-- dump date   	20140620_043545
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
321314000001	Homeodomain-like domain; Region: HTH_23; pfam13384
321314000002	Winged helix-turn helix; Region: HTH_29; pfam13551
321314000003	Homeodomain-like domain; Region: HTH_32; pfam13565
321314000004	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
321314000005	DDE superfamily endonuclease; Region: DDE_3; pfam13358
321314000006	transcriptional regulator SpvR; Provisional; Region: PRK15243
321314000007	Region: HTH motif
321314000008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314000009	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
321314000010	dimerization interface [polypeptide binding]; other site
321314000011	virulence protein SpvA; Provisional; Region: PRK15212
321314000012	virulence protein SpvB; Provisional; Region: PRK15244
321314000013	Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534
321314000014	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
321314000015	active site
321314000016	conformational flexibility of ligand binding pocket; other site
321314000017	ADP-ribosylating toxin turn-turn motif; other site
321314000018	Salmonella virulence-associated 28kDa protein; Region: VRP3; pfam03536
321314000019	virulence protein SpvD; Provisional; Region: PRK15250
321314000020	Transposase IS200 like; Region: Y1_Tnp; pfam01797
321314000021	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
321314000022	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
321314000023	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
321314000024	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314000025	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
321314000026	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314000027	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
321314000028	active site
321314000029	catalytic residues [active]
321314000030	DNA binding site [nucleotide binding]
321314000031	Int/Topo IB signature motif; other site
321314000032	plasmid maintenance protein CcdB; Provisional; Region: PRK13708
321314000033	plasmid maintenance protein CcdA; Provisional; Region: PRK13710
321314000034	Initiator Replication protein; Region: Rep_3; cl03080
321314000035	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
321314000036	Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333
321314000037	fimbrial protein PefA; Provisional; Region: PRK15214
321314000038	fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213
321314000039	PapC N-terminal domain; Region: PapC_N; pfam13954
321314000040	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314000041	fimbrial chaperone protein PefD; Provisional; Region: PRK15211
321314000042	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314000043	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314000044	replication protein; Provisional; Region: PRK13750
321314000045	RepA leader peptide Tap; Provisional; Region: PRK14745
321314000046	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
321314000047	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
321314000048	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
321314000049	putative kissing complex interaction region; other site
321314000050	putative RNA binding sites [nucleotide binding]; other site
321314000051	conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706
321314000052	DNA helicase TraI; Region: TraI; pfam07057
321314000053	TrwC relaxase; Region: TrwC; pfam08751
321314000054	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
321314000055	conjugal transfer protein TraD; Provisional; Region: PRK13700
321314000056	F sex factor protein N terminal; Region: TraD_N; pfam12615
321314000057	Bacterial conjugation protein TrwB,  ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127
321314000058	multimer interface [polypeptide binding]; other site
321314000059	Walker A motif; other site
321314000060	ATP binding site [chemical binding]; other site
321314000061	Walker B motif; other site
321314000062	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
321314000063	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
321314000064	conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735
321314000065	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
321314000066	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
321314000067	Catalytic site [active]
321314000068	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
321314000069	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
321314000070	active site
321314000071	DNA binding site [nucleotide binding]
321314000072	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
321314000073	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
321314000074	ParB-like nuclease domain; Region: ParBc; pfam02195
321314000075	ParB family; Region: ParB; pfam08775
321314000076	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
321314000077	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
321314000078	P-loop; other site
321314000079	Magnesium ion binding site [ion binding]; other site
321314000080	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
321314000081	Magnesium ion binding site [ion binding]; other site
321314000082	Uncharacterized conserved protein [Function unknown]; Region: COG5464
321314000083	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
321314000084	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
321314000085	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
321314000086	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
321314000087	catalytic site [active]
321314000088	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
321314000089	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
321314000090	active site clefts [active]
321314000091	zinc binding site [ion binding]; other site
321314000092	dimer interface [polypeptide binding]; other site
321314000093	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
321314000094	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
321314000095	catalytic residues [active]
321314000096	catalytic nucleophile [active]
321314000097	Presynaptic Site I dimer interface [polypeptide binding]; other site
321314000098	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
321314000099	Synaptic Flat tetramer interface [polypeptide binding]; other site
321314000100	Synaptic Site I dimer interface [polypeptide binding]; other site
321314000101	DNA binding site [nucleotide binding]
321314000102	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
321314000103	Integrase core domain; Region: rve; pfam00665
321314000104	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
321314000105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314000106	Walker A/P-loop; other site
321314000107	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
321314000108	catalytic triad [active]
321314000109	conserved cis-peptide bond; other site
321314000110	EamA-like transporter family; Region: EamA; pfam00892
321314000111	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
321314000112	EamA-like transporter family; Region: EamA; pfam00892
321314000113	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314000114	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314000115	putative substrate translocation pore; other site
321314000116	tetracycline repressor protein TetR; Provisional; Region: PRK13756
321314000117	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314000118	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
321314000119	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
321314000120	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
321314000121	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
321314000122	Resolvase, N terminal domain; Region: Resolvase; pfam00239
321314000123	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
321314000124	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
321314000125	DNA-binding interface [nucleotide binding]; DNA binding site
321314000126	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
321314000127	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
321314000128	DDE domain; Region: DDE_Tnp_IS240; pfam13610
321314000129	Integrase core domain; Region: rve; pfam00665
321314000130	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
321314000131	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
321314000132	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
321314000133	Presynaptic Site I dimer interface [polypeptide binding]; other site
321314000134	catalytic residues [active]
321314000135	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
321314000136	Synaptic Flat tetramer interface [polypeptide binding]; other site
321314000137	Synaptic Site I dimer interface [polypeptide binding]; other site
321314000138	DNA binding site [nucleotide binding]
321314000139	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
321314000140	DNA-binding interface [nucleotide binding]; DNA binding site
321314000141	DDE domain; Region: DDE_Tnp_IS240; pfam13610
321314000142	Integrase core domain; Region: rve; pfam00665
321314000143	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
321314000144	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
321314000145	Presynaptic Site I dimer interface [polypeptide binding]; other site
321314000146	catalytic residues [active]
321314000147	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
321314000148	Synaptic Flat tetramer interface [polypeptide binding]; other site
321314000149	Synaptic Site I dimer interface [polypeptide binding]; other site
321314000150	DNA binding site [nucleotide binding]
321314000151	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
321314000152	beta-lactamase TEM; Provisional; Region: PRK15442
321314000153	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
321314000154	putative mercuric reductase; Provisional; Region: PRK13748
321314000155	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
321314000156	metal-binding site [ion binding]
321314000157	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314000158	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314000159	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
321314000160	transcriptional regulator MerD; Provisional; Region: PRK13749
321314000161	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
321314000162	DNA binding residues [nucleotide binding]
321314000163	putative mercury resistance protein; Provisional; Region: PRK13747
321314000164	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314000165	Integrase core domain; Region: rve; pfam00665
321314000166	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
321314000167	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314000168	Integrase core domain; Region: rve; pfam00665
321314000169	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
321314000170	Phosphotransferase enzyme family; Region: APH; pfam01636
321314000171	active site
321314000172	ATP binding site [chemical binding]; other site
321314000173	antibiotic binding site [chemical binding]; other site
321314000174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
321314000175	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314000176	Integrase core domain; Region: rve; pfam00665
321314000177	integrase/recombinase; Provisional; Region: PRK15417
321314000178	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
321314000179	Int/Topo IB signature motif; other site
321314000180	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
321314000181	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
321314000182	folate binding site [chemical binding]; other site
321314000183	NADP+ binding site [chemical binding]; other site
321314000184	aminoglycoside resistance protein; Provisional; Region: PRK13746
321314000185	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
321314000186	active site
321314000187	NTP binding site [chemical binding]; other site
321314000188	metal binding triad [ion binding]; metal-binding site
321314000189	antibiotic binding site [chemical binding]; other site
321314000190	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
321314000191	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
321314000192	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
321314000193	dihydropteroate synthase; Region: DHPS; TIGR01496
321314000194	substrate binding pocket [chemical binding]; other site
321314000195	dimer interface [polypeptide binding]; other site
321314000196	inhibitor binding site; inhibition site
321314000197	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
321314000198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314000199	Coenzyme A binding pocket [chemical binding]; other site
321314000200	Bacterial TniB protein; Region: TniB; pfam05621
321314000201	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
321314000202	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314000203	Integrase core domain; Region: rve; pfam00665
321314000204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
321314000205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314000206	dimer interface [polypeptide binding]; other site
321314000207	phosphorylation site [posttranslational modification]
321314000208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314000209	ATP binding site [chemical binding]; other site
321314000210	Mg2+ binding site [ion binding]; other site
321314000211	G-X-G motif; other site
321314000212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314000213	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314000214	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
321314000215	BetR domain; Region: BetR; pfam08667
321314000216	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
321314000217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314000218	active site
321314000219	phosphorylation site [posttranslational modification]
321314000220	intermolecular recognition site; other site
321314000221	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
321314000222	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314000223	Integrase core domain; Region: rve; pfam00665
321314000224	H+ Antiporter protein; Region: 2A0121; TIGR00900
321314000225	short chain dehydrogenase; Provisional; Region: PRK08263
321314000226	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
321314000227	NADP binding site [chemical binding]; other site
321314000228	active site
321314000229	steroid binding site; other site
321314000230	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
321314000231	dihydropteroate synthase; Region: DHPS; TIGR01496
321314000232	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
321314000233	substrate binding pocket [chemical binding]; other site
321314000234	dimer interface [polypeptide binding]; other site
321314000235	inhibitor binding site; inhibition site
321314000236	Transposase, Mutator family; Region: Transposase_mut; pfam00872
321314000237	MULE transposase domain; Region: MULE; pfam10551
321314000238	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
321314000239	aminoglycoside resistance protein; Provisional; Region: PRK13746
321314000240	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
321314000241	active site
321314000242	NTP binding site [chemical binding]; other site
321314000243	metal binding triad [ion binding]; metal-binding site
321314000244	antibiotic binding site [chemical binding]; other site
321314000245	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
321314000246	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
321314000247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314000248	putative substrate translocation pore; other site
321314000249	aminoglycoside resistance protein; Provisional; Region: PRK13746
321314000250	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
321314000251	active site
321314000252	NTP binding site [chemical binding]; other site
321314000253	metal binding triad [ion binding]; metal-binding site
321314000254	antibiotic binding site [chemical binding]; other site
321314000255	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
321314000256	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
321314000257	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
321314000258	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
321314000259	TAP-like protein; Region: Abhydrolase_4; pfam08386
321314000260	integrase/recombinase; Provisional; Region: PRK15417
321314000261	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
321314000262	Int/Topo IB signature motif; other site
321314000263	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314000264	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
321314000265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
321314000266	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314000267	Integrase core domain; Region: rve; pfam00665
321314000268	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
321314000269	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
321314000270	catalytic residues [active]
321314000271	catalytic nucleophile [active]
321314000272	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
321314000273	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
321314000274	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
321314000275	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
321314000276	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
321314000277	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
321314000278	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
321314000279	Phosphotransferase enzyme family; Region: APH; pfam01636
321314000280	active site
321314000281	ATP binding site [chemical binding]; other site
321314000282	antibiotic binding site [chemical binding]; other site
321314000283	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
321314000284	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314000285	Integrase core domain; Region: rve; pfam00665
321314000286	Protein of unknown function (DUF3625); Region: DUF3625; pfam12293
321314000287	Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393
321314000288	DDE domain; Region: DDE_Tnp_IS240; pfam13610
321314000289	Integrase core domain; Region: rve; pfam00665
321314000290	AAA-like domain; Region: AAA_10; pfam12846
321314000291	indole-3-acetamide amidohydrolase; Region: PLN02722
321314000292	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
321314000293	HEAT repeats; Region: HEAT_2; pfam13646
321314000294	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
321314000295	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
321314000296	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
321314000297	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
321314000298	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
321314000299	multidrug efflux system protein; Provisional; Region: PRK11431
321314000300	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
321314000301	dimerization domain [polypeptide binding]; other site
321314000302	dimer interface [polypeptide binding]; other site
321314000303	catalytic residues [active]
321314000304	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
321314000305	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
321314000306	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
321314000307	Methyltransferase domain; Region: Methyltransf_27; pfam13708
321314000308	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
321314000309	non-specific DNA binding site [nucleotide binding]; other site
321314000310	salt bridge; other site
321314000311	sequence-specific DNA binding site [nucleotide binding]; other site
321314000312	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
321314000313	hypothetical protein; Provisional; Region: PRK09956
321314000314	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
321314000315	Protein of unknown function (DUF1472); Region: DUF1472; pfam07339
321314000316	Antirestriction protein (ArdA); Region: ArdA; pfam07275
321314000317	PsiA protein; Region: PsiA; cl11646
321314000318	plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701
321314000319	ParB-like nuclease domain; Region: ParB; smart00470
321314000320	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
321314000321	KorB domain; Region: KorB; pfam08535
321314000322	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
321314000323	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
321314000324	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
321314000325	dimer interface [polypeptide binding]; other site
321314000326	ssDNA binding site [nucleotide binding]; other site
321314000327	tetramer (dimer of dimers) interface [polypeptide binding]; other site
321314000328	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
321314000329	Antirestriction protein; Region: Antirestrict; pfam03230
321314000330	Protein of unknown function (DUF1380); Region: DUF1380; pfam07128
321314000331	putative methylase; Provisional; Region: PRK13699
321314000332	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
321314000333	Plasmid stability protein; Region: Plasmid_stab_B; pfam10784
321314000334	Protein of unknown function (DUF1281); Region: DUF1281; pfam06924
321314000335	DinI-like family; Region: DinI; pfam06183
321314000336	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
321314000337	Catalytic site [active]
321314000338	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
321314000339	active site
321314000340	catalytic residues [active]
321314000341	DNA binding site [nucleotide binding]
321314000342	Int/Topo IB signature motif; other site
321314000343	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
321314000344	active site
321314000345	catalytic residues [active]
321314000346	DNA binding site [nucleotide binding]
321314000347	Int/Topo IB signature motif; other site
321314000348	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
321314000349	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
321314000350	plasmid-partitioning protein; Provisional; Region: PRK13698
321314000351	ParB-like nuclease domain; Region: ParB; smart00470
321314000352	Initiator Replication protein; Region: Rep_3; pfam01051
321314000353	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
321314000354	transcriptional regulator MirA; Provisional; Region: PRK15043
321314000355	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
321314000356	DNA binding residues [nucleotide binding]
321314000357	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
321314000358	active site
321314000359	homotetramer interface [polypeptide binding]; other site
321314000360	Protein of unknown function (DUF523); Region: DUF523; pfam04463
321314000361	Uncharacterized conserved protein [Function unknown]; Region: COG3272
321314000362	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
321314000363	Predicted ATPase [General function prediction only]; Region: COG4637
321314000364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314000365	Walker A/P-loop; other site
321314000366	ATP binding site [chemical binding]; other site
321314000367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314000368	ABC transporter signature motif; other site
321314000369	Walker B; other site
321314000370	D-loop; other site
321314000371	H-loop/switch region; other site
321314000372	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
321314000373	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314000374	Integrase core domain; Region: rve; pfam00665
321314000375	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
321314000376	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
321314000377	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
321314000378	transposase/IS protein; Provisional; Region: PRK09183
321314000379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314000380	Walker A motif; other site
321314000381	ATP binding site [chemical binding]; other site
321314000382	Walker B motif; other site
321314000383	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
321314000384	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314000385	putative DNA binding site [nucleotide binding]; other site
321314000386	putative Zn2+ binding site [ion binding]; other site
321314000387	Integrase core domain; Region: rve; pfam00665
321314000388	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
321314000389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
321314000390	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
321314000391	Protein of unknown function (DUF524); Region: DUF524; pfam04411
321314000392	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
321314000393	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
321314000394	HTH-like domain; Region: HTH_21; pfam13276
321314000395	Integrase core domain; Region: rve; pfam00665
321314000396	Integrase core domain; Region: rve_3; pfam13683
321314000397	Transposase; Region: HTH_Tnp_1; pfam01527
321314000398	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
321314000399	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
321314000400	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
321314000401	active site
321314000402	DNA binding site [nucleotide binding]
321314000403	Int/Topo IB signature motif; other site
321314000404	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
321314000405	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
321314000406	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
321314000407	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
321314000408	putative catalytic residues [active]
321314000409	putative nucleotide binding site [chemical binding]; other site
321314000410	putative aspartate binding site [chemical binding]; other site
321314000411	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
321314000412	dimer interface [polypeptide binding]; other site
321314000413	putative threonine allosteric regulatory site; other site
321314000414	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
321314000415	putative threonine allosteric regulatory site; other site
321314000416	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
321314000417	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
321314000418	homoserine kinase; Provisional; Region: PRK01212
321314000419	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
321314000420	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
321314000421	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
321314000422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314000423	catalytic residue [active]
321314000424	hypothetical protein; Validated; Region: PRK02101
321314000425	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
321314000426	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
321314000427	transaldolase-like protein; Provisional; Region: PTZ00411
321314000428	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
321314000429	active site
321314000430	dimer interface [polypeptide binding]; other site
321314000431	catalytic residue [active]
321314000432	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
321314000433	MPT binding site; other site
321314000434	trimer interface [polypeptide binding]; other site
321314000435	hypothetical protein; Provisional; Region: PRK10659
321314000436	hypothetical protein; Provisional; Region: PRK10236
321314000437	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
321314000438	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
321314000439	hypothetical protein; Provisional; Region: PRK10154
321314000440	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
321314000441	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
321314000442	nucleotide binding site [chemical binding]; other site
321314000443	chaperone protein DnaJ; Provisional; Region: PRK10767
321314000444	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
321314000445	HSP70 interaction site [polypeptide binding]; other site
321314000446	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
321314000447	substrate binding site [polypeptide binding]; other site
321314000448	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
321314000449	Zn binding sites [ion binding]; other site
321314000450	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
321314000451	dimer interface [polypeptide binding]; other site
321314000452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314000453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314000454	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
321314000455	substrate binding pocket [chemical binding]; other site
321314000456	dimerization interface [polypeptide binding]; other site
321314000457	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
321314000458	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
321314000459	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
321314000460	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
321314000461	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
321314000462	Helix-turn-helix domain; Region: HTH_36; pfam13730
321314000463	fimbrial protein BcfA; Provisional; Region: PRK15187
321314000464	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
321314000465	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314000466	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314000467	fimbrial protein BcfD; Provisional; Region: PRK15189
321314000468	fimbrial protein BcfE; Provisional; Region: PRK15190
321314000469	fimbrial protein BcfF; Provisional; Region: PRK15191
321314000470	fimbrial chaperone BcfG; Provisional; Region: PRK15192
321314000471	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314000472	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314000473	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
321314000474	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
321314000475	catalytic residues [active]
321314000476	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
321314000477	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
321314000478	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
321314000479	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314000480	FeS/SAM binding site; other site
321314000481	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
321314000482	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
321314000483	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
321314000484	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
321314000485	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314000486	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
321314000487	putative dimerization interface [polypeptide binding]; other site
321314000488	putative alpha-glucosidase; Provisional; Region: PRK10658
321314000489	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
321314000490	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
321314000491	putative active site [active]
321314000492	putative catalytic site [active]
321314000493	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
321314000494	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
321314000495	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
321314000496	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
321314000497	active site
321314000498	Riboflavin kinase; Region: Flavokinase; smart00904
321314000499	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
321314000500	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
321314000501	active site
321314000502	HIGH motif; other site
321314000503	nucleotide binding site [chemical binding]; other site
321314000504	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
321314000505	active site
321314000506	KMSKS motif; other site
321314000507	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
321314000508	tRNA binding surface [nucleotide binding]; other site
321314000509	anticodon binding site; other site
321314000510	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
321314000511	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
321314000512	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
321314000513	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
321314000514	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
321314000515	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
321314000516	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
321314000517	active site
321314000518	tetramer interface [polypeptide binding]; other site
321314000519	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
321314000520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314000521	active site
321314000522	phosphorylation site [posttranslational modification]
321314000523	intermolecular recognition site; other site
321314000524	dimerization interface [polypeptide binding]; other site
321314000525	Transcriptional regulator; Region: CitT; pfam12431
321314000526	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
321314000527	PAS domain; Region: PAS; smart00091
321314000528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314000529	ATP binding site [chemical binding]; other site
321314000530	Mg2+ binding site [ion binding]; other site
321314000531	G-X-G motif; other site
321314000532	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
321314000533	oxaloacetate decarboxylase; Provisional; Region: PRK14040
321314000534	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
321314000535	active site
321314000536	catalytic residues [active]
321314000537	metal binding site [ion binding]; metal-binding site
321314000538	homodimer binding site [polypeptide binding]; other site
321314000539	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
321314000540	carboxyltransferase (CT) interaction site; other site
321314000541	biotinylation site [posttranslational modification]; other site
321314000542	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
321314000543	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
321314000544	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
321314000545	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
321314000546	putative active site [active]
321314000547	(T/H)XGH motif; other site
321314000548	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
321314000549	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
321314000550	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
321314000551	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
321314000552	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
321314000553	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
321314000554	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
321314000555	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
321314000556	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
321314000557	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
321314000558	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
321314000559	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
321314000560	catalytic site [active]
321314000561	subunit interface [polypeptide binding]; other site
321314000562	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
321314000563	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
321314000564	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
321314000565	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
321314000566	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
321314000567	ATP-grasp domain; Region: ATP-grasp_4; cl17255
321314000568	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
321314000569	IMP binding site; other site
321314000570	dimer interface [polypeptide binding]; other site
321314000571	interdomain contacts; other site
321314000572	partial ornithine binding site; other site
321314000573	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
321314000574	carnitine operon protein CaiE; Provisional; Region: PRK13627
321314000575	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
321314000576	putative trimer interface [polypeptide binding]; other site
321314000577	putative metal binding site [ion binding]; other site
321314000578	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
321314000579	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
321314000580	substrate binding site [chemical binding]; other site
321314000581	oxyanion hole (OAH) forming residues; other site
321314000582	trimer interface [polypeptide binding]; other site
321314000583	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
321314000584	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
321314000585	acyl-activating enzyme (AAE) consensus motif; other site
321314000586	putative AMP binding site [chemical binding]; other site
321314000587	putative active site [active]
321314000588	putative CoA binding site [chemical binding]; other site
321314000589	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
321314000590	CoA-transferase family III; Region: CoA_transf_3; pfam02515
321314000591	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
321314000592	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
321314000593	active site
321314000594	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
321314000595	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
321314000596	Ligand binding site [chemical binding]; other site
321314000597	Electron transfer flavoprotein domain; Region: ETF; pfam01012
321314000598	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
321314000599	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
321314000600	Ligand binding site [chemical binding]; other site
321314000601	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
321314000602	putative oxidoreductase FixC; Provisional; Region: PRK10157
321314000603	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
321314000604	ferredoxin-like protein FixX; Provisional; Region: PRK15449
321314000605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314000606	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
321314000607	putative substrate translocation pore; other site
321314000608	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
321314000609	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314000610	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
321314000611	Sulfatase; Region: Sulfatase; cl17466
321314000612	Sulfatase; Region: Sulfatase; cl17466
321314000613	Sulfatase; Region: Sulfatase; cl17466
321314000614	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
321314000615	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
321314000616	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
321314000617	TrkA-N domain; Region: TrkA_N; pfam02254
321314000618	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
321314000619	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
321314000620	folate binding site [chemical binding]; other site
321314000621	NADP+ binding site [chemical binding]; other site
321314000622	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
321314000623	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
321314000624	active site
321314000625	metal binding site [ion binding]; metal-binding site
321314000626	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
321314000627	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
321314000628	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
321314000629	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
321314000630	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
321314000631	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
321314000632	SurA N-terminal domain; Region: SurA_N; pfam09312
321314000633	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
321314000634	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
321314000635	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
321314000636	OstA-like protein; Region: OstA; pfam03968
321314000637	Organic solvent tolerance protein; Region: OstA_C; pfam04453
321314000638	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
321314000639	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
321314000640	putative metal binding site [ion binding]; other site
321314000641	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
321314000642	HSP70 interaction site [polypeptide binding]; other site
321314000643	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
321314000644	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
321314000645	active site
321314000646	ATP-dependent helicase HepA; Validated; Region: PRK04914
321314000647	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314000648	ATP binding site [chemical binding]; other site
321314000649	putative Mg++ binding site [ion binding]; other site
321314000650	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314000651	nucleotide binding region [chemical binding]; other site
321314000652	ATP-binding site [chemical binding]; other site
321314000653	DNA polymerase II; Reviewed; Region: PRK05762
321314000654	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
321314000655	active site
321314000656	catalytic site [active]
321314000657	substrate binding site [chemical binding]; other site
321314000658	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
321314000659	active site
321314000660	metal-binding site
321314000661	Uncharacterized conserved protein [Function unknown]; Region: COG1434
321314000662	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
321314000663	putative active site [active]
321314000664	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
321314000665	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
321314000666	intersubunit interface [polypeptide binding]; other site
321314000667	active site
321314000668	Zn2+ binding site [ion binding]; other site
321314000669	L-arabinose isomerase; Provisional; Region: PRK02929
321314000670	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
321314000671	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
321314000672	trimer interface [polypeptide binding]; other site
321314000673	putative substrate binding site [chemical binding]; other site
321314000674	putative metal binding site [ion binding]; other site
321314000675	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
321314000676	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
321314000677	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314000678	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314000679	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
321314000680	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
321314000681	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
321314000682	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
321314000683	Walker A/P-loop; other site
321314000684	ATP binding site [chemical binding]; other site
321314000685	Q-loop/lid; other site
321314000686	ABC transporter signature motif; other site
321314000687	Walker B; other site
321314000688	D-loop; other site
321314000689	H-loop/switch region; other site
321314000690	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
321314000691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314000692	dimer interface [polypeptide binding]; other site
321314000693	conserved gate region; other site
321314000694	putative PBP binding loops; other site
321314000695	ABC-ATPase subunit interface; other site
321314000696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314000697	dimer interface [polypeptide binding]; other site
321314000698	conserved gate region; other site
321314000699	putative PBP binding loops; other site
321314000700	ABC-ATPase subunit interface; other site
321314000701	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
321314000702	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
321314000703	transcriptional regulator SgrR; Provisional; Region: PRK13626
321314000704	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
321314000705	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
321314000706	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
321314000707	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
321314000708	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
321314000709	substrate binding site [chemical binding]; other site
321314000710	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
321314000711	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
321314000712	substrate binding site [chemical binding]; other site
321314000713	ligand binding site [chemical binding]; other site
321314000714	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
321314000715	tartrate dehydrogenase; Region: TTC; TIGR02089
321314000716	2-isopropylmalate synthase; Validated; Region: PRK00915
321314000717	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
321314000718	active site
321314000719	catalytic residues [active]
321314000720	metal binding site [ion binding]; metal-binding site
321314000721	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
321314000722	leu operon leader peptide; Provisional; Region: PRK14744
321314000723	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
321314000724	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
321314000725	PYR/PP interface [polypeptide binding]; other site
321314000726	dimer interface [polypeptide binding]; other site
321314000727	TPP binding site [chemical binding]; other site
321314000728	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
321314000729	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
321314000730	TPP-binding site [chemical binding]; other site
321314000731	dimer interface [polypeptide binding]; other site
321314000732	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
321314000733	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
321314000734	putative valine binding site [chemical binding]; other site
321314000735	dimer interface [polypeptide binding]; other site
321314000736	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
321314000737	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
321314000738	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314000739	DNA binding site [nucleotide binding]
321314000740	domain linker motif; other site
321314000741	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
321314000742	dimerization interface [polypeptide binding]; other site
321314000743	ligand binding site [chemical binding]; other site
321314000744	mraZ protein; Region: TIGR00242
321314000745	MraZ protein; Region: MraZ; pfam02381
321314000746	MraZ protein; Region: MraZ; pfam02381
321314000747	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
321314000748	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
321314000749	cell division protein FtsL; Provisional; Region: PRK10772
321314000750	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
321314000751	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
321314000752	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
321314000753	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
321314000754	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
321314000755	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
321314000756	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
321314000757	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
321314000758	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
321314000759	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
321314000760	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
321314000761	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
321314000762	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
321314000763	Mg++ binding site [ion binding]; other site
321314000764	putative catalytic motif [active]
321314000765	putative substrate binding site [chemical binding]; other site
321314000766	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
321314000767	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
321314000768	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
321314000769	cell division protein FtsW; Provisional; Region: PRK10774
321314000770	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
321314000771	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
321314000772	active site
321314000773	homodimer interface [polypeptide binding]; other site
321314000774	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
321314000775	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
321314000776	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
321314000777	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
321314000778	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
321314000779	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
321314000780	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
321314000781	cell division protein FtsQ; Provisional; Region: PRK10775
321314000782	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
321314000783	Cell division protein FtsQ; Region: FtsQ; pfam03799
321314000784	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
321314000785	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314000786	Cell division protein FtsA; Region: FtsA; pfam14450
321314000787	cell division protein FtsZ; Validated; Region: PRK09330
321314000788	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
321314000789	nucleotide binding site [chemical binding]; other site
321314000790	SulA interaction site; other site
321314000791	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
321314000792	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
321314000793	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
321314000794	SecA regulator SecM; Provisional; Region: PRK02943
321314000795	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
321314000796	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
321314000797	SEC-C motif; Region: SEC-C; pfam02810
321314000798	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
321314000799	active site
321314000800	8-oxo-dGMP binding site [chemical binding]; other site
321314000801	nudix motif; other site
321314000802	metal binding site [ion binding]; metal-binding site
321314000803	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314000804	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314000805	active site
321314000806	catalytic tetrad [active]
321314000807	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314000808	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314000809	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
321314000810	putative effector binding pocket; other site
321314000811	putative dimerization interface [polypeptide binding]; other site
321314000812	DNA gyrase inhibitor; Reviewed; Region: PRK00418
321314000813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
321314000814	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
321314000815	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
321314000816	CoA-binding site [chemical binding]; other site
321314000817	ATP-binding [chemical binding]; other site
321314000818	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
321314000819	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
321314000820	active site
321314000821	type IV pilin biogenesis protein; Provisional; Region: PRK10573
321314000822	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
321314000823	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
321314000824	hypothetical protein; Provisional; Region: PRK10436
321314000825	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
321314000826	Walker A motif; other site
321314000827	ATP binding site [chemical binding]; other site
321314000828	Walker B motif; other site
321314000829	putative major pilin subunit; Provisional; Region: PRK10574
321314000830	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
321314000831	Pilin (bacterial filament); Region: Pilin; pfam00114
321314000832	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
321314000833	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
321314000834	dimerization interface [polypeptide binding]; other site
321314000835	active site
321314000836	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
321314000837	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
321314000838	amidase catalytic site [active]
321314000839	Zn binding residues [ion binding]; other site
321314000840	substrate binding site [chemical binding]; other site
321314000841	regulatory protein AmpE; Provisional; Region: PRK10987
321314000842	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
321314000843	active site
321314000844	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
321314000845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314000846	putative substrate translocation pore; other site
321314000847	aromatic amino acid transporter; Provisional; Region: PRK10238
321314000848	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
321314000849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314000850	DNA-binding site [nucleotide binding]; DNA binding site
321314000851	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
321314000852	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
321314000853	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
321314000854	dimer interface [polypeptide binding]; other site
321314000855	TPP-binding site [chemical binding]; other site
321314000856	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
321314000857	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
321314000858	E3 interaction surface; other site
321314000859	lipoyl attachment site [posttranslational modification]; other site
321314000860	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
321314000861	E3 interaction surface; other site
321314000862	lipoyl attachment site [posttranslational modification]; other site
321314000863	e3 binding domain; Region: E3_binding; pfam02817
321314000864	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
321314000865	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
321314000866	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
321314000867	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314000868	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
321314000869	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
321314000870	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
321314000871	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
321314000872	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
321314000873	substrate binding site [chemical binding]; other site
321314000874	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
321314000875	substrate binding site [chemical binding]; other site
321314000876	ligand binding site [chemical binding]; other site
321314000877	putative inner membrane protein; Provisional; Region: PRK09823
321314000878	Low molecular weight phosphatase family; Region: LMWPc; cl00105
321314000879	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
321314000880	active site
321314000881	hypothetical protein; Provisional; Region: PRK05248
321314000882	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
321314000883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
321314000884	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
321314000885	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
321314000886	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314000887	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
321314000888	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314000889	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
321314000890	spermidine synthase; Provisional; Region: PRK00811
321314000891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314000892	S-adenosylmethionine binding site [chemical binding]; other site
321314000893	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
321314000894	multicopper oxidase; Provisional; Region: PRK10965
321314000895	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
321314000896	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
321314000897	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
321314000898	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
321314000899	Trp docking motif [polypeptide binding]; other site
321314000900	putative active site [active]
321314000901	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
321314000902	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314000903	active site
321314000904	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
321314000905	active site clefts [active]
321314000906	zinc binding site [ion binding]; other site
321314000907	dimer interface [polypeptide binding]; other site
321314000908	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
321314000909	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
321314000910	Walker A/P-loop; other site
321314000911	ATP binding site [chemical binding]; other site
321314000912	Q-loop/lid; other site
321314000913	ABC transporter signature motif; other site
321314000914	Walker B; other site
321314000915	D-loop; other site
321314000916	H-loop/switch region; other site
321314000917	inner membrane transport permease; Provisional; Region: PRK15066
321314000918	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
321314000919	putative fimbrial protein StiH; Provisional; Region: PRK15297
321314000920	fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298
321314000921	PapC N-terminal domain; Region: PapC_N; pfam13954
321314000922	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314000923	PapC C-terminal domain; Region: PapC_C; pfam13953
321314000924	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
321314000925	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314000926	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314000927	fimbrial protein StiA; Provisional; Region: PRK15300
321314000928	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
321314000929	active pocket/dimerization site; other site
321314000930	active site
321314000931	phosphorylation site [posttranslational modification]
321314000932	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
321314000933	putative active site [active]
321314000934	putative metal binding site [ion binding]; other site
321314000935	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
321314000936	tetramerization interface [polypeptide binding]; other site
321314000937	active site
321314000938	Pantoate-beta-alanine ligase; Region: PanC; cd00560
321314000939	pantoate--beta-alanine ligase; Region: panC; TIGR00018
321314000940	active site
321314000941	ATP-binding site [chemical binding]; other site
321314000942	pantoate-binding site; other site
321314000943	HXXH motif; other site
321314000944	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
321314000945	oligomerization interface [polypeptide binding]; other site
321314000946	active site
321314000947	metal binding site [ion binding]; metal-binding site
321314000948	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
321314000949	catalytic center binding site [active]
321314000950	ATP binding site [chemical binding]; other site
321314000951	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
321314000952	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
321314000953	active site
321314000954	NTP binding site [chemical binding]; other site
321314000955	metal binding triad [ion binding]; metal-binding site
321314000956	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
321314000957	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
321314000958	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
321314000959	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
321314000960	active site
321314000961	nucleotide binding site [chemical binding]; other site
321314000962	HIGH motif; other site
321314000963	KMSKS motif; other site
321314000964	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
321314000965	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
321314000966	2'-5' RNA ligase; Provisional; Region: PRK15124
321314000967	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
321314000968	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
321314000969	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
321314000970	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314000971	ATP binding site [chemical binding]; other site
321314000972	putative Mg++ binding site [ion binding]; other site
321314000973	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314000974	nucleotide binding region [chemical binding]; other site
321314000975	ATP-binding site [chemical binding]; other site
321314000976	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
321314000977	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
321314000978	Transglycosylase; Region: Transgly; pfam00912
321314000979	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
321314000980	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
321314000981	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314000982	N-terminal plug; other site
321314000983	ligand-binding site [chemical binding]; other site
321314000984	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
321314000985	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
321314000986	Walker A/P-loop; other site
321314000987	ATP binding site [chemical binding]; other site
321314000988	Q-loop/lid; other site
321314000989	ABC transporter signature motif; other site
321314000990	Walker B; other site
321314000991	D-loop; other site
321314000992	H-loop/switch region; other site
321314000993	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
321314000994	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
321314000995	siderophore binding site; other site
321314000996	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
321314000997	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314000998	ABC-ATPase subunit  interface; other site
321314000999	dimer interface [polypeptide binding]; other site
321314001000	putative PBP binding regions; other site
321314001001	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314001002	ABC-ATPase subunit  interface; other site
321314001003	dimer interface [polypeptide binding]; other site
321314001004	putative PBP binding regions; other site
321314001005	putative fimbrial subunit StfA; Provisional; Region: PRK15283
321314001006	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
321314001007	PapC N-terminal domain; Region: PapC_N; pfam13954
321314001008	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314001009	PapC C-terminal domain; Region: PapC_C; pfam13953
321314001010	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
321314001011	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314001012	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314001013	putative minor fimbrial subunit StfE; Provisional; Region: PRK15286
321314001014	putative minor fimbrial subunit StfF; Provisional; Region: PRK15287
321314001015	putative minor fimbrial subunit StfG; Provisional; Region: PRK15288
321314001016	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
321314001017	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
321314001018	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
321314001019	inhibitor-cofactor binding pocket; inhibition site
321314001020	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314001021	catalytic residue [active]
321314001022	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
321314001023	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
321314001024	Cl- selectivity filter; other site
321314001025	Cl- binding residues [ion binding]; other site
321314001026	pore gating glutamate residue; other site
321314001027	dimer interface [polypeptide binding]; other site
321314001028	H+/Cl- coupling transport residue; other site
321314001029	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
321314001030	hypothetical protein; Provisional; Region: PRK10578
321314001031	UPF0126 domain; Region: UPF0126; pfam03458
321314001032	UPF0126 domain; Region: UPF0126; pfam03458
321314001033	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
321314001034	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
321314001035	cobalamin binding residues [chemical binding]; other site
321314001036	putative BtuC binding residues; other site
321314001037	dimer interface [polypeptide binding]; other site
321314001038	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
321314001039	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
321314001040	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
321314001041	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
321314001042	Zn2+ binding site [ion binding]; other site
321314001043	Mg2+ binding site [ion binding]; other site
321314001044	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
321314001045	serine endoprotease; Provisional; Region: PRK10942
321314001046	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
321314001047	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
321314001048	protein binding site [polypeptide binding]; other site
321314001049	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
321314001050	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
321314001051	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
321314001052	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
321314001053	hypothetical protein; Provisional; Region: PRK13677
321314001054	shikimate transporter; Provisional; Region: PRK09952
321314001055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001056	putative substrate translocation pore; other site
321314001057	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
321314001058	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
321314001059	trimer interface [polypeptide binding]; other site
321314001060	active site
321314001061	substrate binding site [chemical binding]; other site
321314001062	CoA binding site [chemical binding]; other site
321314001063	PII uridylyl-transferase; Provisional; Region: PRK05007
321314001064	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
321314001065	metal binding triad; other site
321314001066	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
321314001067	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
321314001068	Zn2+ binding site [ion binding]; other site
321314001069	Mg2+ binding site [ion binding]; other site
321314001070	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
321314001071	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
321314001072	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
321314001073	active site
321314001074	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
321314001075	rRNA interaction site [nucleotide binding]; other site
321314001076	S8 interaction site; other site
321314001077	putative laminin-1 binding site; other site
321314001078	elongation factor Ts; Provisional; Region: tsf; PRK09377
321314001079	UBA/TS-N domain; Region: UBA; pfam00627
321314001080	Elongation factor TS; Region: EF_TS; pfam00889
321314001081	Elongation factor TS; Region: EF_TS; pfam00889
321314001082	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
321314001083	putative nucleotide binding site [chemical binding]; other site
321314001084	uridine monophosphate binding site [chemical binding]; other site
321314001085	homohexameric interface [polypeptide binding]; other site
321314001086	ribosome recycling factor; Reviewed; Region: frr; PRK00083
321314001087	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
321314001088	hinge region; other site
321314001089	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
321314001090	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
321314001091	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
321314001092	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
321314001093	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
321314001094	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
321314001095	catalytic residue [active]
321314001096	putative FPP diphosphate  binding site; other site
321314001097	putative FPP binding hydrophobic cleft; other site
321314001098	dimer interface [polypeptide binding]; other site
321314001099	putative IPP diphosphate binding site; other site
321314001100	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
321314001101	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
321314001102	zinc metallopeptidase RseP; Provisional; Region: PRK10779
321314001103	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
321314001104	active site
321314001105	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
321314001106	protein binding site [polypeptide binding]; other site
321314001107	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
321314001108	protein binding site [polypeptide binding]; other site
321314001109	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
321314001110	putative substrate binding region [chemical binding]; other site
321314001111	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
321314001112	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
321314001113	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
321314001114	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
321314001115	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
321314001116	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
321314001117	Surface antigen; Region: Bac_surface_Ag; pfam01103
321314001118	periplasmic chaperone; Provisional; Region: PRK10780
321314001119	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
321314001120	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
321314001121	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
321314001122	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
321314001123	trimer interface [polypeptide binding]; other site
321314001124	active site
321314001125	UDP-GlcNAc binding site [chemical binding]; other site
321314001126	lipid binding site [chemical binding]; lipid-binding site
321314001127	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
321314001128	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
321314001129	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
321314001130	active site
321314001131	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
321314001132	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
321314001133	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
321314001134	RNA/DNA hybrid binding site [nucleotide binding]; other site
321314001135	active site
321314001136	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
321314001137	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
321314001138	putative active site [active]
321314001139	putative PHP Thumb interface [polypeptide binding]; other site
321314001140	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
321314001141	generic binding surface II; other site
321314001142	generic binding surface I; other site
321314001143	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
321314001144	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
321314001145	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
321314001146	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
321314001147	putative sugar binding site [chemical binding]; other site
321314001148	catalytic residues [active]
321314001149	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
321314001150	lysine decarboxylase LdcC; Provisional; Region: PRK15399
321314001151	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
321314001152	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
321314001153	homodimer interface [polypeptide binding]; other site
321314001154	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314001155	catalytic residue [active]
321314001156	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
321314001157	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
321314001158	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
321314001159	putative metal binding site [ion binding]; other site
321314001160	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
321314001161	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
321314001162	Ligand Binding Site [chemical binding]; other site
321314001163	TilS substrate binding domain; Region: TilS; pfam09179
321314001164	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
321314001165	Rho-binding antiterminator; Provisional; Region: PRK11625
321314001166	hypothetical protein; Provisional; Region: PRK04964
321314001167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
321314001168	hypothetical protein; Provisional; Region: PRK09256
321314001169	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
321314001170	prolyl-tRNA synthetase; Provisional; Region: PRK09194
321314001171	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
321314001172	dimer interface [polypeptide binding]; other site
321314001173	motif 1; other site
321314001174	active site
321314001175	motif 2; other site
321314001176	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
321314001177	putative deacylase active site [active]
321314001178	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
321314001179	active site
321314001180	motif 3; other site
321314001181	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
321314001182	anticodon binding site; other site
321314001183	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
321314001184	homodimer interaction site [polypeptide binding]; other site
321314001185	cofactor binding site; other site
321314001186	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
321314001187	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
321314001188	lipoprotein, YaeC family; Region: TIGR00363
321314001189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314001190	dimer interface [polypeptide binding]; other site
321314001191	conserved gate region; other site
321314001192	ABC-ATPase subunit interface; other site
321314001193	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
321314001194	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
321314001195	Walker A/P-loop; other site
321314001196	ATP binding site [chemical binding]; other site
321314001197	Q-loop/lid; other site
321314001198	ABC transporter signature motif; other site
321314001199	Walker B; other site
321314001200	D-loop; other site
321314001201	H-loop/switch region; other site
321314001202	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
321314001203	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
321314001204	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314001205	active site
321314001206	motif I; other site
321314001207	motif II; other site
321314001208	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314001209	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314001210	active site
321314001211	catalytic tetrad [active]
321314001212	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314001213	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314001214	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
321314001215	putative effector binding pocket; other site
321314001216	dimerization interface [polypeptide binding]; other site
321314001217	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
321314001218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001219	putative substrate translocation pore; other site
321314001220	hypothetical protein; Provisional; Region: PRK05421
321314001221	putative catalytic site [active]
321314001222	putative metal binding site [ion binding]; other site
321314001223	putative phosphate binding site [ion binding]; other site
321314001224	putative catalytic site [active]
321314001225	putative phosphate binding site [ion binding]; other site
321314001226	putative metal binding site [ion binding]; other site
321314001227	Methyltransferase domain; Region: Methyltransf_23; pfam13489
321314001228	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314001229	S-adenosylmethionine binding site [chemical binding]; other site
321314001230	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
321314001231	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314001232	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314001233	catalytic residue [active]
321314001234	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314001235	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314001236	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
321314001237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314001238	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
321314001239	RNA/DNA hybrid binding site [nucleotide binding]; other site
321314001240	active site
321314001241	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
321314001242	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
321314001243	active site
321314001244	catalytic site [active]
321314001245	substrate binding site [chemical binding]; other site
321314001246	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
321314001247	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
321314001248	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
321314001249	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
321314001250	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
321314001251	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
321314001252	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
321314001253	ImpE protein; Region: ImpE; pfam07024
321314001254	similar to hypothetical protein
321314001255	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
321314001256	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
321314001257	Protein of unknown function (DUF877); Region: DUF877; pfam05943
321314001258	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
321314001259	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
321314001260	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
321314001261	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
321314001262	hypothetical protein; Provisional; Region: PRK08126
321314001263	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
321314001264	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
321314001265	ligand binding site [chemical binding]; other site
321314001266	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
321314001267	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
321314001268	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
321314001269	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
321314001270	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
321314001271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
321314001272	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
321314001273	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
321314001274	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
321314001275	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
321314001276	PAAR motif; Region: PAAR_motif; pfam05488
321314001277	RHS Repeat; Region: RHS_repeat; cl11982
321314001278	RHS Repeat; Region: RHS_repeat; cl11982
321314001279	RHS Repeat; Region: RHS_repeat; cl11982
321314001280	RHS Repeat; Region: RHS_repeat; pfam05593
321314001281	RHS Repeat; Region: RHS_repeat; pfam05593
321314001282	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
321314001283	RHS Repeat; Region: RHS_repeat; pfam05593
321314001284	RHS Repeat; Region: RHS_repeat; pfam05593
321314001285	RHS Repeat; Region: RHS_repeat; pfam05593
321314001286	RHS Repeat; Region: RHS_repeat; pfam05593
321314001287	RHS Repeat; Region: RHS_repeat; pfam05593
321314001288	RHS Repeat; Region: RHS_repeat; cl11982
321314001289	RHS protein; Region: RHS; pfam03527
321314001290	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
321314001291	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
321314001292	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
321314001293	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
321314001294	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
321314001295	similar to IS200
321314001296	similar to IS200
321314001297	similar to IS200
321314001298	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
321314001299	Integrase core domain; Region: rve_3; pfam13683
321314001300	Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221
321314001301	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
321314001302	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314001303	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314001304	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
321314001305	PapC N-terminal domain; Region: PapC_N; pfam13954
321314001306	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314001307	PapC C-terminal domain; Region: PapC_C; pfam13953
321314001308	putative pilin structural protein SafD; Provisional; Region: PRK15222
321314001309	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
321314001310	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
321314001311	putative active site [active]
321314001312	putative metal binding site [ion binding]; other site
321314001313	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314001314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314001315	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314001316	dimerization interface [polypeptide binding]; other site
321314001317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
321314001318	putative fimbrial protein TcfA; Provisional; Region: PRK15308
321314001319	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
321314001320	putative fimbrial subunit TcfB; Provisional; Region: PRK15309
321314001321	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
321314001322	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
321314001323	AsnC family; Region: AsnC_trans_reg; pfam01037
321314001324	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
321314001325	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
321314001326	dimer interface [polypeptide binding]; other site
321314001327	C-N hydrolase family amidase; Provisional; Region: PRK10438
321314001328	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
321314001329	putative active site [active]
321314001330	catalytic triad [active]
321314001331	dimer interface [polypeptide binding]; other site
321314001332	multimer interface [polypeptide binding]; other site
321314001333	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
321314001334	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
321314001335	active site
321314001336	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
321314001337	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
321314001338	dimer interface [polypeptide binding]; other site
321314001339	active site
321314001340	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
321314001341	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
321314001342	putative active site [active]
321314001343	putative dimer interface [polypeptide binding]; other site
321314001344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
321314001345	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
321314001346	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
321314001347	active site
321314001348	DNA polymerase IV; Validated; Region: PRK02406
321314001349	DNA binding site [nucleotide binding]
321314001350	hypothetical protein; Reviewed; Region: PRK09588
321314001351	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
321314001352	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
321314001353	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
321314001354	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
321314001355	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
321314001356	metal binding site [ion binding]; metal-binding site
321314001357	dimer interface [polypeptide binding]; other site
321314001358	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314001359	active site
321314001360	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
321314001361	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
321314001362	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314001363	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
321314001364	trimer interface [polypeptide binding]; other site
321314001365	eyelet of channel; other site
321314001366	gamma-glutamyl kinase; Provisional; Region: PRK05429
321314001367	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
321314001368	nucleotide binding site [chemical binding]; other site
321314001369	homotetrameric interface [polypeptide binding]; other site
321314001370	putative phosphate binding site [ion binding]; other site
321314001371	putative allosteric binding site; other site
321314001372	PUA domain; Region: PUA; pfam01472
321314001373	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
321314001374	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
321314001375	putative catalytic cysteine [active]
321314001376	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
321314001377	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
321314001378	Int/Topo IB signature motif; other site
321314001379	Protein of unknown function (DUF551); Region: DUF551; pfam04448
321314001380	Protein of unknown function DUF262; Region: DUF262; pfam03235
321314001381	Uncharacterized conserved protein [Function unknown]; Region: COG1479
321314001382	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
321314001383	active site
321314001384	catalytic site [active]
321314001385	substrate binding site [chemical binding]; other site
321314001386	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
321314001387	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
321314001388	dimer interface [polypeptide binding]; other site
321314001389	ssDNA binding site [nucleotide binding]; other site
321314001390	tetramer (dimer of dimers) interface [polypeptide binding]; other site
321314001391	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
321314001392	Lambda Phage CIII; Region: Lambda_CIII; pfam02061
321314001393	hypothetical protein; Provisional; Region: PRK09946
321314001394	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314001395	non-specific DNA binding site [nucleotide binding]; other site
321314001396	salt bridge; other site
321314001397	sequence-specific DNA binding site [nucleotide binding]; other site
321314001398	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
321314001399	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
321314001400	active site
321314001401	metal binding site [ion binding]; metal-binding site
321314001402	interdomain interaction site; other site
321314001403	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
321314001404	Walker A motif; other site
321314001405	ATP binding site [chemical binding]; other site
321314001406	AAA domain; Region: AAA_25; pfam13481
321314001407	Walker B motif; other site
321314001408	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
321314001409	Active Sites [active]
321314001410	endodeoxyribonuclease RUS; Reviewed; Region: PRK09786
321314001411	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
321314001412	phage holin, lambda family; Region: holin_lambda; TIGR01594
321314001413	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
321314001414	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314001415	catalytic residue [active]
321314001416	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
321314001417	T5orf172 domain; Region: T5orf172; pfam10544
321314001418	Protein of unknown function (DUF2560); Region: DUF2560; pfam10834
321314001419	Terminase-like family; Region: Terminase_6; pfam03237
321314001420	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
321314001421	Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306
321314001422	coat protein; Region: PHA01511
321314001423	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
321314001424	P22 tail accessory factor; Region: P22_Tail-4; pfam11650
321314001425	Phage stabilisation protein; Region: Phage_stabilise; pfam11134
321314001426	Protein of unknown function (DUF2824); Region: DUF2824; pfam11039
321314001427	Head binding; Region: Head_binding; pfam09008
321314001428	Right handed beta helix region; Region: Beta_helix; pfam13229
321314001429	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
321314001430	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
321314001431	Ligand binding site; other site
321314001432	Putative Catalytic site; other site
321314001433	DXD motif; other site
321314001434	Predicted membrane protein [Function unknown]; Region: COG2246
321314001435	GtrA-like protein; Region: GtrA; pfam04138
321314001436	similar to IS1230
321314001437	HTH-like domain; Region: HTH_21; pfam13276
321314001438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
321314001439	Integrase core domain; Region: rve; pfam00665
321314001440	Integrase core domain; Region: rve_2; pfam13333
321314001441	similar to IS3
321314001442	similar to IS1230
321314001443	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
321314001444	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
321314001445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001446	putative substrate translocation pore; other site
321314001447	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
321314001448	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
321314001449	substrate binding site [chemical binding]; other site
321314001450	ligand binding site [chemical binding]; other site
321314001451	3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066
321314001452	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
321314001453	hypothetical protein; Provisional; Region: PRK14812
321314001454	substrate binding site [chemical binding]; other site
321314001455	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
321314001456	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
321314001457	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
321314001458	transcriptional activator TtdR; Provisional; Region: PRK09801
321314001459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314001460	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
321314001461	putative effector binding pocket; other site
321314001462	putative dimerization interface [polypeptide binding]; other site
321314001463	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
321314001464	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
321314001465	PapC N-terminal domain; Region: PapC_N; pfam13954
321314001466	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314001467	PapC C-terminal domain; Region: PapC_C; pfam13953
321314001468	fimbrial chaperone protein StbB; Provisional; Region: PRK15249
321314001469	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314001470	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314001471	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
321314001472	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
321314001473	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
321314001474	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314001475	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
321314001476	DNA binding site [nucleotide binding]
321314001477	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
321314001478	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
321314001479	DNA binding residues [nucleotide binding]
321314001480	dimerization interface [polypeptide binding]; other site
321314001481	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
321314001482	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
321314001483	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
321314001484	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314001485	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314001486	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
321314001487	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
321314001488	DNA binding residues [nucleotide binding]
321314001489	dimer interface [polypeptide binding]; other site
321314001490	copper binding site [ion binding]; other site
321314001491	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
321314001492	metal-binding site [ion binding]
321314001493	putative sialic acid transporter; Region: 2A0112; TIGR00891
321314001494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001495	putative substrate translocation pore; other site
321314001496	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
321314001497	DNA methylase; Region: N6_N4_Mtase; cl17433
321314001498	DNA methylase; Region: N6_N4_Mtase; pfam01555
321314001499	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
321314001500	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
321314001501	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
321314001502	VRR-NUC domain; Region: VRR_NUC; pfam08774
321314001503	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
321314001504	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
321314001505	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
321314001506	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
321314001507	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314001508	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
321314001509	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314001510	N-terminal plug; other site
321314001511	ligand-binding site [chemical binding]; other site
321314001512	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
321314001513	hypothetical protein; Provisional; Region: PRK09929
321314001514	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
321314001515	Propionate catabolism activator; Region: PrpR_N; pfam06506
321314001516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314001517	Walker A motif; other site
321314001518	ATP binding site [chemical binding]; other site
321314001519	Walker B motif; other site
321314001520	arginine finger; other site
321314001521	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
321314001522	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
321314001523	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
321314001524	tetramer interface [polypeptide binding]; other site
321314001525	active site
321314001526	Mg2+/Mn2+ binding site [ion binding]; other site
321314001527	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
321314001528	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
321314001529	dimer interface [polypeptide binding]; other site
321314001530	active site
321314001531	citrylCoA binding site [chemical binding]; other site
321314001532	oxalacetate/citrate binding site [chemical binding]; other site
321314001533	coenzyme A binding site [chemical binding]; other site
321314001534	catalytic triad [active]
321314001535	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
321314001536	2-methylcitrate dehydratase; Region: prpD; TIGR02330
321314001537	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
321314001538	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
321314001539	acyl-activating enzyme (AAE) consensus motif; other site
321314001540	AMP binding site [chemical binding]; other site
321314001541	active site
321314001542	CoA binding site [chemical binding]; other site
321314001543	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
321314001544	dimer interface [polypeptide binding]; other site
321314001545	active site
321314001546	Schiff base residues; other site
321314001547	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
321314001548	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
321314001549	Autotransporter beta-domain; Region: Autotransporter; pfam03797
321314001550	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
321314001551	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
321314001552	ligand binding site [chemical binding]; other site
321314001553	flexible hinge region; other site
321314001554	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
321314001555	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
321314001556	microcin B17 transporter; Reviewed; Region: PRK11098
321314001557	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
321314001558	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
321314001559	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
321314001560	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
321314001561	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
321314001562	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
321314001563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
321314001564	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
321314001565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001566	putative substrate translocation pore; other site
321314001567	anti-RssB factor; Provisional; Region: PRK10244
321314001568	hypothetical protein; Provisional; Region: PRK11505
321314001569	psiF repeat; Region: PsiF_repeat; pfam07769
321314001570	psiF repeat; Region: PsiF_repeat; pfam07769
321314001571	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
321314001572	MASE2 domain; Region: MASE2; pfam05230
321314001573	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314001574	metal binding site [ion binding]; metal-binding site
321314001575	active site
321314001576	I-site; other site
321314001577	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
321314001578	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
321314001579	hypothetical protein; Validated; Region: PRK00124
321314001580	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
321314001581	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
321314001582	ADP binding site [chemical binding]; other site
321314001583	magnesium binding site [ion binding]; other site
321314001584	putative shikimate binding site; other site
321314001585	hypothetical protein; Provisional; Region: PRK10380
321314001586	hypothetical protein; Provisional; Region: PRK10481
321314001587	hypothetical protein; Provisional; Region: PRK10579
321314001588	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
321314001589	fructokinase; Reviewed; Region: PRK09557
321314001590	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314001591	nucleotide binding site [chemical binding]; other site
321314001592	MFS transport protein AraJ; Provisional; Region: PRK10091
321314001593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001594	putative substrate translocation pore; other site
321314001595	exonuclease subunit SbcC; Provisional; Region: PRK10246
321314001596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314001597	Walker A/P-loop; other site
321314001598	ATP binding site [chemical binding]; other site
321314001599	Q-loop/lid; other site
321314001600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314001601	ABC transporter signature motif; other site
321314001602	Walker B; other site
321314001603	D-loop; other site
321314001604	H-loop/switch region; other site
321314001605	exonuclease subunit SbcD; Provisional; Region: PRK10966
321314001606	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
321314001607	active site
321314001608	metal binding site [ion binding]; metal-binding site
321314001609	DNA binding site [nucleotide binding]
321314001610	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
321314001611	transcriptional regulator PhoB; Provisional; Region: PRK10161
321314001612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314001613	active site
321314001614	phosphorylation site [posttranslational modification]
321314001615	intermolecular recognition site; other site
321314001616	dimerization interface [polypeptide binding]; other site
321314001617	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314001618	DNA binding site [nucleotide binding]
321314001619	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
321314001620	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
321314001621	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314001622	putative active site [active]
321314001623	heme pocket [chemical binding]; other site
321314001624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314001625	dimer interface [polypeptide binding]; other site
321314001626	phosphorylation site [posttranslational modification]
321314001627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314001628	ATP binding site [chemical binding]; other site
321314001629	Mg2+ binding site [ion binding]; other site
321314001630	G-X-G motif; other site
321314001631	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
321314001632	putative proline-specific permease; Provisional; Region: proY; PRK10580
321314001633	Spore germination protein; Region: Spore_permease; cl17796
321314001634	maltodextrin glucosidase; Provisional; Region: PRK10785
321314001635	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
321314001636	homodimer interface [polypeptide binding]; other site
321314001637	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
321314001638	active site
321314001639	homodimer interface [polypeptide binding]; other site
321314001640	catalytic site [active]
321314001641	peroxidase; Provisional; Region: PRK15000
321314001642	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
321314001643	dimer interface [polypeptide binding]; other site
321314001644	decamer (pentamer of dimers) interface [polypeptide binding]; other site
321314001645	catalytic triad [active]
321314001646	peroxidatic and resolving cysteines [active]
321314001647	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
321314001648	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
321314001649	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
321314001650	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
321314001651	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
321314001652	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
321314001653	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
321314001654	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
321314001655	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
321314001656	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
321314001657	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
321314001658	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
321314001659	Protein export membrane protein; Region: SecD_SecF; pfam02355
321314001660	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
321314001661	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
321314001662	Predicted transcriptional regulator [Transcription]; Region: COG2378
321314001663	HTH domain; Region: HTH_11; pfam08279
321314001664	WYL domain; Region: WYL; pfam13280
321314001665	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
321314001666	active site
321314001667	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
321314001668	hypothetical protein; Provisional; Region: PRK11530
321314001669	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
321314001670	ATP cone domain; Region: ATP-cone; pfam03477
321314001671	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
321314001672	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
321314001673	catalytic motif [active]
321314001674	Zn binding site [ion binding]; other site
321314001675	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
321314001676	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
321314001677	homopentamer interface [polypeptide binding]; other site
321314001678	active site
321314001679	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
321314001680	putative RNA binding site [nucleotide binding]; other site
321314001681	thiamine monophosphate kinase; Provisional; Region: PRK05731
321314001682	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
321314001683	ATP binding site [chemical binding]; other site
321314001684	dimerization interface [polypeptide binding]; other site
321314001685	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
321314001686	tetramer interfaces [polypeptide binding]; other site
321314001687	binuclear metal-binding site [ion binding]; other site
321314001688	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314001689	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314001690	active site
