-- dump date   	20140620_045654
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
439851000001	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
439851000002	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
439851000003	active site clefts [active]
439851000004	zinc binding site [ion binding]; other site
439851000005	dimer interface [polypeptide binding]; other site
439851000006	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
439851000007	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
439851000008	catalytic residues [active]
439851000009	catalytic nucleophile [active]
439851000010	Presynaptic Site I dimer interface [polypeptide binding]; other site
439851000011	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
439851000012	Synaptic Flat tetramer interface [polypeptide binding]; other site
439851000013	Synaptic Site I dimer interface [polypeptide binding]; other site
439851000014	DNA binding site [nucleotide binding]
439851000015	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
439851000016	DNA-binding interface [nucleotide binding]; DNA binding site
439851000017	Integrase core domain; Region: rve; pfam00665
439851000018	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
439851000019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851000020	Walker A/P-loop; other site
439851000021	Homeodomain-like domain; Region: HTH_23; pfam13384
439851000022	Winged helix-turn helix; Region: HTH_29; pfam13551
439851000023	Homeodomain-like domain; Region: HTH_32; pfam13565
439851000024	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
439851000025	DDE superfamily endonuclease; Region: DDE_3; pfam13358
439851000026	transcriptional regulator SpvR; Provisional; Region: PRK15243
439851000027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851000028	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851000029	virulence protein SpvA; Provisional; Region: PRK15212
439851000030	Salmonella virulence-associated 28kDa protein; Region: VRP3; cl04142
439851000031	virulence protein SpvD; Provisional; Region: PRK15250
439851000032	Transposase IS200 like; Region: Y1_Tnp; pfam01797
439851000033	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
439851000034	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851000035	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
439851000036	active site
439851000037	catalytic residues [active]
439851000038	DNA binding site [nucleotide binding]
439851000039	Int/Topo IB signature motif; other site
439851000040	plasmid maintenance protein CcdB; Provisional; Region: PRK13708
439851000041	plasmid maintenance protein CcdA; Provisional; Region: PRK13710
439851000042	SdiA-regulated; Region: SdiA-regulated; pfam06977
439851000043	SdiA-regulated; Region: SdiA-regulated; cd09971
439851000044	putative active site [active]
439851000045	FaeA-like protein; Region: FaeA; pfam04703
439851000046	LytTr DNA-binding domain; Region: LytTR; cl04498
439851000047	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
439851000048	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
439851000049	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
439851000050	replication protein; Provisional; Region: PRK13750
439851000051	replication protein; Provisional; Region: PRK13702
439851000052	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
439851000053	conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754
439851000054	Fertility inhibition protein N terminal; Region: FinO_N; pfam12602
439851000055	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236
439851000056	putative RNA binding sites [nucleotide binding]; other site
439851000057	conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706
439851000058	conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709
439851000059	AAA domain; Region: AAA_30; pfam13604
439851000060	DNA helicase TraI; Region: TraI; pfam07057
439851000061	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
439851000062	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
439851000063	catalytic residues [active]
439851000064	catalytic nucleophile [active]
439851000065	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
439851000066	DNA-binding interface [nucleotide binding]; DNA binding site
439851000067	Haemolysin expression modulating protein; Region: HHA; pfam05321
439851000068	DNA topoisomerase III; Provisional; Region: PRK07726
439851000069	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
439851000070	active site
439851000071	putative interdomain interaction site [polypeptide binding]; other site
439851000072	putative metal-binding site [ion binding]; other site
439851000073	putative nucleotide binding site [chemical binding]; other site
439851000074	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
439851000075	domain I; other site
439851000076	DNA binding groove [nucleotide binding]
439851000077	phosphate binding site [ion binding]; other site
439851000078	domain II; other site
439851000079	domain III; other site
439851000080	nucleotide binding site [chemical binding]; other site
439851000081	catalytic site [active]
439851000082	domain IV; other site
439851000083	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
439851000084	TrbM; Region: TrbM; pfam07424
439851000085	Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117
439851000086	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
439851000087	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
439851000088	Walker A motif; other site
439851000089	ATP binding site [chemical binding]; other site
439851000090	Walker B motif; other site
439851000091	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
439851000092	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
439851000093	VirB7 interaction site; other site
439851000094	VirB8 protein; Region: VirB8; pfam04335
439851000095	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
439851000096	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
439851000097	Type IV secretion system proteins; Region: T4SS; pfam07996
439851000098	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
439851000099	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
439851000100	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
439851000101	TrbC/VIRB2 family; Region: TrbC; pfam04956
439851000102	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439851000103	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851000104	catalytic residue [active]
439851000105	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
439851000106	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
439851000107	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
439851000108	primosomal protein DnaI; Provisional; Region: PRK02854
439851000109	RelB antitoxin; Region: RelB; cl01171
439851000110	Initiator Replication protein; Region: Rep_3; pfam01051
439851000111	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
439851000112	ParG; Region: ParG; pfam09274
439851000113	ParA-like protein; Provisional; Region: PHA02518
439851000114	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
439851000115	P-loop; other site
439851000116	Magnesium ion binding site [ion binding]; other site
439851000117	Threonine operon leader
439851000118	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
439851000119	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
439851000120	putative catalytic residues [active]
439851000121	putative nucleotide binding site [chemical binding]; other site
439851000122	putative aspartate binding site [chemical binding]; other site
439851000123	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
439851000124	dimer interface [polypeptide binding]; other site
439851000125	putative threonine allosteric regulatory site; other site
439851000126	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
439851000127	putative threonine allosteric regulatory site; other site
439851000128	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
439851000129	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
439851000130	homoserine kinase; Provisional; Region: PRK01212
439851000131	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
439851000132	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
439851000133	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
439851000134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851000135	catalytic residue [active]
439851000136	hypothetical protein; Validated; Region: PRK02101
439851000137	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
439851000138	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
439851000139	transaldolase-like protein; Provisional; Region: PTZ00411
439851000140	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
439851000141	active site
439851000142	dimer interface [polypeptide binding]; other site
439851000143	catalytic residue [active]
439851000144	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
439851000145	MPT binding site; other site
439851000146	trimer interface [polypeptide binding]; other site
439851000147	hypothetical protein; Provisional; Region: PRK10659
439851000148	hypothetical protein; Provisional; Region: PRK10236
439851000149	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
439851000150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
439851000151	Protein of unknown function (DUF2541); Region: DUF2541; cl08090
439851000152	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
439851000153	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
439851000154	nucleotide binding site [chemical binding]; other site
439851000155	chaperone protein DnaJ; Provisional; Region: PRK10767
439851000156	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
439851000157	HSP70 interaction site [polypeptide binding]; other site
439851000158	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
439851000159	substrate binding site [polypeptide binding]; other site
439851000160	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
439851000161	Zn binding sites [ion binding]; other site
439851000162	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
439851000163	dimer interface [polypeptide binding]; other site
439851000164	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851000165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851000166	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
439851000167	substrate binding pocket [chemical binding]; other site
439851000168	dimerization interface [polypeptide binding]; other site
439851000169	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
439851000170	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
439851000171	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
439851000172	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
439851000173	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
439851000174	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
439851000175	active site
439851000176	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
439851000177	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
439851000178	aromatic chitin/cellulose binding site residues [chemical binding]; other site
439851000179	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
439851000180	Helix-turn-helix domain; Region: HTH_36; pfam13730
439851000181	fimbrial protein BcfA; Provisional; Region: PRK15187
439851000182	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
439851000183	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851000184	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851000185	outer membrane usher protein; Provisional; Region: PRK15193
439851000186	PapC N-terminal domain; Region: PapC_N; pfam13954
439851000187	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851000188	PapC C-terminal domain; Region: PapC_C; pfam13953
439851000189	fimbrial protein BcfD; Provisional; Region: PRK15189
439851000190	fimbrial protein BcfE; Provisional; Region: PRK15190
439851000191	fimbrial protein BcfF; Provisional; Region: PRK15191
439851000192	fimbrial chaperone BcfG; Provisional; Region: PRK15192
439851000193	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851000194	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851000195	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
439851000196	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851000197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851000198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851000199	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
439851000200	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439851000201	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
439851000202	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
439851000203	active site
439851000204	metal binding site [ion binding]; metal-binding site
439851000205	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439851000206	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
439851000207	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
439851000208	Sulfatase; Region: Sulfatase; pfam00884
439851000209	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439851000210	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851000211	FeS/SAM binding site; other site
439851000212	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439851000213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
439851000214	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439851000215	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
439851000216	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
439851000217	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851000218	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
439851000219	putative dimerization interface [polypeptide binding]; other site
439851000220	putative alpha-glucosidase; Provisional; Region: PRK10658
439851000221	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
439851000222	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
439851000223	putative active site [active]
439851000224	putative catalytic site [active]
439851000225	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
