 454166008696 active site 454166008697 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 454166008698 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 454166008699 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 454166008700 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 454166008701 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 454166008702 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 454166008703 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 454166008704 putative active site [active] 454166008705 Ap4A binding site [chemical binding]; other site 454166008706 nudix motif; other site 454166008707 putative metal binding site [ion binding]; other site 454166008708 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 454166008709 putative DNA-binding cleft [nucleotide binding]; other site 454166008710 putative DNA clevage site; other site 454166008711 molecular lever; other site 454166008712 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 454166008713 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 454166008714 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166008715 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166008716 active site 454166008717 catalytic tetrad [active] 454166008718 lysophospholipid transporter LplT; Provisional; Region: PRK11195 454166008719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008720 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 454166008721 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 454166008722 putative acyl-acceptor binding pocket; other site 454166008723 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 454166008724 acyl-activating enzyme (AAE) consensus motif; other site 454166008725 putative AMP binding site [chemical binding]; other site 454166008726 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 454166008727 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166008728 DNA binding site [nucleotide binding] 454166008729 domain linker motif; other site 454166008730 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454166008731 dimerization interface (closed form) [polypeptide binding]; other site 454166008732 ligand binding site [chemical binding]; other site 454166008733 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454166008734 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166008735 DNA binding site [nucleotide binding] 454166008736 domain linker motif; other site 454166008737 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 454166008738 dimerization interface (closed form) [polypeptide binding]; other site 454166008739 ligand binding site [chemical binding]; other site 454166008740 diaminopimelate decarboxylase; Provisional; Region: PRK11165 454166008741 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 454166008742 active site 454166008743 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454166008744 substrate binding site [chemical binding]; other site 454166008745 catalytic residues [active] 454166008746 dimer interface [polypeptide binding]; other site 454166008747 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 454166008748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166008749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166008750 dimerization interface [polypeptide binding]; other site 454166008751 putative racemase; Provisional; Region: PRK10200 454166008752 aspartate racemase; Region: asp_race; TIGR00035 454166008753 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 454166008754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008755 putative substrate translocation pore; other site 454166008756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008757 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 454166008758 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 454166008759 NADP binding site [chemical binding]; other site 454166008760 homodimer interface [polypeptide binding]; other site 454166008761 active site 454166008762 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 454166008763 putative acyltransferase; Provisional; Region: PRK05790 454166008764 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 454166008765 dimer interface [polypeptide binding]; other site 454166008766 active site 454166008767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166008768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166008769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166008770 dimerization interface [polypeptide binding]; other site 454166008771 Predicted membrane protein [Function unknown]; Region: COG4125 454166008772 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 454166008773 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 454166008774 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Region: PLN02475 454166008775 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454166008776 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 454166008777 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 454166008778 putative metal binding site [ion binding]; other site 454166008779 putative homodimer interface [polypeptide binding]; other site 454166008780 putative homotetramer interface [polypeptide binding]; other site 454166008781 putative homodimer-homodimer interface [polypeptide binding]; other site 454166008782 putative allosteric switch controlling residues; other site 454166008783 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 454166008784 transcriptional activator SprB; Provisional; Region: PRK15320 454166008785 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 454166008786 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 454166008787 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454166008788 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 454166008789 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166008790 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166008791 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 454166008792 PapC N-terminal domain; Region: PapC_N; pfam13954 454166008793 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166008794 PapC C-terminal domain; Region: PapC_C; pfam13953 454166008795 fimbrial protein StdA; Provisional; Region: PRK15210 454166008796 hypothetical protein; Provisional; Region: PRK10316 454166008797 YfdX protein; Region: YfdX; pfam10938 454166008798 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 454166008799 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 454166008800 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 454166008801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 454166008802 Peptidase family M23; Region: Peptidase_M23; pfam01551 454166008803 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 454166008804 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 454166008805 active site 454166008806 metal binding site [ion binding]; metal-binding site 454166008807 nudix motif; other site 454166008808 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 454166008809 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 454166008810 dimer interface [polypeptide binding]; other site 454166008811 putative anticodon binding site; other site 454166008812 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 454166008813 motif 1; other site 454166008814 active site 454166008815 motif 2; other site 454166008816 motif 3; other site 454166008817 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 454166008818 DHH family; Region: DHH; pfam01368 454166008819 DHHA1 domain; Region: DHHA1; pfam02272 454166008820 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 454166008821 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 454166008822 dimerization domain [polypeptide binding]; other site 454166008823 dimer interface [polypeptide binding]; other site 454166008824 catalytic residues [active] 454166008825 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 454166008826 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 454166008827 active site 454166008828 Int/Topo IB signature motif; other site 454166008829 flavodoxin FldB; Provisional; Region: PRK12359 454166008830 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 454166008831 hypothetical protein; Provisional; Region: PRK10878 454166008832 putative global regulator; Reviewed; Region: PRK09559 454166008833 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 454166008834 hemolysin; Provisional; Region: PRK15087 454166008835 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 454166008836 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 454166008837 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 454166008838 beta-galactosidase; Region: BGL; TIGR03356 454166008839 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 454166008840 glycine dehydrogenase; Provisional; Region: PRK05367 454166008841 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 454166008842 tetramer interface [polypeptide binding]; other site 454166008843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166008844 catalytic residue [active] 454166008845 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 454166008846 tetramer interface [polypeptide binding]; other site 454166008847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166008848 catalytic residue [active] 454166008849 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 454166008850 lipoyl attachment site [posttranslational modification]; other site 454166008851 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 454166008852 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 454166008853 oxidoreductase; Provisional; Region: PRK08013 454166008854 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 454166008855 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 454166008856 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 454166008857 proline aminopeptidase P II; Provisional; Region: PRK10879 454166008858 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 454166008859 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 454166008860 active site 454166008861 hypothetical protein; Reviewed; Region: PRK01736 454166008862 Z-ring-associated protein; Provisional; Region: PRK10972 454166008863 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 454166008864 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 454166008865 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 454166008866 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 454166008867 ligand binding site [chemical binding]; other site 454166008868 NAD binding site [chemical binding]; other site 454166008869 tetramer interface [polypeptide binding]; other site 454166008870 catalytic site [active] 454166008871 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 454166008872 L-serine binding site [chemical binding]; other site 454166008873 ACT domain interface; other site 454166008874 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 454166008875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166008876 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 454166008877 putative dimerization interface [polypeptide binding]; other site 454166008878 Uncharacterized conserved protein [Function unknown]; Region: COG2968 454166008879 oxidative stress defense protein; Provisional; Region: PRK11087 454166008880 arginine exporter protein; Provisional; Region: PRK09304 454166008881 mechanosensitive channel MscS; Provisional; Region: PRK10334 454166008882 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166008883 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 454166008884 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 454166008885 active site 454166008886 intersubunit interface [polypeptide binding]; other site 454166008887 zinc binding site [ion binding]; other site 454166008888 Na+ binding site [ion binding]; other site 454166008889 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 454166008890 Phosphoglycerate kinase; Region: PGK; pfam00162 454166008891 substrate binding site [chemical binding]; other site 454166008892 hinge regions; other site 454166008893 ADP binding site [chemical binding]; other site 454166008894 catalytic site [active] 454166008895 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 454166008896 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 454166008897 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 454166008898 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 454166008899 trimer interface [polypeptide binding]; other site 454166008900 putative Zn binding site [ion binding]; other site 454166008901 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 454166008902 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 454166008903 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 454166008904 Walker A/P-loop; other site 454166008905 ATP binding site [chemical binding]; other site 454166008906 Q-loop/lid; other site 454166008907 ABC transporter signature motif; other site 454166008908 Walker B; other site 454166008909 D-loop; other site 454166008910 H-loop/switch region; other site 454166008911 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 454166008912 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 454166008913 Walker A/P-loop; other site 454166008914 ATP binding site [chemical binding]; other site 454166008915 Q-loop/lid; other site 454166008916 ABC transporter signature motif; other site 454166008917 Walker B; other site 454166008918 D-loop; other site 454166008919 H-loop/switch region; other site 454166008920 transketolase; Reviewed; Region: PRK12753 454166008921 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 454166008922 TPP-binding site [chemical binding]; other site 454166008923 dimer interface [polypeptide binding]; other site 454166008924 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 454166008925 PYR/PP interface [polypeptide binding]; other site 454166008926 dimer interface [polypeptide binding]; other site 454166008927 TPP binding site [chemical binding]; other site 454166008928 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 454166008929 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 454166008930 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 454166008931 agmatinase; Region: agmatinase; TIGR01230 454166008932 oligomer interface [polypeptide binding]; other site 454166008933 putative active site [active] 454166008934 Mn binding site [ion binding]; other site 454166008935 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 454166008936 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454166008937 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 454166008938 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454166008939 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 454166008940 putative NAD(P) binding site [chemical binding]; other site 454166008941 catalytic Zn binding site [ion binding]; other site 454166008942 structural Zn binding site [ion binding]; other site 454166008943 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 454166008944 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454166008945 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454166008946 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454166008947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166008948 DNA-binding site [nucleotide binding]; DNA binding site 454166008949 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454166008950 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 454166008951 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 454166008952 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 454166008953 dimer interface [polypeptide binding]; other site 454166008954 active site 454166008955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454166008956 catalytic residues [active] 454166008957 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 454166008958 Virulence promoting factor; Region: YqgB; pfam11036 454166008959 S-adenosylmethionine synthetase; Validated; Region: PRK05250 454166008960 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 454166008961 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 454166008962 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 454166008963 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 454166008964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008965 putative substrate translocation pore; other site 454166008966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166008967 hypothetical protein; Provisional; Region: PRK04860 454166008968 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 454166008969 DNA-specific endonuclease I; Provisional; Region: PRK15137 454166008970 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 454166008971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 454166008972 RNA methyltransferase, RsmE family; Region: TIGR00046 454166008973 glutathione synthetase; Provisional; Region: PRK05246 454166008974 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 454166008975 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 454166008976 hypothetical protein; Validated; Region: PRK00228 454166008977 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 454166008978 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 454166008979 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454166008980 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 454166008981 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 454166008982 Walker A motif; other site 454166008983 ATP binding site [chemical binding]; other site 454166008984 Walker B motif; other site 454166008985 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 454166008986 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454166008987 catalytic residue [active] 454166008988 YGGT family; Region: YGGT; pfam02325 454166008989 YGGT family; Region: YGGT; pfam02325 454166008990 hypothetical protein; Validated; Region: PRK05090 454166008991 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 454166008992 active site 454166008993 dimerization interface [polypeptide binding]; other site 454166008994 HemN family oxidoreductase; Provisional; Region: PRK05660 454166008995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166008996 FeS/SAM binding site; other site 454166008997 HemN C-terminal domain; Region: HemN_C; pfam06969 454166008998 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 454166008999 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 454166009000 homodimer interface [polypeptide binding]; other site 454166009001 active site 454166009002 hypothetical protein; Provisional; Region: PRK10626 454166009003 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 454166009004 hypothetical protein; Provisional; Region: PRK11702 454166009005 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 454166009006 adenine DNA glycosylase; Provisional; Region: PRK10880 454166009007 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 454166009008 minor groove reading motif; other site 454166009009 helix-hairpin-helix signature motif; other site 454166009010 substrate binding pocket [chemical binding]; other site 454166009011 active site 454166009012 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 454166009013 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 454166009014 DNA binding and oxoG recognition site [nucleotide binding] 454166009015 oxidative damage protection protein; Provisional; Region: PRK05408 454166009016 murein transglycosylase C; Provisional; Region: mltC; PRK11671 454166009017 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 454166009018 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166009019 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166009020 catalytic residue [active] 454166009021 nucleoside transporter; Region: 2A0110; TIGR00889 454166009022 ornithine decarboxylase; Provisional; Region: PRK13578 454166009023 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454166009024 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454166009025 homodimer interface [polypeptide binding]; other site 454166009026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166009027 catalytic residue [active] 454166009028 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454166009029 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 454166009030 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 454166009031 Protein of unknown function (DUF796); Region: DUF796; cl01226 454166009032 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 454166009033 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 454166009034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454166009035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166009036 DNA binding residues [nucleotide binding] 454166009037 dimerization interface [polypeptide binding]; other site 454166009038 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 454166009039 Amino acid permease; Region: AA_permease_2; pfam13520 454166009040 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 454166009041 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 454166009042 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 454166009043 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 454166009044 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 454166009045 NAD(P) binding site [chemical binding]; other site 454166009046 catalytic residues [active] 454166009047 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 454166009048 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 454166009049 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 454166009050 active site 454166009051 catalytic site [active] 454166009052 Zn binding site [ion binding]; other site 454166009053 tetramer interface [polypeptide binding]; other site 454166009054 Predicted amidohydrolase [General function prediction only]; Region: COG0388 454166009055 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 454166009056 putative active site [active] 454166009057 catalytic triad [active] 454166009058 putative dimer interface [polypeptide binding]; other site 454166009059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166009060 D-galactonate transporter; Region: 2A0114; TIGR00893 454166009061 putative substrate translocation pore; other site 454166009062 mannonate dehydratase; Provisional; Region: PRK03906 454166009063 mannonate dehydratase; Region: uxuA; TIGR00695 454166009064 D-mannonate oxidoreductase; Provisional; Region: PRK15037 454166009065 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454166009066 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454166009067 Glucuronate isomerase; Region: UxaC; pfam02614 454166009068 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 454166009069 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166009070 dimer interface [polypeptide binding]; other site 454166009071 putative CheW interface [polypeptide binding]; other site 454166009072 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 454166009073 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 454166009074 CHAP domain; Region: CHAP; pfam05257 454166009075 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 454166009076 putative S-transferase; Provisional; Region: PRK11752 454166009077 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 454166009078 C-terminal domain interface [polypeptide binding]; other site 454166009079 GSH binding site (G-site) [chemical binding]; other site 454166009080 dimer interface [polypeptide binding]; other site 454166009081 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 454166009082 dimer interface [polypeptide binding]; other site 454166009083 N-terminal domain interface [polypeptide binding]; other site 454166009084 active site 454166009085 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454166009086 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 454166009087 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 454166009088 putative ligand binding residues [chemical binding]; other site 454166009089 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 454166009090 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 454166009091 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 454166009092 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 454166009093 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 454166009094 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 454166009095 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 454166009096 putative substrate-binding site; other site 454166009097 nickel binding site [ion binding]; other site 454166009098 hydrogenase 2 large subunit; Provisional; Region: PRK10467 454166009099 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 454166009100 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 454166009101 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 454166009102 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 454166009103 4Fe-4S binding domain; Region: Fer4_6; pfam12837 454166009104 hydrogenase 2 small subunit; Provisional; Region: PRK10468 454166009105 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 454166009106 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 454166009107 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 454166009108 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 454166009109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166009110 dimerization interface [polypeptide binding]; other site 454166009111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166009112 dimer interface [polypeptide binding]; other site 454166009113 putative CheW interface [polypeptide binding]; other site 454166009114 hypothetical protein; Provisional; Region: PRK05208 454166009115 oxidoreductase; Provisional; Region: PRK07985 454166009116 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 454166009117 NAD binding site [chemical binding]; other site 454166009118 metal binding site [ion binding]; metal-binding site 454166009119 active site 454166009120 biopolymer transport protein ExbD; Provisional; Region: PRK11267 454166009121 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 454166009122 biopolymer transport protein ExbB; Provisional; Region: PRK10414 454166009123 cystathionine beta-lyase; Provisional; Region: PRK08114 454166009124 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 454166009125 homodimer interface [polypeptide binding]; other site 454166009126 substrate-cofactor binding pocket; other site 454166009127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166009128 catalytic residue [active] 454166009129 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454166009130 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 454166009131 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 454166009132 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 454166009133 dimer interface [polypeptide binding]; other site 454166009134 active site 454166009135 metal binding site [ion binding]; metal-binding site 454166009136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 454166009137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 454166009138 active site 454166009139 catalytic tetrad [active] 454166009140 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 454166009141 putative outer membrane lipoprotein; Provisional; Region: PRK09973 454166009142 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 454166009143 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 454166009144 active site 454166009145 hypothetical protein; Provisional; Region: PRK01254 454166009146 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 454166009147 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 454166009148 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 454166009149 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 454166009150 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 454166009151 DctM-like transporters; Region: DctM; pfam06808 454166009152 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 454166009153 FtsI repressor; Provisional; Region: PRK10883 454166009154 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 454166009155 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 454166009156 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 454166009157 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 454166009158 putative acyl-acceptor binding pocket; other site 454166009159 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 454166009160 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 454166009161 CAP-like domain; other site 454166009162 active site 454166009163 primary dimer interface [polypeptide binding]; other site 454166009164 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 454166009165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166009166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166009167 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 454166009168 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 454166009169 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 454166009170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166009171 active site 454166009172 phosphorylation site [posttranslational modification] 454166009173 intermolecular recognition site; other site 454166009174 dimerization interface [polypeptide binding]; other site 454166009175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166009176 DNA binding site [nucleotide binding] 454166009177 sensor protein QseC; Provisional; Region: PRK10337 454166009178 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 454166009179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166009180 dimer interface [polypeptide binding]; other site 454166009181 phosphorylation site [posttranslational modification] 454166009182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166009183 ATP binding site [chemical binding]; other site 454166009184 Mg2+ binding site [ion binding]; other site 454166009185 G-X-G motif; other site 454166009186 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 454166009187 Uncharacterized conserved protein [Function unknown]; Region: COG1359 454166009188 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 454166009189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166009190 ATP binding site [chemical binding]; other site 454166009191 Mg2+ binding site [ion binding]; other site 454166009192 G-X-G motif; other site 454166009193 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 454166009194 anchoring element; other site 454166009195 dimer interface [polypeptide binding]; other site 454166009196 ATP binding site [chemical binding]; other site 454166009197 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 454166009198 active site 454166009199 metal binding site [ion binding]; metal-binding site 454166009200 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 454166009201 esterase YqiA; Provisional; Region: PRK11071 454166009202 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 454166009203 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 454166009204 active site 454166009205 metal binding site [ion binding]; metal-binding site 454166009206 hexamer interface [polypeptide binding]; other site 454166009207 putative dehydrogenase; Provisional; Region: PRK11039 454166009208 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 454166009209 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 454166009210 dimer interface [polypeptide binding]; other site 454166009211 ADP-ribose binding site [chemical binding]; other site 454166009212 active site 454166009213 nudix motif; other site 454166009214 metal binding site [ion binding]; metal-binding site 454166009215 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 454166009216 hypothetical protein; Provisional; Region: PRK11653 454166009217 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 454166009218 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 454166009219 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 454166009220 putative active site [active] 454166009221 metal binding site [ion binding]; metal-binding site 454166009222 zinc transporter ZupT; Provisional; Region: PRK04201 454166009223 ZIP Zinc transporter; Region: Zip; pfam02535 454166009224 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 454166009225 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454166009226 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 454166009227 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 454166009228 catalytic residues [active] 454166009229 hinge region; other site 454166009230 alpha helical domain; other site 454166009231 putative disulfide oxidoreductase; Provisional; Region: PRK04307 454166009232 Integrase core domain; Region: rve; pfam00665 454166009233 Integrase core domain; Region: rve_3; pfam13683 454166009234 Helix-turn-helix domain; Region: HTH_28; pfam13518 454166009235 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 454166009236 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 454166009237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 454166009238 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 454166009239 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 454166009240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 454166009241 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 454166009242 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 454166009243 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 454166009244 putative ribose interaction site [chemical binding]; other site 454166009245 putative ADP binding site [chemical binding]; other site 454166009246 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 454166009247 active site 454166009248 nucleotide binding site [chemical binding]; other site 454166009249 HIGH motif; other site 454166009250 KMSKS motif; other site 454166009251 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 454166009252 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 454166009253 metal binding triad; other site 454166009254 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 454166009255 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 454166009256 metal binding triad; other site 454166009257 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 454166009258 Uncharacterized conserved protein [Function unknown]; Region: COG3025 454166009259 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 454166009260 putative active site [active] 454166009261 putative metal binding residues [ion binding]; other site 454166009262 signature motif; other site 454166009263 putative triphosphate binding site [ion binding]; other site 454166009264 CHAD domain; Region: CHAD; pfam05235 454166009265 SH3 domain-containing protein; Provisional; Region: PRK10884 454166009266 Bacterial SH3 domain homologues; Region: SH3b; smart00287 454166009267 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 454166009268 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 454166009269 active site 454166009270 NTP binding site [chemical binding]; other site 454166009271 metal binding triad [ion binding]; metal-binding site 454166009272 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 454166009273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454166009274 Zn2+ binding site [ion binding]; other site 454166009275 Mg2+ binding site [ion binding]; other site 454166009276 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 454166009277 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 454166009278 homooctamer interface [polypeptide binding]; other site 454166009279 active site 454166009280 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 454166009281 UGMP family protein; Validated; Region: PRK09604 454166009282 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 454166009283 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 454166009284 DNA primase; Validated; Region: dnaG; PRK05667 454166009285 CHC2 zinc finger; Region: zf-CHC2; pfam01807 454166009286 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 454166009287 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 454166009288 active site 454166009289 metal binding site [ion binding]; metal-binding site 454166009290 interdomain interaction site; other site 454166009291 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 454166009292 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 454166009293 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 454166009294 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 454166009295 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 454166009296 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 