321314001691	catalytic tetrad [active]
321314001692	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
321314001693	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
321314001694	TPP-binding site; other site
321314001695	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
321314001696	PYR/PP interface [polypeptide binding]; other site
321314001697	dimer interface [polypeptide binding]; other site
321314001698	TPP binding site [chemical binding]; other site
321314001699	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
321314001700	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
321314001701	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
321314001702	substrate binding pocket [chemical binding]; other site
321314001703	chain length determination region; other site
321314001704	substrate-Mg2+ binding site; other site
321314001705	catalytic residues [active]
321314001706	aspartate-rich region 1; other site
321314001707	active site lid residues [active]
321314001708	aspartate-rich region 2; other site
321314001709	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
321314001710	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
321314001711	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
321314001712	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
321314001713	Ligand Binding Site [chemical binding]; other site
321314001714	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
321314001715	active site residue [active]
321314001716	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
321314001717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314001718	dimer interface [polypeptide binding]; other site
321314001719	conserved gate region; other site
321314001720	ABC-ATPase subunit interface; other site
321314001721	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
321314001722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314001723	dimer interface [polypeptide binding]; other site
321314001724	conserved gate region; other site
321314001725	putative PBP binding loops; other site
321314001726	ABC-ATPase subunit interface; other site
321314001727	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
321314001728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314001729	Walker A/P-loop; other site
321314001730	ATP binding site [chemical binding]; other site
321314001731	Q-loop/lid; other site
321314001732	ABC transporter signature motif; other site
321314001733	Walker B; other site
321314001734	D-loop; other site
321314001735	H-loop/switch region; other site
321314001736	TOBE domain; Region: TOBE_2; pfam08402
321314001737	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
321314001738	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
321314001739	transcriptional regulator protein; Region: phnR; TIGR03337
321314001740	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314001741	DNA-binding site [nucleotide binding]; DNA binding site
321314001742	UTRA domain; Region: UTRA; pfam07702
321314001743	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
321314001744	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314001745	catalytic residue [active]
321314001746	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
321314001747	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314001748	motif II; other site
321314001749	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
321314001750	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
321314001751	conserved cys residue [active]
321314001752	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
321314001753	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
321314001754	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
321314001755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
321314001756	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
321314001757	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314001758	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001759	putative substrate translocation pore; other site
321314001760	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
321314001761	Sel1-like repeats; Region: SEL1; smart00671
321314001762	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314001763	Sel1 repeat; Region: Sel1; pfam08238
321314001764	Sel1-like repeats; Region: SEL1; smart00671
321314001765	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314001766	Sel1-like repeats; Region: SEL1; smart00671
321314001767	Sel1-like repeats; Region: SEL1; smart00671
321314001768	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
321314001769	UbiA prenyltransferase family; Region: UbiA; pfam01040
321314001770	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
321314001771	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
321314001772	Subunit I/III interface [polypeptide binding]; other site
321314001773	Subunit III/IV interface [polypeptide binding]; other site
321314001774	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
321314001775	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
321314001776	D-pathway; other site
321314001777	Putative ubiquinol binding site [chemical binding]; other site
321314001778	Low-spin heme (heme b) binding site [chemical binding]; other site
321314001779	Putative water exit pathway; other site
321314001780	Binuclear center (heme o3/CuB) [ion binding]; other site
321314001781	K-pathway; other site
321314001782	Putative proton exit pathway; other site
321314001783	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
321314001784	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
321314001785	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
321314001786	muropeptide transporter; Reviewed; Region: ampG; PRK11902
321314001787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001788	putative substrate translocation pore; other site
321314001789	hypothetical protein; Provisional; Region: PRK11627
321314001790	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
321314001791	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
321314001792	transcriptional regulator BolA; Provisional; Region: PRK11628
321314001793	trigger factor; Provisional; Region: tig; PRK01490
321314001794	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
321314001795	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
321314001796	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
321314001797	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
321314001798	oligomer interface [polypeptide binding]; other site
321314001799	active site residues [active]
321314001800	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
321314001801	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
321314001802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314001803	Walker A motif; other site
321314001804	ATP binding site [chemical binding]; other site
321314001805	Walker B motif; other site
321314001806	Iron permease FTR1 family; Region: FTR1; cl00475
321314001807	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
321314001808	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
321314001809	Found in ATP-dependent protease La (LON); Region: LON; smart00464
321314001810	Found in ATP-dependent protease La (LON); Region: LON; smart00464
321314001811	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314001812	Walker A motif; other site
321314001813	ATP binding site [chemical binding]; other site
321314001814	Walker B motif; other site
321314001815	arginine finger; other site
321314001816	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
321314001817	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
321314001818	IHF dimer interface [polypeptide binding]; other site
321314001819	IHF - DNA interface [nucleotide binding]; other site
321314001820	periplasmic folding chaperone; Provisional; Region: PRK10788
321314001821	SurA N-terminal domain; Region: SurA_N_3; cl07813
321314001822	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
321314001823	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
321314001824	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
321314001825	active site
321314001826	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
321314001827	Ligand Binding Site [chemical binding]; other site
321314001828	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
321314001829	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
321314001830	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
321314001831	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
321314001832	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314001833	active site
321314001834	motif I; other site
321314001835	motif II; other site
321314001836	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
321314001837	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
321314001838	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314001839	catalytic residue [active]
321314001840	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
321314001841	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314001842	putative DNA binding site [nucleotide binding]; other site
321314001843	putative Zn2+ binding site [ion binding]; other site
321314001844	AsnC family; Region: AsnC_trans_reg; pfam01037
321314001845	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
321314001846	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314001847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314001848	Walker A/P-loop; other site
321314001849	ATP binding site [chemical binding]; other site
321314001850	Q-loop/lid; other site
321314001851	ABC transporter signature motif; other site
321314001852	Walker B; other site
321314001853	D-loop; other site
321314001854	H-loop/switch region; other site
321314001855	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
321314001856	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314001857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314001858	Walker A/P-loop; other site
321314001859	ATP binding site [chemical binding]; other site
321314001860	Q-loop/lid; other site
321314001861	ABC transporter signature motif; other site
321314001862	Walker B; other site
321314001863	D-loop; other site
321314001864	H-loop/switch region; other site
321314001865	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
321314001866	Nitrogen regulatory protein P-II; Region: P-II; smart00938
321314001867	ammonium transporter; Provisional; Region: PRK10666
321314001868	acyl-CoA thioesterase II; Provisional; Region: PRK10526
321314001869	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
321314001870	active site
321314001871	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
321314001872	catalytic triad [active]
321314001873	dimer interface [polypeptide binding]; other site
321314001874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
321314001875	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
321314001876	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
321314001877	DNA binding site [nucleotide binding]
321314001878	active site
321314001879	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
321314001880	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
321314001881	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314001882	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
321314001883	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
321314001884	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
321314001885	maltose O-acetyltransferase; Provisional; Region: PRK10092
321314001886	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
321314001887	active site
321314001888	substrate binding site [chemical binding]; other site
321314001889	trimer interface [polypeptide binding]; other site
321314001890	CoA binding site [chemical binding]; other site
321314001891	gene expression modulator; Provisional; Region: PRK10945
321314001892	Hha toxicity attenuator; Provisional; Region: PRK10667
321314001893	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
321314001894	Protein export membrane protein; Region: SecD_SecF; cl14618
321314001895	Protein export membrane protein; Region: SecD_SecF; cl14618
321314001896	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
321314001897	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314001898	hypothetical protein; Provisional; Region: PRK11281
321314001899	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
321314001900	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
321314001901	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314001902	Uncharacterized conserved protein [Function unknown]; Region: COG5464
321314001903	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
321314001904	hypothetical protein; Provisional; Region: PRK11038
321314001905	primosomal replication protein N''; Provisional; Region: PRK10093
321314001906	hypothetical protein; Provisional; Region: PRK10527
321314001907	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314001908	active site
321314001909	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
321314001910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314001911	Walker A motif; other site
321314001912	ATP binding site [chemical binding]; other site
321314001913	Walker B motif; other site
321314001914	DNA polymerase III subunit delta'; Validated; Region: PRK08485
321314001915	arginine finger; other site
321314001916	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
321314001917	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
321314001918	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
321314001919	hypothetical protein; Validated; Region: PRK00153
321314001920	recombination protein RecR; Reviewed; Region: recR; PRK00076
321314001921	RecR protein; Region: RecR; pfam02132
321314001922	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
321314001923	putative active site [active]
321314001924	putative metal-binding site [ion binding]; other site
321314001925	tetramer interface [polypeptide binding]; other site
321314001926	heat shock protein 90; Provisional; Region: PRK05218
321314001927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314001928	ATP binding site [chemical binding]; other site
321314001929	Mg2+ binding site [ion binding]; other site
321314001930	G-X-G motif; other site
321314001931	adenylate kinase; Reviewed; Region: adk; PRK00279
321314001932	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
321314001933	AMP-binding site [chemical binding]; other site
321314001934	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
321314001935	ferrochelatase; Reviewed; Region: hemH; PRK00035
321314001936	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
321314001937	C-terminal domain interface [polypeptide binding]; other site
321314001938	active site
321314001939	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
321314001940	active site
321314001941	N-terminal domain interface [polypeptide binding]; other site
321314001942	acetyl esterase; Provisional; Region: PRK10162
321314001943	inosine/guanosine kinase; Provisional; Region: PRK15074
321314001944	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314001945	putative cation:proton antiport protein; Provisional; Region: PRK10669
321314001946	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
321314001947	TrkA-N domain; Region: TrkA_N; pfam02254
321314001948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314001949	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314001950	putative substrate translocation pore; other site
321314001951	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
321314001952	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
321314001953	active site
321314001954	metal binding site [ion binding]; metal-binding site
321314001955	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
321314001956	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
321314001957	putative deacylase active site [active]
321314001958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
321314001959	copper exporting ATPase; Provisional; Region: copA; PRK10671
321314001960	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
321314001961	metal-binding site [ion binding]
321314001962	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
321314001963	metal-binding site [ion binding]
321314001964	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
321314001965	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314001966	motif II; other site
321314001967	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
321314001968	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
321314001969	DNA binding residues [nucleotide binding]
321314001970	dimer interface [polypeptide binding]; other site
321314001971	copper binding site [ion binding]; other site
321314001972	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
321314001973	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
321314001974	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
321314001975	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
321314001976	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
321314001977	Walker A/P-loop; other site
321314001978	ATP binding site [chemical binding]; other site
321314001979	Q-loop/lid; other site
321314001980	ABC transporter signature motif; other site
321314001981	Walker B; other site
321314001982	D-loop; other site
321314001983	H-loop/switch region; other site
321314001984	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
321314001985	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
321314001986	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
321314001987	oxidoreductase; Provisional; Region: PRK08017
321314001988	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
321314001989	NADP binding site [chemical binding]; other site
321314001990	active site
321314001991	steroid binding site; other site
321314001992	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
321314001993	active site
321314001994	catalytic triad [active]
321314001995	oxyanion hole [active]
321314001996	switch loop; other site
321314001997	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
321314001998	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
321314001999	Walker A/P-loop; other site
321314002000	ATP binding site [chemical binding]; other site
321314002001	Q-loop/lid; other site
321314002002	ABC transporter signature motif; other site
321314002003	Walker B; other site
321314002004	D-loop; other site
321314002005	H-loop/switch region; other site
321314002006	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
321314002007	FtsX-like permease family; Region: FtsX; pfam02687
321314002008	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314002009	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
321314002010	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
321314002011	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
321314002012	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
321314002013	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
321314002014	Walker A/P-loop; other site
321314002015	ATP binding site [chemical binding]; other site
321314002016	Q-loop/lid; other site
321314002017	ABC transporter signature motif; other site
321314002018	Walker B; other site
321314002019	D-loop; other site
321314002020	H-loop/switch region; other site
321314002021	NIL domain; Region: NIL; pfam09383
321314002022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314002023	dimer interface [polypeptide binding]; other site
321314002024	conserved gate region; other site
321314002025	ABC-ATPase subunit interface; other site
321314002026	Predicted ATPase [General function prediction only]; Region: COG2603
321314002027	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
321314002028	active site residue [active]
321314002029	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
321314002030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314002031	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314002032	dimerization interface [polypeptide binding]; other site
321314002033	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
321314002034	ureidoglycolate hydrolase; Provisional; Region: PRK03606
321314002035	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
321314002036	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
321314002037	Bacterial transcriptional regulator; Region: IclR; pfam01614
321314002038	hydroxypyruvate isomerase; Provisional; Region: PRK09997
321314002039	tartronate semialdehyde reductase; Provisional; Region: PRK15059
321314002040	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
321314002041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314002042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314002043	putative substrate translocation pore; other site
321314002044	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
321314002045	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
321314002046	Na binding site [ion binding]; other site
321314002047	putative substrate binding site [chemical binding]; other site
321314002048	allantoinase; Provisional; Region: PRK08044
321314002049	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
321314002050	active site
321314002051	putative uracil/xanthine transporter; Provisional; Region: PRK11412
321314002052	glycerate kinase II; Provisional; Region: PRK09932
321314002053	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
321314002054	Mif2/CENP-C like; Region: Mif2; pfam11699
321314002055	Cupin domain; Region: Cupin_2; pfam07883
321314002056	allantoate amidohydrolase; Region: AllC; TIGR03176
321314002057	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
321314002058	active site
321314002059	metal binding site [ion binding]; metal-binding site
321314002060	dimer interface [polypeptide binding]; other site
321314002061	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
321314002062	membrane protein FdrA; Validated; Region: PRK06091
321314002063	CoA binding domain; Region: CoA_binding; pfam02629
321314002064	CoA-ligase; Region: Ligase_CoA; pfam00549
321314002065	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
321314002066	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
321314002067	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
321314002068	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
321314002069	putative substrate binding site [chemical binding]; other site
321314002070	nucleotide binding site [chemical binding]; other site
321314002071	nucleotide binding site [chemical binding]; other site
321314002072	homodimer interface [polypeptide binding]; other site
321314002073	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
321314002074	ATP-grasp domain; Region: ATP-grasp; pfam02222
321314002075	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
321314002076	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
321314002077	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
321314002078	putative active site [active]
321314002079	putative metal binding site [ion binding]; other site
321314002080	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
321314002081	substrate binding site [chemical binding]; other site
321314002082	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
321314002083	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
321314002084	active site
321314002085	HIGH motif; other site
321314002086	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
321314002087	KMSKS motif; other site
321314002088	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
321314002089	tRNA binding surface [nucleotide binding]; other site
321314002090	anticodon binding site; other site
321314002091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
321314002092	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
321314002093	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
321314002094	ribosome-associated protein; Provisional; Region: PRK11507
321314002095	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
321314002096	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
321314002097	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
321314002098	homodimer interface [polypeptide binding]; other site
321314002099	NADP binding site [chemical binding]; other site
321314002100	substrate binding site [chemical binding]; other site
321314002101	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
321314002102	fimbrial protein FimI; Provisional; Region: PRK15200
321314002103	similar to Tn10
321314002104	outer membrane usher protein FimD; Provisional; Region: PRK15198
321314002105	PapC N-terminal domain; Region: PapC_N; pfam13954
321314002106	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314002107	PapC C-terminal domain; Region: PapC_C; pfam13953
321314002108	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
321314002109	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
321314002110	transcriptional regulator FimZ; Provisional; Region: PRK09935
321314002111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314002112	active site
321314002113	phosphorylation site [posttranslational modification]
321314002114	intermolecular recognition site; other site
321314002115	dimerization interface [polypeptide binding]; other site
321314002116	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314002117	DNA binding residues [nucleotide binding]
321314002118	dimerization interface [polypeptide binding]; other site
321314002119	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
321314002120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
321314002121	DNA binding residues [nucleotide binding]
321314002122	dimerization interface [polypeptide binding]; other site
321314002123	similar to IS285
321314002124	similar to IS285
321314002125	similar to IS285
321314002126	Predicted membrane protein [Function unknown]; Region: COG2246
321314002127	GtrA-like protein; Region: GtrA; pfam04138
321314002128	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
321314002129	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
321314002130	Ligand binding site; other site
321314002131	Putative Catalytic site; other site
321314002132	DXD motif; other site
321314002133	similar to IS285
321314002134	similar to IS285
321314002135	similar to IS285
321314002136	similar to IS285
321314002137	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
321314002138	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
321314002139	Ligand binding site; other site
321314002140	Putative Catalytic site; other site
321314002141	DXD motif; other site
321314002142	Predicted membrane protein [Function unknown]; Region: COG2246
321314002143	GtrA-like protein; Region: GtrA; pfam04138
321314002144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314002145	ATP binding site [chemical binding]; other site
321314002146	Mg2+ binding site [ion binding]; other site
321314002147	G-X-G motif; other site
321314002148	Cupin; Region: Cupin_6; pfam12852
321314002149	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
321314002150	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314002151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314002152	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
321314002153	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314002154	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
321314002155	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314002156	Predicted membrane protein [Function unknown]; Region: COG3059
321314002157	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
321314002158	phenylalanine transporter; Provisional; Region: PRK10249
321314002159	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
321314002160	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314002161	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
321314002162	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
321314002163	active site
321314002164	oxyanion hole [active]
321314002165	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
321314002166	catalytic triad [active]
321314002167	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
321314002168	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
321314002169	dimer interface [polypeptide binding]; other site
321314002170	FMN binding site [chemical binding]; other site
321314002171	hypothetical protein; Provisional; Region: PRK10250
321314002172	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
321314002173	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314002174	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
321314002175	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314002176	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
321314002177	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
321314002178	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
321314002179	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
321314002180	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
321314002181	outer membrane receptor FepA; Provisional; Region: PRK13524
321314002182	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314002183	N-terminal plug; other site
321314002184	ligand-binding site [chemical binding]; other site
321314002185	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
321314002186	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
321314002187	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
321314002188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
321314002189	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
321314002190	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
321314002191	acyl-activating enzyme (AAE) consensus motif; other site
321314002192	AMP binding site [chemical binding]; other site
321314002193	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
321314002194	LPS O-antigen length regulator; Provisional; Region: PRK10381
321314002195	Chain length determinant protein; Region: Wzz; pfam02706
321314002196	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
321314002197	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
321314002198	Walker A/P-loop; other site
321314002199	ATP binding site [chemical binding]; other site
321314002200	Q-loop/lid; other site
321314002201	ABC transporter signature motif; other site
321314002202	Walker B; other site
321314002203	D-loop; other site
321314002204	H-loop/switch region; other site
321314002205	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
321314002206	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314002207	ABC-ATPase subunit  interface; other site
321314002208	dimer interface [polypeptide binding]; other site
321314002209	putative PBP binding regions; other site
321314002210	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
321314002211	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314002212	ABC-ATPase subunit  interface; other site
321314002213	dimer interface [polypeptide binding]; other site
321314002214	putative PBP binding regions; other site
321314002215	enterobactin exporter EntS; Provisional; Region: PRK10489
321314002216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314002217	putative substrate translocation pore; other site
321314002218	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
321314002219	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
321314002220	siderophore binding site; other site
321314002221	isochorismate synthase EntC; Provisional; Region: PRK15016
321314002222	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
321314002223	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
321314002224	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
321314002225	acyl-activating enzyme (AAE) consensus motif; other site
321314002226	active site
321314002227	AMP binding site [chemical binding]; other site
321314002228	substrate binding site [chemical binding]; other site
321314002229	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
321314002230	hydrophobic substrate binding pocket; other site
321314002231	Isochorismatase family; Region: Isochorismatase; pfam00857
321314002232	active site
321314002233	conserved cis-peptide bond; other site
321314002234	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
321314002235	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
321314002236	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
321314002237	putative NAD(P) binding site [chemical binding]; other site
321314002238	active site
321314002239	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
321314002240	CoenzymeA binding site [chemical binding]; other site
321314002241	subunit interaction site [polypeptide binding]; other site
321314002242	PHB binding site; other site
321314002243	carbon starvation protein A; Provisional; Region: PRK15015
321314002244	Carbon starvation protein CstA; Region: CstA; pfam02554
321314002245	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
321314002246	Uncharacterized small protein [Function unknown]; Region: COG2879
321314002247	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
321314002248	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
321314002249	putative active site [active]
321314002250	metal binding site [ion binding]; metal-binding site
321314002251	methionine aminotransferase; Validated; Region: PRK09082
321314002252	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314002253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314002254	homodimer interface [polypeptide binding]; other site
321314002255	catalytic residue [active]
321314002256	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
321314002257	ParB-like nuclease domain; Region: ParBc; pfam02195
321314002258	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
321314002259	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
321314002260	Active Sites [active]
321314002261	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
321314002262	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
321314002263	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314002264	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314002265	dimerization interface [polypeptide binding]; other site
321314002266	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
321314002267	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
321314002268	dimerization domain [polypeptide binding]; other site
321314002269	dimer interface [polypeptide binding]; other site
321314002270	catalytic residues [active]
321314002271	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
321314002272	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
321314002273	dimer interface [polypeptide binding]; other site
321314002274	decamer (pentamer of dimers) interface [polypeptide binding]; other site
321314002275	catalytic triad [active]
321314002276	peroxidatic and resolving cysteines [active]
321314002277	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
321314002278	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
321314002279	catalytic residue [active]
321314002280	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
321314002281	catalytic residues [active]
321314002282	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314002283	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314002284	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
321314002285	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
321314002286	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
321314002287	putative [4Fe-4S] binding site [ion binding]; other site
321314002288	putative molybdopterin cofactor binding site [chemical binding]; other site
321314002289	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
321314002290	molybdopterin cofactor binding site; other site
321314002291	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
321314002292	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
321314002293	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
321314002294	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
321314002295	Ligand Binding Site [chemical binding]; other site
321314002296	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
321314002297	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
321314002298	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
321314002299	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
321314002300	transmembrane helices; other site
321314002301	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
321314002302	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
321314002303	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
321314002304	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
321314002305	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
321314002306	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
321314002307	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
321314002308	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
321314002309	putative active site [active]
321314002310	(T/H)XGH motif; other site
321314002311	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
321314002312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314002313	putative active site [active]
321314002314	heme pocket [chemical binding]; other site
321314002315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314002316	ATP binding site [chemical binding]; other site
321314002317	Mg2+ binding site [ion binding]; other site
321314002318	G-X-G motif; other site
321314002319	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
321314002320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314002321	active site
321314002322	phosphorylation site [posttranslational modification]
321314002323	intermolecular recognition site; other site
321314002324	dimerization interface [polypeptide binding]; other site
321314002325	Transcriptional regulator; Region: CitT; pfam12431
321314002326	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
321314002327	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
321314002328	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
321314002329	DNA-binding site [nucleotide binding]; DNA binding site
321314002330	RNA-binding motif; other site
321314002331	chromosome condensation membrane protein; Provisional; Region: PRK14196
321314002332	Predicted amidohydrolase [General function prediction only]; Region: COG0388
321314002333	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
321314002334	putative active site [active]
321314002335	catalytic triad [active]
321314002336	putative dimer interface [polypeptide binding]; other site
321314002337	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
321314002338	lipoyl synthase; Provisional; Region: PRK05481
321314002339	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314002340	FeS/SAM binding site; other site
321314002341	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
321314002342	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314002343	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
321314002344	substrate binding pocket [chemical binding]; other site
321314002345	dimerization interface [polypeptide binding]; other site
321314002346	lipoate-protein ligase B; Provisional; Region: PRK14342
321314002347	hypothetical protein; Provisional; Region: PRK04998
321314002348	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
321314002349	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
321314002350	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
321314002351	rare lipoprotein A; Provisional; Region: PRK10672
321314002352	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
321314002353	Sporulation related domain; Region: SPOR; pfam05036
321314002354	cell wall shape-determining protein; Provisional; Region: PRK10794
321314002355	penicillin-binding protein 2; Provisional; Region: PRK10795
321314002356	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
321314002357	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
321314002358	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
321314002359	ribosome-associated protein; Provisional; Region: PRK11538
321314002360	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
321314002361	catalytic core [active]
321314002362	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
321314002363	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314002364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314002365	homodimer interface [polypeptide binding]; other site
321314002366	catalytic residue [active]
321314002367	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
321314002368	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
321314002369	active site
321314002370	(T/H)XGH motif; other site
321314002371	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
321314002372	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
321314002373	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
321314002374	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
321314002375	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
321314002376	HIGH motif; other site
321314002377	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
321314002378	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
321314002379	active site
321314002380	KMSKS motif; other site
321314002381	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
321314002382	tRNA binding surface [nucleotide binding]; other site
321314002383	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
321314002384	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
321314002385	Propionate catabolism activator; Region: PrpR_N; pfam06506
321314002386	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
321314002387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314002388	Walker A motif; other site
321314002389	ATP binding site [chemical binding]; other site
321314002390	Walker B motif; other site
321314002391	arginine finger; other site
321314002392	hypothetical protein; Provisional; Region: PRK11032
321314002393	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
321314002394	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314002395	Sel1-like repeats; Region: SEL1; smart00671
321314002396	Sel1-like repeats; Region: SEL1; smart00671
321314002397	Sel1-like repeats; Region: SEL1; smart00671
321314002398	Sel1-like repeats; Region: SEL1; smart00671
321314002399	Sel1-like repeats; Region: SEL1; smart00671
321314002400	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
321314002401	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
321314002402	HSP70 interaction site [polypeptide binding]; other site
321314002403	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
321314002404	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
321314002405	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
321314002406	nucleotide binding site [chemical binding]; other site
321314002407	putative NEF/HSP70 interaction site [polypeptide binding]; other site
321314002408	SBD interface [polypeptide binding]; other site
321314002409	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
321314002410	active site
321314002411	tetramer interface [polypeptide binding]; other site
321314002412	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
321314002413	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
321314002414	Walker A/P-loop; other site
321314002415	ATP binding site [chemical binding]; other site
321314002416	Q-loop/lid; other site
321314002417	ABC transporter signature motif; other site
321314002418	Walker B; other site
321314002419	D-loop; other site
321314002420	H-loop/switch region; other site
321314002421	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314002422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314002423	dimer interface [polypeptide binding]; other site
321314002424	conserved gate region; other site
321314002425	putative PBP binding loops; other site
321314002426	ABC-ATPase subunit interface; other site
321314002427	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314002428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314002429	dimer interface [polypeptide binding]; other site
321314002430	conserved gate region; other site
321314002431	putative PBP binding loops; other site
321314002432	ABC-ATPase subunit interface; other site
321314002433	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
321314002434	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314002435	substrate binding pocket [chemical binding]; other site
321314002436	membrane-bound complex binding site; other site
321314002437	hinge residues; other site
321314002438	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
321314002439	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
321314002440	putative active site [active]
321314002441	catalytic triad [active]
321314002442	putative dimer interface [polypeptide binding]; other site
321314002443	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
321314002444	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
321314002445	Transporter associated domain; Region: CorC_HlyC; smart01091
321314002446	metal-binding heat shock protein; Provisional; Region: PRK00016
321314002447	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
321314002448	PhoH-like protein; Region: PhoH; pfam02562
321314002449	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
321314002450	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
321314002451	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314002452	FeS/SAM binding site; other site
321314002453	TRAM domain; Region: TRAM; pfam01938
321314002454	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
321314002455	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
321314002456	asparagine synthetase B; Provisional; Region: asnB; PRK09431
321314002457	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
321314002458	active site
321314002459	dimer interface [polypeptide binding]; other site
321314002460	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
321314002461	Ligand Binding Site [chemical binding]; other site
321314002462	Molecular Tunnel; other site
321314002463	UMP phosphatase; Provisional; Region: PRK10444
321314002464	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314002465	active site
321314002466	motif I; other site
321314002467	motif II; other site
321314002468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314002469	MarR family; Region: MarR; pfam01047
321314002470	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
321314002471	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314002472	nucleotide binding site [chemical binding]; other site
321314002473	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
321314002474	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
321314002475	active site
321314002476	dimer interface [polypeptide binding]; other site
321314002477	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
321314002478	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
321314002479	active site
321314002480	trimer interface [polypeptide binding]; other site
321314002481	allosteric site; other site
321314002482	active site lid [active]
321314002483	hexamer (dimer of trimers) interface [polypeptide binding]; other site
321314002484	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
321314002485	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
321314002486	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
321314002487	active site turn [active]
321314002488	phosphorylation site [posttranslational modification]
321314002489	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
321314002490	HPr interaction site; other site
321314002491	glycerol kinase (GK) interaction site [polypeptide binding]; other site
321314002492	active site
321314002493	phosphorylation site [posttranslational modification]
321314002494	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
321314002495	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
321314002496	active site
321314002497	HIGH motif; other site
321314002498	nucleotide binding site [chemical binding]; other site
321314002499	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
321314002500	KMSKS motif; other site
321314002501	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
321314002502	outer membrane porin, OprD family; Region: OprD; pfam03573
321314002503	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
321314002504	YbfN-like lipoprotein; Region: YbfN; pfam13982
321314002505	citrate-proton symporter; Provisional; Region: PRK15075
321314002506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314002507	putative substrate translocation pore; other site
321314002508	tricarballylate dehydrogenase; Validated; Region: PRK08274
321314002509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314002510	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314002511	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314002512	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
321314002513	putative dimerization interface [polypeptide binding]; other site
321314002514	ferric uptake regulator; Provisional; Region: fur; PRK09462
321314002515	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
321314002516	metal binding site 2 [ion binding]; metal-binding site
321314002517	putative DNA binding helix; other site
321314002518	metal binding site 1 [ion binding]; metal-binding site
321314002519	dimer interface [polypeptide binding]; other site
321314002520	structural Zn2+ binding site [ion binding]; other site
321314002521	flavodoxin FldA; Validated; Region: PRK09267
321314002522	LexA regulated protein; Provisional; Region: PRK11675
321314002523	acyl-CoA esterase; Provisional; Region: PRK10673
321314002524	PGAP1-like protein; Region: PGAP1; pfam07819
321314002525	replication initiation regulator SeqA; Provisional; Region: PRK11187
321314002526	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
321314002527	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
321314002528	active site
321314002529	substrate binding site [chemical binding]; other site
321314002530	metal binding site [ion binding]; metal-binding site
321314002531	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
321314002532	putrescine transporter; Provisional; Region: potE; PRK10655
321314002533	ornithine decarboxylase; Provisional; Region: PRK13578
321314002534	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
321314002535	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
321314002536	homodimer interface [polypeptide binding]; other site
321314002537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314002538	catalytic residue [active]
321314002539	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
321314002540	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
321314002541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314002542	active site
321314002543	phosphorylation site [posttranslational modification]
321314002544	intermolecular recognition site; other site
321314002545	dimerization interface [polypeptide binding]; other site
321314002546	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314002547	DNA binding site [nucleotide binding]
321314002548	sensor protein KdpD; Provisional; Region: PRK10490
321314002549	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
321314002550	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
321314002551	Ligand Binding Site [chemical binding]; other site
321314002552	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
321314002553	GAF domain; Region: GAF_3; pfam13492
321314002554	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314002555	dimer interface [polypeptide binding]; other site
321314002556	phosphorylation site [posttranslational modification]
321314002557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314002558	ATP binding site [chemical binding]; other site
321314002559	Mg2+ binding site [ion binding]; other site
321314002560	G-X-G motif; other site
321314002561	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
321314002562	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
321314002563	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
321314002564	Soluble P-type ATPase [General function prediction only]; Region: COG4087
321314002565	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
321314002566	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
321314002567	DNA photolyase; Region: DNA_photolyase; pfam00875
321314002568	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
321314002569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314002570	putative substrate translocation pore; other site
321314002571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314002572	Uncharacterized conserved protein [Function unknown]; Region: COG0327
321314002573	metal-binding protein; Provisional; Region: PRK10799
321314002574	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
321314002575	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
321314002576	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
321314002577	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
321314002578	putative active site [active]
321314002579	endonuclease VIII; Provisional; Region: PRK10445
321314002580	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
321314002581	DNA binding site [nucleotide binding]
321314002582	catalytic residue [active]
321314002583	putative catalytic residues [active]
321314002584	H2TH interface [polypeptide binding]; other site
321314002585	intercalation triad [nucleotide binding]; other site
321314002586	substrate specificity determining residue; other site
321314002587	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
321314002588	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
321314002589	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
321314002590	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
321314002591	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
321314002592	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
321314002593	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
321314002594	dimer interface [polypeptide binding]; other site
321314002595	active site
321314002596	citrylCoA binding site [chemical binding]; other site
321314002597	NADH binding [chemical binding]; other site
321314002598	cationic pore residues; other site
321314002599	oxalacetate/citrate binding site [chemical binding]; other site
321314002600	coenzyme A binding site [chemical binding]; other site
321314002601	catalytic triad [active]
321314002602	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
321314002603	Iron-sulfur protein interface; other site
321314002604	proximal quinone binding site [chemical binding]; other site
321314002605	SdhD (CybS) interface [polypeptide binding]; other site
321314002606	proximal heme binding site [chemical binding]; other site
321314002607	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
321314002608	L-aspartate oxidase; Provisional; Region: PRK06175
321314002609	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
321314002610	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
321314002611	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
321314002612	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
321314002613	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
321314002614	TPP-binding site [chemical binding]; other site
321314002615	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
321314002616	dimer interface [polypeptide binding]; other site
321314002617	PYR/PP interface [polypeptide binding]; other site
321314002618	TPP binding site [chemical binding]; other site
321314002619	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
321314002620	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
321314002621	E3 interaction surface; other site
321314002622	lipoyl attachment site [posttranslational modification]; other site
321314002623	e3 binding domain; Region: E3_binding; pfam02817
321314002624	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
321314002625	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
321314002626	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
321314002627	CoA-ligase; Region: Ligase_CoA; pfam00549
321314002628	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
321314002629	CoA binding domain; Region: CoA_binding; smart00881
321314002630	CoA-ligase; Region: Ligase_CoA; pfam00549
321314002631	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
321314002632	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
321314002633	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
321314002634	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
321314002635	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
321314002636	hypothetical protein; Provisional; Region: PRK10588
321314002637	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
321314002638	active site
321314002639	colicin uptake protein TolQ; Provisional; Region: PRK10801
321314002640	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
321314002641	colicin uptake protein TolR; Provisional; Region: PRK11024
321314002642	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
321314002643	TolA C-terminal; Region: TolA; pfam06519
321314002644	translocation protein TolB; Provisional; Region: tolB; PRK03629
321314002645	TolB amino-terminal domain; Region: TolB_N; pfam04052
321314002646	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
321314002647	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
321314002648	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
321314002649	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
321314002650	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
321314002651	ligand binding site [chemical binding]; other site
321314002652	tol-pal system protein YbgF; Provisional; Region: PRK10803
321314002653	Tetratricopeptide repeat; Region: TPR_6; pfam13174
321314002654	Tetratricopeptide repeat; Region: TPR_6; pfam13174
321314002655	quinolinate synthetase; Provisional; Region: PRK09375
321314002656	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
321314002657	zinc transporter ZitB; Provisional; Region: PRK03557
321314002658	YbgS-like protein; Region: YbgS; pfam13985
321314002659	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
321314002660	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
321314002661	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
321314002662	fumarate hydratase; Provisional; Region: PRK06246
321314002663	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314002664	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314002665	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
321314002666	dimerization interface [polypeptide binding]; other site
321314002667	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
321314002668	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
321314002669	transmembrane helices; other site
321314002670	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
321314002671	oxaloacetate decarboxylase; Provisional; Region: PRK14040
321314002672	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
321314002673	active site
321314002674	catalytic residues [active]
321314002675	metal binding site [ion binding]; metal-binding site
321314002676	homodimer binding site [polypeptide binding]; other site
321314002677	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
321314002678	carboxyltransferase (CT) interaction site; other site
321314002679	biotinylation site [posttranslational modification]; other site
321314002680	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
321314002681	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
321314002682	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
321314002683	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314002684	dimer interface [polypeptide binding]; other site
321314002685	putative PBP binding regions; other site
321314002686	ABC-ATPase subunit  interface; other site
321314002687	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
321314002688	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
321314002689	Walker A/P-loop; other site
321314002690	ATP binding site [chemical binding]; other site
321314002691	Q-loop/lid; other site
321314002692	ABC transporter signature motif; other site
321314002693	Walker B; other site
321314002694	D-loop; other site
321314002695	H-loop/switch region; other site
321314002696	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
321314002697	catalytic core [active]
321314002698	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
321314002699	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
321314002700	active site
321314002701	catalytic residues [active]
321314002702	galactokinase; Provisional; Region: PRK05101
321314002703	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
321314002704	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
321314002705	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
321314002706	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
321314002707	dimer interface [polypeptide binding]; other site
321314002708	active site
321314002709	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
321314002710	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
321314002711	NAD binding site [chemical binding]; other site
321314002712	homodimer interface [polypeptide binding]; other site
321314002713	active site
321314002714	substrate binding site [chemical binding]; other site
321314002715	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
321314002716	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
321314002717	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314002718	Walker A/P-loop; other site
321314002719	ATP binding site [chemical binding]; other site
321314002720	Q-loop/lid; other site
321314002721	ABC transporter signature motif; other site
321314002722	Walker B; other site
321314002723	D-loop; other site
321314002724	H-loop/switch region; other site
321314002725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314002726	Walker A/P-loop; other site
321314002727	ATP binding site [chemical binding]; other site
321314002728	Q-loop/lid; other site
321314002729	ABC transporter signature motif; other site
321314002730	Walker B; other site
321314002731	D-loop; other site
321314002732	H-loop/switch region; other site
321314002733	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
321314002734	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
321314002735	molybdenum-pterin binding domain; Region: Mop; TIGR00638
321314002736	TOBE domain; Region: TOBE; pfam03459
321314002737	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
321314002738	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
321314002739	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314002740	substrate binding pocket [chemical binding]; other site
321314002741	membrane-bound complex binding site; other site
321314002742	hinge residues; other site
321314002743	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
321314002744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314002745	dimer interface [polypeptide binding]; other site
321314002746	conserved gate region; other site
321314002747	putative PBP binding loops; other site
321314002748	ABC-ATPase subunit interface; other site
321314002749	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
321314002750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314002751	Walker A/P-loop; other site
321314002752	ATP binding site [chemical binding]; other site
321314002753	Q-loop/lid; other site
321314002754	ABC transporter signature motif; other site
321314002755	Walker B; other site
321314002756	D-loop; other site
321314002757	H-loop/switch region; other site
321314002758	molybdenum-pterin binding domain; Region: Mop; TIGR00638
321314002759	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
321314002760	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314002761	active site
321314002762	motif I; other site
321314002763	motif II; other site
321314002764	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314002765	6-phosphogluconolactonase; Provisional; Region: PRK11028
321314002766	acyl-CoA thioesterase; Provisional; Region: PRK10531
321314002767	putative pectinesterase; Region: PLN02432; cl01911
321314002768	imidazolonepropionase; Validated; Region: PRK09356
321314002769	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
321314002770	active site
321314002771	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
321314002772	putative active site [active]
321314002773	putative metal binding site [ion binding]; other site
321314002774	histidine utilization repressor; Provisional; Region: PRK14999
321314002775	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314002776	DNA-binding site [nucleotide binding]; DNA binding site
321314002777	UTRA domain; Region: UTRA; pfam07702
321314002778	urocanate hydratase; Provisional; Region: PRK05414
321314002779	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
321314002780	active sites [active]
321314002781	tetramer interface [polypeptide binding]; other site
321314002782	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
321314002783	substrate binding site [chemical binding]; other site
321314002784	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
321314002785	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
321314002786	inhibitor-cofactor binding pocket; inhibition site
321314002787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314002788	catalytic residue [active]
321314002789	biotin synthase; Provisional; Region: PRK15108
321314002790	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314002791	FeS/SAM binding site; other site
321314002792	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
321314002793	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
321314002794	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
321314002795	substrate-cofactor binding pocket; other site
321314002796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314002797	catalytic residue [active]
321314002798	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
321314002799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314002800	S-adenosylmethionine binding site [chemical binding]; other site
321314002801	AAA domain; Region: AAA_26; pfam13500
321314002802	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
321314002803	excinuclease ABC subunit B; Provisional; Region: PRK05298
321314002804	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314002805	ATP binding site [chemical binding]; other site
321314002806	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314002807	nucleotide binding region [chemical binding]; other site
321314002808	ATP-binding site [chemical binding]; other site
321314002809	Ultra-violet resistance protein B; Region: UvrB; pfam12344
321314002810	UvrB/uvrC motif; Region: UVR; pfam02151
321314002811	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
321314002812	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
321314002813	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
321314002814	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
321314002815	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
321314002816	putative substrate binding pocket [chemical binding]; other site
321314002817	dimer interface [polypeptide binding]; other site
321314002818	phosphate binding site [ion binding]; other site
321314002819	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
321314002820	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314002821	FeS/SAM binding site; other site
321314002822	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
321314002823	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
321314002824	MPT binding site; other site
321314002825	trimer interface [polypeptide binding]; other site
321314002826	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
321314002827	trimer interface [polypeptide binding]; other site
321314002828	dimer interface [polypeptide binding]; other site
321314002829	putative active site [active]
321314002830	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
321314002831	MoaE interaction surface [polypeptide binding]; other site
321314002832	MoeB interaction surface [polypeptide binding]; other site
321314002833	thiocarboxylated glycine; other site
321314002834	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
321314002835	MoaE homodimer interface [polypeptide binding]; other site
321314002836	MoaD interaction [polypeptide binding]; other site
321314002837	active site residues [active]
321314002838	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
321314002839	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
321314002840	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
321314002841	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
321314002842	Predicted integral membrane protein [Function unknown]; Region: COG0392
321314002843	cardiolipin synthase 2; Provisional; Region: PRK11263
321314002844	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
321314002845	putative active site [active]
321314002846	catalytic site [active]
321314002847	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
321314002848	putative active site [active]
321314002849	catalytic site [active]
321314002850	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
321314002851	putative catalytic site [active]
321314002852	putative metal binding site [ion binding]; other site
321314002853	putative phosphate binding site [ion binding]; other site
321314002854	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
321314002855	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
321314002856	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
321314002857	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
321314002858	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
321314002859	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
321314002860	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
321314002861	Walker A/P-loop; other site
321314002862	ATP binding site [chemical binding]; other site
321314002863	Q-loop/lid; other site
321314002864	ABC transporter signature motif; other site
321314002865	Walker B; other site
321314002866	D-loop; other site
321314002867	H-loop/switch region; other site
321314002868	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
321314002869	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
321314002870	Walker A/P-loop; other site
321314002871	ATP binding site [chemical binding]; other site
321314002872	Q-loop/lid; other site
321314002873	ABC transporter signature motif; other site
321314002874	Walker B; other site
321314002875	D-loop; other site
321314002876	H-loop/switch region; other site
321314002877	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
321314002878	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
321314002879	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314002880	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
321314002881	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314002882	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
321314002883	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
321314002884	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
321314002885	ATP binding site [chemical binding]; other site
321314002886	Mg++ binding site [ion binding]; other site
321314002887	motif III; other site
321314002888	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314002889	nucleotide binding region [chemical binding]; other site
321314002890	ATP-binding site [chemical binding]; other site
321314002891	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
321314002892	DEAD_2; Region: DEAD_2; pfam06733
321314002893	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
321314002894	glycosyl transferase family protein; Provisional; Region: PRK08136
321314002895	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
321314002896	hypothetical protein; Provisional; Region: PRK10259
321314002897	hypothetical protein; Provisional; Region: PRK11019
321314002898	putative mechanosensitive channel protein; Provisional; Region: PRK11465
321314002899	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314002900	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
321314002901	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
321314002902	Walker A/P-loop; other site
321314002903	ATP binding site [chemical binding]; other site
321314002904	Q-loop/lid; other site
321314002905	ABC transporter signature motif; other site
321314002906	Walker B; other site
321314002907	D-loop; other site
321314002908	H-loop/switch region; other site
321314002909	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314002910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314002911	dimer interface [polypeptide binding]; other site
321314002912	conserved gate region; other site
321314002913	putative PBP binding loops; other site
321314002914	ABC-ATPase subunit interface; other site
321314002915	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
321314002916	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314002917	substrate binding pocket [chemical binding]; other site
321314002918	membrane-bound complex binding site; other site
321314002919	hinge residues; other site
321314002920	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
321314002921	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
321314002922	dimerization interface [polypeptide binding]; other site
321314002923	DPS ferroxidase diiron center [ion binding]; other site
321314002924	ion pore; other site
321314002925	threonine and homoserine efflux system; Provisional; Region: PRK10532
321314002926	EamA-like transporter family; Region: EamA; pfam00892
321314002927	outer membrane protein X; Provisional; Region: ompX; PRK09408
321314002928	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
321314002929	Sulfatase; Region: Sulfatase; pfam00884
321314002930	manganese transport regulator MntR; Provisional; Region: PRK11050
321314002931	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
321314002932	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
321314002933	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
321314002934	transmembrane helices; other site
321314002935	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
321314002936	L,D-transpeptidase; Provisional; Region: PRK10260
321314002937	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
321314002938	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
321314002939	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314002940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314002941	Walker A/P-loop; other site
321314002942	ATP binding site [chemical binding]; other site
321314002943	ABC transporter signature motif; other site
321314002944	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314002945	Walker B; other site
321314002946	ABC transporter; Region: ABC_tran_2; pfam12848
321314002947	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314002948	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
321314002949	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
321314002950	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314002951	active site
321314002952	motif I; other site
321314002953	motif II; other site
321314002954	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314002955	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
321314002956	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
321314002957	dimer interface [polypeptide binding]; other site
321314002958	active site
321314002959	glycine loop; other site
321314002960	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
321314002961	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314002962	FeS/SAM binding site; other site
321314002963	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
321314002964	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
321314002965	ATP binding site [chemical binding]; other site
321314002966	substrate interface [chemical binding]; other site
321314002967	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
321314002968	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
321314002969	dimer interface [polypeptide binding]; other site
321314002970	putative functional site; other site
321314002971	putative MPT binding site; other site
321314002972	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
321314002973	catalytic nucleophile [active]
321314002974	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
321314002975	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314002976	Walker A/P-loop; other site
321314002977	ATP binding site [chemical binding]; other site
321314002978	Q-loop/lid; other site
321314002979	ABC transporter signature motif; other site
321314002980	Walker B; other site
321314002981	D-loop; other site
321314002982	H-loop/switch region; other site
321314002983	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
321314002984	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314002985	Walker A/P-loop; other site
321314002986	ATP binding site [chemical binding]; other site
321314002987	Q-loop/lid; other site
321314002988	ABC transporter signature motif; other site
321314002989	Walker B; other site
321314002990	D-loop; other site
321314002991	H-loop/switch region; other site
321314002992	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
321314002993	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
321314002994	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
321314002995	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
321314002996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314002997	dimer interface [polypeptide binding]; other site
321314002998	conserved gate region; other site
321314002999	putative PBP binding loops; other site
321314003000	ABC-ATPase subunit interface; other site
321314003001	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
321314003002	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
321314003003	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314003004	dimer interface [polypeptide binding]; other site
321314003005	conserved gate region; other site
321314003006	putative PBP binding loops; other site
321314003007	ABC-ATPase subunit interface; other site
321314003008	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
321314003009	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
321314003010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314003011	FeS/SAM binding site; other site
321314003012	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
321314003013	Ligand binding site [chemical binding]; other site
321314003014	Electron transfer flavoprotein domain; Region: ETF; pfam01012
321314003015	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
321314003016	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
321314003017	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
321314003018	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
321314003019	active site
321314003020	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
321314003021	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
321314003022	active site
321314003023	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
321314003024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314003025	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
321314003026	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
321314003027	similar to Tn10
321314003028	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
321314003029	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314003030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314003031	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
321314003032	putative dimerization interface [polypeptide binding]; other site
321314003033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
321314003034	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
321314003035	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
321314003036	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
321314003037	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
321314003038	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
321314003039	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
321314003040	putative C-terminal domain interface [polypeptide binding]; other site
321314003041	putative GSH binding site (G-site) [chemical binding]; other site
321314003042	putative dimer interface [polypeptide binding]; other site
321314003043	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
321314003044	putative N-terminal domain interface [polypeptide binding]; other site
321314003045	putative dimer interface [polypeptide binding]; other site
321314003046	putative substrate binding pocket (H-site) [chemical binding]; other site
321314003047	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
321314003048	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
321314003049	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
321314003050	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
321314003051	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
321314003052	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314003053	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
321314003054	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
321314003055	active site
321314003056	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
321314003057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314003058	putative substrate translocation pore; other site
321314003059	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
321314003060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314003061	active site
321314003062	motif I; other site
321314003063	motif II; other site
321314003064	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314003065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314003066	putative substrate translocation pore; other site
321314003067	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314003068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
321314003069	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314003070	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
321314003071	putative transporter; Provisional; Region: PRK04972
321314003072	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
321314003073	TrkA-C domain; Region: TrkA_C; pfam02080
321314003074	TrkA-C domain; Region: TrkA_C; pfam02080
321314003075	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
321314003076	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
321314003077	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
321314003078	GSH binding site [chemical binding]; other site
321314003079	catalytic residues [active]
321314003080	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
321314003081	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
321314003082	RimK-like ATP-grasp domain; Region: RimK; pfam08443
321314003083	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
321314003084	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
321314003085	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
321314003086	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
321314003087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314003088	Walker A/P-loop; other site
321314003089	ATP binding site [chemical binding]; other site
321314003090	Q-loop/lid; other site
321314003091	ABC transporter signature motif; other site
321314003092	Walker B; other site
321314003093	D-loop; other site
321314003094	H-loop/switch region; other site
321314003095	TOBE domain; Region: TOBE_2; pfam08402
321314003096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314003097	dimer interface [polypeptide binding]; other site
321314003098	conserved gate region; other site
321314003099	putative PBP binding loops; other site
321314003100	ABC-ATPase subunit interface; other site
321314003101	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
321314003102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314003103	dimer interface [polypeptide binding]; other site
321314003104	conserved gate region; other site
321314003105	putative PBP binding loops; other site
321314003106	ABC-ATPase subunit interface; other site
321314003107	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
321314003108	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
321314003109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314003110	S-adenosylmethionine binding site [chemical binding]; other site
321314003111	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
321314003112	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
321314003113	active site
321314003114	P-loop; other site
321314003115	phosphorylation site [posttranslational modification]
321314003116	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
321314003117	Sulfatase; Region: Sulfatase; cl17466
321314003118	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
321314003119	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314003120	substrate binding pocket [chemical binding]; other site
321314003121	membrane-bound complex binding site; other site
321314003122	hinge residues; other site
321314003123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314003124	dimer interface [polypeptide binding]; other site
321314003125	conserved gate region; other site
321314003126	putative PBP binding loops; other site
321314003127	ABC-ATPase subunit interface; other site
321314003128	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314003129	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314003130	dimer interface [polypeptide binding]; other site
321314003131	conserved gate region; other site
321314003132	putative PBP binding loops; other site
321314003133	ABC-ATPase subunit interface; other site
321314003134	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
321314003135	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314003136	substrate binding pocket [chemical binding]; other site
321314003137	membrane-bound complex binding site; other site
321314003138	hinge residues; other site
321314003139	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
321314003140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314003141	Walker A/P-loop; other site
321314003142	ATP binding site [chemical binding]; other site
321314003143	Q-loop/lid; other site
321314003144	ABC transporter signature motif; other site
321314003145	Walker B; other site
321314003146	D-loop; other site
321314003147	H-loop/switch region; other site
321314003148	putative lipoprotein; Provisional; Region: PRK10533
321314003149	hypothetical protein; Provisional; Region: PRK02877
321314003150	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
321314003151	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
321314003152	amidase catalytic site [active]
321314003153	Zn binding residues [ion binding]; other site
321314003154	substrate binding site [chemical binding]; other site
321314003155	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
321314003156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
321314003157	NAD(P) binding site [chemical binding]; other site
321314003158	active site
321314003159	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
321314003160	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
321314003161	putative NAD(P) binding site [chemical binding]; other site
321314003162	putative active site [active]
321314003163	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
321314003164	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
321314003165	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
321314003166	tetramer interface [polypeptide binding]; other site
321314003167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314003168	catalytic residue [active]
321314003169	pyruvate dehydrogenase; Provisional; Region: PRK09124
321314003170	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
321314003171	PYR/PP interface [polypeptide binding]; other site
321314003172	dimer interface [polypeptide binding]; other site
321314003173	tetramer interface [polypeptide binding]; other site
321314003174	TPP binding site [chemical binding]; other site
321314003175	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
321314003176	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
321314003177	TPP-binding site [chemical binding]; other site
321314003178	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
321314003179	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
321314003180	FAD binding pocket [chemical binding]; other site
321314003181	FAD binding motif [chemical binding]; other site
321314003182	phosphate binding motif [ion binding]; other site
321314003183	beta-alpha-beta structure motif; other site
321314003184	NAD binding pocket [chemical binding]; other site
321314003185	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
321314003186	catalytic loop [active]
321314003187	iron binding site [ion binding]; other site
321314003188	hybrid cluster protein; Provisional; Region: PRK05290
321314003189	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
321314003190	ACS interaction site; other site
321314003191	CODH interaction site; other site
321314003192	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
321314003193	hybrid metal cluster; other site
321314003194	Predicted membrane protein [Function unknown]; Region: COG2431
321314003195	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
321314003196	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
321314003197	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
321314003198	putative active site [active]
321314003199	putative metal-binding site [ion binding]; other site
321314003200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
321314003201	macrolide transporter subunit MacA; Provisional; Region: PRK11578
321314003202	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314003203	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314003204	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
321314003205	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
321314003206	Walker A/P-loop; other site
321314003207	ATP binding site [chemical binding]; other site
321314003208	Q-loop/lid; other site
321314003209	ABC transporter signature motif; other site
321314003210	Walker B; other site
321314003211	D-loop; other site
321314003212	H-loop/switch region; other site
321314003213	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
321314003214	FtsX-like permease family; Region: FtsX; pfam02687
321314003215	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
321314003216	DNA-binding site [nucleotide binding]; DNA binding site
321314003217	RNA-binding motif; other site
321314003218	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
321314003219	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
321314003220	Clp amino terminal domain; Region: Clp_N; pfam02861
321314003221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314003222	Walker A motif; other site
321314003223	ATP binding site [chemical binding]; other site
321314003224	Walker B motif; other site
321314003225	arginine finger; other site
321314003226	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314003227	Walker A motif; other site
321314003228	ATP binding site [chemical binding]; other site
321314003229	Walker B motif; other site
321314003230	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
321314003231	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
321314003232	DNA binding site [nucleotide binding]
321314003233	active site
321314003234	Int/Topo IB signature motif; other site
321314003235	Isochorismatase family; Region: Isochorismatase; pfam00857
321314003236	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
321314003237	catalytic triad [active]
321314003238	dimer interface [polypeptide binding]; other site
321314003239	conserved cis-peptide bond; other site
321314003240	Pirin-related protein [General function prediction only]; Region: COG1741
321314003241	Pirin; Region: Pirin; pfam02678
321314003242	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
321314003243	LysR family transcriptional regulator; Provisional; Region: PRK14997
321314003244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314003245	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
321314003246	putative effector binding pocket; other site
321314003247	putative dimerization interface [polypeptide binding]; other site
321314003248	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
321314003249	rRNA binding site [nucleotide binding]; other site
321314003250	predicted 30S ribosome binding site; other site
321314003251	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
321314003252	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
321314003253	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314003254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314003255	Walker A/P-loop; other site
321314003256	ATP binding site [chemical binding]; other site
321314003257	Q-loop/lid; other site
321314003258	ABC transporter signature motif; other site
321314003259	Walker B; other site
321314003260	D-loop; other site
321314003261	H-loop/switch region; other site
321314003262	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
321314003263	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314003264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314003265	Walker A/P-loop; other site
321314003266	ATP binding site [chemical binding]; other site
321314003267	Q-loop/lid; other site
321314003268	ABC transporter signature motif; other site
321314003269	Walker B; other site
321314003270	D-loop; other site
321314003271	H-loop/switch region; other site
321314003272	thioredoxin reductase; Provisional; Region: PRK10262
321314003273	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314003274	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314003275	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
321314003276	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314003277	putative DNA binding site [nucleotide binding]; other site
321314003278	putative Zn2+ binding site [ion binding]; other site
321314003279	AsnC family; Region: AsnC_trans_reg; pfam01037
321314003280	DNA translocase FtsK; Provisional; Region: PRK10263
321314003281	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
321314003282	DNA translocase FtsK; Provisional; Region: PRK10263
321314003283	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
321314003284	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
321314003285	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
321314003286	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
321314003287	recombination factor protein RarA; Reviewed; Region: PRK13342
321314003288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314003289	Walker A motif; other site
321314003290	ATP binding site [chemical binding]; other site
321314003291	Walker B motif; other site
321314003292	arginine finger; other site
321314003293	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
321314003294	seryl-tRNA synthetase; Provisional; Region: PRK05431
321314003295	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
321314003296	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
321314003297	dimer interface [polypeptide binding]; other site
321314003298	active site
321314003299	motif 1; other site
321314003300	motif 2; other site
321314003301	motif 3; other site
321314003302	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
321314003303	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
321314003304	putative [Fe4-S4] binding site [ion binding]; other site
321314003305	putative molybdopterin cofactor binding site [chemical binding]; other site
321314003306	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
321314003307	putative molybdopterin cofactor binding site; other site
321314003308	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
321314003309	4Fe-4S binding domain; Region: Fer4; pfam00037
321314003310	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
321314003311	putative MFS family transporter protein; Provisional; Region: PRK03633
321314003312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314003313	putative substrate translocation pore; other site
321314003314	inner membrane transporter YjeM; Provisional; Region: PRK15238
321314003315	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
321314003316	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314003317	FeS/SAM binding site; other site
321314003318	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
321314003319	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
321314003320	Pyruvate formate lyase 1; Region: PFL1; cd01678
321314003321	coenzyme A binding site [chemical binding]; other site
321314003322	active site
321314003323	catalytic residues [active]
321314003324	glycine loop; other site
321314003325	formate transporter; Provisional; Region: PRK10805
321314003326	uncharacterized domain; Region: TIGR00702
321314003327	YcaO-like family; Region: YcaO; pfam02624
321314003328	Predicted membrane protein [Function unknown]; Region: COG2323
321314003329	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
321314003330	homodimer interface [polypeptide binding]; other site
321314003331	substrate-cofactor binding pocket; other site
321314003332	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314003333	catalytic residue [active]
321314003334	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
321314003335	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
321314003336	hinge; other site
321314003337	active site
321314003338	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
321314003339	cytidylate kinase; Provisional; Region: cmk; PRK00023
321314003340	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
321314003341	CMP-binding site; other site
321314003342	The sites determining sugar specificity; other site
321314003343	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
321314003344	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
321314003345	RNA binding site [nucleotide binding]; other site
321314003346	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
321314003347	RNA binding site [nucleotide binding]; other site
321314003348	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
321314003349	RNA binding site [nucleotide binding]; other site
321314003350	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
321314003351	RNA binding site [nucleotide binding]; other site
321314003352	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
321314003353	RNA binding site [nucleotide binding]; other site
321314003354	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
321314003355	IHF dimer interface [polypeptide binding]; other site
321314003356	IHF - DNA interface [nucleotide binding]; other site
321314003357	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314003358	Integrase core domain; Region: rve; pfam00665
321314003359	Integrase core domain; Region: rve_3; pfam13683
321314003360	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
321314003361	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314003362	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
321314003363	Walker A/P-loop; other site
321314003364	ATP binding site [chemical binding]; other site
321314003365	Q-loop/lid; other site
321314003366	ABC transporter signature motif; other site
321314003367	Walker B; other site
321314003368	D-loop; other site
321314003369	H-loop/switch region; other site
321314003370	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
321314003371	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
321314003372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
321314003373	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
321314003374	hypothetical protein; Provisional; Region: PRK11827
321314003375	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
321314003376	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
321314003377	Ligand binding site; other site
321314003378	oligomer interface; other site
321314003379	hypothetical protein; Provisional; Region: PRK10593
321314003380	Uncharacterized conserved protein [Function unknown]; Region: COG1434
321314003381	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
321314003382	putative active site [active]
321314003383	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
321314003384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314003385	S-adenosylmethionine binding site [chemical binding]; other site
321314003386	condesin subunit F; Provisional; Region: PRK05260
321314003387	condesin subunit E; Provisional; Region: PRK05256
321314003388	murein L,D-transpeptidase; Provisional; Region: PRK10594
321314003389	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
321314003390	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
321314003391	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
321314003392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
321314003393	Peptidase M15; Region: Peptidase_M15_3; cl01194
321314003394	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
321314003395	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
321314003396	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314003397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314003398	homodimer interface [polypeptide binding]; other site
321314003399	catalytic residue [active]
321314003400	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314003401	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
321314003402	trimer interface [polypeptide binding]; other site
321314003403	eyelet of channel; other site
321314003404	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
321314003405	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
321314003406	putative dimer interface [polypeptide binding]; other site
321314003407	putative anticodon binding site; other site
321314003408	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
321314003409	homodimer interface [polypeptide binding]; other site
321314003410	motif 1; other site
321314003411	motif 2; other site
321314003412	active site
321314003413	motif 3; other site
321314003414	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
321314003415	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314003416	putative DNA binding site [nucleotide binding]; other site
321314003417	putative Zn2+ binding site [ion binding]; other site
321314003418	AsnC family; Region: AsnC_trans_reg; pfam01037
321314003419	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
321314003420	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
321314003421	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314003422	catalytic residue [active]
321314003423	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
321314003424	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
321314003425	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
321314003426	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
321314003427	active site
321314003428	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
321314003429	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
321314003430	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
321314003431	Int/Topo IB signature motif; other site
321314003432	RecT family; Region: RecT; pfam03837
321314003433	exonuclease VIII; Reviewed; Region: PRK09709
321314003434	transcriptional repressor DicA; Reviewed; Region: PRK09706
321314003435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314003436	non-specific DNA binding site [nucleotide binding]; other site
321314003437	sequence-specific DNA binding site [nucleotide binding]; other site
321314003438	salt bridge; other site
321314003439	Bacteriophage CII protein; Region: Phage_CII; pfam05269