439851000226	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
439851000227	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
439851000228	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
439851000229	active site
439851000230	Riboflavin kinase; Region: Flavokinase; smart00904
439851000231	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
439851000232	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
439851000233	active site
439851000234	HIGH motif; other site
439851000235	nucleotide binding site [chemical binding]; other site
439851000236	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
439851000237	active site
439851000238	KMSKS motif; other site
439851000239	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
439851000240	tRNA binding surface [nucleotide binding]; other site
439851000241	anticodon binding site; other site
439851000242	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
439851000243	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
439851000244	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
439851000245	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439851000246	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
439851000247	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
439851000248	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
439851000249	active site
439851000250	tetramer interface [polypeptide binding]; other site
439851000251	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
439851000252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851000253	active site
439851000254	phosphorylation site [posttranslational modification]
439851000255	intermolecular recognition site; other site
439851000256	dimerization interface [polypeptide binding]; other site
439851000257	Transcriptional regulator; Region: CitT; pfam12431
439851000258	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
439851000259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851000260	ATP binding site [chemical binding]; other site
439851000261	Mg2+ binding site [ion binding]; other site
439851000262	G-X-G motif; other site
439851000263	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
439851000264	oxaloacetate decarboxylase; Provisional; Region: PRK14040
439851000265	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
439851000266	active site
439851000267	catalytic residues [active]
439851000268	metal binding site [ion binding]; metal-binding site
439851000269	homodimer binding site [polypeptide binding]; other site
439851000270	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
439851000271	carboxyltransferase (CT) interaction site; other site
439851000272	biotinylation site [posttranslational modification]; other site
439851000273	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
439851000274	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
439851000275	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
439851000276	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
439851000277	putative active site [active]
439851000278	(T/H)XGH motif; other site
439851000279	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
439851000280	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
439851000281	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
439851000282	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
439851000283	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
439851000284	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
439851000285	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
439851000286	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
439851000287	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
439851000288	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
439851000289	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
439851000290	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
439851000291	catalytic site [active]
439851000292	subunit interface [polypeptide binding]; other site
439851000293	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
439851000294	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
439851000295	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
439851000296	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
439851000297	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
439851000298	ATP-grasp domain; Region: ATP-grasp_4; cl17255
439851000299	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
439851000300	IMP binding site; other site
439851000301	dimer interface [polypeptide binding]; other site
439851000302	interdomain contacts; other site
439851000303	partial ornithine binding site; other site
439851000304	carnitine operon protein CaiE; Provisional; Region: PRK13627
439851000305	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
439851000306	putative trimer interface [polypeptide binding]; other site
439851000307	putative metal binding site [ion binding]; other site
439851000308	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
439851000309	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439851000310	substrate binding site [chemical binding]; other site
439851000311	oxyanion hole (OAH) forming residues; other site
439851000312	trimer interface [polypeptide binding]; other site
439851000313	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
439851000314	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
439851000315	acyl-activating enzyme (AAE) consensus motif; other site
439851000316	putative AMP binding site [chemical binding]; other site
439851000317	putative active site [active]
439851000318	putative CoA binding site [chemical binding]; other site
439851000319	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
439851000320	CoA-transferase family III; Region: CoA_transf_3; pfam02515
439851000321	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
439851000322	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
439851000323	active site
439851000324	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
439851000325	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
439851000326	Ligand binding site [chemical binding]; other site
439851000327	Electron transfer flavoprotein domain; Region: ETF; pfam01012
439851000328	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
439851000329	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
439851000330	Ligand binding site [chemical binding]; other site
439851000331	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
439851000332	putative oxidoreductase FixC; Provisional; Region: PRK10157
439851000333	ferredoxin-like protein FixX; Provisional; Region: PRK15449
439851000334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851000335	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
439851000336	putative substrate translocation pore; other site
439851000337	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439851000338	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
439851000339	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
439851000340	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
439851000341	TrkA-N domain; Region: TrkA_N; pfam02254
439851000342	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
439851000343	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
439851000344	folate binding site [chemical binding]; other site
439851000345	NADP+ binding site [chemical binding]; other site
439851000346	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
439851000347	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
439851000348	active site
439851000349	metal binding site [ion binding]; metal-binding site
439851000350	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
439851000351	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
439851000352	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
439851000353	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
439851000354	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
439851000355	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
439851000356	SurA N-terminal domain; Region: SurA_N; pfam09312
439851000357	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
439851000358	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
439851000359	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
439851000360	OstA-like protein; Region: OstA; pfam03968
439851000361	Organic solvent tolerance protein; Region: OstA_C; pfam04453
439851000362	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
439851000363	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
439851000364	putative metal binding site [ion binding]; other site
439851000365	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
439851000366	HSP70 interaction site [polypeptide binding]; other site
439851000367	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
439851000368	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
439851000369	active site
439851000370	ATP-dependent helicase HepA; Validated; Region: PRK04914
439851000371	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851000372	ATP binding site [chemical binding]; other site
439851000373	putative Mg++ binding site [ion binding]; other site
439851000374	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851000375	nucleotide binding region [chemical binding]; other site
439851000376	ATP-binding site [chemical binding]; other site
439851000377	DNA polymerase II; Reviewed; Region: PRK05762
439851000378	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
439851000379	active site
439851000380	catalytic site [active]
439851000381	substrate binding site [chemical binding]; other site
439851000382	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
439851000383	active site
439851000384	metal-binding site
439851000385	Uncharacterized conserved protein [Function unknown]; Region: COG1434
439851000386	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439851000387	putative active site [active]
439851000388	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
439851000389	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439851000390	intersubunit interface [polypeptide binding]; other site
439851000391	active site
439851000392	Zn2+ binding site [ion binding]; other site
439851000393	L-arabinose isomerase; Provisional; Region: PRK02929
439851000394	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
439851000395	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
439851000396	trimer interface [polypeptide binding]; other site
439851000397	putative substrate binding site [chemical binding]; other site
439851000398	putative metal binding site [ion binding]; other site
439851000399	ribulokinase; Provisional; Region: PRK04123
439851000400	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
439851000401	N- and C-terminal domain interface [polypeptide binding]; other site
439851000402	active site
439851000403	MgATP binding site [chemical binding]; other site
439851000404	catalytic site [active]
439851000405	metal binding site [ion binding]; metal-binding site
439851000406	carbohydrate binding site [chemical binding]; other site
439851000407	homodimer interface [polypeptide binding]; other site
439851000408	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
439851000409	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439851000410	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851000411	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851000412	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439851000413	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
439851000414	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
439851000415	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
439851000416	Walker A/P-loop; other site
439851000417	ATP binding site [chemical binding]; other site
439851000418	Q-loop/lid; other site
439851000419	ABC transporter signature motif; other site
439851000420	Walker B; other site
439851000421	D-loop; other site
439851000422	H-loop/switch region; other site
439851000423	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
439851000424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851000425	dimer interface [polypeptide binding]; other site
439851000426	conserved gate region; other site
439851000427	putative PBP binding loops; other site
439851000428	ABC-ATPase subunit interface; other site
439851000429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851000430	dimer interface [polypeptide binding]; other site
439851000431	conserved gate region; other site
439851000432	putative PBP binding loops; other site
439851000433	ABC-ATPase subunit interface; other site
439851000434	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
439851000435	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
439851000436	transcriptional regulator SgrR; Provisional; Region: PRK13626
439851000437	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
439851000438	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
439851000439	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
439851000440	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
439851000441	substrate binding site [chemical binding]; other site
439851000442	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
439851000443	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
439851000444	substrate binding site [chemical binding]; other site
439851000445	ligand binding site [chemical binding]; other site
439851000446	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
439851000447	tartrate dehydrogenase; Region: TTC; TIGR02089
439851000448	2-isopropylmalate synthase; Validated; Region: PRK00915
439851000449	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
439851000450	active site
439851000451	catalytic residues [active]
439851000452	metal binding site [ion binding]; metal-binding site
439851000453	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
439851000454	Leucine operon leader
439851000455	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
439851000456	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851000457	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