454166009297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454166009298 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 454166009299 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454166009300 DNA binding residues [nucleotide binding] 454166009301 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 454166009302 active site 454166009303 SUMO-1 interface [polypeptide binding]; other site 454166009304 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 454166009305 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 454166009306 FAD binding pocket [chemical binding]; other site 454166009307 FAD binding motif [chemical binding]; other site 454166009308 phosphate binding motif [ion binding]; other site 454166009309 NAD binding pocket [chemical binding]; other site 454166009310 Predicted transcriptional regulators [Transcription]; Region: COG1695 454166009311 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 454166009312 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 454166009313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166009314 dimerization interface [polypeptide binding]; other site 454166009315 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 454166009316 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166009317 dimer interface [polypeptide binding]; other site 454166009318 putative CheW interface [polypeptide binding]; other site 454166009319 PAS fold; Region: PAS_3; pfam08447 454166009320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166009321 putative active site [active] 454166009322 heme pocket [chemical binding]; other site 454166009323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 454166009324 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 454166009325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166009326 dimer interface [polypeptide binding]; other site 454166009327 putative CheW interface [polypeptide binding]; other site 454166009328 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 454166009329 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454166009330 inhibitor-cofactor binding pocket; inhibition site 454166009331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166009332 catalytic residue [active] 454166009333 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 454166009334 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 454166009335 active site 454166009336 FMN binding site [chemical binding]; other site 454166009337 2,4-decadienoyl-CoA binding site; other site 454166009338 catalytic residue [active] 454166009339 4Fe-4S cluster binding site [ion binding]; other site 454166009340 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 454166009341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454166009342 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 454166009343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166009344 S-adenosylmethionine binding site [chemical binding]; other site 454166009345 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 454166009346 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 454166009347 putative active site [active] 454166009348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454166009349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454166009350 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 454166009351 serine/threonine transporter SstT; Provisional; Region: PRK13628 454166009352 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454166009353 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 454166009354 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 454166009355 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 454166009356 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 454166009357 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 454166009358 Predicted membrane protein [Function unknown]; Region: COG5393 454166009359 YqjK-like protein; Region: YqjK; pfam13997 454166009360 Predicted membrane protein [Function unknown]; Region: COG2259 454166009361 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 454166009362 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 454166009363 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 454166009364 putative dimer interface [polypeptide binding]; other site 454166009365 N-terminal domain interface [polypeptide binding]; other site 454166009366 putative substrate binding pocket (H-site) [chemical binding]; other site 454166009367 Predicted membrane protein [Function unknown]; Region: COG3152 454166009368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166009369 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 454166009370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 454166009371 dimerization interface [polypeptide binding]; other site 454166009372 Pirin-related protein [General function prediction only]; Region: COG1741 454166009373 Pirin; Region: Pirin; pfam02678 454166009374 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 454166009375 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454166009376 serine transporter; Region: stp; TIGR00814 454166009377 L-serine dehydratase TdcG; Provisional; Region: PRK15040 454166009378 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 454166009379 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 454166009380 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 454166009381 Pyruvate formate lyase 1; Region: PFL1; cd01678 454166009382 coenzyme A binding site [chemical binding]; other site 454166009383 active site 454166009384 catalytic residues [active] 454166009385 glycine loop; other site 454166009386 propionate/acetate kinase; Provisional; Region: PRK12379 454166009387 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 454166009388 threonine/serine transporter TdcC; Provisional; Region: PRK13629 454166009389 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454166009390 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 454166009391 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 454166009392 tetramer interface [polypeptide binding]; other site 454166009393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166009394 catalytic residue [active] 454166009395 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 454166009396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166009397 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 454166009398 putative substrate binding pocket [chemical binding]; other site 454166009399 putative dimerization interface [polypeptide binding]; other site 454166009400 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 454166009401 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454166009402 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 454166009403 galactarate dehydratase; Region: galactar-dH20; TIGR03248 454166009404 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 454166009405 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 454166009406 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 454166009407 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 454166009408 intersubunit interface [polypeptide binding]; other site 454166009409 active site 454166009410 zinc binding site [ion binding]; other site 454166009411 Na+ binding site [ion binding]; other site 454166009412 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 454166009413 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166009414 active site 454166009415 phosphorylation site [posttranslational modification] 454166009416 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 454166009417 active site 454166009418 P-loop; other site 454166009419 phosphorylation site [posttranslational modification] 454166009420 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454166009421 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 454166009422 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 454166009423 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 454166009424 putative NAD(P) binding site [chemical binding]; other site 454166009425 catalytic Zn binding site [ion binding]; other site 454166009426 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166009427 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454166009428 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166009429 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 454166009430 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 454166009431 putative SAM binding site [chemical binding]; other site 454166009432 putative homodimer interface [polypeptide binding]; other site 454166009433 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 454166009434 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 454166009435 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 454166009436 putative ligand binding site [chemical binding]; other site 454166009437 TIGR00252 family protein; Region: TIGR00252 454166009438 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 454166009439 dimer interface [polypeptide binding]; other site 454166009440 active site 454166009441 outer membrane lipoprotein; Provisional; Region: PRK11023 454166009442 BON domain; Region: BON; pfam04972 454166009443 BON domain; Region: BON; pfam04972 454166009444 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 454166009445 NADH(P)-binding; Region: NAD_binding_10; pfam13460 454166009446 NAD binding site [chemical binding]; other site 454166009447 active site 454166009448 intracellular protease, PfpI family; Region: PfpI; TIGR01382 454166009449 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 454166009450 proposed catalytic triad [active] 454166009451 conserved cys residue [active] 454166009452 hypothetical protein; Provisional; Region: PRK03467 454166009453 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 454166009454 GIY-YIG motif/motif A; other site 454166009455 putative active site [active] 454166009456 putative metal binding site [ion binding]; other site 454166009457 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 454166009458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166009459 Coenzyme A binding pocket [chemical binding]; other site 454166009460 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 454166009461 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 454166009462 Peptidase family U32; Region: Peptidase_U32; pfam01136 454166009463 putative protease; Provisional; Region: PRK15447 454166009464 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 454166009465 hypothetical protein; Provisional; Region: PRK10508 454166009466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 454166009467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 454166009468 tryptophan permease; Provisional; Region: PRK10483 454166009469 aromatic amino acid transport protein; Region: araaP; TIGR00837 454166009470 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454166009471 DEAD-like helicases superfamily; Region: DEXDc; smart00487 454166009472 ATP binding site [chemical binding]; other site 454166009473 Mg++ binding site [ion binding]; other site 454166009474 motif III; other site 454166009475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166009476 nucleotide binding region [chemical binding]; other site 454166009477 ATP-binding site [chemical binding]; other site 454166009478 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 454166009479 putative RNA binding site [nucleotide binding]; other site 454166009480 lipoprotein NlpI; Provisional; Region: PRK11189 454166009481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166009482 binding surface 454166009483 TPR motif; other site 454166009484 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 454166009485 16S/18S rRNA binding site [nucleotide binding]; other site 454166009486 S13e-L30e interaction site [polypeptide binding]; other site 454166009487 25S rRNA binding site [nucleotide binding]; other site 454166009488 Ribosomal S15 leader 454166009489 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 454166009490 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 454166009491 RNA binding site [nucleotide binding]; other site 454166009492 active site 454166009493 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 454166009494 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 454166009495 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 454166009496 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 454166009497 translation initiation factor IF-2; Region: IF-2; TIGR00487 454166009498 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 454166009499 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 454166009500 G1 box; other site 454166009501 putative GEF interaction site [polypeptide binding]; other site 454166009502 GTP/Mg2+ binding site [chemical binding]; other site 454166009503 Switch I region; other site 454166009504 G2 box; other site 454166009505 G3 box; other site 454166009506 Switch II region; other site 454166009507 G4 box; other site 454166009508 G5 box; other site 454166009509 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 454166009510 Translation-initiation factor 2; Region: IF-2; pfam11987 454166009511 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 454166009512 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 454166009513 NusA N-terminal domain; Region: NusA_N; pfam08529 454166009514 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 454166009515 RNA binding site [nucleotide binding]; other site 454166009516 homodimer interface [polypeptide binding]; other site 454166009517 NusA-like KH domain; Region: KH_5; pfam13184 454166009518 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 454166009519 G-X-X-G motif; other site 454166009520 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 454166009521 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 454166009522 ribosome maturation protein RimP; Reviewed; Region: PRK00092 454166009523 Sm and related proteins; Region: Sm_like; cl00259 454166009524 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 454166009525 putative oligomer interface [polypeptide binding]; other site 454166009526 putative RNA binding site [nucleotide binding]; other site 454166009527 argininosuccinate synthase; Validated; Region: PRK05370 454166009528 argininosuccinate synthase; Provisional; Region: PRK13820 454166009529 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 454166009530 Preprotein translocase SecG subunit; Region: SecG; pfam03840 454166009531 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 454166009532 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 454166009533 active site 454166009534 substrate binding site [chemical binding]; other site 454166009535 metal binding site [ion binding]; metal-binding site 454166009536 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 454166009537 dihydropteroate synthase; Region: DHPS; TIGR01496 454166009538 substrate binding pocket [chemical binding]; other site 454166009539 dimer interface [polypeptide binding]; other site 454166009540 inhibitor binding site; inhibition site 454166009541 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 454166009542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166009543 Walker A motif; other site 454166009544 ATP binding site [chemical binding]; other site 454166009545 Walker B motif; other site 454166009546 arginine finger; other site 454166009547 Peptidase family M41; Region: Peptidase_M41; pfam01434 454166009548 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 454166009549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166009550 S-adenosylmethionine binding site [chemical binding]; other site 454166009551 RNA-binding protein YhbY; Provisional; Region: PRK10343 454166009552 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 454166009553 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 454166009554 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 454166009555 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 454166009556 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 454166009557 GTPase CgtA; Reviewed; Region: obgE; PRK12298 454166009558 GTP1/OBG; Region: GTP1_OBG; pfam01018 454166009559 Obg GTPase; Region: Obg; cd01898 454166009560 G1 box; other site 454166009561 GTP/Mg2+ binding site [chemical binding]; other site 454166009562 Switch I region; other site 454166009563 G2 box; other site 454166009564 G3 box; other site 454166009565 Switch II region; other site 454166009566 G4 box; other site 454166009567 G5 box; other site 454166009568 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 454166009569 EamA-like transporter family; Region: EamA; pfam00892 454166009570 EamA-like transporter family; Region: EamA; pfam00892 454166009571 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 454166009572 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 454166009573 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 454166009574 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 454166009575 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 454166009576 substrate binding pocket [chemical binding]; other site 454166009577 chain length determination region; other site 454166009578 substrate-Mg2+ binding site; other site 454166009579 catalytic residues [active] 454166009580 aspartate-rich region 1; other site 454166009581 active site lid residues [active] 454166009582 aspartate-rich region 2; other site 454166009583 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 454166009584 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 454166009585 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 454166009586 hinge; other site 454166009587 active site 454166009588 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 454166009589 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 454166009590 anti sigma factor interaction site; other site 454166009591 regulatory phosphorylation site [posttranslational modification]; other site 454166009592 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 454166009593 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 454166009594 mce related protein; Region: MCE; pfam02470 454166009595 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 454166009596 conserved hypothetical integral membrane protein; Region: TIGR00056 454166009597 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 454166009598 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 454166009599 Walker A/P-loop; other site 454166009600 ATP binding site [chemical binding]; other site 454166009601 Q-loop/lid; other site 454166009602 ABC transporter signature motif; other site 454166009603 Walker B; other site 454166009604 D-loop; other site 454166009605 H-loop/switch region; other site 454166009606 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 454166009607 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 454166009608 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 454166009609 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 454166009610 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 454166009611 putative active site [active] 454166009612 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 454166009613 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 454166009614 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 454166009615 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 454166009616 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 454166009617 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 454166009618 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 454166009619 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 454166009620 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 454166009621 Walker A/P-loop; other site 454166009622 ATP binding site [chemical binding]; other site 454166009623 Q-loop/lid; other site 454166009624 ABC transporter signature motif; other site 454166009625 Walker B; other site 454166009626 D-loop; other site 454166009627 H-loop/switch region; other site 454166009628 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 454166009629 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 454166009630 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 454166009631 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 454166009632 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 454166009633 30S subunit binding site; other site 454166009634 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166009635 active site 454166009636 phosphorylation site [posttranslational modification] 454166009637 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 454166009638 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454166009639 dimerization domain swap beta strand [polypeptide binding]; other site 454166009640 regulatory protein interface [polypeptide binding]; other site 454166009641 active site 454166009642 regulatory phosphorylation site [posttranslational modification]; other site 454166009643 hypothetical protein; Provisional; Region: PRK10345 454166009644 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 454166009645 Transglycosylase; Region: Transgly; cl17702 454166009646 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 454166009647 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 454166009648 conserved cys residue [active] 454166009649 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 454166009650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166009651 putative active site [active] 454166009652 heme pocket [chemical binding]; other site 454166009653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166009654 dimer interface [polypeptide binding]; other site 454166009655 phosphorylation site [posttranslational modification] 454166009656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166009657 ATP binding site [chemical binding]; other site 454166009658 Mg2+ binding site [ion binding]; other site 454166009659 G-X-G motif; other site 454166009660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166009661 active site 454166009662 phosphorylation site [posttranslational modification] 454166009663 intermolecular recognition site; other site 454166009664 dimerization interface [polypeptide binding]; other site 454166009665 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454166009666 putative binding surface; other site 454166009667 active site 454166009668 radical SAM protein, TIGR01212 family; Region: TIGR01212 454166009669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166009670 FeS/SAM binding site; other site 454166009671 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 454166009672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454166009673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166009674 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 454166009675 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 454166009676 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 454166009677 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 454166009678 Na binding site [ion binding]; other site 454166009679 putative substrate binding site [chemical binding]; other site 454166009680 cytosine deaminase; Provisional; Region: PRK09230 454166009681 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 454166009682 active site 454166009683 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454166009684 N-acetylmannosamine kinase; Provisional; Region: PRK05082 454166009685 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166009686 nucleotide binding site [chemical binding]; other site 454166009687 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 454166009688 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 454166009689 putative active site cavity [active] 454166009690 putative sialic acid transporter; Provisional; Region: PRK03893 454166009691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166009692 putative substrate translocation pore; other site 454166009693 N-acetylneuraminate lyase; Provisional; Region: PRK04147 454166009694 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 454166009695 inhibitor site; inhibition site 454166009696 active site 454166009697 dimer interface [polypeptide binding]; other site 454166009698 catalytic residue [active] 454166009699 transcriptional regulator NanR; Provisional; Region: PRK03837 454166009700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166009701 DNA-binding site [nucleotide binding]; DNA binding site 454166009702 FCD domain; Region: FCD; pfam07729 454166009703 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 454166009704 stringent starvation protein A; Provisional; Region: sspA; PRK09481 454166009705 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 454166009706 C-terminal domain interface [polypeptide binding]; other site 454166009707 putative GSH binding site (G-site) [chemical binding]; other site 454166009708 dimer interface [polypeptide binding]; other site 454166009709 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 454166009710 dimer interface [polypeptide binding]; other site 454166009711 N-terminal domain interface [polypeptide binding]; other site 454166009712 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 454166009713 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 454166009714 23S rRNA interface [nucleotide binding]; other site 454166009715 L3 interface [polypeptide binding]; other site 454166009716 Predicted ATPase [General function prediction only]; Region: COG1485 454166009717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 454166009718 hypothetical protein; Provisional; Region: PRK11677 454166009719 serine endoprotease; Provisional; Region: PRK10139 454166009720 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 454166009721 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454166009722 protein binding site [polypeptide binding]; other site 454166009723 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454166009724 serine endoprotease; Provisional; Region: PRK10898 454166009725 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 454166009726 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 454166009727 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 454166009728 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 454166009729 oxaloacetate decarboxylase; Provisional; Region: PRK14040 454166009730 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 454166009731 active site 454166009732 catalytic residues [active] 454166009733 metal binding site [ion binding]; metal-binding site 454166009734 homodimer binding site [polypeptide binding]; other site 454166009735 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454166009736 carboxyltransferase (CT) interaction site; other site 454166009737 biotinylation site [posttranslational modification]; other site 454166009738 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 454166009739 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 454166009740 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 454166009741 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 454166009742 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 454166009743 transmembrane helices; other site 454166009744 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454166009745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166009746 DNA-binding site [nucleotide binding]; DNA binding site 454166009747 FCD domain; Region: FCD; pfam07729 454166009748 Transcriptional regulators [Transcription]; Region: GntR; COG1802 454166009749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166009750 DNA-binding site [nucleotide binding]; DNA binding site 454166009751 malate dehydrogenase; Provisional; Region: PRK05086 454166009752 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 454166009753 NAD binding site [chemical binding]; other site 454166009754 dimerization interface [polypeptide binding]; other site 454166009755 Substrate binding site [chemical binding]; other site 454166009756 arginine repressor; Provisional; Region: PRK05066 454166009757 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 454166009758 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 454166009759 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166009760 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166009761 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 454166009762 RNAase interaction site [polypeptide binding]; other site 454166009763 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 454166009764 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454166009765 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 454166009766 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166009767 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166009768 efflux system membrane protein; Provisional; Region: PRK11594 454166009769 transcriptional regulator; Provisional; Region: PRK10632 454166009770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166009771 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 454166009772 putative effector binding pocket; other site 454166009773 dimerization interface [polypeptide binding]; other site 454166009774 protease TldD; Provisional; Region: tldD; PRK10735 454166009775 hypothetical protein; Provisional; Region: PRK10899 454166009776 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 454166009777 ribonuclease G; Provisional; Region: PRK11712 454166009778 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 454166009779 homodimer interface [polypeptide binding]; other site 454166009780 oligonucleotide binding site [chemical binding]; other site 454166009781 Maf-like protein; Region: Maf; pfam02545 454166009782 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 454166009783 active site 454166009784 dimer interface [polypeptide binding]; other site 454166009785 rod shape-determining protein MreD; Provisional; Region: PRK11060 454166009786 rod shape-determining protein MreC; Region: mreC; TIGR00219 454166009787 rod shape-determining protein MreC; Region: MreC; pfam04085 454166009788 rod shape-determining protein MreB; Provisional; Region: PRK13927 454166009789 MreB and similar proteins; Region: MreB_like; cd10225 454166009790 nucleotide binding site [chemical binding]; other site 454166009791 Mg binding site [ion binding]; other site 454166009792 putative protofilament interaction site [polypeptide binding]; other site 454166009793 RodZ interaction site [polypeptide binding]; other site 454166009794 regulatory protein CsrD; Provisional; Region: PRK11059 454166009795 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166009796 metal binding site [ion binding]; metal-binding site 454166009797 active site 454166009798 I-site; other site 454166009799 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166009800 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 454166009801 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 454166009802 NADP binding site [chemical binding]; other site 454166009803 dimer interface [polypeptide binding]; other site 454166009804 TMAO/DMSO reductase; Reviewed; Region: PRK05363 454166009805 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 454166009806 Moco binding site; other site 454166009807 metal coordination site [ion binding]; other site 454166009808 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 454166009809 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 454166009810 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 454166009811 carboxyltransferase (CT) interaction site; other site 454166009812 biotinylation site [posttranslational modification]; other site 454166009813 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 454166009814 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 454166009815 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 454166009816 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 454166009817 hypothetical protein; Provisional; Region: PRK10633 454166009818 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 454166009819 Na binding site [ion binding]; other site 454166009820 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 454166009821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 454166009822 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 454166009823 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 454166009824 FMN binding site [chemical binding]; other site 454166009825 active site 454166009826 catalytic residues [active] 454166009827 substrate binding site [chemical binding]; other site 454166009828 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 454166009829 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 454166009830 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 454166009831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166009832 DNA methylase; Region: N6_N4_Mtase; pfam01555 454166009833 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 454166009834 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 454166009835 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 454166009836 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 454166009837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166009838 metal binding site [ion binding]; metal-binding site 454166009839 active site 454166009840 I-site; other site 454166009841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166009842 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 454166009843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166009844 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 454166009845 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 454166009846 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166009847 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166009848 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 454166009849 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 454166009850 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 454166009851 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 454166009852 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 454166009853 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 454166009854 shikimate binding site; other site 454166009855 NAD(P) binding site [chemical binding]; other site 454166009856 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 454166009857 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454166009858 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 454166009859 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454166009860 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 454166009861 hypothetical protein; Validated; Region: PRK03430 454166009862 hypothetical protein; Provisional; Region: PRK10736 454166009863 DNA protecting protein DprA; Region: dprA; TIGR00732 454166009864 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 454166009865 active site 454166009866 catalytic residues [active] 454166009867 metal binding site [ion binding]; metal-binding site 454166009868 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 454166009869 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 454166009870 putative active site [active] 454166009871 substrate binding site [chemical binding]; other site 454166009872 putative cosubstrate binding site; other site 454166009873 catalytic site [active] 454166009874 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 454166009875 substrate binding site [chemical binding]; other site 454166009876 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 454166009877 putative RNA binding site [nucleotide binding]; other site 454166009878 16S rRNA methyltransferase B; Provisional; Region: PRK10901 454166009879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166009880 S-adenosylmethionine binding site [chemical binding]; other site 454166009881 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 454166009882 TrkA-N domain; Region: TrkA_N; pfam02254 454166009883 TrkA-C domain; Region: TrkA_C; pfam02080 454166009884 TrkA-N domain; Region: TrkA_N; pfam02254 454166009885 TrkA-C domain; Region: TrkA_C; pfam02080 454166009886 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 454166009887 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 454166009888 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 454166009889 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 454166009890 DNA binding residues [nucleotide binding] 454166009891 dimer interface [polypeptide binding]; other site 454166009892 metal binding site [ion binding]; metal-binding site 454166009893 hypothetical protein; Provisional; Region: PRK10203 454166009894 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 454166009895 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 