321314003440	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
321314003441	Replication protein P; Region: Phage_lambda_P; pfam06992
321314003442	DinI-like family; Region: DinI; pfam06183
321314003443	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
321314003444	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
321314003445	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
321314003446	PipA protein; Region: PipA; pfam07108
321314003447	phage holin, lambda family; Region: holin_lambda; TIGR01594
321314003448	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
321314003449	catalytic residues [active]
321314003450	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
321314003451	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
321314003452	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
321314003453	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
321314003454	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
321314003455	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
321314003456	Minor tail protein T; Region: Phage_tail_T; cl05636
321314003457	Phage-related minor tail protein [Function unknown]; Region: COG5281
321314003458	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
321314003459	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
321314003460	Phage-related protein [Function unknown]; Region: COG4718
321314003461	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
321314003462	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
321314003463	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
321314003464	E-class dimer interface [polypeptide binding]; other site
321314003465	P-class dimer interface [polypeptide binding]; other site
321314003466	active site
321314003467	Cu2+ binding site [ion binding]; other site
321314003468	Zn2+ binding site [ion binding]; other site
321314003469	Phage-related protein [Function unknown]; Region: gp18; COG4672
321314003470	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
321314003471	MPN+ (JAMM) motif; other site
321314003472	Zinc-binding site [ion binding]; other site
321314003473	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
321314003474	NlpC/P60 family; Region: NLPC_P60; cl17555
321314003475	Phage-related protein, tail component [Function unknown]; Region: COG4723
321314003476	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
321314003477	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
321314003478	Phage Tail Collar Domain; Region: Collar; pfam07484
321314003479	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
321314003480	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
321314003481	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
321314003482	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
321314003483	hypothetical protein; Provisional; Region: PRK09951
321314003484	DinI-like family; Region: DinI; cl11630
321314003485	aminopeptidase N; Provisional; Region: pepN; PRK14015
321314003486	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
321314003487	active site
321314003488	Zn binding site [ion binding]; other site
321314003489	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
321314003490	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
321314003491	quinone interaction residues [chemical binding]; other site
321314003492	active site
321314003493	catalytic residues [active]
321314003494	FMN binding site [chemical binding]; other site
321314003495	substrate binding site [chemical binding]; other site
321314003496	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
321314003497	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
321314003498	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
321314003499	MOSC domain; Region: MOSC; pfam03473
321314003500	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
321314003501	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
321314003502	catalytic loop [active]
321314003503	iron binding site [ion binding]; other site
321314003504	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
321314003505	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
321314003506	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
321314003507	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314003508	S-adenosylmethionine binding site [chemical binding]; other site
321314003509	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
321314003510	Paraquat-inducible protein A; Region: PqiA; pfam04403
321314003511	Paraquat-inducible protein A; Region: PqiA; pfam04403
321314003512	paraquat-inducible protein B; Provisional; Region: PRK10807
321314003513	mce related protein; Region: MCE; pfam02470
321314003514	mce related protein; Region: MCE; pfam02470
321314003515	mce related protein; Region: MCE; pfam02470
321314003516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
321314003517	Protein of unknown function (DUF330); Region: DUF330; pfam03886
321314003518	ribosome modulation factor; Provisional; Region: PRK14563
321314003519	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
321314003520	active site 1 [active]
321314003521	dimer interface [polypeptide binding]; other site
321314003522	active site 2 [active]
321314003523	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
321314003524	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
321314003525	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
321314003526	outer membrane protein A; Reviewed; Region: PRK10808
321314003527	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
321314003528	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
321314003529	ligand binding site [chemical binding]; other site
321314003530	cell division inhibitor SulA; Region: sula; TIGR00623
321314003531	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
321314003532	TfoX C-terminal domain; Region: TfoX_C; pfam04994
321314003533	TIGR01666 family membrane protein; Region: YCCS
321314003534	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
321314003535	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
321314003536	Predicted membrane protein [Function unknown]; Region: COG3304
321314003537	Domain of unknown function (DUF307); Region: DUF307; pfam03733
321314003538	Domain of unknown function (DUF307); Region: DUF307; pfam03733
321314003539	DNA helicase IV; Provisional; Region: helD; PRK11054
321314003540	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
321314003541	Part of AAA domain; Region: AAA_19; pfam13245
321314003542	Family description; Region: UvrD_C_2; pfam13538
321314003543	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
321314003544	active site
321314003545	dimer interfaces [polypeptide binding]; other site
321314003546	catalytic residues [active]
321314003547	hypothetical protein; Provisional; Region: PRK03641
321314003548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
321314003549	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
321314003550	heat shock protein HspQ; Provisional; Region: PRK14129
321314003551	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
321314003552	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
321314003553	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
321314003554	putative RNA binding site [nucleotide binding]; other site
321314003555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314003556	S-adenosylmethionine binding site [chemical binding]; other site
321314003557	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
321314003558	substrate binding site [chemical binding]; other site
321314003559	Cupin domain; Region: Cupin_2; cl17218
321314003560	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314003561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314003562	acylphosphatase; Provisional; Region: PRK14426
321314003563	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
321314003564	sulfur transfer protein TusE; Provisional; Region: PRK11508
321314003565	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
321314003566	YccA-like proteins; Region: YccA_like; cd10433
321314003567	PipA protein; Region: PipA; pfam07108
321314003568	secreted effector protein PipB; Provisional; Region: PRK15197
321314003569	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314003570	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314003571	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314003572	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
321314003573	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
321314003574	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
321314003575	Peptidase family C69; Region: Peptidase_C69; cl17793
321314003576	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
321314003577	HAMP domain; Region: HAMP; pfam00672
321314003578	dimerization interface [polypeptide binding]; other site
321314003579	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314003580	dimer interface [polypeptide binding]; other site
321314003581	phosphorylation site [posttranslational modification]
321314003582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314003583	ATP binding site [chemical binding]; other site
321314003584	Mg2+ binding site [ion binding]; other site
321314003585	G-X-G motif; other site
321314003586	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
321314003587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314003588	active site
321314003589	phosphorylation site [posttranslational modification]
321314003590	intermolecular recognition site; other site
321314003591	dimerization interface [polypeptide binding]; other site
321314003592	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314003593	DNA binding site [nucleotide binding]
321314003594	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
321314003595	active site
321314003596	homotetramer interface [polypeptide binding]; other site
321314003597	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
321314003598	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
321314003599	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
321314003600	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
321314003601	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
321314003602	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
321314003603	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
321314003604	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
321314003605	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
321314003606	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
321314003607	NAD binding site [chemical binding]; other site
321314003608	catalytic residues [active]
321314003609	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
321314003610	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
321314003611	putative active site [active]
321314003612	putative metal binding site [ion binding]; other site
321314003613	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
321314003614	putative substrate binding pocket [chemical binding]; other site
321314003615	trimer interface [polypeptide binding]; other site
321314003616	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
321314003617	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
321314003618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314003619	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
321314003620	putative substrate translocation pore; other site
321314003621	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
321314003622	Cupin domain; Region: Cupin_2; pfam07883
321314003623	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314003624	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
321314003625	anti-adapter protein IraM; Provisional; Region: PRK09919
321314003626	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
321314003627	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
321314003628	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
321314003629	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
321314003630	HSP70 interaction site [polypeptide binding]; other site
321314003631	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
321314003632	substrate binding site [polypeptide binding]; other site
321314003633	dimer interface [polypeptide binding]; other site
321314003634	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
321314003635	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
321314003636	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
321314003637	catalytic residues [active]
321314003638	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
321314003639	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
321314003640	catalytic residues [active]
321314003641	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
321314003642	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
321314003643	catalytic core [active]
321314003644	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
321314003645	hypothetical protein; Provisional; Region: PRK10174
321314003646	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
321314003647	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
321314003648	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314003649	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
321314003650	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
321314003651	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
321314003652	Predicted transcriptional regulator [Transcription]; Region: COG3905
321314003653	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
321314003654	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
321314003655	Glutamate binding site [chemical binding]; other site
321314003656	NAD binding site [chemical binding]; other site
321314003657	catalytic residues [active]
321314003658	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
321314003659	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
321314003660	Na binding site [ion binding]; other site
321314003661	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
321314003662	hypothetical protein; Provisional; Region: PRK10536
321314003663	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
321314003664	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
321314003665	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
321314003666	putative active site [active]
321314003667	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
321314003668	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
321314003669	putative active site cavity [active]
321314003670	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
321314003671	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
321314003672	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
321314003673	similar to Tn10
321314003674	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
321314003675	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
321314003676	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
321314003677	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
321314003678	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
321314003679	putative ligand binding site [chemical binding]; other site
321314003680	NAD binding site [chemical binding]; other site
321314003681	dimerization interface [polypeptide binding]; other site
321314003682	catalytic site [active]
321314003683	putative hydrolase; Validated; Region: PRK09248
321314003684	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
321314003685	active site
321314003686	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
321314003687	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
321314003688	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
321314003689	curli assembly protein CsgF; Provisional; Region: PRK10050
321314003690	curli assembly protein CsgE; Provisional; Region: PRK10386
321314003691	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
321314003692	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314003693	DNA binding residues [nucleotide binding]
321314003694	dimerization interface [polypeptide binding]; other site
321314003695	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
321314003696	Curlin associated repeat; Region: Curlin_rpt; pfam07012
321314003697	Curlin associated repeat; Region: Curlin_rpt; pfam07012
321314003698	major curlin subunit; Provisional; Region: csgA; PRK10051
321314003699	Curlin associated repeat; Region: Curlin_rpt; pfam07012
321314003700	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
321314003701	Fimbrial protein; Region: Fimbrial; cl01416
321314003702	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
321314003703	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
321314003704	putative active site [active]
321314003705	catalytic site [active]
321314003706	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
321314003707	putative active site [active]
321314003708	catalytic site [active]
321314003709	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
321314003710	Acyltransferase family; Region: Acyl_transf_3; pfam01757
321314003711	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
321314003712	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
321314003713	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
321314003714	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
321314003715	Ligand binding site; other site
321314003716	DXD motif; other site
321314003717	lipoprotein; Provisional; Region: PRK10175
321314003718	secY/secA suppressor protein; Provisional; Region: PRK11467
321314003719	drug efflux system protein MdtG; Provisional; Region: PRK09874
321314003720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314003721	putative substrate translocation pore; other site
321314003722	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
321314003723	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
321314003724	putative acyl-acceptor binding pocket; other site
321314003725	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
321314003726	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
321314003727	active site residue [active]
321314003728	hypothetical protein; Provisional; Region: PRK03757
321314003729	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
321314003730	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
321314003731	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
321314003732	hydroxyglutarate oxidase; Provisional; Region: PRK11728
321314003733	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
321314003734	DNA damage-inducible protein I; Provisional; Region: PRK10597
321314003735	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
321314003736	active site
321314003737	substrate binding pocket [chemical binding]; other site
321314003738	dimer interface [polypeptide binding]; other site
321314003739	lipoprotein; Provisional; Region: PRK10598
321314003740	glutaredoxin 2; Provisional; Region: PRK10387
321314003741	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
321314003742	C-terminal domain interface [polypeptide binding]; other site
321314003743	GSH binding site (G-site) [chemical binding]; other site
321314003744	catalytic residues [active]
321314003745	putative dimer interface [polypeptide binding]; other site
321314003746	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
321314003747	N-terminal domain interface [polypeptide binding]; other site
321314003748	multidrug resistance protein MdtH; Provisional; Region: PRK11646
321314003749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314003750	putative substrate translocation pore; other site
321314003751	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
321314003752	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
321314003753	hypothetical protein; Provisional; Region: PRK11239
321314003754	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
321314003755	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
321314003756	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
321314003757	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
321314003758	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
321314003759	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
321314003760	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
321314003761	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
321314003762	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
321314003763	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
321314003764	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
321314003765	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
321314003766	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
321314003767	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
321314003768	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
321314003769	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
321314003770	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
321314003771	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
321314003772	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
321314003773	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
321314003774	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
321314003775	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
321314003776	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
321314003777	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
321314003778	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
321314003779	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
321314003780	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
321314003781	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
321314003782	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
321314003783	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
321314003784	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
321314003785	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
321314003786	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
321314003787	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
321314003788	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
321314003789	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
321314003790	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
321314003791	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
321314003792	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
321314003793	homodimer interface [polypeptide binding]; other site
321314003794	oligonucleotide binding site [chemical binding]; other site
321314003795	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
321314003796	Protein of unknown function (DUF2655); Region: DUF2655; pfam10848
321314003797	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
321314003798	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314003799	RNA binding surface [nucleotide binding]; other site
321314003800	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
321314003801	active site
321314003802	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
321314003803	Maf-like protein; Region: Maf; pfam02545
321314003804	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
321314003805	active site
321314003806	dimer interface [polypeptide binding]; other site
321314003807	hypothetical protein; Provisional; Region: PRK11193
321314003808	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
321314003809	putative phosphate acyltransferase; Provisional; Region: PRK05331
321314003810	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
321314003811	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
321314003812	dimer interface [polypeptide binding]; other site
321314003813	active site
321314003814	CoA binding pocket [chemical binding]; other site
321314003815	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
321314003816	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
321314003817	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
321314003818	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
321314003819	NAD(P) binding site [chemical binding]; other site
321314003820	homotetramer interface [polypeptide binding]; other site
321314003821	homodimer interface [polypeptide binding]; other site
321314003822	active site
321314003823	acyl carrier protein; Provisional; Region: acpP; PRK00982
321314003824	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
321314003825	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
321314003826	dimer interface [polypeptide binding]; other site
321314003827	active site
321314003828	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314003829	Integrase core domain; Region: rve; pfam00665
321314003830	Integrase core domain; Region: rve_3; pfam13683
321314003831	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
321314003832	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
321314003833	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314003834	catalytic residue [active]
321314003835	conserved hypothetical protein, YceG family; Region: TIGR00247
321314003836	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
321314003837	dimerization interface [polypeptide binding]; other site
321314003838	thymidylate kinase; Validated; Region: tmk; PRK00698
321314003839	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
321314003840	TMP-binding site; other site
321314003841	ATP-binding site [chemical binding]; other site
321314003842	DNA polymerase III subunit delta'; Validated; Region: PRK07993
321314003843	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
321314003844	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
321314003845	active site
321314003846	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
321314003847	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
321314003848	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
321314003849	active site turn [active]
321314003850	phosphorylation site [posttranslational modification]
321314003851	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
321314003852	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314003853	N-terminal plug; other site
321314003854	ligand-binding site [chemical binding]; other site
321314003855	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
321314003856	nucleotide binding site/active site [active]
321314003857	HIT family signature motif; other site
321314003858	catalytic residue [active]
321314003859	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
321314003860	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
321314003861	putative dimer interface [polypeptide binding]; other site
321314003862	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
321314003863	thiamine kinase; Region: ycfN_thiK; TIGR02721
321314003864	thiamine kinase; Provisional; Region: thiK; PRK10271
321314003865	substrate binding site [chemical binding]; other site
321314003866	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
321314003867	beta-hexosaminidase; Provisional; Region: PRK05337
321314003868	hypothetical protein; Provisional; Region: PRK04940
321314003869	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
321314003870	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314003871	hypothetical protein; Provisional; Region: PRK11280
321314003872	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
321314003873	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314003874	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314003875	L,D-transpeptidase; Provisional; Region: PRK10190
321314003876	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314003877	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
321314003878	transcription-repair coupling factor; Provisional; Region: PRK10689
321314003879	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
321314003880	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314003881	ATP binding site [chemical binding]; other site
321314003882	putative Mg++ binding site [ion binding]; other site
321314003883	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314003884	nucleotide binding region [chemical binding]; other site
321314003885	ATP-binding site [chemical binding]; other site
321314003886	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
321314003887	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
321314003888	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
321314003889	FtsX-like permease family; Region: FtsX; pfam02687
321314003890	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
321314003891	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
321314003892	Walker A/P-loop; other site
321314003893	ATP binding site [chemical binding]; other site
321314003894	Q-loop/lid; other site
321314003895	ABC transporter signature motif; other site
321314003896	Walker B; other site
321314003897	D-loop; other site
321314003898	H-loop/switch region; other site
321314003899	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
321314003900	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
321314003901	FtsX-like permease family; Region: FtsX; pfam02687
321314003902	fructokinase; Reviewed; Region: PRK09557
321314003903	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314003904	nucleotide binding site [chemical binding]; other site
321314003905	NAD-dependent deacetylase; Provisional; Region: PRK00481
321314003906	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
321314003907	NAD+ binding site [chemical binding]; other site
321314003908	substrate binding site [chemical binding]; other site
321314003909	Zn binding site [ion binding]; other site
321314003910	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
321314003911	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
321314003912	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
321314003913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314003914	dimer interface [polypeptide binding]; other site
321314003915	conserved gate region; other site
321314003916	putative PBP binding loops; other site
321314003917	ABC-ATPase subunit interface; other site
321314003918	Sif protein; Region: Sif; pfam06767
321314003919	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
321314003920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314003921	dimer interface [polypeptide binding]; other site
321314003922	conserved gate region; other site
321314003923	putative PBP binding loops; other site
321314003924	ABC-ATPase subunit interface; other site
321314003925	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
321314003926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314003927	Walker A/P-loop; other site
321314003928	ATP binding site [chemical binding]; other site
321314003929	Q-loop/lid; other site
321314003930	ABC transporter signature motif; other site
321314003931	Walker B; other site
321314003932	D-loop; other site
321314003933	H-loop/switch region; other site
321314003934	TOBE domain; Region: TOBE_2; pfam08402
321314003935	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
321314003936	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
321314003937	metal binding site [ion binding]; metal-binding site
321314003938	dimer interface [polypeptide binding]; other site
321314003939	Uncharacterized conserved protein [Function unknown]; Region: COG2850
321314003940	Cupin-like domain; Region: Cupin_8; pfam13621
321314003941	sensor protein PhoQ; Provisional; Region: PRK10815
321314003942	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
321314003943	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
321314003944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314003945	ATP binding site [chemical binding]; other site
321314003946	Mg2+ binding site [ion binding]; other site
321314003947	G-X-G motif; other site
321314003948	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
321314003949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314003950	active site
321314003951	phosphorylation site [posttranslational modification]
321314003952	intermolecular recognition site; other site
321314003953	dimerization interface [polypeptide binding]; other site
321314003954	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314003955	DNA binding site [nucleotide binding]
321314003956	adenylosuccinate lyase; Provisional; Region: PRK09285
321314003957	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
321314003958	tetramer interface [polypeptide binding]; other site
321314003959	active site
321314003960	putative lysogenization regulator; Reviewed; Region: PRK00218
321314003961	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
321314003962	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
321314003963	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
321314003964	nudix motif; other site
321314003965	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
321314003966	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
321314003967	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
321314003968	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
321314003969	active site
321314003970	isocitrate dehydrogenase; Validated; Region: PRK07362
321314003971	isocitrate dehydrogenase; Reviewed; Region: PRK07006
321314003972	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
321314003973	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
321314003974	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
321314003975	dimer interface [polypeptide binding]; other site
321314003976	active site
321314003977	Int/Topo IB signature motif; other site
321314003978	similar to Tn10
321314003979	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
321314003980	Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065
321314003981	Predicted transcriptional regulator [Transcription]; Region: COG2932
321314003982	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314003983	non-specific DNA binding site [nucleotide binding]; other site
321314003984	salt bridge; other site
321314003985	sequence-specific DNA binding site [nucleotide binding]; other site
321314003986	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
321314003987	Catalytic site [active]
321314003988	Ash protein family; Region: Phage_ASH; pfam10554
321314003989	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
321314003990	Ash protein family; Region: Phage_ASH; pfam10554
321314003991	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
321314003992	Helix-turn-helix domain; Region: HTH_36; pfam13730
321314003993	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
321314003994	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
321314003995	KilA-N domain; Region: KilA-N; pfam04383
321314003996	Protein of unknown function (DUF968); Region: DUF968; pfam06147
321314003997	Protein of unknown function (DUF1133); Region: DUF1133; pfam06576
321314003998	DNA methylase; Region: N6_N4_Mtase; pfam01555
321314003999	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
321314004000	Protein of unknown function (DUF754); Region: DUF754; pfam05449
321314004001	Predicted chitinase [General function prediction only]; Region: COG3179
321314004002	catalytic residue [active]
321314004003	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
321314004004	Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471
321314004005	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
321314004006	gpW; Region: gpW; pfam02831
321314004007	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
321314004008	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
321314004009	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
321314004010	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
321314004011	tandem repeat interface [polypeptide binding]; other site
321314004012	oligomer interface [polypeptide binding]; other site
321314004013	active site residues [active]
321314004014	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
321314004015	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
321314004016	DNA packaging protein FI; Region: Packaging_FI; pfam14000
321314004017	Phage Head-Tail Attachment; Region: Phage_attach; pfam05354
321314004018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
321314004019	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
321314004020	Probable transposase; Region: OrfB_IS605; pfam01385
321314004021	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
321314004022	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
321314004023	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
321314004024	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
321314004025	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
321314004026	Phage tail protein; Region: Phage_tail_3; pfam08813
321314004027	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894
321314004028	Minor tail protein T; Region: Phage_tail_T; pfam06223
321314004029	Phage-related minor tail protein [Function unknown]; Region: COG5281
321314004030	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
321314004031	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
321314004032	Phage-related protein [Function unknown]; Region: COG4718
321314004033	Phage-related protein [Function unknown]; Region: gp18; COG4672
321314004034	Predicted metal-dependent protease of the PAD1/JAB1 superfamily [General function prediction only]; Region: COG1310
321314004035	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
321314004036	NlpC/P60 family; Region: NLPC_P60; cl17555
321314004037	Phage-related protein, tail component [Function unknown]; Region: COG4723
321314004038	Phage-related protein, tail component [Function unknown]; Region: COG4733
321314004039	Putative phage tail protein; Region: Phage-tail_3; pfam13550
321314004040	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
321314004041	Interdomain contacts; other site
321314004042	Cytokine receptor motif; other site
321314004043	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
321314004044	Fibronectin type III protein; Region: DUF3672; pfam12421
321314004045	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
321314004046	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
321314004047	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
321314004048	ParB-like nuclease domain; Region: ParB; smart00470
321314004049	BRO family, N-terminal domain; Region: Bro-N; smart01040
321314004050	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
321314004051	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
321314004052	peptide binding site [polypeptide binding]; other site
321314004053	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
321314004054	dimer interface [polypeptide binding]; other site
321314004055	catalytic triad [active]
321314004056	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
321314004057	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
321314004058	DinI-like family; Region: DinI; pfam06183
321314004059	Ricin-type beta-trefoil; Region: RICIN; smart00458
321314004060	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
321314004061	putative sugar binding sites [chemical binding]; other site
321314004062	Q-X-W motif; other site
321314004063	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
321314004064	DNA-binding site [nucleotide binding]; DNA binding site
321314004065	RNA-binding motif; other site
321314004066	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
321314004067	lysozyme inhibitor; Provisional; Region: PRK13791
321314004068	similar to protein in the LexA regulon
321314004069	similar to  periplasmic protein
321314004070	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
321314004071	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
321314004072	putative dimer interface [polypeptide binding]; other site
321314004073	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
321314004074	BNR repeat-like domain; Region: BNR_2; pfam13088
321314004075	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
321314004076	TRL-like protein family; Region: TRL; pfam13146
321314004077	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
321314004078	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
321314004079	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
321314004080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314004081	dimer interface [polypeptide binding]; other site
321314004082	conserved gate region; other site
321314004083	ABC-ATPase subunit interface; other site
321314004084	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
321314004085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314004086	dimer interface [polypeptide binding]; other site
321314004087	conserved gate region; other site
321314004088	putative PBP binding loops; other site
321314004089	ABC-ATPase subunit interface; other site
321314004090	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314004091	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
321314004092	Walker A/P-loop; other site
321314004093	ATP binding site [chemical binding]; other site
321314004094	Q-loop/lid; other site
321314004095	ABC transporter signature motif; other site
321314004096	Walker B; other site
321314004097	D-loop; other site
321314004098	H-loop/switch region; other site
321314004099	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314004100	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
321314004101	Walker A/P-loop; other site
321314004102	ATP binding site [chemical binding]; other site
321314004103	Q-loop/lid; other site
321314004104	ABC transporter signature motif; other site
321314004105	Walker B; other site
321314004106	D-loop; other site
321314004107	H-loop/switch region; other site
321314004108	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
321314004109	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314004110	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
321314004111	dimerization interface [polypeptide binding]; other site
321314004112	zinc/cadmium-binding protein; Provisional; Region: PRK10306
321314004113	aminoglycoside resistance protein; Provisional; Region: PRK13746
321314004114	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
321314004115	active site
321314004116	NTP binding site [chemical binding]; other site
321314004117	metal binding triad [ion binding]; metal-binding site
321314004118	antibiotic binding site [chemical binding]; other site
321314004119	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
321314004120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314004121	DNA binding residues [nucleotide binding]
321314004122	transcriptional regulator MirA; Provisional; Region: PRK15043
321314004123	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
321314004124	DNA binding residues [nucleotide binding]
321314004125	dimer interface [polypeptide binding]; other site
321314004126	Pleckstrin homology-like domain; Region: PH-like; cl17171
321314004127	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
321314004128	chorismate mutase; Provisional; Region: PRK08055
321314004129	leucine export protein LeuE; Provisional; Region: PRK10958
321314004130	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
321314004131	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
321314004132	hypothetical protein; Provisional; Region: PRK10457
321314004133	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
321314004134	murein hydrolase B; Provisional; Region: PRK10760; cl17906
321314004135	Domain of unknown function (DUF333); Region: DUF333; pfam03891
321314004136	Uncharacterized conserved protein [Function unknown]; Region: COG3189
321314004137	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
321314004138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004139	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314004140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314004141	Predicted membrane protein [Function unknown]; Region: COG2707
321314004142	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
321314004143	putative deacylase active site [active]
321314004144	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
321314004145	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314004146	metal binding site [ion binding]; metal-binding site
321314004147	active site
321314004148	I-site; other site
321314004149	hypothetical protein; Provisional; Region: PRK05325
321314004150	PrkA family serine protein kinase; Provisional; Region: PRK15455
321314004151	AAA ATPase domain; Region: AAA_16; pfam13191
321314004152	Walker A motif; other site
321314004153	ATP binding site [chemical binding]; other site
321314004154	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
321314004155	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
321314004156	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
321314004157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314004158	FeS/SAM binding site; other site
321314004159	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
321314004160	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314004161	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314004162	active site
321314004163	catalytic tetrad [active]
321314004164	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
321314004165	active site
321314004166	phosphate binding residues; other site
321314004167	catalytic residues [active]
321314004168	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
321314004169	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
321314004170	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
321314004171	methionine sulfoxide reductase B; Provisional; Region: PRK00222
321314004172	SelR domain; Region: SelR; pfam01641
321314004173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
321314004174	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
321314004175	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
321314004176	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
321314004177	putative NAD(P) binding site [chemical binding]; other site
321314004178	catalytic Zn binding site [ion binding]; other site
321314004179	structural Zn binding site [ion binding]; other site
321314004180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004182	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
321314004183	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
321314004184	inhibitor binding site; inhibition site
321314004185	catalytic Zn binding site [ion binding]; other site
321314004186	structural Zn binding site [ion binding]; other site
321314004187	NADP binding site [chemical binding]; other site
321314004188	tetramer interface [polypeptide binding]; other site
321314004189	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
321314004190	intersubunit interface [polypeptide binding]; other site
321314004191	active site
321314004192	zinc binding site [ion binding]; other site
321314004193	Na+ binding site [ion binding]; other site
321314004194	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
321314004195	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314004196	substrate binding site [chemical binding]; other site
321314004197	ATP binding site [chemical binding]; other site
321314004198	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314004199	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314004200	active site
321314004201	catalytic tetrad [active]
321314004202	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314004203	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
321314004204	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314004205	benzoate transport; Region: 2A0115; TIGR00895
321314004206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004207	putative substrate translocation pore; other site
321314004208	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004209	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
321314004210	Isochorismatase family; Region: Isochorismatase; pfam00857
321314004211	catalytic triad [active]
321314004212	metal binding site [ion binding]; metal-binding site
321314004213	conserved cis-peptide bond; other site
321314004214	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
321314004215	active site
321314004216	homodimer interface [polypeptide binding]; other site
321314004217	protease 4; Provisional; Region: PRK10949
321314004218	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
321314004219	tandem repeat interface [polypeptide binding]; other site
321314004220	oligomer interface [polypeptide binding]; other site
321314004221	active site residues [active]
321314004222	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
321314004223	tandem repeat interface [polypeptide binding]; other site
321314004224	oligomer interface [polypeptide binding]; other site
321314004225	active site residues [active]
321314004226	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
321314004227	putative FMN binding site [chemical binding]; other site
321314004228	selenophosphate synthetase; Provisional; Region: PRK00943
321314004229	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
321314004230	dimerization interface [polypeptide binding]; other site
321314004231	putative ATP binding site [chemical binding]; other site
321314004232	DNA topoisomerase III; Provisional; Region: PRK07726
321314004233	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
321314004234	active site
321314004235	putative interdomain interaction site [polypeptide binding]; other site
321314004236	putative metal-binding site [ion binding]; other site
321314004237	putative nucleotide binding site [chemical binding]; other site
321314004238	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
321314004239	domain I; other site
321314004240	DNA binding groove [nucleotide binding]
321314004241	phosphate binding site [ion binding]; other site
321314004242	domain II; other site
321314004243	domain III; other site
321314004244	nucleotide binding site [chemical binding]; other site
321314004245	catalytic site [active]
321314004246	domain IV; other site
321314004247	glutamate dehydrogenase; Provisional; Region: PRK09414
321314004248	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
321314004249	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
321314004250	NAD(P) binding site [chemical binding]; other site
321314004251	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
321314004252	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
321314004253	active site
321314004254	8-oxo-dGMP binding site [chemical binding]; other site
321314004255	nudix motif; other site
321314004256	metal binding site [ion binding]; metal-binding site
321314004257	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
321314004258	putative catalytic site [active]
321314004259	putative phosphate binding site [ion binding]; other site
321314004260	active site
321314004261	metal binding site A [ion binding]; metal-binding site
321314004262	DNA binding site [nucleotide binding]
321314004263	putative AP binding site [nucleotide binding]; other site
321314004264	putative metal binding site B [ion binding]; other site
321314004265	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
321314004266	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
321314004267	inhibitor-cofactor binding pocket; inhibition site
321314004268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314004269	catalytic residue [active]
321314004270	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
321314004271	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
321314004272	Succinylarginine dihydrolase; Region: AstB; cl01511
321314004273	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
321314004274	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
321314004275	putative active site [active]
321314004276	Zn binding site [ion binding]; other site
321314004277	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
321314004278	dimer interface [polypeptide binding]; other site
321314004279	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
321314004280	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
321314004281	GIY-YIG motif/motif A; other site
321314004282	active site
321314004283	catalytic site [active]
321314004284	putative DNA binding site [nucleotide binding]; other site
321314004285	metal binding site [ion binding]; metal-binding site
321314004286	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
321314004287	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
321314004288	homodimer interface [polypeptide binding]; other site
321314004289	NAD binding pocket [chemical binding]; other site
321314004290	ATP binding pocket [chemical binding]; other site
321314004291	Mg binding site [ion binding]; other site
321314004292	active-site loop [active]
321314004293	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
321314004294	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
321314004295	active site
321314004296	P-loop; other site
321314004297	phosphorylation site [posttranslational modification]
321314004298	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
321314004299	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
321314004300	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
321314004301	methionine cluster; other site
321314004302	active site
321314004303	phosphorylation site [posttranslational modification]
321314004304	metal binding site [ion binding]; metal-binding site
321314004305	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
321314004306	Cupin domain; Region: Cupin_2; pfam07883
321314004307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314004308	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
321314004309	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
321314004310	NAD binding site [chemical binding]; other site
321314004311	sugar binding site [chemical binding]; other site
321314004312	divalent metal binding site [ion binding]; other site
321314004313	tetramer (dimer of dimers) interface [polypeptide binding]; other site
321314004314	dimer interface [polypeptide binding]; other site
321314004315	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
321314004316	putative active site [active]
321314004317	YdjC motif; other site
321314004318	Mg binding site [ion binding]; other site
321314004319	putative homodimer interface [polypeptide binding]; other site
321314004320	hydroperoxidase II; Provisional; Region: katE; PRK11249
321314004321	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
321314004322	tetramer interface [polypeptide binding]; other site
321314004323	heme binding pocket [chemical binding]; other site
321314004324	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
321314004325	domain interactions; other site
321314004326	cell division modulator; Provisional; Region: PRK10113
321314004327	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
321314004328	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
321314004329	inner membrane protein; Provisional; Region: PRK11648
321314004330	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
321314004331	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
321314004332	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314004333	motif II; other site
321314004334	YniB-like protein; Region: YniB; pfam14002
321314004335	Phosphotransferase enzyme family; Region: APH; pfam01636
321314004336	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
321314004337	active site
321314004338	ATP binding site [chemical binding]; other site
321314004339	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
321314004340	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
321314004341	6-phosphofructokinase 2; Provisional; Region: PRK10294
321314004342	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
321314004343	putative substrate binding site [chemical binding]; other site
321314004344	putative ATP binding site [chemical binding]; other site
321314004345	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
321314004346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
321314004347	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
321314004348	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
321314004349	active site
321314004350	substrate binding site [chemical binding]; other site
321314004351	Mg2+ binding site [ion binding]; other site
321314004352	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
321314004353	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
321314004354	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
321314004355	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
321314004356	active site
321314004357	dimer interface [polypeptide binding]; other site
321314004358	motif 1; other site
321314004359	motif 2; other site
321314004360	motif 3; other site
321314004361	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
321314004362	anticodon binding site; other site
321314004363	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
321314004364	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
321314004365	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
321314004366	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
321314004367	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
321314004368	23S rRNA binding site [nucleotide binding]; other site
321314004369	L21 binding site [polypeptide binding]; other site
321314004370	L13 binding site [polypeptide binding]; other site
321314004371	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
321314004372	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
321314004373	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
321314004374	dimer interface [polypeptide binding]; other site
321314004375	motif 1; other site
321314004376	active site
321314004377	motif 2; other site
321314004378	motif 3; other site
321314004379	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
321314004380	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
321314004381	putative tRNA-binding site [nucleotide binding]; other site
321314004382	B3/4 domain; Region: B3_4; pfam03483
321314004383	tRNA synthetase B5 domain; Region: B5; smart00874
321314004384	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
321314004385	dimer interface [polypeptide binding]; other site
321314004386	motif 1; other site
321314004387	motif 3; other site
321314004388	motif 2; other site
321314004389	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
321314004390	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
321314004391	IHF dimer interface [polypeptide binding]; other site
321314004392	IHF - DNA interface [nucleotide binding]; other site
321314004393	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
321314004394	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314004395	ABC-ATPase subunit  interface; other site
321314004396	dimer interface [polypeptide binding]; other site
321314004397	putative PBP binding regions; other site
321314004398	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
321314004399	catalytic residues [active]
321314004400	dimer interface [polypeptide binding]; other site
321314004401	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
321314004402	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
321314004403	Walker A/P-loop; other site
321314004404	ATP binding site [chemical binding]; other site
321314004405	Q-loop/lid; other site
321314004406	ABC transporter signature motif; other site
321314004407	Walker B; other site
321314004408	D-loop; other site
321314004409	H-loop/switch region; other site
321314004410	NlpC/P60 family; Region: NLPC_P60; pfam00877
321314004411	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
321314004412	Uncharacterized conserved protein [Function unknown]; Region: COG0397
321314004413	hypothetical protein; Validated; Region: PRK00029
321314004414	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
321314004415	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
321314004416	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
321314004417	PEP synthetase regulatory protein; Provisional; Region: PRK05339
321314004418	phosphoenolpyruvate synthase; Validated; Region: PRK06464
321314004419	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
321314004420	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
321314004421	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
321314004422	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
321314004423	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
321314004424	acyl-activating enzyme (AAE) consensus motif; other site
321314004425	putative AMP binding site [chemical binding]; other site
321314004426	putative active site [active]
321314004427	putative CoA binding site [chemical binding]; other site
321314004428	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
321314004429	oxidoreductase; Provisional; Region: PRK10015
321314004430	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
321314004431	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
321314004432	Ligand binding site [chemical binding]; other site
321314004433	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
321314004434	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
321314004435	Ligand binding site [chemical binding]; other site
321314004436	Electron transfer flavoprotein domain; Region: ETF; pfam01012
321314004437	Cupin domain; Region: Cupin_2; pfam07883
321314004438	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314004439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314004440	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
321314004441	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
321314004442	active site
321314004443	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
321314004444	Coenzyme A transferase; Region: CoA_trans; smart00882
321314004445	Coenzyme A transferase; Region: CoA_trans; cl17247
321314004446	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
321314004447	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
321314004448	active site
321314004449	catalytic residue [active]
321314004450	dimer interface [polypeptide binding]; other site
321314004451	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
321314004452	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
321314004453	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
321314004454	shikimate binding site; other site
321314004455	NAD(P) binding site [chemical binding]; other site
321314004456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004457	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314004458	putative substrate translocation pore; other site
321314004459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004460	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314004461	putative substrate translocation pore; other site
321314004462	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
321314004463	Integrase core domain; Region: rve; pfam00665
321314004464	Integrase core domain; Region: rve_3; pfam13683
321314004465	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314004466	putative inner membrane protein; Provisional; Region: PRK10983
321314004467	Domain of unknown function DUF20; Region: UPF0118; pfam01594
321314004468	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
321314004469	FAD binding domain; Region: FAD_binding_4; pfam01565
321314004470	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
321314004471	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
321314004472	CoenzymeA binding site [chemical binding]; other site
321314004473	subunit interaction site [polypeptide binding]; other site
321314004474	PHB binding site; other site
321314004475	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
321314004476	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
321314004477	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
321314004478	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
321314004479	putative ABC transporter; Region: ycf24; CHL00085
321314004480	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
321314004481	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
321314004482	Walker A/P-loop; other site
321314004483	ATP binding site [chemical binding]; other site
321314004484	Q-loop/lid; other site
321314004485	ABC transporter signature motif; other site
321314004486	Walker B; other site
321314004487	D-loop; other site
321314004488	H-loop/switch region; other site
321314004489	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
321314004490	FeS assembly protein SufD; Region: sufD; TIGR01981
321314004491	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
321314004492	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
321314004493	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314004494	catalytic residue [active]
321314004495	cysteine desufuration protein SufE; Provisional; Region: PRK09296
321314004496	L,D-transpeptidase; Provisional; Region: PRK10190
321314004497	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314004498	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
321314004499	murein lipoprotein; Provisional; Region: PRK15396
321314004500	murein lipoprotein; Provisional; Region: PRK15396
321314004501	murein lipoprotein; Provisional; Region: PRK15396
321314004502	pyruvate kinase; Provisional; Region: PRK09206
321314004503	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
321314004504	domain interfaces; other site
321314004505	active site
321314004506	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
321314004507	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
321314004508	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
321314004509	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314004510	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
321314004511	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314004512	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
321314004513	substrate binding site [chemical binding]; other site
321314004514	dimer interface [polypeptide binding]; other site
321314004515	ATP binding site [chemical binding]; other site
321314004516	tetrathionate reductase subunit A; Provisional; Region: PRK14991
321314004517	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
321314004518	putative [Fe4-S4] binding site [ion binding]; other site
321314004519	putative molybdopterin cofactor binding site [chemical binding]; other site
321314004520	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
321314004521	putative molybdopterin cofactor binding site; other site
321314004522	tetrathionate reductase subunit C; Provisional; Region: PRK14992
321314004523	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
321314004524	tetrathionate reductase subunit B; Provisional; Region: PRK14993
321314004525	4Fe-4S binding domain; Region: Fer4; pfam00037
321314004526	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
321314004527	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
321314004528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
321314004529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314004530	dimer interface [polypeptide binding]; other site
321314004531	phosphorylation site [posttranslational modification]
321314004532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314004533	ATP binding site [chemical binding]; other site
321314004534	Mg2+ binding site [ion binding]; other site
321314004535	G-X-G motif; other site
321314004536	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
321314004537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314004538	active site
321314004539	phosphorylation site [posttranslational modification]
321314004540	intermolecular recognition site; other site
321314004541	dimerization interface [polypeptide binding]; other site
321314004542	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314004543	DNA binding residues [nucleotide binding]
321314004544	dimerization interface [polypeptide binding]; other site
321314004545	hypothetical protein; Provisional; Region: PRK10292
321314004546	Uncharacterized conserved protein [Function unknown]; Region: COG1683
321314004547	Uncharacterized conserved protein [Function unknown]; Region: COG3272
321314004548	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
321314004549	transcriptional regulator MirA; Provisional; Region: PRK15043
321314004550	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
321314004551	DNA binding residues [nucleotide binding]
321314004552	two component system sensor kinase SsrB; Provisional; Region: PRK15369
321314004553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314004554	active site
321314004555	phosphorylation site [posttranslational modification]
321314004556	intermolecular recognition site; other site
321314004557	dimerization interface [polypeptide binding]; other site
321314004558	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314004559	DNA binding residues [nucleotide binding]
321314004560	dimerization interface [polypeptide binding]; other site
321314004561	two component system sensor kinase SsrA; Provisional; Region: PRK15347
321314004562	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314004563	dimerization interface [polypeptide binding]; other site
321314004564	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314004565	dimer interface [polypeptide binding]; other site
321314004566	phosphorylation site [posttranslational modification]
321314004567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314004568	ATP binding site [chemical binding]; other site
321314004569	Mg2+ binding site [ion binding]; other site
321314004570	G-X-G motif; other site
321314004571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314004572	active site
321314004573	phosphorylation site [posttranslational modification]
321314004574	intermolecular recognition site; other site
321314004575	dimerization interface [polypeptide binding]; other site
321314004576	pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368
321314004577	outer membrane secretin SsaC; Provisional; Region: PRK15346
321314004578	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
321314004579	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
321314004580	type III secretion system protein SsaD; Provisional; Region: PRK15367
321314004581	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
321314004582	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
321314004583	type III secretion system chaperone SseA; Provisional; Region: PRK15365
321314004584	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
321314004585	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
321314004586	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
321314004587	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
321314004588	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
321314004589	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
321314004590	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
321314004591	TPR motif; other site
321314004592	binding surface
321314004593	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
321314004594	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
321314004595	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
321314004596	type III secretion system protein SsaH; Provisional; Region: PRK15356
321314004597	type III secretion system protein SsaI; Provisional; Region: PRK15355
321314004598	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
321314004599	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
321314004600	type III secretion system protein SsaK; Provisional; Region: PRK15354
321314004601	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
321314004602	type III secretion system protein SsaL; Provisional; Region: PRK15345
321314004603	HrpJ-like domain; Region: HrpJ; pfam07201
321314004604	TyeA; Region: TyeA; cl07611
321314004605	type III secretion system protein SsaM; Provisional; Region: PRK15353
321314004606	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
321314004607	FHIPEP family; Region: FHIPEP; pfam00771
321314004608	type III secretion system ATPase SsaN; Validated; Region: PRK07594
321314004609	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
321314004610	Walker A motif; other site
321314004611	ATP binding site [chemical binding]; other site
321314004612	Walker B motif; other site
321314004613	type III secretion system protein SsaO; Provisional; Region: PRK15352
321314004614	type III secretion system protein SsaP; Provisional; Region: PRK15351
321314004615	type III secretion system protein SsaQ; Validated; Region: PRK08035
321314004616	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
321314004617	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
321314004618	type III secretion system protein SsaS; Provisional; Region: PRK15350
321314004619	type III secretion system protein SsaT; Provisional; Region: PRK15349
321314004620	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
321314004621	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
321314004622	multidrug efflux protein; Reviewed; Region: PRK01766
321314004623	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
321314004624	cation binding site [ion binding]; other site
321314004625	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
321314004626	Lumazine binding domain; Region: Lum_binding; pfam00677
321314004627	Lumazine binding domain; Region: Lum_binding; pfam00677
321314004628	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
321314004629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314004630	S-adenosylmethionine binding site [chemical binding]; other site
321314004631	putative transporter; Provisional; Region: PRK11043
321314004632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004633	putative substrate translocation pore; other site
321314004634	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
321314004635	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314004636	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314004637	dimerization interface [polypeptide binding]; other site
321314004638	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
321314004639	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314004640	DNA binding site [nucleotide binding]
321314004641	domain linker motif; other site
321314004642	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
321314004643	dimerization interface [polypeptide binding]; other site
321314004644	ligand binding site [chemical binding]; other site
321314004645	superoxide dismutase; Provisional; Region: PRK10543
321314004646	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
321314004647	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
321314004648	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
321314004649	NlpC/P60 family; Region: NLPC_P60; pfam00877
321314004650	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
321314004651	putative GSH binding site [chemical binding]; other site
321314004652	catalytic residues [active]
321314004653	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
321314004654	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
321314004655	dimer interface [polypeptide binding]; other site
321314004656	catalytic site [active]
321314004657	putative active site [active]
321314004658	putative substrate binding site [chemical binding]; other site
321314004659	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
321314004660	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
321314004661	dimer interface [polypeptide binding]; other site
321314004662	active site
321314004663	metal binding site [ion binding]; metal-binding site
321314004664	glutathione binding site [chemical binding]; other site
321314004665	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
321314004666	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
321314004667	FMN binding site [chemical binding]; other site
321314004668	active site
321314004669	substrate binding site [chemical binding]; other site
321314004670	catalytic residue [active]
321314004671	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
321314004672	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314004673	Predicted Fe-S protein [General function prediction only]; Region: COG3313
321314004674	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314004675	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314004676	active site
321314004677	catalytic tetrad [active]
321314004678	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
321314004679	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
321314004680	E-class dimer interface [polypeptide binding]; other site
321314004681	P-class dimer interface [polypeptide binding]; other site
321314004682	active site
321314004683	Cu2+ binding site [ion binding]; other site
321314004684	Zn2+ binding site [ion binding]; other site
321314004685	Fusaric acid resistance protein family; Region: FUSC; pfam04632
321314004686	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
321314004687	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
321314004688	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314004689	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314004690	transcriptional regulator SlyA; Provisional; Region: PRK03573
321314004691	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
321314004692	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
321314004693	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
321314004694	lysozyme inhibitor; Provisional; Region: PRK11372
321314004695	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
321314004696	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
321314004697	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
321314004698	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
321314004699	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
321314004700	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
321314004701	active site
321314004702	HIGH motif; other site
321314004703	dimer interface [polypeptide binding]; other site
321314004704	KMSKS motif; other site
321314004705	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314004706	RNA binding surface [nucleotide binding]; other site
321314004707	pyridoxamine kinase; Validated; Region: PRK05756
321314004708	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
321314004709	dimer interface [polypeptide binding]; other site
321314004710	pyridoxal binding site [chemical binding]; other site
321314004711	ATP binding site [chemical binding]; other site
321314004712	glutathionine S-transferase; Provisional; Region: PRK10542
321314004713	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
321314004714	C-terminal domain interface [polypeptide binding]; other site
321314004715	GSH binding site (G-site) [chemical binding]; other site
321314004716	dimer interface [polypeptide binding]; other site
321314004717	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
321314004718	dimer interface [polypeptide binding]; other site
321314004719	N-terminal domain interface [polypeptide binding]; other site
321314004720	substrate binding pocket (H-site) [chemical binding]; other site
321314004721	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
321314004722	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004723	putative substrate translocation pore; other site
321314004724	POT family; Region: PTR2; pfam00854
321314004725	endonuclease III; Provisional; Region: PRK10702
321314004726	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
321314004727	minor groove reading motif; other site
321314004728	helix-hairpin-helix signature motif; other site
321314004729	substrate binding pocket [chemical binding]; other site
321314004730	active site
321314004731	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
321314004732	electron transport complex RsxE subunit; Provisional; Region: PRK12405
321314004733	electron transport complex protein RnfG; Validated; Region: PRK01908
321314004734	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
321314004735	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
321314004736	SLBB domain; Region: SLBB; pfam10531
321314004737	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
321314004738	electron transport complex protein RnfB; Provisional; Region: PRK05113
321314004739	Putative Fe-S cluster; Region: FeS; cl17515
321314004740	4Fe-4S binding domain; Region: Fer4; pfam00037
321314004741	electron transport complex protein RsxA; Provisional; Region: PRK05151
321314004742	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
321314004743	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
321314004744	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
321314004745	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
321314004746	active site
321314004747	purine riboside binding site [chemical binding]; other site
321314004748	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
321314004749	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
321314004750	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
321314004751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
321314004752	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
321314004753	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
321314004754	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
321314004755	fumarate hydratase; Provisional; Region: PRK15389
321314004756	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
321314004757	Fumarase C-terminus; Region: Fumerase_C; pfam05683
321314004758	fumarate hydratase; Reviewed; Region: fumC; PRK00485
321314004759	Class II fumarases; Region: Fumarase_classII; cd01362
321314004760	active site
321314004761	tetramer interface [polypeptide binding]; other site
321314004762	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
321314004763	sensor protein RstB; Provisional; Region: PRK10604
321314004764	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314004765	dimerization interface [polypeptide binding]; other site
321314004766	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314004767	dimer interface [polypeptide binding]; other site
321314004768	phosphorylation site [posttranslational modification]
321314004769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314004770	ATP binding site [chemical binding]; other site
321314004771	Mg2+ binding site [ion binding]; other site
321314004772	G-X-G motif; other site
321314004773	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
321314004774	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
321314004775	active site
321314004776	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314004777	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
321314004778	trimer interface [polypeptide binding]; other site
321314004779	eyelet of channel; other site
321314004780	Domain of unknown function (DUF1744); Region: DUF1744; pfam08490
321314004781	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
321314004782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314004783	active site
321314004784	phosphorylation site [posttranslational modification]
321314004785	intermolecular recognition site; other site
321314004786	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314004787	DNA binding site [nucleotide binding]
321314004788	GlpM protein; Region: GlpM; pfam06942
321314004789	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
321314004790	Spore germination protein; Region: Spore_permease; cl17796
321314004791	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314004792	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314004793	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314004794	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
321314004795	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
321314004796	ligand binding site [chemical binding]; other site
321314004797	homodimer interface [polypeptide binding]; other site
321314004798	NAD(P) binding site [chemical binding]; other site
321314004799	trimer interface B [polypeptide binding]; other site
321314004800	trimer interface A [polypeptide binding]; other site
321314004801	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
321314004802	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
321314004803	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
321314004804	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
321314004805	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
321314004806	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
321314004807	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
321314004808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004809	putative substrate translocation pore; other site
321314004810	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
321314004811	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314004812	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
321314004813	dimerization interface [polypeptide binding]; other site
321314004814	substrate binding pocket [chemical binding]; other site
321314004815	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
321314004816	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
321314004817	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314004818	nucleotide binding site [chemical binding]; other site
321314004819	putative dithiobiotin synthetase; Provisional; Region: PRK12374
321314004820	AAA domain; Region: AAA_26; pfam13500
321314004821	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
321314004822	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
321314004823	Walker A/P-loop; other site
321314004824	ATP binding site [chemical binding]; other site
321314004825	Q-loop/lid; other site
321314004826	ABC transporter signature motif; other site
321314004827	Walker B; other site
321314004828	D-loop; other site
321314004829	H-loop/switch region; other site
321314004830	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
321314004831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314004832	dimer interface [polypeptide binding]; other site
321314004833	conserved gate region; other site
321314004834	ABC-ATPase subunit interface; other site
321314004835	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
321314004836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314004837	dimer interface [polypeptide binding]; other site
321314004838	conserved gate region; other site
321314004839	putative PBP binding loops; other site
321314004840	ABC-ATPase subunit interface; other site
321314004841	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
321314004842	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
321314004843	4Fe-4S binding domain; Region: Fer4; cl02805
321314004844	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
321314004845	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
321314004846	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
321314004847	putative [Fe4-S4] binding site [ion binding]; other site
321314004848	putative molybdopterin cofactor binding site [chemical binding]; other site
321314004849	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
321314004850	putative molybdopterin cofactor binding site; other site
321314004851	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
321314004852	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
321314004853	putative [Fe4-S4] binding site [ion binding]; other site
321314004854	putative molybdopterin cofactor binding site [chemical binding]; other site
321314004855	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
321314004856	putative molybdopterin cofactor binding site; other site
321314004857	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
321314004858	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
321314004859	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
321314004860	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314004861	Coenzyme A binding pocket [chemical binding]; other site
321314004862	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
321314004863	hypothetical protein; Provisional; Region: PRK13659
321314004864	hypothetical protein; Provisional; Region: PRK02237
321314004865	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
321314004866	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
321314004867	putative active site pocket [active]
321314004868	putative metal binding site [ion binding]; other site
321314004869	putative oxidoreductase; Provisional; Region: PRK10083
321314004870	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
321314004871	putative NAD(P) binding site [chemical binding]; other site
321314004872	catalytic Zn binding site [ion binding]; other site
321314004873	structural Zn binding site [ion binding]; other site
321314004874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004875	metabolite-proton symporter; Region: 2A0106; TIGR00883
321314004876	putative substrate translocation pore; other site
321314004877	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
321314004878	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
321314004879	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
321314004880	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
321314004881	Transcriptional regulators [Transcription]; Region: GntR; COG1802
321314004882	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314004883	DNA-binding site [nucleotide binding]; DNA binding site
321314004884	FCD domain; Region: FCD; pfam07729
321314004885	malonic semialdehyde reductase; Provisional; Region: PRK10538
321314004886	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
321314004887	putative NAD(P) binding site [chemical binding]; other site
321314004888	homodimer interface [polypeptide binding]; other site
321314004889	homotetramer interface [polypeptide binding]; other site
321314004890	active site
321314004891	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
321314004892	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
321314004893	active site
321314004894	Zn binding site [ion binding]; other site
321314004895	General stress protein [General function prediction only]; Region: GsiB; COG3729
321314004896	hypothetical protein; Validated; Region: PRK03657
321314004897	hypothetical protein; Provisional; Region: PRK10053
321314004898	putative transporter; Provisional; Region: PRK10054
321314004899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004900	putative substrate translocation pore; other site
321314004901	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
321314004902	EamA-like transporter family; Region: EamA; pfam00892
321314004903	MarB protein; Region: MarB; pfam13999
321314004904	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
321314004905	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314004906	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314004907	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
321314004908	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
321314004909	inner membrane protein; Provisional; Region: PRK10995
321314004910	putative arabinose transporter; Provisional; Region: PRK03545
321314004911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004912	putative substrate translocation pore; other site
321314004913	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
321314004914	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
321314004915	NAD(P) binding site [chemical binding]; other site
321314004916	catalytic residues [active]
321314004917	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
321314004918	glutaminase; Provisional; Region: PRK00971
321314004919	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
321314004920	Predicted membrane protein [Function unknown]; Region: COG3781
321314004921	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
321314004922	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314004923	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
321314004924	trimer interface [polypeptide binding]; other site
321314004925	eyelet of channel; other site
321314004926	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
321314004927	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
321314004928	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
321314004929	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
321314004930	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
321314004931	Rubredoxin [Energy production and conversion]; Region: COG1773
321314004932	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
321314004933	iron binding site [ion binding]; other site
321314004934	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
321314004935	HupF/HypC family; Region: HupF_HypC; cl00394
321314004936	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
321314004937	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
321314004938	putative substrate-binding site; other site
321314004939	nickel binding site [ion binding]; other site
321314004940	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
321314004941	hydrogenase 1 large subunit; Provisional; Region: PRK10170
321314004942	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
321314004943	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
321314004944	hydrogenase 1 large subunit; Provisional; Region: PRK10170
321314004945	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
321314004946	hypothetical protein; Provisional; Region: PRK06184
321314004947	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
321314004948	active site
321314004949	catalytic site [active]
321314004950	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
321314004951	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
321314004952	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
321314004953	catalytic site [active]
321314004954	active site
321314004955	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
321314004956	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
321314004957	acid-resistance protein; Provisional; Region: hdeB; PRK11566
321314004958	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
321314004959	biofilm-dependent modulation protein; Provisional; Region: PRK11436
321314004960	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
321314004961	malate dehydrogenase; Provisional; Region: PRK13529
321314004962	Malic enzyme, N-terminal domain; Region: malic; pfam00390
321314004963	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
321314004964	NAD(P) binding site [chemical binding]; other site
321314004965	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
321314004966	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
321314004967	NAD binding site [chemical binding]; other site
321314004968	substrate binding site [chemical binding]; other site
321314004969	catalytic Zn binding site [ion binding]; other site
321314004970	tetramer interface [polypeptide binding]; other site
321314004971	structural Zn binding site [ion binding]; other site
321314004972	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
321314004973	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
321314004974	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
321314004975	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
321314004976	aromatic amino acid exporter; Provisional; Region: PRK11689
321314004977	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314004978	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
321314004979	trimer interface [polypeptide binding]; other site
321314004980	eyelet of channel; other site
321314004981	Uncharacterized conserved protein [Function unknown]; Region: COG3791
321314004982	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
321314004983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314004984	putative substrate translocation pore; other site
321314004985	TetR family transcriptional regulator; Provisional; Region: PRK14996
321314004986	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314004987	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
321314004988	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
321314004989	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
321314004990	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
321314004991	hypothetical protein; Provisional; Region: PRK10281
321314004992	N-acetyltransferase; Region: Acetyltransf_2; cl00949
321314004993	L-asparagine permease; Provisional; Region: PRK15049
321314004994	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
321314004995	Uncharacterized conserved protein [Function unknown]; Region: COG3391
321314004996	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
321314004997	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
321314004998	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314004999	N-terminal plug; other site
321314005000	ligand-binding site [chemical binding]; other site
321314005001	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
321314005002	Prostaglandin dehydrogenases; Region: PGDH; cd05288
321314005003	NAD(P) binding site [chemical binding]; other site
321314005004	substrate binding site [chemical binding]; other site
321314005005	dimer interface [polypeptide binding]; other site
321314005006	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
321314005007	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
321314005008	Coenzyme A binding pocket [chemical binding]; other site
321314005009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
321314005010	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
321314005011	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
321314005012	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
321314005013	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
321314005014	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
321314005015	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
321314005016	tetrameric interface [polypeptide binding]; other site
321314005017	NAD binding site [chemical binding]; other site
321314005018	catalytic residues [active]
321314005019	substrate binding site [chemical binding]; other site
321314005020	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
321314005021	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314005022	DNA-binding site [nucleotide binding]; DNA binding site
321314005023	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314005024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314005025	homodimer interface [polypeptide binding]; other site
321314005026	catalytic residue [active]
321314005027	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
321314005028	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
321314005029	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
321314005030	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
321314005031	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
321314005032	Peptidase family U32; Region: Peptidase_U32; pfam01136
321314005033	Collagenase; Region: DUF3656; pfam12392
321314005034	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
321314005035	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314005036	non-specific DNA binding site [nucleotide binding]; other site
321314005037	salt bridge; other site
321314005038	sequence-specific DNA binding site [nucleotide binding]; other site
321314005039	Cupin domain; Region: Cupin_2; pfam07883
321314005040	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
321314005041	benzoate transporter; Region: benE; TIGR00843
321314005042	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
321314005043	tellurite resistance protein TehB; Provisional; Region: PRK11207
321314005044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314005045	S-adenosylmethionine binding site [chemical binding]; other site
321314005046	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
321314005047	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
321314005048	gating phenylalanine in ion channel; other site
321314005049	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
321314005050	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314005051	Coenzyme A binding pocket [chemical binding]; other site
321314005052	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
321314005053	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
321314005054	oligomer interface [polypeptide binding]; other site
321314005055	active site
321314005056	metal binding site [ion binding]; metal-binding site
321314005057	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
321314005058	active site
321314005059	P-loop; other site
321314005060	phosphorylation site [posttranslational modification]
321314005061	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
321314005062	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
321314005063	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
321314005064	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314005065	active site
321314005066	phosphorylation site [posttranslational modification]
321314005067	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
321314005068	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
321314005069	substrate binding site [chemical binding]; other site
321314005070	hexamer interface [polypeptide binding]; other site
321314005071	metal binding site [ion binding]; metal-binding site
321314005072	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314005073	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
321314005074	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314005075	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
321314005076	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314005077	Coenzyme A binding pocket [chemical binding]; other site
321314005078	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
321314005079	teramer interface [polypeptide binding]; other site
321314005080	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
321314005081	active site
321314005082	FMN binding site [chemical binding]; other site
321314005083	catalytic residues [active]
321314005084	Uncharacterized conserved protein [Function unknown]; Region: COG2353
321314005085	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
321314005086	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
321314005087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
321314005088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
321314005089	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
321314005090	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314005091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314005092	dimerization interface [polypeptide binding]; other site
321314005093	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
321314005094	dimer interface [polypeptide binding]; other site
321314005095	ligand binding site [chemical binding]; other site
321314005096	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
321314005097	HAMP domain; Region: HAMP; pfam00672
321314005098	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314005099	dimer interface [polypeptide binding]; other site
321314005100	putative CheW interface [polypeptide binding]; other site
321314005101	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
321314005102	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
321314005103	substrate binding site [chemical binding]; other site
321314005104	catalytic Zn binding site [ion binding]; other site
321314005105	NAD binding site [chemical binding]; other site
321314005106	structural Zn binding site [ion binding]; other site
321314005107	dimer interface [polypeptide binding]; other site
321314005108	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
321314005109	putative metal binding site [ion binding]; other site
321314005110	putative homodimer interface [polypeptide binding]; other site
321314005111	putative homotetramer interface [polypeptide binding]; other site
321314005112	putative homodimer-homodimer interface [polypeptide binding]; other site
321314005113	putative allosteric switch controlling residues; other site
321314005114	Sif protein; Region: Sif; cl11505
321314005115	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