439851000458	putative substrate binding pocket [chemical binding]; other site
439851000459	putative dimerization interface [polypeptide binding]; other site
439851000460	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
439851000461	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
439851000462	PYR/PP interface [polypeptide binding]; other site
439851000463	dimer interface [polypeptide binding]; other site
439851000464	TPP binding site [chemical binding]; other site
439851000465	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439851000466	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
439851000467	TPP-binding site [chemical binding]; other site
439851000468	dimer interface [polypeptide binding]; other site
439851000469	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
439851000470	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
439851000471	putative valine binding site [chemical binding]; other site
439851000472	dimer interface [polypeptide binding]; other site
439851000473	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
439851000474	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
439851000475	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851000476	DNA binding site [nucleotide binding]
439851000477	domain linker motif; other site
439851000478	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
439851000479	dimerization interface [polypeptide binding]; other site
439851000480	ligand binding site [chemical binding]; other site
439851000481	mraZ protein; Region: TIGR00242
439851000482	MraZ protein; Region: MraZ; pfam02381
439851000483	MraZ protein; Region: MraZ; pfam02381
439851000484	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
439851000485	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
439851000486	cell division protein FtsL; Provisional; Region: PRK10772
439851000487	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
439851000488	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439851000489	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439851000490	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
439851000491	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439851000492	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439851000493	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439851000494	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
439851000495	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439851000496	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439851000497	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439851000498	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
439851000499	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
439851000500	Mg++ binding site [ion binding]; other site
439851000501	putative catalytic motif [active]
439851000502	putative substrate binding site [chemical binding]; other site
439851000503	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
439851000504	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439851000505	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439851000506	cell division protein FtsW; Provisional; Region: PRK10774
439851000507	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
439851000508	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
439851000509	active site
439851000510	homodimer interface [polypeptide binding]; other site
439851000511	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
439851000512	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439851000513	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439851000514	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439851000515	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
439851000516	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
439851000517	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
439851000518	cell division protein FtsQ; Provisional; Region: PRK10775
439851000519	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
439851000520	Cell division protein FtsQ; Region: FtsQ; pfam03799
439851000521	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
439851000522	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851000523	Cell division protein FtsA; Region: FtsA; pfam14450
439851000524	cell division protein FtsZ; Validated; Region: PRK09330
439851000525	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
439851000526	nucleotide binding site [chemical binding]; other site
439851000527	SulA interaction site; other site
439851000528	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
439851000529	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
439851000530	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
439851000531	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
439851000532	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
439851000533	SEC-C motif; Region: SEC-C; pfam02810
439851000534	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
439851000535	active site
439851000536	8-oxo-dGMP binding site [chemical binding]; other site
439851000537	nudix motif; other site
439851000538	metal binding site [ion binding]; metal-binding site
439851000539	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851000540	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851000541	active site
439851000542	catalytic tetrad [active]
439851000543	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851000544	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851000545	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
439851000546	putative effector binding pocket; other site
439851000547	putative dimerization interface [polypeptide binding]; other site
439851000548	DNA gyrase inhibitor; Reviewed; Region: PRK00418
439851000549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
439851000550	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
439851000551	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
439851000552	CoA-binding site [chemical binding]; other site
439851000553	ATP-binding [chemical binding]; other site
439851000554	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
439851000555	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
439851000556	active site
439851000557	type IV pilin biogenesis protein; Provisional; Region: PRK10573
439851000558	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
439851000559	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
439851000560	hypothetical protein; Provisional; Region: PRK10436
439851000561	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
439851000562	Walker A motif; other site
439851000563	ATP binding site [chemical binding]; other site
439851000564	Walker B motif; other site
439851000565	putative major pilin subunit; Provisional; Region: PRK10574
439851000566	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
439851000567	Pilin (bacterial filament); Region: Pilin; pfam00114
439851000568	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
439851000569	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
439851000570	dimerization interface [polypeptide binding]; other site
439851000571	active site
439851000572	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
439851000573	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
439851000574	amidase catalytic site [active]
439851000575	Zn binding residues [ion binding]; other site
439851000576	substrate binding site [chemical binding]; other site
439851000577	regulatory protein AmpE; Provisional; Region: PRK10987
439851000578	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
439851000579	active site
439851000580	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
439851000581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851000582	putative substrate translocation pore; other site
439851000583	aromatic amino acid transporter; Provisional; Region: PRK10238
439851000584	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
439851000585	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851000586	DNA-binding site [nucleotide binding]; DNA binding site
439851000587	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439851000588	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
439851000589	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
439851000590	dimer interface [polypeptide binding]; other site
439851000591	TPP-binding site [chemical binding]; other site
439851000592	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
439851000593	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439851000594	E3 interaction surface; other site
439851000595	lipoyl attachment site [posttranslational modification]; other site
439851000596	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439851000597	E3 interaction surface; other site
439851000598	lipoyl attachment site [posttranslational modification]; other site
439851000599	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439851000600	E3 interaction surface; other site
439851000601	lipoyl attachment site [posttranslational modification]; other site
439851000602	e3 binding domain; Region: E3_binding; pfam02817
439851000603	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
439851000604	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
439851000605	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851000606	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851000607	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439851000608	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
439851000609	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
439851000610	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
439851000611	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
439851000612	substrate binding site [chemical binding]; other site
439851000613	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
439851000614	substrate binding site [chemical binding]; other site
439851000615	ligand binding site [chemical binding]; other site
439851000616	putative inner membrane protein; Provisional; Region: PRK09823
439851000617	Low molecular weight phosphatase family; Region: LMWPc; cl00105
439851000618	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
439851000619	active site
439851000620	hypothetical protein; Provisional; Region: PRK05248
439851000621	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
439851000622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
439851000623	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
439851000624	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
439851000625	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851000626	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851000627	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851000628	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
439851000629	spermidine synthase; Provisional; Region: PRK00811
439851000630	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851000631	S-adenosylmethionine binding site [chemical binding]; other site
439851000632	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
439851000633	multicopper oxidase; Provisional; Region: PRK10965
439851000634	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
439851000635	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
439851000636	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
439851000637	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
439851000638	Trp docking motif [polypeptide binding]; other site
439851000639	putative active site [active]
439851000640	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
439851000641	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851000642	active site
439851000643	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
439851000644	active site clefts [active]
439851000645	zinc binding site [ion binding]; other site
439851000646	dimer interface [polypeptide binding]; other site
439851000647	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
439851000648	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439851000649	Walker A/P-loop; other site
439851000650	ATP binding site [chemical binding]; other site
439851000651	Q-loop/lid; other site
439851000652	ABC transporter signature motif; other site
439851000653	Walker B; other site
439851000654	D-loop; other site
439851000655	H-loop/switch region; other site
439851000656	inner membrane transport permease; Provisional; Region: PRK15066
439851000657	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439851000658	putative fimbrial protein StiH; Provisional; Region: PRK15297
439851000659	fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298
439851000660	PapC N-terminal domain; Region: PapC_N; pfam13954
439851000661	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851000662	PapC C-terminal domain; Region: PapC_C; pfam13953
439851000663	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
439851000664	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851000665	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851000666	fimbrial protein StiA; Provisional; Region: PRK15300
439851000667	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439851000668	active pocket/dimerization site; other site
439851000669	active site
439851000670	phosphorylation site [posttranslational modification]
439851000671	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
439851000672	putative active site [active]
439851000673	putative metal binding site [ion binding]; other site
439851000674	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
439851000675	tetramerization interface [polypeptide binding]; other site
439851000676	active site
439851000677	Pantoate-beta-alanine ligase; Region: PanC; cd00560
439851000678	pantoate--beta-alanine ligase; Region: panC; TIGR00018
439851000679	active site
439851000680	ATP-binding site [chemical binding]; other site
439851000681	pantoate-binding site; other site
439851000682	HXXH motif; other site
439851000683	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
439851000684	oligomerization interface [polypeptide binding]; other site