454166009896 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 454166009897 alphaNTD homodimer interface [polypeptide binding]; other site 454166009898 alphaNTD - beta interaction site [polypeptide binding]; other site 454166009899 alphaNTD - beta' interaction site [polypeptide binding]; other site 454166009900 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 454166009901 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 454166009902 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 454166009903 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166009904 RNA binding surface [nucleotide binding]; other site 454166009905 30S ribosomal protein S11; Validated; Region: PRK05309 454166009906 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 454166009907 30S ribosomal protein S13; Region: bact_S13; TIGR03631 454166009908 Alpha operon ribosome binding site 454166009909 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 454166009910 SecY translocase; Region: SecY; pfam00344 454166009911 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 454166009912 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 454166009913 23S rRNA binding site [nucleotide binding]; other site 454166009914 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 454166009915 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 454166009916 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 454166009917 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 454166009918 23S rRNA interface [nucleotide binding]; other site 454166009919 5S rRNA interface [nucleotide binding]; other site 454166009920 L27 interface [polypeptide binding]; other site 454166009921 L5 interface [polypeptide binding]; other site 454166009922 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 454166009923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 454166009924 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 454166009925 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 454166009926 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 454166009927 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 454166009928 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 454166009929 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 454166009930 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 454166009931 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 454166009932 RNA binding site [nucleotide binding]; other site 454166009933 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 454166009934 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 454166009935 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 454166009936 23S rRNA interface [nucleotide binding]; other site 454166009937 putative translocon interaction site; other site 454166009938 signal recognition particle (SRP54) interaction site; other site 454166009939 L23 interface [polypeptide binding]; other site 454166009940 trigger factor interaction site; other site 454166009941 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 454166009942 23S rRNA interface [nucleotide binding]; other site 454166009943 5S rRNA interface [nucleotide binding]; other site 454166009944 putative antibiotic binding site [chemical binding]; other site 454166009945 L25 interface [polypeptide binding]; other site 454166009946 L27 interface [polypeptide binding]; other site 454166009947 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 454166009948 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 454166009949 G-X-X-G motif; other site 454166009950 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 454166009951 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 454166009952 protein-rRNA interface [nucleotide binding]; other site 454166009953 putative translocon binding site; other site 454166009954 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 454166009955 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 454166009956 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 454166009957 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 454166009958 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 454166009959 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 454166009960 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 454166009961 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 454166009962 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 454166009963 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 454166009964 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 454166009965 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 454166009966 heme binding site [chemical binding]; other site 454166009967 ferroxidase pore; other site 454166009968 ferroxidase diiron center [ion binding]; other site 454166009969 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 454166009970 elongation factor Tu; Reviewed; Region: PRK00049 454166009971 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 454166009972 G1 box; other site 454166009973 GEF interaction site [polypeptide binding]; other site 454166009974 GTP/Mg2+ binding site [chemical binding]; other site 454166009975 Switch I region; other site 454166009976 G2 box; other site 454166009977 G3 box; other site 454166009978 Switch II region; other site 454166009979 G4 box; other site 454166009980 G5 box; other site 454166009981 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 454166009982 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 454166009983 Antibiotic Binding Site [chemical binding]; other site 454166009984 elongation factor G; Reviewed; Region: PRK00007 454166009985 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 454166009986 G1 box; other site 454166009987 putative GEF interaction site [polypeptide binding]; other site 454166009988 GTP/Mg2+ binding site [chemical binding]; other site 454166009989 Switch I region; other site 454166009990 G2 box; other site 454166009991 G3 box; other site 454166009992 Switch II region; other site 454166009993 G4 box; other site 454166009994 G5 box; other site 454166009995 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 454166009996 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 454166009997 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 454166009998 30S ribosomal protein S7; Validated; Region: PRK05302 454166009999 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 454166010000 S17 interaction site [polypeptide binding]; other site 454166010001 S8 interaction site; other site 454166010002 16S rRNA interaction site [nucleotide binding]; other site 454166010003 streptomycin interaction site [chemical binding]; other site 454166010004 23S rRNA interaction site [nucleotide binding]; other site 454166010005 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 454166010006 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 454166010007 sulfur relay protein TusC; Validated; Region: PRK00211 454166010008 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 454166010009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 454166010010 YheO-like PAS domain; Region: PAS_6; pfam08348 454166010011 HTH domain; Region: HTH_22; pfam13309 454166010012 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 454166010013 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 454166010014 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454166010015 phi X174 lysis protein; Provisional; Region: PRK02793 454166010016 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 454166010017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454166010018 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 454166010019 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 454166010020 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 454166010021 TrkA-N domain; Region: TrkA_N; pfam02254 454166010022 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 454166010023 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 454166010024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166010025 Walker A/P-loop; other site 454166010026 ATP binding site [chemical binding]; other site 454166010027 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166010028 ABC transporter signature motif; other site 454166010029 Walker B; other site 454166010030 D-loop; other site 454166010031 ABC transporter; Region: ABC_tran_2; pfam12848 454166010032 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166010033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166010034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166010035 putative monooxygenase; Provisional; Region: PRK11118 454166010036 putative hydrolase; Provisional; Region: PRK10985 454166010037 hypothetical protein; Provisional; Region: PRK04966 454166010038 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 454166010039 active site 454166010040 hypothetical protein; Provisional; Region: PRK10738 454166010041 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 454166010042 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 454166010043 ligand binding site [chemical binding]; other site 454166010044 flexible hinge region; other site 454166010045 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 454166010046 putative switch regulator; other site 454166010047 non-specific DNA interactions [nucleotide binding]; other site 454166010048 DNA binding site [nucleotide binding] 454166010049 sequence specific DNA binding site [nucleotide binding]; other site 454166010050 putative cAMP binding site [chemical binding]; other site 454166010051 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 454166010052 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 454166010053 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 454166010054 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 454166010055 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 454166010056 inhibitor-cofactor binding pocket; inhibition site 454166010057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166010058 catalytic residue [active] 454166010059 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 454166010060 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 454166010061 glutamine binding [chemical binding]; other site 454166010062 catalytic triad [active] 454166010063 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 454166010064 cell filamentation protein Fic; Provisional; Region: PRK10347 454166010065 hypothetical protein; Provisional; Region: PRK10204 454166010066 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 454166010067 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 454166010068 substrate binding site [chemical binding]; other site 454166010069 putative transporter; Provisional; Region: PRK03699 454166010070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166010071 putative substrate translocation pore; other site 454166010072 nitrite reductase subunit NirD; Provisional; Region: PRK14989 454166010073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166010074 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 454166010075 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 454166010076 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 454166010077 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 454166010078 nitrite transporter NirC; Provisional; Region: PRK11562 454166010079 siroheme synthase; Provisional; Region: cysG; PRK10637 454166010080 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 454166010081 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 454166010082 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 454166010083 active site 454166010084 SAM binding site [chemical binding]; other site 454166010085 homodimer interface [polypeptide binding]; other site 454166010086 Integrase core domain; Region: rve; pfam00665 454166010087 Integrase core domain; Region: rve_3; pfam13683 454166010088 Helix-turn-helix domain; Region: HTH_28; pfam13518 454166010089 hypothetical protein; Provisional; Region: PRK09946 454166010090 Autotransporter beta-domain; Region: Autotransporter; pfam03797 454166010091 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 454166010092 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 454166010093 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 454166010094 active site 454166010095 HIGH motif; other site 454166010096 dimer interface [polypeptide binding]; other site 454166010097 KMSKS motif; other site 454166010098 phosphoglycolate phosphatase; Provisional; Region: PRK13222 454166010099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166010100 motif II; other site 454166010101 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454166010102 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 454166010103 substrate binding site [chemical binding]; other site 454166010104 hexamer interface [polypeptide binding]; other site 454166010105 metal binding site [ion binding]; metal-binding site 454166010106 DNA adenine methylase; Provisional; Region: PRK10904 454166010107 cell division protein DamX; Validated; Region: PRK10905 454166010108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 454166010109 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 454166010110 active site 454166010111 dimer interface [polypeptide binding]; other site 454166010112 metal binding site [ion binding]; metal-binding site 454166010113 shikimate kinase; Reviewed; Region: aroK; PRK00131 454166010114 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 454166010115 ADP binding site [chemical binding]; other site 454166010116 magnesium binding site [ion binding]; other site 454166010117 putative shikimate binding site; other site 454166010118 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 454166010119 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 454166010120 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 454166010121 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 454166010122 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 454166010123 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 454166010124 Transglycosylase; Region: Transgly; pfam00912 454166010125 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 454166010126 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 454166010127 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 454166010128 ADP-ribose binding site [chemical binding]; other site 454166010129 dimer interface [polypeptide binding]; other site 454166010130 active site 454166010131 nudix motif; other site 454166010132 metal binding site [ion binding]; metal-binding site 454166010133 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 454166010134 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 454166010135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166010136 motif II; other site 454166010137 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166010138 RNA binding surface [nucleotide binding]; other site 454166010139 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 454166010140 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 454166010141 dimerization interface [polypeptide binding]; other site 454166010142 domain crossover interface; other site 454166010143 redox-dependent activation switch; other site 454166010144 Transposase; Region: DEDD_Tnp_IS110; pfam01548 454166010145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 454166010146 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 454166010147 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 454166010148 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 454166010149 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 454166010150 active site 454166010151 substrate-binding site [chemical binding]; other site 454166010152 metal-binding site [ion binding] 454166010153 ATP binding site [chemical binding]; other site 454166010154 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 454166010155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166010156 dimerization interface [polypeptide binding]; other site 454166010157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166010158 dimer interface [polypeptide binding]; other site 454166010159 phosphorylation site [posttranslational modification] 454166010160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166010161 ATP binding site [chemical binding]; other site 454166010162 G-X-G motif; other site 454166010163 osmolarity response regulator; Provisional; Region: ompR; PRK09468 454166010164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166010165 active site 454166010166 phosphorylation site [posttranslational modification] 454166010167 intermolecular recognition site; other site 454166010168 dimerization interface [polypeptide binding]; other site 454166010169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166010170 DNA binding site [nucleotide binding] 454166010171 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 454166010172 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 454166010173 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 454166010174 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 454166010175 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 454166010176 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 454166010177 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 454166010178 RNA binding site [nucleotide binding]; other site 454166010179 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 454166010180 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 454166010181 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 454166010182 G1 box; other site 454166010183 GTP/Mg2+ binding site [chemical binding]; other site 454166010184 Switch I region; other site 454166010185 G2 box; other site 454166010186 G3 box; other site 454166010187 Switch II region; other site 454166010188 G4 box; other site 454166010189 G5 box; other site 454166010190 Nucleoside recognition; Region: Gate; pfam07670 454166010191 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 454166010192 Nucleoside recognition; Region: Gate; pfam07670 454166010193 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 454166010194 hypothetical protein; Provisional; Region: PRK09956 454166010195 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454166010196 carboxylesterase BioH; Provisional; Region: PRK10349 454166010197 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 454166010198 DNA utilization protein GntX; Provisional; Region: PRK11595 454166010199 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166010200 active site 454166010201 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 454166010202 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 454166010203 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 454166010204 high-affinity gluconate transporter; Provisional; Region: PRK14984 454166010205 gluconate transporter; Region: gntP; TIGR00791 454166010206 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 454166010207 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 454166010208 maltodextrin phosphorylase; Provisional; Region: PRK14985 454166010209 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 454166010210 homodimer interface [polypeptide binding]; other site 454166010211 active site pocket [active] 454166010212 transcriptional regulator MalT; Provisional; Region: PRK04841 454166010213 AAA ATPase domain; Region: AAA_16; pfam13191 454166010214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166010215 DNA binding residues [nucleotide binding] 454166010216 dimerization interface [polypeptide binding]; other site 454166010217 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 454166010218 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 454166010219 putative active site [active] 454166010220 adenylation catalytic residue [active] 454166010221 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 454166010222 hypothetical protein; Reviewed; Region: PRK09588 454166010223 TROVE domain; Region: TROVE; pfam05731 454166010224 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 454166010225 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 454166010226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166010227 Walker A motif; other site 454166010228 ATP binding site [chemical binding]; other site 454166010229 Walker B motif; other site 454166010230 arginine finger; other site 454166010231 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 454166010232 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454166010233 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166010234 intramembrane serine protease GlpG; Provisional; Region: PRK10907 454166010235 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 454166010236 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 454166010237 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 454166010238 active site residue [active] 454166010239 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 454166010240 hypothetical protein; Provisional; Region: PRK09781 454166010241 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 454166010242 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 454166010243 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 454166010244 dimer interface [polypeptide binding]; other site 454166010245 active site 454166010246 metal binding site [ion binding]; metal-binding site 454166010247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166010248 D-galactonate transporter; Region: 2A0114; TIGR00893 454166010249 putative substrate translocation pore; other site 454166010250 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 454166010251 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 454166010252 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 454166010253 inhibitor site; inhibition site 454166010254 active site 454166010255 dimer interface [polypeptide binding]; other site 454166010256 catalytic residue [active] 454166010257 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454166010258 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454166010259 Bacterial transcriptional regulator; Region: IclR; pfam01614 454166010260 glycogen phosphorylase; Provisional; Region: PRK14986 454166010261 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 454166010262 homodimer interface [polypeptide binding]; other site 454166010263 active site pocket [active] 454166010264 glycogen synthase; Provisional; Region: glgA; PRK00654 454166010265 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 454166010266 ADP-binding pocket [chemical binding]; other site 454166010267 homodimer interface [polypeptide binding]; other site 454166010268 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 454166010269 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 454166010270 ligand binding site; other site 454166010271 oligomer interface; other site 454166010272 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 454166010273 dimer interface [polypeptide binding]; other site 454166010274 N-terminal domain interface [polypeptide binding]; other site 454166010275 sulfate 1 binding site; other site 454166010276 glycogen debranching enzyme; Provisional; Region: PRK03705 454166010277 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 454166010278 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 454166010279 active site 454166010280 catalytic site [active] 454166010281 glycogen branching enzyme; Provisional; Region: PRK05402 454166010282 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 454166010283 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 454166010284 active site 454166010285 catalytic site [active] 454166010286 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 454166010287 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 454166010288 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 454166010289 low affinity gluconate transporter; Provisional; Region: PRK10472 454166010290 gluconate transporter; Region: gntP; TIGR00791 454166010291 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 454166010292 ATP-binding site [chemical binding]; other site 454166010293 Gluconate-6-phosphate binding site [chemical binding]; other site 454166010294 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 454166010295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166010296 DNA binding site [nucleotide binding] 454166010297 domain linker motif; other site 454166010298 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454166010299 putative ligand binding site [chemical binding]; other site 454166010300 putative dimerization interface [polypeptide binding]; other site 454166010301 Pirin-related protein [General function prediction only]; Region: COG1741 454166010302 Pirin; Region: Pirin; pfam02678 454166010303 putative oxidoreductase; Provisional; Region: PRK10206 454166010304 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454166010305 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454166010306 putative acetyltransferase YhhY; Provisional; Region: PRK10140 454166010307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166010308 Coenzyme A binding pocket [chemical binding]; other site 454166010309 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166010310 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 454166010311 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166010312 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454166010313 substrate binding site [chemical binding]; other site 454166010314 dimer interface [polypeptide binding]; other site 454166010315 ATP binding site [chemical binding]; other site 454166010316 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 454166010317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 454166010318 Protein of unknown function, DUF606; Region: DUF606; pfam04657 454166010319 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 454166010320 active site 454166010321 substrate binding pocket [chemical binding]; other site 454166010322 homodimer interaction site [polypeptide binding]; other site 454166010323 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 454166010324 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 454166010325 hypothetical protein; Provisional; Region: PRK10350 454166010326 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 454166010327 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 454166010328 putative active site [active] 454166010329 catalytic site [active] 454166010330 putative metal binding site [ion binding]; other site 454166010331 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 454166010332 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 454166010333 Walker A/P-loop; other site 454166010334 ATP binding site [chemical binding]; other site 454166010335 Q-loop/lid; other site 454166010336 ABC transporter signature motif; other site 454166010337 Walker B; other site 454166010338 D-loop; other site 454166010339 H-loop/switch region; other site 454166010340 TOBE domain; Region: TOBE_2; pfam08402 454166010341 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 454166010342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166010343 dimer interface [polypeptide binding]; other site 454166010344 conserved gate region; other site 454166010345 ABC-ATPase subunit interface; other site 454166010346 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 454166010347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166010348 dimer interface [polypeptide binding]; other site 454166010349 conserved gate region; other site 454166010350 putative PBP binding loops; other site 454166010351 ABC-ATPase subunit interface; other site 454166010352 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 454166010353 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 454166010354 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 454166010355 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 454166010356 Walker A/P-loop; other site 454166010357 ATP binding site [chemical binding]; other site 454166010358 Q-loop/lid; other site 454166010359 ABC transporter signature motif; other site 454166010360 Walker B; other site 454166010361 D-loop; other site 454166010362 H-loop/switch region; other site 454166010363 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 454166010364 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 454166010365 Walker A/P-loop; other site 454166010366 ATP binding site [chemical binding]; other site 454166010367 Q-loop/lid; other site 454166010368 ABC transporter signature motif; other site 454166010369 Walker B; other site 454166010370 D-loop; other site 454166010371 H-loop/switch region; other site 454166010372 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 454166010373 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 454166010374 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 454166010375 TM-ABC transporter signature motif; other site 454166010376 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454166010377 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 454166010378 TM-ABC transporter signature motif; other site 454166010379 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 454166010380 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 454166010381 dimerization interface [polypeptide binding]; other site 454166010382 ligand binding site [chemical binding]; other site 454166010383 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 454166010384 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 454166010385 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 454166010386 dimerization interface [polypeptide binding]; other site 454166010387 ligand binding site [chemical binding]; other site 454166010388 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 454166010389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 454166010390 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 454166010391 DNA binding residues [nucleotide binding] 454166010392 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 454166010393 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 454166010394 cell division protein FtsE; Provisional; Region: PRK10908 454166010395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166010396 Walker A/P-loop; other site 454166010397 ATP binding site [chemical binding]; other site 454166010398 Q-loop/lid; other site 454166010399 ABC transporter signature motif; other site 454166010400 Walker B; other site 454166010401 D-loop; other site 454166010402 H-loop/switch region; other site 454166010403 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 454166010404 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 454166010405 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 454166010406 P loop; other site 454166010407 GTP binding site [chemical binding]; other site 454166010408 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 454166010409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166010410 S-adenosylmethionine binding site [chemical binding]; other site 454166010411 hypothetical protein; Provisional; Region: PRK10910 454166010412 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 454166010413 Predicted membrane protein [Function unknown]; Region: COG3714 454166010414 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 454166010415 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 454166010416 metal-binding site [ion binding] 454166010417 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454166010418 Soluble P-type ATPase [General function prediction only]; Region: COG4087 454166010419 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 454166010420 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 454166010421 dimer interface [polypeptide binding]; other site 454166010422 ligand binding site [chemical binding]; other site 454166010423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166010424 dimerization interface [polypeptide binding]; other site 454166010425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 454166010426 dimer interface [polypeptide binding]; other site 454166010427 putative CheW interface [polypeptide binding]; other site 454166010428 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 454166010429 CPxP motif; other site 454166010430 hypothetical protein; Provisional; Region: PRK11212 454166010431 hypothetical protein; Provisional; Region: PRK11615 454166010432 major facilitator superfamily transporter; Provisional; Region: PRK05122 454166010433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166010434 putative substrate translocation pore; other site 454166010435 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 454166010436 Domain of unknown function DUF20; Region: UPF0118; pfam01594 454166010437 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 454166010438 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 454166010439 nickel responsive regulator; Provisional; Region: PRK02967 454166010440 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 454166010441 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454166010442 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 454166010443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454166010444 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 454166010445 Walker A/P-loop; other site 454166010446 ATP binding site [chemical binding]; other site 454166010447 Q-loop/lid; other site 454166010448 ABC transporter signature motif; other site 454166010449 Walker B; other site 454166010450 D-loop; other site 454166010451 H-loop/switch region; other site 454166010452 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 454166010453 Walker A/P-loop; other site 454166010454 ATP binding site [chemical binding]; other site 454166010455 Q-loop/lid; other site 454166010456 ABC transporter signature motif; other site 454166010457 Walker B; other site 454166010458 D-loop; other site 454166010459 H-loop/switch region; other site 454166010460 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 454166010461 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 454166010462 HlyD family secretion protein; Region: HlyD; pfam00529 454166010463 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166010464 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166010465 Predicted flavoproteins [General function prediction only]; Region: COG2081 454166010466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454166010467 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 454166010468 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 454166010469 universal stress protein UspB; Provisional; Region: PRK04960 454166010470 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 454166010471 Ligand Binding Site [chemical binding]; other site 454166010472 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 454166010473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166010474 putative substrate translocation pore; other site 454166010475 POT family; Region: PTR2; pfam00854 454166010476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166010477 S-adenosylmethionine binding site [chemical binding]; other site 454166010478 oligopeptidase A; Provisional; Region: PRK10911 454166010479 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 454166010480 active site 454166010481 Zn binding site [ion binding]; other site 454166010482 hypothetical protein; Provisional; Region: PRK10215 454166010483 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 454166010484 glutathione reductase; Validated; Region: PRK06116 454166010485 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 454166010486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166010487 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454166010488 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 454166010489 active site 454166010490 homodimer interface [polypeptide binding]; other site 454166010491 homotetramer interface [polypeptide binding]; other site 454166010492 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 454166010493 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 454166010494 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 454166010495 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166010496 substrate binding site [chemical binding]; other site 454166010497 ATP binding site [chemical binding]; other site 454166010498 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 454166010499 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 454166010500 putative active site [active] 454166010501 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 454166010502 dimer interface [polypeptide binding]; other site 454166010503 