321314005116	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
321314005117	active site
321314005118	catalytic triad [active]
321314005119	oxyanion hole [active]
321314005120	Predicted membrane protein [Function unknown]; Region: COG3326
321314005121	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
321314005122	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314005123	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314005124	dimer interface [polypeptide binding]; other site
321314005125	conserved gate region; other site
321314005126	putative PBP binding loops; other site
321314005127	ABC-ATPase subunit interface; other site
321314005128	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
321314005129	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314005130	Walker A/P-loop; other site
321314005131	ATP binding site [chemical binding]; other site
321314005132	Q-loop/lid; other site
321314005133	ABC transporter signature motif; other site
321314005134	Walker B; other site
321314005135	D-loop; other site
321314005136	H-loop/switch region; other site
321314005137	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314005138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314005139	dimer interface [polypeptide binding]; other site
321314005140	conserved gate region; other site
321314005141	putative PBP binding loops; other site
321314005142	ABC-ATPase subunit interface; other site
321314005143	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
321314005144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314005145	S-adenosylmethionine binding site [chemical binding]; other site
321314005146	Uncharacterized conserved protein [Function unknown]; Region: COG1434
321314005147	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
321314005148	putative active site [active]
321314005149	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
321314005150	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314005151	ATP binding site [chemical binding]; other site
321314005152	putative Mg++ binding site [ion binding]; other site
321314005153	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314005154	nucleotide binding region [chemical binding]; other site
321314005155	ATP-binding site [chemical binding]; other site
321314005156	Helicase associated domain (HA2); Region: HA2; pfam04408
321314005157	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
321314005158	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
321314005159	azoreductase; Reviewed; Region: PRK00170
321314005160	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
321314005161	Uncharacterized conserved protein [Function unknown]; Region: COG3791
321314005162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
321314005163	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
321314005164	hypothetical protein; Provisional; Region: PRK10695
321314005165	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
321314005166	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
321314005167	putative ligand binding site [chemical binding]; other site
321314005168	putative NAD binding site [chemical binding]; other site
321314005169	catalytic site [active]
321314005170	heat-inducible protein; Provisional; Region: PRK10449
321314005171	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
321314005172	Domain of unknown function (DUF333); Region: DUF333; pfam03891
321314005173	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
321314005174	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
321314005175	dimer interface [polypeptide binding]; other site
321314005176	PYR/PP interface [polypeptide binding]; other site
321314005177	TPP binding site [chemical binding]; other site
321314005178	substrate binding site [chemical binding]; other site
321314005179	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
321314005180	Domain of unknown function; Region: EKR; smart00890
321314005181	4Fe-4S binding domain; Region: Fer4_6; pfam12837
321314005182	4Fe-4S binding domain; Region: Fer4; pfam00037
321314005183	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
321314005184	TPP-binding site [chemical binding]; other site
321314005185	dimer interface [polypeptide binding]; other site
321314005186	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
321314005187	Ligand Binding Site [chemical binding]; other site
321314005188	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
321314005189	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
321314005190	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
321314005191	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
321314005192	Ligand Binding Site [chemical binding]; other site
321314005193	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
321314005194	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
321314005195	ATP binding site [chemical binding]; other site
321314005196	Mg++ binding site [ion binding]; other site
321314005197	motif III; other site
321314005198	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314005199	nucleotide binding region [chemical binding]; other site
321314005200	ATP-binding site [chemical binding]; other site
321314005201	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
321314005202	putative RNA binding site [nucleotide binding]; other site
321314005203	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
321314005204	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
321314005205	Cl binding site [ion binding]; other site
321314005206	oligomer interface [polypeptide binding]; other site
321314005207	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
321314005208	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314005209	dimer interface [polypeptide binding]; other site
321314005210	putative CheW interface [polypeptide binding]; other site
321314005211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
321314005212	Smr domain; Region: Smr; pfam01713
321314005213	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
321314005214	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
321314005215	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
321314005216	DNA binding site [nucleotide binding]
321314005217	active site
321314005218	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
321314005219	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
321314005220	ligand binding site [chemical binding]; other site
321314005221	flexible hinge region; other site
321314005222	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
321314005223	putative switch regulator; other site
321314005224	non-specific DNA interactions [nucleotide binding]; other site
321314005225	DNA binding site [nucleotide binding]
321314005226	sequence specific DNA binding site [nucleotide binding]; other site
321314005227	putative cAMP binding site [chemical binding]; other site
321314005228	universal stress protein UspE; Provisional; Region: PRK11175
321314005229	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
321314005230	Ligand Binding Site [chemical binding]; other site
321314005231	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
321314005232	Ligand Binding Site [chemical binding]; other site
321314005233	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
321314005234	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
321314005235	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314005236	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
321314005237	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314005238	non-specific DNA binding site [nucleotide binding]; other site
321314005239	salt bridge; other site
321314005240	sequence-specific DNA binding site [nucleotide binding]; other site
321314005241	Cupin domain; Region: Cupin_2; pfam07883
321314005242	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
321314005243	B3/4 domain; Region: B3_4; pfam03483
321314005244	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
321314005245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314005246	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
321314005247	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
321314005248	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
321314005249	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314005250	oxidoreductase; Provisional; Region: PRK12742
321314005251	classical (c) SDRs; Region: SDR_c; cd05233
321314005252	NAD(P) binding site [chemical binding]; other site
321314005253	active site
321314005254	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314005255	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314005256	active site
321314005257	catalytic tetrad [active]
321314005258	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314005259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314005260	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
321314005261	putative effector binding pocket; other site
321314005262	putative dimerization interface [polypeptide binding]; other site
321314005263	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
321314005264	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
321314005265	peptide binding site [polypeptide binding]; other site
321314005266	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
321314005267	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
321314005268	putative active site [active]
321314005269	Zn binding site [ion binding]; other site
321314005270	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
321314005271	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
321314005272	active site
321314005273	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
321314005274	dimer interface [polypeptide binding]; other site
321314005275	catalytic triad [active]
321314005276	peroxidatic and resolving cysteines [active]
321314005277	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
321314005278	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
321314005279	putative aromatic amino acid binding site; other site
321314005280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314005281	Walker A motif; other site
321314005282	ATP binding site [chemical binding]; other site
321314005283	Walker B motif; other site
321314005284	arginine finger; other site
321314005285	hypothetical protein; Provisional; Region: PRK05415
321314005286	TIGR01620 family protein; Region: hyp_HI0043
321314005287	Predicted ATPase [General function prediction only]; Region: COG3106
321314005288	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
321314005289	active site residue [active]
321314005290	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
321314005291	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
321314005292	phage shock protein C; Region: phageshock_pspC; TIGR02978
321314005293	phage shock protein B; Provisional; Region: pspB; PRK09458
321314005294	phage shock protein PspA; Provisional; Region: PRK10698
321314005295	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
321314005296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314005297	Walker A motif; other site
321314005298	ATP binding site [chemical binding]; other site
321314005299	Walker B motif; other site
321314005300	arginine finger; other site
321314005301	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
321314005302	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
321314005303	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
321314005304	peptide binding site [polypeptide binding]; other site
321314005305	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
321314005306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314005307	dimer interface [polypeptide binding]; other site
321314005308	conserved gate region; other site
321314005309	putative PBP binding loops; other site
321314005310	ABC-ATPase subunit interface; other site
321314005311	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
321314005312	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
321314005313	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314005314	dimer interface [polypeptide binding]; other site
321314005315	conserved gate region; other site
321314005316	putative PBP binding loops; other site
321314005317	ABC-ATPase subunit interface; other site
321314005318	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
321314005319	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314005320	Walker A/P-loop; other site
321314005321	ATP binding site [chemical binding]; other site
321314005322	Q-loop/lid; other site
321314005323	ABC transporter signature motif; other site
321314005324	Walker B; other site
321314005325	D-loop; other site
321314005326	H-loop/switch region; other site
321314005327	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
321314005328	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
321314005329	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314005330	Walker A/P-loop; other site
321314005331	ATP binding site [chemical binding]; other site
321314005332	Q-loop/lid; other site
321314005333	ABC transporter signature motif; other site
321314005334	Walker B; other site
321314005335	D-loop; other site
321314005336	H-loop/switch region; other site
321314005337	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
321314005338	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
321314005339	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
321314005340	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
321314005341	NAD binding site [chemical binding]; other site
321314005342	homotetramer interface [polypeptide binding]; other site
321314005343	homodimer interface [polypeptide binding]; other site
321314005344	substrate binding site [chemical binding]; other site
321314005345	active site
321314005346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
321314005347	exoribonuclease II; Provisional; Region: PRK05054
321314005348	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
321314005349	RNB domain; Region: RNB; pfam00773
321314005350	S1 RNA binding domain; Region: S1; pfam00575
321314005351	RNase II stability modulator; Provisional; Region: PRK10060
321314005352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314005353	putative active site [active]
321314005354	heme pocket [chemical binding]; other site
321314005355	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314005356	metal binding site [ion binding]; metal-binding site
321314005357	active site
321314005358	I-site; other site
321314005359	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314005360	hypothetical protein; Provisional; Region: PRK13658
321314005361	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314005362	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
321314005363	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314005364	lipoprotein; Provisional; Region: PRK10540
321314005365	translation initiation factor Sui1; Validated; Region: PRK06824
321314005366	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
321314005367	putative rRNA binding site [nucleotide binding]; other site
321314005368	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
321314005369	active site
321314005370	dimer interface [polypeptide binding]; other site
321314005371	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
321314005372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
321314005373	TPR motif; other site
321314005374	binding surface
321314005375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
321314005376	binding surface
321314005377	TPR motif; other site
321314005378	Predicted membrane protein [Function unknown]; Region: COG3771
321314005379	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
321314005380	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
321314005381	active site
321314005382	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
321314005383	dimerization interface [polypeptide binding]; other site
321314005384	active site
321314005385	aconitate hydratase; Validated; Region: PRK09277
321314005386	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
321314005387	substrate binding site [chemical binding]; other site
321314005388	ligand binding site [chemical binding]; other site
321314005389	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
321314005390	substrate binding site [chemical binding]; other site
321314005391	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
321314005392	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314005393	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
321314005394	substrate binding site [chemical binding]; other site
321314005395	putative dimerization interface [polypeptide binding]; other site
321314005396	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
321314005397	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
321314005398	active site
321314005399	interdomain interaction site; other site
321314005400	putative metal-binding site [ion binding]; other site
321314005401	nucleotide binding site [chemical binding]; other site
321314005402	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
321314005403	domain I; other site
321314005404	DNA binding groove [nucleotide binding]
321314005405	phosphate binding site [ion binding]; other site
321314005406	domain II; other site
321314005407	domain III; other site
321314005408	nucleotide binding site [chemical binding]; other site
321314005409	catalytic site [active]
321314005410	domain IV; other site
321314005411	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
321314005412	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
321314005413	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
321314005414	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
321314005415	hypothetical protein; Provisional; Region: PRK11037
321314005416	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
321314005417	putative inner membrane peptidase; Provisional; Region: PRK11778
321314005418	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
321314005419	tandem repeat interface [polypeptide binding]; other site
321314005420	oligomer interface [polypeptide binding]; other site
321314005421	active site residues [active]
321314005422	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
321314005423	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
321314005424	NADP binding site [chemical binding]; other site
321314005425	homodimer interface [polypeptide binding]; other site
321314005426	active site
321314005427	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
321314005428	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
321314005429	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
321314005430	homodimer interface [polypeptide binding]; other site
321314005431	Walker A motif; other site
321314005432	ATP binding site [chemical binding]; other site
321314005433	hydroxycobalamin binding site [chemical binding]; other site
321314005434	Walker B motif; other site
321314005435	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
321314005436	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314005437	RNA binding surface [nucleotide binding]; other site
321314005438	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
321314005439	probable active site [active]
321314005440	hypothetical protein; Provisional; Region: PRK11630
321314005441	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
321314005442	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
321314005443	active site
321314005444	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
321314005445	anthranilate synthase component I; Provisional; Region: PRK13564
321314005446	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
321314005447	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
321314005448	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
321314005449	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
321314005450	glutamine binding [chemical binding]; other site
321314005451	catalytic triad [active]
321314005452	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
321314005453	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
321314005454	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
321314005455	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
321314005456	active site
321314005457	ribulose/triose binding site [chemical binding]; other site
321314005458	phosphate binding site [ion binding]; other site
321314005459	substrate (anthranilate) binding pocket [chemical binding]; other site
321314005460	product (indole) binding pocket [chemical binding]; other site
321314005461	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
321314005462	active site
321314005463	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
321314005464	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
321314005465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314005466	catalytic residue [active]
321314005467	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
321314005468	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
321314005469	substrate binding site [chemical binding]; other site
321314005470	active site
321314005471	catalytic residues [active]
321314005472	heterodimer interface [polypeptide binding]; other site
321314005473	General stress protein [General function prediction only]; Region: GsiB; COG3729
321314005474	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
321314005475	dimerization interface [polypeptide binding]; other site
321314005476	metal binding site [ion binding]; metal-binding site
321314005477	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
321314005478	dinuclear metal binding motif [ion binding]; other site
321314005479	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
321314005480	dimanganese center [ion binding]; other site
321314005481	outer membrane protein W; Provisional; Region: PRK10959
321314005482	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
321314005483	hypothetical protein; Provisional; Region: PRK02868
321314005484	intracellular septation protein A; Reviewed; Region: PRK00259
321314005485	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
321314005486	transport protein TonB; Provisional; Region: PRK10819
321314005487	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
321314005488	YciI-like protein; Reviewed; Region: PRK11370
321314005489	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
321314005490	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
321314005491	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
321314005492	putative active site [active]
321314005493	catalytic site [active]
321314005494	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
321314005495	putative active site [active]
321314005496	catalytic site [active]
321314005497	dsDNA-mimic protein; Reviewed; Region: PRK05094
321314005498	Ion transport protein; Region: Ion_trans; pfam00520
321314005499	Ion channel; Region: Ion_trans_2; pfam07885
321314005500	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
321314005501	Double zinc ribbon; Region: DZR; pfam12773
321314005502	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
321314005503	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314005504	Walker A/P-loop; other site
321314005505	ATP binding site [chemical binding]; other site
321314005506	Q-loop/lid; other site
321314005507	ABC transporter signature motif; other site
321314005508	Walker B; other site
321314005509	D-loop; other site
321314005510	H-loop/switch region; other site
321314005511	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
321314005512	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
321314005513	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314005514	Walker A/P-loop; other site
321314005515	ATP binding site [chemical binding]; other site
321314005516	Q-loop/lid; other site
321314005517	ABC transporter signature motif; other site
321314005518	Walker B; other site
321314005519	D-loop; other site
321314005520	H-loop/switch region; other site
321314005521	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
321314005522	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
321314005523	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
321314005524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314005525	dimer interface [polypeptide binding]; other site
321314005526	conserved gate region; other site
321314005527	ABC-ATPase subunit interface; other site
321314005528	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
321314005529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314005530	dimer interface [polypeptide binding]; other site
321314005531	conserved gate region; other site
321314005532	putative PBP binding loops; other site
321314005533	ABC-ATPase subunit interface; other site
321314005534	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
321314005535	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
321314005536	peptide binding site [polypeptide binding]; other site
321314005537	hypothetical protein; Provisional; Region: PRK11111
321314005538	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
321314005539	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
321314005540	putative catalytic cysteine [active]
321314005541	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
321314005542	putative active site [active]
321314005543	metal binding site [ion binding]; metal-binding site
321314005544	thymidine kinase; Provisional; Region: PRK04296
321314005545	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
321314005546	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
321314005547	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
321314005548	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
321314005549	active site
321314005550	tetramer interface; other site
321314005551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314005552	active site
321314005553	response regulator of RpoS; Provisional; Region: PRK10693
321314005554	phosphorylation site [posttranslational modification]
321314005555	intermolecular recognition site; other site
321314005556	dimerization interface [polypeptide binding]; other site
321314005557	hypothetical protein; Provisional; Region: PRK10279
321314005558	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
321314005559	active site
321314005560	nucleophile elbow; other site
321314005561	SEC-C motif; Region: SEC-C; pfam02810
321314005562	hypothetical protein; Provisional; Region: PRK04233
321314005563	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
321314005564	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
321314005565	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
321314005566	putative active site [active]
321314005567	putative substrate binding site [chemical binding]; other site
321314005568	putative cosubstrate binding site; other site
321314005569	catalytic site [active]
321314005570	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314005571	Sel1-like repeats; Region: SEL1; smart00671
321314005572	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314005573	Sel1-like repeats; Region: SEL1; smart00671
321314005574	Sel1-like repeats; Region: SEL1; smart00671
321314005575	Sel1-like repeats; Region: SEL1; smart00671
321314005576	Sel1-like repeats; Region: SEL1; smart00671
321314005577	Sel1-like repeats; Region: SEL1; smart00671
321314005578	Sel1-like repeats; Region: SEL1; smart00671
321314005579	Sel1-like repeats; Region: SEL1; smart00671
321314005580	Sel1-like repeats; Region: SEL1; smart00671
321314005581	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
321314005582	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
321314005583	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
321314005584	4Fe-4S binding domain; Region: Fer4; cl02805
321314005585	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
321314005586	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
321314005587	[4Fe-4S] binding site [ion binding]; other site
321314005588	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
321314005589	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
321314005590	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
321314005591	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
321314005592	molybdopterin cofactor binding site; other site
321314005593	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
321314005594	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
321314005595	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
321314005596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314005597	dimerization interface [polypeptide binding]; other site
321314005598	Histidine kinase; Region: HisKA_3; pfam07730
321314005599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314005600	ATP binding site [chemical binding]; other site
321314005601	Mg2+ binding site [ion binding]; other site
321314005602	G-X-G motif; other site
321314005603	transcriptional regulator NarL; Provisional; Region: PRK10651
321314005604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314005605	active site
321314005606	phosphorylation site [posttranslational modification]
321314005607	intermolecular recognition site; other site
321314005608	dimerization interface [polypeptide binding]; other site
321314005609	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314005610	DNA binding residues [nucleotide binding]
321314005611	dimerization interface [polypeptide binding]; other site
321314005612	putative invasin; Provisional; Region: PRK10177
321314005613	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
321314005614	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
321314005615	cation transport regulator; Reviewed; Region: chaB; PRK09582
321314005616	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
321314005617	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
321314005618	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
321314005619	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
321314005620	hypothetical protein; Provisional; Region: PRK10941
321314005621	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
321314005622	hypothetical protein; Provisional; Region: PRK10278
321314005623	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
321314005624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314005625	peptide chain release factor 1; Validated; Region: prfA; PRK00591
321314005626	This domain is found in peptide chain release factors; Region: PCRF; smart00937
321314005627	RF-1 domain; Region: RF-1; pfam00472
321314005628	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
321314005629	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
321314005630	tRNA; other site
321314005631	putative tRNA binding site [nucleotide binding]; other site
321314005632	putative NADP binding site [chemical binding]; other site
321314005633	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
321314005634	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
321314005635	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
321314005636	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
321314005637	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
321314005638	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
321314005639	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
321314005640	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314005641	active site
321314005642	putative transporter; Provisional; Region: PRK11660
321314005643	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
321314005644	Sulfate transporter family; Region: Sulfate_transp; pfam00916
321314005645	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
321314005646	hypothetical protein; Provisional; Region: PRK10692
321314005647	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
321314005648	putative active site [active]
321314005649	catalytic residue [active]
321314005650	GTP-binding protein YchF; Reviewed; Region: PRK09601
321314005651	YchF GTPase; Region: YchF; cd01900
321314005652	G1 box; other site
321314005653	GTP/Mg2+ binding site [chemical binding]; other site
321314005654	Switch I region; other site
321314005655	G2 box; other site
321314005656	Switch II region; other site
321314005657	G3 box; other site
321314005658	G4 box; other site
321314005659	G5 box; other site
321314005660	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
321314005661	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
321314005662	Protein of unknown function (DUF4427); Region: DUF4427; pfam14468
321314005663	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
321314005664	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
321314005665	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
321314005666	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
321314005667	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
321314005668	putative substrate-binding site; other site
321314005669	nickel binding site [ion binding]; other site
321314005670	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
321314005671	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
321314005672	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
321314005673	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
321314005674	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
321314005675	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
321314005676	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
321314005677	NAD(P) binding site [chemical binding]; other site
321314005678	trehalase; Provisional; Region: treA; PRK13271
321314005679	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
321314005680	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
321314005681	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
321314005682	Flagellar regulator YcgR; Region: YcgR; pfam07317
321314005683	PilZ domain; Region: PilZ; pfam07238
321314005684	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
321314005685	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314005686	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314005687	catalytic residue [active]
321314005688	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
321314005689	dimer interface [polypeptide binding]; other site
321314005690	catalytic triad [active]
321314005691	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
321314005692	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
321314005693	TrkA-C domain; Region: TrkA_C; pfam02080
321314005694	Transporter associated domain; Region: CorC_HlyC; smart01091
321314005695	alanine racemase; Reviewed; Region: dadX; PRK03646
321314005696	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
321314005697	active site
321314005698	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
321314005699	substrate binding site [chemical binding]; other site
321314005700	catalytic residues [active]
321314005701	dimer interface [polypeptide binding]; other site
321314005702	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
321314005703	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
321314005704	SpoVR family protein; Provisional; Region: PRK11767
321314005705	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
321314005706	fatty acid metabolism regulator; Provisional; Region: PRK04984
321314005707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314005708	DNA-binding site [nucleotide binding]; DNA binding site
321314005709	FadR C-terminal domain; Region: FadR_C; pfam07840
321314005710	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
321314005711	transmembrane helices; other site
321314005712	disulfide bond formation protein B; Provisional; Region: PRK01749
321314005713	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
321314005714	GnsA/GnsB family; Region: GnsAB; pfam08178
321314005715	hypothetical protein; Provisional; Region: PRK05170
321314005716	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
321314005717	hypothetical protein; Provisional; Region: PRK10691
321314005718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
321314005719	septum formation inhibitor; Reviewed; Region: minC; PRK03511
321314005720	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
321314005721	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
321314005722	cell division inhibitor MinD; Provisional; Region: PRK10818
321314005723	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
321314005724	Switch I; other site
321314005725	Switch II; other site
321314005726	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
321314005727	ribonuclease D; Provisional; Region: PRK10829
321314005728	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
321314005729	catalytic site [active]
321314005730	putative active site [active]
321314005731	putative substrate binding site [chemical binding]; other site
321314005732	HRDC domain; Region: HRDC; cl02578
321314005733	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
321314005734	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
321314005735	acyl-activating enzyme (AAE) consensus motif; other site
321314005736	putative AMP binding site [chemical binding]; other site
321314005737	putative active site [active]
321314005738	putative CoA binding site [chemical binding]; other site
321314005739	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
321314005740	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
321314005741	Glycoprotease family; Region: Peptidase_M22; pfam00814
321314005742	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
321314005743	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
321314005744	DEAD_2; Region: DEAD_2; pfam06733
321314005745	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
321314005746	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
321314005747	homotrimer interaction site [polypeptide binding]; other site
321314005748	putative active site [active]
321314005749	hypothetical protein; Provisional; Region: PRK05114
321314005750	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
321314005751	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
321314005752	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
321314005753	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
321314005754	putative active site [active]
321314005755	putative CoA binding site [chemical binding]; other site
321314005756	nudix motif; other site
321314005757	metal binding site [ion binding]; metal-binding site
321314005758	L-serine deaminase; Provisional; Region: PRK15023
321314005759	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
321314005760	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
321314005761	phage resistance protein; Provisional; Region: PRK10551
321314005762	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
321314005763	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314005764	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
321314005765	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
321314005766	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
321314005767	Transporter associated domain; Region: CorC_HlyC; smart01091
321314005768	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
321314005769	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
321314005770	active pocket/dimerization site; other site
321314005771	active site
321314005772	phosphorylation site [posttranslational modification]
321314005773	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
321314005774	active site
321314005775	phosphorylation site [posttranslational modification]
321314005776	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
321314005777	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
321314005778	hypothetical protein; Provisional; Region: PRK02913
321314005779	hypothetical protein; Provisional; Region: PRK11469
321314005780	Domain of unknown function DUF; Region: DUF204; pfam02659
321314005781	Domain of unknown function DUF; Region: DUF204; pfam02659
321314005782	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
321314005783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314005784	S-adenosylmethionine binding site [chemical binding]; other site
321314005785	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
321314005786	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
321314005787	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
321314005788	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
321314005789	DNA-binding site [nucleotide binding]; DNA binding site
321314005790	RNA-binding motif; other site
321314005791	Protein of unknown function (DUF2627); Region: DUF2527; pfam10736
321314005792	similar to IS1
321314005793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
321314005794	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
321314005795	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
321314005796	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
321314005797	YebO-like protein; Region: YebO; pfam13974
321314005798	PhoPQ regulatory protein; Provisional; Region: PRK10299
321314005799	YobH-like protein; Region: YobH; pfam13996
321314005800	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
321314005801	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314005802	dimerization interface [polypeptide binding]; other site
321314005803	putative Zn2+ binding site [ion binding]; other site
321314005804	putative DNA binding site [nucleotide binding]; other site
321314005805	Bacterial transcriptional regulator; Region: IclR; pfam01614
321314005806	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314005807	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314005808	putative substrate translocation pore; other site
321314005809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314005810	heat shock protein HtpX; Provisional; Region: PRK05457
321314005811	carboxy-terminal protease; Provisional; Region: PRK11186
321314005812	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
321314005813	protein binding site [polypeptide binding]; other site
321314005814	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
321314005815	Catalytic dyad [active]
321314005816	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
321314005817	ProP expression regulator; Provisional; Region: PRK04950
321314005818	ProQ/FINO family; Region: ProQ; pfam04352
321314005819	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
321314005820	GAF domain; Region: GAF_2; pfam13185
321314005821	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
321314005822	Paraquat-inducible protein A; Region: PqiA; pfam04403
321314005823	Paraquat-inducible protein A; Region: PqiA; pfam04403
321314005824	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
321314005825	mce related protein; Region: MCE; pfam02470
321314005826	mce related protein; Region: MCE; pfam02470
321314005827	mce related protein; Region: MCE; pfam02470
321314005828	mce related protein; Region: MCE; pfam02470
321314005829	mce related protein; Region: MCE; pfam02470
321314005830	mce related protein; Region: MCE; pfam02470
321314005831	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
321314005832	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
321314005833	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
321314005834	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
321314005835	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
321314005836	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
321314005837	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
321314005838	type III secretion protein SopE2; Provisional; Region: PRK15280
321314005839	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
321314005840	SopE GEF domain; Region: SopE_GEF; pfam07487
321314005841	Protein of unknown function (DUF1398); Region: DUF1398; pfam07166
321314005842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314005843	Coenzyme A binding pocket [chemical binding]; other site
321314005844	similar to IS285
321314005845	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
321314005846	similar to IS285
321314005847	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
321314005848	DNA binding site [nucleotide binding]
321314005849	active site
321314005850	Int/Topo IB signature motif; other site
321314005851	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
321314005852	Fimbrial protein; Region: Fimbrial; cl01416
321314005853	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
321314005854	EamA-like transporter family; Region: EamA; pfam00892
321314005855	EamA-like transporter family; Region: EamA; pfam00892
321314005856	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
321314005857	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
321314005858	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
321314005859	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
321314005860	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314005861	metal binding site [ion binding]; metal-binding site
321314005862	active site
321314005863	I-site; other site
321314005864	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
321314005865	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
321314005866	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
321314005867	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
321314005868	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
321314005869	dimer interface [polypeptide binding]; other site
321314005870	active site
321314005871	Int/Topo IB signature motif; other site
321314005872	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
321314005873	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
321314005874	hypothetical protein; Provisional; Region: PRK10301
321314005875	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
321314005876	Predicted amidohydrolase [General function prediction only]; Region: COG0388
321314005877	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
321314005878	exodeoxyribonuclease X; Provisional; Region: PRK07983
321314005879	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
321314005880	active site
321314005881	catalytic site [active]
321314005882	substrate binding site [chemical binding]; other site
321314005883	protease 2; Provisional; Region: PRK10115
321314005884	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
321314005885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
321314005886	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
321314005887	putative metal binding site [ion binding]; other site
321314005888	hypothetical protein; Provisional; Region: PRK13680
321314005889	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
321314005890	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
321314005891	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
321314005892	ATP-grasp domain; Region: ATP-grasp; pfam02222
321314005893	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
321314005894	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
321314005895	active site
321314005896	intersubunit interface [polypeptide binding]; other site
321314005897	catalytic residue [active]
321314005898	Dehydratase family; Region: ILVD_EDD; cl00340
321314005899	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
321314005900	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
321314005901	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
321314005902	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
321314005903	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
321314005904	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
321314005905	putative active site [active]
321314005906	pyruvate kinase; Provisional; Region: PRK05826
321314005907	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
321314005908	domain interfaces; other site
321314005909	active site
321314005910	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314005911	Integrase core domain; Region: rve; pfam00665
321314005912	Integrase core domain; Region: rve_3; pfam13683
321314005913	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
321314005914	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
321314005915	putative acyl-acceptor binding pocket; other site
321314005916	putative peptidase; Provisional; Region: PRK11649
321314005917	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
321314005918	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314005919	Peptidase family M23; Region: Peptidase_M23; pfam01551
321314005920	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
321314005921	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
321314005922	metal binding site [ion binding]; metal-binding site
321314005923	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
321314005924	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
321314005925	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
321314005926	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314005927	ABC-ATPase subunit  interface; other site
321314005928	dimer interface [polypeptide binding]; other site
321314005929	putative PBP binding regions; other site
321314005930	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
321314005931	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314005932	Walker A motif; other site
321314005933	ATP binding site [chemical binding]; other site
321314005934	Walker B motif; other site
321314005935	arginine finger; other site
321314005936	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
321314005937	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
321314005938	RuvA N terminal domain; Region: RuvA_N; pfam01330
321314005939	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
321314005940	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
321314005941	active site
321314005942	putative DNA-binding cleft [nucleotide binding]; other site
321314005943	dimer interface [polypeptide binding]; other site
321314005944	hypothetical protein; Validated; Region: PRK00110
321314005945	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
321314005946	nudix motif; other site
321314005947	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
321314005948	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
321314005949	dimer interface [polypeptide binding]; other site
321314005950	anticodon binding site; other site
321314005951	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
321314005952	homodimer interface [polypeptide binding]; other site
321314005953	motif 1; other site
321314005954	active site
321314005955	motif 2; other site
321314005956	GAD domain; Region: GAD; pfam02938
321314005957	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
321314005958	active site
321314005959	motif 3; other site
321314005960	Isochorismatase family; Region: Isochorismatase; pfam00857
321314005961	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
321314005962	catalytic triad [active]
321314005963	conserved cis-peptide bond; other site
321314005964	hypothetical protein; Provisional; Region: PRK10302
321314005965	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
321314005966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314005967	S-adenosylmethionine binding site [chemical binding]; other site
321314005968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314005969	S-adenosylmethionine binding site [chemical binding]; other site
321314005970	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
321314005971	putative metal binding site [ion binding]; other site
321314005972	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
321314005973	arginyl-tRNA synthetase; Region: argS; TIGR00456
321314005974	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
321314005975	active site
321314005976	HIGH motif; other site
321314005977	KMSK motif region; other site
321314005978	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
321314005979	tRNA binding surface [nucleotide binding]; other site
321314005980	anticodon binding site; other site
321314005981	penicillin-binding protein 2; Provisional; Region: PRK10795
321314005982	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
321314005983	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
321314005984	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
321314005985	Flagellar protein FlhE; Region: FlhE; pfam06366
321314005986	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
321314005987	FHIPEP family; Region: FHIPEP; pfam00771
321314005988	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
321314005989	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
321314005990	chemotaxis regulator CheZ; Provisional; Region: PRK11166
321314005991	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
321314005992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314005993	active site
321314005994	phosphorylation site [posttranslational modification]
321314005995	intermolecular recognition site; other site
321314005996	dimerization interface [polypeptide binding]; other site
321314005997	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
321314005998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314005999	active site
321314006000	phosphorylation site [posttranslational modification]
321314006001	intermolecular recognition site; other site
321314006002	dimerization interface [polypeptide binding]; other site
321314006003	CheB methylesterase; Region: CheB_methylest; pfam01339
321314006004	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
321314006005	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
321314006006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314006007	S-adenosylmethionine binding site [chemical binding]; other site
321314006008	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
321314006009	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
321314006010	dimer interface [polypeptide binding]; other site
321314006011	ligand binding site [chemical binding]; other site
321314006012	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314006013	dimerization interface [polypeptide binding]; other site
321314006014	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314006015	dimer interface [polypeptide binding]; other site
321314006016	putative CheW interface [polypeptide binding]; other site
321314006017	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
321314006018	putative CheA interaction surface; other site
321314006019	chemotaxis protein CheA; Provisional; Region: PRK10547
321314006020	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
321314006021	putative binding surface; other site
321314006022	active site
321314006023	CheY binding; Region: CheY-binding; pfam09078
321314006024	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
321314006025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314006026	ATP binding site [chemical binding]; other site
321314006027	Mg2+ binding site [ion binding]; other site
321314006028	G-X-G motif; other site
321314006029	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
321314006030	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
321314006031	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
321314006032	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
321314006033	ligand binding site [chemical binding]; other site
321314006034	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
321314006035	flagellar motor protein MotA; Validated; Region: PRK09110
321314006036	transcriptional activator FlhC; Provisional; Region: PRK12722
321314006037	transcriptional activator FlhD; Provisional; Region: PRK02909
321314006038	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
321314006039	Ligand Binding Site [chemical binding]; other site
321314006040	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
321314006041	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
321314006042	active site
321314006043	homotetramer interface [polypeptide binding]; other site
321314006044	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
321314006045	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
321314006046	DJ-1 family protein; Region: not_thiJ; TIGR01383
321314006047	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
321314006048	conserved cys residue [active]
321314006049	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
321314006050	Ferritin-like domain; Region: Ferritin; pfam00210
321314006051	ferroxidase diiron center [ion binding]; other site
321314006052	hypothetical protein; Provisional; Region: PRK09273
321314006053	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
321314006054	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
321314006055	YecR-like lipoprotein; Region: YecR; pfam13992
321314006056	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
321314006057	Ferritin-like domain; Region: Ferritin; pfam00210
321314006058	ferroxidase diiron center [ion binding]; other site
321314006059	probable metal-binding protein; Region: matur_matur; TIGR03853
321314006060	tyrosine transporter TyrP; Provisional; Region: PRK15132
321314006061	aromatic amino acid transport protein; Region: araaP; TIGR00837
321314006062	hypothetical protein; Provisional; Region: PRK10396
321314006063	yecA family protein; Region: ygfB_yecA; TIGR02292
321314006064	SEC-C motif; Region: SEC-C; pfam02810
321314006065	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
321314006066	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
321314006067	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
321314006068	GIY-YIG motif/motif A; other site
321314006069	active site
321314006070	catalytic site [active]
321314006071	putative DNA binding site [nucleotide binding]; other site
321314006072	metal binding site [ion binding]; metal-binding site
321314006073	UvrB/uvrC motif; Region: UVR; pfam02151
321314006074	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
321314006075	Helix-hairpin-helix motif; Region: HHH; pfam00633
321314006076	response regulator; Provisional; Region: PRK09483
321314006077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314006078	active site
321314006079	phosphorylation site [posttranslational modification]
321314006080	intermolecular recognition site; other site
321314006081	dimerization interface [polypeptide binding]; other site
321314006082	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314006083	DNA binding residues [nucleotide binding]
321314006084	dimerization interface [polypeptide binding]; other site
321314006085	hypothetical protein; Provisional; Region: PRK10613
321314006086	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
321314006087	Autoinducer binding domain; Region: Autoind_bind; pfam03472
321314006088	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314006089	DNA binding residues [nucleotide binding]
321314006090	dimerization interface [polypeptide binding]; other site
321314006091	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
321314006092	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
321314006093	Walker A/P-loop; other site
321314006094	ATP binding site [chemical binding]; other site
321314006095	Q-loop/lid; other site
321314006096	ABC transporter signature motif; other site
321314006097	Walker B; other site
321314006098	D-loop; other site
321314006099	H-loop/switch region; other site
321314006100	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
321314006101	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314006102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314006103	dimer interface [polypeptide binding]; other site
321314006104	conserved gate region; other site
321314006105	putative PBP binding loops; other site
321314006106	ABC-ATPase subunit interface; other site
321314006107	D-cysteine desulfhydrase; Validated; Region: PRK03910
321314006108	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
321314006109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314006110	catalytic residue [active]
321314006111	cystine transporter subunit; Provisional; Region: PRK11260
321314006112	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314006113	substrate binding pocket [chemical binding]; other site
321314006114	membrane-bound complex binding site; other site
321314006115	hinge residues; other site
321314006116	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
321314006117	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
321314006118	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
321314006119	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
321314006120	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
321314006121	DNA binding residues [nucleotide binding]
321314006122	similar to IS200
321314006123	similar to IS200
321314006124	flagellin; Validated; Region: PRK08026
321314006125	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
321314006126	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
321314006127	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
321314006128	flagellar capping protein; Reviewed; Region: fliD; PRK08032
321314006129	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
321314006130	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
321314006131	flagellar protein FliS; Validated; Region: fliS; PRK05685
321314006132	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
321314006133	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
321314006134	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
321314006135	active site
321314006136	Na/Ca binding site [ion binding]; other site
321314006137	catalytic site [active]
321314006138	lipoprotein; Provisional; Region: PRK10397
321314006139	putative inner membrane protein; Provisional; Region: PRK11099
321314006140	Sulphur transport; Region: Sulf_transp; pfam04143
321314006141	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
321314006142	CPxP  motif; other site
321314006143	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
321314006144	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
321314006145	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
321314006146	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
321314006147	flagellar motor switch protein FliG; Region: fliG; TIGR00207
321314006148	FliG C-terminal domain; Region: FliG_C; pfam01706
321314006149	flagellar assembly protein H; Validated; Region: fliH; PRK05687
321314006150	Flagellar assembly protein FliH; Region: FliH; pfam02108
321314006151	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
321314006152	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
321314006153	Walker A motif/ATP binding site; other site
321314006154	Walker B motif; other site
321314006155	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
321314006156	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
321314006157	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
321314006158	flagellar hook-length control protein; Provisional; Region: PRK10118
321314006159	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
321314006160	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
321314006161	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
321314006162	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
321314006163	flagellar motor switch protein; Validated; Region: fliN; PRK05698
321314006164	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
321314006165	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
321314006166	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
321314006167	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
321314006168	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
321314006169	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314006170	DNA binding residues [nucleotide binding]
321314006171	dimerization interface [polypeptide binding]; other site
321314006172	hypothetical protein; Provisional; Region: PRK10708
321314006173	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
321314006174	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
321314006175	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314006176	active site
321314006177	motif I; other site
321314006178	motif II; other site
321314006179	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
321314006180	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314006181	metal binding site [ion binding]; metal-binding site
321314006182	active site
321314006183	I-site; other site
321314006184	Uncharacterized small protein [Function unknown]; Region: COG5475
321314006185	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
321314006186	EamA-like transporter family; Region: EamA; pfam00892
321314006187	EamA-like transporter family; Region: EamA; pfam00892
321314006188	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
321314006189	additional DNA contacts [nucleotide binding]; other site
321314006190	mismatch recognition site; other site
321314006191	active site
321314006192	zinc binding site [ion binding]; other site
321314006193	DNA intercalation site [nucleotide binding]; other site
321314006194	DNA cytosine methylase; Provisional; Region: PRK10458
321314006195	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
321314006196	cofactor binding site; other site
321314006197	DNA binding site [nucleotide binding]
321314006198	substrate interaction site [chemical binding]; other site
321314006199	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
321314006200	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
321314006201	Zn2+ binding site [ion binding]; other site
321314006202	Mg2+ binding site [ion binding]; other site
321314006203	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314006204	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
321314006205	trimer interface [polypeptide binding]; other site
321314006206	eyelet of channel; other site
321314006207	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
321314006208	DNA-binding site [nucleotide binding]; DNA binding site
321314006209	RNA-binding motif; other site
321314006210	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
321314006211	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
321314006212	active site
321314006213	DNA binding site [nucleotide binding]
321314006214	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
321314006215	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
321314006216	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
321314006217	Catalytic site [active]
321314006218	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
321314006219	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
321314006220	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
321314006221	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
321314006222	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
321314006223	Integrase; Region: Integrase_1; pfam12835
321314006224	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
321314006225	DDE superfamily endonuclease; Region: DDE_3; pfam13358
321314006226	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
321314006227	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314006228	Sel1-like repeats; Region: SEL1; smart00671
321314006229	Sel1-like repeats; Region: SEL1; smart00671
321314006230	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723
321314006231	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706
321314006232	AMP nucleosidase; Provisional; Region: PRK08292
321314006233	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
321314006234	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
321314006235	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
321314006236	similar to hypothetical protein
321314006237	MATE family multidrug exporter; Provisional; Region: PRK10189
321314006238	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
321314006239	L,D-transpeptidase; Provisional; Region: PRK10190
321314006240	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
321314006241	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
321314006242	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
321314006243	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
321314006244	putative dimer interface [polypeptide binding]; other site
321314006245	active site pocket [active]
321314006246	putative cataytic base [active]
321314006247	cobalamin synthase; Reviewed; Region: cobS; PRK00235
321314006248	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
321314006249	homotrimer interface [polypeptide binding]; other site
321314006250	Walker A motif; other site
321314006251	GTP binding site [chemical binding]; other site
321314006252	Walker B motif; other site
321314006253	cobyric acid synthase; Provisional; Region: PRK00784
321314006254	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
321314006255	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
321314006256	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
321314006257	catalytic triad [active]
321314006258	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
321314006259	Q-loop/lid; other site
321314006260	ABC transporter signature motif; other site
321314006261	Walker B; other site
321314006262	D-loop; other site
321314006263	H-loop/switch region; other site
321314006264	cobalt transport protein CbiQ; Provisional; Region: PRK15485
321314006265	cobalt transport protein CbiN; Provisional; Region: PRK02898
321314006266	cobalt transport protein CbiM; Validated; Region: PRK08319
321314006267	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
321314006268	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
321314006269	active site
321314006270	SAM binding site [chemical binding]; other site
321314006271	homodimer interface [polypeptide binding]; other site
321314006272	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
321314006273	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
321314006274	active site
321314006275	C-terminal domain interface [polypeptide binding]; other site
321314006276	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
321314006277	active site
321314006278	N-terminal domain interface [polypeptide binding]; other site
321314006279	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
321314006280	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
321314006281	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
321314006282	active site
321314006283	SAM binding site [chemical binding]; other site
321314006284	homodimer interface [polypeptide binding]; other site
321314006285	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
321314006286	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
321314006287	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
321314006288	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
321314006289	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
321314006290	active site
321314006291	SAM binding site [chemical binding]; other site
321314006292	homodimer interface [polypeptide binding]; other site
321314006293	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
321314006294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314006295	S-adenosylmethionine binding site [chemical binding]; other site
321314006296	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
321314006297	active site
321314006298	putative homodimer interface [polypeptide binding]; other site
321314006299	SAM binding site [chemical binding]; other site
321314006300	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
321314006301	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
321314006302	Precorrin-8X methylmutase; Region: CbiC; pfam02570
321314006303	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
321314006304	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
321314006305	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
321314006306	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
321314006307	catalytic triad [active]
321314006308	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
321314006309	Sensory domain found in PocR; Region: PocR; pfam10114
321314006310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314006311	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314006312	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314006313	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
321314006314	amphipathic channel; other site
321314006315	Asn-Pro-Ala signature motifs; other site
321314006316	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
321314006317	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
321314006318	Hexamer interface [polypeptide binding]; other site
321314006319	Putative hexagonal pore residue; other site
321314006320	propanediol utilization protein PduB; Provisional; Region: PRK15415
321314006321	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
321314006322	putative hexamer interface [polypeptide binding]; other site
321314006323	putative hexagonal pore; other site
321314006324	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
321314006325	putative hexamer interface [polypeptide binding]; other site
321314006326	putative hexagonal pore; other site
321314006327	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
321314006328	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
321314006329	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
321314006330	alpha-beta subunit interface [polypeptide binding]; other site
321314006331	alpha-gamma subunit interface [polypeptide binding]; other site
321314006332	active site
321314006333	substrate and K+ binding site; other site
321314006334	K+ binding site [ion binding]; other site
321314006335	cobalamin binding site [chemical binding]; other site
321314006336	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
321314006337	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
321314006338	Cell division protein FtsA; Region: FtsA; cl17206
321314006339	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
321314006340	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
321314006341	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
321314006342	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
321314006343	Hexamer interface [polypeptide binding]; other site
321314006344	Putative hexagonal pore residue; other site
321314006345	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
321314006346	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
321314006347	putative hexamer interface [polypeptide binding]; other site
321314006348	putative hexagonal pore; other site
321314006349	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
321314006350	Propanediol utilisation protein PduL; Region: PduL; pfam06130
321314006351	Propanediol utilisation protein PduL; Region: PduL; pfam06130
321314006352	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
321314006353	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
321314006354	Hexamer/Pentamer interface [polypeptide binding]; other site
321314006355	central pore; other site
321314006356	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
321314006357	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
321314006358	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
321314006359	putative catalytic cysteine [active]
321314006360	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
321314006361	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
321314006362	putative active site [active]
321314006363	metal binding site [ion binding]; metal-binding site
321314006364	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
321314006365	SLBB domain; Region: SLBB; pfam10531
321314006366	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
321314006367	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
321314006368	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
321314006369	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
321314006370	putative hexamer interface [polypeptide binding]; other site
321314006371	putative hexagonal pore; other site
321314006372	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
321314006373	Hexagonal pore residue; other site
321314006374	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
321314006375	G3 box; other site
321314006376	Switch II region; other site
321314006377	GTP/Mg2+ binding site [chemical binding]; other site
321314006378	G4 box; other site
321314006379	G5 box; other site
321314006380	propionate kinase; Reviewed; Region: PRK12397
321314006381	propionate/acetate kinase; Provisional; Region: PRK12379
321314006382	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
321314006383	hypothetical protein; Provisional; Region: PRK05423
321314006384	Predicted membrane protein [Function unknown]; Region: COG1289
321314006385	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
321314006386	DNA gyrase inhibitor; Provisional; Region: PRK10016
321314006387	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
321314006388	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
321314006389	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
321314006390	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
321314006391	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
321314006392	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
321314006393	4Fe-4S binding domain; Region: Fer4; cl02805
321314006394	thiosulfate reductase PhsA; Provisional; Region: PRK15488
321314006395	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
321314006396	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
321314006397	putative [Fe4-S4] binding site [ion binding]; other site
321314006398	putative molybdopterin cofactor binding site [chemical binding]; other site
321314006399	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
321314006400	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
321314006401	putative molybdopterin cofactor binding site; other site
321314006402	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
321314006403	SopA-like central domain; Region: SopA; pfam13981
321314006404	SopA-like catalytic domain; Region: SopA_C; pfam13979
321314006405	exonuclease I; Provisional; Region: sbcB; PRK11779
321314006406	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
321314006407	active site
321314006408	catalytic site [active]
321314006409	substrate binding site [chemical binding]; other site
321314006410	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
321314006411	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
321314006412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314006413	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
321314006414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314006415	dimerization interface [polypeptide binding]; other site
321314006416	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
321314006417	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
321314006418	putative NAD(P) binding site [chemical binding]; other site
321314006419	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
321314006420	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
321314006421	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
321314006422	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
321314006423	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
321314006424	NAD binding site [chemical binding]; other site
321314006425	dimerization interface [polypeptide binding]; other site
321314006426	product binding site; other site
321314006427	substrate binding site [chemical binding]; other site
321314006428	zinc binding site [ion binding]; other site
321314006429	catalytic residues [active]
321314006430	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
321314006431	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314006432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314006433	homodimer interface [polypeptide binding]; other site
321314006434	catalytic residue [active]
321314006435	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
321314006436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314006437	active site
321314006438	motif I; other site
321314006439	motif II; other site
321314006440	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
321314006441	putative active site pocket [active]
321314006442	4-fold oligomerization interface [polypeptide binding]; other site
321314006443	metal binding residues [ion binding]; metal-binding site
321314006444	3-fold/trimer interface [polypeptide binding]; other site
321314006445	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
321314006446	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
321314006447	putative active site [active]
321314006448	oxyanion strand; other site
321314006449	catalytic triad [active]
321314006450	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
321314006451	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
321314006452	catalytic residues [active]
321314006453	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
321314006454	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
321314006455	substrate binding site [chemical binding]; other site
321314006456	glutamase interaction surface [polypeptide binding]; other site
321314006457	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
321314006458	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
321314006459	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
321314006460	metal binding site [ion binding]; metal-binding site
321314006461	chain length determinant protein WzzB; Provisional; Region: PRK15471
321314006462	Chain length determinant protein; Region: Wzz; cl15801
321314006463	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
321314006464	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
321314006465	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
321314006466	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
321314006467	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
321314006468	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
321314006469	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
321314006470	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
321314006471	phosphomannomutase CpsG; Provisional; Region: PRK15414
321314006472	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
321314006473	active site
321314006474	substrate binding site [chemical binding]; other site
321314006475	metal binding site [ion binding]; metal-binding site
321314006476	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
321314006477	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
321314006478	Substrate binding site; other site
321314006479	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
321314006480	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
321314006481	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
321314006482	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
321314006483	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
321314006484	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
321314006485	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
321314006486	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
321314006487	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
321314006488	active site
321314006489	tetramer interface; other site
321314006490	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
321314006491	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
321314006492	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
321314006493	putative ADP-binding pocket [chemical binding]; other site
321314006494	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
321314006495	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
321314006496	colanic acid exporter; Provisional; Region: PRK10459
321314006497	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
321314006498	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
321314006499	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
321314006500	phosphomannomutase CpsG; Provisional; Region: PRK15414
321314006501	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
321314006502	active site
321314006503	substrate binding site [chemical binding]; other site
321314006504	metal binding site [ion binding]; metal-binding site
321314006505	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
321314006506	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
321314006507	Substrate binding site; other site
321314006508	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
321314006509	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
321314006510	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
321314006511	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
321314006512	active site
321314006513	GDP-Mannose binding site [chemical binding]; other site
321314006514	dimer interface [polypeptide binding]; other site
321314006515	modified nudix motif
321314006516	metal binding site [ion binding]; metal-binding site
321314006517	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
321314006518	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
321314006519	NADP binding site [chemical binding]; other site
321314006520	active site
321314006521	putative substrate binding site [chemical binding]; other site
321314006522	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
321314006523	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
321314006524	NADP-binding site; other site
321314006525	homotetramer interface [polypeptide binding]; other site
321314006526	substrate binding site [chemical binding]; other site
321314006527	homodimer interface [polypeptide binding]; other site
321314006528	active site
321314006529	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
321314006530	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
321314006531	putative trimer interface [polypeptide binding]; other site
321314006532	putative active site [active]
321314006533	putative substrate binding site [chemical binding]; other site
321314006534	putative CoA binding site [chemical binding]; other site
321314006535	putative glycosyl transferase; Provisional; Region: PRK10063
321314006536	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
321314006537	metal-binding site
321314006538	putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010
321314006539	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
321314006540	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
321314006541	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
321314006542	putative acyl transferase; Provisional; Region: PRK10191
321314006543	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
321314006544	trimer interface [polypeptide binding]; other site
321314006545	active site
321314006546	substrate binding site [chemical binding]; other site
321314006547	CoA binding site [chemical binding]; other site
321314006548	putative glycosyl transferase; Provisional; Region: PRK10018
321314006549	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
321314006550	active site
321314006551	tyrosine kinase; Provisional; Region: PRK11519
321314006552	Chain length determinant protein; Region: Wzz; pfam02706
321314006553	Chain length determinant protein; Region: Wzz; cl15801
321314006554	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
321314006555	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
321314006556	Low molecular weight phosphatase family; Region: LMWPc; cd00115
321314006557	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
321314006558	active site
321314006559	polysaccharide export protein Wza; Provisional; Region: PRK15078
321314006560	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
321314006561	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
321314006562	FOG: CBS domain [General function prediction only]; Region: COG0517
321314006563	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
321314006564	Transporter associated domain; Region: CorC_HlyC; smart01091
321314006565	putative assembly protein; Provisional; Region: PRK10833
321314006566	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
321314006567	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
321314006568	trimer interface [polypeptide binding]; other site
321314006569	active site
321314006570	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
321314006571	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
321314006572	ATP-binding site [chemical binding]; other site
321314006573	Sugar specificity; other site
321314006574	Pyrimidine base specificity; other site
321314006575	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
321314006576	PAS domain S-box; Region: sensory_box; TIGR00229
321314006577	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314006578	putative active site [active]
321314006579	heme pocket [chemical binding]; other site
321314006580	PAS domain S-box; Region: sensory_box; TIGR00229
321314006581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314006582	putative active site [active]
321314006583	heme pocket [chemical binding]; other site
321314006584	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
321314006585	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314006586	metal binding site [ion binding]; metal-binding site
321314006587	active site
321314006588	I-site; other site
321314006589	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314006590	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
321314006591	AlkA N-terminal domain; Region: AlkA_N; pfam06029
321314006592	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
321314006593	minor groove reading motif; other site
321314006594	helix-hairpin-helix signature motif; other site
321314006595	substrate binding pocket [chemical binding]; other site
321314006596	active site
321314006597	putative chaperone; Provisional; Region: PRK11678
321314006598	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
321314006599	nucleotide binding site [chemical binding]; other site
321314006600	putative NEF/HSP70 interaction site [polypeptide binding]; other site
321314006601	SBD interface [polypeptide binding]; other site
321314006602	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
321314006603	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314006604	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314006605	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
321314006606	Protein export membrane protein; Region: SecD_SecF; cl14618
321314006607	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
321314006608	Protein export membrane protein; Region: SecD_SecF; cl14618
321314006609	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
321314006610	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314006611	dimerization interface [polypeptide binding]; other site
321314006612	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314006613	dimer interface [polypeptide binding]; other site
321314006614	phosphorylation site [posttranslational modification]
321314006615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314006616	ATP binding site [chemical binding]; other site
321314006617	Mg2+ binding site [ion binding]; other site
321314006618	G-X-G motif; other site
321314006619	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
321314006620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314006621	active site
321314006622	phosphorylation site [posttranslational modification]
321314006623	intermolecular recognition site; other site
321314006624	dimerization interface [polypeptide binding]; other site
321314006625	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314006626	DNA binding site [nucleotide binding]
321314006627	PcfJ-like protein; Region: PcfJ; pfam14284
321314006628	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
321314006629	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
321314006630	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
321314006631	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
321314006632	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314006633	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314006634	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
321314006635	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
321314006636	putative protease; Provisional; Region: PRK15452
321314006637	Peptidase family U32; Region: Peptidase_U32; pfam01136
321314006638	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
321314006639	lipid kinase; Reviewed; Region: PRK13054
321314006640	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
321314006641	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
321314006642	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
321314006643	putative active site; other site
321314006644	catalytic residue [active]
321314006645	nucleoside transporter; Region: 2A0110; TIGR00889
321314006646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314006647	putative substrate translocation pore; other site
321314006648	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
321314006649	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314006650	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
321314006651	substrate binding site [chemical binding]; other site
321314006652	ATP binding site [chemical binding]; other site
321314006653	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
321314006654	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314006655	DNA-binding site [nucleotide binding]; DNA binding site
321314006656	UTRA domain; Region: UTRA; pfam07702
321314006657	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
321314006658	dimer interface [polypeptide binding]; other site
321314006659	substrate binding site [chemical binding]; other site
321314006660	ATP binding site [chemical binding]; other site
321314006661	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
321314006662	substrate binding site [chemical binding]; other site
321314006663	multimerization interface [polypeptide binding]; other site
321314006664	ATP binding site [chemical binding]; other site
321314006665	Predicted integral membrane protein [Function unknown]; Region: COG5455
321314006666	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
321314006667	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
321314006668	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
321314006669	PapC N-terminal domain; Region: PapC_N; pfam13954
321314006670	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314006671	PapC C-terminal domain; Region: PapC_C; pfam13953
321314006672	putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253
321314006673	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314006674	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314006675	fimbrial chaperone protein; Provisional; Region: PRK15220
321314006676	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
321314006677	antiporter inner membrane protein; Provisional; Region: PRK11670
321314006678	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
321314006679	Walker A motif; other site
321314006680	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
321314006681	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
321314006682	active site
321314006683	HIGH motif; other site
321314006684	KMSKS motif; other site
321314006685	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
321314006686	tRNA binding surface [nucleotide binding]; other site
321314006687	anticodon binding site; other site
321314006688	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
321314006689	dimer interface [polypeptide binding]; other site
321314006690	putative tRNA-binding site [nucleotide binding]; other site
321314006691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
321314006692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
321314006693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
321314006694	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
321314006695	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
321314006696	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
321314006697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314006698	active site
321314006699	phosphorylation site [posttranslational modification]
321314006700	intermolecular recognition site; other site
321314006701	dimerization interface [polypeptide binding]; other site
321314006702	LytTr DNA-binding domain; Region: LytTR; pfam04397
321314006703	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
321314006704	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
321314006705	GAF domain; Region: GAF; pfam01590
321314006706	Histidine kinase; Region: His_kinase; pfam06580
321314006707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314006708	ATP binding site [chemical binding]; other site
321314006709	Mg2+ binding site [ion binding]; other site
321314006710	G-X-G motif; other site
321314006711	transcriptional regulator MirA; Provisional; Region: PRK15043
321314006712	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
321314006713	DNA binding residues [nucleotide binding]
321314006714	hypothetical protein; Provisional; Region: PRK13681
321314006715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314006716	putative PBP binding loops; other site
321314006717	ABC-ATPase subunit interface; other site
321314006718	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
321314006719	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
321314006720	Walker A/P-loop; other site
321314006721	ATP binding site [chemical binding]; other site
321314006722	Q-loop/lid; other site
321314006723	ABC transporter signature motif; other site
321314006724	Walker B; other site
321314006725	D-loop; other site
321314006726	H-loop/switch region; other site
321314006727	CBS domain; Region: CBS; pfam00571
321314006728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314006729	dimer interface [polypeptide binding]; other site
321314006730	conserved gate region; other site
321314006731	ABC-ATPase subunit interface; other site
321314006732	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
321314006733	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
321314006734	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
321314006735	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
321314006736	D-lactate dehydrogenase; Provisional; Region: PRK11183
321314006737	FAD binding domain; Region: FAD_binding_4; pfam01565
321314006738	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
321314006739	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
321314006740	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
321314006741	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
321314006742	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
321314006743	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
321314006744	oxidoreductase; Provisional; Region: PRK12743
321314006745	classical (c) SDRs; Region: SDR_c; cd05233
321314006746	NAD(P) binding site [chemical binding]; other site
321314006747	active site
321314006748	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
321314006749	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
321314006750	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
321314006751	FMN binding site [chemical binding]; other site
321314006752	active site
321314006753	catalytic residues [active]
321314006754	substrate binding site [chemical binding]; other site
321314006755	salicylate hydroxylase; Provisional; Region: PRK08163
321314006756	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
321314006757	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
321314006758	maleylacetoacetate isomerase; Region: maiA; TIGR01262
321314006759	C-terminal domain interface [polypeptide binding]; other site
321314006760	GSH binding site (G-site) [chemical binding]; other site
321314006761	putative dimer interface [polypeptide binding]; other site
321314006762	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
321314006763	dimer interface [polypeptide binding]; other site
321314006764	N-terminal domain interface [polypeptide binding]; other site
321314006765	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
321314006766	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
321314006767	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
321314006768	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
321314006769	Cupin domain; Region: Cupin_2; pfam07883
321314006770	Cupin domain; Region: Cupin_2; pfam07883
321314006771	benzoate transport; Region: 2A0115; TIGR00895
321314006772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314006773	putative substrate translocation pore; other site
321314006774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314006775	putative substrate translocation pore; other site
321314006776	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
321314006777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314006778	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314006779	dimerization interface [polypeptide binding]; other site
321314006780	hypothetical protein; Provisional; Region: PRK01821
321314006781	hypothetical protein; Provisional; Region: PRK10711
321314006782	cytidine deaminase; Provisional; Region: PRK09027
321314006783	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
321314006784	active site
321314006785	catalytic motif [active]
321314006786	Zn binding site [ion binding]; other site
321314006787	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
321314006788	active site
321314006789	catalytic motif [active]
321314006790	Zn binding site [ion binding]; other site
321314006791	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
321314006792	putative active site [active]
321314006793	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
321314006794	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
321314006795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
321314006796	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314006797	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
321314006798	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
321314006799	homodimer interface [polypeptide binding]; other site
321314006800	active site
321314006801	FMN binding site [chemical binding]; other site
321314006802	substrate binding site [chemical binding]; other site
321314006803	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
321314006804	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
321314006805	TM-ABC transporter signature motif; other site
321314006806	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
321314006807	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
321314006808	ligand binding site [chemical binding]; other site
321314006809	calcium binding site [ion binding]; other site
321314006810	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
321314006811	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314006812	DNA binding site [nucleotide binding]
321314006813	domain linker motif; other site
321314006814	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
321314006815	dimerization interface (closed form) [polypeptide binding]; other site
321314006816	ligand binding site [chemical binding]; other site
321314006817	Predicted membrane protein [Function unknown]; Region: COG2311
321314006818	hypothetical protein; Provisional; Region: PRK10835
321314006819	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
321314006820	GTP cyclohydrolase I; Provisional; Region: PLN03044
321314006821	active site
321314006822	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314006823	non-specific DNA binding site [nucleotide binding]; other site
321314006824	salt bridge; other site
321314006825	sequence-specific DNA binding site [nucleotide binding]; other site
321314006826	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
321314006827	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
321314006828	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
321314006829	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
321314006830	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
321314006831	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314006832	motif II; other site
321314006833	regulatory protein UhpC; Provisional; Region: PRK11663