439851000685	active site
439851000686	metal binding site [ion binding]; metal-binding site
439851000687	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
439851000688	catalytic center binding site [active]
439851000689	ATP binding site [chemical binding]; other site
439851000690	poly(A) polymerase; Region: pcnB; TIGR01942
439851000691	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
439851000692	active site
439851000693	NTP binding site [chemical binding]; other site
439851000694	metal binding triad [ion binding]; metal-binding site
439851000695	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
439851000696	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
439851000697	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
439851000698	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
439851000699	active site
439851000700	nucleotide binding site [chemical binding]; other site
439851000701	HIGH motif; other site
439851000702	KMSKS motif; other site
439851000703	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
439851000704	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
439851000705	2'-5' RNA ligase; Provisional; Region: PRK15124
439851000706	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
439851000707	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
439851000708	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
439851000709	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851000710	ATP binding site [chemical binding]; other site
439851000711	putative Mg++ binding site [ion binding]; other site
439851000712	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851000713	nucleotide binding region [chemical binding]; other site
439851000714	ATP-binding site [chemical binding]; other site
439851000715	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
439851000716	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
439851000717	Transglycosylase; Region: Transgly; pfam00912
439851000718	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
439851000719	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
439851000720	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851000721	N-terminal plug; other site
439851000722	ligand-binding site [chemical binding]; other site
439851000723	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
439851000724	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439851000725	Walker A/P-loop; other site
439851000726	ATP binding site [chemical binding]; other site
439851000727	Q-loop/lid; other site
439851000728	ABC transporter signature motif; other site
439851000729	Walker B; other site
439851000730	D-loop; other site
439851000731	H-loop/switch region; other site
439851000732	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
439851000733	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
439851000734	siderophore binding site; other site
439851000735	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439851000736	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851000737	ABC-ATPase subunit  interface; other site
439851000738	dimer interface [polypeptide binding]; other site
439851000739	putative PBP binding regions; other site
439851000740	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851000741	ABC-ATPase subunit  interface; other site
439851000742	dimer interface [polypeptide binding]; other site
439851000743	putative PBP binding regions; other site
439851000744	putative fimbrial subunit StfA; Provisional; Region: PRK15283
439851000745	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
439851000746	PapC N-terminal domain; Region: PapC_N; pfam13954
439851000747	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851000748	PapC C-terminal domain; Region: PapC_C; pfam13953
439851000749	putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285
439851000750	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851000751	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851000752	putative minor fimbrial subunit StfE; Provisional; Region: PRK15286
439851000753	putative minor fimbrial subunit StfF; Provisional; Region: PRK15287
439851000754	putative minor fimbrial subunit StfG; Provisional; Region: PRK15288
439851000755	Protein of unknown function (DUF2544); Region: DUF2544; pfam11245
439851000756	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
439851000757	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439851000758	inhibitor-cofactor binding pocket; inhibition site
439851000759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851000760	catalytic residue [active]
439851000761	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
439851000762	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
439851000763	Cl- selectivity filter; other site
439851000764	Cl- binding residues [ion binding]; other site
439851000765	pore gating glutamate residue; other site
439851000766	dimer interface [polypeptide binding]; other site
439851000767	H+/Cl- coupling transport residue; other site
439851000768	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
439851000769	hypothetical protein; Provisional; Region: PRK10578
439851000770	UPF0126 domain; Region: UPF0126; pfam03458
439851000771	UPF0126 domain; Region: UPF0126; pfam03458
439851000772	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
439851000773	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
439851000774	cobalamin binding residues [chemical binding]; other site
439851000775	putative BtuC binding residues; other site
439851000776	dimer interface [polypeptide binding]; other site
439851000777	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
439851000778	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
439851000779	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
439851000780	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439851000781	Zn2+ binding site [ion binding]; other site
439851000782	Mg2+ binding site [ion binding]; other site
439851000783	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
439851000784	serine endoprotease; Provisional; Region: PRK10942
439851000785	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
439851000786	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439851000787	protein binding site [polypeptide binding]; other site
439851000788	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439851000789	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
439851000790	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
439851000791	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
439851000792	Viral enhancin protein; Region: Enhancin; pfam03272
439851000793	Peptidase M60-like family; Region: M60-like; pfam13402
439851000794	hypothetical protein; Provisional; Region: PRK13677
439851000795	shikimate transporter; Provisional; Region: PRK09952
439851000796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851000797	putative substrate translocation pore; other site
439851000798	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
439851000799	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
439851000800	trimer interface [polypeptide binding]; other site
439851000801	active site
439851000802	substrate binding site [chemical binding]; other site
439851000803	CoA binding site [chemical binding]; other site
439851000804	PII uridylyl-transferase; Provisional; Region: PRK05007
439851000805	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
439851000806	metal binding triad; other site
439851000807	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
439851000808	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439851000809	Zn2+ binding site [ion binding]; other site
439851000810	Mg2+ binding site [ion binding]; other site
439851000811	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
439851000812	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
439851000813	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
439851000814	active site
439851000815	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
439851000816	rRNA interaction site [nucleotide binding]; other site
439851000817	S8 interaction site; other site
439851000818	putative laminin-1 binding site; other site
439851000819	elongation factor Ts; Provisional; Region: tsf; PRK09377
439851000820	UBA/TS-N domain; Region: UBA; pfam00627
439851000821	Elongation factor TS; Region: EF_TS; pfam00889
439851000822	Elongation factor TS; Region: EF_TS; pfam00889
439851000823	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
439851000824	putative nucleotide binding site [chemical binding]; other site
439851000825	uridine monophosphate binding site [chemical binding]; other site
439851000826	homohexameric interface [polypeptide binding]; other site
439851000827	ribosome recycling factor; Reviewed; Region: frr; PRK00083
439851000828	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
439851000829	hinge region; other site
439851000830	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
439851000831	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
439851000832	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
439851000833	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
439851000834	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
439851000835	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
439851000836	catalytic residue [active]
439851000837	putative FPP diphosphate  binding site; other site
439851000838	putative FPP binding hydrophobic cleft; other site
439851000839	dimer interface [polypeptide binding]; other site
439851000840	putative IPP diphosphate binding site; other site
439851000841	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
439851000842	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
439851000843	zinc metallopeptidase RseP; Provisional; Region: PRK10779
439851000844	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
439851000845	active site
439851000846	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
439851000847	protein binding site [polypeptide binding]; other site
439851000848	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
439851000849	protein binding site [polypeptide binding]; other site
439851000850	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
439851000851	putative substrate binding region [chemical binding]; other site
439851000852	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
439851000853	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439851000854	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439851000855	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439851000856	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439851000857	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439851000858	Surface antigen; Region: Bac_surface_Ag; pfam01103
439851000859	periplasmic chaperone; Provisional; Region: PRK10780
439851000860	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
439851000861	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
439851000862	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
439851000863	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
439851000864	trimer interface [polypeptide binding]; other site
439851000865	active site
439851000866	UDP-GlcNAc binding site [chemical binding]; other site
439851000867	lipid binding site [chemical binding]; lipid-binding site
439851000868	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
439851000869	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
439851000870	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
439851000871	active site
439851000872	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
439851000873	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
439851000874	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
439851000875	RNA/DNA hybrid binding site [nucleotide binding]; other site
439851000876	active site
439851000877	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
439851000878	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
439851000879	putative active site [active]
439851000880	putative PHP Thumb interface [polypeptide binding]; other site
439851000881	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
439851000882	generic binding surface II; other site
439851000883	generic binding surface I; other site
439851000884	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
439851000885	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
439851000886	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
439851000887	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
439851000888	putative sugar binding site [chemical binding]; other site
439851000889	catalytic residues [active]
439851000890	PKD domain; Region: PKD; pfam00801
439851000891	lysine decarboxylase LdcC; Provisional; Region: PRK15399
439851000892	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439851000893	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439851000894	homodimer interface [polypeptide binding]; other site
439851000895	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851000896	catalytic residue [active]
439851000897	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439851000898	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
439851000899	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
439851000900	putative metal binding site [ion binding]; other site
439851000901	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
439851000902	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
439851000903	Ligand Binding Site [chemical binding]; other site
439851000904	TilS substrate binding domain; Region: TilS; pfam09179
439851000905	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
439851000906	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210
439851000907	hypothetical protein; Provisional; Region: PRK04964
439851000908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
439851000909	hypothetical protein; Provisional; Region: PRK09256
439851000910	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
439851000911	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
439851000912	NlpE N-terminal domain; Region: NlpE; pfam04170