active site 454166010504 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454166010505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166010506 DNA-binding site [nucleotide binding]; DNA binding site 454166010507 UTRA domain; Region: UTRA; pfam07702 454166010508 trehalase; Provisional; Region: treF; PRK13270 454166010509 Trehalase; Region: Trehalase; pfam01204 454166010510 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 454166010511 catalytic residue [active] 454166010512 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454166010513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 454166010514 active site 454166010515 phosphorylation site [posttranslational modification] 454166010516 dimerization interface [polypeptide binding]; other site 454166010517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166010518 DNA binding residues [nucleotide binding] 454166010519 dimerization interface [polypeptide binding]; other site 454166010520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166010521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166010522 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 454166010523 putative effector binding pocket; other site 454166010524 putative dimerization interface [polypeptide binding]; other site 454166010525 inner membrane protein YhjD; Region: TIGR00766 454166010526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166010527 metabolite-proton symporter; Region: 2A0106; TIGR00883 454166010528 putative substrate translocation pore; other site 454166010529 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 454166010530 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 454166010531 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166010532 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 454166010533 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 454166010534 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 454166010535 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454166010536 putative diguanylate cyclase; Provisional; Region: PRK13561 454166010537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166010538 metal binding site [ion binding]; metal-binding site 454166010539 active site 454166010540 I-site; other site 454166010541 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166010542 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 454166010543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 454166010544 TPR motif; other site 454166010545 binding surface 454166010546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166010547 TPR motif; other site 454166010548 binding surface 454166010549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 454166010550 binding surface 454166010551 TPR motif; other site 454166010552 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 454166010553 endo-1,4-D-glucanase; Provisional; Region: PRK11097 454166010554 cellulose synthase regulator protein; Provisional; Region: PRK11114 454166010555 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 454166010556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454166010557 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 454166010558 DXD motif; other site 454166010559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454166010560 PilZ domain; Region: PilZ; pfam07238 454166010561 cell division protein; Provisional; Region: PRK10037 454166010562 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 454166010563 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 454166010564 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 454166010565 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 454166010566 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 454166010567 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 454166010568 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 454166010569 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 454166010570 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 454166010571 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 454166010572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166010573 Walker A/P-loop; other site 454166010574 ATP binding site [chemical binding]; other site 454166010575 Q-loop/lid; other site 454166010576 ABC transporter signature motif; other site 454166010577 Walker B; other site 454166010578 D-loop; other site 454166010579 H-loop/switch region; other site 454166010580 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 454166010581 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 454166010582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 454166010583 Walker A/P-loop; other site 454166010584 ATP binding site [chemical binding]; other site 454166010585 Q-loop/lid; other site 454166010586 ABC transporter signature motif; other site 454166010587 Walker B; other site 454166010588 D-loop; other site 454166010589 H-loop/switch region; other site 454166010590 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 454166010591 dipeptide transporter; Provisional; Region: PRK10913 454166010592 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 454166010593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166010594 dimer interface [polypeptide binding]; other site 454166010595 conserved gate region; other site 454166010596 putative PBP binding loops; other site 454166010597 ABC-ATPase subunit interface; other site 454166010598 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 454166010599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166010600 dimer interface [polypeptide binding]; other site 454166010601 conserved gate region; other site 454166010602 putative PBP binding loops; other site 454166010603 ABC-ATPase subunit interface; other site 454166010604 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 454166010605 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 454166010606 peptide binding site [polypeptide binding]; other site 454166010607 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 454166010608 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 454166010609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454166010610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166010611 DNA binding site [nucleotide binding] 454166010612 domain linker motif; other site 454166010613 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 454166010614 putative dimerization interface [polypeptide binding]; other site 454166010615 putative ligand binding site [chemical binding]; other site 454166010616 phosphoethanolamine transferase; Provisional; Region: PRK11560 454166010617 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 454166010618 Sulfatase; Region: Sulfatase; pfam00884 454166010619 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 454166010620 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 454166010621 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 454166010622 PapC N-terminal domain; Region: PapC_N; pfam13954 454166010623 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166010624 PapC C-terminal domain; Region: PapC_C; pfam13953 454166010625 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 454166010626 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166010627 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166010628 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 454166010629 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 454166010630 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 454166010631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166010632 Coenzyme A binding pocket [chemical binding]; other site 454166010633 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 454166010634 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 454166010635 molybdopterin cofactor binding site [chemical binding]; other site 454166010636 substrate binding site [chemical binding]; other site 454166010637 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 454166010638 molybdopterin cofactor binding site; other site 454166010639 putative outer membrane lipoprotein; Provisional; Region: PRK10510 454166010640 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 454166010641 ligand binding site [chemical binding]; other site 454166010642 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 454166010643 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 454166010644 dimerization interface [polypeptide binding]; other site 454166010645 ligand binding site [chemical binding]; other site 454166010646 NADP binding site [chemical binding]; other site 454166010647 catalytic site [active] 454166010648 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 454166010649 Predicted transcriptional regulator [Transcription]; Region: COG2944 454166010650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166010651 salt bridge; other site 454166010652 non-specific DNA binding site [nucleotide binding]; other site 454166010653 sequence-specific DNA binding site [nucleotide binding]; other site 454166010654 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 454166010655 DNA-binding site [nucleotide binding]; DNA binding site 454166010656 RNA-binding motif; other site 454166010657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 454166010658 Integrase core domain; Region: rve; pfam00665 454166010659 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 454166010660 DALR anticodon binding domain; Region: DALR_1; pfam05746 454166010661 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 454166010662 dimer interface [polypeptide binding]; other site 454166010663 motif 1; other site 454166010664 active site 454166010665 motif 2; other site 454166010666 motif 3; other site 454166010667 YsaB-like lipoprotein; Region: YsaB; pfam13983 454166010668 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 454166010669 Acyltransferase family; Region: Acyl_transf_3; pfam01757 454166010670 Predicted membrane protein [Function unknown]; Region: COG4682 454166010671 yiaA/B two helix domain; Region: YiaAB; cl01759 454166010672 yiaA/B two helix domain; Region: YiaAB; cl01759 454166010673 xylulokinase; Provisional; Region: PRK15027 454166010674 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 454166010675 N- and C-terminal domain interface [polypeptide binding]; other site 454166010676 active site 454166010677 MgATP binding site [chemical binding]; other site 454166010678 catalytic site [active] 454166010679 metal binding site [ion binding]; metal-binding site 454166010680 xylulose binding site [chemical binding]; other site 454166010681 homodimer interface [polypeptide binding]; other site 454166010682 xylose isomerase; Provisional; Region: PRK05474 454166010683 xylose isomerase; Region: xylose_isom_A; TIGR02630 454166010684 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 454166010685 putative dimerization interface [polypeptide binding]; other site 454166010686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454166010687 putative ligand binding site [chemical binding]; other site 454166010688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166010689 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166010690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166010691 hypothetical protein; Provisional; Region: PRK10356 454166010692 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 454166010693 alpha-amylase; Reviewed; Region: malS; PRK09505 454166010694 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 454166010695 active site 454166010696 catalytic site [active] 454166010697 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 454166010698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166010699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166010700 homodimer interface [polypeptide binding]; other site 454166010701 catalytic residue [active] 454166010702 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 454166010703 Transcriptional regulator [Transcription]; Region: IclR; COG1414 454166010704 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454166010705 Bacterial transcriptional regulator; Region: IclR; pfam01614 454166010706 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 454166010707 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454166010708 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 454166010709 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 454166010710 DctM-like transporters; Region: DctM; pfam06808 454166010711 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 454166010712 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 454166010713 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 454166010714 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 454166010715 putative N- and C-terminal domain interface [polypeptide binding]; other site 454166010716 putative active site [active] 454166010717 MgATP binding site [chemical binding]; other site 454166010718 catalytic site [active] 454166010719 metal binding site [ion binding]; metal-binding site 454166010720 putative xylulose binding site [chemical binding]; other site 454166010721 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 454166010722 active site 454166010723 dimer interface [polypeptide binding]; other site 454166010724 magnesium binding site [ion binding]; other site 454166010725 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 454166010726 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 454166010727 AP (apurinic/apyrimidinic) site pocket; other site 454166010728 DNA interaction; other site 454166010729 Metal-binding active site; metal-binding site 454166010730 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454166010731 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454166010732 intersubunit interface [polypeptide binding]; other site 454166010733 active site 454166010734 Zn2+ binding site [ion binding]; other site 454166010735 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454166010736 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 454166010737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166010738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 454166010739 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 454166010740 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 454166010741 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 454166010742 NAD(P) binding site [chemical binding]; other site 454166010743 catalytic residues [active] 454166010744 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 454166010745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 454166010746 nucleotide binding site [chemical binding]; other site 454166010747 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 454166010748 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 454166010749 G1 box; other site 454166010750 putative GEF interaction site [polypeptide binding]; other site 454166010751 GTP/Mg2+ binding site [chemical binding]; other site 454166010752 Switch I region; other site 454166010753 G2 box; other site 454166010754 G3 box; other site 454166010755 Switch II region; other site 454166010756 G4 box; other site 454166010757 G5 box; other site 454166010758 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 454166010759 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 454166010760 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 454166010761 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 454166010762 selenocysteine synthase; Provisional; Region: PRK04311 454166010763 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 454166010764 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 454166010765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166010766 catalytic residue [active] 454166010767 putative glutathione S-transferase; Provisional; Region: PRK10357 454166010768 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 454166010769 putative C-terminal domain interface [polypeptide binding]; other site 454166010770 putative GSH binding site (G-site) [chemical binding]; other site 454166010771 putative dimer interface [polypeptide binding]; other site 454166010772 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 454166010773 dimer interface [polypeptide binding]; other site 454166010774 N-terminal domain interface [polypeptide binding]; other site 454166010775 putative substrate binding pocket (H-site) [chemical binding]; other site 454166010776 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 454166010777 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166010778 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166010779 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 454166010780 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 454166010781 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 454166010782 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 454166010783 active site 454166010784 P-loop; other site 454166010785 phosphorylation site [posttranslational modification] 454166010786 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166010787 active site 454166010788 phosphorylation site [posttranslational modification] 454166010789 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 454166010790 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 454166010791 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 454166010792 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 454166010793 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 454166010794 hypothetical protein; Provisional; Region: PRK11020 454166010795 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 454166010796 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 454166010797 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 454166010798 trimer interface [polypeptide binding]; other site 454166010799 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 454166010800 Haemagglutinin; Region: HIM; pfam05662 454166010801 Haemagglutinin; Region: HIM; pfam05662 454166010802 YadA-like C-terminal region; Region: YadA; pfam03895 454166010803 L-lactate permease; Provisional; Region: PRK10420 454166010804 glycolate transporter; Provisional; Region: PRK09695 454166010805 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 454166010806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166010807 DNA-binding site [nucleotide binding]; DNA binding site 454166010808 FCD domain; Region: FCD; pfam07729 454166010809 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 454166010810 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 454166010811 active site 454166010812 substrate binding site [chemical binding]; other site 454166010813 FMN binding site [chemical binding]; other site 454166010814 putative catalytic residues [active] 454166010815 putative rRNA methylase; Provisional; Region: PRK10358 454166010816 Transcriptional regulators [Transcription]; Region: PurR; COG1609 454166010817 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166010818 DNA binding site [nucleotide binding] 454166010819 domain linker motif; other site 454166010820 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454166010821 putative dimerization interface [polypeptide binding]; other site 454166010822 putative ligand binding site [chemical binding]; other site 454166010823 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 454166010824 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 454166010825 active site pocket [active] 454166010826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166010827 D-galactonate transporter; Region: 2A0114; TIGR00893 454166010828 putative substrate translocation pore; other site 454166010829 serine acetyltransferase; Provisional; Region: cysE; PRK11132 454166010830 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 454166010831 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 454166010832 trimer interface [polypeptide binding]; other site 454166010833 active site 454166010834 substrate binding site [chemical binding]; other site 454166010835 CoA binding site [chemical binding]; other site 454166010836 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 454166010837 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 454166010838 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 454166010839 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 454166010840 SecA binding site; other site 454166010841 Preprotein binding site; other site 454166010842 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 454166010843 GSH binding site [chemical binding]; other site 454166010844 catalytic residues [active] 454166010845 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 454166010846 active site residue [active] 454166010847 phosphoglyceromutase; Provisional; Region: PRK05434 454166010848 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 454166010849 AmiB activator; Provisional; Region: PRK11637 454166010850 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 454166010851 Peptidase family M23; Region: Peptidase_M23; pfam01551 454166010852 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 454166010853 NodB motif; other site 454166010854 putative active site [active] 454166010855 putative catalytic site [active] 454166010856 Zn binding site [ion binding]; other site 454166010857 putative glycosyl transferase; Provisional; Region: PRK10073 454166010858 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 454166010859 active site 454166010860 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 454166010861 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 454166010862 NAD(P) binding site [chemical binding]; other site 454166010863 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 454166010864 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 454166010865 substrate-cofactor binding pocket; other site 454166010866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166010867 catalytic residue [active] 454166010868 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 454166010869 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 454166010870 NADP binding site [chemical binding]; other site 454166010871 homopentamer interface [polypeptide binding]; other site 454166010872 substrate binding site [chemical binding]; other site 454166010873 active site 454166010874 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 454166010875 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 454166010876 putative active site [active] 454166010877 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 454166010878 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 454166010879 putative active site [active] 454166010880 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 454166010881 O-antigen ligase RfaL; Provisional; Region: PRK15487 454166010882 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 454166010883 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 454166010884 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 454166010885 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 454166010886 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 454166010887 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 454166010888 Ligand binding site; other site 454166010889 metal-binding site 454166010890 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 454166010891 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 454166010892 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 454166010893 Ligand binding site; other site 454166010894 metal-binding site 454166010895 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 454166010896 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 454166010897 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 454166010898 putative ADP-binding pocket [chemical binding]; other site 454166010899 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 454166010900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 454166010901 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 454166010902 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 454166010903 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 454166010904 putative active site [active] 454166010905 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 454166010906 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 454166010907 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 454166010908 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 454166010909 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 454166010910 active site 454166010911 (T/H)XGH motif; other site 454166010912 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 454166010913 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 454166010914 DNA binding site [nucleotide binding] 454166010915 catalytic residue [active] 454166010916 H2TH interface [polypeptide binding]; other site 454166010917 putative catalytic residues [active] 454166010918 turnover-facilitating residue; other site 454166010919 intercalation triad [nucleotide binding]; other site 454166010920 8OG recognition residue [nucleotide binding]; other site 454166010921 putative reading head residues; other site 454166010922 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 454166010923 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 454166010924 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 454166010925 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 454166010926 hypothetical protein; Reviewed; Region: PRK00024 454166010927 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 454166010928 MPN+ (JAMM) motif; other site 454166010929 Zinc-binding site [ion binding]; other site 454166010930 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 454166010931 trimer interface [polypeptide binding]; other site 454166010932 active site 454166010933 division inhibitor protein; Provisional; Region: slmA; PRK09480 454166010934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166010935 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 454166010936 active site 454166010937 ribonuclease PH; Reviewed; Region: rph; PRK00173 454166010938 Ribonuclease PH; Region: RNase_PH_bact; cd11362 454166010939 hexamer interface [polypeptide binding]; other site 454166010940 active site 454166010941 hypothetical protein; Provisional; Region: PRK11820 454166010942 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 454166010943 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 454166010944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166010945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166010946 dimerization interface [polypeptide binding]; other site 454166010947 LysR substrate binding domain; Region: LysR_substrate; pfam03466 454166010948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 454166010949 Predicted membrane protein [Function unknown]; Region: COG2860 454166010950 UPF0126 domain; Region: UPF0126; pfam03458 454166010951 UPF0126 domain; Region: UPF0126; pfam03458 454166010952 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 454166010953 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 454166010954 nucleotide binding pocket [chemical binding]; other site 454166010955 K-X-D-G motif; other site 454166010956 catalytic site [active] 454166010957 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 454166010958 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 454166010959 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 454166010960 catalytic site [active] 454166010961 G-X2-G-X-G-K; other site 454166010962 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 454166010963 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 454166010964 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 454166010965 Zn2+ binding site [ion binding]; other site 454166010966 Mg2+ binding site [ion binding]; other site 454166010967 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 454166010968 synthetase active site [active] 454166010969 NTP binding site [chemical binding]; other site 454166010970 metal binding site [ion binding]; metal-binding site 454166010971 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 454166010972 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 454166010973 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 454166010974 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 454166010975 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 454166010976 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 454166010977 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 454166010978 generic binding surface II; other site 454166010979 ssDNA binding site; other site 454166010980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166010981 ATP binding site [chemical binding]; other site 454166010982 putative Mg++ binding site [ion binding]; other site 454166010983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166010984 nucleotide binding region [chemical binding]; other site 454166010985 ATP-binding site [chemical binding]; other site 454166010986 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 454166010987 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 454166010988 AsmA family; Region: AsmA; pfam05170 454166010989 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 454166010990 putative alpha-glucosidase; Provisional; Region: PRK10658 454166010991 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 454166010992 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 454166010993 active site 454166010994 homotrimer interface [polypeptide binding]; other site 454166010995 catalytic site [active] 454166010996 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 454166010997 putative transporter; Provisional; Region: PRK11462 454166010998 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454166010999 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 454166011000 putative fimbrial protein StaF; Provisional; Region: PRK15262 454166011001 putative fimbrial protein StaE; Provisional; Region: PRK15263 454166011002 Fimbrial protein; Region: Fimbrial; cl01416 454166011003 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 454166011004 PapC N-terminal domain; Region: PapC_N; pfam13954 454166011005 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166011006 PapC C-terminal domain; Region: PapC_C; pfam13953 454166011007 putative chaperone protein EcpD; Provisional; Region: PRK09926 454166011008 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166011009 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166011010 Fimbrial protein; Region: Fimbrial; cl01416 454166011011 Homeodomain-like domain; Region: HTH_23; pfam13384 454166011012 autotransport protein MisL; Provisional; Region: PRK15313 454166011013 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 454166011014 Autotransporter beta-domain; Region: Autotransporter; pfam03797 454166011015 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 454166011016 DNA binding site [nucleotide binding] 454166011017 Isochorismatase family; Region: Isochorismatase; pfam00857 454166011018 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 454166011019 catalytic triad [active] 454166011020 dimer interface [polypeptide binding]; other site 454166011021 conserved cis-peptide bond; other site 454166011022 magnesium-transporting ATPase; Provisional; Region: PRK15122 454166011023 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 454166011024 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454166011025 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 454166011026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011027 motif II; other site 454166011028 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 454166011029 magnesium transport protein MgtC; Provisional; Region: PRK15385 454166011030 MgtC family; Region: MgtC; pfam02308 454166011031 EamA-like transporter family; Region: EamA; pfam00892 454166011032 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 454166011033 EamA-like transporter family; Region: EamA; pfam00892 454166011034 hypothetical protein; Provisional; Region: PRK09956 454166011035 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454166011036 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 454166011037 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 454166011038 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 454166011039 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 454166011040 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 454166011041 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 454166011042 active site 454166011043 phosphorylation site [posttranslational modification] 454166011044 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 454166011045 active pocket/dimerization site; other site 454166011046 active site 454166011047 phosphorylation site [posttranslational modification] 454166011048 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 454166011049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166011050 Walker A motif; other site 454166011051 ATP binding site [chemical binding]; other site 454166011052 Walker B motif; other site 454166011053 arginine finger; other site 454166011054 Transcriptional antiterminator [Transcription]; Region: COG3933 454166011055 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 454166011056 active site 454166011057 active pocket/dimerization site; other site 454166011058 phosphorylation site [posttranslational modification] 454166011059 PRD domain; Region: PRD; pfam00874 454166011060 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 454166011061 beta-galactosidase; Region: BGL; TIGR03356 454166011062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 454166011063 Predicted transcriptional regulator [Transcription]; Region: COG2944 454166011064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166011065 non-specific DNA binding site [nucleotide binding]; other site 454166011066 salt bridge; other site 454166011067 sequence-specific DNA binding site [nucleotide binding]; other site 454166011068 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 454166011069 dimerization domain swap beta strand [polypeptide binding]; other site 454166011070 regulatory protein interface [polypeptide binding]; other site 454166011071 active site 454166011072 regulatory phosphorylation site [posttranslational modification]; other site 454166011073 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 454166011074 intersubunit interface [polypeptide binding]; other site 454166011075 active site 454166011076 zinc binding site [ion binding]; other site 454166011077 Na+ binding site [ion binding]; other site 454166011078 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 454166011079 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 454166011080 putative N- and C-terminal domain interface [polypeptide binding]; other site 454166011081 putative active site [active] 454166011082 putative MgATP binding site [chemical binding]; other site 454166011083 catalytic site [active] 454166011084 metal binding site [ion binding]; metal-binding site 454166011085 putative carbohydrate binding site [chemical binding]; other site 454166011086 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 454166011087 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 454166011088 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 454166011089 active site 454166011090 P-loop; other site 454166011091 phosphorylation site [posttranslational modification] 454166011092 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166011093 active site 454166011094 phosphorylation site [posttranslational modification] 454166011095 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454166011096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166011097 DNA-binding site [nucleotide binding]; DNA binding site 454166011098 UTRA domain; Region: UTRA; pfam07702 454166011099 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 454166011100 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 454166011101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011102 putative substrate translocation pore; other site 454166011103 regulatory protein UhpC; Provisional; Region: PRK11663 454166011104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011105 putative substrate translocation pore; other site 454166011106 sensory histidine kinase UhpB; Provisional; Region: PRK11644 454166011107 MASE1; Region: MASE1; pfam05231 454166011108 Histidine kinase; Region: HisKA_3; pfam07730 454166011109 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 454166011110 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 454166011111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166011112 active site 454166011113 phosphorylation