321314006834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314006835	putative substrate translocation pore; other site
321314006836	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
321314006837	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314006838	N-terminal plug; other site
321314006839	ligand-binding site [chemical binding]; other site
321314006840	lysine transporter; Provisional; Region: PRK10836
321314006841	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
321314006842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314006843	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
321314006844	putative dimerization interface [polypeptide binding]; other site
321314006845	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
321314006846	endonuclease IV; Provisional; Region: PRK01060
321314006847	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
321314006848	AP (apurinic/apyrimidinic) site pocket; other site
321314006849	DNA interaction; other site
321314006850	Metal-binding active site; metal-binding site
321314006851	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
321314006852	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
321314006853	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
321314006854	active site
321314006855	P-loop; other site
321314006856	phosphorylation site [posttranslational modification]
321314006857	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
321314006858	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
321314006859	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
321314006860	putative substrate binding site [chemical binding]; other site
321314006861	putative ATP binding site [chemical binding]; other site
321314006862	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
321314006863	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314006864	active site
321314006865	phosphorylation site [posttranslational modification]
321314006866	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
321314006867	dimerization domain swap beta strand [polypeptide binding]; other site
321314006868	regulatory protein interface [polypeptide binding]; other site
321314006869	active site
321314006870	regulatory phosphorylation site [posttranslational modification]; other site
321314006871	sugar efflux transporter B; Provisional; Region: PRK15011
321314006872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314006873	putative substrate translocation pore; other site
321314006874	similar to Tn10
321314006875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
321314006876	chain length determinant protein WzzB; Provisional; Region: PRK15471
321314006877	elongation factor P; Provisional; Region: PRK04542
321314006878	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
321314006879	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
321314006880	RNA binding site [nucleotide binding]; other site
321314006881	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
321314006882	RNA binding site [nucleotide binding]; other site
321314006883	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
321314006884	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
321314006885	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
321314006886	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
321314006887	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
321314006888	active site
321314006889	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
321314006890	NlpC/P60 family; Region: NLPC_P60; pfam00877
321314006891	phage resistance protein; Provisional; Region: PRK10551
321314006892	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
321314006893	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314006894	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
321314006895	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
321314006896	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
321314006897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314006898	dimer interface [polypeptide binding]; other site
321314006899	conserved gate region; other site
321314006900	putative PBP binding loops; other site
321314006901	ABC-ATPase subunit interface; other site
321314006902	microcin C ABC transporter permease; Provisional; Region: PRK15021
321314006903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314006904	dimer interface [polypeptide binding]; other site
321314006905	conserved gate region; other site
321314006906	ABC-ATPase subunit interface; other site
321314006907	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
321314006908	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314006909	Walker A/P-loop; other site
321314006910	ATP binding site [chemical binding]; other site
321314006911	Q-loop/lid; other site
321314006912	ABC transporter signature motif; other site
321314006913	Walker B; other site
321314006914	D-loop; other site
321314006915	H-loop/switch region; other site
321314006916	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
321314006917	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314006918	Walker A/P-loop; other site
321314006919	ATP binding site [chemical binding]; other site
321314006920	Q-loop/lid; other site
321314006921	ABC transporter signature motif; other site
321314006922	Walker B; other site
321314006923	D-loop; other site
321314006924	H-loop/switch region; other site
321314006925	hypothetical protein; Provisional; Region: PRK11835
321314006926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314006927	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
321314006928	putative substrate translocation pore; other site
321314006929	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
321314006930	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314006931	RNA binding surface [nucleotide binding]; other site
321314006932	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
321314006933	active site
321314006934	uracil binding [chemical binding]; other site
321314006935	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
321314006936	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314006937	ATP binding site [chemical binding]; other site
321314006938	putative Mg++ binding site [ion binding]; other site
321314006939	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314006940	nucleotide binding region [chemical binding]; other site
321314006941	ATP-binding site [chemical binding]; other site
321314006942	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
321314006943	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
321314006944	5S rRNA interface [nucleotide binding]; other site
321314006945	CTC domain interface [polypeptide binding]; other site
321314006946	L16 interface [polypeptide binding]; other site
321314006947	Nucleoid-associated protein [General function prediction only]; Region: COG3081
321314006948	nucleoid-associated protein NdpA; Validated; Region: PRK00378
321314006949	hypothetical protein; Provisional; Region: PRK13689
321314006950	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
321314006951	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
321314006952	Sulfatase; Region: Sulfatase; cl17466
321314006953	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
321314006954	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
321314006955	DinI-like family; Region: DinI; cl11630
321314006956	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
321314006957	transcriptional regulator NarP; Provisional; Region: PRK10403
321314006958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314006959	active site
321314006960	phosphorylation site [posttranslational modification]
321314006961	intermolecular recognition site; other site
321314006962	dimerization interface [polypeptide binding]; other site
321314006963	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314006964	DNA binding residues [nucleotide binding]
321314006965	dimerization interface [polypeptide binding]; other site
321314006966	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
321314006967	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
321314006968	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
321314006969	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
321314006970	catalytic residues [active]
321314006971	central insert; other site
321314006972	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
321314006973	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
321314006974	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
321314006975	heme exporter protein CcmC; Region: ccmC; TIGR01191
321314006976	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
321314006977	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
321314006978	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314006979	Walker A/P-loop; other site
321314006980	ATP binding site [chemical binding]; other site
321314006981	Q-loop/lid; other site
321314006982	ABC transporter signature motif; other site
321314006983	Walker B; other site
321314006984	D-loop; other site
321314006985	H-loop/switch region; other site
321314006986	cytochrome c-type protein NapC; Provisional; Region: PRK10617
321314006987	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
321314006988	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
321314006989	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
321314006990	4Fe-4S binding domain; Region: Fer4_5; pfam12801
321314006991	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
321314006992	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
321314006993	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
321314006994	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
321314006995	[4Fe-4S] binding site [ion binding]; other site
321314006996	molybdopterin cofactor binding site; other site
321314006997	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
321314006998	molybdopterin cofactor binding site; other site
321314006999	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
321314007000	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
321314007001	secondary substrate binding site; other site
321314007002	primary substrate binding site; other site
321314007003	inhibition loop; other site
321314007004	dimerization interface [polypeptide binding]; other site
321314007005	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
321314007006	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
321314007007	Walker A/P-loop; other site
321314007008	ATP binding site [chemical binding]; other site
321314007009	Q-loop/lid; other site
321314007010	ABC transporter signature motif; other site
321314007011	Walker B; other site
321314007012	D-loop; other site
321314007013	H-loop/switch region; other site
321314007014	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
321314007015	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
321314007016	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
321314007017	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314007018	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
321314007019	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
321314007020	DNA binding site [nucleotide binding]
321314007021	active site
321314007022	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
321314007023	ApbE family; Region: ApbE; pfam02424
321314007024	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
321314007025	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
321314007026	trimer interface [polypeptide binding]; other site
321314007027	eyelet of channel; other site
321314007028	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
321314007029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314007030	ATP binding site [chemical binding]; other site
321314007031	Mg2+ binding site [ion binding]; other site
321314007032	G-X-G motif; other site
321314007033	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
321314007034	putative binding surface; other site
321314007035	active site
321314007036	transcriptional regulator RcsB; Provisional; Region: PRK10840
321314007037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314007038	active site
321314007039	phosphorylation site [posttranslational modification]
321314007040	intermolecular recognition site; other site
321314007041	dimerization interface [polypeptide binding]; other site
321314007042	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314007043	DNA binding residues [nucleotide binding]
321314007044	dimerization interface [polypeptide binding]; other site
321314007045	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
321314007046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314007047	dimer interface [polypeptide binding]; other site
321314007048	phosphorylation site [posttranslational modification]
321314007049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314007050	ATP binding site [chemical binding]; other site
321314007051	Mg2+ binding site [ion binding]; other site
321314007052	G-X-G motif; other site
321314007053	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
321314007054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314007055	active site
321314007056	phosphorylation site [posttranslational modification]
321314007057	intermolecular recognition site; other site
321314007058	dimerization interface [polypeptide binding]; other site
321314007059	DNA gyrase subunit A; Validated; Region: PRK05560
321314007060	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
321314007061	CAP-like domain; other site
321314007062	active site
321314007063	primary dimer interface [polypeptide binding]; other site
321314007064	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
321314007065	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
321314007066	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
321314007067	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
321314007068	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
321314007069	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
321314007070	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
321314007071	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
321314007072	active site pocket [active]
321314007073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007074	putative substrate translocation pore; other site
321314007075	Transcriptional regulators [Transcription]; Region: GntR; COG1802
321314007076	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314007077	DNA-binding site [nucleotide binding]; DNA binding site
321314007078	FCD domain; Region: FCD; pfam07729
321314007079	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
321314007080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314007081	S-adenosylmethionine binding site [chemical binding]; other site
321314007082	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
321314007083	ATP cone domain; Region: ATP-cone; pfam03477
321314007084	Class I ribonucleotide reductase; Region: RNR_I; cd01679
321314007085	active site
321314007086	dimer interface [polypeptide binding]; other site
321314007087	catalytic residues [active]
321314007088	effector binding site; other site
321314007089	R2 peptide binding site; other site
321314007090	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
321314007091	dimer interface [polypeptide binding]; other site
321314007092	putative radical transfer pathway; other site
321314007093	diiron center [ion binding]; other site
321314007094	tyrosyl radical; other site
321314007095	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
321314007096	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
321314007097	catalytic loop [active]
321314007098	iron binding site [ion binding]; other site
321314007099	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314007100	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007101	putative substrate translocation pore; other site
321314007102	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
321314007103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314007104	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
321314007105	dimerization interface [polypeptide binding]; other site
321314007106	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
321314007107	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
321314007108	active site
321314007109	catalytic site [active]
321314007110	metal binding site [ion binding]; metal-binding site
321314007111	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
321314007112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007113	putative substrate translocation pore; other site
321314007114	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
321314007115	hydroxyglutarate oxidase; Provisional; Region: PRK11728
321314007116	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
321314007117	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
321314007118	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
321314007119	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
321314007120	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
321314007121	Cysteine-rich domain; Region: CCG; pfam02754
321314007122	Cysteine-rich domain; Region: CCG; pfam02754
321314007123	deubiquitinase SseL; Provisional; Region: PRK14848
321314007124	hypothetical protein; Provisional; Region: PRK03673
321314007125	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
321314007126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007127	D-galactonate transporter; Region: 2A0114; TIGR00893
321314007128	putative substrate translocation pore; other site
321314007129	L-rhamnonate dehydratase; Provisional; Region: PRK15440
321314007130	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
321314007131	putative active site pocket [active]
321314007132	putative metal binding site [ion binding]; other site
321314007133	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
321314007134	Transcriptional regulator [Transcription]; Region: IclR; COG1414
321314007135	Bacterial transcriptional regulator; Region: IclR; pfam01614
321314007136	hypothetical protein; Provisional; Region: PRK03673
321314007137	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
321314007138	putative MPT binding site; other site
321314007139	Competence-damaged protein; Region: CinA; cl00666
321314007140	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
321314007141	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
321314007142	catalytic core [active]
321314007143	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
321314007144	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
321314007145	inhibitor-cofactor binding pocket; inhibition site
321314007146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314007147	catalytic residue [active]
321314007148	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
321314007149	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
321314007150	Ligand binding site; other site
321314007151	Putative Catalytic site; other site
321314007152	DXD motif; other site
321314007153	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
321314007154	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
321314007155	putative active site [active]
321314007156	putative catalytic site [active]
321314007157	putative Zn binding site [ion binding]; other site
321314007158	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
321314007159	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
321314007160	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
321314007161	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
321314007162	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
321314007163	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
321314007164	acyl-activating enzyme (AAE) consensus motif; other site
321314007165	putative AMP binding site [chemical binding]; other site
321314007166	putative active site [active]
321314007167	putative CoA binding site [chemical binding]; other site
321314007168	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
321314007169	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
321314007170	active site
321314007171	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
321314007172	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
321314007173	substrate binding site [chemical binding]; other site
321314007174	oxyanion hole (OAH) forming residues; other site
321314007175	trimer interface [polypeptide binding]; other site
321314007176	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
321314007177	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
321314007178	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
321314007179	dimer interface [polypeptide binding]; other site
321314007180	tetramer interface [polypeptide binding]; other site
321314007181	PYR/PP interface [polypeptide binding]; other site
321314007182	TPP binding site [chemical binding]; other site
321314007183	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
321314007184	TPP-binding site; other site
321314007185	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
321314007186	isochorismate synthases; Region: isochor_syn; TIGR00543
321314007187	hypothetical protein; Provisional; Region: PRK10404
321314007188	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314007189	Coenzyme A binding pocket [chemical binding]; other site
321314007190	ribonuclease BN; Region: true_RNase_BN; TIGR02649
321314007191	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
321314007192	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
321314007193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314007194	active site
321314007195	phosphorylation site [posttranslational modification]
321314007196	intermolecular recognition site; other site
321314007197	dimerization interface [polypeptide binding]; other site
321314007198	von Willebrand factor; Region: vWF_A; pfam12450
321314007199	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
321314007200	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
321314007201	metal ion-dependent adhesion site (MIDAS); other site
321314007202	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
321314007203	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
321314007204	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
321314007205	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
321314007206	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
321314007207	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
321314007208	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
321314007209	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
321314007210	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
321314007211	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
321314007212	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
321314007213	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
321314007214	4Fe-4S binding domain; Region: Fer4; pfam00037
321314007215	4Fe-4S binding domain; Region: Fer4; pfam00037
321314007216	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
321314007217	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
321314007218	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
321314007219	catalytic loop [active]
321314007220	iron binding site [ion binding]; other site
321314007221	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
321314007222	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
321314007223	[4Fe-4S] binding site [ion binding]; other site
321314007224	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
321314007225	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
321314007226	SLBB domain; Region: SLBB; pfam10531
321314007227	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
321314007228	NADH dehydrogenase subunit E; Validated; Region: PRK07539
321314007229	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
321314007230	putative dimer interface [polypeptide binding]; other site
321314007231	[2Fe-2S] cluster binding site [ion binding]; other site
321314007232	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
321314007233	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
321314007234	NADH dehydrogenase subunit D; Validated; Region: PRK06075
321314007235	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
321314007236	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
321314007237	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
321314007238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314007239	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
321314007240	putative dimerization interface [polypeptide binding]; other site
321314007241	aminotransferase AlaT; Validated; Region: PRK09265
321314007242	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314007243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314007244	homodimer interface [polypeptide binding]; other site
321314007245	catalytic residue [active]
321314007246	5'-nucleotidase; Provisional; Region: PRK03826
321314007247	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
321314007248	transmembrane helices; other site
321314007249	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
321314007250	TrkA-C domain; Region: TrkA_C; pfam02080
321314007251	TrkA-C domain; Region: TrkA_C; pfam02080
321314007252	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
321314007253	putative phosphatase; Provisional; Region: PRK11587
321314007254	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314007255	motif II; other site
321314007256	hypothetical protein; Validated; Region: PRK05445
321314007257	hypothetical protein; Provisional; Region: PRK01816
321314007258	propionate/acetate kinase; Provisional; Region: PRK12379
321314007259	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
321314007260	phosphate acetyltransferase; Reviewed; Region: PRK05632
321314007261	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
321314007262	DRTGG domain; Region: DRTGG; pfam07085
321314007263	phosphate acetyltransferase; Region: pta; TIGR00651
321314007264	hypothetical protein; Provisional; Region: PRK11588
321314007265	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
321314007266	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
321314007267	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
321314007268	PYR/PP interface [polypeptide binding]; other site
321314007269	dimer interface [polypeptide binding]; other site
321314007270	TPP binding site [chemical binding]; other site
321314007271	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
321314007272	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
321314007273	TPP-binding site [chemical binding]; other site
321314007274	dimer interface [polypeptide binding]; other site
321314007275	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
321314007276	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
321314007277	active site
321314007278	P-loop; other site
321314007279	phosphorylation site [posttranslational modification]
321314007280	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314007281	active site
321314007282	phosphorylation site [posttranslational modification]
321314007283	Transcriptional regulators [Transcription]; Region: PurR; COG1609
321314007284	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314007285	DNA binding site [nucleotide binding]
321314007286	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
321314007287	putative dimerization interface [polypeptide binding]; other site
321314007288	putative ligand binding site [chemical binding]; other site
321314007289	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
321314007290	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
321314007291	nudix motif; other site
321314007292	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
321314007293	active site
321314007294	metal binding site [ion binding]; metal-binding site
321314007295	homotetramer interface [polypeptide binding]; other site
321314007296	glutathione S-transferase; Provisional; Region: PRK15113
321314007297	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
321314007298	C-terminal domain interface [polypeptide binding]; other site
321314007299	GSH binding site (G-site) [chemical binding]; other site
321314007300	dimer interface [polypeptide binding]; other site
321314007301	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
321314007302	N-terminal domain interface [polypeptide binding]; other site
321314007303	putative dimer interface [polypeptide binding]; other site
321314007304	putative substrate binding pocket (H-site) [chemical binding]; other site
321314007305	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
321314007306	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
321314007307	C-terminal domain interface [polypeptide binding]; other site
321314007308	GSH binding site (G-site) [chemical binding]; other site
321314007309	dimer interface [polypeptide binding]; other site
321314007310	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
321314007311	N-terminal domain interface [polypeptide binding]; other site
321314007312	putative dimer interface [polypeptide binding]; other site
321314007313	active site
321314007314	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
321314007315	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
321314007316	putative NAD(P) binding site [chemical binding]; other site
321314007317	putative active site [active]
321314007318	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
321314007319	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
321314007320	Walker A/P-loop; other site
321314007321	ATP binding site [chemical binding]; other site
321314007322	Q-loop/lid; other site
321314007323	ABC transporter signature motif; other site
321314007324	Walker B; other site
321314007325	D-loop; other site
321314007326	H-loop/switch region; other site
321314007327	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314007328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314007329	dimer interface [polypeptide binding]; other site
321314007330	conserved gate region; other site
321314007331	putative PBP binding loops; other site
321314007332	ABC-ATPase subunit interface; other site
321314007333	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
321314007334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314007335	dimer interface [polypeptide binding]; other site
321314007336	conserved gate region; other site
321314007337	putative PBP binding loops; other site
321314007338	ABC-ATPase subunit interface; other site
321314007339	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
321314007340	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314007341	substrate binding pocket [chemical binding]; other site
321314007342	membrane-bound complex binding site; other site
321314007343	hinge residues; other site
321314007344	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
321314007345	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314007346	substrate binding pocket [chemical binding]; other site
321314007347	membrane-bound complex binding site; other site
321314007348	hinge residues; other site
321314007349	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
321314007350	Flavoprotein; Region: Flavoprotein; pfam02441
321314007351	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
321314007352	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
321314007353	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
321314007354	dimer interface [polypeptide binding]; other site
321314007355	active site
321314007356	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
321314007357	substrate binding site [chemical binding]; other site
321314007358	catalytic residue [active]
321314007359	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
321314007360	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
321314007361	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
321314007362	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
321314007363	catalytic residue [active]
321314007364	PAS fold; Region: PAS_4; pfam08448
321314007365	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
321314007366	putative active site [active]
321314007367	heme pocket [chemical binding]; other site
321314007368	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
321314007369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314007370	Walker A motif; other site
321314007371	ATP binding site [chemical binding]; other site
321314007372	Walker B motif; other site
321314007373	arginine finger; other site
321314007374	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
321314007375	amidophosphoribosyltransferase; Provisional; Region: PRK09246
321314007376	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
321314007377	active site
321314007378	tetramer interface [polypeptide binding]; other site
321314007379	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314007380	active site
321314007381	colicin V production protein; Provisional; Region: PRK10845
321314007382	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
321314007383	cell division protein DedD; Provisional; Region: PRK11633
321314007384	Sporulation related domain; Region: SPOR; pfam05036
321314007385	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
321314007386	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
321314007387	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
321314007388	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
321314007389	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
321314007390	hypothetical protein; Provisional; Region: PRK10847
321314007391	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
321314007392	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
321314007393	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
321314007394	dimerization interface 3.5A [polypeptide binding]; other site
321314007395	active site
321314007396	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
321314007397	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
321314007398	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
321314007399	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
321314007400	ligand binding site [chemical binding]; other site
321314007401	NAD binding site [chemical binding]; other site
321314007402	catalytic site [active]
321314007403	homodimer interface [polypeptide binding]; other site
321314007404	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
321314007405	putative transporter; Provisional; Region: PRK12382
321314007406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007407	putative substrate translocation pore; other site
321314007408	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314007409	non-specific DNA binding site [nucleotide binding]; other site
321314007410	salt bridge; other site
321314007411	sequence-specific DNA binding site [nucleotide binding]; other site
321314007412	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
321314007413	CAAX protease self-immunity; Region: Abi; pfam02517
321314007414	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
321314007415	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
321314007416	dimer interface [polypeptide binding]; other site
321314007417	active site
321314007418	Uncharacterized conserved protein [Function unknown]; Region: COG4121
321314007419	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
321314007420	YfcL protein; Region: YfcL; pfam08891
321314007421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
321314007422	hypothetical protein; Provisional; Region: PRK10621
321314007423	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
321314007424	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
321314007425	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
321314007426	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
321314007427	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
321314007428	Tetramer interface [polypeptide binding]; other site
321314007429	active site
321314007430	FMN-binding site [chemical binding]; other site
321314007431	HemK family putative methylases; Region: hemK_fam; TIGR00536
321314007432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314007433	S-adenosylmethionine binding site [chemical binding]; other site
321314007434	hypothetical protein; Provisional; Region: PRK04946
321314007435	Smr domain; Region: Smr; pfam01713
321314007436	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
321314007437	catalytic core [active]
321314007438	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
321314007439	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
321314007440	substrate binding site [chemical binding]; other site
321314007441	oxyanion hole (OAH) forming residues; other site
321314007442	trimer interface [polypeptide binding]; other site
321314007443	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
321314007444	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
321314007445	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
321314007446	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
321314007447	dimer interface [polypeptide binding]; other site
321314007448	active site
321314007449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
321314007450	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
321314007451	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
321314007452	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
321314007453	outer membrane protease; Reviewed; Region: PRK10993
321314007454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314007455	active site
321314007456	phosphorylation site [posttranslational modification]
321314007457	intermolecular recognition site; other site
321314007458	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
321314007459	dimerization interface [polypeptide binding]; other site
321314007460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
321314007461	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
321314007462	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
321314007463	HAMP domain; Region: HAMP; pfam00672
321314007464	dimerization interface [polypeptide binding]; other site
321314007465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314007466	dimer interface [polypeptide binding]; other site
321314007467	phosphorylation site [posttranslational modification]
321314007468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314007469	ATP binding site [chemical binding]; other site
321314007470	Mg2+ binding site [ion binding]; other site
321314007471	G-X-G motif; other site
321314007472	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
321314007473	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
321314007474	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
321314007475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007477	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
321314007478	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
321314007479	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
321314007480	putative acyl-acceptor binding pocket; other site
321314007481	Integrase core domain; Region: rve; pfam00665
321314007482	Integrase core domain; Region: rve_3; pfam13683
321314007483	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314007484	aminotransferase; Validated; Region: PRK08175
321314007485	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314007486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314007487	homodimer interface [polypeptide binding]; other site
321314007488	catalytic residue [active]
321314007489	similar to IS200
321314007490	similar to IS200
321314007491	glucokinase; Provisional; Region: glk; PRK00292
321314007492	glucokinase, proteobacterial type; Region: glk; TIGR00749
321314007493	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
321314007494	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
321314007495	Cl- selectivity filter; other site
321314007496	Cl- binding residues [ion binding]; other site
321314007497	pore gating glutamate residue; other site
321314007498	dimer interface [polypeptide binding]; other site
321314007499	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
321314007500	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
321314007501	dimer interface [polypeptide binding]; other site
321314007502	PYR/PP interface [polypeptide binding]; other site
321314007503	TPP binding site [chemical binding]; other site
321314007504	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
321314007505	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
321314007506	TPP-binding site [chemical binding]; other site
321314007507	dimer interface [polypeptide binding]; other site
321314007508	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314007509	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314007510	active site
321314007511	catalytic tetrad [active]
321314007512	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
321314007513	manganese transport protein MntH; Reviewed; Region: PRK00701
321314007514	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
321314007515	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
321314007516	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
321314007517	Nucleoside recognition; Region: Gate; pfam07670
321314007518	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
321314007519	MASE1; Region: MASE1; pfam05231
321314007520	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
321314007521	diguanylate cyclase; Region: GGDEF; smart00267
321314007522	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314007523	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
321314007524	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
321314007525	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
321314007526	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
321314007527	active site
321314007528	HIGH motif; other site
321314007529	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
321314007530	active site
321314007531	KMSKS motif; other site
321314007532	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
321314007533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314007534	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
321314007535	putative dimerization interface [polypeptide binding]; other site
321314007536	putative substrate binding pocket [chemical binding]; other site
321314007537	XapX domain; Region: XapX; TIGR03510
321314007538	nucleoside transporter; Region: 2A0110; TIGR00889
321314007539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007540	putative substrate translocation pore; other site
321314007541	purine nucleoside phosphorylase; Provisional; Region: PRK08202
321314007542	hypothetical protein; Provisional; Region: PRK11528
321314007543	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314007544	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314007545	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
321314007546	putative dimerization interface [polypeptide binding]; other site
321314007547	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
321314007548	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
321314007549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
321314007550	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
321314007551	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
321314007552	nucleotide binding pocket [chemical binding]; other site
321314007553	K-X-D-G motif; other site
321314007554	catalytic site [active]
321314007555	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
321314007556	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
321314007557	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
321314007558	Dimer interface [polypeptide binding]; other site
321314007559	BRCT sequence motif; other site
321314007560	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
321314007561	cell division protein ZipA; Provisional; Region: PRK03427
321314007562	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
321314007563	FtsZ protein binding site [polypeptide binding]; other site
321314007564	putative sulfate transport protein CysZ; Validated; Region: PRK04949
321314007565	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
321314007566	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
321314007567	dimer interface [polypeptide binding]; other site
321314007568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314007569	catalytic residue [active]
321314007570	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
321314007571	dimerization domain swap beta strand [polypeptide binding]; other site
321314007572	regulatory protein interface [polypeptide binding]; other site
321314007573	active site
321314007574	regulatory phosphorylation site [posttranslational modification]; other site
321314007575	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
321314007576	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
321314007577	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
321314007578	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
321314007579	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
321314007580	HPr interaction site; other site
321314007581	glycerol kinase (GK) interaction site [polypeptide binding]; other site
321314007582	active site
321314007583	phosphorylation site [posttranslational modification]
321314007584	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
321314007585	dimer interface [polypeptide binding]; other site
321314007586	pyridoxamine kinase; Validated; Region: PRK05756
321314007587	pyridoxal binding site [chemical binding]; other site
321314007588	ATP binding site [chemical binding]; other site
321314007589	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
321314007590	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314007591	DNA-binding site [nucleotide binding]; DNA binding site
321314007592	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314007593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314007594	homodimer interface [polypeptide binding]; other site
321314007595	catalytic residue [active]
321314007596	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
321314007597	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
321314007598	catalytic triad [active]
321314007599	hypothetical protein; Provisional; Region: PRK10318
321314007600	Transglycosylase; Region: Transgly; pfam00912
321314007601	cysteine synthase B; Region: cysM; TIGR01138
321314007602	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
321314007603	dimer interface [polypeptide binding]; other site
321314007604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314007605	catalytic residue [active]
321314007606	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
321314007607	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
321314007608	Walker A/P-loop; other site
321314007609	ATP binding site [chemical binding]; other site
321314007610	Q-loop/lid; other site
321314007611	ABC transporter signature motif; other site
321314007612	Walker B; other site
321314007613	D-loop; other site
321314007614	H-loop/switch region; other site
321314007615	TOBE-like domain; Region: TOBE_3; pfam12857
321314007616	sulfate transport protein; Provisional; Region: cysT; CHL00187
321314007617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314007618	dimer interface [polypeptide binding]; other site
321314007619	conserved gate region; other site
321314007620	putative PBP binding loops; other site
321314007621	ABC-ATPase subunit interface; other site
321314007622	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
321314007623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314007624	dimer interface [polypeptide binding]; other site
321314007625	conserved gate region; other site
321314007626	putative PBP binding loops; other site
321314007627	ABC-ATPase subunit interface; other site
321314007628	thiosulfate transporter subunit; Provisional; Region: PRK10852
321314007629	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
321314007630	short chain dehydrogenase; Provisional; Region: PRK08226
321314007631	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
321314007632	NAD binding site [chemical binding]; other site
321314007633	homotetramer interface [polypeptide binding]; other site
321314007634	homodimer interface [polypeptide binding]; other site
321314007635	active site
321314007636	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
321314007637	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
321314007638	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
321314007639	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
321314007640	putative acetyltransferase; Provisional; Region: PRK03624
321314007641	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314007642	Coenzyme A binding pocket [chemical binding]; other site
321314007643	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
321314007644	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
321314007645	active site
321314007646	metal binding site [ion binding]; metal-binding site
321314007647	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
321314007648	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
321314007649	transcriptional regulator EutR; Provisional; Region: PRK10130
321314007650	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314007651	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
321314007652	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
321314007653	putative hexamer interface [polypeptide binding]; other site
321314007654	putative hexagonal pore; other site
321314007655	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
321314007656	putative hexamer interface [polypeptide binding]; other site
321314007657	putative hexagonal pore; other site
321314007658	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
321314007659	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
321314007660	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
321314007661	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
321314007662	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
321314007663	active site
321314007664	metal binding site [ion binding]; metal-binding site
321314007665	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
321314007666	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314007667	nucleotide binding site [chemical binding]; other site
321314007668	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
321314007669	putative catalytic cysteine [active]
321314007670	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
321314007671	Hexamer/Pentamer interface [polypeptide binding]; other site
321314007672	central pore; other site
321314007673	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
321314007674	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
321314007675	Hexamer interface [polypeptide binding]; other site
321314007676	Putative hexagonal pore residue; other site
321314007677	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
321314007678	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
321314007679	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
321314007680	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
321314007681	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
321314007682	G1 box; other site
321314007683	GTP/Mg2+ binding site [chemical binding]; other site
321314007684	G2 box; other site
321314007685	Switch I region; other site
321314007686	G3 box; other site
321314007687	Switch II region; other site
321314007688	G4 box; other site
321314007689	G5 box; other site
321314007690	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
321314007691	putative hexamer interface [polypeptide binding]; other site
321314007692	putative hexagonal pore; other site
321314007693	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
321314007694	Malic enzyme, N-terminal domain; Region: malic; pfam00390
321314007695	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
321314007696	putative NAD(P) binding site [chemical binding]; other site
321314007697	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
321314007698	transaldolase-like protein; Provisional; Region: PTZ00411
321314007699	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
321314007700	active site
321314007701	dimer interface [polypeptide binding]; other site
321314007702	catalytic residue [active]
321314007703	transketolase; Reviewed; Region: PRK12753
321314007704	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
321314007705	TPP-binding site [chemical binding]; other site
321314007706	dimer interface [polypeptide binding]; other site
321314007707	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
321314007708	PYR/PP interface [polypeptide binding]; other site
321314007709	dimer interface [polypeptide binding]; other site
321314007710	TPP binding site [chemical binding]; other site
321314007711	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
321314007712	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
321314007713	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
321314007714	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
321314007715	dimer interface [polypeptide binding]; other site
321314007716	ADP-ribose binding site [chemical binding]; other site
321314007717	active site
321314007718	nudix motif; other site
321314007719	metal binding site [ion binding]; metal-binding site
321314007720	putative periplasmic esterase; Provisional; Region: PRK03642
321314007721	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
321314007722	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
321314007723	4Fe-4S binding domain; Region: Fer4; pfam00037
321314007724	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
321314007725	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314007726	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
321314007727	Protein export membrane protein; Region: SecD_SecF; cl14618
321314007728	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
321314007729	ArsC family; Region: ArsC; pfam03960
321314007730	putative catalytic residues [active]
321314007731	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
321314007732	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
321314007733	metal binding site [ion binding]; metal-binding site
321314007734	dimer interface [polypeptide binding]; other site
321314007735	hypothetical protein; Provisional; Region: PRK13664
321314007736	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
321314007737	Helicase; Region: Helicase_RecD; pfam05127
321314007738	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
321314007739	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
321314007740	Predicted metalloprotease [General function prediction only]; Region: COG2321
321314007741	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
321314007742	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
321314007743	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
321314007744	ATP binding site [chemical binding]; other site
321314007745	active site
321314007746	substrate binding site [chemical binding]; other site
321314007747	lipoprotein; Provisional; Region: PRK11679
321314007748	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
321314007749	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
321314007750	dihydrodipicolinate synthase; Region: dapA; TIGR00674
321314007751	dimer interface [polypeptide binding]; other site
321314007752	active site
321314007753	catalytic residue [active]
321314007754	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
321314007755	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
321314007756	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
321314007757	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
321314007758	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
321314007759	catalytic triad [active]
321314007760	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
321314007761	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
321314007762	fructuronate transporter; Provisional; Region: PRK10034; cl15264
321314007763	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
321314007764	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
321314007765	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
321314007766	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
321314007767	Domain of unknown function DUF20; Region: UPF0118; pfam01594
321314007768	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
321314007769	Peptidase family M48; Region: Peptidase_M48; cl12018
321314007770	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
321314007771	ArsC family; Region: ArsC; pfam03960
321314007772	catalytic residues [active]
321314007773	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
321314007774	DNA replication initiation factor; Provisional; Region: PRK08084
321314007775	uracil transporter; Provisional; Region: PRK10720
321314007776	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314007777	active site
321314007778	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
321314007779	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
321314007780	dimerization interface [polypeptide binding]; other site
321314007781	putative ATP binding site [chemical binding]; other site
321314007782	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
321314007783	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
321314007784	active site
321314007785	substrate binding site [chemical binding]; other site
321314007786	cosubstrate binding site; other site
321314007787	catalytic site [active]
321314007788	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
321314007789	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
321314007790	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
321314007791	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
321314007792	putative active site [active]
321314007793	catalytic site [active]
321314007794	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
321314007795	domain interface [polypeptide binding]; other site
321314007796	active site
321314007797	catalytic site [active]
321314007798	exopolyphosphatase; Provisional; Region: PRK10854
321314007799	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
321314007800	MASE1; Region: MASE1; pfam05231
321314007801	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
321314007802	diguanylate cyclase; Region: GGDEF; smart00267
321314007803	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314007804	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
321314007805	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
321314007806	Integrase core domain; Region: rve; pfam00665
321314007807	SEC-C motif; Region: SEC-C; pfam02810
321314007808	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
321314007809	GMP synthase; Reviewed; Region: guaA; PRK00074
321314007810	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
321314007811	AMP/PPi binding site [chemical binding]; other site
321314007812	candidate oxyanion hole; other site
321314007813	catalytic triad [active]
321314007814	potential glutamine specificity residues [chemical binding]; other site
321314007815	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
321314007816	ATP Binding subdomain [chemical binding]; other site
321314007817	Ligand Binding sites [chemical binding]; other site
321314007818	Dimerization subdomain; other site
321314007819	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
321314007820	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
321314007821	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
321314007822	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
321314007823	active site
321314007824	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
321314007825	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
321314007826	generic binding surface II; other site
321314007827	generic binding surface I; other site
321314007828	outer membrane protein RatB; Provisional; Region: PRK15314
321314007829	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007830	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007831	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007832	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007833	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007834	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007835	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007836	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007837	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007838	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007839	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007840	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007841	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007842	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007843	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007844	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007845	outer membrane protein RatA; Provisional; Region: PRK15315
321314007846	Oxygen tolerance; Region: BatD; pfam13584
321314007847	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007848	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007849	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007850	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007851	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007852	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007853	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007854	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007855	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
321314007856	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
321314007857	intimin-like protein SinH; Provisional; Region: PRK15318
321314007858	intimin-like protein SinH; Provisional; Region: PRK15318
321314007859	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
321314007860	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
321314007861	GTP-binding protein Der; Reviewed; Region: PRK00093
321314007862	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
321314007863	G1 box; other site
321314007864	GTP/Mg2+ binding site [chemical binding]; other site
321314007865	Switch I region; other site
321314007866	G2 box; other site
321314007867	Switch II region; other site
321314007868	G3 box; other site
321314007869	G4 box; other site
321314007870	G5 box; other site
321314007871	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
321314007872	G1 box; other site
321314007873	GTP/Mg2+ binding site [chemical binding]; other site
321314007874	Switch I region; other site
321314007875	G2 box; other site
321314007876	G3 box; other site
321314007877	Switch II region; other site
321314007878	G4 box; other site
321314007879	G5 box; other site
321314007880	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
321314007881	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
321314007882	Trp docking motif [polypeptide binding]; other site
321314007883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
321314007884	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
321314007885	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
321314007886	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
321314007887	dimer interface [polypeptide binding]; other site
321314007888	motif 1; other site
321314007889	active site
321314007890	motif 2; other site
321314007891	motif 3; other site
321314007892	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
321314007893	anticodon binding site; other site
321314007894	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
321314007895	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
321314007896	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
321314007897	cytoskeletal protein RodZ; Provisional; Region: PRK10856
321314007898	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314007899	non-specific DNA binding site [nucleotide binding]; other site
321314007900	salt bridge; other site
321314007901	sequence-specific DNA binding site [nucleotide binding]; other site
321314007902	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
321314007903	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
321314007904	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314007905	FeS/SAM binding site; other site
321314007906	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
321314007907	active site
321314007908	multimer interface [polypeptide binding]; other site
321314007909	4Fe-4S binding domain; Region: Fer4; pfam00037
321314007910	hydrogenase 4 subunit H; Validated; Region: PRK08222
321314007911	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
321314007912	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
321314007913	4Fe-4S binding domain; Region: Fer4; pfam00037
321314007914	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
321314007915	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
321314007916	putative [Fe4-S4] binding site [ion binding]; other site
321314007917	putative molybdopterin cofactor binding site [chemical binding]; other site
321314007918	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
321314007919	putative molybdopterin cofactor binding site; other site
321314007920	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
321314007921	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
321314007922	active site residue [active]
321314007923	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
321314007924	active site residue [active]
321314007925	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
321314007926	aminopeptidase B; Provisional; Region: PRK05015
321314007927	Peptidase; Region: DUF3663; pfam12404
321314007928	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
321314007929	interface (dimer of trimers) [polypeptide binding]; other site
321314007930	Substrate-binding/catalytic site; other site
321314007931	Zn-binding sites [ion binding]; other site
321314007932	hypothetical protein; Provisional; Region: PRK10721
321314007933	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
321314007934	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
321314007935	catalytic loop [active]
321314007936	iron binding site [ion binding]; other site
321314007937	co-chaperone HscB; Provisional; Region: hscB; PRK05014
321314007938	DnaJ domain; Region: DnaJ; pfam00226
321314007939	HSP70 interaction site [polypeptide binding]; other site
321314007940	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
321314007941	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
321314007942	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
321314007943	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
321314007944	trimerization site [polypeptide binding]; other site
321314007945	active site
321314007946	cysteine desulfurase; Provisional; Region: PRK14012
321314007947	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
321314007948	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314007949	catalytic residue [active]
321314007950	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
321314007951	Rrf2 family protein; Region: rrf2_super; TIGR00738
321314007952	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
321314007953	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
321314007954	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
321314007955	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
321314007956	active site
321314007957	dimerization interface [polypeptide binding]; other site
321314007958	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
321314007959	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
321314007960	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
321314007961	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
321314007962	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
321314007963	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
321314007964	FAD binding pocket [chemical binding]; other site
321314007965	FAD binding motif [chemical binding]; other site
321314007966	phosphate binding motif [ion binding]; other site
321314007967	beta-alpha-beta structure motif; other site
321314007968	NAD binding pocket [chemical binding]; other site
321314007969	Iron coordination center [ion binding]; other site
321314007970	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
321314007971	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
321314007972	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
321314007973	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
321314007974	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
321314007975	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
321314007976	PRD domain; Region: PRD; pfam00874
321314007977	PRD domain; Region: PRD; pfam00874
321314007978	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
321314007979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314007980	putative substrate translocation pore; other site
321314007981	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
321314007982	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
321314007983	dimer interface [polypeptide binding]; other site
321314007984	active site
321314007985	glycine-pyridoxal phosphate binding site [chemical binding]; other site
321314007986	folate binding site [chemical binding]; other site
321314007987	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
321314007988	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
321314007989	heme-binding site [chemical binding]; other site
321314007990	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
321314007991	FAD binding pocket [chemical binding]; other site
321314007992	FAD binding motif [chemical binding]; other site
321314007993	phosphate binding motif [ion binding]; other site
321314007994	beta-alpha-beta structure motif; other site
321314007995	NAD binding pocket [chemical binding]; other site
321314007996	Heme binding  pocket [chemical binding]; other site
321314007997	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
321314007998	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314007999	DNA binding site [nucleotide binding]
321314008000	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
321314008001	lysine decarboxylase CadA; Provisional; Region: PRK15400
321314008002	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
321314008003	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
321314008004	homodimer interface [polypeptide binding]; other site
321314008005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314008006	catalytic residue [active]
321314008007	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
321314008008	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
321314008009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008010	putative substrate translocation pore; other site
321314008011	POT family; Region: PTR2; pfam00854
321314008012	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
321314008013	Nitrogen regulatory protein P-II; Region: P-II; smart00938
321314008014	response regulator GlrR; Provisional; Region: PRK15115
321314008015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314008016	active site
321314008017	phosphorylation site [posttranslational modification]
321314008018	intermolecular recognition site; other site
321314008019	dimerization interface [polypeptide binding]; other site
321314008020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314008021	Walker A motif; other site
321314008022	ATP binding site [chemical binding]; other site
321314008023	Walker B motif; other site
321314008024	arginine finger; other site
321314008025	hypothetical protein; Provisional; Region: PRK10722
321314008026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
321314008027	HAMP domain; Region: HAMP; pfam00672
321314008028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314008029	dimer interface [polypeptide binding]; other site
321314008030	phosphorylation site [posttranslational modification]
321314008031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314008032	ATP binding site [chemical binding]; other site
321314008033	Mg2+ binding site [ion binding]; other site
321314008034	G-X-G motif; other site
321314008035	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
321314008036	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
321314008037	dimerization interface [polypeptide binding]; other site
321314008038	ATP binding site [chemical binding]; other site
321314008039	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
321314008040	dimerization interface [polypeptide binding]; other site
321314008041	ATP binding site [chemical binding]; other site
321314008042	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
321314008043	putative active site [active]
321314008044	catalytic triad [active]
321314008045	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
321314008046	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314008047	substrate binding pocket [chemical binding]; other site
321314008048	membrane-bound complex binding site; other site
321314008049	hinge residues; other site
321314008050	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314008051	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314008052	catalytic residue [active]
321314008053	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
321314008054	nucleoside/Zn binding site; other site
321314008055	dimer interface [polypeptide binding]; other site
321314008056	catalytic motif [active]
321314008057	hypothetical protein; Provisional; Region: PRK11590
321314008058	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
321314008059	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
321314008060	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
321314008061	active site turn [active]
321314008062	phosphorylation site [posttranslational modification]
321314008063	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
321314008064	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
321314008065	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
321314008066	putative active site [active]
321314008067	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
321314008068	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
321314008069	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
321314008070	putative active site [active]
321314008071	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
321314008072	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
321314008073	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
321314008074	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
321314008075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008076	putative substrate translocation pore; other site
321314008077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314008078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314008079	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
321314008080	dimerization interface [polypeptide binding]; other site
321314008081	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
321314008082	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
321314008083	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
321314008084	active site
321314008085	hydrophilic channel; other site
321314008086	dimerization interface [polypeptide binding]; other site
321314008087	catalytic residues [active]
321314008088	active site lid [active]
321314008089	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
321314008090	Recombination protein O N terminal; Region: RecO_N; pfam11967
321314008091	Recombination protein O C terminal; Region: RecO_C; pfam02565
321314008092	GTPase Era; Reviewed; Region: era; PRK00089
321314008093	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
321314008094	G1 box; other site
321314008095	GTP/Mg2+ binding site [chemical binding]; other site
321314008096	Switch I region; other site
321314008097	G2 box; other site
321314008098	Switch II region; other site
321314008099	G3 box; other site
321314008100	G4 box; other site
321314008101	G5 box; other site
321314008102	KH domain; Region: KH_2; pfam07650
321314008103	ribonuclease III; Reviewed; Region: rnc; PRK00102
321314008104	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
321314008105	dimerization interface [polypeptide binding]; other site
321314008106	active site
321314008107	metal binding site [ion binding]; metal-binding site
321314008108	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
321314008109	dsRNA binding site [nucleotide binding]; other site
321314008110	signal peptidase I; Provisional; Region: PRK10861
321314008111	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
321314008112	Catalytic site [active]
321314008113	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
321314008114	GTP-binding protein LepA; Provisional; Region: PRK05433
321314008115	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
321314008116	G1 box; other site
321314008117	putative GEF interaction site [polypeptide binding]; other site
321314008118	GTP/Mg2+ binding site [chemical binding]; other site
321314008119	Switch I region; other site
321314008120	G2 box; other site
321314008121	G3 box; other site
321314008122	Switch II region; other site
321314008123	G4 box; other site
321314008124	G5 box; other site
321314008125	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
321314008126	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
321314008127	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
321314008128	type III secretion protein GogB; Provisional; Region: PRK15386
321314008129	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
321314008130	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
321314008131	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
321314008132	Baseplate J-like protein; Region: Baseplate_J; cl01294
321314008133	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
321314008134	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
321314008135	BRO family, N-terminal domain; Region: Bro-N; smart01040
321314008136	BRO family, N-terminal domain; Region: Bro-N; smart01040
321314008137	Arc-like DNA binding domain; Region: Arc; pfam03869
321314008138	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
321314008139	virion protein; Provisional; Region: V; PHA02564
321314008140	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
321314008141	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
321314008142	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
321314008143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
321314008144	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
321314008145	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
321314008146	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
321314008147	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
321314008148	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
321314008149	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
321314008150	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
321314008151	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
321314008152	catalytic residues [active]
321314008153	phage holin, lambda family; Region: holin_lambda; TIGR01594
321314008154	PipA protein; Region: PipA; pfam07108
321314008155	Antitermination protein; Region: Antiterm; pfam03589
321314008156	Antitermination protein; Region: Antiterm; pfam03589
321314008157	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
321314008158	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
321314008159	DinI-like family; Region: DinI; pfam06183
321314008160	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
321314008161	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
321314008162	putative replication protein; Provisional; Region: PRK12377
321314008163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
321314008164	Walker A motif; other site
321314008165	ATP binding site [chemical binding]; other site
321314008166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
321314008167	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
321314008168	primosomal protein DnaI; Provisional; Region: PRK02854
321314008169	Bacteriophage CII protein; Region: Phage_CII; pfam05269
321314008170	transcriptional repressor DicA; Reviewed; Region: PRK09706
321314008171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314008172	non-specific DNA binding site [nucleotide binding]; other site
321314008173	salt bridge; other site
321314008174	sequence-specific DNA binding site [nucleotide binding]; other site
321314008175	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
321314008176	exonuclease VIII; Reviewed; Region: PRK09709
321314008177	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
321314008178	RecT family; Region: RecT; pfam03837
321314008179	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
321314008180	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
321314008181	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
321314008182	active site
321314008183	Int/Topo IB signature motif; other site
321314008184	SoxR reducing system protein RseC; Provisional; Region: PRK10862
321314008185	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
321314008186	anti-sigma E factor; Provisional; Region: rseB; PRK09455
321314008187	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
321314008188	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
321314008189	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
321314008190	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
321314008191	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
321314008192	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
321314008193	DNA binding residues [nucleotide binding]
321314008194	L-aspartate oxidase; Provisional; Region: PRK09077
321314008195	L-aspartate oxidase; Provisional; Region: PRK06175
321314008196	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
321314008197	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
321314008198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314008199	S-adenosylmethionine binding site [chemical binding]; other site
321314008200	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
321314008201	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
321314008202	ATP binding site [chemical binding]; other site
321314008203	Mg++ binding site [ion binding]; other site
321314008204	motif III; other site
321314008205	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314008206	nucleotide binding region [chemical binding]; other site
321314008207	ATP-binding site [chemical binding]; other site
321314008208	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314008209	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314008210	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
321314008211	dimerization interface [polypeptide binding]; other site
321314008212	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
321314008213	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
321314008214	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
321314008215	ligand binding site [chemical binding]; other site
321314008216	active site
321314008217	UGI interface [polypeptide binding]; other site
321314008218	catalytic site [active]
321314008219	putative methyltransferase; Provisional; Region: PRK10864
321314008220	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
321314008221	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
321314008222	thioredoxin 2; Provisional; Region: PRK10996
321314008223	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
321314008224	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
321314008225	catalytic residues [active]
321314008226	Uncharacterized conserved protein [Function unknown]; Region: COG3148
321314008227	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
321314008228	CoA binding domain; Region: CoA_binding_2; pfam13380
321314008229	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
321314008230	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
321314008231	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
321314008232	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314008233	Coenzyme A binding pocket [chemical binding]; other site
321314008234	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
321314008235	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
321314008236	domain interface [polypeptide binding]; other site
321314008237	putative active site [active]
321314008238	catalytic site [active]
321314008239	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
321314008240	domain interface [polypeptide binding]; other site
321314008241	putative active site [active]
321314008242	catalytic site [active]
321314008243	lipoprotein; Provisional; Region: PRK10759
321314008244	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
321314008245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008246	putative substrate translocation pore; other site
321314008247	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
321314008248	protein disaggregation chaperone; Provisional; Region: PRK10865
321314008249	Clp amino terminal domain; Region: Clp_N; pfam02861
321314008250	Clp amino terminal domain; Region: Clp_N; pfam02861
321314008251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314008252	Walker A motif; other site
321314008253	ATP binding site [chemical binding]; other site
321314008254	Walker B motif; other site
321314008255	arginine finger; other site
321314008256	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314008257	Walker A motif; other site
321314008258	ATP binding site [chemical binding]; other site
321314008259	Walker B motif; other site
321314008260	arginine finger; other site
321314008261	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
321314008262	hypothetical protein; Provisional; Region: PRK10723
321314008263	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
321314008264	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
321314008265	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314008266	RNA binding surface [nucleotide binding]; other site
321314008267	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
321314008268	active site
321314008269	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
321314008270	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
321314008271	30S subunit binding site; other site
321314008272	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
321314008273	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
321314008274	Prephenate dehydratase; Region: PDT; pfam00800
321314008275	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
321314008276	putative L-Phe binding site [chemical binding]; other site
321314008277	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
321314008278	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
321314008279	Chorismate mutase type II; Region: CM_2; cl00693
321314008280	prephenate dehydrogenase; Validated; Region: PRK08507
321314008281	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
321314008282	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
321314008283	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
321314008284	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
321314008285	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
321314008286	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
321314008287	RimM N-terminal domain; Region: RimM; pfam01782
321314008288	PRC-barrel domain; Region: PRC; pfam05239
321314008289	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
321314008290	signal recognition particle protein; Provisional; Region: PRK10867
321314008291	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
321314008292	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
321314008293	P loop; other site
321314008294	GTP binding site [chemical binding]; other site
321314008295	Signal peptide binding domain; Region: SRP_SPB; pfam02978
321314008296	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
321314008297	hypothetical protein; Provisional; Region: PRK11573
321314008298	Domain of unknown function DUF21; Region: DUF21; pfam01595
321314008299	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
321314008300	Transporter associated domain; Region: CorC_HlyC; smart01091
321314008301	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
321314008302	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
321314008303	dimer interface [polypeptide binding]; other site
321314008304	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
321314008305	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
321314008306	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
321314008307	recombination and repair protein; Provisional; Region: PRK10869
321314008308	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
321314008309	Walker A/P-loop; other site
321314008310	ATP binding site [chemical binding]; other site
321314008311	Q-loop/lid; other site
321314008312	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
321314008313	ABC transporter signature motif; other site
321314008314	Walker B; other site
321314008315	D-loop; other site
321314008316	H-loop/switch region; other site
321314008317	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
321314008318	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
321314008319	hypothetical protein; Validated; Region: PRK01777
321314008320	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
321314008321	putative coenzyme Q binding site [chemical binding]; other site
321314008322	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
321314008323	SmpB-tmRNA interface; other site
321314008324	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
321314008325	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
321314008326	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
321314008327	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314008328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314008329	Walker A/P-loop; other site
321314008330	ATP binding site [chemical binding]; other site
321314008331	Q-loop/lid; other site
321314008332	ABC transporter signature motif; other site
321314008333	Walker B; other site
321314008334	D-loop; other site
321314008335	H-loop/switch region; other site
321314008336	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
321314008337	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314008338	similar to IS911
321314008339	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
321314008340	Transposase; Region: HTH_Tnp_1; pfam01527
321314008341	putative transposase OrfB; Reviewed; Region: PHA02517
321314008342	HTH-like domain; Region: HTH_21; pfam13276
321314008343	Integrase core domain; Region: rve; pfam00665
321314008344	Integrase core domain; Region: rve_3; pfam13683
321314008345	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
321314008346	putative active site [active]
321314008347	putative NTP binding site [chemical binding]; other site
321314008348	putative nucleic acid binding site [nucleotide binding]; other site
321314008349	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
321314008350	Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614
321314008351	similar to Tn10
321314008352	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
321314008353	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
321314008354	catalytic residues [active]
321314008355	catalytic nucleophile [active]
321314008356	Presynaptic Site I dimer interface [polypeptide binding]; other site
321314008357	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
321314008358	Synaptic Flat tetramer interface [polypeptide binding]; other site
321314008359	Synaptic Site I dimer interface [polypeptide binding]; other site
321314008360	DNA binding site [nucleotide binding]
321314008361	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
321314008362	DNA-binding interface [nucleotide binding]; DNA binding site
321314008363	similar to IS200
321314008364	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
321314008365	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
321314008366	homodimer interface [polypeptide binding]; other site
321314008367	active site
321314008368	TDP-binding site; other site
321314008369	acceptor substrate-binding pocket; other site
321314008370	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314008371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314008372	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
321314008373	Walker A/P-loop; other site
321314008374	ATP binding site [chemical binding]; other site
321314008375	Q-loop/lid; other site
321314008376	ABC transporter signature motif; other site
321314008377	Walker B; other site
321314008378	D-loop; other site
321314008379	H-loop/switch region; other site
321314008380	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
321314008381	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
321314008382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314008383	Walker A/P-loop; other site
321314008384	ATP binding site [chemical binding]; other site
321314008385	Q-loop/lid; other site
321314008386	ABC transporter signature motif; other site
321314008387	Walker B; other site
321314008388	D-loop; other site
321314008389	H-loop/switch region; other site
321314008390	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
321314008391	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
321314008392	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
321314008393	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
321314008394	outer membrane receptor FepA; Provisional; Region: PRK13528
321314008395	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314008396	N-terminal plug; other site
321314008397	ligand-binding site [chemical binding]; other site
321314008398	secreted effector protein PipB2; Provisional; Region: PRK15196
321314008399	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314008400	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314008401	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314008402	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314008403	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
321314008404	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
321314008405	Mig-14; Region: Mig-14; pfam07395
321314008406	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
321314008407	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
321314008408	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
321314008409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
321314008410	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
321314008411	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314008412	dimer interface [polypeptide binding]; other site
321314008413	phosphorylation site [posttranslational modification]
321314008414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314008415	ATP binding site [chemical binding]; other site
321314008416	Mg2+ binding site [ion binding]; other site
321314008417	G-X-G motif; other site
321314008418	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
321314008419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314008420	active site
321314008421	phosphorylation site [posttranslational modification]
321314008422	intermolecular recognition site; other site
321314008423	dimerization interface [polypeptide binding]; other site
321314008424	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314008425	DNA binding site [nucleotide binding]
321314008426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
321314008427	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
321314008428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
321314008429	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
321314008430	substrate binding pocket [chemical binding]; other site
321314008431	active site
321314008432	iron coordination sites [ion binding]; other site
321314008433	Predicted dehydrogenase [General function prediction only]; Region: COG0579
321314008434	hydroxyglutarate oxidase; Provisional; Region: PRK11728
321314008435	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
321314008436	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
321314008437	tetramerization interface [polypeptide binding]; other site
321314008438	NAD(P) binding site [chemical binding]; other site
321314008439	catalytic residues [active]
321314008440	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
321314008441	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
321314008442	inhibitor-cofactor binding pocket; inhibition site
321314008443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314008444	catalytic residue [active]
321314008445	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
321314008446	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
321314008447	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314008448	DNA-binding site [nucleotide binding]; DNA binding site
321314008449	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
321314008450	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
321314008451	bacterial OsmY and nodulation domain; Region: BON; smart00749
321314008452	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314008453	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
321314008454	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314008455	dimerization interface [polypeptide binding]; other site
321314008456	putative DNA binding site [nucleotide binding]; other site
321314008457	putative Zn2+ binding site [ion binding]; other site
321314008458	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
321314008459	active site residue [active]
321314008460	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
321314008461	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
321314008462	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
321314008463	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
321314008464	hypothetical protein; Provisional; Region: PRK10556
321314008465	hypothetical protein; Provisional; Region: PRK10132
321314008466	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
321314008467	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314008468	DNA-binding site [nucleotide binding]; DNA binding site
321314008469	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314008470	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314008471	homodimer interface [polypeptide binding]; other site
321314008472	catalytic residue [active]
321314008473	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
321314008474	Uncharacterized conserved protein [Function unknown]; Region: COG2128
321314008475	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
321314008476	catalytic residues [active]
321314008477	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
321314008478	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
321314008479	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
321314008480	Class I ribonucleotide reductase; Region: RNR_I; cd01679
321314008481	active site
321314008482	dimer interface [polypeptide binding]; other site
321314008483	catalytic residues [active]
321314008484	effector binding site; other site
321314008485	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
321314008486	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
321314008487	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
321314008488	dimer interface [polypeptide binding]; other site
321314008489	putative radical transfer pathway; other site
321314008490	diiron center [ion binding]; other site
321314008491	tyrosyl radical; other site
321314008492	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
321314008493	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
321314008494	Walker A/P-loop; other site
321314008495	ATP binding site [chemical binding]; other site
321314008496	Q-loop/lid; other site
321314008497	ABC transporter signature motif; other site
321314008498	Walker B; other site
321314008499	D-loop; other site
321314008500	H-loop/switch region; other site
321314008501	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
321314008502	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
321314008503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314008504	dimer interface [polypeptide binding]; other site
321314008505	conserved gate region; other site
321314008506	putative PBP binding loops; other site
321314008507	ABC-ATPase subunit interface; other site
321314008508	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
321314008509	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
321314008510	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
321314008511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008512	transcriptional repressor MprA; Provisional; Region: PRK10870
321314008513	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
321314008514	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
321314008515	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314008516	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314008517	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
321314008518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008519	putative substrate translocation pore; other site
321314008520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008521	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
321314008522	S-ribosylhomocysteinase; Provisional; Region: PRK02260
321314008523	glutamate--cysteine ligase; Provisional; Region: PRK02107
321314008524	Predicted membrane protein [Function unknown]; Region: COG1238
321314008525	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
321314008526	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314008527	motif II; other site
321314008528	carbon storage regulator; Provisional; Region: PRK01712
321314008529	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
321314008530	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
321314008531	motif 1; other site
321314008532	active site
321314008533	motif 2; other site
321314008534	motif 3; other site
321314008535	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
321314008536	DHHA1 domain; Region: DHHA1; pfam02272
321314008537	recombination regulator RecX; Reviewed; Region: recX; PRK00117
321314008538	recombinase A; Provisional; Region: recA; PRK09354
321314008539	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
321314008540	hexamer interface [polypeptide binding]; other site
321314008541	Walker A motif; other site
321314008542	ATP binding site [chemical binding]; other site
321314008543	Walker B motif; other site
321314008544	hypothetical protein; Validated; Region: PRK03661
321314008545	Transglycosylase SLT domain; Region: SLT_2; pfam13406
321314008546	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314008547	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314008548	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
321314008549	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
321314008550	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
321314008551	Nucleoside recognition; Region: Gate; pfam07670
321314008552	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
321314008553	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
321314008554	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
321314008555	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
321314008556	putative NAD(P) binding site [chemical binding]; other site
321314008557	active site
321314008558	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
321314008559	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
321314008560	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