439851000913	prolyl-tRNA synthetase; Provisional; Region: PRK09194
439851000914	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
439851000915	dimer interface [polypeptide binding]; other site
439851000916	motif 1; other site
439851000917	active site
439851000918	motif 2; other site
439851000919	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
439851000920	putative deacylase active site [active]
439851000921	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
439851000922	active site
439851000923	motif 3; other site
439851000924	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
439851000925	anticodon binding site; other site
439851000926	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
439851000927	homodimer interaction site [polypeptide binding]; other site
439851000928	cofactor binding site; other site
439851000929	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
439851000930	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
439851000931	lipoprotein, YaeC family; Region: TIGR00363
439851000932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851000933	dimer interface [polypeptide binding]; other site
439851000934	conserved gate region; other site
439851000935	ABC-ATPase subunit interface; other site
439851000936	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
439851000937	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
439851000938	Walker A/P-loop; other site
439851000939	ATP binding site [chemical binding]; other site
439851000940	Q-loop/lid; other site
439851000941	ABC transporter signature motif; other site
439851000942	Walker B; other site
439851000943	D-loop; other site
439851000944	H-loop/switch region; other site
439851000945	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
439851000946	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
439851000947	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851000948	active site
439851000949	motif I; other site
439851000950	motif II; other site
439851000951	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851000952	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851000953	active site
439851000954	catalytic tetrad [active]
439851000955	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851000956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851000957	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
439851000958	putative effector binding pocket; other site
439851000959	dimerization interface [polypeptide binding]; other site
439851000960	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
439851000961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851000962	putative substrate translocation pore; other site
439851000963	hypothetical protein; Provisional; Region: PRK05421
439851000964	putative catalytic site [active]
439851000965	putative metal binding site [ion binding]; other site
439851000966	putative phosphate binding site [ion binding]; other site
439851000967	putative catalytic site [active]
439851000968	putative phosphate binding site [ion binding]; other site
439851000969	putative metal binding site [ion binding]; other site
439851000970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851000971	S-adenosylmethionine binding site [chemical binding]; other site
439851000972	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
439851000973	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439851000974	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851000975	catalytic residue [active]
439851000976	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
439851000977	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851000978	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
439851000979	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851000980	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
439851000981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851000982	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
439851000983	RNA/DNA hybrid binding site [nucleotide binding]; other site
439851000984	active site
439851000985	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
439851000986	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
439851000987	active site
439851000988	catalytic site [active]
439851000989	substrate binding site [chemical binding]; other site
439851000990	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
439851000991	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
439851000992	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
439851000993	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
439851000994	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
439851000995	ImpE protein; Region: ImpE; pfam07024
439851000996	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
439851000997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851000998	Walker A motif; other site
439851000999	ATP binding site [chemical binding]; other site
439851001000	Walker B motif; other site
439851001001	arginine finger; other site
439851001002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851001003	Walker A motif; other site
439851001004	ATP binding site [chemical binding]; other site
439851001005	Walker B motif; other site
439851001006	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
439851001007	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
439851001008	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
439851001009	Protein of unknown function (DUF877); Region: DUF877; pfam05943
439851001010	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
439851001011	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
439851001012	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
439851001013	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
439851001014	hypothetical protein; Provisional; Region: PRK08126
439851001015	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
439851001016	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439851001017	ligand binding site [chemical binding]; other site
439851001018	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
439851001019	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
439851001020	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
439851001021	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
439851001022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
439851001023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
439851001024	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
439851001025	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
439851001026	Uncharacterized conserved protein [Function unknown]; Region: COG5435
439851001027	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
439851001028	RHS Repeat; Region: RHS_repeat; cl11982
439851001029	RHS Repeat; Region: RHS_repeat; cl11982
439851001030	RHS Repeat; Region: RHS_repeat; pfam05593
439851001031	RHS Repeat; Region: RHS_repeat; cl11982
439851001032	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
439851001033	RHS Repeat; Region: RHS_repeat; pfam05593
439851001034	RHS Repeat; Region: RHS_repeat; pfam05593
439851001035	RHS Repeat; Region: RHS_repeat; pfam05593
439851001036	RHS Repeat; Region: RHS_repeat; pfam05593
439851001037	RHS Repeat; Region: RHS_repeat; pfam05593
439851001038	RHS protein; Region: RHS; pfam03527
439851001039	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
439851001040	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
439851001041	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
439851001042	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
439851001043	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
439851001044	PapC N-terminal domain; Region: PapC_N; pfam13954
439851001045	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851001046	PapC C-terminal domain; Region: PapC_C; pfam13953
439851001047	putative pilin structural protein SafD; Provisional; Region: PRK15222
439851001048	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
439851001049	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
439851001050	putative active site [active]
439851001051	putative metal binding site [ion binding]; other site
439851001052	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851001053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851001054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851001055	dimerization interface [polypeptide binding]; other site
439851001056	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
439851001057	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439851001058	dimer interface [polypeptide binding]; other site
439851001059	C-N hydrolase family amidase; Provisional; Region: PRK10438
439851001060	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
439851001061	putative active site [active]
439851001062	catalytic triad [active]
439851001063	dimer interface [polypeptide binding]; other site
439851001064	multimer interface [polypeptide binding]; other site
439851001065	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
439851001066	dimer interface [polypeptide binding]; other site
439851001067	active site
439851001068	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
439851001069	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
439851001070	putative active site [active]
439851001071	putative dimer interface [polypeptide binding]; other site
439851001072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
439851001073	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439851001074	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
439851001075	active site
439851001076	DNA polymerase IV; Validated; Region: PRK02406
439851001077	DNA binding site [nucleotide binding]
439851001078	hypothetical protein; Reviewed; Region: PRK09588
439851001079	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
439851001080	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
439851001081	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
439851001082	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
439851001083	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
439851001084	metal binding site [ion binding]; metal-binding site
439851001085	dimer interface [polypeptide binding]; other site
439851001086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851001087	active site
439851001088	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
439851001089	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
439851001090	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851001091	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439851001092	trimer interface [polypeptide binding]; other site
439851001093	eyelet of channel; other site
439851001094	gamma-glutamyl kinase; Provisional; Region: PRK05429
439851001095	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
439851001096	nucleotide binding site [chemical binding]; other site
439851001097	homotetrameric interface [polypeptide binding]; other site
439851001098	putative phosphate binding site [ion binding]; other site
439851001099	putative allosteric binding site; other site
439851001100	PUA domain; Region: PUA; pfam01472
439851001101	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
439851001102	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
439851001103	putative catalytic cysteine [active]
439851001104	HTH-like domain; Region: HTH_21; pfam13276
439851001105	Transposase; Region: HTH_Tnp_1; cl17663
439851001106	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
439851001107	Domain of unknown function (DUF1889); Region: DUF1889; pfam08986
439851001108	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
439851001109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001110	putative substrate translocation pore; other site
439851001111	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
439851001112	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
439851001113	substrate binding site [chemical binding]; other site
439851001114	ligand binding site [chemical binding]; other site
439851001115	3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066
439851001116	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
439851001117	hypothetical protein; Provisional; Region: PRK14812
439851001118	substrate binding site [chemical binding]; other site
439851001119	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
439851001120	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
439851001121	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
439851001122	transcriptional activator TtdR; Provisional; Region: PRK09801
439851001123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851001124	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
439851001125	putative effector binding pocket; other site
439851001126	putative dimerization interface [polypeptide binding]; other site
439851001127	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
439851001128	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851001129	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851001130	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
439851001131	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
439851001132	PapC N-terminal domain; Region: PapC_N; pfam13954
439851001133	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851001134	PapC C-terminal domain; Region: PapC_C; pfam13953
439851001135	fimbrial chaperone protein StbB; Provisional; Region: PRK15249
439851001136	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851001137	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851001138	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439851001139	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439851001140	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851001141	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
439851001142	DNA binding site [nucleotide binding]
439851001143	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
439851001144	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
439851001145	DNA binding residues [nucleotide binding]