site [posttranslational modification] 454166011114 intermolecular recognition site; other site 454166011115 dimerization interface [polypeptide binding]; other site 454166011116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166011117 DNA binding residues [nucleotide binding] 454166011118 dimerization interface [polypeptide binding]; other site 454166011119 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 454166011120 active site 454166011121 catalytic residues [active] 454166011122 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 454166011123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011124 putative substrate translocation pore; other site 454166011125 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166011126 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454166011127 substrate binding site [chemical binding]; other site 454166011128 dimer interface [polypeptide binding]; other site 454166011129 ATP binding site [chemical binding]; other site 454166011130 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 454166011131 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 454166011132 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166011133 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 454166011134 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 454166011135 putative valine binding site [chemical binding]; other site 454166011136 dimer interface [polypeptide binding]; other site 454166011137 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 454166011138 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454166011139 PYR/PP interface [polypeptide binding]; other site 454166011140 dimer interface [polypeptide binding]; other site 454166011141 TPP binding site [chemical binding]; other site 454166011142 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454166011143 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 454166011144 TPP-binding site [chemical binding]; other site 454166011145 dimer interface [polypeptide binding]; other site 454166011146 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 454166011147 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 454166011148 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 454166011149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011150 putative substrate translocation pore; other site 454166011151 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 454166011152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166011153 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 454166011154 dimerization interface [polypeptide binding]; other site 454166011155 substrate binding pocket [chemical binding]; other site 454166011156 permease DsdX; Provisional; Region: PRK09921 454166011157 gluconate transporter; Region: gntP; TIGR00791 454166011158 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 454166011159 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 454166011160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 454166011161 catalytic residue [active] 454166011162 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 454166011163 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 454166011164 Domain of unknown function (DUF202); Region: DUF202; pfam02656 454166011165 Predicted membrane protein [Function unknown]; Region: COG2149 454166011166 putative transporter; Validated; Region: PRK03818 454166011167 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 454166011168 TrkA-C domain; Region: TrkA_C; pfam02080 454166011169 TrkA-C domain; Region: TrkA_C; pfam02080 454166011170 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 454166011171 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 454166011172 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 454166011173 putative dimer interface [polypeptide binding]; other site 454166011174 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 454166011175 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 454166011176 putative dimer interface [polypeptide binding]; other site 454166011177 hypothetical protein; Provisional; Region: PRK11616 454166011178 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 454166011179 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 454166011180 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 454166011181 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 454166011182 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 454166011183 catalytic residues [active] 454166011184 central insert; other site 454166011185 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 454166011186 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 454166011187 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 454166011188 heme exporter protein CcmC; Region: ccmC; TIGR01191 454166011189 heme exporter protein CcmB; Region: ccmB; TIGR01190 454166011190 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 454166011191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166011192 Walker A/P-loop; other site 454166011193 ATP binding site [chemical binding]; other site 454166011194 Q-loop/lid; other site 454166011195 ABC transporter signature motif; other site 454166011196 Walker B; other site 454166011197 D-loop; other site 454166011198 H-loop/switch region; other site 454166011199 Haem-binding domain; Region: Haem_bd; pfam14376 454166011200 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 454166011201 chaperone protein TorD; Validated; Region: torD; PRK04976 454166011202 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 454166011203 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 454166011204 molybdopterin cofactor binding site [chemical binding]; other site 454166011205 substrate binding site [chemical binding]; other site 454166011206 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 454166011207 molybdopterin cofactor binding site; other site 454166011208 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 454166011209 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 454166011210 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 454166011211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166011212 active site 454166011213 phosphorylation site [posttranslational modification] 454166011214 intermolecular recognition site; other site 454166011215 dimerization interface [polypeptide binding]; other site 454166011216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166011217 DNA binding site [nucleotide binding] 454166011218 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 454166011219 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 454166011220 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 454166011221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166011222 dimer interface [polypeptide binding]; other site 454166011223 phosphorylation site [posttranslational modification] 454166011224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166011225 ATP binding site [chemical binding]; other site 454166011226 Mg2+ binding site [ion binding]; other site 454166011227 G-X-G motif; other site 454166011228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166011229 active site 454166011230 phosphorylation site [posttranslational modification] 454166011231 intermolecular recognition site; other site 454166011232 dimerization interface [polypeptide binding]; other site 454166011233 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 454166011234 putative binding surface; other site 454166011235 active site 454166011236 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 454166011237 Surface antigen; Region: Bac_surface_Ag; pfam01103 454166011238 sugar phosphate phosphatase; Provisional; Region: PRK10513 454166011239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011240 active site 454166011241 motif I; other site 454166011242 motif II; other site 454166011243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011244 hypothetical protein; Provisional; Region: PRK10215 454166011245 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 454166011246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166011247 Mg2+ binding site [ion binding]; other site 454166011248 G-X-G motif; other site 454166011249 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 454166011250 anchoring element; other site 454166011251 dimer interface [polypeptide binding]; other site 454166011252 ATP binding site [chemical binding]; other site 454166011253 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 454166011254 active site 454166011255 putative metal-binding site [ion binding]; other site 454166011256 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 454166011257 recF protein; Region: recf; TIGR00611 454166011258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166011259 Walker A/P-loop; other site 454166011260 ATP binding site [chemical binding]; other site 454166011261 Q-loop/lid; other site 454166011262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166011263 ABC transporter signature motif; other site 454166011264 Walker B; other site 454166011265 D-loop; other site 454166011266 H-loop/switch region; other site 454166011267 DNA polymerase III subunit beta; Validated; Region: PRK05643 454166011268 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 454166011269 putative DNA binding surface [nucleotide binding]; other site 454166011270 dimer interface [polypeptide binding]; other site 454166011271 beta-clamp/clamp loader binding surface; other site 454166011272 beta-clamp/translesion DNA polymerase binding surface; other site 454166011273 DnaA N-terminal domain; Region: DnaA_N; pfam11638 454166011274 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 454166011275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166011276 Walker A motif; other site 454166011277 ATP binding site [chemical binding]; other site 454166011278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 454166011279 Walker B motif; other site 454166011280 arginine finger; other site 454166011281 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 454166011282 DnaA box-binding interface [nucleotide binding]; other site 454166011283 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 454166011284 ribonuclease P; Reviewed; Region: rnpA; PRK01732 454166011285 membrane protein insertase; Provisional; Region: PRK01318 454166011286 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 454166011287 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 454166011288 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 454166011289 trmE is a tRNA modification GTPase; Region: trmE; cd04164 454166011290 G1 box; other site 454166011291 GTP/Mg2+ binding site [chemical binding]; other site 454166011292 Switch I region; other site 454166011293 G2 box; other site 454166011294 Switch II region; other site 454166011295 G3 box; other site 454166011296 G4 box; other site 454166011297 G5 box; other site 454166011298 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 454166011299 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 454166011300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011301 putative substrate translocation pore; other site 454166011302 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 454166011303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166011304 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 454166011305 substrate binding pocket [chemical binding]; other site 454166011306 dimerization interface [polypeptide binding]; other site 454166011307 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 454166011308 Predicted flavoprotein [General function prediction only]; Region: COG0431 454166011309 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 454166011310 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 454166011311 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 454166011312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011313 active site 454166011314 motif I; other site 454166011315 motif II; other site 454166011316 transcriptional regulator PhoU; Provisional; Region: PRK11115 454166011317 PhoU domain; Region: PhoU; pfam01895 454166011318 PhoU domain; Region: PhoU; pfam01895 454166011319 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 454166011320 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 454166011321 Walker A/P-loop; other site 454166011322 ATP binding site [chemical binding]; other site 454166011323 Q-loop/lid; other site 454166011324 ABC transporter signature motif; other site 454166011325 Walker B; other site 454166011326 D-loop; other site 454166011327 H-loop/switch region; other site 454166011328 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 454166011329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166011330 dimer interface [polypeptide binding]; other site 454166011331 conserved gate region; other site 454166011332 putative PBP binding loops; other site 454166011333 ABC-ATPase subunit interface; other site 454166011334 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 454166011335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166011336 dimer interface [polypeptide binding]; other site 454166011337 conserved gate region; other site 454166011338 putative PBP binding loops; other site 454166011339 ABC-ATPase subunit interface; other site 454166011340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166011341 substrate binding pocket [chemical binding]; other site 454166011342 membrane-bound complex binding site; other site 454166011343 hinge residues; other site 454166011344 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 454166011345 active site 454166011346 P-loop; other site 454166011347 phosphorylation site [posttranslational modification] 454166011348 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 454166011349 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 454166011350 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 454166011351 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 454166011352 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 454166011353 shikimate binding site; other site 454166011354 NAD(P) binding site [chemical binding]; other site 454166011355 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 454166011356 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 454166011357 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 454166011358 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 454166011359 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 454166011360 glutaminase active site [active] 454166011361 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 454166011362 dimer interface [polypeptide binding]; other site 454166011363 active site 454166011364 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 454166011365 dimer interface [polypeptide binding]; other site 454166011366 active site 454166011367 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 454166011368 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 454166011369 Substrate binding site; other site 454166011370 Mg++ binding site; other site 454166011371 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 454166011372 active site 454166011373 substrate binding site [chemical binding]; other site 454166011374 CoA binding site [chemical binding]; other site 454166011375 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 454166011376 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 454166011377 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 454166011378 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 454166011379 gamma subunit interface [polypeptide binding]; other site 454166011380 epsilon subunit interface [polypeptide binding]; other site 454166011381 LBP interface [polypeptide binding]; other site 454166011382 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 454166011383 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 454166011384 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 454166011385 alpha subunit interaction interface [polypeptide binding]; other site 454166011386 Walker A motif; other site 454166011387 ATP binding site [chemical binding]; other site 454166011388 Walker B motif; other site 454166011389 inhibitor binding site; inhibition site 454166011390 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 454166011391 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 454166011392 core domain interface [polypeptide binding]; other site 454166011393 delta subunit interface [polypeptide binding]; other site 454166011394 epsilon subunit interface [polypeptide binding]; other site 454166011395 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 454166011396 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 454166011397 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 454166011398 beta subunit interaction interface [polypeptide binding]; other site 454166011399 Walker A motif; other site 454166011400 ATP binding site [chemical binding]; other site 454166011401 Walker B motif; other site 454166011402 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 454166011403 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 454166011404 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 454166011405 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 454166011406 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 454166011407 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 454166011408 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 454166011409 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 454166011410 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 454166011411 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 454166011412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166011413 S-adenosylmethionine binding site [chemical binding]; other site 454166011414 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 454166011415 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 454166011416 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 454166011417 FMN-binding protein MioC; Provisional; Region: PRK09004 454166011418 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 454166011419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166011420 putative DNA binding site [nucleotide binding]; other site 454166011421 putative Zn2+ binding site [ion binding]; other site 454166011422 AsnC family; Region: AsnC_trans_reg; pfam01037 454166011423 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 454166011424 dimer interface [polypeptide binding]; other site 454166011425 active site 454166011426 hypothetical protein; Provisional; Region: yieM; PRK10997 454166011427 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 454166011428 metal ion-dependent adhesion site (MIDAS); other site 454166011429 regulatory ATPase RavA; Provisional; Region: PRK13531 454166011430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166011431 Walker A motif; other site 454166011432 ATP binding site [chemical binding]; other site 454166011433 Walker B motif; other site 454166011434 arginine finger; other site 454166011435 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 454166011436 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 454166011437 potassium uptake protein; Region: kup; TIGR00794 454166011438 D-ribose pyranase; Provisional; Region: PRK11797 454166011439 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 454166011440 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 454166011441 Walker A/P-loop; other site 454166011442 ATP binding site [chemical binding]; other site 454166011443 Q-loop/lid; other site 454166011444 ABC transporter signature motif; other site 454166011445 Walker B; other site 454166011446 D-loop; other site 454166011447 H-loop/switch region; other site 454166011448 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 454166011449 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454166011450 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454166011451 TM-ABC transporter signature motif; other site 454166011452 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 454166011453 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 454166011454 ligand binding site [chemical binding]; other site 454166011455 dimerization interface [polypeptide binding]; other site 454166011456 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166011457 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 454166011458 substrate binding site [chemical binding]; other site 454166011459 dimer interface [polypeptide binding]; other site 454166011460 ATP binding site [chemical binding]; other site 454166011461 transcriptional repressor RbsR; Provisional; Region: PRK10423 454166011462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166011463 DNA binding site [nucleotide binding] 454166011464 domain linker motif; other site 454166011465 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 454166011466 dimerization interface [polypeptide binding]; other site 454166011467 ligand binding site [chemical binding]; other site 454166011468 putative transporter; Provisional; Region: PRK10504 454166011469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011470 putative substrate translocation pore; other site 454166011471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011472 Transcriptional regulators [Transcription]; Region: FadR; COG2186 454166011473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166011474 DNA-binding site [nucleotide binding]; DNA binding site 454166011475 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454166011476 transcriptional regulator HdfR; Provisional; Region: PRK03601 454166011477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166011478 LysR substrate binding domain; Region: LysR_substrate; pfam03466 454166011479 dimerization interface [polypeptide binding]; other site 454166011480 hypothetical protein; Provisional; Region: PRK11027 454166011481 putative ATP-dependent protease; Provisional; Region: PRK09862 454166011482 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 454166011483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166011484 Walker A motif; other site 454166011485 ATP binding site [chemical binding]; other site 454166011486 Walker B motif; other site 454166011487 arginine finger; other site 454166011488 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 454166011489 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 454166011490 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454166011491 PYR/PP interface [polypeptide binding]; other site 454166011492 dimer interface [polypeptide binding]; other site 454166011493 TPP binding site [chemical binding]; other site 454166011494 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454166011495 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 454166011496 TPP-binding site [chemical binding]; other site 454166011497 dimer interface [polypeptide binding]; other site 454166011498 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 454166011499 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 454166011500 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 454166011501 homodimer interface [polypeptide binding]; other site 454166011502 substrate-cofactor binding pocket; other site 454166011503 catalytic residue [active] 454166011504 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 454166011505 threonine dehydratase; Reviewed; Region: PRK09224 454166011506 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 454166011507 tetramer interface [polypeptide binding]; other site 454166011508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166011509 catalytic residue [active] 454166011510 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 454166011511 putative Ile/Val binding site [chemical binding]; other site 454166011512 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 454166011513 putative Ile/Val binding site [chemical binding]; other site 454166011514 Phage-related protein [Function unknown]; Region: COG4679 454166011515 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 454166011516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166011517 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 454166011518 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 454166011519 putative dimerization interface [polypeptide binding]; other site 454166011520 ketol-acid reductoisomerase; Validated; Region: PRK05225 454166011521 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 454166011522 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 454166011523 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 454166011524 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 454166011525 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 454166011526 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 454166011527 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 454166011528 ligand binding site [chemical binding]; other site 454166011529 flexible hinge region; other site 454166011530 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 454166011531 uridine phosphorylase; Provisional; Region: PRK11178 454166011532 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 454166011533 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 454166011534 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 454166011535 Part of AAA domain; Region: AAA_19; pfam13245 454166011536 Family description; Region: UvrD_C_2; pfam13538 454166011537 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 454166011538 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 454166011539 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 454166011540 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 454166011541 ATP binding site [chemical binding]; other site 454166011542 Mg++ binding site [ion binding]; other site 454166011543 motif III; other site 454166011544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166011545 nucleotide binding region [chemical binding]; other site 454166011546 ATP-binding site [chemical binding]; other site 454166011547 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 454166011548 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 454166011549 catalytic residues [active] 454166011550 transcription termination factor Rho; Provisional; Region: rho; PRK09376 454166011551 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 454166011552 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 454166011553 RNA binding site [nucleotide binding]; other site 454166011554 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 454166011555 multimer interface [polypeptide binding]; other site 454166011556 Walker A motif; other site 454166011557 ATP binding site [chemical binding]; other site 454166011558 Walker B motif; other site 454166011559 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 454166011560 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 454166011561 Mg++ binding site [ion binding]; other site 454166011562 putative catalytic motif [active] 454166011563 substrate binding site [chemical binding]; other site 454166011564 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 454166011565 Chain length determinant protein; Region: Wzz; pfam02706 454166011566 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 454166011567 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 454166011568 active site 454166011569 homodimer interface [polypeptide binding]; other site 454166011570 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 454166011571 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 454166011572 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 454166011573 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 454166011574 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 454166011575 NAD binding site [chemical binding]; other site 454166011576 substrate binding site [chemical binding]; other site 454166011577 homodimer interface [polypeptide binding]; other site 454166011578 active site 454166011579 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 454166011580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 454166011581 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 454166011582 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 454166011583 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 454166011584 inhibitor-cofactor binding pocket; inhibition site 454166011585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166011586 catalytic residue [active] 454166011587 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 454166011588 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 454166011589 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 454166011590 putative common antigen polymerase; Provisional; Region: PRK02975 454166011591 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 454166011592 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 454166011593 putative transport protein YifK; Provisional; Region: PRK10746 454166011594 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 454166011595 HemY protein N-terminus; Region: HemY_N; pfam07219 454166011596 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 454166011597 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 454166011598 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 454166011599 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 454166011600 active site 454166011601 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 454166011602 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 454166011603 domain interfaces; other site 454166011604 active site 454166011605 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 454166011606 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 454166011607 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 454166011608 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 454166011609 putative iron binding site [ion binding]; other site 454166011610 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 454166011611 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 454166011612 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 454166011613 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 454166011614 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 454166011615 hypothetical protein; Provisional; Region: PRK10963 454166011616 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 454166011617 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 454166011618 active site 454166011619 Int/Topo IB signature motif; other site 454166011620 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 454166011621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011622 motif II; other site 454166011623 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 454166011624 Part of AAA domain; Region: AAA_19; pfam13245 454166011625 Family description; Region: UvrD_C_2; pfam13538 454166011626 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 454166011627 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 454166011628 Cl binding site [ion binding]; other site 454166011629 oligomer interface [polypeptide binding]; other site 454166011630 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 454166011631 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 454166011632 EamA-like transporter family; Region: EamA; cl17759 454166011633 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 454166011634 CoenzymeA binding site [chemical binding]; other site 454166011635 subunit interaction site [polypeptide binding]; other site 454166011636 PHB binding site; other site 454166011637 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 454166011638 dimerization interface [polypeptide binding]; other site 454166011639 substrate binding site [chemical binding]; other site 454166011640 active site 454166011641 calcium binding site [ion binding]; other site 454166011642 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 454166011643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166011644 ATP binding site [chemical binding]; other site 454166011645 putative Mg++ binding site [ion binding]; other site 454166011646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 454166011647 nucleotide binding region [chemical binding]; other site 454166011648 ATP-binding site [chemical binding]; other site 454166011649 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 454166011650 Helicase and RNase D C-terminal; Region: HRDC; smart00341 454166011651 threonine efflux system; Provisional; Region: PRK10229 454166011652 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 454166011653 lysophospholipase L2; Provisional; Region: PRK10749 454166011654 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 454166011655 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 454166011656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166011657 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 454166011658 putative dimerization interface [polypeptide binding]; other site 454166011659 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 454166011660 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 454166011661 THF binding site; other site 454166011662 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 454166011663 substrate binding site [chemical binding]; other site 454166011664 THF binding site; other site 454166011665 zinc-binding site [ion binding]; other site 454166011666 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 454166011667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166011668 FeS/SAM binding site; other site 454166011669 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 454166011670 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 454166011671 uridine phosphorylase; Provisional; Region: PRK11178 454166011672 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 454166011673 DNA recombination protein RmuC; Provisional; Region: PRK10361 454166011674 RmuC family; Region: RmuC; pfam02646 454166011675 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 454166011676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166011677 S-adenosylmethionine binding site [chemical binding]; other site 454166011678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 454166011679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 454166011680 SCP-2 sterol transfer family; Region: SCP2; pfam02036 454166011681 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 454166011682 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 454166011683 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 454166011684 sec-independent translocase; Provisional; Region: PRK01770 454166011685 sec-independent translocase; Provisional; Region: tatB; PRK00404 454166011686 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 454166011687 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 454166011688 active site 454166011689 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 454166011690 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 454166011691 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 454166011692 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 454166011693 FMN reductase; Validated; Region: fre; PRK08051 454166011694 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 454166011695 FAD binding pocket [chemical binding]; other site 454166011696 FAD binding motif [chemical binding]; other site 454166011697 phosphate binding motif [ion binding]; other site 454166011698 beta-alpha-beta structure motif; other site 454166011699 NAD binding pocket [chemical binding]; other site 454166011700 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454166011701 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 454166011702 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 454166011703 dimer interface [polypeptide binding]; other site 454166011704 active site 454166011705 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 454166011706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 454166011707 substrate binding site [chemical binding]; other site 454166011708 oxyanion hole (OAH) forming residues; other site 454166011709 trimer interface [polypeptide binding]; other site 454166011710 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 454166011711 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 454166011712 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 454166011713 proline dipeptidase; Provisional; Region: PRK13607 454166011714 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 454166011715 active site 454166011716 hypothetical protein; Provisional; Region: PRK11568 454166011717 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 454166011718 