321314008561	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314008562	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
321314008563	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
321314008564	putative active site [active]
321314008565	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
321314008566	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
321314008567	GAF domain; Region: GAF; pfam01590
321314008568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314008569	Walker A motif; other site
321314008570	ATP binding site [chemical binding]; other site
321314008571	Walker B motif; other site
321314008572	arginine finger; other site
321314008573	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
321314008574	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
321314008575	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
321314008576	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
321314008577	iron binding site [ion binding]; other site
321314008578	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
321314008579	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314008580	Acylphosphatase; Region: Acylphosphatase; pfam00708
321314008581	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
321314008582	HypF finger; Region: zf-HYPF; pfam07503
321314008583	HypF finger; Region: zf-HYPF; pfam07503
321314008584	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
321314008585	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
321314008586	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
321314008587	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
321314008588	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
321314008589	nickel binding site [ion binding]; other site
321314008590	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
321314008591	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
321314008592	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
321314008593	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
321314008594	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
321314008595	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
321314008596	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
321314008597	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
321314008598	NADH dehydrogenase; Region: NADHdh; cl00469
321314008599	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
321314008600	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
321314008601	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
321314008602	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
321314008603	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
321314008604	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
321314008605	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
321314008606	hydrogenase assembly chaperone; Provisional; Region: PRK10409
321314008607	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
321314008608	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
321314008609	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
321314008610	dimerization interface [polypeptide binding]; other site
321314008611	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
321314008612	ATP binding site [chemical binding]; other site
321314008613	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
321314008614	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
321314008615	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
321314008616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314008617	Walker A motif; other site
321314008618	ATP binding site [chemical binding]; other site
321314008619	Walker B motif; other site
321314008620	arginine finger; other site
321314008621	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
321314008622	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
321314008623	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
321314008624	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
321314008625	metal binding site [ion binding]; metal-binding site
321314008626	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
321314008627	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
321314008628	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
321314008629	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314008630	ABC-ATPase subunit  interface; other site
321314008631	dimer interface [polypeptide binding]; other site
321314008632	putative PBP binding regions; other site
321314008633	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
321314008634	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
321314008635	ABC-ATPase subunit  interface; other site
321314008636	dimer interface [polypeptide binding]; other site
321314008637	putative PBP binding regions; other site
321314008638	transcriptional activator SprB; Provisional; Region: PRK15320
321314008639	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
321314008640	transcriptional regulator SirC; Provisional; Region: PRK15044
321314008641	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314008642	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
321314008643	invasion protein OrgB; Provisional; Region: PRK15322
321314008644	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
321314008645	invasion protein OrgA; Provisional; Region: PRK15323
321314008646	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
321314008647	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
321314008648	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
321314008649	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
321314008650	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
321314008651	transcriptional regulator HilD; Provisional; Region: PRK15185
321314008652	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314008653	invasion protein regulator; Provisional; Region: PRK12370
321314008654	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314008655	DNA binding site [nucleotide binding]
321314008656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
321314008657	binding surface
321314008658	TPR motif; other site
321314008659	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
321314008660	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314008661	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314008662	catalytic residue [active]
321314008663	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
321314008664	SicP binding; Region: SicP-binding; pfam09119
321314008665	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
321314008666	switch II binding region; other site
321314008667	Rac1 P-loop interaction site [polypeptide binding]; other site
321314008668	GTP binding residues [chemical binding]; other site
321314008669	switch I binding region; other site
321314008670	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
321314008671	active site
321314008672	chaperone protein SicP; Provisional; Region: PRK15329
321314008673	putative acyl carrier protein IacP; Validated; Region: PRK08172
321314008674	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
321314008675	cell invasion protein SipD; Provisional; Region: PRK15330
321314008676	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
321314008677	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
321314008678	chaperone protein SicA; Provisional; Region: PRK15331
321314008679	Tetratricopeptide repeat; Region: TPR_3; pfam07720
321314008680	Tetratricopeptide repeat; Region: TPR_3; pfam07720
321314008681	type III secretion system protein SpaS; Validated; Region: PRK08156
321314008682	type III secretion system protein SpaR; Provisional; Region: PRK15332
321314008683	type III secretion system protein SpaQ; Provisional; Region: PRK15333
321314008684	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
321314008685	type III secretion system protein SpaO; Validated; Region: PRK08158
321314008686	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
321314008687	antigen presentation protein SpaN; Provisional; Region: PRK15334
321314008688	Surface presentation of antigens protein; Region: SPAN; pfam02510
321314008689	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
321314008690	ATP synthase SpaL; Validated; Region: PRK08149
321314008691	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
321314008692	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
321314008693	Walker A motif; other site
321314008694	ATP binding site [chemical binding]; other site
321314008695	Walker B motif; other site
321314008696	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
321314008697	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
321314008698	type III secretion system protein InvA; Provisional; Region: PRK15337
321314008699	type III secretion system regulator InvE; Provisional; Region: PRK15338
321314008700	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
321314008701	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
321314008702	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
321314008703	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
321314008704	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
321314008705	transcriptional regulator InvF; Provisional; Region: PRK15340
321314008706	InvH outer membrane lipoprotein; Region: InvH; pfam04741
321314008707	similar to IS3
321314008708	similar to IS3
321314008709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
321314008710	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
321314008711	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
321314008712	active site
321314008713	metal binding site [ion binding]; metal-binding site
321314008714	similar to IS1414
321314008715	similar to IS1414
321314008716	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
321314008717	MutS domain I; Region: MutS_I; pfam01624
321314008718	MutS domain II; Region: MutS_II; pfam05188
321314008719	MutS domain III; Region: MutS_III; pfam05192
321314008720	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
321314008721	Walker A/P-loop; other site
321314008722	ATP binding site [chemical binding]; other site
321314008723	Q-loop/lid; other site
321314008724	ABC transporter signature motif; other site
321314008725	Walker B; other site
321314008726	D-loop; other site
321314008727	H-loop/switch region; other site
321314008728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
321314008729	GntP family permease; Region: GntP_permease; pfam02447
321314008730	fructuronate transporter; Provisional; Region: PRK10034; cl15264
321314008731	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
321314008732	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
321314008733	putative NAD(P) binding site [chemical binding]; other site
321314008734	active site
321314008735	putative substrate binding site [chemical binding]; other site
321314008736	hypothetical protein; Provisional; Region: PRK09989
321314008737	putative aldolase; Validated; Region: PRK08130
321314008738	intersubunit interface [polypeptide binding]; other site
321314008739	active site
321314008740	Zn2+ binding site [ion binding]; other site
321314008741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
321314008742	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
321314008743	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
321314008744	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314008745	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
321314008746	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314008747	MarR family; Region: MarR_2; cl17246
321314008748	Transcriptional regulators [Transcription]; Region: MarR; COG1846
321314008749	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
321314008750	Flavoprotein; Region: Flavoprotein; pfam02441
321314008751	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
321314008752	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
321314008753	Integrase core domain; Region: rve; pfam00665
321314008754	Integrase core domain; Region: rve_3; pfam13683
321314008755	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314008756	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
321314008757	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
321314008758	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
321314008759	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
321314008760	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
321314008761	DNA binding residues [nucleotide binding]
321314008762	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
321314008763	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314008764	Peptidase family M23; Region: Peptidase_M23; pfam01551
321314008765	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
321314008766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314008767	S-adenosylmethionine binding site [chemical binding]; other site
321314008768	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
321314008769	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
321314008770	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
321314008771	Permutation of conserved domain; other site
321314008772	active site
321314008773	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
321314008774	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
321314008775	homotrimer interaction site [polypeptide binding]; other site
321314008776	zinc binding site [ion binding]; other site
321314008777	CDP-binding sites; other site
321314008778	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
321314008779	substrate binding site; other site
321314008780	dimer interface; other site
321314008781	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
321314008782	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
321314008783	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
321314008784	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
321314008785	ligand-binding site [chemical binding]; other site
321314008786	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
321314008787	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
321314008788	CysD dimerization site [polypeptide binding]; other site
321314008789	G1 box; other site
321314008790	putative GEF interaction site [polypeptide binding]; other site
321314008791	GTP/Mg2+ binding site [chemical binding]; other site
321314008792	Switch I region; other site
321314008793	G2 box; other site
321314008794	G3 box; other site
321314008795	Switch II region; other site
321314008796	G4 box; other site
321314008797	G5 box; other site
321314008798	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
321314008799	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
321314008800	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
321314008801	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
321314008802	Active Sites [active]
321314008803	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
321314008804	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
321314008805	metal binding site [ion binding]; metal-binding site
321314008806	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
321314008807	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
321314008808	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
321314008809	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
321314008810	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
321314008811	CT1975-like protein; Region: Cas_CT1975; pfam09344
321314008812	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
321314008813	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
321314008814	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
321314008815	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
321314008816	Active Sites [active]
321314008817	sulfite reductase subunit beta; Provisional; Region: PRK13504
321314008818	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
321314008819	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
321314008820	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
321314008821	Flavodoxin; Region: Flavodoxin_1; pfam00258
321314008822	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
321314008823	FAD binding pocket [chemical binding]; other site
321314008824	FAD binding motif [chemical binding]; other site
321314008825	catalytic residues [active]
321314008826	NAD binding pocket [chemical binding]; other site
321314008827	phosphate binding motif [ion binding]; other site
321314008828	beta-alpha-beta structure motif; other site
321314008829	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
321314008830	active site
321314008831	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
321314008832	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314008833	Integrase core domain; Region: rve; pfam00665
321314008834	Integrase core domain; Region: rve_3; pfam13683
321314008835	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
321314008836	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
321314008837	enolase; Provisional; Region: eno; PRK00077
321314008838	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
321314008839	dimer interface [polypeptide binding]; other site
321314008840	metal binding site [ion binding]; metal-binding site
321314008841	substrate binding pocket [chemical binding]; other site
321314008842	CTP synthetase; Validated; Region: pyrG; PRK05380
321314008843	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
321314008844	Catalytic site [active]
321314008845	active site
321314008846	UTP binding site [chemical binding]; other site
321314008847	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
321314008848	active site
321314008849	putative oxyanion hole; other site
321314008850	catalytic triad [active]
321314008851	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
321314008852	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
321314008853	homodimer interface [polypeptide binding]; other site
321314008854	metal binding site [ion binding]; metal-binding site
321314008855	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
321314008856	homodimer interface [polypeptide binding]; other site
321314008857	active site
321314008858	putative chemical substrate binding site [chemical binding]; other site
321314008859	metal binding site [ion binding]; metal-binding site
321314008860	fimbrial protein SteA; Provisional; Region: PRK15261
321314008861	putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273
321314008862	PapC N-terminal domain; Region: PapC_N; pfam13954
321314008863	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314008864	PapC C-terminal domain; Region: PapC_C; pfam13953
321314008865	putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274
321314008866	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314008867	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314008868	putative fimbrial protein SteD; Provisional; Region: PRK15275
321314008869	putative fimbrial subunit SteE; Provisional; Region: PRK15276
321314008870	fimbrial protein SteF; Provisional; Region: PRK15260
321314008871	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
321314008872	HD domain; Region: HD_4; pfam13328
321314008873	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
321314008874	synthetase active site [active]
321314008875	NTP binding site [chemical binding]; other site
321314008876	metal binding site [ion binding]; metal-binding site
321314008877	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
321314008878	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
321314008879	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
321314008880	TRAM domain; Region: TRAM; pfam01938
321314008881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314008882	S-adenosylmethionine binding site [chemical binding]; other site
321314008883	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
321314008884	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
321314008885	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314008886	dimerization interface [polypeptide binding]; other site
321314008887	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314008888	dimer interface [polypeptide binding]; other site
321314008889	phosphorylation site [posttranslational modification]
321314008890	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314008891	ATP binding site [chemical binding]; other site
321314008892	Mg2+ binding site [ion binding]; other site
321314008893	G-X-G motif; other site
321314008894	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
321314008895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314008896	active site
321314008897	phosphorylation site [posttranslational modification]
321314008898	intermolecular recognition site; other site
321314008899	dimerization interface [polypeptide binding]; other site
321314008900	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
321314008901	putative binding surface; other site
321314008902	active site
321314008903	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
321314008904	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
321314008905	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
321314008906	active site
321314008907	tetramer interface [polypeptide binding]; other site
321314008908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008909	D-galactonate transporter; Region: 2A0114; TIGR00893
321314008910	putative substrate translocation pore; other site
321314008911	flavodoxin; Provisional; Region: PRK08105
321314008912	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
321314008913	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
321314008914	probable active site [active]
321314008915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
321314008916	SecY interacting protein Syd; Provisional; Region: PRK04968
321314008917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
321314008918	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
321314008919	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
321314008920	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
321314008921	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
321314008922	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
321314008923	serine transporter; Region: stp; TIGR00814
321314008924	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
321314008925	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
321314008926	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
321314008927	flap endonuclease-like protein; Provisional; Region: PRK09482
321314008928	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
321314008929	active site
321314008930	metal binding site 1 [ion binding]; metal-binding site
321314008931	putative 5' ssDNA interaction site; other site
321314008932	metal binding site 3; metal-binding site
321314008933	metal binding site 2 [ion binding]; metal-binding site
321314008934	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
321314008935	putative DNA binding site [nucleotide binding]; other site
321314008936	putative metal binding site [ion binding]; other site
321314008937	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
321314008938	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
321314008939	dimer interface [polypeptide binding]; other site
321314008940	active site
321314008941	metal binding site [ion binding]; metal-binding site
321314008942	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
321314008943	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
321314008944	intersubunit interface [polypeptide binding]; other site
321314008945	active site
321314008946	Zn2+ binding site [ion binding]; other site
321314008947	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
321314008948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314008949	putative substrate translocation pore; other site
321314008950	L-fucose isomerase; Provisional; Region: fucI; PRK10991
321314008951	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
321314008952	hexamer (dimer of trimers) interface [polypeptide binding]; other site
321314008953	trimer interface [polypeptide binding]; other site
321314008954	substrate binding site [chemical binding]; other site
321314008955	Mn binding site [ion binding]; other site
321314008956	L-fuculokinase; Provisional; Region: PRK10331
321314008957	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
321314008958	nucleotide binding site [chemical binding]; other site
321314008959	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
321314008960	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
321314008961	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
321314008962	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314008963	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
321314008964	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
321314008965	hypothetical protein; Provisional; Region: PRK10873
321314008966	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
321314008967	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314008968	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
321314008969	dimerization interface [polypeptide binding]; other site
321314008970	substrate binding pocket [chemical binding]; other site
321314008971	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
321314008972	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
321314008973	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
321314008974	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314008975	catalytic residue [active]
321314008976	CsdA-binding activator; Provisional; Region: PRK15019
321314008977	Predicted permeases [General function prediction only]; Region: RarD; COG2962
321314008978	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
321314008979	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
321314008980	putative ATP binding site [chemical binding]; other site
321314008981	putative substrate interface [chemical binding]; other site
321314008982	murein transglycosylase A; Provisional; Region: mltA; PRK11162
321314008983	murein hydrolase B; Provisional; Region: PRK10760; cl17906
321314008984	MltA specific insert domain; Region: MltA; pfam03562
321314008985	3D domain; Region: 3D; pfam06725
321314008986	AMIN domain; Region: AMIN; pfam11741
321314008987	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
321314008988	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
321314008989	active site
321314008990	metal binding site [ion binding]; metal-binding site
321314008991	N-acetylglutamate synthase; Validated; Region: PRK05279
321314008992	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
321314008993	putative feedback inhibition sensing region; other site
321314008994	putative nucleotide binding site [chemical binding]; other site
321314008995	putative substrate binding site [chemical binding]; other site
321314008996	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314008997	Coenzyme A binding pocket [chemical binding]; other site
321314008998	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
321314008999	AAA domain; Region: AAA_30; pfam13604
321314009000	Family description; Region: UvrD_C_2; pfam13538
321314009001	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
321314009002	protease3; Provisional; Region: PRK15101
321314009003	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
321314009004	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
321314009005	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
321314009006	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
321314009007	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
321314009008	hypothetical protein; Provisional; Region: PRK10332
321314009009	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
321314009010	hypothetical protein; Provisional; Region: PRK11521
321314009011	hypothetical protein; Provisional; Region: PRK10557
321314009012	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
321314009013	hypothetical protein; Provisional; Region: PRK10506
321314009014	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
321314009015	thymidylate synthase; Reviewed; Region: thyA; PRK01827
321314009016	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
321314009017	dimerization interface [polypeptide binding]; other site
321314009018	active site
321314009019	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
321314009020	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
321314009021	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
321314009022	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
321314009023	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
321314009024	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
321314009025	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
321314009026	putative active site [active]
321314009027	Ap4A binding site [chemical binding]; other site
321314009028	nudix motif; other site
321314009029	putative metal binding site [ion binding]; other site
321314009030	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
321314009031	putative DNA-binding cleft [nucleotide binding]; other site
321314009032	putative DNA clevage site; other site
321314009033	molecular lever; other site
321314009034	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
321314009035	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
321314009036	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314009037	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314009038	active site
321314009039	catalytic tetrad [active]
321314009040	lysophospholipid transporter LplT; Provisional; Region: PRK11195
321314009041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314009042	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
321314009043	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
321314009044	putative acyl-acceptor binding pocket; other site
321314009045	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
321314009046	acyl-activating enzyme (AAE) consensus motif; other site
321314009047	putative AMP binding site [chemical binding]; other site
321314009048	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
321314009049	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314009050	DNA binding site [nucleotide binding]
321314009051	domain linker motif; other site
321314009052	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
321314009053	dimerization interface (closed form) [polypeptide binding]; other site
321314009054	ligand binding site [chemical binding]; other site
321314009055	Transcriptional regulators [Transcription]; Region: PurR; COG1609
321314009056	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314009057	DNA binding site [nucleotide binding]
321314009058	domain linker motif; other site
321314009059	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
321314009060	dimerization interface (closed form) [polypeptide binding]; other site
321314009061	ligand binding site [chemical binding]; other site
321314009062	diaminopimelate decarboxylase; Provisional; Region: PRK11165
321314009063	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
321314009064	active site
321314009065	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
321314009066	substrate binding site [chemical binding]; other site
321314009067	catalytic residues [active]
321314009068	dimer interface [polypeptide binding]; other site
321314009069	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
321314009070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314009071	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314009072	dimerization interface [polypeptide binding]; other site
321314009073	putative racemase; Provisional; Region: PRK10200
321314009074	aspartate racemase; Region: asp_race; TIGR00035
321314009075	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
321314009076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314009077	putative substrate translocation pore; other site
321314009078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314009079	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
321314009080	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
321314009081	NADP binding site [chemical binding]; other site
321314009082	homodimer interface [polypeptide binding]; other site
321314009083	active site
321314009084	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
321314009085	putative acyltransferase; Provisional; Region: PRK05790
321314009086	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
321314009087	dimer interface [polypeptide binding]; other site
321314009088	active site
321314009089	LysR substrate binding domain; Region: LysR_substrate; pfam03466
321314009090	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314009091	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
321314009092	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
321314009093	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
321314009094	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
321314009095	putative metal binding site [ion binding]; other site
321314009096	putative homodimer interface [polypeptide binding]; other site
321314009097	putative homotetramer interface [polypeptide binding]; other site
321314009098	putative homodimer-homodimer interface [polypeptide binding]; other site
321314009099	putative allosteric switch controlling residues; other site
321314009100	transcriptional activator SprB; Provisional; Region: PRK15320
321314009101	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600
321314009102	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
321314009103	Fimbrial protein; Region: Fimbrial; cl01416
321314009104	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
321314009105	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314009106	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314009107	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
321314009108	PapC N-terminal domain; Region: PapC_N; pfam13954
321314009109	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314009110	PapC C-terminal domain; Region: PapC_C; pfam13953
321314009111	fimbrial protein StdA; Provisional; Region: PRK15210
321314009112	hypothetical protein; Provisional; Region: PRK10316
321314009113	YfdX protein; Region: YfdX; pfam10938
321314009114	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
321314009115	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
321314009116	oligomeric interface; other site
321314009117	putative active site [active]
321314009118	homodimer interface [polypeptide binding]; other site
321314009119	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
321314009120	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
321314009121	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
321314009122	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
321314009123	Peptidase family M23; Region: Peptidase_M23; pfam01551
321314009124	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
321314009125	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
321314009126	active site
321314009127	metal binding site [ion binding]; metal-binding site
321314009128	nudix motif; other site
321314009129	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
321314009130	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
321314009131	dimer interface [polypeptide binding]; other site
321314009132	putative anticodon binding site; other site
321314009133	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
321314009134	motif 1; other site
321314009135	active site
321314009136	motif 2; other site
321314009137	motif 3; other site
321314009138	This domain is found in peptide chain release factors; Region: PCRF; smart00937
321314009139	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
321314009140	RF-1 domain; Region: RF-1; pfam00472
321314009141	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
321314009142	DHH family; Region: DHH; pfam01368
321314009143	DHHA1 domain; Region: DHHA1; pfam02272
321314009144	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
321314009145	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
321314009146	dimerization domain [polypeptide binding]; other site
321314009147	dimer interface [polypeptide binding]; other site
321314009148	catalytic residues [active]
321314009149	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
321314009150	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
321314009151	active site
321314009152	Int/Topo IB signature motif; other site
321314009153	flavodoxin FldB; Provisional; Region: PRK12359
321314009154	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
321314009155	hypothetical protein; Provisional; Region: PRK10878
321314009156	putative global regulator; Reviewed; Region: PRK09559
321314009157	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
321314009158	hemolysin; Provisional; Region: PRK15087
321314009159	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
321314009160	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
321314009161	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
321314009162	beta-galactosidase; Region: BGL; TIGR03356
321314009163	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
321314009164	glycine dehydrogenase; Provisional; Region: PRK05367
321314009165	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
321314009166	tetramer interface [polypeptide binding]; other site
321314009167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314009168	catalytic residue [active]
321314009169	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
321314009170	tetramer interface [polypeptide binding]; other site
321314009171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314009172	catalytic residue [active]
321314009173	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
321314009174	lipoyl attachment site [posttranslational modification]; other site
321314009175	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
321314009176	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
321314009177	oxidoreductase; Provisional; Region: PRK08013
321314009178	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
321314009179	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
321314009180	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
321314009181	proline aminopeptidase P II; Provisional; Region: PRK10879
321314009182	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
321314009183	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
321314009184	active site
321314009185	hypothetical protein; Reviewed; Region: PRK01736
321314009186	Z-ring-associated protein; Provisional; Region: PRK10972
321314009187	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
321314009188	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
321314009189	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
321314009190	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
321314009191	ligand binding site [chemical binding]; other site
321314009192	NAD binding site [chemical binding]; other site
321314009193	tetramer interface [polypeptide binding]; other site
321314009194	catalytic site [active]
321314009195	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
321314009196	L-serine binding site [chemical binding]; other site
321314009197	ACT domain interface; other site
321314009198	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
321314009199	tetramer (dimer of dimers) interface [polypeptide binding]; other site
321314009200	active site
321314009201	dimer interface [polypeptide binding]; other site
321314009202	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
321314009203	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314009204	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
321314009205	putative dimerization interface [polypeptide binding]; other site
321314009206	Uncharacterized conserved protein [Function unknown]; Region: COG2968
321314009207	oxidative stress defense protein; Provisional; Region: PRK11087
321314009208	arginine exporter protein; Provisional; Region: PRK09304
321314009209	mechanosensitive channel MscS; Provisional; Region: PRK10334
321314009210	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314009211	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
321314009212	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
321314009213	active site
321314009214	intersubunit interface [polypeptide binding]; other site
321314009215	zinc binding site [ion binding]; other site
321314009216	Na+ binding site [ion binding]; other site
321314009217	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
321314009218	Phosphoglycerate kinase; Region: PGK; pfam00162
321314009219	substrate binding site [chemical binding]; other site
321314009220	hinge regions; other site
321314009221	ADP binding site [chemical binding]; other site
321314009222	catalytic site [active]
321314009223	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
321314009224	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
321314009225	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
321314009226	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
321314009227	trimer interface [polypeptide binding]; other site
321314009228	putative Zn binding site [ion binding]; other site
321314009229	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
321314009230	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
321314009231	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
321314009232	Walker A/P-loop; other site
321314009233	ATP binding site [chemical binding]; other site
321314009234	Q-loop/lid; other site
321314009235	ABC transporter signature motif; other site
321314009236	Walker B; other site
321314009237	D-loop; other site
321314009238	H-loop/switch region; other site
321314009239	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
321314009240	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
321314009241	Walker A/P-loop; other site
321314009242	ATP binding site [chemical binding]; other site
321314009243	Q-loop/lid; other site
321314009244	ABC transporter signature motif; other site
321314009245	Walker B; other site
321314009246	D-loop; other site
321314009247	H-loop/switch region; other site
321314009248	transketolase; Reviewed; Region: PRK12753
321314009249	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
321314009250	TPP-binding site [chemical binding]; other site
321314009251	dimer interface [polypeptide binding]; other site
321314009252	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
321314009253	PYR/PP interface [polypeptide binding]; other site
321314009254	dimer interface [polypeptide binding]; other site
321314009255	TPP binding site [chemical binding]; other site
321314009256	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
321314009257	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
321314009258	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
321314009259	agmatinase; Region: agmatinase; TIGR01230
321314009260	oligomer interface [polypeptide binding]; other site
321314009261	putative active site [active]
321314009262	Mn binding site [ion binding]; other site
321314009263	similar to Tn10
321314009264	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
321314009265	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
321314009266	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
321314009267	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
321314009268	putative NAD(P) binding site [chemical binding]; other site
321314009269	catalytic Zn binding site [ion binding]; other site
321314009270	structural Zn binding site [ion binding]; other site
321314009271	Transcriptional regulators [Transcription]; Region: FadR; COG2186
321314009272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314009273	DNA-binding site [nucleotide binding]; DNA binding site
321314009274	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
321314009275	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
321314009276	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
321314009277	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
321314009278	dimer interface [polypeptide binding]; other site
321314009279	active site
321314009280	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
321314009281	catalytic residues [active]
321314009282	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
321314009283	Virulence promoting factor; Region: YqgB; pfam11036
321314009284	Protein of unknown function (DUF2684); Region: DUF2684; pfam10885
321314009285	S-adenosylmethionine synthetase; Validated; Region: PRK05250
321314009286	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
321314009287	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
321314009288	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
321314009289	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
321314009290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314009291	putative substrate translocation pore; other site
321314009292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314009293	hypothetical protein; Provisional; Region: PRK04860
321314009294	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
321314009295	DNA-specific endonuclease I; Provisional; Region: PRK15137
321314009296	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
321314009297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
321314009298	RNA methyltransferase, RsmE family; Region: TIGR00046
321314009299	glutathione synthetase; Provisional; Region: PRK05246
321314009300	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
321314009301	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
321314009302	hypothetical protein; Validated; Region: PRK00228
321314009303	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
321314009304	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
321314009305	Transcriptional regulator [Transcription]; Region: IclR; COG1414
321314009306	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
321314009307	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
321314009308	Walker A motif; other site
321314009309	ATP binding site [chemical binding]; other site
321314009310	Walker B motif; other site
321314009311	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
321314009312	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
321314009313	catalytic residue [active]
321314009314	YGGT family; Region: YGGT; pfam02325
321314009315	YGGT family; Region: YGGT; pfam02325
321314009316	hypothetical protein; Validated; Region: PRK05090
321314009317	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
321314009318	active site
321314009319	dimerization interface [polypeptide binding]; other site
321314009320	HemN family oxidoreductase; Provisional; Region: PRK05660
321314009321	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314009322	FeS/SAM binding site; other site
321314009323	HemN C-terminal domain; Region: HemN_C; pfam06969
321314009324	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
321314009325	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
321314009326	homodimer interface [polypeptide binding]; other site
321314009327	active site
321314009328	hypothetical protein; Provisional; Region: PRK10626
321314009329	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
321314009330	hypothetical protein; Provisional; Region: PRK11702
321314009331	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
321314009332	adenine DNA glycosylase; Provisional; Region: PRK10880
321314009333	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
321314009334	minor groove reading motif; other site
321314009335	helix-hairpin-helix signature motif; other site
321314009336	substrate binding pocket [chemical binding]; other site
321314009337	active site
321314009338	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
321314009339	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
321314009340	DNA binding and oxoG recognition site [nucleotide binding]
321314009341	oxidative damage protection protein; Provisional; Region: PRK05408
321314009342	murein transglycosylase C; Provisional; Region: mltC; PRK11671
321314009343	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
321314009344	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314009345	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314009346	catalytic residue [active]
321314009347	nucleoside transporter; Region: 2A0110; TIGR00889
321314009348	ornithine decarboxylase; Provisional; Region: PRK13578
321314009349	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
321314009350	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
321314009351	homodimer interface [polypeptide binding]; other site
321314009352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314009353	catalytic residue [active]
321314009354	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
321314009355	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
321314009356	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
321314009357	dimer interface [polypeptide binding]; other site
321314009358	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
321314009359	metal binding site [ion binding]; metal-binding site
321314009360	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
321314009361	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
321314009362	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
321314009363	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
321314009364	putative active site [active]
321314009365	putative catalytic site [active]
321314009366	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
321314009367	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
321314009368	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314009369	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
321314009370	putative dimerization interface [polypeptide binding]; other site
321314009371	putative substrate binding pocket [chemical binding]; other site
321314009372	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
321314009373	Sulfatase; Region: Sulfatase; pfam00884
321314009374	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
321314009375	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314009376	FeS/SAM binding site; other site
321314009377	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
321314009378	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
321314009379	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314009380	DNA binding residues [nucleotide binding]
321314009381	dimerization interface [polypeptide binding]; other site
321314009382	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
321314009383	Amino acid permease; Region: AA_permease_2; pfam13520
321314009384	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
321314009385	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
321314009386	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
321314009387	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
321314009388	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
321314009389	NAD(P) binding site [chemical binding]; other site
321314009390	catalytic residues [active]
321314009391	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
321314009392	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
321314009393	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
321314009394	active site
321314009395	catalytic site [active]
321314009396	Zn binding site [ion binding]; other site
321314009397	tetramer interface [polypeptide binding]; other site
321314009398	Predicted amidohydrolase [General function prediction only]; Region: COG0388
321314009399	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
321314009400	putative active site [active]
321314009401	catalytic triad [active]
321314009402	putative dimer interface [polypeptide binding]; other site
321314009403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314009404	D-galactonate transporter; Region: 2A0114; TIGR00893
321314009405	putative substrate translocation pore; other site
321314009406	mannonate dehydratase; Provisional; Region: PRK03906
321314009407	mannonate dehydratase; Region: uxuA; TIGR00695
321314009408	D-mannonate oxidoreductase; Provisional; Region: PRK15037
321314009409	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
321314009410	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
321314009411	Glucuronate isomerase; Region: UxaC; pfam02614
321314009412	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
321314009413	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314009414	dimer interface [polypeptide binding]; other site
321314009415	putative CheW interface [polypeptide binding]; other site
321314009416	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
321314009417	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
321314009418	CHAP domain; Region: CHAP; pfam05257
321314009419	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
321314009420	putative S-transferase; Provisional; Region: PRK11752
321314009421	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
321314009422	C-terminal domain interface [polypeptide binding]; other site
321314009423	GSH binding site (G-site) [chemical binding]; other site
321314009424	dimer interface [polypeptide binding]; other site
321314009425	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
321314009426	dimer interface [polypeptide binding]; other site
321314009427	N-terminal domain interface [polypeptide binding]; other site
321314009428	active site
321314009429	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
321314009430	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
321314009431	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
321314009432	putative ligand binding residues [chemical binding]; other site
321314009433	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
321314009434	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
321314009435	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
321314009436	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
321314009437	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
321314009438	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
321314009439	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
321314009440	putative substrate-binding site; other site
321314009441	nickel binding site [ion binding]; other site
321314009442	hydrogenase 2 large subunit; Provisional; Region: PRK10467
321314009443	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
321314009444	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
321314009445	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
321314009446	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
321314009447	4Fe-4S binding domain; Region: Fer4_6; pfam12837
321314009448	hydrogenase 2 small subunit; Provisional; Region: PRK10468
321314009449	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
321314009450	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
321314009451	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
321314009452	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
321314009453	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314009454	dimerization interface [polypeptide binding]; other site
321314009455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314009456	dimer interface [polypeptide binding]; other site
321314009457	putative CheW interface [polypeptide binding]; other site
321314009458	hypothetical protein; Provisional; Region: PRK05208
321314009459	oxidoreductase; Provisional; Region: PRK07985
321314009460	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
321314009461	NAD binding site [chemical binding]; other site
321314009462	metal binding site [ion binding]; metal-binding site
321314009463	active site
321314009464	biopolymer transport protein ExbD; Provisional; Region: PRK11267
321314009465	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
321314009466	biopolymer transport protein ExbB; Provisional; Region: PRK10414
321314009467	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314009468	Integrase core domain; Region: rve; pfam00665
321314009469	Integrase core domain; Region: rve_3; pfam13683
321314009470	cystathionine beta-lyase; Provisional; Region: PRK08114
321314009471	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
321314009472	homodimer interface [polypeptide binding]; other site
321314009473	substrate-cofactor binding pocket; other site
321314009474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314009475	catalytic residue [active]
321314009476	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
321314009477	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
321314009478	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
321314009479	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
321314009480	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314009481	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314009482	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
321314009483	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
321314009484	dimer interface [polypeptide binding]; other site
321314009485	active site
321314009486	metal binding site [ion binding]; metal-binding site
321314009487	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
321314009488	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
321314009489	active site
321314009490	catalytic tetrad [active]
321314009491	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
321314009492	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
321314009493	transmembrane helices; other site
321314009494	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
321314009495	nucleotide binding site/active site [active]
321314009496	catalytic residue [active]
321314009497	hypothetical protein; Provisional; Region: PRK01254
321314009498	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
321314009499	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
321314009500	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
321314009501	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
321314009502	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
321314009503	DctM-like transporters; Region: DctM; pfam06808
321314009504	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
321314009505	FtsI repressor; Provisional; Region: PRK10883
321314009506	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
321314009507	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
321314009508	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
321314009509	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
321314009510	putative acyl-acceptor binding pocket; other site
321314009511	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
321314009512	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
321314009513	CAP-like domain; other site
321314009514	active site
321314009515	primary dimer interface [polypeptide binding]; other site
321314009516	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
321314009517	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314009518	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314009519	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
321314009520	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
321314009521	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
321314009522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314009523	active site
321314009524	phosphorylation site [posttranslational modification]
321314009525	intermolecular recognition site; other site
321314009526	dimerization interface [polypeptide binding]; other site
321314009527	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314009528	DNA binding site [nucleotide binding]
321314009529	sensor protein QseC; Provisional; Region: PRK10337
321314009530	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
321314009531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314009532	dimer interface [polypeptide binding]; other site
321314009533	phosphorylation site [posttranslational modification]
321314009534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314009535	ATP binding site [chemical binding]; other site
321314009536	Mg2+ binding site [ion binding]; other site
321314009537	G-X-G motif; other site
321314009538	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
321314009539	Uncharacterized conserved protein [Function unknown]; Region: COG1359
321314009540	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
321314009541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314009542	ATP binding site [chemical binding]; other site
321314009543	Mg2+ binding site [ion binding]; other site
321314009544	G-X-G motif; other site
321314009545	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
321314009546	anchoring element; other site
321314009547	dimer interface [polypeptide binding]; other site
321314009548	ATP binding site [chemical binding]; other site
321314009549	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
321314009550	active site
321314009551	metal binding site [ion binding]; metal-binding site
321314009552	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
321314009553	esterase YqiA; Provisional; Region: PRK11071
321314009554	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
321314009555	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
321314009556	active site
321314009557	metal binding site [ion binding]; metal-binding site
321314009558	hexamer interface [polypeptide binding]; other site
321314009559	putative dehydrogenase; Provisional; Region: PRK11039
321314009560	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
321314009561	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
321314009562	dimer interface [polypeptide binding]; other site
321314009563	ADP-ribose binding site [chemical binding]; other site
321314009564	active site
321314009565	nudix motif; other site
321314009566	metal binding site [ion binding]; metal-binding site
321314009567	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
321314009568	hypothetical protein; Provisional; Region: PRK11653
321314009569	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
321314009570	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
321314009571	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
321314009572	putative active site [active]
321314009573	metal binding site [ion binding]; metal-binding site
321314009574	zinc transporter ZupT; Provisional; Region: PRK04201
321314009575	ZIP Zinc transporter; Region: Zip; pfam02535
321314009576	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
321314009577	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
321314009578	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
321314009579	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
321314009580	catalytic residues [active]
321314009581	hinge region; other site
321314009582	alpha helical domain; other site
321314009583	putative disulfide oxidoreductase; Provisional; Region: PRK04307
321314009584	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314009585	Integrase core domain; Region: rve; pfam00665
321314009586	Integrase core domain; Region: rve_3; pfam13683
321314009587	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
321314009588	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
321314009589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
321314009590	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
321314009591	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
321314009592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
321314009593	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
321314009594	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
321314009595	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
321314009596	putative ribose interaction site [chemical binding]; other site
321314009597	putative ADP binding site [chemical binding]; other site
321314009598	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
321314009599	active site
321314009600	nucleotide binding site [chemical binding]; other site
321314009601	HIGH motif; other site
321314009602	KMSKS motif; other site
321314009603	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
321314009604	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
321314009605	metal binding triad; other site
321314009606	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
321314009607	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
321314009608	metal binding triad; other site
321314009609	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
321314009610	Uncharacterized conserved protein [Function unknown]; Region: COG3025
321314009611	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
321314009612	putative active site [active]
321314009613	putative metal binding residues [ion binding]; other site
321314009614	signature motif; other site
321314009615	putative triphosphate binding site [ion binding]; other site
321314009616	CHAD domain; Region: CHAD; pfam05235
321314009617	SH3 domain-containing protein; Provisional; Region: PRK10884
321314009618	Bacterial SH3 domain homologues; Region: SH3b; smart00287
321314009619	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
321314009620	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
321314009621	active site
321314009622	NTP binding site [chemical binding]; other site
321314009623	metal binding triad [ion binding]; metal-binding site
321314009624	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
321314009625	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
321314009626	Zn2+ binding site [ion binding]; other site
321314009627	Mg2+ binding site [ion binding]; other site
321314009628	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
321314009629	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
321314009630	homooctamer interface [polypeptide binding]; other site
321314009631	active site
321314009632	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
321314009633	UGMP family protein; Validated; Region: PRK09604
321314009634	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
321314009635	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
321314009636	DNA primase; Validated; Region: dnaG; PRK05667
321314009637	CHC2 zinc finger; Region: zf-CHC2; pfam01807
321314009638	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
321314009639	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
321314009640	active site
321314009641	metal binding site [ion binding]; metal-binding site
321314009642	interdomain interaction site; other site
321314009643	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
321314009644	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
321314009645	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
321314009646	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
321314009647	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
321314009648	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
321314009649	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
321314009650	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
321314009651	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
321314009652	DNA binding residues [nucleotide binding]
321314009653	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
321314009654	active site
321314009655	SUMO-1 interface [polypeptide binding]; other site
321314009656	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
321314009657	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
321314009658	FAD binding pocket [chemical binding]; other site
321314009659	FAD binding motif [chemical binding]; other site
321314009660	phosphate binding motif [ion binding]; other site
321314009661	NAD binding pocket [chemical binding]; other site
321314009662	Predicted transcriptional regulators [Transcription]; Region: COG1695
321314009663	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
321314009664	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
321314009665	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314009666	dimerization interface [polypeptide binding]; other site
321314009667	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
321314009668	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314009669	dimer interface [polypeptide binding]; other site
321314009670	putative CheW interface [polypeptide binding]; other site
321314009671	PAS fold; Region: PAS_3; pfam08447
321314009672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314009673	putative active site [active]
321314009674	heme pocket [chemical binding]; other site
321314009675	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
321314009676	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314009677	dimer interface [polypeptide binding]; other site
321314009678	putative CheW interface [polypeptide binding]; other site
321314009679	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
321314009680	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
321314009681	inhibitor-cofactor binding pocket; inhibition site
321314009682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314009683	catalytic residue [active]
321314009684	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
321314009685	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
321314009686	active site
321314009687	FMN binding site [chemical binding]; other site
321314009688	2,4-decadienoyl-CoA binding site; other site
321314009689	catalytic residue [active]
321314009690	4Fe-4S cluster binding site [ion binding]; other site
321314009691	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
321314009692	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314009693	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
321314009694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314009695	S-adenosylmethionine binding site [chemical binding]; other site
321314009696	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
321314009697	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
321314009698	putative active site [active]
321314009699	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
321314009700	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
321314009701	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
321314009702	serine/threonine transporter SstT; Provisional; Region: PRK13628
321314009703	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
321314009704	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
321314009705	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
321314009706	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
321314009707	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
321314009708	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
321314009709	Predicted membrane protein [Function unknown]; Region: COG5393
321314009710	YqjK-like protein; Region: YqjK; pfam13997
321314009711	Predicted membrane protein [Function unknown]; Region: COG2259
321314009712	Predicted membrane protein [Function unknown]; Region: COG3152
321314009713	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314009714	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
321314009715	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314009716	dimerization interface [polypeptide binding]; other site
321314009717	Pirin-related protein [General function prediction only]; Region: COG1741
321314009718	Pirin; Region: Pirin; pfam02678
321314009719	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
321314009720	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
321314009721	serine transporter; Region: stp; TIGR00814
321314009722	L-serine dehydratase TdcG; Provisional; Region: PRK15040
321314009723	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
321314009724	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
321314009725	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
321314009726	Pyruvate formate lyase 1; Region: PFL1; cd01678
321314009727	coenzyme A binding site [chemical binding]; other site
321314009728	active site
321314009729	catalytic residues [active]
321314009730	glycine loop; other site
321314009731	propionate/acetate kinase; Provisional; Region: PRK12379
321314009732	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
321314009733	threonine/serine transporter TdcC; Provisional; Region: PRK13629
321314009734	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
321314009735	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
321314009736	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
321314009737	tetramer interface [polypeptide binding]; other site
321314009738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314009739	catalytic residue [active]
321314009740	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
321314009741	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314009742	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
321314009743	putative substrate binding pocket [chemical binding]; other site
321314009744	putative dimerization interface [polypeptide binding]; other site
321314009745	glycerate kinase I; Provisional; Region: PRK10342
321314009746	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
321314009747	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
321314009748	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
321314009749	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
321314009750	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
321314009751	intersubunit interface [polypeptide binding]; other site
321314009752	active site
321314009753	zinc binding site [ion binding]; other site
321314009754	Na+ binding site [ion binding]; other site
321314009755	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
321314009756	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314009757	active site
321314009758	phosphorylation site [posttranslational modification]
321314009759	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
321314009760	active site
321314009761	P-loop; other site
321314009762	phosphorylation site [posttranslational modification]
321314009763	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
321314009764	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
321314009765	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
321314009766	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
321314009767	putative NAD(P) binding site [chemical binding]; other site
321314009768	catalytic Zn binding site [ion binding]; other site
321314009769	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314009770	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
321314009771	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314009772	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
321314009773	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
321314009774	putative SAM binding site [chemical binding]; other site
321314009775	putative homodimer interface [polypeptide binding]; other site
321314009776	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
321314009777	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
321314009778	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
321314009779	putative ligand binding site [chemical binding]; other site
321314009780	TIGR00252 family protein; Region: TIGR00252
321314009781	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
321314009782	dimer interface [polypeptide binding]; other site
321314009783	active site
321314009784	outer membrane lipoprotein; Provisional; Region: PRK11023
321314009785	BON domain; Region: BON; pfam04972
321314009786	BON domain; Region: BON; pfam04972
321314009787	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
321314009788	NADH(P)-binding; Region: NAD_binding_10; pfam13460
321314009789	NAD binding site [chemical binding]; other site
321314009790	active site
321314009791	intracellular protease, PfpI family; Region: PfpI; TIGR01382
321314009792	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
321314009793	proposed catalytic triad [active]
321314009794	conserved cys residue [active]
321314009795	hypothetical protein; Provisional; Region: PRK03467
321314009796	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
321314009797	GIY-YIG motif/motif A; other site
321314009798	putative active site [active]
321314009799	putative metal binding site [ion binding]; other site
321314009800	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
321314009801	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314009802	Coenzyme A binding pocket [chemical binding]; other site
321314009803	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
321314009804	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
321314009805	Peptidase family U32; Region: Peptidase_U32; pfam01136
321314009806	putative protease; Provisional; Region: PRK15447
321314009807	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
321314009808	hypothetical protein; Provisional; Region: PRK10508
321314009809	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
321314009810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
321314009811	tryptophan permease; Provisional; Region: PRK10483
321314009812	aromatic amino acid transport protein; Region: araaP; TIGR00837
321314009813	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
321314009814	DEAD-like helicases superfamily; Region: DEXDc; smart00487
321314009815	ATP binding site [chemical binding]; other site
321314009816	Mg++ binding site [ion binding]; other site
321314009817	motif III; other site
321314009818	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314009819	nucleotide binding region [chemical binding]; other site
321314009820	ATP-binding site [chemical binding]; other site
321314009821	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
321314009822	putative RNA binding site [nucleotide binding]; other site
321314009823	lipoprotein NlpI; Provisional; Region: PRK11189
321314009824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
321314009825	binding surface
321314009826	TPR motif; other site
321314009827	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
321314009828	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
321314009829	RNase E interface [polypeptide binding]; other site
321314009830	trimer interface [polypeptide binding]; other site
321314009831	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
321314009832	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
321314009833	RNase E interface [polypeptide binding]; other site
321314009834	trimer interface [polypeptide binding]; other site
321314009835	active site
321314009836	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
321314009837	putative nucleic acid binding region [nucleotide binding]; other site
321314009838	G-X-X-G motif; other site
321314009839	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
321314009840	RNA binding site [nucleotide binding]; other site
321314009841	domain interface; other site
321314009842	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
321314009843	16S/18S rRNA binding site [nucleotide binding]; other site
321314009844	S13e-L30e interaction site [polypeptide binding]; other site
321314009845	25S rRNA binding site [nucleotide binding]; other site
321314009846	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
321314009847	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
321314009848	RNA binding site [nucleotide binding]; other site
321314009849	active site
321314009850	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
321314009851	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
321314009852	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
321314009853	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
321314009854	translation initiation factor IF-2; Region: IF-2; TIGR00487
321314009855	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
321314009856	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
321314009857	G1 box; other site
321314009858	putative GEF interaction site [polypeptide binding]; other site
321314009859	GTP/Mg2+ binding site [chemical binding]; other site
321314009860	Switch I region; other site
321314009861	G2 box; other site
321314009862	G3 box; other site
321314009863	Switch II region; other site
321314009864	G4 box; other site
321314009865	G5 box; other site
321314009866	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
321314009867	Translation-initiation factor 2; Region: IF-2; pfam11987
321314009868	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
321314009869	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
321314009870	NusA N-terminal domain; Region: NusA_N; pfam08529
321314009871	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
321314009872	RNA binding site [nucleotide binding]; other site
321314009873	homodimer interface [polypeptide binding]; other site
321314009874	NusA-like KH domain; Region: KH_5; pfam13184
321314009875	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
321314009876	G-X-X-G motif; other site
321314009877	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
321314009878	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
321314009879	ribosome maturation protein RimP; Reviewed; Region: PRK00092
321314009880	Sm and related proteins; Region: Sm_like; cl00259
321314009881	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
321314009882	putative oligomer interface [polypeptide binding]; other site
321314009883	putative RNA binding site [nucleotide binding]; other site
321314009884	argininosuccinate synthase; Validated; Region: PRK05370
321314009885	argininosuccinate synthase; Provisional; Region: PRK13820
321314009886	Preprotein translocase SecG subunit; Region: SecG; pfam03840
321314009887	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
321314009888	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
321314009889	active site
321314009890	substrate binding site [chemical binding]; other site
321314009891	metal binding site [ion binding]; metal-binding site
321314009892	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
321314009893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314009894	Walker A motif; other site
321314009895	ATP binding site [chemical binding]; other site
321314009896	Walker B motif; other site
321314009897	arginine finger; other site
321314009898	Peptidase family M41; Region: Peptidase_M41; pfam01434
321314009899	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
321314009900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314009901	S-adenosylmethionine binding site [chemical binding]; other site
321314009902	RNA-binding protein YhbY; Provisional; Region: PRK10343
321314009903	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
321314009904	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
321314009905	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
321314009906	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
321314009907	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
321314009908	GTPase CgtA; Reviewed; Region: obgE; PRK12298
321314009909	GTP1/OBG; Region: GTP1_OBG; pfam01018
321314009910	Obg GTPase; Region: Obg; cd01898
321314009911	G1 box; other site
321314009912	GTP/Mg2+ binding site [chemical binding]; other site
321314009913	Switch I region; other site
321314009914	G2 box; other site
321314009915	G3 box; other site
321314009916	Switch II region; other site
321314009917	G4 box; other site
321314009918	G5 box; other site
321314009919	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
321314009920	EamA-like transporter family; Region: EamA; pfam00892
321314009921	EamA-like transporter family; Region: EamA; pfam00892
321314009922	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
321314009923	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
321314009924	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
321314009925	substrate binding pocket [chemical binding]; other site
321314009926	chain length determination region; other site
321314009927	substrate-Mg2+ binding site; other site
321314009928	catalytic residues [active]
321314009929	aspartate-rich region 1; other site
321314009930	active site lid residues [active]
321314009931	aspartate-rich region 2; other site
321314009932	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
321314009933	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
321314009934	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
321314009935	hinge; other site
321314009936	active site
321314009937	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
321314009938	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
321314009939	anti sigma factor interaction site; other site
321314009940	regulatory phosphorylation site [posttranslational modification]; other site
321314009941	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
321314009942	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
321314009943	mce related protein; Region: MCE; pfam02470
321314009944	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
321314009945	conserved hypothetical integral membrane protein; Region: TIGR00056
321314009946	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
321314009947	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
321314009948	Walker A/P-loop; other site
321314009949	ATP binding site [chemical binding]; other site
321314009950	Q-loop/lid; other site
321314009951	ABC transporter signature motif; other site
321314009952	Walker B; other site
321314009953	D-loop; other site
321314009954	H-loop/switch region; other site
321314009955	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
321314009956	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
321314009957	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
321314009958	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
321314009959	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
321314009960	putative active site [active]
321314009961	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
321314009962	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
321314009963	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
321314009964	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
321314009965	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
321314009966	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
321314009967	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
321314009968	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
321314009969	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
321314009970	Walker A/P-loop; other site
321314009971	ATP binding site [chemical binding]; other site
321314009972	Q-loop/lid; other site
321314009973	ABC transporter signature motif; other site
321314009974	Walker B; other site
321314009975	D-loop; other site
321314009976	H-loop/switch region; other site
321314009977	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
321314009978	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
321314009979	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
321314009980	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
321314009981	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
321314009982	30S subunit binding site; other site
321314009983	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314009984	active site
321314009985	phosphorylation site [posttranslational modification]
321314009986	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
321314009987	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
321314009988	dimerization domain swap beta strand [polypeptide binding]; other site
321314009989	regulatory protein interface [polypeptide binding]; other site
321314009990	active site
321314009991	regulatory phosphorylation site [posttranslational modification]; other site
321314009992	hypothetical protein; Provisional; Region: PRK10345
321314009993	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
321314009994	Transglycosylase; Region: Transgly; cl17702
321314009995	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
321314009996	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
321314009997	conserved cys residue [active]
321314009998	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
321314009999	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314010000	putative active site [active]
321314010001	heme pocket [chemical binding]; other site
321314010002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314010003	dimer interface [polypeptide binding]; other site
321314010004	phosphorylation site [posttranslational modification]
321314010005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314010006	ATP binding site [chemical binding]; other site
321314010007	Mg2+ binding site [ion binding]; other site
321314010008	G-X-G motif; other site
321314010009	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314010010	active site
321314010011	phosphorylation site [posttranslational modification]
321314010012	intermolecular recognition site; other site
321314010013	dimerization interface [polypeptide binding]; other site
321314010014	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
321314010015	putative binding surface; other site
321314010016	active site
321314010017	radical SAM protein, TIGR01212 family; Region: TIGR01212
321314010018	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314010019	FeS/SAM binding site; other site
321314010020	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
321314010021	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
321314010022	active site
321314010023	dimer interface [polypeptide binding]; other site
321314010024	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
321314010025	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
321314010026	active site
321314010027	FMN binding site [chemical binding]; other site
321314010028	substrate binding site [chemical binding]; other site
321314010029	3Fe-4S cluster binding site [ion binding]; other site
321314010030	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
321314010031	domain interface; other site
321314010032	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
321314010033	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314010034	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314010035	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
321314010036	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
321314010037	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
321314010038	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
321314010039	Na binding site [ion binding]; other site
321314010040	putative substrate binding site [chemical binding]; other site
321314010041	cytosine deaminase; Provisional; Region: PRK09230
321314010042	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
321314010043	active site
321314010044	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
321314010045	N-acetylmannosamine kinase; Provisional; Region: PRK05082
321314010046	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314010047	nucleotide binding site [chemical binding]; other site
321314010048	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
321314010049	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
321314010050	putative active site cavity [active]
321314010051	putative sialic acid transporter; Provisional; Region: PRK03893
321314010052	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314010053	putative substrate translocation pore; other site
321314010054	N-acetylneuraminate lyase; Provisional; Region: PRK04147
321314010055	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
321314010056	inhibitor site; inhibition site
321314010057	active site
321314010058	dimer interface [polypeptide binding]; other site
321314010059	catalytic residue [active]
321314010060	transcriptional regulator NanR; Provisional; Region: PRK03837
321314010061	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314010062	DNA-binding site [nucleotide binding]; DNA binding site
321314010063	FCD domain; Region: FCD; pfam07729
321314010064	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
321314010065	stringent starvation protein A; Provisional; Region: sspA; PRK09481
321314010066	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
321314010067	C-terminal domain interface [polypeptide binding]; other site
321314010068	putative GSH binding site (G-site) [chemical binding]; other site
321314010069	dimer interface [polypeptide binding]; other site
321314010070	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
321314010071	dimer interface [polypeptide binding]; other site
321314010072	N-terminal domain interface [polypeptide binding]; other site
321314010073	Family of unknown function (DUF695); Region: DUF695; pfam05117
321314010074	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
321314010075	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
321314010076	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
321314010077	23S rRNA interface [nucleotide binding]; other site
321314010078	L3 interface [polypeptide binding]; other site
321314010079	Predicted ATPase [General function prediction only]; Region: COG1485
321314010080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
321314010081	hypothetical protein; Provisional; Region: PRK11677
321314010082	serine endoprotease; Provisional; Region: PRK10139
321314010083	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
321314010084	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
321314010085	protein binding site [polypeptide binding]; other site
321314010086	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
321314010087	serine endoprotease; Provisional; Region: PRK10898
321314010088	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
321314010089	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
321314010090	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
321314010091	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
321314010092	oxaloacetate decarboxylase; Provisional; Region: PRK14040
321314010093	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
321314010094	active site
321314010095	catalytic residues [active]
321314010096	metal binding site [ion binding]; metal-binding site
321314010097	homodimer binding site [polypeptide binding]; other site
321314010098	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
321314010099	carboxyltransferase (CT) interaction site; other site
321314010100	biotinylation site [posttranslational modification]; other site
321314010101	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
321314010102	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
321314010103	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
321314010104	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
321314010105	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
321314010106	transmembrane helices; other site
321314010107	Transcriptional regulators [Transcription]; Region: GntR; COG1802
321314010108	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314010109	DNA-binding site [nucleotide binding]; DNA binding site
321314010110	FCD domain; Region: FCD; pfam07729
321314010111	Transcriptional regulators [Transcription]; Region: GntR; COG1802
321314010112	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314010113	DNA-binding site [nucleotide binding]; DNA binding site
321314010114	malate dehydrogenase; Provisional; Region: PRK05086
321314010115	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
321314010116	NAD binding site [chemical binding]; other site
321314010117	dimerization interface [polypeptide binding]; other site
321314010118	Substrate binding site [chemical binding]; other site
321314010119	arginine repressor; Provisional; Region: PRK05066
321314010120	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
321314010121	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
321314010122	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314010123	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314010124	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
321314010125	RNAase interaction site [polypeptide binding]; other site
321314010126	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
321314010127	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
321314010128	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
321314010129	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314010130	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314010131	efflux system membrane protein; Provisional; Region: PRK11594
321314010132	transcriptional regulator; Provisional; Region: PRK10632
321314010133	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314010134	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
321314010135	putative effector binding pocket; other site
321314010136	dimerization interface [polypeptide binding]; other site
321314010137	protease TldD; Provisional; Region: tldD; PRK10735
321314010138	hypothetical protein; Provisional; Region: PRK10899
321314010139	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
321314010140	ribonuclease G; Provisional; Region: PRK11712
321314010141	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
321314010142	homodimer interface [polypeptide binding]; other site
321314010143	oligonucleotide binding site [chemical binding]; other site
321314010144	Maf-like protein; Region: Maf; pfam02545
321314010145	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
321314010146	active site
321314010147	dimer interface [polypeptide binding]; other site
321314010148	rod shape-determining protein MreD; Provisional; Region: PRK11060
321314010149	rod shape-determining protein MreC; Region: mreC; TIGR00219
321314010150	rod shape-determining protein MreC; Region: MreC; pfam04085
321314010151	rod shape-determining protein MreB; Provisional; Region: PRK13927
321314010152	MreB and similar proteins; Region: MreB_like; cd10225
321314010153	nucleotide binding site [chemical binding]; other site
321314010154	Mg binding site [ion binding]; other site
321314010155	putative protofilament interaction site [polypeptide binding]; other site
321314010156	RodZ interaction site [polypeptide binding]; other site
321314010157	regulatory protein CsrD; Provisional; Region: PRK11059
321314010158	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314010159	metal binding site [ion binding]; metal-binding site
321314010160	active site
321314010161	I-site; other site
321314010162	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314010163	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
321314010164	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
321314010165	NADP binding site [chemical binding]; other site
321314010166	dimer interface [polypeptide binding]; other site
321314010167	TMAO/DMSO reductase; Reviewed; Region: PRK05363
321314010168	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
321314010169	Moco binding site; other site
321314010170	metal coordination site [ion binding]; other site
321314010171	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
321314010172	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
321314010173	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
321314010174	carboxyltransferase (CT) interaction site; other site
321314010175	biotinylation site [posttranslational modification]; other site
321314010176	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
321314010177	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
321314010178	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
321314010179	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
321314010180	hypothetical protein; Provisional; Region: PRK10633
321314010181	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
321314010182	Na binding site [ion binding]; other site
321314010183	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
321314010184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
321314010185	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
321314010186	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
321314010187	FMN binding site [chemical binding]; other site
321314010188	active site
321314010189	catalytic residues [active]
321314010190	substrate binding site [chemical binding]; other site
321314010191	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
321314010192	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
321314010193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314010194	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
321314010195	DNA methylase; Region: N6_N4_Mtase; pfam01555
321314010196	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
321314010197	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
321314010198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314010199	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
321314010200	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
321314010201	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
321314010202	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
321314010203	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
321314010204	trimer interface [polypeptide binding]; other site
321314010205	putative metal binding site [ion binding]; other site
321314010206	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
321314010207	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
321314010208	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
321314010209	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
321314010210	shikimate binding site; other site
321314010211	NAD(P) binding site [chemical binding]; other site
321314010212	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
321314010213	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
321314010214	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
321314010215	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
321314010216	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
321314010217	hypothetical protein; Validated; Region: PRK03430
321314010218	hypothetical protein; Provisional; Region: PRK10736
321314010219	DNA protecting protein DprA; Region: dprA; TIGR00732
321314010220	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
321314010221	active site
321314010222	catalytic residues [active]
321314010223	metal binding site [ion binding]; metal-binding site
321314010224	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
321314010225	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
321314010226	putative active site [active]
321314010227	substrate binding site [chemical binding]; other site
321314010228	putative cosubstrate binding site; other site
321314010229	catalytic site [active]
321314010230	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
321314010231	substrate binding site [chemical binding]; other site
321314010232	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
321314010233	putative RNA binding site [nucleotide binding]; other site
321314010234	16S rRNA methyltransferase B; Provisional; Region: PRK10901
321314010235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314010236	S-adenosylmethionine binding site [chemical binding]; other site
321314010237	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
321314010238	TrkA-N domain; Region: TrkA_N; pfam02254
321314010239	TrkA-C domain; Region: TrkA_C; pfam02080
321314010240	TrkA-N domain; Region: TrkA_N; pfam02254
321314010241	TrkA-C domain; Region: TrkA_C; pfam02080
321314010242	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
321314010243	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
321314010244	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
321314010245	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
321314010246	DNA binding residues [nucleotide binding]
321314010247	dimer interface [polypeptide binding]; other site
321314010248	metal binding site [ion binding]; metal-binding site
321314010249	hypothetical protein; Provisional; Region: PRK10203
321314010250	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
321314010251	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
321314010252	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