439851001146	dimerization interface [polypeptide binding]; other site
439851001147	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
439851001148	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
439851001149	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
439851001150	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
439851001151	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851001152	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851001153	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
439851001154	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439851001155	metal-binding site [ion binding]
439851001156	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439851001157	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851001158	motif II; other site
439851001159	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
439851001160	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
439851001161	DNA binding residues [nucleotide binding]
439851001162	dimer interface [polypeptide binding]; other site
439851001163	copper binding site [ion binding]; other site
439851001164	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439851001165	metal-binding site [ion binding]
439851001166	putative sialic acid transporter; Region: 2A0112; TIGR00891
439851001167	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001168	putative substrate translocation pore; other site
439851001169	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
439851001170	DNA methylase; Region: N6_N4_Mtase; cl17433
439851001171	DNA methylase; Region: N6_N4_Mtase; pfam01555
439851001172	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
439851001173	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
439851001174	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
439851001175	VRR-NUC domain; Region: VRR_NUC; pfam08774
439851001176	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
439851001177	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
439851001178	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
439851001179	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
439851001180	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851001181	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
439851001182	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851001183	N-terminal plug; other site
439851001184	ligand-binding site [chemical binding]; other site
439851001185	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
439851001186	hypothetical protein; Provisional; Region: PRK09929
439851001187	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
439851001188	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
439851001189	tetramer interface [polypeptide binding]; other site
439851001190	active site
439851001191	Mg2+/Mn2+ binding site [ion binding]; other site
439851001192	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
439851001193	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
439851001194	dimer interface [polypeptide binding]; other site
439851001195	active site
439851001196	citrylCoA binding site [chemical binding]; other site
439851001197	oxalacetate/citrate binding site [chemical binding]; other site
439851001198	coenzyme A binding site [chemical binding]; other site
439851001199	catalytic triad [active]
439851001200	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
439851001201	2-methylcitrate dehydratase; Region: prpD; TIGR02330
439851001202	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
439851001203	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
439851001204	acyl-activating enzyme (AAE) consensus motif; other site
439851001205	AMP binding site [chemical binding]; other site
439851001206	active site
439851001207	CoA binding site [chemical binding]; other site
439851001208	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
439851001209	dimer interface [polypeptide binding]; other site
439851001210	active site
439851001211	Schiff base residues; other site
439851001212	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
439851001213	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
439851001214	Autotransporter beta-domain; Region: Autotransporter; pfam03797
439851001215	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
439851001216	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
439851001217	microcin B17 transporter; Reviewed; Region: PRK11098
439851001218	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
439851001219	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
439851001220	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
439851001221	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
439851001222	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
439851001223	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
439851001224	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
439851001225	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
439851001226	anti-RssB factor; Provisional; Region: PRK10244
439851001227	hypothetical protein; Provisional; Region: PRK11505
439851001228	psiF repeat; Region: PsiF_repeat; pfam07769
439851001229	psiF repeat; Region: PsiF_repeat; pfam07769
439851001230	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
439851001231	MASE2 domain; Region: MASE2; pfam05230
439851001232	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851001233	metal binding site [ion binding]; metal-binding site
439851001234	active site
439851001235	I-site; other site
439851001236	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
439851001237	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
439851001238	hypothetical protein; Validated; Region: PRK00124
439851001239	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
439851001240	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
439851001241	ADP binding site [chemical binding]; other site
439851001242	magnesium binding site [ion binding]; other site
439851001243	putative shikimate binding site; other site
439851001244	hypothetical protein; Provisional; Region: PRK10380
439851001245	hypothetical protein; Provisional; Region: PRK10481
439851001246	hypothetical protein; Provisional; Region: PRK10579
439851001247	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
439851001248	fructokinase; Reviewed; Region: PRK09557
439851001249	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851001250	nucleotide binding site [chemical binding]; other site
439851001251	MFS transport protein AraJ; Provisional; Region: PRK10091
439851001252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001253	putative substrate translocation pore; other site
439851001254	exonuclease subunit SbcC; Provisional; Region: PRK10246
439851001255	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851001256	Walker A/P-loop; other site
439851001257	ATP binding site [chemical binding]; other site
439851001258	Q-loop/lid; other site
439851001259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851001260	ABC transporter signature motif; other site
439851001261	Walker B; other site
439851001262	D-loop; other site
439851001263	H-loop/switch region; other site
439851001264	exonuclease subunit SbcD; Provisional; Region: PRK10966
439851001265	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
439851001266	active site
439851001267	metal binding site [ion binding]; metal-binding site
439851001268	DNA binding site [nucleotide binding]
439851001269	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
439851001270	transcriptional regulator PhoB; Provisional; Region: PRK10161
439851001271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851001272	active site
439851001273	phosphorylation site [posttranslational modification]
439851001274	intermolecular recognition site; other site
439851001275	dimerization interface [polypeptide binding]; other site
439851001276	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851001277	DNA binding site [nucleotide binding]
439851001278	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
439851001279	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
439851001280	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439851001281	putative active site [active]
439851001282	heme pocket [chemical binding]; other site
439851001283	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851001284	dimer interface [polypeptide binding]; other site
439851001285	phosphorylation site [posttranslational modification]
439851001286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851001287	ATP binding site [chemical binding]; other site
439851001288	Mg2+ binding site [ion binding]; other site
439851001289	G-X-G motif; other site
439851001290	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
439851001291	putative proline-specific permease; Provisional; Region: proY; PRK10580
439851001292	peroxidase; Provisional; Region: PRK15000
439851001293	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
439851001294	dimer interface [polypeptide binding]; other site
439851001295	decamer (pentamer of dimers) interface [polypeptide binding]; other site
439851001296	catalytic triad [active]
439851001297	peroxidatic and resolving cysteines [active]
439851001298	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
439851001299	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
439851001300	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
439851001301	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
439851001302	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
439851001303	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
439851001304	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
439851001305	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
439851001306	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
439851001307	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
439851001308	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
439851001309	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
439851001310	Protein export membrane protein; Region: SecD_SecF; pfam02355
439851001311	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
439851001312	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
439851001313	Predicted transcriptional regulator [Transcription]; Region: COG2378
439851001314	HTH domain; Region: HTH_11; pfam08279
439851001315	WYL domain; Region: WYL; pfam13280
439851001316	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
439851001317	active site
439851001318	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
439851001319	hypothetical protein; Provisional; Region: PRK11530
439851001320	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
439851001321	ATP cone domain; Region: ATP-cone; pfam03477
439851001322	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
439851001323	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
439851001324	catalytic motif [active]
439851001325	Zn binding site [ion binding]; other site
439851001326	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
439851001327	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
439851001328	homopentamer interface [polypeptide binding]; other site
439851001329	active site
439851001330	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
439851001331	putative RNA binding site [nucleotide binding]; other site
439851001332	thiamine monophosphate kinase; Provisional; Region: PRK05731
439851001333	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
439851001334	ATP binding site [chemical binding]; other site
439851001335	dimerization interface [polypeptide binding]; other site
439851001336	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
439851001337	tetramer interfaces [polypeptide binding]; other site
439851001338	binuclear metal-binding site [ion binding]; other site
439851001339	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851001340	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851001341	active site
439851001342	catalytic tetrad [active]
439851001343	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
439851001344	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
439851001345	TPP-binding site; other site
439851001346	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439851001347	PYR/PP interface [polypeptide binding]; other site
439851001348	dimer interface [polypeptide binding]; other site
439851001349	TPP binding site [chemical binding]; other site
439851001350	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439851001351	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
439851001352	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
439851001353	substrate binding pocket [chemical binding]; other site
439851001354	chain length determination region; other site
439851001355	substrate-Mg2+ binding site; other site
439851001356	catalytic residues [active]
439851001357	aspartate-rich region 1; other site
439851001358	active site lid residues [active]
439851001359	aspartate-rich region 2; other site
439851001360	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
439851001361	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
439851001362	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
439851001363	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
439851001364	Ligand Binding Site [chemical binding]; other site
439851001365	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
439851001366	active site residue [active]
439851001367	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
439851001368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851001369	dimer interface [polypeptide binding]; other site
439851001370	conserved gate region; other site
439851001371	putative PBP binding loops; other site
439851001372	ABC-ATPase subunit interface; other site
439851001373	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
439851001374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851001375	dimer interface [polypeptide binding]; other site
439851001376	conserved gate region; other site
439851001377	putative PBP binding loops; other site
439851001378	ABC-ATPase subunit interface; other site