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 454166011719 potassium transporter; Provisional; Region: PRK10750 454166011720 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 454166011721 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 454166011722 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 454166011723 Walker A motif; other site 454166011724 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 454166011725 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 454166011726 GTP binding site; other site 454166011727 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 454166011728 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 454166011729 serine/threonine protein kinase; Provisional; Region: PRK11768 454166011730 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 454166011731 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 454166011732 catalytic residues [active] 454166011733 hinge region; other site 454166011734 alpha helical domain; other site 454166011735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 454166011736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 454166011737 putative acyl-acceptor binding pocket; other site 454166011738 DNA polymerase I; Provisional; Region: PRK05755 454166011739 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 454166011740 active site 454166011741 metal binding site 1 [ion binding]; metal-binding site 454166011742 putative 5' ssDNA interaction site; other site 454166011743 metal binding site 3; metal-binding site 454166011744 metal binding site 2 [ion binding]; metal-binding site 454166011745 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 454166011746 putative DNA binding site [nucleotide binding]; other site 454166011747 putative metal binding site [ion binding]; other site 454166011748 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 454166011749 active site 454166011750 catalytic site [active] 454166011751 substrate binding site [chemical binding]; other site 454166011752 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 454166011753 active site 454166011754 DNA binding site [nucleotide binding] 454166011755 catalytic site [active] 454166011756 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 454166011757 G1 box; other site 454166011758 GTP/Mg2+ binding site [chemical binding]; other site 454166011759 Switch I region; other site 454166011760 G2 box; other site 454166011761 G3 box; other site 454166011762 Switch II region; other site 454166011763 G4 box; other site 454166011764 G5 box; other site 454166011765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 454166011766 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 454166011767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166011768 FeS/SAM binding site; other site 454166011769 HemN C-terminal domain; Region: HemN_C; pfam06969 454166011770 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 454166011771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166011772 active site 454166011773 phosphorylation site [posttranslational modification] 454166011774 intermolecular recognition site; other site 454166011775 dimerization interface [polypeptide binding]; other site 454166011776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166011777 Walker A motif; other site 454166011778 ATP binding site [chemical binding]; other site 454166011779 Walker B motif; other site 454166011780 arginine finger; other site 454166011781 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454166011782 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 454166011783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 454166011784 putative active site [active] 454166011785 heme pocket [chemical binding]; other site 454166011786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166011787 dimer interface [polypeptide binding]; other site 454166011788 phosphorylation site [posttranslational modification] 454166011789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166011790 ATP binding site [chemical binding]; other site 454166011791 Mg2+ binding site [ion binding]; other site 454166011792 G-X-G motif; other site 454166011793 glutamine synthetase; Provisional; Region: glnA; PRK09469 454166011794 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 454166011795 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 454166011796 GTP-binding protein; Provisional; Region: PRK10218 454166011797 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 454166011798 G1 box; other site 454166011799 putative GEF interaction site [polypeptide binding]; other site 454166011800 GTP/Mg2+ binding site [chemical binding]; other site 454166011801 Switch I region; other site 454166011802 G2 box; other site 454166011803 G3 box; other site 454166011804 Switch II region; other site 454166011805 G4 box; other site 454166011806 G5 box; other site 454166011807 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 454166011808 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 454166011809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011810 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 454166011811 active site 454166011812 motif I; other site 454166011813 motif II; other site 454166011814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011815 coproporphyrinogen III oxidase; Validated; Region: PRK08208 454166011816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166011817 FeS/SAM binding site; other site 454166011818 HemN C-terminal domain; Region: HemN_C; pfam06969 454166011819 Sulfatase; Region: Sulfatase; cl17466 454166011820 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 454166011821 outer membrane porin L; Provisional; Region: ompL; PRK09980 454166011822 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 454166011823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011824 putative substrate translocation pore; other site 454166011825 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 454166011826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166011827 putative substrate translocation pore; other site 454166011828 alpha-glucosidase; Provisional; Region: PRK10426 454166011829 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 454166011830 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 454166011831 putative active site [active] 454166011832 putative catalytic site [active] 454166011833 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 454166011834 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 454166011835 active site 454166011836 catalytic residues [active] 454166011837 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 454166011838 dimerization interface [polypeptide binding]; other site 454166011839 putative active cleft [active] 454166011840 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 454166011841 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 454166011842 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 454166011843 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166011844 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 454166011845 substrate binding site [chemical binding]; other site 454166011846 ATP binding site [chemical binding]; other site 454166011847 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 454166011848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 454166011849 putative DNA binding site [nucleotide binding]; other site 454166011850 putative Zn2+ binding site [ion binding]; other site 454166011851 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166011852 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 454166011853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166011854 motif II; other site 454166011855 hypothetical protein; Reviewed; Region: PRK01637 454166011856 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 454166011857 putative active site [active] 454166011858 dimerization interface [polypeptide binding]; other site 454166011859 putative tRNAtyr binding site [nucleotide binding]; other site 454166011860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166011861 Coenzyme A binding pocket [chemical binding]; other site 454166011862 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 454166011863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166011864 non-specific DNA binding site [nucleotide binding]; other site 454166011865 salt bridge; other site 454166011866 sequence-specific DNA binding site [nucleotide binding]; other site 454166011867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 454166011868 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 454166011869 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 454166011870 substrate binding pocket [chemical binding]; other site 454166011871 Predicted transcriptional regulator [Transcription]; Region: COG2944 454166011872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166011873 non-specific DNA binding site [nucleotide binding]; other site 454166011874 salt bridge; other site 454166011875 sequence-specific DNA binding site [nucleotide binding]; other site 454166011876 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 454166011877 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 454166011878 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 454166011879 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 454166011880 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 454166011881 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 454166011882 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 454166011883 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 454166011884 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 454166011885 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 454166011886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 454166011887 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 454166011888 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 454166011889 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 454166011890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166011891 non-specific DNA binding site [nucleotide binding]; other site 454166011892 salt bridge; other site 454166011893 sequence-specific DNA binding site [nucleotide binding]; other site 454166011894 Cupin domain; Region: Cupin_2; cl17218 454166011895 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 454166011896 lactaldehyde reductase; Region: lactal_redase; TIGR02638 454166011897 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 454166011898 dimer interface [polypeptide binding]; other site 454166011899 active site 454166011900 metal binding site [ion binding]; metal-binding site 454166011901 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454166011902 intersubunit interface [polypeptide binding]; other site 454166011903 active site 454166011904 Zn2+ binding site [ion binding]; other site 454166011905 L-rhamnose isomerase; Provisional; Region: PRK01076 454166011906 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 454166011907 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 454166011908 N- and C-terminal domain interface [polypeptide binding]; other site 454166011909 active site 454166011910 putative catalytic site [active] 454166011911 metal binding site [ion binding]; metal-binding site 454166011912 ATP binding site [chemical binding]; other site 454166011913 rhamnulokinase; Provisional; Region: rhaB; PRK10640 454166011914 carbohydrate binding site [chemical binding]; other site 454166011915 transcriptional activator RhaS; Provisional; Region: PRK13503 454166011916 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454166011917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166011918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166011919 transcriptional activator RhaR; Provisional; Region: PRK13502 454166011920 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454166011921 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166011922 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 454166011923 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 454166011924 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 454166011925 DctM-like transporters; Region: DctM; pfam06808 454166011926 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 454166011927 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 454166011928 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 454166011929 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 454166011930 superoxide dismutase; Provisional; Region: PRK10925 454166011931 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 454166011932 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 454166011933 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 454166011934 MOSC domain; Region: MOSC; pfam03473 454166011935 3-alpha domain; Region: 3-alpha; pfam03475 454166011936 SnoaL-like domain; Region: SnoaL_2; pfam12680 454166011937 two-component sensor protein; Provisional; Region: cpxA; PRK09470 454166011938 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 454166011939 dimerization interface [polypeptide binding]; other site 454166011940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166011941 dimer interface [polypeptide binding]; other site 454166011942 phosphorylation site [posttranslational modification] 454166011943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166011944 ATP binding site [chemical binding]; other site 454166011945 Mg2+ binding site [ion binding]; other site 454166011946 G-X-G motif; other site 454166011947 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 454166011948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166011949 active site 454166011950 intermolecular recognition site; other site 454166011951 dimerization interface [polypeptide binding]; other site 454166011952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166011953 DNA binding site [nucleotide binding] 454166011954 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454166011955 dimer interface [polypeptide binding]; other site 454166011956 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 454166011957 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 454166011958 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 454166011959 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 454166011960 active site 454166011961 ADP/pyrophosphate binding site [chemical binding]; other site 454166011962 dimerization interface [polypeptide binding]; other site 454166011963 allosteric effector site; other site 454166011964 fructose-1,6-bisphosphate binding site; other site 454166011965 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 454166011966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166011967 substrate binding pocket [chemical binding]; other site 454166011968 membrane-bound complex binding site; other site 454166011969 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 454166011970 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 454166011971 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166011972 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 454166011973 putative substrate binding site [chemical binding]; other site 454166011974 putative ATP binding site [chemical binding]; other site 454166011975 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 454166011976 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 454166011977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166011978 DNA-binding site [nucleotide binding]; DNA binding site 454166011979 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 454166011980 UTRA domain; Region: UTRA; pfam07702 454166011981 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 454166011982 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 454166011983 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 454166011984 putative N- and C-terminal domain interface [polypeptide binding]; other site 454166011985 putative active site [active] 454166011986 putative MgATP binding site [chemical binding]; other site 454166011987 catalytic site [active] 454166011988 metal binding site [ion binding]; metal-binding site 454166011989 putative carbohydrate binding site [chemical binding]; other site 454166011990 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 454166011991 transcriptional regulator LsrR; Provisional; Region: PRK15418 454166011992 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 454166011993 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 454166011994 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 454166011995 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 454166011996 Walker A/P-loop; other site 454166011997 ATP binding site [chemical binding]; other site 454166011998 Q-loop/lid; other site 454166011999 ABC transporter signature motif; other site 454166012000 Walker B; other site 454166012001 D-loop; other site 454166012002 H-loop/switch region; other site 454166012003 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 454166012004 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454166012005 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454166012006 TM-ABC transporter signature motif; other site 454166012007 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 454166012008 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 454166012009 TM-ABC transporter signature motif; other site 454166012010 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 454166012011 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 454166012012 ligand binding site [chemical binding]; other site 454166012013 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 454166012014 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 454166012015 putative active site; other site 454166012016 catalytic residue [active] 454166012017 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 454166012018 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 454166012019 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454166012020 substrate binding site [chemical binding]; other site 454166012021 hexamer interface [polypeptide binding]; other site 454166012022 metal binding site [ion binding]; metal-binding site 454166012023 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 454166012024 triosephosphate isomerase; Provisional; Region: PRK14567 454166012025 substrate binding site [chemical binding]; other site 454166012026 dimer interface [polypeptide binding]; other site 454166012027 catalytic triad [active] 454166012028 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 454166012029 Predicted membrane protein [Function unknown]; Region: COG3152 454166012030 ferredoxin-NADP reductase; Provisional; Region: PRK10926 454166012031 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 454166012032 FAD binding pocket [chemical binding]; other site 454166012033 FAD binding motif [chemical binding]; other site 454166012034 phosphate binding motif [ion binding]; other site 454166012035 beta-alpha-beta structure motif; other site 454166012036 NAD binding pocket [chemical binding]; other site 454166012037 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 454166012038 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 454166012039 putative active site [active] 454166012040 glycerol kinase; Provisional; Region: glpK; PRK00047 454166012041 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 454166012042 N- and C-terminal domain interface [polypeptide binding]; other site 454166012043 active site 454166012044 MgATP binding site [chemical binding]; other site 454166012045 catalytic site [active] 454166012046 metal binding site [ion binding]; metal-binding site 454166012047 glycerol binding site [chemical binding]; other site 454166012048 homotetramer interface [polypeptide binding]; other site 454166012049 homodimer interface [polypeptide binding]; other site 454166012050 FBP binding site [chemical binding]; other site 454166012051 protein IIAGlc interface [polypeptide binding]; other site 454166012052 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 454166012053 amphipathic channel; other site 454166012054 Asn-Pro-Ala signature motifs; other site 454166012055 septal ring assembly protein ZapB; Provisional; Region: PRK15422 454166012056 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 454166012057 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 454166012058 UbiA prenyltransferase family; Region: UbiA; pfam01040 454166012059 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 454166012060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166012061 Walker A motif; other site 454166012062 ATP binding site [chemical binding]; other site 454166012063 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 454166012064 Walker B motif; other site 454166012065 arginine finger; other site 454166012066 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 454166012067 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 454166012068 active site 454166012069 HslU subunit interaction site [polypeptide binding]; other site 454166012070 essential cell division protein FtsN; Provisional; Region: PRK10927 454166012071 cell division protein FtsN; Provisional; Region: PRK12757 454166012072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166012073 DNA binding site [nucleotide binding] 454166012074 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 454166012075 domain linker motif; other site 454166012076 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 454166012077 dimerization interface [polypeptide binding]; other site 454166012078 ligand binding site [chemical binding]; other site 454166012079 primosome assembly protein PriA; Validated; Region: PRK05580 454166012080 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166012081 ATP binding site [chemical binding]; other site 454166012082 putative Mg++ binding site [ion binding]; other site 454166012083 helicase superfamily c-terminal domain; Region: HELICc; smart00490 454166012084 ATP-binding site [chemical binding]; other site 454166012085 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 454166012086 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 454166012087 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 454166012088 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 454166012089 dimerization interface [polypeptide binding]; other site 454166012090 DNA binding site [nucleotide binding] 454166012091 corepressor binding sites; other site 454166012092 cystathionine gamma-synthase; Provisional; Region: PRK08045 454166012093 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 454166012094 homodimer interface [polypeptide binding]; other site 454166012095 substrate-cofactor binding pocket; other site 454166012096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166012097 catalytic residue [active] 454166012098 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 454166012099 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 454166012100 putative catalytic residues [active] 454166012101 putative nucleotide binding site [chemical binding]; other site 454166012102 putative aspartate binding site [chemical binding]; other site 454166012103 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 454166012104 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 454166012105 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 454166012106 mechanosensitive channel MscS; Provisional; Region: PRK10334 454166012107 Conserved TM helix; Region: TM_helix; pfam05552 454166012108 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166012109 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 454166012110 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 454166012111 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 454166012112 active site 454166012113 metal binding site [ion binding]; metal-binding site 454166012114 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 454166012115 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 454166012116 FAD binding site [chemical binding]; other site 454166012117 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 454166012118 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 454166012119 heme binding site [chemical binding]; other site 454166012120 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 454166012121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 454166012122 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 454166012123 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 454166012124 dimer interface [polypeptide binding]; other site 454166012125 active site 454166012126 metal binding site [ion binding]; metal-binding site 454166012127 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 454166012128 active site 454166012129 intersubunit interactions; other site 454166012130 catalytic residue [active] 454166012131 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166012132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166012133 hypothetical protein; Provisional; Region: PRK10649 454166012134 Sulfatase; Region: Sulfatase; pfam00884 454166012135 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 454166012136 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 454166012137 acetylornithine deacetylase; Provisional; Region: PRK05111 454166012138 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 454166012139 metal binding site [ion binding]; metal-binding site 454166012140 putative dimer interface [polypeptide binding]; other site 454166012141 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 454166012142 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 454166012143 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 454166012144 nucleotide binding site [chemical binding]; other site 454166012145 N-acetyl-L-glutamate binding site [chemical binding]; other site 454166012146 argininosuccinate lyase; Provisional; Region: PRK04833 454166012147 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 454166012148 active sites [active] 454166012149 tetramer interface [polypeptide binding]; other site 454166012150 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 454166012151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166012152 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 454166012153 dimerization interface [polypeptide binding]; other site 454166012154 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 454166012155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 454166012156 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 454166012157 hypothetical protein; Provisional; Region: PRK11056 454166012158 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 454166012159 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 454166012160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166012161 S-adenosylmethionine binding site [chemical binding]; other site 454166012162 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 454166012163 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 454166012164 N-terminal plug; other site 454166012165 ligand-binding site [chemical binding]; other site 454166012166 glutamate racemase; Provisional; Region: PRK00865 454166012167 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 454166012168 FAD binding domain; Region: FAD_binding_4; pfam01565 454166012169 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 454166012170 Biotin operon repressor [Transcription]; Region: BirA; COG1654 454166012171 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 454166012172 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 454166012173 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 454166012174 pantothenate kinase; Provisional; Region: PRK05439 454166012175 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 454166012176 ATP-binding site [chemical binding]; other site 454166012177 CoA-binding site [chemical binding]; other site 454166012178 Mg2+-binding site [ion binding]; other site 454166012179 elongation factor Tu; Reviewed; Region: PRK00049 454166012180 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 454166012181 G1 box; other site 454166012182 GEF interaction site [polypeptide binding]; other site 454166012183 GTP/Mg2+ binding site [chemical binding]; other site 454166012184 Switch I region; other site 454166012185 G2 box; other site 454166012186 G3 box; other site 454166012187 Switch II region; other site 454166012188 G4 box; other site 454166012189 G5 box; other site 454166012190 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 454166012191 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 454166012192 Antibiotic Binding Site [chemical binding]; other site 454166012193 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 454166012194 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 454166012195 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 454166012196 putative homodimer interface [polypeptide binding]; other site 454166012197 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 454166012198 heterodimer interface [polypeptide binding]; other site 454166012199 homodimer interface [polypeptide binding]; other site 454166012200 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 454166012201 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 454166012202 23S rRNA interface [nucleotide binding]; other site 454166012203 L7/L12 interface [polypeptide binding]; other site 454166012204 putative thiostrepton binding site; other site 454166012205 L25 interface [polypeptide binding]; other site 454166012206 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 454166012207 mRNA/rRNA interface [nucleotide binding]; other site 454166012208 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 454166012209 23S rRNA interface [nucleotide binding]; other site 454166012210 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 454166012211 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 454166012212 core dimer interface [polypeptide binding]; other site 454166012213 peripheral dimer interface [polypeptide binding]; other site 454166012214 L10 interface [polypeptide binding]; other site 454166012215 L11 interface [polypeptide binding]; other site 454166012216 putative EF-Tu interaction site [polypeptide binding]; other site 454166012217 putative EF-G interaction site [polypeptide binding]; other site 454166012218 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 454166012219 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 454166012220 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 454166012221 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 454166012222 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 454166012223 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 454166012224 RPB3 interaction site [polypeptide binding]; other site 454166012225 RPB1 interaction site [polypeptide binding]; other site 454166012226 RPB11 interaction site [polypeptide binding]; other site 454166012227 RPB10 interaction site [polypeptide binding]; other site 454166012228 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 454166012229 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 454166012230 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 454166012231 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 454166012232 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 454166012233 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 454166012234 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 454166012235 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 454166012236 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 454166012237 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 454166012238 DNA binding site [nucleotide binding] 454166012239 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 454166012240 type III secretion system protein; Provisional; Region: PRK15384 454166012241 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 454166012242 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 454166012243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166012244 FeS/SAM binding site; other site 454166012245 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 454166012246 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 454166012247 ThiS interaction site; other site 454166012248 putative active site [active] 454166012249 tetramer interface [polypeptide binding]; other site 454166012250 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 454166012251 thiS-thiF/thiG interaction site; other site 454166012252 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 454166012253 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 454166012254 ATP binding site [chemical binding]; other site 454166012255 substrate interface [chemical binding]; other site 454166012256 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 454166012257 thiamine phosphate binding site [chemical binding]; other site 454166012258 active site 454166012259 pyrophosphate binding site [ion binding]; other site 454166012260 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 454166012261 ThiC-associated domain; Region: ThiC-associated; pfam13667 454166012262 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 454166012263 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 454166012264 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 454166012265 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 454166012266 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 454166012267 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 454166012268 putative NADH binding site [chemical binding]; other site 454166012269 putative active site [active] 454166012270 nudix motif; other site 454166012271 putative metal binding site [ion binding]; other site 454166012272 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 454166012273 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 454166012274 substrate binding site [chemical binding]; other site 454166012275 active site 454166012276 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 454166012277 Active_site [active] 454166012278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 454166012279 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 454166012280 IHF dimer interface [polypeptide binding]; other site 454166012281 IHF - DNA interface [nucleotide binding]; other site 454166012282 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 454166012283 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 454166012284 dimer interface [polypeptide binding]; other site 454166012285 sensor protein ZraS; Provisional; Region: PRK10364 454166012286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166012287 dimer interface [polypeptide binding]; other site 454166012288 phosphorylation site [posttranslational modification] 454166012289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166012290 ATP binding site [chemical binding]; other site 454166012291 Mg2+ binding site [ion binding]; other site 454166012292 G-X-G motif; other site 454166012293 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 454166012294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166012295 active site 454166012296 phosphorylation site [posttranslational modification] 454166012297 intermolecular recognition site; other site 454166012298 dimerization interface [polypeptide binding]; other site 454166012299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166012300 Walker A motif; other site 454166012301 ATP binding site [chemical binding]; other site 454166012302 Walker B motif; other site 454166012303 arginine finger; other site 454166012304 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 454166012305 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 454166012306 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 454166012307 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 454166012308 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 454166012309 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 454166012310 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 454166012311 purine monophosphate binding site [chemical binding]; other site 454166012312 dimer interface [polypeptide binding]; other site 454166012313 putative catalytic residues [active] 454166012314 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 454166012315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 454166012316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166012317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 454166012318 Coenzyme A binding pocket [chemical binding]; other site 454166012319 homoserine O-succinyltransferase; Provisional; Region: PRK05368 454166012320 