321314010253	alphaNTD homodimer interface [polypeptide binding]; other site
321314010254	alphaNTD - beta interaction site [polypeptide binding]; other site
321314010255	alphaNTD - beta' interaction site [polypeptide binding]; other site
321314010256	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
321314010257	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
321314010258	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
321314010259	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314010260	RNA binding surface [nucleotide binding]; other site
321314010261	30S ribosomal protein S11; Validated; Region: PRK05309
321314010262	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
321314010263	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
321314010264	SecY translocase; Region: SecY; pfam00344
321314010265	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
321314010266	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
321314010267	23S rRNA binding site [nucleotide binding]; other site
321314010268	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
321314010269	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
321314010270	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
321314010271	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
321314010272	23S rRNA interface [nucleotide binding]; other site
321314010273	5S rRNA interface [nucleotide binding]; other site
321314010274	L27 interface [polypeptide binding]; other site
321314010275	L5 interface [polypeptide binding]; other site
321314010276	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
321314010277	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
321314010278	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
321314010279	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
321314010280	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
321314010281	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
321314010282	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
321314010283	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
321314010284	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
321314010285	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
321314010286	RNA binding site [nucleotide binding]; other site
321314010287	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
321314010288	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
321314010289	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
321314010290	23S rRNA interface [nucleotide binding]; other site
321314010291	putative translocon interaction site; other site
321314010292	signal recognition particle (SRP54) interaction site; other site
321314010293	L23 interface [polypeptide binding]; other site
321314010294	trigger factor interaction site; other site
321314010295	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
321314010296	23S rRNA interface [nucleotide binding]; other site
321314010297	5S rRNA interface [nucleotide binding]; other site
321314010298	putative antibiotic binding site [chemical binding]; other site
321314010299	L25 interface [polypeptide binding]; other site
321314010300	L27 interface [polypeptide binding]; other site
321314010301	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
321314010302	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
321314010303	G-X-X-G motif; other site
321314010304	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
321314010305	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
321314010306	protein-rRNA interface [nucleotide binding]; other site
321314010307	putative translocon binding site; other site
321314010308	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
321314010309	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
321314010310	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
321314010311	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
321314010312	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
321314010313	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
321314010314	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
321314010315	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
321314010316	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
321314010317	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
321314010318	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
321314010319	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
321314010320	heme binding site [chemical binding]; other site
321314010321	ferroxidase pore; other site
321314010322	ferroxidase diiron center [ion binding]; other site
321314010323	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
321314010324	elongation factor Tu; Reviewed; Region: PRK00049
321314010325	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
321314010326	G1 box; other site
321314010327	GEF interaction site [polypeptide binding]; other site
321314010328	GTP/Mg2+ binding site [chemical binding]; other site
321314010329	Switch I region; other site
321314010330	G2 box; other site
321314010331	G3 box; other site
321314010332	Switch II region; other site
321314010333	G4 box; other site
321314010334	G5 box; other site
321314010335	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
321314010336	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
321314010337	Antibiotic Binding Site [chemical binding]; other site
321314010338	elongation factor G; Reviewed; Region: PRK00007
321314010339	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
321314010340	G1 box; other site
321314010341	putative GEF interaction site [polypeptide binding]; other site
321314010342	GTP/Mg2+ binding site [chemical binding]; other site
321314010343	Switch I region; other site
321314010344	G2 box; other site
321314010345	G3 box; other site
321314010346	Switch II region; other site
321314010347	G4 box; other site
321314010348	G5 box; other site
321314010349	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
321314010350	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
321314010351	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
321314010352	30S ribosomal protein S7; Validated; Region: PRK05302
321314010353	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
321314010354	S17 interaction site [polypeptide binding]; other site
321314010355	S8 interaction site; other site
321314010356	16S rRNA interaction site [nucleotide binding]; other site
321314010357	streptomycin interaction site [chemical binding]; other site
321314010358	23S rRNA interaction site [nucleotide binding]; other site
321314010359	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
321314010360	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
321314010361	sulfur relay protein TusC; Validated; Region: PRK00211
321314010362	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
321314010363	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
321314010364	YheO-like PAS domain; Region: PAS_6; pfam08348
321314010365	HTH domain; Region: HTH_22; pfam13309
321314010366	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
321314010367	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
321314010368	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
321314010369	phi X174 lysis protein; Provisional; Region: PRK02793
321314010370	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
321314010371	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
321314010372	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
321314010373	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
321314010374	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
321314010375	TrkA-N domain; Region: TrkA_N; pfam02254
321314010376	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
321314010377	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
321314010378	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314010379	Walker A/P-loop; other site
321314010380	ATP binding site [chemical binding]; other site
321314010381	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314010382	ABC transporter signature motif; other site
321314010383	Walker B; other site
321314010384	D-loop; other site
321314010385	ABC transporter; Region: ABC_tran_2; pfam12848
321314010386	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314010387	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314010388	putative monooxygenase; Provisional; Region: PRK11118
321314010389	putative hydrolase; Provisional; Region: PRK10985
321314010390	hypothetical protein; Provisional; Region: PRK04966
321314010391	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
321314010392	active site
321314010393	hypothetical protein; Provisional; Region: PRK10738
321314010394	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
321314010395	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
321314010396	ligand binding site [chemical binding]; other site
321314010397	flexible hinge region; other site
321314010398	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
321314010399	putative switch regulator; other site
321314010400	non-specific DNA interactions [nucleotide binding]; other site
321314010401	DNA binding site [nucleotide binding]
321314010402	sequence specific DNA binding site [nucleotide binding]; other site
321314010403	putative cAMP binding site [chemical binding]; other site
321314010404	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
321314010405	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
321314010406	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
321314010407	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
321314010408	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
321314010409	inhibitor-cofactor binding pocket; inhibition site
321314010410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314010411	catalytic residue [active]
321314010412	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
321314010413	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
321314010414	glutamine binding [chemical binding]; other site
321314010415	catalytic triad [active]
321314010416	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
321314010417	cell filamentation protein Fic; Provisional; Region: PRK10347
321314010418	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
321314010419	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
321314010420	substrate binding site [chemical binding]; other site
321314010421	putative transporter; Provisional; Region: PRK03699
321314010422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314010423	putative substrate translocation pore; other site
321314010424	nitrite reductase subunit NirD; Provisional; Region: PRK14989
321314010425	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314010426	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
321314010427	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
321314010428	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
321314010429	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
321314010430	nitrite transporter NirC; Provisional; Region: PRK11562
321314010431	siroheme synthase; Provisional; Region: cysG; PRK10637
321314010432	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
321314010433	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
321314010434	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
321314010435	active site
321314010436	SAM binding site [chemical binding]; other site
321314010437	homodimer interface [polypeptide binding]; other site
321314010438	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
321314010439	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
321314010440	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
321314010441	active site
321314010442	HIGH motif; other site
321314010443	dimer interface [polypeptide binding]; other site
321314010444	KMSKS motif; other site
321314010445	phosphoglycolate phosphatase; Provisional; Region: PRK13222
321314010446	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314010447	motif II; other site
321314010448	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
321314010449	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
321314010450	substrate binding site [chemical binding]; other site
321314010451	hexamer interface [polypeptide binding]; other site
321314010452	metal binding site [ion binding]; metal-binding site
321314010453	DNA adenine methylase; Provisional; Region: PRK10904
321314010454	cell division protein DamX; Validated; Region: PRK10905
321314010455	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
321314010456	active site
321314010457	dimer interface [polypeptide binding]; other site
321314010458	metal binding site [ion binding]; metal-binding site
321314010459	shikimate kinase; Reviewed; Region: aroK; PRK00131
321314010460	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
321314010461	ADP binding site [chemical binding]; other site
321314010462	magnesium binding site [ion binding]; other site
321314010463	putative shikimate binding site; other site
321314010464	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
321314010465	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
321314010466	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
321314010467	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
321314010468	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
321314010469	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
321314010470	Transglycosylase; Region: Transgly; pfam00912
321314010471	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
321314010472	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
321314010473	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
321314010474	ADP-ribose binding site [chemical binding]; other site
321314010475	dimer interface [polypeptide binding]; other site
321314010476	active site
321314010477	nudix motif; other site
321314010478	metal binding site [ion binding]; metal-binding site
321314010479	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
321314010480	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
321314010481	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314010482	motif II; other site
321314010483	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314010484	RNA binding surface [nucleotide binding]; other site
321314010485	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
321314010486	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
321314010487	dimerization interface [polypeptide binding]; other site
321314010488	domain crossover interface; other site
321314010489	redox-dependent activation switch; other site
321314010490	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
321314010491	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
321314010492	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
321314010493	active site
321314010494	substrate-binding site [chemical binding]; other site
321314010495	metal-binding site [ion binding]
321314010496	ATP binding site [chemical binding]; other site
321314010497	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
321314010498	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314010499	dimerization interface [polypeptide binding]; other site
321314010500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314010501	dimer interface [polypeptide binding]; other site
321314010502	phosphorylation site [posttranslational modification]
321314010503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314010504	ATP binding site [chemical binding]; other site
321314010505	G-X-G motif; other site
321314010506	osmolarity response regulator; Provisional; Region: ompR; PRK09468
321314010507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314010508	active site
321314010509	phosphorylation site [posttranslational modification]
321314010510	intermolecular recognition site; other site
321314010511	dimerization interface [polypeptide binding]; other site
321314010512	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314010513	DNA binding site [nucleotide binding]
321314010514	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
321314010515	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
321314010516	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
321314010517	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
321314010518	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
321314010519	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
321314010520	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
321314010521	RNA binding site [nucleotide binding]; other site
321314010522	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
321314010523	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
321314010524	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
321314010525	G1 box; other site
321314010526	GTP/Mg2+ binding site [chemical binding]; other site
321314010527	Switch I region; other site
321314010528	G2 box; other site
321314010529	G3 box; other site
321314010530	Switch II region; other site
321314010531	G4 box; other site
321314010532	G5 box; other site
321314010533	Nucleoside recognition; Region: Gate; pfam07670
321314010534	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
321314010535	Nucleoside recognition; Region: Gate; pfam07670
321314010536	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
321314010537	hypothetical protein; Provisional; Region: PRK09956
321314010538	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
321314010539	carboxylesterase BioH; Provisional; Region: PRK10349
321314010540	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
321314010541	DNA utilization protein GntX; Provisional; Region: PRK11595
321314010542	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314010543	active site
321314010544	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
321314010545	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
321314010546	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
321314010547	high-affinity gluconate transporter; Provisional; Region: PRK14984
321314010548	gluconate transporter; Region: gntP; TIGR00791
321314010549	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
321314010550	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
321314010551	maltodextrin phosphorylase; Provisional; Region: PRK14985
321314010552	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
321314010553	homodimer interface [polypeptide binding]; other site
321314010554	active site pocket [active]
321314010555	transcriptional regulator MalT; Provisional; Region: PRK04841
321314010556	AAA ATPase domain; Region: AAA_16; pfam13191
321314010557	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314010558	DNA binding residues [nucleotide binding]
321314010559	dimerization interface [polypeptide binding]; other site
321314010560	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
321314010561	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
321314010562	putative active site [active]
321314010563	adenylation catalytic residue [active]
321314010564	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
321314010565	hypothetical protein; Reviewed; Region: PRK09588
321314010566	TROVE domain; Region: TROVE; pfam05731
321314010567	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
321314010568	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
321314010569	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314010570	Walker A motif; other site
321314010571	ATP binding site [chemical binding]; other site
321314010572	Walker B motif; other site
321314010573	arginine finger; other site
321314010574	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
321314010575	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
321314010576	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314010577	intramembrane serine protease GlpG; Provisional; Region: PRK10907
321314010578	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
321314010579	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
321314010580	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
321314010581	active site residue [active]
321314010582	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
321314010583	hypothetical protein; Provisional; Region: PRK09781
321314010584	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
321314010585	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
321314010586	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
321314010587	dimer interface [polypeptide binding]; other site
321314010588	active site
321314010589	metal binding site [ion binding]; metal-binding site
321314010590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314010591	D-galactonate transporter; Region: 2A0114; TIGR00893
321314010592	putative substrate translocation pore; other site
321314010593	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
321314010594	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
321314010595	inhibitor site; inhibition site
321314010596	active site
321314010597	dimer interface [polypeptide binding]; other site
321314010598	catalytic residue [active]
321314010599	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
321314010600	Transcriptional regulator [Transcription]; Region: IclR; COG1414
321314010601	Bacterial transcriptional regulator; Region: IclR; pfam01614
321314010602	glycogen phosphorylase; Provisional; Region: PRK14986
321314010603	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
321314010604	homodimer interface [polypeptide binding]; other site
321314010605	active site pocket [active]
321314010606	glycogen synthase; Provisional; Region: glgA; PRK00654
321314010607	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
321314010608	ADP-binding pocket [chemical binding]; other site
321314010609	homodimer interface [polypeptide binding]; other site
321314010610	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
321314010611	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
321314010612	ligand binding site; other site
321314010613	oligomer interface; other site
321314010614	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
321314010615	dimer interface [polypeptide binding]; other site
321314010616	N-terminal domain interface [polypeptide binding]; other site
321314010617	sulfate 1 binding site; other site
321314010618	glycogen debranching enzyme; Provisional; Region: PRK03705
321314010619	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
321314010620	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
321314010621	active site
321314010622	catalytic site [active]
321314010623	glycogen branching enzyme; Provisional; Region: PRK05402
321314010624	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
321314010625	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
321314010626	active site
321314010627	catalytic site [active]
321314010628	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
321314010629	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
321314010630	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
321314010631	low affinity gluconate transporter; Provisional; Region: PRK10472
321314010632	gluconate transporter; Region: gntP; TIGR00791
321314010633	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
321314010634	ATP-binding site [chemical binding]; other site
321314010635	Gluconate-6-phosphate binding site [chemical binding]; other site
321314010636	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
321314010637	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314010638	DNA binding site [nucleotide binding]
321314010639	domain linker motif; other site
321314010640	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
321314010641	putative ligand binding site [chemical binding]; other site
321314010642	putative dimerization interface [polypeptide binding]; other site
321314010643	Pirin-related protein [General function prediction only]; Region: COG1741
321314010644	Pirin; Region: Pirin; pfam02678
321314010645	putative oxidoreductase; Provisional; Region: PRK10206
321314010646	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
321314010647	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
321314010648	putative acetyltransferase YhhY; Provisional; Region: PRK10140
321314010649	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314010650	Coenzyme A binding pocket [chemical binding]; other site
321314010651	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314010652	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
321314010653	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314010654	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
321314010655	substrate binding site [chemical binding]; other site
321314010656	dimer interface [polypeptide binding]; other site
321314010657	ATP binding site [chemical binding]; other site
321314010658	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
321314010659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
321314010660	Protein of unknown function, DUF606; Region: DUF606; pfam04657
321314010661	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
321314010662	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
321314010663	hypothetical protein; Provisional; Region: PRK10350
321314010664	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
321314010665	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
321314010666	putative active site [active]
321314010667	catalytic site [active]
321314010668	putative metal binding site [ion binding]; other site
321314010669	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
321314010670	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
321314010671	Walker A/P-loop; other site
321314010672	ATP binding site [chemical binding]; other site
321314010673	Q-loop/lid; other site
321314010674	ABC transporter signature motif; other site
321314010675	Walker B; other site
321314010676	D-loop; other site
321314010677	H-loop/switch region; other site
321314010678	TOBE domain; Region: TOBE_2; pfam08402
321314010679	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
321314010680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314010681	dimer interface [polypeptide binding]; other site
321314010682	conserved gate region; other site
321314010683	ABC-ATPase subunit interface; other site
321314010684	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
321314010685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314010686	putative PBP binding loops; other site
321314010687	dimer interface [polypeptide binding]; other site
321314010688	ABC-ATPase subunit interface; other site
321314010689	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
321314010690	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
321314010691	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
321314010692	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
321314010693	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
321314010694	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
321314010695	Walker A/P-loop; other site
321314010696	ATP binding site [chemical binding]; other site
321314010697	Q-loop/lid; other site
321314010698	ABC transporter signature motif; other site
321314010699	Walker B; other site
321314010700	D-loop; other site
321314010701	H-loop/switch region; other site
321314010702	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
321314010703	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
321314010704	Walker A/P-loop; other site
321314010705	ATP binding site [chemical binding]; other site
321314010706	Q-loop/lid; other site
321314010707	ABC transporter signature motif; other site
321314010708	Walker B; other site
321314010709	D-loop; other site
321314010710	H-loop/switch region; other site
321314010711	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
321314010712	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
321314010713	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
321314010714	TM-ABC transporter signature motif; other site
321314010715	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
321314010716	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
321314010717	TM-ABC transporter signature motif; other site
321314010718	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
321314010719	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
321314010720	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
321314010721	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
321314010722	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
321314010723	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
321314010724	dimerization interface [polypeptide binding]; other site
321314010725	ligand binding site [chemical binding]; other site
321314010726	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
321314010727	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
321314010728	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
321314010729	DNA binding residues [nucleotide binding]
321314010730	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
321314010731	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
321314010732	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314010733	Walker A/P-loop; other site
321314010734	ATP binding site [chemical binding]; other site
321314010735	ABC transporter; Region: ABC_tran; pfam00005
321314010736	Q-loop/lid; other site
321314010737	ABC transporter signature motif; other site
321314010738	Walker B; other site
321314010739	D-loop; other site
321314010740	H-loop/switch region; other site
321314010741	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
321314010742	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
321314010743	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
321314010744	P loop; other site
321314010745	GTP binding site [chemical binding]; other site
321314010746	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
321314010747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314010748	S-adenosylmethionine binding site [chemical binding]; other site
321314010749	hypothetical protein; Provisional; Region: PRK10910
321314010750	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
321314010751	Predicted membrane protein [Function unknown]; Region: COG3714
321314010752	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
321314010753	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
321314010754	metal-binding site [ion binding]
321314010755	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
321314010756	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
321314010757	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
321314010758	dimer interface [polypeptide binding]; other site
321314010759	ligand binding site [chemical binding]; other site
321314010760	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314010761	dimerization interface [polypeptide binding]; other site
321314010762	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314010763	dimer interface [polypeptide binding]; other site
321314010764	putative CheW interface [polypeptide binding]; other site
321314010765	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
321314010766	CPxP  motif; other site
321314010767	hypothetical protein; Provisional; Region: PRK11212
321314010768	hypothetical protein; Provisional; Region: PRK11615
321314010769	major facilitator superfamily transporter; Provisional; Region: PRK05122
321314010770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314010771	putative substrate translocation pore; other site
321314010772	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
321314010773	Domain of unknown function DUF20; Region: UPF0118; pfam01594
321314010774	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
321314010775	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
321314010776	nickel responsive regulator; Provisional; Region: PRK02967
321314010777	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
321314010778	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
321314010779	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
321314010780	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
321314010781	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
321314010782	Walker A/P-loop; other site
321314010783	ATP binding site [chemical binding]; other site
321314010784	Q-loop/lid; other site
321314010785	ABC transporter signature motif; other site
321314010786	Walker B; other site
321314010787	D-loop; other site
321314010788	H-loop/switch region; other site
321314010789	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
321314010790	Walker A/P-loop; other site
321314010791	ATP binding site [chemical binding]; other site
321314010792	Q-loop/lid; other site
321314010793	ABC transporter signature motif; other site
321314010794	Walker B; other site
321314010795	D-loop; other site
321314010796	H-loop/switch region; other site
321314010797	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
321314010798	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
321314010799	HlyD family secretion protein; Region: HlyD; pfam00529
321314010800	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314010801	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314010802	Predicted flavoproteins [General function prediction only]; Region: COG2081
321314010803	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314010804	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
321314010805	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
321314010806	universal stress protein UspB; Provisional; Region: PRK04960
321314010807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
321314010808	Ligand Binding Site [chemical binding]; other site
321314010809	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
321314010810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314010811	putative substrate translocation pore; other site
321314010812	POT family; Region: PTR2; pfam00854
321314010813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314010814	S-adenosylmethionine binding site [chemical binding]; other site
321314010815	oligopeptidase A; Provisional; Region: PRK10911
321314010816	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
321314010817	active site
321314010818	Zn binding site [ion binding]; other site
321314010819	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
321314010820	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
321314010821	active site
321314010822	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
321314010823	glutathione reductase; Validated; Region: PRK06116
321314010824	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
321314010825	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314010826	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
321314010827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314010828	Major Facilitator Superfamily; Region: MFS_1; pfam07690
321314010829	putative substrate translocation pore; other site
321314010830	polyol permease family; Region: 2A0118; TIGR00897
321314010831	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
321314010832	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
321314010833	DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337
321314010834	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
321314010835	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
321314010836	putative active site [active]
321314010837	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314010838	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
321314010839	substrate binding site [chemical binding]; other site
321314010840	dimer interface [polypeptide binding]; other site
321314010841	ATP binding site [chemical binding]; other site
321314010842	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
321314010843	active site
321314010844	homodimer interface [polypeptide binding]; other site
321314010845	homotetramer interface [polypeptide binding]; other site
321314010846	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
321314010847	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
321314010848	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
321314010849	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314010850	substrate binding site [chemical binding]; other site
321314010851	ATP binding site [chemical binding]; other site
321314010852	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
321314010853	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
321314010854	putative active site [active]
321314010855	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
321314010856	dimer interface [polypeptide binding]; other site
321314010857	active site
321314010858	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
321314010859	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314010860	DNA-binding site [nucleotide binding]; DNA binding site
321314010861	UTRA domain; Region: UTRA; pfam07702
321314010862	trehalase; Provisional; Region: treF; PRK13270
321314010863	Trehalase; Region: Trehalase; pfam01204
321314010864	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
321314010865	catalytic residue [active]
321314010866	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
321314010867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
321314010868	active site
321314010869	phosphorylation site [posttranslational modification]
321314010870	dimerization interface [polypeptide binding]; other site
321314010871	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314010872	DNA binding residues [nucleotide binding]
321314010873	dimerization interface [polypeptide binding]; other site
321314010874	similar to Tn10
321314010875	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
321314010876	inner membrane protein YhjD; Region: TIGR00766
321314010877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314010878	metabolite-proton symporter; Region: 2A0106; TIGR00883
321314010879	putative substrate translocation pore; other site
321314010880	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
321314010881	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
321314010882	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314010883	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314010884	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
321314010885	substrate binding site [chemical binding]; other site
321314010886	ATP binding site [chemical binding]; other site
321314010887	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
321314010888	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
321314010889	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
321314010890	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
321314010891	putative diguanylate cyclase; Provisional; Region: PRK13561
321314010892	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314010893	metal binding site [ion binding]; metal-binding site
321314010894	active site
321314010895	I-site; other site
321314010896	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314010897	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
321314010898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
321314010899	TPR motif; other site
321314010900	binding surface
321314010901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
321314010902	TPR motif; other site
321314010903	binding surface
321314010904	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
321314010905	binding surface
321314010906	TPR motif; other site
321314010907	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
321314010908	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
321314010909	Protein of unknown function (DUF3260); Region: DUF3260; cl11881
321314010910	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
321314010911	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
321314010912	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
321314010913	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
321314010914	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
321314010915	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
321314010916	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314010917	Walker A/P-loop; other site
321314010918	ATP binding site [chemical binding]; other site
321314010919	Q-loop/lid; other site
321314010920	ABC transporter signature motif; other site
321314010921	Walker B; other site
321314010922	D-loop; other site
321314010923	H-loop/switch region; other site
321314010924	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
321314010925	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
321314010926	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
321314010927	Walker A/P-loop; other site
321314010928	ATP binding site [chemical binding]; other site
321314010929	Q-loop/lid; other site
321314010930	ABC transporter signature motif; other site
321314010931	Walker B; other site
321314010932	D-loop; other site
321314010933	H-loop/switch region; other site
321314010934	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
321314010935	dipeptide transporter; Provisional; Region: PRK10913
321314010936	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
321314010937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314010938	dimer interface [polypeptide binding]; other site
321314010939	conserved gate region; other site
321314010940	putative PBP binding loops; other site
321314010941	ABC-ATPase subunit interface; other site
321314010942	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
321314010943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314010944	dimer interface [polypeptide binding]; other site
321314010945	conserved gate region; other site
321314010946	putative PBP binding loops; other site
321314010947	ABC-ATPase subunit interface; other site
321314010948	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
321314010949	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
321314010950	peptide binding site [polypeptide binding]; other site
321314010951	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
321314010952	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
321314010953	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
321314010954	Transcriptional regulators [Transcription]; Region: PurR; COG1609
321314010955	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314010956	DNA binding site [nucleotide binding]
321314010957	domain linker motif; other site
321314010958	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
321314010959	putative dimerization interface [polypeptide binding]; other site
321314010960	putative ligand binding site [chemical binding]; other site
321314010961	phosphoethanolamine transferase; Provisional; Region: PRK11560
321314010962	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
321314010963	Sulfatase; Region: Sulfatase; pfam00884
321314010964	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
321314010965	long polar fimbrial protein LpfD; Provisional; Region: PRK15206
321314010966	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
321314010967	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314010968	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314010969	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
321314010970	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
321314010971	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
321314010972	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314010973	Coenzyme A binding pocket [chemical binding]; other site
321314010974	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
321314010975	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
321314010976	molybdopterin cofactor binding site [chemical binding]; other site
321314010977	substrate binding site [chemical binding]; other site
321314010978	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
321314010979	molybdopterin cofactor binding site; other site
321314010980	putative outer membrane lipoprotein; Provisional; Region: PRK10510
321314010981	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
321314010982	ligand binding site [chemical binding]; other site
321314010983	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
321314010984	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
321314010985	dimerization interface [polypeptide binding]; other site
321314010986	ligand binding site [chemical binding]; other site
321314010987	NADP binding site [chemical binding]; other site
321314010988	catalytic site [active]
321314010989	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
321314010990	Predicted transcriptional regulator [Transcription]; Region: COG2944
321314010991	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314010992	salt bridge; other site
321314010993	non-specific DNA binding site [nucleotide binding]; other site
321314010994	sequence-specific DNA binding site [nucleotide binding]; other site
321314010995	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
321314010996	DNA-binding site [nucleotide binding]; DNA binding site
321314010997	RNA-binding motif; other site
321314010998	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314010999	Integrase core domain; Region: rve; pfam00665
321314011000	Integrase core domain; Region: rve_3; pfam13683
321314011001	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
321314011002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
321314011003	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
321314011004	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314011005	Coenzyme A binding pocket [chemical binding]; other site
321314011006	Integrase core domain; Region: rve; pfam00665
321314011007	Integrase core domain; Region: rve_2; pfam13333
321314011008	similar to Tn10
321314011009	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
321314011010	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
321314011011	DALR anticodon binding domain; Region: DALR_1; pfam05746
321314011012	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
321314011013	dimer interface [polypeptide binding]; other site
321314011014	motif 1; other site
321314011015	active site
321314011016	motif 2; other site
321314011017	motif 3; other site
321314011018	YsaB-like lipoprotein; Region: YsaB; pfam13983
321314011019	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
321314011020	Acyltransferase family; Region: Acyl_transf_3; pfam01757
321314011021	Predicted membrane protein [Function unknown]; Region: COG4682
321314011022	yiaA/B two helix domain; Region: YiaAB; pfam05360
321314011023	yiaA/B two helix domain; Region: YiaAB; pfam05360
321314011024	xylulokinase; Provisional; Region: PRK15027
321314011025	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
321314011026	N- and C-terminal domain interface [polypeptide binding]; other site
321314011027	active site
321314011028	MgATP binding site [chemical binding]; other site
321314011029	catalytic site [active]
321314011030	metal binding site [ion binding]; metal-binding site
321314011031	xylulose binding site [chemical binding]; other site
321314011032	homodimer interface [polypeptide binding]; other site
321314011033	xylose isomerase; Provisional; Region: PRK05474
321314011034	xylose isomerase; Region: xylose_isom_A; TIGR02630
321314011035	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
321314011036	putative dimerization interface [polypeptide binding]; other site
321314011037	Transcriptional regulators [Transcription]; Region: PurR; COG1609
321314011038	putative ligand binding site [chemical binding]; other site
321314011039	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314011040	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314011041	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314011042	hypothetical protein; Provisional; Region: PRK10356
321314011043	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
321314011044	alpha-amylase; Reviewed; Region: malS; PRK09505
321314011045	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
321314011046	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
321314011047	active site
321314011048	dimer interface [polypeptide binding]; other site
321314011049	magnesium binding site [ion binding]; other site
321314011050	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
321314011051	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
321314011052	AP (apurinic/apyrimidinic) site pocket; other site
321314011053	DNA interaction; other site
321314011054	Metal-binding active site; metal-binding site
321314011055	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
321314011056	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
321314011057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314011058	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
321314011059	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
321314011060	NAD(P) binding site [chemical binding]; other site
321314011061	catalytic residues [active]
321314011062	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
321314011063	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
321314011064	nucleotide binding site [chemical binding]; other site
321314011065	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
321314011066	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
321314011067	G1 box; other site
321314011068	putative GEF interaction site [polypeptide binding]; other site
321314011069	GTP/Mg2+ binding site [chemical binding]; other site
321314011070	Switch I region; other site
321314011071	G2 box; other site
321314011072	G3 box; other site
321314011073	Switch II region; other site
321314011074	G4 box; other site
321314011075	G5 box; other site
321314011076	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
321314011077	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
321314011078	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
321314011079	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
321314011080	selenocysteine synthase; Provisional; Region: PRK04311
321314011081	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
321314011082	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
321314011083	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314011084	catalytic residue [active]
321314011085	putative glutathione S-transferase; Provisional; Region: PRK10357
321314011086	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
321314011087	putative C-terminal domain interface [polypeptide binding]; other site
321314011088	putative GSH binding site (G-site) [chemical binding]; other site
321314011089	putative dimer interface [polypeptide binding]; other site
321314011090	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
321314011091	dimer interface [polypeptide binding]; other site
321314011092	N-terminal domain interface [polypeptide binding]; other site
321314011093	putative substrate binding pocket (H-site) [chemical binding]; other site
321314011094	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
321314011095	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
321314011096	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
321314011097	active site
321314011098	P-loop; other site
321314011099	phosphorylation site [posttranslational modification]
321314011100	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314011101	active site
321314011102	phosphorylation site [posttranslational modification]
321314011103	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
321314011104	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
321314011105	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
321314011106	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
321314011107	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
321314011108	hypothetical protein; Provisional; Region: PRK11020
321314011109	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
321314011110	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
321314011111	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
321314011112	trimer interface [polypeptide binding]; other site
321314011113	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
321314011114	Haemagglutinin; Region: HIM; pfam05662
321314011115	Haemagglutinin; Region: HIM; pfam05662
321314011116	YadA-like C-terminal region; Region: YadA; pfam03895
321314011117	L-lactate permease; Provisional; Region: PRK10420
321314011118	glycolate transporter; Provisional; Region: PRK09695
321314011119	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
321314011120	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314011121	DNA-binding site [nucleotide binding]; DNA binding site
321314011122	FCD domain; Region: FCD; pfam07729
321314011123	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
321314011124	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
321314011125	active site
321314011126	substrate binding site [chemical binding]; other site
321314011127	FMN binding site [chemical binding]; other site
321314011128	putative catalytic residues [active]
321314011129	putative rRNA methylase; Provisional; Region: PRK10358
321314011130	Transcriptional regulators [Transcription]; Region: PurR; COG1609
321314011131	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314011132	DNA binding site [nucleotide binding]
321314011133	domain linker motif; other site
321314011134	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
321314011135	putative dimerization interface [polypeptide binding]; other site
321314011136	putative ligand binding site [chemical binding]; other site
321314011137	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
321314011138	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
321314011139	active site pocket [active]
321314011140	serine acetyltransferase; Provisional; Region: cysE; PRK11132
321314011141	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
321314011142	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
321314011143	trimer interface [polypeptide binding]; other site
321314011144	active site
321314011145	substrate binding site [chemical binding]; other site
321314011146	CoA binding site [chemical binding]; other site
321314011147	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
321314011148	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
321314011149	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
321314011150	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
321314011151	SecA binding site; other site
321314011152	Preprotein binding site; other site
321314011153	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
321314011154	GSH binding site [chemical binding]; other site
321314011155	catalytic residues [active]
321314011156	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
321314011157	active site residue [active]
321314011158	phosphoglyceromutase; Provisional; Region: PRK05434
321314011159	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
321314011160	AmiB activator; Provisional; Region: PRK11637
321314011161	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
321314011162	Peptidase family M23; Region: Peptidase_M23; pfam01551
321314011163	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
321314011164	NodB motif; other site
321314011165	putative active site [active]
321314011166	putative catalytic site [active]
321314011167	Zn binding site [ion binding]; other site
321314011168	putative glycosyl transferase; Provisional; Region: PRK10073
321314011169	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
321314011170	active site
321314011171	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
321314011172	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
321314011173	NAD(P) binding site [chemical binding]; other site
321314011174	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
321314011175	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
321314011176	substrate-cofactor binding pocket; other site
321314011177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314011178	catalytic residue [active]
321314011179	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
321314011180	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
321314011181	NADP binding site [chemical binding]; other site
321314011182	homopentamer interface [polypeptide binding]; other site
321314011183	substrate binding site [chemical binding]; other site
321314011184	active site
321314011185	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
321314011186	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
321314011187	putative active site [active]
321314011188	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
321314011189	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
321314011190	putative active site [active]
321314011191	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
321314011192	O-antigen ligase RfaL; Provisional; Region: PRK15487
321314011193	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
321314011194	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
321314011195	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
321314011196	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
321314011197	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
321314011198	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
321314011199	Ligand binding site; other site
321314011200	metal-binding site
321314011201	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
321314011202	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
321314011203	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
321314011204	Ligand binding site; other site
321314011205	metal-binding site
321314011206	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
321314011207	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
321314011208	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
321314011209	putative ADP-binding pocket [chemical binding]; other site
321314011210	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
321314011211	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
321314011212	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
321314011213	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
321314011214	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
321314011215	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
321314011216	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
321314011217	putative active site [active]
321314011218	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
321314011219	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
321314011220	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
321314011221	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
321314011222	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
321314011223	active site
321314011224	(T/H)XGH motif; other site
321314011225	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
321314011226	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
321314011227	DNA binding site [nucleotide binding]
321314011228	catalytic residue [active]
321314011229	H2TH interface [polypeptide binding]; other site
321314011230	putative catalytic residues [active]
321314011231	turnover-facilitating residue; other site
321314011232	intercalation triad [nucleotide binding]; other site
321314011233	8OG recognition residue [nucleotide binding]; other site
321314011234	putative reading head residues; other site
321314011235	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
321314011236	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
321314011237	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
321314011238	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
321314011239	hypothetical protein; Reviewed; Region: PRK00024
321314011240	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
321314011241	MPN+ (JAMM) motif; other site
321314011242	Zinc-binding site [ion binding]; other site
321314011243	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
321314011244	Flavoprotein; Region: Flavoprotein; pfam02441
321314011245	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
321314011246	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
321314011247	trimer interface [polypeptide binding]; other site
321314011248	active site
321314011249	division inhibitor protein; Provisional; Region: slmA; PRK09480
321314011250	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314011251	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
321314011252	active site
321314011253	ribonuclease PH; Reviewed; Region: rph; PRK00173
321314011254	Ribonuclease PH; Region: RNase_PH_bact; cd11362
321314011255	hexamer interface [polypeptide binding]; other site
321314011256	active site
321314011257	hypothetical protein; Provisional; Region: PRK11820
321314011258	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
321314011259	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
321314011260	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314011261	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314011262	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
321314011263	dimerization interface [polypeptide binding]; other site
321314011264	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
321314011265	Predicted membrane protein [Function unknown]; Region: COG2860
321314011266	UPF0126 domain; Region: UPF0126; pfam03458
321314011267	UPF0126 domain; Region: UPF0126; pfam03458
321314011268	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
321314011269	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
321314011270	nucleotide binding pocket [chemical binding]; other site
321314011271	K-X-D-G motif; other site
321314011272	catalytic site [active]
321314011273	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
321314011274	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
321314011275	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
321314011276	catalytic site [active]
321314011277	G-X2-G-X-G-K; other site
321314011278	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
321314011279	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
321314011280	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
321314011281	Zn2+ binding site [ion binding]; other site
321314011282	Mg2+ binding site [ion binding]; other site
321314011283	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
321314011284	synthetase active site [active]
321314011285	NTP binding site [chemical binding]; other site
321314011286	metal binding site [ion binding]; metal-binding site
321314011287	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
321314011288	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
321314011289	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
321314011290	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
321314011291	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
321314011292	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
321314011293	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
321314011294	generic binding surface II; other site
321314011295	ssDNA binding site; other site
321314011296	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314011297	ATP binding site [chemical binding]; other site
321314011298	putative Mg++ binding site [ion binding]; other site
321314011299	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314011300	nucleotide binding region [chemical binding]; other site
321314011301	ATP-binding site [chemical binding]; other site
321314011302	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
321314011303	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
321314011304	AsmA family; Region: AsmA; pfam05170
321314011305	putative alpha-glucosidase; Provisional; Region: PRK10658
321314011306	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
321314011307	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
321314011308	active site
321314011309	homotrimer interface [polypeptide binding]; other site
321314011310	catalytic site [active]
321314011311	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
321314011312	putative transporter; Provisional; Region: PRK11462
321314011313	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
321314011314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
321314011315	Transposase; Region: HTH_Tnp_1; cl17663
321314011316	Transposase; Region: HTH_Tnp_1; cl17663
321314011317	autotransport protein MisL; Provisional; Region: PRK15313
321314011318	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
321314011319	Autotransporter beta-domain; Region: Autotransporter; pfam03797
321314011320	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
321314011321	DNA binding site [nucleotide binding]
321314011322	Isochorismatase family; Region: Isochorismatase; pfam00857
321314011323	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
321314011324	catalytic triad [active]
321314011325	dimer interface [polypeptide binding]; other site
321314011326	conserved cis-peptide bond; other site
321314011327	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
321314011328	magnesium-transporting ATPase; Provisional; Region: PRK15122
321314011329	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
321314011330	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
321314011331	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
321314011332	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314011333	motif II; other site
321314011334	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
321314011335	magnesium transport protein MgtC; Provisional; Region: PRK15385
321314011336	MgtC family; Region: MgtC; pfam02308
321314011337	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
321314011338	EamA-like transporter family; Region: EamA; pfam00892
321314011339	EamA-like transporter family; Region: EamA; pfam00892
321314011340	hypothetical protein; Provisional; Region: PRK09956
321314011341	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
321314011342	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
321314011343	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
321314011344	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
321314011345	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
321314011346	active site
321314011347	phosphorylation site [posttranslational modification]
321314011348	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
321314011349	active pocket/dimerization site; other site
321314011350	active site
321314011351	phosphorylation site [posttranslational modification]
321314011352	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
321314011353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314011354	Walker A motif; other site
321314011355	ATP binding site [chemical binding]; other site
321314011356	Walker B motif; other site
321314011357	arginine finger; other site
321314011358	Transcriptional antiterminator [Transcription]; Region: COG3933
321314011359	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
321314011360	active site
321314011361	active pocket/dimerization site; other site
321314011362	phosphorylation site [posttranslational modification]
321314011363	PRD domain; Region: PRD; pfam00874
321314011364	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
321314011365	beta-galactosidase; Region: BGL; TIGR03356
321314011366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
321314011367	Predicted transcriptional regulator [Transcription]; Region: COG2944
321314011368	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314011369	non-specific DNA binding site [nucleotide binding]; other site
321314011370	salt bridge; other site
321314011371	sequence-specific DNA binding site [nucleotide binding]; other site
321314011372	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
321314011373	GIY-YIG motif/motif A; other site
321314011374	putative active site [active]
321314011375	putative metal binding site [ion binding]; other site
321314011376	similar to IS285
321314011377	similar to IS285
321314011378	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
321314011379	dimerization domain swap beta strand [polypeptide binding]; other site
321314011380	regulatory protein interface [polypeptide binding]; other site
321314011381	active site
321314011382	regulatory phosphorylation site [posttranslational modification]; other site
321314011383	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
321314011384	intersubunit interface [polypeptide binding]; other site
321314011385	active site
321314011386	zinc binding site [ion binding]; other site
321314011387	Na+ binding site [ion binding]; other site
321314011388	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
321314011389	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
321314011390	putative N- and C-terminal domain interface [polypeptide binding]; other site
321314011391	putative active site [active]
321314011392	putative MgATP binding site [chemical binding]; other site
321314011393	catalytic site [active]
321314011394	metal binding site [ion binding]; metal-binding site
321314011395	putative carbohydrate binding site [chemical binding]; other site
321314011396	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
321314011397	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
321314011398	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
321314011399	active site
321314011400	P-loop; other site
321314011401	phosphorylation site [posttranslational modification]
321314011402	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314011403	active site
321314011404	phosphorylation site [posttranslational modification]
321314011405	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
321314011406	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314011407	DNA-binding site [nucleotide binding]; DNA binding site
321314011408	UTRA domain; Region: UTRA; pfam07702
321314011409	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
321314011410	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
321314011411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011412	putative substrate translocation pore; other site
321314011413	sensory histidine kinase UhpB; Provisional; Region: PRK11644
321314011414	MASE1; Region: MASE1; pfam05231
321314011415	Histidine kinase; Region: HisKA_3; pfam07730
321314011416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314011417	ATP binding site [chemical binding]; other site
321314011418	Mg2+ binding site [ion binding]; other site
321314011419	G-X-G motif; other site
321314011420	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
321314011421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314011422	active site
321314011423	phosphorylation site [posttranslational modification]
321314011424	intermolecular recognition site; other site
321314011425	dimerization interface [polypeptide binding]; other site
321314011426	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314011427	DNA binding residues [nucleotide binding]
321314011428	dimerization interface [polypeptide binding]; other site
321314011429	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
321314011430	active site
321314011431	catalytic residues [active]
321314011432	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
321314011433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011434	putative substrate translocation pore; other site
321314011435	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314011436	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
321314011437	substrate binding site [chemical binding]; other site
321314011438	dimer interface [polypeptide binding]; other site
321314011439	ATP binding site [chemical binding]; other site
321314011440	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
321314011441	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
321314011442	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314011443	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
321314011444	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
321314011445	putative valine binding site [chemical binding]; other site
321314011446	dimer interface [polypeptide binding]; other site
321314011447	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
321314011448	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
321314011449	PYR/PP interface [polypeptide binding]; other site
321314011450	dimer interface [polypeptide binding]; other site
321314011451	TPP binding site [chemical binding]; other site
321314011452	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
321314011453	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
321314011454	TPP-binding site [chemical binding]; other site
321314011455	dimer interface [polypeptide binding]; other site
321314011456	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
321314011457	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
321314011458	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
321314011459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011460	putative substrate translocation pore; other site
321314011461	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
321314011462	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
321314011463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314011464	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
321314011465	dimerization interface [polypeptide binding]; other site
321314011466	substrate binding pocket [chemical binding]; other site
321314011467	permease DsdX; Provisional; Region: PRK09921
321314011468	gluconate transporter; Region: gntP; TIGR00791
321314011469	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
321314011470	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
321314011471	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
321314011472	catalytic residue [active]
321314011473	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
321314011474	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
321314011475	Domain of unknown function (DUF202); Region: DUF202; pfam02656
321314011476	Predicted membrane protein [Function unknown]; Region: COG2149
321314011477	putative transporter; Validated; Region: PRK03818
321314011478	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
321314011479	TrkA-C domain; Region: TrkA_C; pfam02080
321314011480	TrkA-C domain; Region: TrkA_C; pfam02080
321314011481	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
321314011482	Integrase core domain; Region: rve; pfam00665
321314011483	Integrase core domain; Region: rve_3; pfam13683
321314011484	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314011485	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
321314011486	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
321314011487	putative dimer interface [polypeptide binding]; other site
321314011488	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
321314011489	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
321314011490	putative dimer interface [polypeptide binding]; other site
321314011491	hypothetical protein; Provisional; Region: PRK11616
321314011492	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
321314011493	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
321314011494	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
321314011495	catalytic residues [active]
321314011496	central insert; other site
321314011497	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
321314011498	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314011499	Walker A/P-loop; other site
321314011500	ATP binding site [chemical binding]; other site
321314011501	Q-loop/lid; other site
321314011502	ABC transporter signature motif; other site
321314011503	Walker B; other site
321314011504	D-loop; other site
321314011505	H-loop/switch region; other site
321314011506	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
321314011507	Haem-binding domain; Region: Haem_bd; pfam14376
321314011508	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
321314011509	chaperone protein TorD; Validated; Region: torD; PRK04976
321314011510	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
321314011511	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
321314011512	molybdopterin cofactor binding site [chemical binding]; other site
321314011513	substrate binding site [chemical binding]; other site
321314011514	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
321314011515	molybdopterin cofactor binding site; other site
321314011516	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
321314011517	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
321314011518	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
321314011519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314011520	active site
321314011521	phosphorylation site [posttranslational modification]
321314011522	intermolecular recognition site; other site
321314011523	dimerization interface [polypeptide binding]; other site
321314011524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314011525	DNA binding site [nucleotide binding]
321314011526	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
321314011527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314011528	dimer interface [polypeptide binding]; other site
321314011529	phosphorylation site [posttranslational modification]
321314011530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314011531	ATP binding site [chemical binding]; other site
321314011532	Mg2+ binding site [ion binding]; other site
321314011533	G-X-G motif; other site
321314011534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314011535	active site
321314011536	phosphorylation site [posttranslational modification]
321314011537	intermolecular recognition site; other site
321314011538	dimerization interface [polypeptide binding]; other site
321314011539	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
321314011540	putative binding surface; other site
321314011541	active site
321314011542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011543	D-galactonate transporter; Region: 2A0114; TIGR00893
321314011544	putative substrate translocation pore; other site
321314011545	galactonate dehydratase; Provisional; Region: PRK14017
321314011546	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
321314011547	putative active site pocket [active]
321314011548	putative metal binding site [ion binding]; other site
321314011549	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
321314011550	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
321314011551	active site
321314011552	intersubunit interface [polypeptide binding]; other site
321314011553	catalytic residue [active]
321314011554	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
321314011555	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
321314011556	Transcriptional regulators [Transcription]; Region: FadR; COG2186
321314011557	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314011558	DNA-binding site [nucleotide binding]; DNA binding site
321314011559	FCD domain; Region: FCD; pfam07729
321314011560	sugar phosphate phosphatase; Provisional; Region: PRK10513
321314011561	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314011562	active site
321314011563	motif I; other site
321314011564	motif II; other site
321314011565	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314011566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011567	D-galactonate transporter; Region: 2A0114; TIGR00893
321314011568	putative substrate translocation pore; other site
321314011569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011570	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
321314011571	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
321314011572	active site pocket [active]
321314011573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314011574	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
321314011575	putative dimerization interface [polypeptide binding]; other site
321314011576	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
321314011577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314011578	Mg2+ binding site [ion binding]; other site
321314011579	G-X-G motif; other site
321314011580	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
321314011581	anchoring element; other site
321314011582	dimer interface [polypeptide binding]; other site
321314011583	ATP binding site [chemical binding]; other site
321314011584	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
321314011585	active site
321314011586	putative metal-binding site [ion binding]; other site
321314011587	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
321314011588	recF protein; Region: recf; TIGR00611
321314011589	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314011590	Walker A/P-loop; other site
321314011591	ATP binding site [chemical binding]; other site
321314011592	Q-loop/lid; other site
321314011593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314011594	ABC transporter signature motif; other site
321314011595	Walker B; other site
321314011596	D-loop; other site
321314011597	H-loop/switch region; other site
321314011598	DNA polymerase III subunit beta; Validated; Region: PRK05643
321314011599	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
321314011600	putative DNA binding surface [nucleotide binding]; other site
321314011601	dimer interface [polypeptide binding]; other site
321314011602	beta-clamp/clamp loader binding surface; other site
321314011603	beta-clamp/translesion DNA polymerase binding surface; other site
321314011604	DnaA N-terminal domain; Region: DnaA_N; pfam11638
321314011605	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
321314011606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314011607	Walker A motif; other site
321314011608	ATP binding site [chemical binding]; other site
321314011609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
321314011610	Walker B motif; other site
321314011611	arginine finger; other site
321314011612	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
321314011613	DnaA box-binding interface [nucleotide binding]; other site
321314011614	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
321314011615	ribonuclease P; Reviewed; Region: rnpA; PRK01732
321314011616	membrane protein insertase; Provisional; Region: PRK01318
321314011617	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
321314011618	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
321314011619	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
321314011620	trmE is a tRNA modification GTPase; Region: trmE; cd04164
321314011621	G1 box; other site
321314011622	GTP/Mg2+ binding site [chemical binding]; other site
321314011623	Switch I region; other site
321314011624	G2 box; other site
321314011625	Switch II region; other site
321314011626	G3 box; other site
321314011627	G4 box; other site
321314011628	G5 box; other site
321314011629	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
321314011630	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
321314011631	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011632	putative substrate translocation pore; other site
321314011633	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
321314011634	Predicted flavoprotein [General function prediction only]; Region: COG0431
321314011635	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
321314011636	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
321314011637	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
321314011638	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314011639	active site
321314011640	motif I; other site
321314011641	motif II; other site
321314011642	transcriptional regulator PhoU; Provisional; Region: PRK11115
321314011643	PhoU domain; Region: PhoU; pfam01895
321314011644	PhoU domain; Region: PhoU; pfam01895
321314011645	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
321314011646	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
321314011647	Walker A/P-loop; other site
321314011648	ATP binding site [chemical binding]; other site
321314011649	Q-loop/lid; other site
321314011650	ABC transporter signature motif; other site
321314011651	Walker B; other site
321314011652	D-loop; other site
321314011653	H-loop/switch region; other site
321314011654	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
321314011655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314011656	dimer interface [polypeptide binding]; other site
321314011657	conserved gate region; other site
321314011658	putative PBP binding loops; other site
321314011659	ABC-ATPase subunit interface; other site
321314011660	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
321314011661	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314011662	dimer interface [polypeptide binding]; other site
321314011663	conserved gate region; other site
321314011664	putative PBP binding loops; other site
321314011665	ABC-ATPase subunit interface; other site
321314011666	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314011667	substrate binding pocket [chemical binding]; other site
321314011668	membrane-bound complex binding site; other site
321314011669	hinge residues; other site
321314011670	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
321314011671	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
321314011672	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
321314011673	shikimate binding site; other site
321314011674	NAD(P) binding site [chemical binding]; other site
321314011675	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
321314011676	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
321314011677	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
321314011678	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
321314011679	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
321314011680	glutaminase active site [active]
321314011681	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
321314011682	dimer interface [polypeptide binding]; other site
321314011683	active site
321314011684	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
321314011685	dimer interface [polypeptide binding]; other site
321314011686	active site
321314011687	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
321314011688	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
321314011689	Substrate binding site; other site
321314011690	Mg++ binding site; other site
321314011691	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
321314011692	active site
321314011693	substrate binding site [chemical binding]; other site
321314011694	CoA binding site [chemical binding]; other site
321314011695	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
321314011696	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
321314011697	gamma subunit interface [polypeptide binding]; other site
321314011698	epsilon subunit interface [polypeptide binding]; other site
321314011699	LBP interface [polypeptide binding]; other site
321314011700	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
321314011701	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
321314011702	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
321314011703	alpha subunit interaction interface [polypeptide binding]; other site
321314011704	Walker A motif; other site
321314011705	ATP binding site [chemical binding]; other site
321314011706	Walker B motif; other site
321314011707	inhibitor binding site; inhibition site
321314011708	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
321314011709	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
321314011710	core domain interface [polypeptide binding]; other site
321314011711	delta subunit interface [polypeptide binding]; other site
321314011712	epsilon subunit interface [polypeptide binding]; other site
321314011713	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
321314011714	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
321314011715	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
321314011716	beta subunit interaction interface [polypeptide binding]; other site
321314011717	Walker A motif; other site
321314011718	ATP binding site [chemical binding]; other site
321314011719	Walker B motif; other site
321314011720	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
321314011721	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
321314011722	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
321314011723	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
321314011724	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
321314011725	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
321314011726	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
321314011727	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
321314011728	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
321314011729	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
321314011730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314011731	S-adenosylmethionine binding site [chemical binding]; other site
321314011732	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
321314011733	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
321314011734	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
321314011735	FMN-binding protein MioC; Provisional; Region: PRK09004
321314011736	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
321314011737	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314011738	putative DNA binding site [nucleotide binding]; other site
321314011739	putative Zn2+ binding site [ion binding]; other site
321314011740	AsnC family; Region: AsnC_trans_reg; pfam01037
321314011741	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
321314011742	dimer interface [polypeptide binding]; other site
321314011743	active site
321314011744	hypothetical protein; Provisional; Region: yieM; PRK10997
321314011745	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
321314011746	metal ion-dependent adhesion site (MIDAS); other site
321314011747	regulatory ATPase RavA; Provisional; Region: PRK13531
321314011748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314011749	Walker A motif; other site
321314011750	ATP binding site [chemical binding]; other site
321314011751	Walker B motif; other site
321314011752	arginine finger; other site
321314011753	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
321314011754	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
321314011755	potassium uptake protein; Region: kup; TIGR00794
321314011756	D-ribose pyranase; Provisional; Region: PRK11797
321314011757	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
321314011758	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
321314011759	Walker A/P-loop; other site
321314011760	ATP binding site [chemical binding]; other site
321314011761	Q-loop/lid; other site
321314011762	ABC transporter signature motif; other site
321314011763	Walker B; other site
321314011764	D-loop; other site
321314011765	H-loop/switch region; other site
321314011766	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
321314011767	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
321314011768	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
321314011769	TM-ABC transporter signature motif; other site
321314011770	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
321314011771	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
321314011772	ligand binding site [chemical binding]; other site
321314011773	dimerization interface [polypeptide binding]; other site
321314011774	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314011775	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
321314011776	substrate binding site [chemical binding]; other site
321314011777	dimer interface [polypeptide binding]; other site
321314011778	ATP binding site [chemical binding]; other site
321314011779	transcriptional repressor RbsR; Provisional; Region: PRK10423
321314011780	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314011781	DNA binding site [nucleotide binding]
321314011782	domain linker motif; other site
321314011783	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
321314011784	dimerization interface [polypeptide binding]; other site
321314011785	ligand binding site [chemical binding]; other site
321314011786	putative transporter; Provisional; Region: PRK10504
321314011787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011788	putative substrate translocation pore; other site
321314011789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314011790	Transcriptional regulators [Transcription]; Region: FadR; COG2186
321314011791	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314011792	DNA-binding site [nucleotide binding]; DNA binding site
321314011793	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
321314011794	transcriptional regulator HdfR; Provisional; Region: PRK03601
321314011795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314011796	LysR substrate binding domain; Region: LysR_substrate; pfam03466
321314011797	dimerization interface [polypeptide binding]; other site
321314011798	hypothetical protein; Provisional; Region: PRK11027
321314011799	putative ATP-dependent protease; Provisional; Region: PRK09862
321314011800	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
321314011801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314011802	Walker A motif; other site
321314011803	ATP binding site [chemical binding]; other site
321314011804	Walker B motif; other site
321314011805	arginine finger; other site
321314011806	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
321314011807	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
321314011808	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
321314011809	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
321314011810	homodimer interface [polypeptide binding]; other site
321314011811	substrate-cofactor binding pocket; other site
321314011812	catalytic residue [active]
321314011813	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
321314011814	threonine dehydratase; Reviewed; Region: PRK09224
321314011815	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
321314011816	tetramer interface [polypeptide binding]; other site
321314011817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314011818	catalytic residue [active]
321314011819	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
321314011820	putative Ile/Val binding site [chemical binding]; other site
321314011821	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
321314011822	putative Ile/Val binding site [chemical binding]; other site
321314011823	Phage-related protein [Function unknown]; Region: COG4679
321314011824	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
321314011825	non-specific DNA binding site [nucleotide binding]; other site
321314011826	salt bridge; other site
321314011827	sequence-specific DNA binding site [nucleotide binding]; other site
321314011828	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314011829	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
321314011830	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
321314011831	putative dimerization interface [polypeptide binding]; other site
321314011832	ketol-acid reductoisomerase; Validated; Region: PRK05225
321314011833	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
321314011834	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
321314011835	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
321314011836	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
321314011837	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
321314011838	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
321314011839	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
321314011840	Part of AAA domain; Region: AAA_19; pfam13245
321314011841	Family description; Region: UvrD_C_2; pfam13538
321314011842	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
321314011843	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
321314011844	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
321314011845	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
321314011846	ATP binding site [chemical binding]; other site
321314011847	Mg++ binding site [ion binding]; other site
321314011848	motif III; other site
321314011849	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314011850	nucleotide binding region [chemical binding]; other site
321314011851	ATP-binding site [chemical binding]; other site
321314011852	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
321314011853	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
321314011854	catalytic residues [active]
321314011855	transcription termination factor Rho; Provisional; Region: rho; PRK09376
321314011856	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
321314011857	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
321314011858	RNA binding site [nucleotide binding]; other site
321314011859	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
321314011860	multimer interface [polypeptide binding]; other site
321314011861	Walker A motif; other site
321314011862	ATP binding site [chemical binding]; other site
321314011863	Walker B motif; other site
321314011864	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
321314011865	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
321314011866	Mg++ binding site [ion binding]; other site
321314011867	putative catalytic motif [active]
321314011868	substrate binding site [chemical binding]; other site
321314011869	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
321314011870	Chain length determinant protein; Region: Wzz; pfam02706
321314011871	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
321314011872	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
321314011873	homodimer interface [polypeptide binding]; other site
321314011874	active site
321314011875	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
321314011876	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
321314011877	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
321314011878	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
321314011879	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
321314011880	NAD binding site [chemical binding]; other site
321314011881	substrate binding site [chemical binding]; other site
321314011882	homodimer interface [polypeptide binding]; other site
321314011883	active site
321314011884	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
321314011885	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
321314011886	substrate binding site; other site
321314011887	tetramer interface; other site
321314011888	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
321314011889	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
321314011890	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
321314011891	inhibitor-cofactor binding pocket; inhibition site
321314011892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314011893	catalytic residue [active]
321314011894	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
321314011895	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
321314011896	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
321314011897	putative common antigen polymerase; Provisional; Region: PRK02975
321314011898	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
321314011899	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
321314011900	putative transport protein YifK; Provisional; Region: PRK10746
321314011901	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
321314011902	HemY protein N-terminus; Region: HemY_N; pfam07219
321314011903	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
321314011904	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
321314011905	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
321314011906	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
321314011907	active site
321314011908	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
321314011909	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
321314011910	domain interfaces; other site
321314011911	active site
321314011912	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
321314011913	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
321314011914	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
321314011915	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
321314011916	putative iron binding site [ion binding]; other site
321314011917	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
321314011918	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
321314011919	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
321314011920	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
321314011921	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
321314011922	hypothetical protein; Provisional; Region: PRK10963
321314011923	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
321314011924	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
321314011925	active site
321314011926	Int/Topo IB signature motif; other site
321314011927	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
321314011928	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314011929	motif II; other site
321314011930	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
321314011931	Part of AAA domain; Region: AAA_19; pfam13245
321314011932	Family description; Region: UvrD_C_2; pfam13538
321314011933	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
321314011934	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
321314011935	Cl binding site [ion binding]; other site
321314011936	oligomer interface [polypeptide binding]; other site
321314011937	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
321314011938	EamA-like transporter family; Region: EamA; cl17759
321314011939	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
321314011940	CoenzymeA binding site [chemical binding]; other site
321314011941	subunit interaction site [polypeptide binding]; other site
321314011942	PHB binding site; other site
321314011943	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
321314011944	dimerization interface [polypeptide binding]; other site
321314011945	substrate binding site [chemical binding]; other site
321314011946	active site
321314011947	calcium binding site [ion binding]; other site
321314011948	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
321314011949	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314011950	ATP binding site [chemical binding]; other site
321314011951	putative Mg++ binding site [ion binding]; other site
321314011952	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
321314011953	nucleotide binding region [chemical binding]; other site
321314011954	ATP-binding site [chemical binding]; other site
321314011955	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
321314011956	Helicase and RNase D C-terminal; Region: HRDC; smart00341
321314011957	threonine efflux system; Provisional; Region: PRK10229
321314011958	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
321314011959	lysophospholipase L2; Provisional; Region: PRK10749
321314011960	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
321314011961	putative hydrolase; Provisional; Region: PRK10976
321314011962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314011963	active site
321314011964	motif I; other site
321314011965	motif II; other site
321314011966	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314011967	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
321314011968	EamA-like transporter family; Region: EamA; pfam00892
321314011969	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
321314011970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314011971	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
321314011972	putative dimerization interface [polypeptide binding]; other site
321314011973	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
321314011974	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
321314011975	THF binding site; other site
321314011976	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