439851001379	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
439851001380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851001381	Walker A/P-loop; other site
439851001382	ATP binding site [chemical binding]; other site
439851001383	Q-loop/lid; other site
439851001384	ABC transporter signature motif; other site
439851001385	Walker B; other site
439851001386	D-loop; other site
439851001387	H-loop/switch region; other site
439851001388	TOBE domain; Region: TOBE_2; pfam08402
439851001389	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
439851001390	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
439851001391	transcriptional regulator protein; Region: phnR; TIGR03337
439851001392	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851001393	DNA-binding site [nucleotide binding]; DNA binding site
439851001394	UTRA domain; Region: UTRA; pfam07702
439851001395	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
439851001396	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851001397	catalytic residue [active]
439851001398	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
439851001399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851001400	motif II; other site
439851001401	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
439851001402	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
439851001403	conserved cys residue [active]
439851001404	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
439851001405	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
439851001406	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
439851001407	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
439851001408	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
439851001409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001410	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851001411	putative substrate translocation pore; other site
439851001412	Sel1-like repeats; Region: SEL1; smart00671
439851001413	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851001414	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851001415	Sel1 repeat; Region: Sel1; pfam08238
439851001416	Sel1-like repeats; Region: SEL1; smart00671
439851001417	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851001418	Sel1-like repeats; Region: SEL1; smart00671
439851001419	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851001420	Sel1-like repeats; Region: SEL1; smart00671
439851001421	Sel1-like repeats; Region: SEL1; smart00671
439851001422	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
439851001423	UbiA prenyltransferase family; Region: UbiA; pfam01040
439851001424	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
439851001425	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
439851001426	Subunit I/III interface [polypeptide binding]; other site
439851001427	Subunit III/IV interface [polypeptide binding]; other site
439851001428	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
439851001429	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
439851001430	D-pathway; other site
439851001431	Putative ubiquinol binding site [chemical binding]; other site
439851001432	Low-spin heme (heme b) binding site [chemical binding]; other site
439851001433	Putative water exit pathway; other site
439851001434	Binuclear center (heme o3/CuB) [ion binding]; other site
439851001435	K-pathway; other site
439851001436	Putative proton exit pathway; other site
439851001437	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
439851001438	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
439851001439	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
439851001440	muropeptide transporter; Reviewed; Region: ampG; PRK11902
439851001441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001442	putative substrate translocation pore; other site
439851001443	transcriptional regulator BolA; Provisional; Region: PRK11628
439851001444	trigger factor; Provisional; Region: tig; PRK01490
439851001445	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439851001446	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
439851001447	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
439851001448	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
439851001449	oligomer interface [polypeptide binding]; other site
439851001450	active site residues [active]
439851001451	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
439851001452	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
439851001453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851001454	Walker A motif; other site
439851001455	ATP binding site [chemical binding]; other site
439851001456	Walker B motif; other site
439851001457	Iron permease FTR1 family; Region: FTR1; cl00475
439851001458	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
439851001459	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
439851001460	Found in ATP-dependent protease La (LON); Region: LON; smart00464
439851001461	Found in ATP-dependent protease La (LON); Region: LON; smart00464
439851001462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851001463	Walker A motif; other site
439851001464	ATP binding site [chemical binding]; other site
439851001465	Walker B motif; other site
439851001466	arginine finger; other site
439851001467	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
439851001468	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439851001469	IHF dimer interface [polypeptide binding]; other site
439851001470	IHF - DNA interface [nucleotide binding]; other site
439851001471	periplasmic folding chaperone; Provisional; Region: PRK10788
439851001472	SurA N-terminal domain; Region: SurA_N_3; cl07813
439851001473	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
439851001474	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
439851001475	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
439851001476	active site
439851001477	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
439851001478	Ligand Binding Site [chemical binding]; other site
439851001479	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
439851001480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851001481	active site
439851001482	motif I; other site
439851001483	motif II; other site
439851001484	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
439851001485	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
439851001486	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851001487	catalytic residue [active]
439851001488	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
439851001489	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439851001490	putative DNA binding site [nucleotide binding]; other site
439851001491	putative Zn2+ binding site [ion binding]; other site
439851001492	AsnC family; Region: AsnC_trans_reg; pfam01037
439851001493	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
439851001494	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439851001495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851001496	Walker A/P-loop; other site
439851001497	ATP binding site [chemical binding]; other site
439851001498	Q-loop/lid; other site
439851001499	ABC transporter signature motif; other site
439851001500	Walker B; other site
439851001501	D-loop; other site
439851001502	H-loop/switch region; other site
439851001503	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
439851001504	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439851001505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851001506	Walker A/P-loop; other site
439851001507	ATP binding site [chemical binding]; other site
439851001508	Q-loop/lid; other site
439851001509	ABC transporter signature motif; other site
439851001510	Walker B; other site
439851001511	D-loop; other site
439851001512	H-loop/switch region; other site
439851001513	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
439851001514	Nitrogen regulatory protein P-II; Region: P-II; smart00938
439851001515	ammonium transporter; Provisional; Region: PRK10666
439851001516	acyl-CoA thioesterase II; Provisional; Region: PRK10526
439851001517	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
439851001518	active site
439851001519	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
439851001520	catalytic triad [active]
439851001521	dimer interface [polypeptide binding]; other site
439851001522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
439851001523	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
439851001524	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
439851001525	DNA binding site [nucleotide binding]
439851001526	active site
439851001527	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
439851001528	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439851001529	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851001530	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
439851001531	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
439851001532	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
439851001533	maltose O-acetyltransferase; Provisional; Region: PRK10092
439851001534	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
439851001535	active site
439851001536	substrate binding site [chemical binding]; other site
439851001537	trimer interface [polypeptide binding]; other site
439851001538	CoA binding site [chemical binding]; other site
439851001539	gene expression modulator; Provisional; Region: PRK10945
439851001540	Hha toxicity attenuator; Provisional; Region: PRK10667
439851001541	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
439851001542	Protein export membrane protein; Region: SecD_SecF; cl14618
439851001543	Protein export membrane protein; Region: SecD_SecF; cl14618
439851001544	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
439851001545	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851001546	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
439851001547	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851001548	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
439851001549	hypothetical protein; Provisional; Region: PRK11281
439851001550	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
439851001551	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
439851001552	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851001553	Uncharacterized conserved protein [Function unknown]; Region: COG5464
439851001554	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
439851001555	hypothetical protein; Provisional; Region: PRK11038
439851001556	primosomal replication protein N''; Provisional; Region: PRK10093
439851001557	hypothetical protein; Provisional; Region: PRK10527
439851001558	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851001559	active site
439851001560	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
439851001561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851001562	Walker A motif; other site
439851001563	ATP binding site [chemical binding]; other site
439851001564	Walker B motif; other site
439851001565	DNA polymerase III subunit delta'; Validated; Region: PRK08485
439851001566	arginine finger; other site
439851001567	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
439851001568	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
439851001569	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
439851001570	DnaX ribosomal frameshifting element
439851001571	hypothetical protein; Validated; Region: PRK00153
439851001572	recombination protein RecR; Reviewed; Region: recR; PRK00076
439851001573	RecR protein; Region: RecR; pfam02132
439851001574	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
439851001575	putative active site [active]
439851001576	putative metal-binding site [ion binding]; other site
439851001577	tetramer interface [polypeptide binding]; other site
439851001578	heat shock protein 90; Provisional; Region: PRK05218
439851001579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851001580	ATP binding site [chemical binding]; other site
439851001581	Mg2+ binding site [ion binding]; other site
439851001582	G-X-G motif; other site
439851001583	adenylate kinase; Reviewed; Region: adk; PRK00279
439851001584	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
439851001585	AMP-binding site [chemical binding]; other site
439851001586	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
439851001587	ferrochelatase; Reviewed; Region: hemH; PRK00035
439851001588	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
439851001589	C-terminal domain interface [polypeptide binding]; other site
439851001590	active site
439851001591	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
439851001592	active site
439851001593	N-terminal domain interface [polypeptide binding]; other site
439851001594	acetyl esterase; Provisional; Region: PRK10162
439851001595	inosine/guanosine kinase; Provisional; Region: PRK15074
439851001596	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851001597	putative cation:proton antiport protein; Provisional; Region: PRK10669
439851001598	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
439851001599	TrkA-N domain; Region: TrkA_N; pfam02254
439851001600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001601	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851001602	putative substrate translocation pore; other site
439851001603	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
439851001604	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
439851001605	active site
439851001606	metal binding site [ion binding]; metal-binding site
439851001607	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439851001608	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
439851001609	putative deacylase active site [active]
439851001610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
439851001611	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
439851001612	copper exporting ATPase; Provisional; Region: copA; PRK10671
439851001613	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439851001614	metal-binding site [ion binding]