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 454166012321 proposed active site lysine [active] 454166012322 conserved cys residue [active] 454166012323 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 454166012324 malate synthase A; Region: malate_syn_A; TIGR01344 454166012325 active site 454166012326 isocitrate lyase; Provisional; Region: PRK15063 454166012327 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 454166012328 tetramer interface [polypeptide binding]; other site 454166012329 active site 454166012330 Mg2+/Mn2+ binding site [ion binding]; other site 454166012331 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 454166012332 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 454166012333 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 454166012334 transcriptional repressor IclR; Provisional; Region: PRK11569 454166012335 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 454166012336 Bacterial transcriptional regulator; Region: IclR; pfam01614 454166012337 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 454166012338 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 454166012339 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 454166012340 substrate binding pocket [chemical binding]; other site 454166012341 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 454166012342 B12 binding site [chemical binding]; other site 454166012343 cobalt ligand [ion binding]; other site 454166012344 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 454166012345 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 454166012346 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 454166012347 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 454166012348 active site pocket [active] 454166012349 oxyanion hole [active] 454166012350 catalytic triad [active] 454166012351 active site nucleophile [active] 454166012352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 454166012353 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 454166012354 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 454166012355 RNA binding surface [nucleotide binding]; other site 454166012356 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 454166012357 probable active site [active] 454166012358 hypothetical protein; Provisional; Region: PRK10515 454166012359 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 454166012360 Sodium Bile acid symporter family; Region: SBF; pfam01758 454166012361 Protein of unknown function (DUF1105); Region: DUF1105; cl05833 454166012362 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 454166012363 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 454166012364 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 454166012365 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 454166012366 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 454166012367 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 454166012368 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 454166012369 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 454166012370 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 454166012371 Ligand binding site; other site 454166012372 Putative Catalytic site; other site 454166012373 DXD motif; other site 454166012374 Predicted membrane protein [Function unknown]; Region: COG2246 454166012375 GtrA-like protein; Region: GtrA; pfam04138 454166012376 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 454166012377 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 454166012378 Phage protein D [General function prediction only]; Region: COG3500 454166012379 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 454166012380 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 454166012381 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 454166012382 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 454166012383 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 454166012384 Phage tail tube protein FII [General function prediction only]; Region: COG3498 454166012385 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 454166012386 Gp37 protein; Region: Gp37; pfam09646 454166012387 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166012388 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166012389 catalytic residue [active] 454166012390 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 454166012391 Mor transcription activator family; Region: Mor; pfam08765 454166012392 aspartate kinase III; Validated; Region: PRK09084 454166012393 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 454166012394 nucleotide binding site [chemical binding]; other site 454166012395 substrate binding site [chemical binding]; other site 454166012396 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 454166012397 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 454166012398 dimer interface [polypeptide binding]; other site 454166012399 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 454166012400 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 454166012401 active site 454166012402 dimer interface [polypeptide binding]; other site 454166012403 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 454166012404 dimer interface [polypeptide binding]; other site 454166012405 active site 454166012406 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 454166012407 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 454166012408 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 454166012409 Predicted membrane protein [Function unknown]; Region: COG3223 454166012410 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 454166012411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166012412 dimer interface [polypeptide binding]; other site 454166012413 conserved gate region; other site 454166012414 putative PBP binding loops; other site 454166012415 ABC-ATPase subunit interface; other site 454166012416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 454166012417 dimer interface [polypeptide binding]; other site 454166012418 conserved gate region; other site 454166012419 putative PBP binding loops; other site 454166012420 ABC-ATPase subunit interface; other site 454166012421 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 454166012422 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 454166012423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 454166012424 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 454166012425 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 454166012426 Walker A/P-loop; other site 454166012427 ATP binding site [chemical binding]; other site 454166012428 Q-loop/lid; other site 454166012429 ABC transporter signature motif; other site 454166012430 Walker B; other site 454166012431 D-loop; other site 454166012432 H-loop/switch region; other site 454166012433 TOBE domain; Region: TOBE_2; pfam08402 454166012434 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 454166012435 trimer interface; other site 454166012436 sugar binding site [chemical binding]; other site 454166012437 maltose regulon periplasmic protein; Provisional; Region: PRK10564 454166012438 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 454166012439 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 454166012440 UbiA prenyltransferase family; Region: UbiA; pfam01040 454166012441 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 454166012442 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 454166012443 putative acyl-acceptor binding pocket; other site 454166012444 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 454166012445 LexA repressor; Validated; Region: PRK00215 454166012446 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 454166012447 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 454166012448 Catalytic site [active] 454166012449 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 454166012450 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 454166012451 hypothetical protein; Provisional; Region: PRK10428 454166012452 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 454166012453 metal binding site 2 [ion binding]; metal-binding site 454166012454 putative DNA binding helix; other site 454166012455 metal binding site 1 [ion binding]; metal-binding site 454166012456 dimer interface [polypeptide binding]; other site 454166012457 structural Zn2+ binding site [ion binding]; other site 454166012458 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 454166012459 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 454166012460 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 454166012461 FMN binding site [chemical binding]; other site 454166012462 active site 454166012463 catalytic residues [active] 454166012464 substrate binding site [chemical binding]; other site 454166012465 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 454166012466 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 454166012467 NADP binding site [chemical binding]; other site 454166012468 dimer interface [polypeptide binding]; other site 454166012469 replicative DNA helicase; Provisional; Region: PRK08006 454166012470 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 454166012471 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 454166012472 Walker A motif; other site 454166012473 ATP binding site [chemical binding]; other site 454166012474 Walker B motif; other site 454166012475 DNA binding loops [nucleotide binding] 454166012476 alanine racemase; Reviewed; Region: alr; PRK00053 454166012477 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 454166012478 active site 454166012479 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 454166012480 substrate binding site [chemical binding]; other site 454166012481 catalytic residues [active] 454166012482 dimer interface [polypeptide binding]; other site 454166012483 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 454166012484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 454166012485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166012486 homodimer interface [polypeptide binding]; other site 454166012487 catalytic residue [active] 454166012488 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 454166012489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166012490 active site 454166012491 motif I; other site 454166012492 motif II; other site 454166012493 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 454166012494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 454166012495 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 454166012496 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 454166012497 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 454166012498 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 454166012499 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 454166012500 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 454166012501 dimer interface [polypeptide binding]; other site 454166012502 ssDNA binding site [nucleotide binding]; other site 454166012503 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454166012504 hypothetical protein; Validated; Region: PRK09039 454166012505 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 454166012506 Outer membrane efflux protein; Region: OEP; pfam02321 454166012507 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 454166012508 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 454166012509 HlyD family secretion protein; Region: HlyD_3; pfam13437 454166012510 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012511 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012512 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012513 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012514 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012515 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454166012516 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012517 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012518 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454166012519 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012520 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012521 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012522 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012523 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454166012524 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012525 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012526 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012527 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454166012528 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012529 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012530 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012531 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012532 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012533 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012534 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 454166012535 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012536 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012537 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012538 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012539 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012540 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012541 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012542 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 454166012543 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012544 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 454166012545 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012546 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012547 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 454166012548 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 454166012549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 454166012550 Walker A/P-loop; other site 454166012551 ATP binding site [chemical binding]; other site 454166012552 Q-loop/lid; other site 454166012553 ABC transporter signature motif; other site 454166012554 Walker B; other site 454166012555 D-loop; other site 454166012556 H-loop/switch region; other site 454166012557 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 454166012558 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 454166012559 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 454166012560 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 454166012561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166012562 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 454166012563 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 454166012564 DNA binding residues [nucleotide binding] 454166012565 dimer interface [polypeptide binding]; other site 454166012566 [2Fe-2S] cluster binding site [ion binding]; other site 454166012567 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 454166012568 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 454166012569 putative C-terminal domain interface [polypeptide binding]; other site 454166012570 putative GSH binding site (G-site) [chemical binding]; other site 454166012571 putative dimer interface [polypeptide binding]; other site 454166012572 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 454166012573 putative N-terminal domain interface [polypeptide binding]; other site 454166012574 putative dimer interface [polypeptide binding]; other site 454166012575 putative substrate binding pocket (H-site) [chemical binding]; other site 454166012576 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 454166012577 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 454166012578 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 454166012579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 454166012580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166012581 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 454166012582 putative dimerization interface [polypeptide binding]; other site 454166012583 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 454166012584 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 454166012585 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 454166012586 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 454166012587 Na binding site [ion binding]; other site 454166012588 Predicted membrane protein [Function unknown]; Region: COG3162 454166012589 acetyl-CoA synthetase; Provisional; Region: PRK00174 454166012590 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 454166012591 active site 454166012592 CoA binding site [chemical binding]; other site 454166012593 acyl-activating enzyme (AAE) consensus motif; other site 454166012594 AMP binding site [chemical binding]; other site 454166012595 acetate binding site [chemical binding]; other site 454166012596 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 454166012597 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 454166012598 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 454166012599 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 454166012600 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 454166012601 heme lyase subunit NrfE; Provisional; Region: PRK10369 454166012602 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 454166012603 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 454166012604 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 454166012605 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 454166012606 Transposase; Region: DEDD_Tnp_IS110; pfam01548 454166012607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 454166012608 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 454166012609 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 454166012610 Sel1-like repeats; Region: SEL1; smart00671 454166012611 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 454166012612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166012613 Coenzyme A binding pocket [chemical binding]; other site 454166012614 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 454166012615 dimer interface [polypeptide binding]; other site 454166012616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 454166012617 hypothetical protein; Provisional; Region: PRK10220 454166012618 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 454166012619 PhnA protein; Region: PhnA; pfam03831 454166012620 proline/glycine betaine transporter; Provisional; Region: PRK10642 454166012621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166012622 putative substrate translocation pore; other site 454166012623 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 454166012624 sensor protein BasS/PmrB; Provisional; Region: PRK10755 454166012625 HAMP domain; Region: HAMP; pfam00672 454166012626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166012627 dimer interface [polypeptide binding]; other site 454166012628 phosphorylation site [posttranslational modification] 454166012629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166012630 ATP binding site [chemical binding]; other site 454166012631 Mg2+ binding site [ion binding]; other site 454166012632 G-X-G motif; other site 454166012633 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 454166012634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166012635 active site 454166012636 phosphorylation site [posttranslational modification] 454166012637 intermolecular recognition site; other site 454166012638 dimerization interface [polypeptide binding]; other site 454166012639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166012640 DNA binding site [nucleotide binding] 454166012641 putative metal dependent hydrolase; Provisional; Region: PRK11598 454166012642 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 454166012643 Sulfatase; Region: Sulfatase; pfam00884 454166012644 arginine:agmatin antiporter; Provisional; Region: PRK10644 454166012645 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 454166012646 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 454166012647 arginine decarboxylase; Provisional; Region: PRK15029 454166012648 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 454166012649 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 454166012650 homodimer interface [polypeptide binding]; other site 454166012651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 454166012652 catalytic residue [active] 454166012653 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 454166012654 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 454166012655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166012656 alpha-galactosidase; Provisional; Region: PRK15076 454166012657 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 454166012658 NAD binding site [chemical binding]; other site 454166012659 sugar binding site [chemical binding]; other site 454166012660 divalent metal binding site [ion binding]; other site 454166012661 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 454166012662 dimer interface [polypeptide binding]; other site 454166012663 melibiose:sodium symporter; Provisional; Region: PRK10429 454166012664 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 454166012665 fumarate hydratase; Provisional; Region: PRK15389 454166012666 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 454166012667 Fumarase C-terminus; Region: Fumerase_C; pfam05683 454166012668 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 454166012669 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 454166012670 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 454166012671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166012672 active site 454166012673 phosphorylation site [posttranslational modification] 454166012674 intermolecular recognition site; other site 454166012675 dimerization interface [polypeptide binding]; other site 454166012676 sensory histidine kinase DcuS; Provisional; Region: PRK11086 454166012677 PAS domain; Region: PAS; smart00091 454166012678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166012679 ATP binding site [chemical binding]; other site 454166012680 Mg2+ binding site [ion binding]; other site 454166012681 G-X-G motif; other site 454166012682 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 454166012683 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 454166012684 putative [Fe4-S4] binding site [ion binding]; other site 454166012685 putative molybdopterin cofactor binding site [chemical binding]; other site 454166012686 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 454166012687 putative molybdopterin cofactor binding site; other site 454166012688 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 454166012689 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 454166012690 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 454166012691 SdiA-regulated; Region: SdiA-regulated; pfam06977 454166012692 SdiA-regulated; Region: SdiA-regulated; cd09971 454166012693 putative active site [active] 454166012694 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454166012695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166012696 DNA binding residues [nucleotide binding] 454166012697 dimerization interface [polypeptide binding]; other site 454166012698 AraC family transcriptional regulator; Provisional; Region: PRK15186 454166012699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166012700 Integrase core domain; Region: rve; pfam00665 454166012701 Integrase core domain; Region: rve_2; pfam13333 454166012702 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 454166012703 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 454166012704 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 454166012705 active site 454166012706 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 454166012707 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454166012708 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 454166012709 putative NAD(P) binding site [chemical binding]; other site 454166012710 catalytic Zn binding site [ion binding]; other site 454166012711 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 454166012712 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 454166012713 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 454166012714 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 454166012715 putative NAD(P) binding site [chemical binding]; other site 454166012716 catalytic Zn binding site [ion binding]; other site 454166012717 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 454166012718 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 454166012719 substrate binding site [chemical binding]; other site 454166012720 hexamer interface [polypeptide binding]; other site 454166012721 metal binding site [ion binding]; metal-binding site 454166012722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166012723 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 454166012724 Walker A motif; other site 454166012725 ATP binding site [chemical binding]; other site 454166012726 Walker B motif; other site 454166012727 arginine finger; other site 454166012728 Transcriptional antiterminator [Transcription]; Region: COG3933 454166012729 PRD domain; Region: PRD; pfam00874 454166012730 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 454166012731 active site 454166012732 active pocket/dimerization site; other site 454166012733 phosphorylation site [posttranslational modification] 454166012734 PRD domain; Region: PRD; pfam00874 454166012735 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 454166012736 putative transcriptional regulator; Provisional; Region: PRK11640 454166012737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 454166012738 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 454166012739 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 454166012740 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 454166012741 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 454166012742 DsbD alpha interface [polypeptide binding]; other site 454166012743 catalytic residues [active] 454166012744 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 454166012745 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 454166012746 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 454166012747 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 454166012748 Aspartase; Region: Aspartase; cd01357 454166012749 active sites [active] 454166012750 tetramer interface [polypeptide binding]; other site 454166012751 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 454166012752 putative transporter; Provisional; Region: PRK11021 454166012753 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 454166012754 oligomerisation interface [polypeptide binding]; other site 454166012755 mobile loop; other site 454166012756 roof hairpin; other site 454166012757 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 454166012758 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 454166012759 ring oligomerisation interface [polypeptide binding]; other site 454166012760 ATP/Mg binding site [chemical binding]; other site 454166012761 stacking interactions; other site 454166012762 hinge regions; other site 454166012763 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 454166012764 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 454166012765 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166012766 FeS/SAM binding site; other site 454166012767 elongation factor P; Validated; Region: PRK00529 454166012768 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 454166012769 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 454166012770 RNA binding site [nucleotide binding]; other site 454166012771 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 454166012772 RNA binding site [nucleotide binding]; other site 454166012773 Predicted small secreted protein [Function unknown]; Region: COG5510 454166012774 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 454166012775 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 454166012776 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 454166012777 Iron-sulfur protein interface; other site 454166012778 proximal quinone binding site [chemical binding]; other site 454166012779 C-subunit interface; other site 454166012780 distal quinone binding site; other site 454166012781 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 454166012782 D-subunit interface [polypeptide binding]; other site 454166012783 Iron-sulfur protein interface; other site 454166012784 proximal quinone binding site [chemical binding]; other site 454166012785 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 454166012786 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 454166012787 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 454166012788 L-aspartate oxidase; Provisional; Region: PRK06175 454166012789 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 454166012790 poxB regulator PoxA; Provisional; Region: PRK09350 454166012791 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 454166012792 motif 1; other site 454166012793 dimer interface [polypeptide binding]; other site 454166012794 active site 454166012795 motif 2; other site 454166012796 motif 3; other site 454166012797 inner membrane transporter YjeM; Provisional; Region: PRK15238 454166012798 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 454166012799 putative mechanosensitive channel protein; Provisional; Region: PRK10929 454166012800 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 454166012801 Mechanosensitive ion channel; Region: MS_channel; pfam00924 454166012802 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 454166012803 GTPase RsgA; Reviewed; Region: PRK12288 454166012804 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 454166012805 RNA binding site [nucleotide binding]; other site 454166012806 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 454166012807 GTPase/Zn-binding domain interface [polypeptide binding]; other site 454166012808 GTP/Mg2+ binding site [chemical binding]; other site 454166012809 G4 box; other site 454166012810 G5 box; other site 454166012811 G1 box; other site 454166012812 Switch I region; other site 454166012813 G2 box; other site 454166012814 G3 box; other site 454166012815 Switch II region; other site 454166012816 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 454166012817 catalytic site [active] 454166012818 putative active site [active] 454166012819 putative substrate binding site [chemical binding]; other site 454166012820 dimer interface [polypeptide binding]; other site 454166012821 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 454166012822 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 454166012823 substrate binding pocket [chemical binding]; other site 454166012824 membrane-bound complex binding site; other site 454166012825 hinge residues; other site 454166012826 epoxyqueuosine reductase; Region: TIGR00276 454166012827 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 454166012828 putative carbohydrate kinase; Provisional; Region: PRK10565 454166012829 Uncharacterized conserved protein [Function unknown]; Region: COG0062 454166012830 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 454166012831 putative substrate binding site [chemical binding]; other site 454166012832 putative ATP binding site [chemical binding]; other site 454166012833 ADP-binding protein; Provisional; Region: PRK10646 454166012834 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 454166012835 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 454166012836 active site 454166012837 metal binding site [ion binding]; metal-binding site 454166012838 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 454166012839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166012840 ATP binding site [chemical binding]; other site 454166012841 Mg2+ binding site [ion binding]; other site 454166012842 G-X-G motif; other site 454166012843 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 454166012844 ATP binding site [chemical binding]; other site 454166012845 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 454166012846 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 454166012847 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 454166012848 bacterial Hfq-like; Region: Hfq; cd01716 454166012849 hexamer interface [polypeptide binding]; other site 454166012850 Sm1 motif; other site 454166012851 RNA binding site [nucleotide binding]; other site 454166012852 Sm2 motif; other site 454166012853 GTPase HflX; Provisional; Region: PRK11058 454166012854 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 454166012855 HflX GTPase family; Region: HflX; cd01878 454166012856 G1 box; other site 454166012857 GTP/Mg2+ binding site [chemical binding]; other site 454166012858 Switch I region; other site 454166012859 G2 box; other site 454166012860 G3 box; other site 454166012861 Switch II region; other site 454166012862 G4 box; other site 454166012863 G5 box; other site 454166012864 FtsH protease regulator HflK; Provisional; Region: PRK10930 454166012865 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 454166012866 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 454166012867 FtsH protease regulator HflC; Provisional; Region: PRK11029 454166012868 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 454166012869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 454166012870 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 454166012871 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 454166012872 GDP-binding site [chemical binding]; other site 454166012873 ACT binding site; other site 454166012874 IMP binding site; other site 454166012875 Predicted transcriptional regulator [Transcription]; Region: COG1959 454166012876 transcriptional repressor NsrR; Provisional; Region: PRK11014 454166012877 exoribonuclease R; Provisional; Region: PRK11642 454166012878 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 454166012879 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 454166012880 RNB domain; Region: RNB; pfam00773 454166012881 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 454166012882 RNA binding site [nucleotide binding]; other site 454166012883 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 454166012884 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 454166012885 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 454166012886 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 454166012887 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 454166012888 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 454166012889 Predicted membrane protein [Function unknown]; Region: COG3766 454166012890 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 454166012891 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 454166012892 Predicted integral membrane protein [Function unknown]; Region: COG5463 454166012893 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 454166012894 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 454166012895 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 454166012896 FAD binding site [chemical binding]; other site 454166012897 substrate binding site [chemical binding]; other site 454166012898 catalytic residues [active] 454166012899 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166012900 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 454166012901 esterase; Provisional; Region: PRK10566 454166012902 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 454166012903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 454166012904 transcriptional repressor UlaR; Provisional; Region: PRK13509 454166012905 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 454166012906 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 454166012907 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 454166012908 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 454166012909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 454166012910 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 454166012911 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 454166012912 active site 454166012913 P-loop; other site 454166012914 phosphorylation site [posttranslational modification] 454166012915 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166012916 active site 454166012917 phosphorylation site [posttranslational modification] 454166012918 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 454166012919 active site 454166012920 dimer interface [polypeptide binding]; other site 454166012921 magnesium binding site [ion binding]; other site 454166012922 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 