321314011977	substrate binding site [chemical binding]; other site
321314011978	THF binding site; other site
321314011979	zinc-binding site [ion binding]; other site
321314011980	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
321314011981	uridine phosphorylase; Provisional; Region: PRK11178
321314011982	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
321314011983	DNA recombination protein RmuC; Provisional; Region: PRK10361
321314011984	RmuC family; Region: RmuC; pfam02646
321314011985	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
321314011986	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314011987	S-adenosylmethionine binding site [chemical binding]; other site
321314011988	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
321314011989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
321314011990	SCP-2 sterol transfer family; Region: SCP2; pfam02036
321314011991	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
321314011992	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
321314011993	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
321314011994	sec-independent translocase; Provisional; Region: PRK01770
321314011995	sec-independent translocase; Provisional; Region: tatB; PRK00404
321314011996	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
321314011997	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
321314011998	active site
321314011999	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
321314012000	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
321314012001	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
321314012002	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
321314012003	FMN reductase; Validated; Region: fre; PRK08051
321314012004	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
321314012005	FAD binding pocket [chemical binding]; other site
321314012006	FAD binding motif [chemical binding]; other site
321314012007	phosphate binding motif [ion binding]; other site
321314012008	beta-alpha-beta structure motif; other site
321314012009	NAD binding pocket [chemical binding]; other site
321314012010	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
321314012011	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
321314012012	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
321314012013	dimer interface [polypeptide binding]; other site
321314012014	active site
321314012015	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
321314012016	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
321314012017	substrate binding site [chemical binding]; other site
321314012018	oxyanion hole (OAH) forming residues; other site
321314012019	trimer interface [polypeptide binding]; other site
321314012020	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
321314012021	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
321314012022	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
321314012023	proline dipeptidase; Provisional; Region: PRK13607
321314012024	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
321314012025	active site
321314012026	hypothetical protein; Provisional; Region: PRK11568
321314012027	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
321314012028	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
321314012029	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
321314012030	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
321314012031	Walker A motif; other site
321314012032	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
321314012033	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
321314012034	GTP binding site; other site
321314012035	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
321314012036	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
321314012037	serine/threonine protein kinase; Provisional; Region: PRK11768
321314012038	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
321314012039	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
321314012040	catalytic residues [active]
321314012041	hinge region; other site
321314012042	alpha helical domain; other site
321314012043	DNA polymerase I; Provisional; Region: PRK05755
321314012044	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
321314012045	active site
321314012046	metal binding site 1 [ion binding]; metal-binding site
321314012047	putative 5' ssDNA interaction site; other site
321314012048	metal binding site 3; metal-binding site
321314012049	metal binding site 2 [ion binding]; metal-binding site
321314012050	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
321314012051	putative DNA binding site [nucleotide binding]; other site
321314012052	putative metal binding site [ion binding]; other site
321314012053	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
321314012054	active site
321314012055	catalytic site [active]
321314012056	substrate binding site [chemical binding]; other site
321314012057	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
321314012058	active site
321314012059	DNA binding site [nucleotide binding]
321314012060	catalytic site [active]
321314012061	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
321314012062	G1 box; other site
321314012063	GTP/Mg2+ binding site [chemical binding]; other site
321314012064	Switch I region; other site
321314012065	G2 box; other site
321314012066	G3 box; other site
321314012067	Switch II region; other site
321314012068	G4 box; other site
321314012069	G5 box; other site
321314012070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
321314012071	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
321314012072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314012073	FeS/SAM binding site; other site
321314012074	HemN C-terminal domain; Region: HemN_C; pfam06969
321314012075	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
321314012076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314012077	active site
321314012078	phosphorylation site [posttranslational modification]
321314012079	intermolecular recognition site; other site
321314012080	dimerization interface [polypeptide binding]; other site
321314012081	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314012082	Walker A motif; other site
321314012083	ATP binding site [chemical binding]; other site
321314012084	Walker B motif; other site
321314012085	arginine finger; other site
321314012086	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
321314012087	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
321314012088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
321314012089	putative active site [active]
321314012090	heme pocket [chemical binding]; other site
321314012091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314012092	dimer interface [polypeptide binding]; other site
321314012093	phosphorylation site [posttranslational modification]
321314012094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314012095	ATP binding site [chemical binding]; other site
321314012096	Mg2+ binding site [ion binding]; other site
321314012097	G-X-G motif; other site
321314012098	glutamine synthetase; Provisional; Region: glnA; PRK09469
321314012099	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
321314012100	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
321314012101	GTP-binding protein; Provisional; Region: PRK10218
321314012102	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
321314012103	G1 box; other site
321314012104	putative GEF interaction site [polypeptide binding]; other site
321314012105	GTP/Mg2+ binding site [chemical binding]; other site
321314012106	Switch I region; other site
321314012107	G2 box; other site
321314012108	G3 box; other site
321314012109	Switch II region; other site
321314012110	G4 box; other site
321314012111	G5 box; other site
321314012112	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
321314012113	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
321314012114	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314012115	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
321314012116	active site
321314012117	motif I; other site
321314012118	motif II; other site
321314012119	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
321314012120	coproporphyrinogen III oxidase; Validated; Region: PRK08208
321314012121	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314012122	FeS/SAM binding site; other site
321314012123	HemN C-terminal domain; Region: HemN_C; pfam06969
321314012124	Sulfatase; Region: Sulfatase; cl17466
321314012125	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
321314012126	outer membrane porin L; Provisional; Region: ompL; PRK09980
321314012127	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
321314012128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314012129	putative substrate translocation pore; other site
321314012130	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
321314012131	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
321314012132	alpha-glucosidase; Provisional; Region: PRK10426
321314012133	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
321314012134	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
321314012135	putative active site [active]
321314012136	putative catalytic site [active]
321314012137	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
321314012138	active site
321314012139	catalytic residues [active]
321314012140	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
321314012141	catalytic residue [active]
321314012142	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
321314012143	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
321314012144	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314012145	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
321314012146	substrate binding site [chemical binding]; other site
321314012147	ATP binding site [chemical binding]; other site
321314012148	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
321314012149	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
321314012150	putative DNA binding site [nucleotide binding]; other site
321314012151	putative Zn2+ binding site [ion binding]; other site
321314012152	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314012153	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
321314012154	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314012155	motif II; other site
321314012156	hypothetical protein; Reviewed; Region: PRK01637
321314012157	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
321314012158	putative active site [active]
321314012159	dimerization interface [polypeptide binding]; other site
321314012160	putative tRNAtyr binding site [nucleotide binding]; other site
321314012161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314012162	Coenzyme A binding pocket [chemical binding]; other site
321314012163	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
321314012164	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
321314012165	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
321314012166	substrate binding pocket [chemical binding]; other site
321314012167	Predicted transcriptional regulator [Transcription]; Region: COG2944
321314012168	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314012169	non-specific DNA binding site [nucleotide binding]; other site
321314012170	salt bridge; other site
321314012171	sequence-specific DNA binding site [nucleotide binding]; other site
321314012172	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
321314012173	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
321314012174	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
321314012175	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
321314012176	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
321314012177	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
321314012178	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
321314012179	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
321314012180	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
321314012181	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
321314012182	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
321314012183	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
321314012184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314012185	non-specific DNA binding site [nucleotide binding]; other site
321314012186	salt bridge; other site
321314012187	sequence-specific DNA binding site [nucleotide binding]; other site
321314012188	Cupin domain; Region: Cupin_2; cl17218
321314012189	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
321314012190	lactaldehyde reductase; Region: lactal_redase; TIGR02638
321314012191	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
321314012192	dimer interface [polypeptide binding]; other site
321314012193	active site
321314012194	metal binding site [ion binding]; metal-binding site
321314012195	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
321314012196	intersubunit interface [polypeptide binding]; other site
321314012197	active site
321314012198	Zn2+ binding site [ion binding]; other site
321314012199	L-rhamnose isomerase; Provisional; Region: PRK01076
321314012200	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
321314012201	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
321314012202	N- and C-terminal domain interface [polypeptide binding]; other site
321314012203	active site
321314012204	putative catalytic site [active]
321314012205	metal binding site [ion binding]; metal-binding site
321314012206	ATP binding site [chemical binding]; other site
321314012207	rhamnulokinase; Provisional; Region: rhaB; PRK10640
321314012208	carbohydrate binding site [chemical binding]; other site
321314012209	transcriptional activator RhaS; Provisional; Region: PRK13503
321314012210	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
321314012211	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012213	transcriptional activator RhaR; Provisional; Region: PRK13502
321314012214	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
321314012215	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012216	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
321314012217	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
321314012218	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
321314012219	DctM-like transporters; Region: DctM; pfam06808
321314012220	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
321314012221	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
321314012222	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
321314012223	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
321314012224	superoxide dismutase; Provisional; Region: PRK10925
321314012225	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
321314012226	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
321314012227	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
321314012228	MOSC domain; Region: MOSC; pfam03473
321314012229	3-alpha domain; Region: 3-alpha; pfam03475
321314012230	SnoaL-like domain; Region: SnoaL_2; pfam12680
321314012231	two-component sensor protein; Provisional; Region: cpxA; PRK09470
321314012232	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314012233	dimerization interface [polypeptide binding]; other site
321314012234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314012235	dimer interface [polypeptide binding]; other site
321314012236	phosphorylation site [posttranslational modification]
321314012237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314012238	ATP binding site [chemical binding]; other site
321314012239	Mg2+ binding site [ion binding]; other site
321314012240	G-X-G motif; other site
321314012241	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
321314012242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314012243	active site
321314012244	intermolecular recognition site; other site
321314012245	dimerization interface [polypeptide binding]; other site
321314012246	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314012247	DNA binding site [nucleotide binding]
321314012248	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
321314012249	dimer interface [polypeptide binding]; other site
321314012250	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
321314012251	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
321314012252	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
321314012253	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
321314012254	active site
321314012255	ADP/pyrophosphate binding site [chemical binding]; other site
321314012256	dimerization interface [polypeptide binding]; other site
321314012257	allosteric effector site; other site
321314012258	fructose-1,6-bisphosphate binding site; other site
321314012259	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
321314012260	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314012261	substrate binding pocket [chemical binding]; other site
321314012262	membrane-bound complex binding site; other site
321314012263	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
321314012264	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
321314012265	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
321314012266	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
321314012267	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
321314012268	putative substrate binding site [chemical binding]; other site
321314012269	putative ATP binding site [chemical binding]; other site
321314012270	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
321314012271	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
321314012272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314012273	DNA-binding site [nucleotide binding]; DNA binding site
321314012274	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
321314012275	UTRA domain; Region: UTRA; pfam07702
321314012276	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
321314012277	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
321314012278	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
321314012279	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
321314012280	putative N- and C-terminal domain interface [polypeptide binding]; other site
321314012281	putative active site [active]
321314012282	putative MgATP binding site [chemical binding]; other site
321314012283	catalytic site [active]
321314012284	metal binding site [ion binding]; metal-binding site
321314012285	putative carbohydrate binding site [chemical binding]; other site
321314012286	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
321314012287	transcriptional regulator LsrR; Provisional; Region: PRK15418
321314012288	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
321314012289	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
321314012290	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
321314012291	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
321314012292	TM-ABC transporter signature motif; other site
321314012293	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
321314012294	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
321314012295	TM-ABC transporter signature motif; other site
321314012296	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
321314012297	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
321314012298	ligand binding site [chemical binding]; other site
321314012299	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
321314012300	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
321314012301	putative active site; other site
321314012302	catalytic residue [active]
321314012303	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
321314012304	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
321314012305	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
321314012306	substrate binding site [chemical binding]; other site
321314012307	hexamer interface [polypeptide binding]; other site
321314012308	metal binding site [ion binding]; metal-binding site
321314012309	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
321314012310	triosephosphate isomerase; Provisional; Region: PRK14567
321314012311	substrate binding site [chemical binding]; other site
321314012312	dimer interface [polypeptide binding]; other site
321314012313	catalytic triad [active]
321314012314	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
321314012315	Predicted membrane protein [Function unknown]; Region: COG3152
321314012316	ferredoxin-NADP reductase; Provisional; Region: PRK10926
321314012317	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
321314012318	FAD binding pocket [chemical binding]; other site
321314012319	FAD binding motif [chemical binding]; other site
321314012320	phosphate binding motif [ion binding]; other site
321314012321	beta-alpha-beta structure motif; other site
321314012322	NAD binding pocket [chemical binding]; other site
321314012323	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
321314012324	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
321314012325	putative active site [active]
321314012326	glycerol kinase; Provisional; Region: glpK; PRK00047
321314012327	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
321314012328	N- and C-terminal domain interface [polypeptide binding]; other site
321314012329	active site
321314012330	MgATP binding site [chemical binding]; other site
321314012331	catalytic site [active]
321314012332	metal binding site [ion binding]; metal-binding site
321314012333	glycerol binding site [chemical binding]; other site
321314012334	homotetramer interface [polypeptide binding]; other site
321314012335	homodimer interface [polypeptide binding]; other site
321314012336	FBP binding site [chemical binding]; other site
321314012337	protein IIAGlc interface [polypeptide binding]; other site
321314012338	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
321314012339	amphipathic channel; other site
321314012340	Asn-Pro-Ala signature motifs; other site
321314012341	septal ring assembly protein ZapB; Provisional; Region: PRK15422
321314012342	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
321314012343	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
321314012344	UbiA prenyltransferase family; Region: UbiA; pfam01040
321314012345	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
321314012346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314012347	Walker A motif; other site
321314012348	ATP binding site [chemical binding]; other site
321314012349	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
321314012350	Walker B motif; other site
321314012351	arginine finger; other site
321314012352	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
321314012353	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
321314012354	active site
321314012355	HslU subunit interaction site [polypeptide binding]; other site
321314012356	essential cell division protein FtsN; Provisional; Region: PRK10927
321314012357	cell division protein FtsN; Provisional; Region: PRK12757
321314012358	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314012359	DNA binding site [nucleotide binding]
321314012360	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
321314012361	domain linker motif; other site
321314012362	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
321314012363	dimerization interface [polypeptide binding]; other site
321314012364	ligand binding site [chemical binding]; other site
321314012365	primosome assembly protein PriA; Validated; Region: PRK05580
321314012366	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
321314012367	ATP binding site [chemical binding]; other site
321314012368	putative Mg++ binding site [ion binding]; other site
321314012369	helicase superfamily c-terminal domain; Region: HELICc; smart00490
321314012370	ATP-binding site [chemical binding]; other site
321314012371	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
321314012372	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314012373	Integrase core domain; Region: rve; pfam00665
321314012374	Integrase core domain; Region: rve_3; pfam13683
321314012375	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
321314012376	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
321314012377	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
321314012378	dimerization interface [polypeptide binding]; other site
321314012379	DNA binding site [nucleotide binding]
321314012380	corepressor binding sites; other site
321314012381	cystathionine gamma-synthase; Provisional; Region: PRK08045
321314012382	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
321314012383	homodimer interface [polypeptide binding]; other site
321314012384	substrate-cofactor binding pocket; other site
321314012385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314012386	catalytic residue [active]
321314012387	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
321314012388	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
321314012389	putative catalytic residues [active]
321314012390	putative nucleotide binding site [chemical binding]; other site
321314012391	putative aspartate binding site [chemical binding]; other site
321314012392	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
321314012393	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
321314012394	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
321314012395	mechanosensitive channel MscS; Provisional; Region: PRK10334
321314012396	Conserved TM helix; Region: TM_helix; pfam05552
321314012397	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314012398	aspartate aminotransferase; Provisional; Region: PRK06836
321314012399	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
321314012400	FAD binding site [chemical binding]; other site
321314012401	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
321314012402	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
321314012403	heme binding site [chemical binding]; other site
321314012404	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
321314012405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
321314012406	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
321314012407	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
321314012408	dimer interface [polypeptide binding]; other site
321314012409	active site
321314012410	metal binding site [ion binding]; metal-binding site
321314012411	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
321314012412	active site
321314012413	intersubunit interactions; other site
321314012414	catalytic residue [active]
321314012415	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
321314012416	dimerization domain swap beta strand [polypeptide binding]; other site
321314012417	regulatory protein interface [polypeptide binding]; other site
321314012418	active site
321314012419	regulatory phosphorylation site [posttranslational modification]; other site
321314012420	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
321314012421	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
321314012422	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
321314012423	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
321314012424	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314012425	active site
321314012426	phosphorylation site [posttranslational modification]
321314012427	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
321314012428	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
321314012429	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
321314012430	active site
321314012431	P-loop; other site
321314012432	phosphorylation site [posttranslational modification]
321314012433	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314012434	FeS/SAM binding site; other site
321314012435	pyruvate formate lyase II activase; Provisional; Region: PRK10076
321314012436	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
321314012437	active site
321314012438	P-loop; other site
321314012439	phosphorylation site [posttranslational modification]
321314012440	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
321314012441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012442	hypothetical protein; Provisional; Region: PRK10649
321314012443	Sulfatase; Region: Sulfatase; pfam00884
321314012444	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
321314012445	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
321314012446	acetylornithine deacetylase; Provisional; Region: PRK05111
321314012447	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
321314012448	metal binding site [ion binding]; metal-binding site
321314012449	putative dimer interface [polypeptide binding]; other site
321314012450	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
321314012451	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
321314012452	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
321314012453	nucleotide binding site [chemical binding]; other site
321314012454	N-acetyl-L-glutamate binding site [chemical binding]; other site
321314012455	argininosuccinate lyase; Provisional; Region: PRK04833
321314012456	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
321314012457	active sites [active]
321314012458	tetramer interface [polypeptide binding]; other site
321314012459	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
321314012460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314012461	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
321314012462	dimerization interface [polypeptide binding]; other site
321314012463	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
321314012464	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
321314012465	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
321314012466	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
321314012467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314012468	hypothetical protein; Provisional; Region: PRK11056
321314012469	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
321314012470	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
321314012471	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314012472	S-adenosylmethionine binding site [chemical binding]; other site
321314012473	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
321314012474	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
321314012475	N-terminal plug; other site
321314012476	ligand-binding site [chemical binding]; other site
321314012477	glutamate racemase; Provisional; Region: PRK00865
321314012478	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
321314012479	FAD binding domain; Region: FAD_binding_4; pfam01565
321314012480	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
321314012481	Biotin operon repressor [Transcription]; Region: BirA; COG1654
321314012482	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
321314012483	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
321314012484	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
321314012485	pantothenate kinase; Provisional; Region: PRK05439
321314012486	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
321314012487	ATP-binding site [chemical binding]; other site
321314012488	CoA-binding site [chemical binding]; other site
321314012489	Mg2+-binding site [ion binding]; other site
321314012490	elongation factor Tu; Reviewed; Region: PRK00049
321314012491	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
321314012492	G1 box; other site
321314012493	GEF interaction site [polypeptide binding]; other site
321314012494	GTP/Mg2+ binding site [chemical binding]; other site
321314012495	Switch I region; other site
321314012496	G2 box; other site
321314012497	G3 box; other site
321314012498	Switch II region; other site
321314012499	G4 box; other site
321314012500	G5 box; other site
321314012501	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
321314012502	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
321314012503	Antibiotic Binding Site [chemical binding]; other site
321314012504	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
321314012505	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
321314012506	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
321314012507	putative homodimer interface [polypeptide binding]; other site
321314012508	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
321314012509	heterodimer interface [polypeptide binding]; other site
321314012510	homodimer interface [polypeptide binding]; other site
321314012511	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
321314012512	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
321314012513	23S rRNA interface [nucleotide binding]; other site
321314012514	L7/L12 interface [polypeptide binding]; other site
321314012515	putative thiostrepton binding site; other site
321314012516	L25 interface [polypeptide binding]; other site
321314012517	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
321314012518	mRNA/rRNA interface [nucleotide binding]; other site
321314012519	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
321314012520	23S rRNA interface [nucleotide binding]; other site
321314012521	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
321314012522	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
321314012523	core dimer interface [polypeptide binding]; other site
321314012524	peripheral dimer interface [polypeptide binding]; other site
321314012525	L10 interface [polypeptide binding]; other site
321314012526	L11 interface [polypeptide binding]; other site
321314012527	putative EF-Tu interaction site [polypeptide binding]; other site
321314012528	putative EF-G interaction site [polypeptide binding]; other site
321314012529	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
321314012530	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
321314012531	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
321314012532	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
321314012533	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
321314012534	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
321314012535	RPB3 interaction site [polypeptide binding]; other site
321314012536	RPB1 interaction site [polypeptide binding]; other site
321314012537	RPB11 interaction site [polypeptide binding]; other site
321314012538	RPB10 interaction site [polypeptide binding]; other site
321314012539	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
321314012540	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
321314012541	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
321314012542	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
321314012543	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
321314012544	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
321314012545	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
321314012546	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
321314012547	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
321314012548	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
321314012549	DNA binding site [nucleotide binding]
321314012550	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
321314012551	type III secretion system protein; Provisional; Region: PRK15384
321314012552	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
321314012553	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
321314012554	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314012555	FeS/SAM binding site; other site
321314012556	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
321314012557	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
321314012558	ThiS interaction site; other site
321314012559	putative active site [active]
321314012560	tetramer interface [polypeptide binding]; other site
321314012561	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
321314012562	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
321314012563	ATP binding site [chemical binding]; other site
321314012564	substrate interface [chemical binding]; other site
321314012565	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
321314012566	thiamine phosphate binding site [chemical binding]; other site
321314012567	active site
321314012568	pyrophosphate binding site [ion binding]; other site
321314012569	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
321314012570	ThiC-associated domain; Region: ThiC-associated; pfam13667
321314012571	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
321314012572	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
321314012573	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
321314012574	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
321314012575	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
321314012576	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
321314012577	putative NADH binding site [chemical binding]; other site
321314012578	putative active site [active]
321314012579	nudix motif; other site
321314012580	putative metal binding site [ion binding]; other site
321314012581	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
321314012582	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
321314012583	substrate binding site [chemical binding]; other site
321314012584	active site
321314012585	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
321314012586	Active_site [active]
321314012587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
321314012588	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
321314012589	IHF dimer interface [polypeptide binding]; other site
321314012590	IHF - DNA interface [nucleotide binding]; other site
321314012591	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
321314012592	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
321314012593	dimer interface [polypeptide binding]; other site
321314012594	sensor protein ZraS; Provisional; Region: PRK10364
321314012595	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314012596	dimer interface [polypeptide binding]; other site
321314012597	phosphorylation site [posttranslational modification]
321314012598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314012599	ATP binding site [chemical binding]; other site
321314012600	Mg2+ binding site [ion binding]; other site
321314012601	G-X-G motif; other site
321314012602	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
321314012603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314012604	active site
321314012605	phosphorylation site [posttranslational modification]
321314012606	intermolecular recognition site; other site
321314012607	dimerization interface [polypeptide binding]; other site
321314012608	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314012609	Walker A motif; other site
321314012610	ATP binding site [chemical binding]; other site
321314012611	Walker B motif; other site
321314012612	arginine finger; other site
321314012613	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
321314012614	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
321314012615	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
321314012616	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
321314012617	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
321314012618	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
321314012619	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314012620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
321314012621	Coenzyme A binding pocket [chemical binding]; other site
321314012622	homoserine O-succinyltransferase; Provisional; Region: PRK05368
321314012623	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
321314012624	proposed active site lysine [active]
321314012625	conserved cys residue [active]
321314012626	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
321314012627	malate synthase A; Region: malate_syn_A; TIGR01344
321314012628	active site
321314012629	isocitrate lyase; Provisional; Region: PRK15063
321314012630	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
321314012631	tetramer interface [polypeptide binding]; other site
321314012632	active site
321314012633	Mg2+/Mn2+ binding site [ion binding]; other site
321314012634	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
321314012635	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
321314012636	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
321314012637	transcriptional repressor IclR; Provisional; Region: PRK11569
321314012638	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
321314012639	Bacterial transcriptional regulator; Region: IclR; pfam01614
321314012640	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
321314012641	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
321314012642	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
321314012643	substrate binding pocket [chemical binding]; other site
321314012644	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
321314012645	B12 binding site [chemical binding]; other site
321314012646	cobalt ligand [ion binding]; other site
321314012647	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
321314012648	similar to Tn10
321314012649	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
321314012650	active site pocket [active]
321314012651	oxyanion hole [active]
321314012652	catalytic triad [active]
321314012653	active site nucleophile [active]
321314012654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
321314012655	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
321314012656	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
321314012657	RNA binding surface [nucleotide binding]; other site
321314012658	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
321314012659	probable active site [active]
321314012660	hypothetical protein; Provisional; Region: PRK10515
321314012661	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
321314012662	Sodium Bile acid symporter family; Region: SBF; pfam01758
321314012663	Domain of unknown function (DUF4376); Region: DUF4376; pfam14301
321314012664	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
321314012665	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
321314012666	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
321314012667	Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948
321314012668	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
321314012669	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
321314012670	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
321314012671	Ligand binding site; other site
321314012672	Putative Catalytic site; other site
321314012673	DXD motif; other site
321314012674	Predicted membrane protein [Function unknown]; Region: COG2246
321314012675	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
321314012676	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
321314012677	Phage protein D [General function prediction only]; Region: COG3500
321314012678	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
321314012679	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
321314012680	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
321314012681	Phage tail tube protein FII [General function prediction only]; Region: COG3498
321314012682	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
321314012683	Gp37 protein; Region: Gp37; pfam09646
321314012684	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
321314012685	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314012686	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314012687	catalytic residue [active]
321314012688	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
321314012689	Mor transcription activator family; Region: Mor; pfam08765
321314012690	aspartate kinase III; Validated; Region: PRK09084
321314012691	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
321314012692	nucleotide binding site [chemical binding]; other site
321314012693	substrate binding site [chemical binding]; other site
321314012694	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
321314012695	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
321314012696	dimer interface [polypeptide binding]; other site
321314012697	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
321314012698	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
321314012699	active site
321314012700	dimer interface [polypeptide binding]; other site
321314012701	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
321314012702	dimer interface [polypeptide binding]; other site
321314012703	active site
321314012704	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
321314012705	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
321314012706	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
321314012707	Predicted membrane protein [Function unknown]; Region: COG3223
321314012708	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
321314012709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314012710	dimer interface [polypeptide binding]; other site
321314012711	conserved gate region; other site
321314012712	putative PBP binding loops; other site
321314012713	ABC-ATPase subunit interface; other site
321314012714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
321314012715	dimer interface [polypeptide binding]; other site
321314012716	conserved gate region; other site
321314012717	putative PBP binding loops; other site
321314012718	ABC-ATPase subunit interface; other site
321314012719	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
321314012720	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
321314012721	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
321314012722	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
321314012723	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
321314012724	Walker A/P-loop; other site
321314012725	ATP binding site [chemical binding]; other site
321314012726	Q-loop/lid; other site
321314012727	ABC transporter signature motif; other site
321314012728	Walker B; other site
321314012729	D-loop; other site
321314012730	H-loop/switch region; other site
321314012731	TOBE domain; Region: TOBE_2; pfam08402
321314012732	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
321314012733	trimer interface; other site
321314012734	sugar binding site [chemical binding]; other site
321314012735	maltose regulon periplasmic protein; Provisional; Region: PRK10564
321314012736	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
321314012737	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
321314012738	UbiA prenyltransferase family; Region: UbiA; pfam01040
321314012739	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
321314012740	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
321314012741	putative acyl-acceptor binding pocket; other site
321314012742	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
321314012743	LexA repressor; Validated; Region: PRK00215
321314012744	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
321314012745	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
321314012746	Catalytic site [active]
321314012747	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
321314012748	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
321314012749	hypothetical protein; Provisional; Region: PRK10428
321314012750	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
321314012751	metal binding site 2 [ion binding]; metal-binding site
321314012752	putative DNA binding helix; other site
321314012753	metal binding site 1 [ion binding]; metal-binding site
321314012754	dimer interface [polypeptide binding]; other site
321314012755	structural Zn2+ binding site [ion binding]; other site
321314012756	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
321314012757	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
321314012758	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
321314012759	FMN binding site [chemical binding]; other site
321314012760	active site
321314012761	catalytic residues [active]
321314012762	substrate binding site [chemical binding]; other site
321314012763	phage shock protein G; Reviewed; Region: pspG; PRK09459
321314012764	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
321314012765	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
321314012766	NADP binding site [chemical binding]; other site
321314012767	dimer interface [polypeptide binding]; other site
321314012768	replicative DNA helicase; Provisional; Region: PRK08006
321314012769	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
321314012770	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
321314012771	Walker A motif; other site
321314012772	ATP binding site [chemical binding]; other site
321314012773	Walker B motif; other site
321314012774	DNA binding loops [nucleotide binding]
321314012775	alanine racemase; Reviewed; Region: alr; PRK00053
321314012776	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
321314012777	active site
321314012778	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
321314012779	substrate binding site [chemical binding]; other site
321314012780	catalytic residues [active]
321314012781	dimer interface [polypeptide binding]; other site
321314012782	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
321314012783	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
321314012784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314012785	homodimer interface [polypeptide binding]; other site
321314012786	catalytic residue [active]
321314012787	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
321314012788	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314012789	active site
321314012790	motif I; other site
321314012791	motif II; other site
321314012792	Uncharacterized conserved protein [Function unknown]; Region: COG0432
321314012793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
321314012794	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
321314012795	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
321314012796	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
321314012797	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
321314012798	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
321314012799	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
321314012800	dimer interface [polypeptide binding]; other site
321314012801	ssDNA binding site [nucleotide binding]; other site
321314012802	tetramer (dimer of dimers) interface [polypeptide binding]; other site
321314012803	hypothetical protein; Validated; Region: PRK09039
321314012804	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
321314012805	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
321314012806	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
321314012807	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
321314012808	HlyD family secretion protein; Region: HlyD_3; pfam13437
321314012809	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012810	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012811	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012812	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012813	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012814	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
321314012815	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012816	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012817	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
321314012818	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012819	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012820	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012821	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012822	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
321314012823	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012824	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012825	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012826	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012827	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
321314012828	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012829	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012830	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
321314012831	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012832	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012833	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012834	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012835	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
321314012836	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012837	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012838	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012839	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012840	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012841	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
321314012842	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012843	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
321314012844	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012845	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
321314012846	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012847	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
321314012848	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
321314012849	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
321314012850	Walker A/P-loop; other site
321314012851	ATP binding site [chemical binding]; other site
321314012852	Q-loop/lid; other site
321314012853	ABC transporter signature motif; other site
321314012854	Walker B; other site
321314012855	D-loop; other site
321314012856	H-loop/switch region; other site
321314012857	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
321314012858	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
321314012859	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
321314012860	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
321314012861	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012862	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
321314012863	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
321314012864	DNA binding residues [nucleotide binding]
321314012865	dimer interface [polypeptide binding]; other site
321314012866	[2Fe-2S] cluster binding site [ion binding]; other site
321314012867	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
321314012868	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
321314012869	putative C-terminal domain interface [polypeptide binding]; other site
321314012870	putative GSH binding site (G-site) [chemical binding]; other site
321314012871	putative dimer interface [polypeptide binding]; other site
321314012872	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
321314012873	putative N-terminal domain interface [polypeptide binding]; other site
321314012874	putative dimer interface [polypeptide binding]; other site
321314012875	putative substrate binding pocket (H-site) [chemical binding]; other site
321314012876	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
321314012877	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
321314012878	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
321314012879	Transcriptional regulator [Transcription]; Region: LysR; COG0583
321314012880	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314012881	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
321314012882	putative dimerization interface [polypeptide binding]; other site
321314012883	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
321314012884	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
321314012885	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
321314012886	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
321314012887	Na binding site [ion binding]; other site
321314012888	Predicted membrane protein [Function unknown]; Region: COG3162
321314012889	acetyl-CoA synthetase; Provisional; Region: PRK00174
321314012890	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
321314012891	active site
321314012892	CoA binding site [chemical binding]; other site
321314012893	acyl-activating enzyme (AAE) consensus motif; other site
321314012894	AMP binding site [chemical binding]; other site
321314012895	acetate binding site [chemical binding]; other site
321314012896	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
321314012897	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
321314012898	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
321314012899	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
321314012900	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
321314012901	heme lyase subunit NrfE; Provisional; Region: PRK10369
321314012902	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
321314012903	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
321314012904	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
321314012905	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
321314012906	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
321314012907	Sel1-like repeats; Region: SEL1; smart00671
321314012908	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
321314012909	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314012910	Coenzyme A binding pocket [chemical binding]; other site
321314012911	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
321314012912	dimer interface [polypeptide binding]; other site
321314012913	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
321314012914	hypothetical protein; Provisional; Region: PRK10220
321314012915	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
321314012916	PhnA protein; Region: PhnA; pfam03831
321314012917	proline/glycine betaine transporter; Provisional; Region: PRK10642
321314012918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314012919	putative substrate translocation pore; other site
321314012920	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
321314012921	sensor protein BasS/PmrB; Provisional; Region: PRK10755
321314012922	HAMP domain; Region: HAMP; pfam00672
321314012923	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314012924	dimer interface [polypeptide binding]; other site
321314012925	phosphorylation site [posttranslational modification]
321314012926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314012927	ATP binding site [chemical binding]; other site
321314012928	Mg2+ binding site [ion binding]; other site
321314012929	G-X-G motif; other site
321314012930	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
321314012931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314012932	active site
321314012933	phosphorylation site [posttranslational modification]
321314012934	intermolecular recognition site; other site
321314012935	dimerization interface [polypeptide binding]; other site
321314012936	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314012937	DNA binding site [nucleotide binding]
321314012938	putative metal dependent hydrolase; Provisional; Region: PRK11598
321314012939	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
321314012940	Sulfatase; Region: Sulfatase; pfam00884
321314012941	arginine:agmatin antiporter; Provisional; Region: PRK10644
321314012942	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
321314012943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012944	arginine decarboxylase; Provisional; Region: PRK15029
321314012945	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
321314012946	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
321314012947	homodimer interface [polypeptide binding]; other site
321314012948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
321314012949	catalytic residue [active]
321314012950	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
321314012951	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
321314012952	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012953	alpha-galactosidase; Provisional; Region: PRK15076
321314012954	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
321314012955	NAD binding site [chemical binding]; other site
321314012956	sugar binding site [chemical binding]; other site
321314012957	divalent metal binding site [ion binding]; other site
321314012958	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
321314012959	dimer interface [polypeptide binding]; other site
321314012960	melibiose:sodium symporter; Provisional; Region: PRK10429
321314012961	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
321314012962	fumarate hydratase; Provisional; Region: PRK15389
321314012963	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
321314012964	Fumarase C-terminus; Region: Fumerase_C; pfam05683
321314012965	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
321314012966	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
321314012967	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
321314012968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314012969	active site
321314012970	phosphorylation site [posttranslational modification]
321314012971	intermolecular recognition site; other site
321314012972	dimerization interface [polypeptide binding]; other site
321314012973	sensory histidine kinase DcuS; Provisional; Region: PRK11086
321314012974	PAS domain; Region: PAS; smart00091
321314012975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314012976	ATP binding site [chemical binding]; other site
321314012977	Mg2+ binding site [ion binding]; other site
321314012978	G-X-G motif; other site
321314012979	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
321314012980	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
321314012981	putative [Fe4-S4] binding site [ion binding]; other site
321314012982	putative molybdopterin cofactor binding site [chemical binding]; other site
321314012983	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
321314012984	putative molybdopterin cofactor binding site; other site
321314012985	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
321314012986	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
321314012987	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
321314012988	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
321314012989	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
321314012990	SdiA-regulated; Region: SdiA-regulated; cd09971
321314012991	putative active site [active]
321314012992	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
321314012993	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314012994	DNA binding residues [nucleotide binding]
321314012995	dimerization interface [polypeptide binding]; other site
321314012996	AraC family transcriptional regulator; Provisional; Region: PRK15186
321314012997	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314012998	similar to IS3
321314012999	similar to IS3
321314013000	similar to IS3
321314013001	similar to IS3
321314013002	similar to IS3
321314013003	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
321314013004	similar to IS285
321314013005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
321314013006	similar to IS285
321314013007	similar to IS285
321314013008	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
321314013009	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
321314013010	active site
321314013011	putative transcriptional regulator; Provisional; Region: PRK11640
321314013012	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
321314013013	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
321314013014	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
321314013015	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
321314013016	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
321314013017	DsbD alpha interface [polypeptide binding]; other site
321314013018	catalytic residues [active]
321314013019	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
321314013020	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
321314013021	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
321314013022	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
321314013023	Aspartase; Region: Aspartase; cd01357
321314013024	active sites [active]
321314013025	tetramer interface [polypeptide binding]; other site
321314013026	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
321314013027	putative transporter; Provisional; Region: PRK11021
321314013028	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
321314013029	oligomerisation interface [polypeptide binding]; other site
321314013030	mobile loop; other site
321314013031	roof hairpin; other site
321314013032	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
321314013033	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
321314013034	ring oligomerisation interface [polypeptide binding]; other site
321314013035	ATP/Mg binding site [chemical binding]; other site
321314013036	stacking interactions; other site
321314013037	hinge regions; other site
321314013038	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
321314013039	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
321314013040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314013041	FeS/SAM binding site; other site
321314013042	elongation factor P; Validated; Region: PRK00529
321314013043	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
321314013044	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
321314013045	RNA binding site [nucleotide binding]; other site
321314013046	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
321314013047	RNA binding site [nucleotide binding]; other site
321314013048	Predicted small secreted protein [Function unknown]; Region: COG5510
321314013049	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
321314013050	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
321314013051	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314013052	DNA binding residues [nucleotide binding]
321314013053	dimerization interface [polypeptide binding]; other site
321314013054	multidrug efflux system protein; Provisional; Region: PRK11431
321314013055	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
321314013056	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
321314013057	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
321314013058	Iron-sulfur protein interface; other site
321314013059	proximal quinone binding site [chemical binding]; other site
321314013060	C-subunit interface; other site
321314013061	distal quinone binding site; other site
321314013062	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
321314013063	D-subunit interface [polypeptide binding]; other site
321314013064	Iron-sulfur protein interface; other site
321314013065	proximal quinone binding site [chemical binding]; other site
321314013066	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
321314013067	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
321314013068	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
321314013069	L-aspartate oxidase; Provisional; Region: PRK06175
321314013070	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
321314013071	poxB regulator PoxA; Provisional; Region: PRK09350
321314013072	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
321314013073	motif 1; other site
321314013074	dimer interface [polypeptide binding]; other site
321314013075	active site
321314013076	motif 2; other site
321314013077	motif 3; other site
321314013078	inner membrane transporter YjeM; Provisional; Region: PRK15238
321314013079	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
321314013080	putative mechanosensitive channel protein; Provisional; Region: PRK10929
321314013081	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
321314013082	Mechanosensitive ion channel; Region: MS_channel; pfam00924
321314013083	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
321314013084	GTPase RsgA; Reviewed; Region: PRK12288
321314013085	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
321314013086	RNA binding site [nucleotide binding]; other site
321314013087	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
321314013088	GTPase/Zn-binding domain interface [polypeptide binding]; other site
321314013089	GTP/Mg2+ binding site [chemical binding]; other site
321314013090	G4 box; other site
321314013091	G5 box; other site
321314013092	G1 box; other site
321314013093	Switch I region; other site
321314013094	G2 box; other site
321314013095	G3 box; other site
321314013096	Switch II region; other site
321314013097	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
321314013098	catalytic site [active]
321314013099	putative active site [active]
321314013100	putative substrate binding site [chemical binding]; other site
321314013101	dimer interface [polypeptide binding]; other site
321314013102	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
321314013103	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
321314013104	substrate binding pocket [chemical binding]; other site
321314013105	membrane-bound complex binding site; other site
321314013106	hinge residues; other site
321314013107	epoxyqueuosine reductase; Region: TIGR00276
321314013108	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
321314013109	putative carbohydrate kinase; Provisional; Region: PRK10565
321314013110	Uncharacterized conserved protein [Function unknown]; Region: COG0062
321314013111	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
321314013112	putative substrate binding site [chemical binding]; other site
321314013113	putative ATP binding site [chemical binding]; other site
321314013114	ADP-binding protein; Provisional; Region: PRK10646
321314013115	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
321314013116	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
321314013117	active site
321314013118	metal binding site [ion binding]; metal-binding site
321314013119	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
321314013120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314013121	ATP binding site [chemical binding]; other site
321314013122	Mg2+ binding site [ion binding]; other site
321314013123	G-X-G motif; other site
321314013124	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
321314013125	ATP binding site [chemical binding]; other site
321314013126	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
321314013127	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
321314013128	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
321314013129	bacterial Hfq-like; Region: Hfq; cd01716
321314013130	hexamer interface [polypeptide binding]; other site
321314013131	Sm1 motif; other site
321314013132	RNA binding site [nucleotide binding]; other site
321314013133	Sm2 motif; other site
321314013134	GTPase HflX; Provisional; Region: PRK11058
321314013135	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
321314013136	HflX GTPase family; Region: HflX; cd01878
321314013137	G1 box; other site
321314013138	GTP/Mg2+ binding site [chemical binding]; other site
321314013139	Switch I region; other site
321314013140	G2 box; other site
321314013141	G3 box; other site
321314013142	Switch II region; other site
321314013143	G4 box; other site
321314013144	G5 box; other site
321314013145	FtsH protease regulator HflK; Provisional; Region: PRK10930
321314013146	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
321314013147	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
321314013148	FtsH protease regulator HflC; Provisional; Region: PRK11029
321314013149	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
321314013150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
321314013151	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
321314013152	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
321314013153	GDP-binding site [chemical binding]; other site
321314013154	ACT binding site; other site
321314013155	IMP binding site; other site
321314013156	Predicted transcriptional regulator [Transcription]; Region: COG1959
321314013157	transcriptional repressor NsrR; Provisional; Region: PRK11014
321314013158	exoribonuclease R; Provisional; Region: PRK11642
321314013159	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
321314013160	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
321314013161	RNB domain; Region: RNB; pfam00773
321314013162	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
321314013163	RNA binding site [nucleotide binding]; other site
321314013164	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
321314013165	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
321314013166	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
321314013167	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789
321314013168	Ion channel; Region: Ion_trans_2; pfam07885
321314013169	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
321314013170	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
321314013171	Predicted membrane protein [Function unknown]; Region: COG3766
321314013172	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
321314013173	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
321314013174	Predicted integral membrane protein [Function unknown]; Region: COG5463
321314013175	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
321314013176	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
321314013177	FAD binding site [chemical binding]; other site
321314013178	substrate binding site [chemical binding]; other site
321314013179	catalytic residues [active]
321314013180	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314013181	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
321314013182	esterase; Provisional; Region: PRK10566
321314013183	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
321314013184	transcriptional repressor UlaR; Provisional; Region: PRK13509
321314013185	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
321314013186	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
321314013187	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
321314013188	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
321314013189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
321314013190	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
321314013191	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
321314013192	active site
321314013193	P-loop; other site
321314013194	phosphorylation site [posttranslational modification]
321314013195	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314013196	active site
321314013197	phosphorylation site [posttranslational modification]
321314013198	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
321314013199	active site
321314013200	dimer interface [polypeptide binding]; other site
321314013201	magnesium binding site [ion binding]; other site
321314013202	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
321314013203	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
321314013204	AP (apurinic/apyrimidinic) site pocket; other site
321314013205	DNA interaction; other site
321314013206	Metal-binding active site; metal-binding site
321314013207	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
321314013208	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
321314013209	intersubunit interface [polypeptide binding]; other site
321314013210	active site
321314013211	Zn2+ binding site [ion binding]; other site
321314013212	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
321314013213	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
321314013214	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
321314013215	dimer interface [polypeptide binding]; other site
321314013216	ssDNA binding site [nucleotide binding]; other site
321314013217	tetramer (dimer of dimers) interface [polypeptide binding]; other site
321314013218	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
321314013219	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
321314013220	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
321314013221	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
321314013222	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
321314013223	EamA-like transporter family; Region: EamA; pfam00892
321314013224	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
321314013225	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
321314013226	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
321314013227	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
321314013228	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
321314013229	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
321314013230	DKNYY family; Region: DKNYY; pfam13644
321314013231	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
321314013232	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
321314013233	Hemerythrin-like domain; Region: Hr-like; cd12108
321314013234	Fe binding site [ion binding]; other site
321314013235	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
321314013236	EamA-like transporter family; Region: EamA; pfam00892
321314013237	Predicted transcriptional regulators [Transcription]; Region: COG1733
321314013238	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
321314013239	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
321314013240	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
321314013241	active site
321314013242	metal binding site [ion binding]; metal-binding site
321314013243	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
321314013244	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
321314013245	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
321314013246	active site
321314013247	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
321314013248	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
321314013249	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
321314013250	Domain of unknown function DUF21; Region: DUF21; pfam01595
321314013251	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
321314013252	Transporter associated domain; Region: CorC_HlyC; smart01091
321314013253	methionine sulfoxide reductase A; Provisional; Region: PRK00058
321314013254	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
321314013255	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
321314013256	Surface antigen; Region: Bac_surface_Ag; pfam01103
321314013257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
321314013258	Family of unknown function (DUF490); Region: DUF490; pfam04357
321314013259	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
321314013260	putative active site pocket [active]
321314013261	dimerization interface [polypeptide binding]; other site
321314013262	putative catalytic residue [active]
321314013263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314013264	D-galactonate transporter; Region: 2A0114; TIGR00893
321314013265	putative substrate translocation pore; other site
321314013266	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
321314013267	dimer interface [polypeptide binding]; other site
321314013268	substrate binding site [chemical binding]; other site
321314013269	metal binding sites [ion binding]; metal-binding site
321314013270	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
321314013271	AMP binding site [chemical binding]; other site
321314013272	metal binding site [ion binding]; metal-binding site
321314013273	active site
321314013274	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
321314013275	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
321314013276	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
321314013277	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
321314013278	hypothetical protein; Provisional; Region: PRK05255
321314013279	peptidase PmbA; Provisional; Region: PRK11040
321314013280	cytochrome b562; Provisional; Region: PRK15058
321314013281	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
321314013282	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
321314013283	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
321314013284	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
321314013285	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
321314013286	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
321314013287	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
321314013288	active site
321314013289	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
321314013290	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
321314013291	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
321314013292	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
321314013293	HTH domain; Region: HTH_11; pfam08279
321314013294	Mga helix-turn-helix domain; Region: Mga; pfam05043
321314013295	PRD domain; Region: PRD; pfam00874
321314013296	PRD domain; Region: PRD; pfam00874
321314013297	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
321314013298	active site
321314013299	P-loop; other site
321314013300	phosphorylation site [posttranslational modification]
321314013301	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
321314013302	active site
321314013303	phosphorylation site [posttranslational modification]
321314013304	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
321314013305	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
321314013306	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
321314013307	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314013308	FeS/SAM binding site; other site
321314013309	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
321314013310	ATP cone domain; Region: ATP-cone; pfam03477
321314013311	Class III ribonucleotide reductase; Region: RNR_III; cd01675
321314013312	effector binding site; other site
321314013313	active site
321314013314	Zn binding site [ion binding]; other site
321314013315	glycine loop; other site
321314013316	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
321314013317	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
321314013318	Ca binding site [ion binding]; other site
321314013319	active site
321314013320	catalytic site [active]
321314013321	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
321314013322	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
321314013323	active site turn [active]
321314013324	phosphorylation site [posttranslational modification]
321314013325	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
321314013326	trehalose repressor; Provisional; Region: treR; PRK09492
321314013327	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314013328	DNA binding site [nucleotide binding]
321314013329	domain linker motif; other site
321314013330	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
321314013331	dimerization interface [polypeptide binding]; other site
321314013332	ligand binding site [chemical binding]; other site
321314013333	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
321314013334	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
321314013335	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
321314013336	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
321314013337	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
321314013338	Soluble P-type ATPase [General function prediction only]; Region: COG4087
321314013339	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
321314013340	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
321314013341	homotrimer interaction site [polypeptide binding]; other site
321314013342	putative active site [active]
321314013343	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
321314013344	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
321314013345	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
321314013346	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
321314013347	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
321314013348	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
321314013349	Arginine repressor [Transcription]; Region: ArgR; COG1438
321314013350	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
321314013351	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
321314013352	Predicted membrane protein [Function unknown]; Region: COG1288
321314013353	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
321314013354	ornithine carbamoyltransferase; Validated; Region: PRK02102
321314013355	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
321314013356	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
321314013357	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
321314013358	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
321314013359	putative substrate binding site [chemical binding]; other site
321314013360	nucleotide binding site [chemical binding]; other site
321314013361	nucleotide binding site [chemical binding]; other site
321314013362	homodimer interface [polypeptide binding]; other site
321314013363	arginine deiminase; Provisional; Region: PRK01388
321314013364	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
321314013365	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
321314013366	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
321314013367	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
321314013368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
321314013369	RNase E inhibitor protein; Provisional; Region: PRK11191
321314013370	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
321314013371	active site
321314013372	dinuclear metal binding site [ion binding]; other site
321314013373	dimerization interface [polypeptide binding]; other site
321314013374	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
321314013375	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
321314013376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314013377	Coenzyme A binding pocket [chemical binding]; other site
321314013378	Predicted membrane protein [Function unknown]; Region: COG4269
321314013379	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
321314013380	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
321314013381	HIGH motif; other site
321314013382	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
321314013383	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
321314013384	active site
321314013385	KMSKS motif; other site
321314013386	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
321314013387	tRNA binding surface [nucleotide binding]; other site
321314013388	anticodon binding site; other site
321314013389	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
321314013390	DNA polymerase III subunit chi; Validated; Region: PRK05728
321314013391	multifunctional aminopeptidase A; Provisional; Region: PRK00913
321314013392	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
321314013393	interface (dimer of trimers) [polypeptide binding]; other site
321314013394	Substrate-binding/catalytic site; other site
321314013395	Zn-binding sites [ion binding]; other site
321314013396	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
321314013397	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
321314013398	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
321314013399	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
321314013400	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
321314013401	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
321314013402	DNA binding site [nucleotide binding]
321314013403	domain linker motif; other site
321314013404	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
321314013405	putative dimerization interface [polypeptide binding]; other site
321314013406	putative ligand binding site [chemical binding]; other site
321314013407	gluconate transporter; Region: gntP; TIGR00791
321314013408	fructuronate transporter; Provisional; Region: PRK10034; cl15264
321314013409	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
321314013410	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
321314013411	NADP binding site [chemical binding]; other site
321314013412	homodimer interface [polypeptide binding]; other site
321314013413	active site
321314013414	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
321314013415	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
321314013416	putative NAD(P) binding site [chemical binding]; other site
321314013417	catalytic Zn binding site [ion binding]; other site
321314013418	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
321314013419	ATP-binding site [chemical binding]; other site
321314013420	Gluconate-6-phosphate binding site [chemical binding]; other site
321314013421	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
321314013422	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
321314013423	putative NAD(P) binding site [chemical binding]; other site
321314013424	putative substrate binding site [chemical binding]; other site
321314013425	catalytic Zn binding site [ion binding]; other site
321314013426	structural Zn binding site [ion binding]; other site
321314013427	dimer interface [polypeptide binding]; other site
321314013428	Replicase family; Region: Replicase; pfam03090
321314013429	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
321314013430	DNA methylase; Region: N6_N4_Mtase; cl17433
321314013431	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
321314013432	HNH endonuclease; Region: HNH_2; pfam13391
321314013433	hypothetical protein; Provisional; Region: PRK12378
321314013434	Methyltransferase domain; Region: Methyltransf_23; pfam13489
321314013435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314013436	S-adenosylmethionine binding site [chemical binding]; other site
321314013437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314013438	S-adenosylmethionine binding site [chemical binding]; other site
321314013439	hypothetical protein; Provisional; Region: PRK13687
321314013440	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
321314013441	Uncharacterized conserved protein [Function unknown]; Region: COG3439
321314013442	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
321314013443	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
321314013444	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
321314013445	DNA-binding site [nucleotide binding]; DNA binding site
321314013446	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
321314013447	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
321314013448	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
321314013449	active site
321314013450	HIGH motif; other site
321314013451	dimer interface [polypeptide binding]; other site
321314013452	KMSKS motif; other site
321314013453	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
321314013454	aspartate racemase; Region: asp_race; TIGR00035
321314013455	cell density-dependent motility repressor; Provisional; Region: PRK10082
321314013456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
321314013457	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
321314013458	dimerization interface [polypeptide binding]; other site
321314013459	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
321314013460	isoaspartyl dipeptidase; Provisional; Region: PRK10657
321314013461	dimer interface [polypeptide binding]; other site
321314013462	active site
321314013463	hypothetical protein; Provisional; Region: PRK10519
321314013464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
321314013465	Nucleoside recognition; Region: Gate; pfam07670
321314013466	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
321314013467	Predicted membrane protein [Function unknown]; Region: COG2733
321314013468	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
321314013469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
321314013470	putative substrate translocation pore; other site
321314013471	putative transposase; Provisional; Region: PRK09857
321314013472	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
321314013473	Integrase core domain; Region: rve; pfam00665
321314013474	Integrase core domain; Region: rve_3; pfam13683
321314013475	Helix-turn-helix domain; Region: HTH_28; pfam13518
321314013476	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
321314013477	endoribonuclease SymE; Provisional; Region: PRK13605
321314013478	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
321314013479	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
321314013480	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
321314013481	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314013482	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
321314013483	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
321314013484	P-loop, Walker A motif; other site
321314013485	Base recognition motif; other site
321314013486	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
321314013487	Uncharacterized small protein [Function unknown]; Region: COG2879
321314013488	carbon starvation protein A; Provisional; Region: PRK15015
321314013489	Carbon starvation protein CstA; Region: CstA; pfam02554
321314013490	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
321314013491	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
321314013492	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
321314013493	dimer interface [polypeptide binding]; other site
321314013494	ligand binding site [chemical binding]; other site
321314013495	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
321314013496	dimerization interface [polypeptide binding]; other site
321314013497	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
321314013498	dimer interface [polypeptide binding]; other site
321314013499	putative CheW interface [polypeptide binding]; other site
321314013500	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
321314013501	active pocket/dimerization site; other site
321314013502	active site
321314013503	phosphorylation site [posttranslational modification]
321314013504	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
321314013505	active site
321314013506	phosphorylation site [posttranslational modification]
321314013507	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
321314013508	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
321314013509	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
321314013510	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
321314013511	dimer interface [polypeptide binding]; other site
321314013512	active site
321314013513	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
321314013514	dimer interface [polypeptide binding]; other site
321314013515	active site
321314013516	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
321314013517	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
321314013518	putative active site [active]
321314013519	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
321314013520	phosphoglycerol transferase I; Provisional; Region: PRK03776
321314013521	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
321314013522	hypothetical protein; Provisional; Region: PRK11667
321314013523	DNA replication protein DnaC; Validated; Region: PRK07952
321314013524	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
321314013525	Walker A motif; other site
321314013526	ATP binding site [chemical binding]; other site
321314013527	Walker B motif; other site
321314013528	primosomal protein DnaI; Provisional; Region: PRK02854
321314013529	hypothetical protein; Provisional; Region: PRK09917
321314013530	Uncharacterized conserved protein [Function unknown]; Region: COG2966
321314013531	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
321314013532	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
321314013533	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
321314013534	DNA binding residues [nucleotide binding]
321314013535	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
321314013536	putative deacylase active site [active]
321314013537	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
321314013538	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
321314013539	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
321314013540	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
321314013541	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
321314013542	metal binding site [ion binding]; metal-binding site
321314013543	active site
321314013544	I-site; other site
321314013545	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
321314013546	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
321314013547	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
321314013548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
321314013549	S-adenosylmethionine binding site [chemical binding]; other site
321314013550	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
321314013551	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
321314013552	Coenzyme A binding pocket [chemical binding]; other site
321314013553	dUMP phosphatase; Provisional; Region: PRK09449
321314013554	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314013555	motif II; other site
321314013556	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
321314013557	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
321314013558	G1 box; other site
321314013559	putative GEF interaction site [polypeptide binding]; other site
321314013560	GTP/Mg2+ binding site [chemical binding]; other site
321314013561	Switch I region; other site
321314013562	G2 box; other site
321314013563	G3 box; other site
321314013564	Switch II region; other site
321314013565	G4 box; other site
321314013566	G5 box; other site
321314013567	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
321314013568	periplasmic protein; Provisional; Region: PRK10568
321314013569	BON domain; Region: BON; pfam04972
321314013570	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
321314013571	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
321314013572	active site
321314013573	nucleophile elbow; other site
321314013574	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
321314013575	active site
321314013576	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
321314013577	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
321314013578	FeS/SAM binding site; other site
321314013579	hypothetical protein; Provisional; Region: PRK10977
321314013580	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
321314013581	intersubunit interface [polypeptide binding]; other site
321314013582	active site
321314013583	catalytic residue [active]
321314013584	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
321314013585	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
321314013586	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
321314013587	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
321314013588	phosphopentomutase; Provisional; Region: PRK05362
321314013589	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
321314013590	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
321314013591	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
321314013592	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
321314013593	HipA-like C-terminal domain; Region: HipA_C; pfam07804
321314013594	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
321314013595	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
321314013596	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
321314013597	hypothetical protein; Provisional; Region: PRK11246
321314013598	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
321314013599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
321314013600	motif II; other site
321314013601	DNA repair protein RadA; Region: sms; TIGR00416
321314013602	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
321314013603	Walker A motif/ATP binding site; other site
321314013604	ATP binding site [chemical binding]; other site
321314013605	Walker B motif; other site
321314013606	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
321314013607	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
321314013608	non-specific DNA binding site [nucleotide binding]; other site
321314013609	salt bridge; other site
321314013610	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
321314013611	sequence-specific DNA binding site [nucleotide binding]; other site
321314013612	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
321314013613	active site
321314013614	(T/H)XGH motif; other site
321314013615	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
321314013616	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
321314013617	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314013618	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314013619	ABC transporter; Region: ABC_tran_2; pfam12848
321314013620	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
321314013621	lytic murein transglycosylase; Provisional; Region: PRK11619
321314013622	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
321314013623	N-acetyl-D-glucosamine binding site [chemical binding]; other site
321314013624	catalytic residue [active]
321314013625	Trp operon repressor; Provisional; Region: PRK01381
321314013626	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
321314013627	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
321314013628	catalytic core [active]
321314013629	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
321314013630	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
321314013631	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
321314013632	hypothetical protein; Provisional; Region: PRK10756
321314013633	CreA protein; Region: CreA; pfam05981
321314013634	DNA-binding response regulator CreB; Provisional; Region: PRK11083
321314013635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314013636	active site
321314013637	phosphorylation site [posttranslational modification]
321314013638	intermolecular recognition site; other site
321314013639	dimerization interface [polypeptide binding]; other site
321314013640	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314013641	DNA binding site [nucleotide binding]
321314013642	sensory histidine kinase CreC; Provisional; Region: PRK11100
321314013643	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
321314013644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
321314013645	dimer interface [polypeptide binding]; other site
321314013646	phosphorylation site [posttranslational modification]
321314013647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
321314013648	ATP binding site [chemical binding]; other site
321314013649	Mg2+ binding site [ion binding]; other site
321314013650	G-X-G motif; other site
321314013651	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
321314013652	putative major fimbrial protein SthE; Provisional; Region: PRK15292
321314013653	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
321314013654	putative fimbrial protein SthD; Provisional; Region: PRK15293
321314013655	putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294
321314013656	PapC N-terminal domain; Region: PapC_N; pfam13954
321314013657	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
321314013658	PapC C-terminal domain; Region: PapC_C; pfam13953
321314013659	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
321314013660	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
321314013661	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
321314013662	putative fimbrial protein SthA; Provisional; Region: PRK15296
321314013663	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
321314013664	Helix-turn-helix domain; Region: HTH_36; pfam13730
321314013665	two-component response regulator; Provisional; Region: PRK11173
321314013666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
321314013667	active site
321314013668	phosphorylation site [posttranslational modification]
321314013669	intermolecular recognition site; other site
321314013670	dimerization interface [polypeptide binding]; other site
321314013671	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
321314013672	DNA binding site [nucleotide binding]
321314013673	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
321314013674	putative RNA methyltransferase; Provisional; Region: PRK10433