454166012923 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 454166012924 AP (apurinic/apyrimidinic) site pocket; other site 454166012925 DNA interaction; other site 454166012926 Metal-binding active site; metal-binding site 454166012927 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 454166012928 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 454166012929 intersubunit interface [polypeptide binding]; other site 454166012930 active site 454166012931 Zn2+ binding site [ion binding]; other site 454166012932 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 454166012933 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 454166012934 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 454166012935 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 454166012936 dimer interface [polypeptide binding]; other site 454166012937 ssDNA binding site [nucleotide binding]; other site 454166012938 tetramer (dimer of dimers) interface [polypeptide binding]; other site 454166012939 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 454166012940 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 454166012941 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 454166012942 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 454166012943 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 454166012944 EamA-like transporter family; Region: EamA; pfam00892 454166012945 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 454166012946 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 454166012947 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 454166012948 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 454166012949 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 454166012950 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 454166012951 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 454166012952 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 454166012953 Hemerythrin-like domain; Region: Hr-like; cd12108 454166012954 Fe binding site [ion binding]; other site 454166012955 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 454166012956 EamA-like transporter family; Region: EamA; pfam00892 454166012957 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 454166012958 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 454166012959 NADP binding site [chemical binding]; other site 454166012960 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 454166012961 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 454166012962 active site 454166012963 metal binding site [ion binding]; metal-binding site 454166012964 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 454166012965 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 454166012966 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 454166012967 active site 454166012968 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 454166012969 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 454166012970 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 454166012971 Domain of unknown function DUF21; Region: DUF21; pfam01595 454166012972 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 454166012973 Transporter associated domain; Region: CorC_HlyC; smart01091 454166012974 methionine sulfoxide reductase A; Provisional; Region: PRK00058 454166012975 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 454166012976 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 454166012977 Surface antigen; Region: Bac_surface_Ag; pfam01103 454166012978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 454166012979 Family of unknown function (DUF490); Region: DUF490; pfam04357 454166012980 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 454166012981 putative active site pocket [active] 454166012982 dimerization interface [polypeptide binding]; other site 454166012983 putative catalytic residue [active] 454166012984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166012985 D-galactonate transporter; Region: 2A0114; TIGR00893 454166012986 putative substrate translocation pore; other site 454166012987 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 454166012988 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 454166012989 active site 454166012990 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 454166012991 dimer interface [polypeptide binding]; other site 454166012992 substrate binding site [chemical binding]; other site 454166012993 metal binding sites [ion binding]; metal-binding site 454166012994 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 454166012995 AMP binding site [chemical binding]; other site 454166012996 metal binding site [ion binding]; metal-binding site 454166012997 active site 454166012998 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 454166012999 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 454166013000 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 454166013001 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 454166013002 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 454166013003 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 454166013004 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 454166013005 putative active site [active] 454166013006 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 454166013007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166013008 putative substrate translocation pore; other site 454166013009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166013010 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 454166013011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166013012 putative substrate translocation pore; other site 454166013013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166013014 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 454166013015 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 454166013016 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 454166013017 tetrameric interface [polypeptide binding]; other site 454166013018 NAD binding site [chemical binding]; other site 454166013019 catalytic residues [active] 454166013020 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454166013021 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 454166013022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166013023 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 454166013024 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454166013025 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454166013026 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454166013027 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 454166013028 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 454166013029 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 454166013030 major facilitator superfamily transporter; Provisional; Region: PRK05122 454166013031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166013032 putative substrate translocation pore; other site 454166013033 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 454166013034 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 454166013035 substrate binding site [chemical binding]; other site 454166013036 ATP binding site [chemical binding]; other site 454166013037 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 454166013038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 454166013039 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 454166013040 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 454166013041 PYR/PP interface [polypeptide binding]; other site 454166013042 dimer interface [polypeptide binding]; other site 454166013043 TPP binding site [chemical binding]; other site 454166013044 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 454166013045 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 454166013046 TPP-binding site; other site 454166013047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 454166013048 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 454166013049 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 454166013050 polyol permease family; Region: 2A0118; TIGR00897 454166013051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166013052 putative substrate translocation pore; other site 454166013053 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 454166013054 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 454166013055 DNA interaction; other site 454166013056 Metal-binding active site; metal-binding site 454166013057 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 454166013058 hypothetical protein; Provisional; Region: PRK05255 454166013059 peptidase PmbA; Provisional; Region: PRK11040 454166013060 cytochrome b562; Provisional; Region: PRK15058 454166013061 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 454166013062 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 454166013063 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 454166013064 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 454166013065 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 454166013066 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 454166013067 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 454166013068 active site 454166013069 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 454166013070 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 454166013071 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 454166013072 HTH domain; Region: HTH_11; pfam08279 454166013073 Mga helix-turn-helix domain; Region: Mga; pfam05043 454166013074 PRD domain; Region: PRD; pfam00874 454166013075 PRD domain; Region: PRD; pfam00874 454166013076 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 454166013077 active site 454166013078 P-loop; other site 454166013079 phosphorylation site [posttranslational modification] 454166013080 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 454166013081 active site 454166013082 phosphorylation site [posttranslational modification] 454166013083 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 454166013084 oligomeric interface; other site 454166013085 putative active site [active] 454166013086 homodimer interface [polypeptide binding]; other site 454166013087 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 454166013088 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 454166013089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166013090 FeS/SAM binding site; other site 454166013091 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 454166013092 ATP cone domain; Region: ATP-cone; pfam03477 454166013093 Class III ribonucleotide reductase; Region: RNR_III; cd01675 454166013094 effector binding site; other site 454166013095 active site 454166013096 Zn binding site [ion binding]; other site 454166013097 glycine loop; other site 454166013098 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 454166013099 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 454166013100 Ca binding site [ion binding]; other site 454166013101 active site 454166013102 catalytic site [active] 454166013103 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 454166013104 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 454166013105 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 454166013106 active site turn [active] 454166013107 phosphorylation site [posttranslational modification] 454166013108 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 454166013109 trehalose repressor; Provisional; Region: treR; PRK09492 454166013110 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166013111 DNA binding site [nucleotide binding] 454166013112 domain linker motif; other site 454166013113 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 454166013114 dimerization interface [polypeptide binding]; other site 454166013115 ligand binding site [chemical binding]; other site 454166013116 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 454166013117 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 454166013118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 454166013119 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 454166013120 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 454166013121 Soluble P-type ATPase [General function prediction only]; Region: COG4087 454166013122 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 454166013123 Transposase; Region: HTH_Tnp_1; cl17663 454166013124 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 454166013125 homotrimer interaction site [polypeptide binding]; other site 454166013126 putative active site [active] 454166013127 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 454166013128 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 454166013129 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 454166013130 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 454166013131 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 454166013132 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 454166013133 Arginine repressor [Transcription]; Region: ArgR; COG1438 454166013134 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 454166013135 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 454166013136 Predicted membrane protein [Function unknown]; Region: COG1288 454166013137 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 454166013138 ornithine carbamoyltransferase; Validated; Region: PRK02102 454166013139 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 454166013140 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 454166013141 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 454166013142 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 454166013143 putative substrate binding site [chemical binding]; other site 454166013144 nucleotide binding site [chemical binding]; other site 454166013145 nucleotide binding site [chemical binding]; other site 454166013146 homodimer interface [polypeptide binding]; other site 454166013147 arginine deiminase; Provisional; Region: PRK01388 454166013148 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 454166013149 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 454166013150 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 454166013151 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 454166013152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 454166013153 RNase E inhibitor protein; Provisional; Region: PRK11191 454166013154 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 454166013155 active site 454166013156 dinuclear metal binding site [ion binding]; other site 454166013157 dimerization interface [polypeptide binding]; other site 454166013158 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 454166013159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 454166013160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166013161 Coenzyme A binding pocket [chemical binding]; other site 454166013162 Predicted membrane protein [Function unknown]; Region: COG4269 454166013163 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 454166013164 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 454166013165 HIGH motif; other site 454166013166 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 454166013167 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 454166013168 active site 454166013169 KMSKS motif; other site 454166013170 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 454166013171 tRNA binding surface [nucleotide binding]; other site 454166013172 anticodon binding site; other site 454166013173 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 454166013174 DNA polymerase III subunit chi; Validated; Region: PRK05728 454166013175 multifunctional aminopeptidase A; Provisional; Region: PRK00913 454166013176 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 454166013177 interface (dimer of trimers) [polypeptide binding]; other site 454166013178 Substrate-binding/catalytic site; other site 454166013179 Zn-binding sites [ion binding]; other site 454166013180 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 454166013181 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 454166013182 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 454166013183 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 454166013184 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 454166013185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 454166013186 DNA binding site [nucleotide binding] 454166013187 domain linker motif; other site 454166013188 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 454166013189 putative dimerization interface [polypeptide binding]; other site 454166013190 putative ligand binding site [chemical binding]; other site 454166013191 gluconate transporter; Region: gntP; TIGR00791 454166013192 fructuronate transporter; Provisional; Region: PRK10034; cl15264 454166013193 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 454166013194 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 454166013195 NADP binding site [chemical binding]; other site 454166013196 homodimer interface [polypeptide binding]; other site 454166013197 active site 454166013198 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 454166013199 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 454166013200 putative NAD(P) binding site [chemical binding]; other site 454166013201 catalytic Zn binding site [ion binding]; other site 454166013202 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 454166013203 ATP-binding site [chemical binding]; other site 454166013204 Gluconate-6-phosphate binding site [chemical binding]; other site 454166013205 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 454166013206 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 454166013207 putative NAD(P) binding site [chemical binding]; other site 454166013208 putative substrate binding site [chemical binding]; other site 454166013209 catalytic Zn binding site [ion binding]; other site 454166013210 structural Zn binding site [ion binding]; other site 454166013211 dimer interface [polypeptide binding]; other site 454166013212 integrase; Provisional; Region: PRK09692 454166013213 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 454166013214 active site 454166013215 Int/Topo IB signature motif; other site 454166013216 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 454166013217 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 454166013218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 454166013219 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 454166013220 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 454166013221 active site 454166013222 metal binding site [ion binding]; metal-binding site 454166013223 interdomain interaction site; other site 454166013224 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 454166013225 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 454166013226 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 454166013227 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 454166013228 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 454166013229 Predicted transcriptional regulator [Transcription]; Region: COG3905 454166013230 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 454166013231 CcdB protein; Region: CcdB; pfam01845 454166013232 Helix-turn-helix domain; Region: HTH_28; pfam13518 454166013233 Integrase core domain; Region: rve; pfam00665 454166013234 Integrase core domain; Region: rve_3; pfam13683 454166013235 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 454166013236 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 454166013237 active site 454166013238 catalytic residues [active] 454166013239 DNA binding site [nucleotide binding] 454166013240 Int/Topo IB signature motif; other site 454166013241 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 454166013242 nudix motif; other site 454166013243 DNA methylase; Region: N6_N4_Mtase; pfam01555 454166013244 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 454166013245 Domain of unknown function DUF87; Region: DUF87; pfam01935 454166013246 HerA helicase [Replication, recombination, and repair]; Region: COG0433 454166013247 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 454166013248 DNA-binding interface [nucleotide binding]; DNA binding site 454166013249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 454166013250 Integrase core domain; Region: rve; pfam00665 454166013251 Integrase core domain; Region: rve_3; pfam13683 454166013252 Protein of unknown function (DUF475); Region: DUF475; cl17481 454166013253 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166013254 salt bridge; other site 454166013255 non-specific DNA binding site [nucleotide binding]; other site 454166013256 sequence-specific DNA binding site [nucleotide binding]; other site 454166013257 HipA N-terminal domain; Region: couple_hipA; TIGR03071 454166013258 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 454166013259 HipA-like N-terminal domain; Region: HipA_N; pfam07805 454166013260 HipA-like C-terminal domain; Region: HipA_C; pfam07804 454166013261 Uncharacterized conserved protein [Function unknown]; Region: COG4127 454166013262 Restriction endonuclease; Region: Mrr_cat; pfam04471 454166013263 TIR domain; Region: TIR_2; pfam13676 454166013264 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 454166013265 HsdM N-terminal domain; Region: HsdM_N; pfam12161 454166013266 Methyltransferase domain; Region: Methyltransf_26; pfam13659 454166013267 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 454166013268 HsdM N-terminal domain; Region: HsdM_N; pfam12161 454166013269 Methyltransferase domain; Region: Methyltransf_26; pfam13659 454166013270 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 454166013271 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 454166013272 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 454166013273 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 454166013274 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 454166013275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 454166013276 ATP binding site [chemical binding]; other site 454166013277 putative Mg++ binding site [ion binding]; other site 454166013278 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 454166013279 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 454166013280 dimer interface [polypeptide binding]; other site 454166013281 Mn binding site [ion binding]; other site 454166013282 K binding site [ion binding]; other site 454166013283 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 454166013284 HNH endonuclease; Region: HNH_2; pfam13391 454166013285 hypothetical protein; Provisional; Region: PRK12378 454166013286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166013287 S-adenosylmethionine binding site [chemical binding]; other site 454166013288 Methyltransferase domain; Region: Methyltransf_31; pfam13847 454166013289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166013290 S-adenosylmethionine binding site [chemical binding]; other site 454166013291 hypothetical protein; Provisional; Region: PRK13687 454166013292 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 454166013293 Uncharacterized conserved protein [Function unknown]; Region: COG3439 454166013294 Dienelactone hydrolase family; Region: DLH; pfam01738 454166013295 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 454166013296 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 454166013297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 454166013298 DNA-binding site [nucleotide binding]; DNA binding site 454166013299 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 454166013300 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 454166013301 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 454166013302 active site 454166013303 HIGH motif; other site 454166013304 dimer interface [polypeptide binding]; other site 454166013305 KMSKS motif; other site 454166013306 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 454166013307 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 454166013308 aspartate racemase; Region: asp_race; TIGR00035 454166013309 cell density-dependent motility repressor; Provisional; Region: PRK10082 454166013310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 454166013311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 454166013312 dimerization interface [polypeptide binding]; other site 454166013313 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 454166013314 isoaspartyl dipeptidase; Provisional; Region: PRK10657 454166013315 dimer interface [polypeptide binding]; other site 454166013316 active site 454166013317 hypothetical protein; Provisional; Region: PRK10519 454166013318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 454166013319 Nucleoside recognition; Region: Gate; pfam07670 454166013320 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 454166013321 Predicted membrane protein [Function unknown]; Region: COG2733 454166013322 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 454166013323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 454166013324 putative substrate translocation pore; other site 454166013325 putative transposase; Provisional; Region: PRK09857 454166013326 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 454166013327 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 454166013328 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 454166013329 NAD(P) binding site [chemical binding]; other site 454166013330 catalytic residues [active] 454166013331 Protein of unknown function DUF91; Region: DUF91; cl00709 454166013332 Uncharacterized conserved protein [Function unknown]; Region: COG3586 454166013333 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 454166013334 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 454166013335 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 454166013336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166013337 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 454166013338 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 454166013339 P-loop, Walker A motif; other site 454166013340 Base recognition motif; other site 454166013341 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 454166013342 Uncharacterized small protein [Function unknown]; Region: COG2879 454166013343 carbon starvation protein A; Provisional; Region: PRK15015 454166013344 Carbon starvation protein CstA; Region: CstA; pfam02554 454166013345 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 454166013346 phosphoglycerol transferase I; Provisional; Region: PRK03776 454166013347 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 454166013348 hypothetical protein; Provisional; Region: PRK11667 454166013349 DNA replication protein DnaC; Validated; Region: PRK07952 454166013350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 454166013351 Walker A motif; other site 454166013352 ATP binding site [chemical binding]; other site 454166013353 Walker B motif; other site 454166013354 primosomal protein DnaI; Provisional; Region: PRK02854 454166013355 hypothetical protein; Provisional; Region: PRK09917 454166013356 Uncharacterized conserved protein [Function unknown]; Region: COG2966 454166013357 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 454166013358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 454166013359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166013360 DNA binding residues [nucleotide binding] 454166013361 dimerization interface [polypeptide binding]; other site 454166013362 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 454166013363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 454166013364 DNA binding residues [nucleotide binding] 454166013365 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 454166013366 putative deacylase active site [active] 454166013367 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 454166013368 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 454166013369 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 454166013370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 454166013371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 454166013372 metal binding site [ion binding]; metal-binding site 454166013373 active site 454166013374 I-site; other site 454166013375 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 454166013376 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 454166013377 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 454166013378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 454166013379 S-adenosylmethionine binding site [chemical binding]; other site 454166013380 DNA polymerase III subunit psi; Validated; Region: PRK06856 454166013381 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 454166013382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 454166013383 Coenzyme A binding pocket [chemical binding]; other site 454166013384 dUMP phosphatase; Provisional; Region: PRK09449 454166013385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166013386 motif II; other site 454166013387 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 454166013388 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 454166013389 G1 box; other site 454166013390 putative GEF interaction site [polypeptide binding]; other site 454166013391 GTP/Mg2+ binding site [chemical binding]; other site 454166013392 Switch I region; other site 454166013393 G2 box; other site 454166013394 G3 box; other site 454166013395 Switch II region; other site 454166013396 G4 box; other site 454166013397 G5 box; other site 454166013398 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 454166013399 periplasmic protein; Provisional; Region: PRK10568 454166013400 BON domain; Region: BON; pfam04972 454166013401 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 454166013402 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 454166013403 active site 454166013404 nucleophile elbow; other site 454166013405 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 454166013406 active site 454166013407 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 454166013408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 454166013409 FeS/SAM binding site; other site 454166013410 hypothetical protein; Provisional; Region: PRK10977 454166013411 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 454166013412 intersubunit interface [polypeptide binding]; other site 454166013413 active site 454166013414 catalytic residue [active] 454166013415 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 454166013416 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 454166013417 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 454166013418 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 454166013419 phosphopentomutase; Provisional; Region: PRK05362 454166013420 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 454166013421 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 454166013422 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 454166013423 hypothetical protein; Provisional; Region: PRK15301 454166013424 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 454166013425 PapC N-terminal domain; Region: PapC_N; pfam13954 454166013426 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166013427 PapC C-terminal domain; Region: PapC_C; pfam13953 454166013428 putative fimbrial chaperone protein; Provisional; Region: PRK09918 454166013429 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166013430 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166013431 hypothetical protein; Provisional; Region: PRK15302 454166013432 hypothetical protein; Provisional; Region: PRK15303 454166013433 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 454166013434 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 454166013435 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 454166013436 hypothetical protein; Provisional; Region: PRK11246 454166013437 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 454166013438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 454166013439 motif II; other site 454166013440 DNA repair protein RadA; Region: sms; TIGR00416 454166013441 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 454166013442 Walker A motif/ATP binding site; other site 454166013443 ATP binding site [chemical binding]; other site 454166013444 Walker B motif; other site 454166013445 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 454166013446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 454166013447 non-specific DNA binding site [nucleotide binding]; other site 454166013448 salt bridge; other site 454166013449 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 454166013450 sequence-specific DNA binding site [nucleotide binding]; other site 454166013451 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 454166013452 active site 454166013453 (T/H)XGH motif; other site 454166013454 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 454166013455 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 454166013456 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166013457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166013458 ABC transporter; Region: ABC_tran_2; pfam12848 454166013459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 454166013460 lytic murein transglycosylase; Provisional; Region: PRK11619 454166013461 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 454166013462 N-acetyl-D-glucosamine binding site [chemical binding]; other site 454166013463 catalytic residue [active] 454166013464 Trp operon repressor; Provisional; Region: PRK01381 454166013465 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 454166013466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 454166013467 catalytic core [active] 454166013468 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 454166013469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 454166013470 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 454166013471 hypothetical protein; Provisional; Region: PRK10756 454166013472 CreA protein; Region: CreA; pfam05981 454166013473 DNA-binding response regulator CreB; Provisional; Region: PRK11083 454166013474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166013475 active site 454166013476 phosphorylation site [posttranslational modification] 454166013477 intermolecular recognition site; other site 454166013478 dimerization interface [polypeptide binding]; other site 454166013479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166013480 DNA binding site [nucleotide binding] 454166013481 sensory histidine kinase CreC; Provisional; Region: PRK11100 454166013482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 454166013483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 454166013484 dimer interface [polypeptide binding]; other site 454166013485 phosphorylation site [posttranslational modification] 454166013486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 454166013487 ATP binding site [chemical binding]; other site 454166013488 Mg2+ binding site [ion binding]; other site 454166013489 G-X-G motif; other site 454166013490 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 454166013491 putative major fimbrial protein SthE; Provisional; Region: PRK15292 454166013492 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 454166013493 putative fimbrial protein SthD; Provisional; Region: PRK15293 454166013494 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 454166013495 PapC N-terminal domain; Region: PapC_N; pfam13954 454166013496 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 454166013497 PapC C-terminal domain; Region: PapC_C; pfam13953 454166013498 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 454166013499 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 454166013500 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 454166013501 putative fimbrial protein SthA; Provisional; Region: PRK15296 454166013502 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 454166013503 Helix-turn-helix domain; Region: HTH_36; pfam13730 454166013504 two-component response regulator; Provisional; Region: PRK11173 454166013505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 454166013506 active site 454166013507 phosphorylation site [posttranslational modification] 454166013508 intermolecular recognition site; other site 454166013509 dimerization interface [polypeptide binding]; other site 454166013510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 454166013511 DNA binding site [nucleotide binding] 454166013512 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 454166013513 putative RNA methyltransferase; Provisional; Region: PRK10433