439851001615	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439851001616	metal-binding site [ion binding]
439851001617	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439851001618	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851001619	motif II; other site
439851001620	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
439851001621	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
439851001622	DNA binding residues [nucleotide binding]
439851001623	dimer interface [polypeptide binding]; other site
439851001624	copper binding site [ion binding]; other site
439851001625	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
439851001626	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
439851001627	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
439851001628	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
439851001629	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
439851001630	Walker A/P-loop; other site
439851001631	ATP binding site [chemical binding]; other site
439851001632	Q-loop/lid; other site
439851001633	ABC transporter signature motif; other site
439851001634	Walker B; other site
439851001635	D-loop; other site
439851001636	H-loop/switch region; other site
439851001637	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
439851001638	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
439851001639	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
439851001640	oxidoreductase; Provisional; Region: PRK08017
439851001641	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
439851001642	NADP binding site [chemical binding]; other site
439851001643	active site
439851001644	steroid binding site; other site
439851001645	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
439851001646	active site
439851001647	catalytic triad [active]
439851001648	oxyanion hole [active]
439851001649	switch loop; other site
439851001650	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
439851001651	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
439851001652	Walker A/P-loop; other site
439851001653	ATP binding site [chemical binding]; other site
439851001654	Q-loop/lid; other site
439851001655	ABC transporter signature motif; other site
439851001656	Walker B; other site
439851001657	D-loop; other site
439851001658	H-loop/switch region; other site
439851001659	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
439851001660	FtsX-like permease family; Region: FtsX; pfam02687
439851001661	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851001662	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
439851001663	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
439851001664	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
439851001665	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
439851001666	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
439851001667	Walker A/P-loop; other site
439851001668	ATP binding site [chemical binding]; other site
439851001669	Q-loop/lid; other site
439851001670	ABC transporter signature motif; other site
439851001671	Walker B; other site
439851001672	D-loop; other site
439851001673	H-loop/switch region; other site
439851001674	NIL domain; Region: NIL; pfam09383
439851001675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851001676	dimer interface [polypeptide binding]; other site
439851001677	conserved gate region; other site
439851001678	ABC-ATPase subunit interface; other site
439851001679	Predicted ATPase [General function prediction only]; Region: COG2603
439851001680	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
439851001681	active site residue [active]
439851001682	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
439851001683	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851001684	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851001685	dimerization interface [polypeptide binding]; other site
439851001686	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
439851001687	ureidoglycolate hydrolase; Provisional; Region: PRK03606
439851001688	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
439851001689	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439851001690	Bacterial transcriptional regulator; Region: IclR; pfam01614
439851001691	glyoxylate carboligase; Provisional; Region: PRK11269
439851001692	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
439851001693	PYR/PP interface [polypeptide binding]; other site
439851001694	dimer interface [polypeptide binding]; other site
439851001695	TPP binding site [chemical binding]; other site
439851001696	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439851001697	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
439851001698	TPP-binding site [chemical binding]; other site
439851001699	hydroxypyruvate isomerase; Provisional; Region: PRK09997
439851001700	tartronate semialdehyde reductase; Provisional; Region: PRK15059
439851001701	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439851001702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001703	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851001704	putative substrate translocation pore; other site
439851001705	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
439851001706	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
439851001707	Na binding site [ion binding]; other site
439851001708	putative substrate binding site [chemical binding]; other site
439851001709	allantoinase; Provisional; Region: PRK08044
439851001710	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
439851001711	active site
439851001712	putative uracil/xanthine transporter; Provisional; Region: PRK11412
439851001713	glycerate kinase II; Provisional; Region: PRK09932
439851001714	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
439851001715	Mif2/CENP-C like; Region: Mif2; pfam11699
439851001716	Cupin domain; Region: Cupin_2; pfam07883
439851001717	allantoate amidohydrolase; Region: AllC; TIGR03176
439851001718	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
439851001719	active site
439851001720	metal binding site [ion binding]; metal-binding site
439851001721	dimer interface [polypeptide binding]; other site
439851001722	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
439851001723	membrane protein FdrA; Validated; Region: PRK06091
439851001724	CoA binding domain; Region: CoA_binding; pfam02629
439851001725	CoA-ligase; Region: Ligase_CoA; pfam00549
439851001726	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
439851001727	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
439851001728	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
439851001729	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
439851001730	putative substrate binding site [chemical binding]; other site
439851001731	nucleotide binding site [chemical binding]; other site
439851001732	nucleotide binding site [chemical binding]; other site
439851001733	homodimer interface [polypeptide binding]; other site
439851001734	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
439851001735	ATP-grasp domain; Region: ATP-grasp; pfam02222
439851001736	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
439851001737	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
439851001738	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439851001739	putative active site [active]
439851001740	putative metal binding site [ion binding]; other site
439851001741	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
439851001742	substrate binding site [chemical binding]; other site
439851001743	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
439851001744	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
439851001745	active site
439851001746	HIGH motif; other site
439851001747	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
439851001748	KMSKS motif; other site
439851001749	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
439851001750	tRNA binding surface [nucleotide binding]; other site
439851001751	anticodon binding site; other site
439851001752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
439851001753	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
439851001754	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
439851001755	ribosome-associated protein; Provisional; Region: PRK11507
439851001756	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
439851001757	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
439851001758	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
439851001759	homodimer interface [polypeptide binding]; other site
439851001760	NADP binding site [chemical binding]; other site
439851001761	substrate binding site [chemical binding]; other site
439851001762	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
439851001763	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
439851001764	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851001765	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851001766	outer membrane usher protein FimD; Provisional; Region: PRK15198
439851001767	PapC N-terminal domain; Region: PapC_N; pfam13954
439851001768	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851001769	PapC C-terminal domain; Region: PapC_C; pfam13953
439851001770	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
439851001771	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
439851001772	transcriptional regulator FimZ; Provisional; Region: PRK09935
439851001773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851001774	active site
439851001775	phosphorylation site [posttranslational modification]
439851001776	intermolecular recognition site; other site
439851001777	dimerization interface [polypeptide binding]; other site
439851001778	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851001779	DNA binding residues [nucleotide binding]
439851001780	dimerization interface [polypeptide binding]; other site
439851001781	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
439851001782	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851001783	DNA binding residues [nucleotide binding]
439851001784	dimerization interface [polypeptide binding]; other site
439851001785	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
439851001786	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
439851001787	Int/Topo IB signature motif; other site
439851001788	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
439851001789	Protein of unknown function (DUF550); Region: DUF550; pfam04447
439851001790	Protein of unknown function (DUF551); Region: DUF551; pfam04448
439851001791	Protein of unknown function (DUF2737); Region: DUF2737; pfam10930
439851001792	Protein of unknown function (DUF2856); Region: DUF2856; pfam11043
439851001793	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
439851001794	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
439851001795	dimer interface [polypeptide binding]; other site
439851001796	ssDNA binding site [nucleotide binding]; other site
439851001797	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439851001798	putative single-stranded DNA-binding protein; Region: PHA01740
439851001799	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
439851001800	hypothetical protein; Provisional; Region: PRK10292
439851001801	Bacteriophage CII protein; Region: Phage_CII; pfam05269
439851001802	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
439851001803	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
439851001804	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
439851001805	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
439851001806	Walker A motif; other site
439851001807	ATP binding site [chemical binding]; other site
439851001808	Walker B motif; other site
439851001809	DNA binding loops [nucleotide binding]
439851001810	NinB protein; Region: NinB; pfam05772
439851001811	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
439851001812	Active Sites [active]
439851001813	NinF protein; Region: NinF; pfam05810
439851001814	Protein of unknown function (DUF1133); Region: DUF1133; pfam06576
439851001815	phage holin, lambda family; Region: holin_lambda; TIGR01594
439851001816	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
439851001817	catalytic residues [active]
439851001818	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
439851001819	Protein of unknown function (DUF2560); Region: DUF2560; pfam10834
439851001820	Terminase-like family; Region: Terminase_6; pfam03237
439851001821	Bacteriophage terminase large (ATPase) subunit and inactivated derivatives [General function prediction only]; Region: COG5565
439851001822	Phage terminase large subunit; Region: Terminase_3; cl12054
439851001823	Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306
439851001824	coat protein; Region: PHA01511
439851001825	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
439851001826	P22 tail accessory factor; Region: P22_Tail-4; pfam11650
439851001827	Phage stabilisation protein; Region: Phage_stabilise; pfam11134
439851001828	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
439851001829	Protein of unknown function (DUF2824); Region: DUF2824; pfam11039
439851001830	YjzC-like protein; Region: YjzC; pfam14168
439851001831	Mnt; Region: mnt; PHA01513
439851001832	Arc-like DNA binding domain; Region: Arc; pfam03869
439851001833	Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423
439851001834	Head binding; Region: Head_binding; pfam09008
439851001835	Salmonella phage P22 tail-spike; Region: PhageP22-tail; pfam09251
439851001836	O-antigen conversion protein C; Region: PHA01514
439851001837	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
439851001838	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
439851001839	Ligand binding site; other site
439851001840	Putative Catalytic site; other site
439851001841	DXD motif; other site
439851001842	Predicted membrane protein [Function unknown]; Region: COG2246
439851001843	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
439851001844	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
439851001845	Ligand binding site; other site
439851001846	Putative Catalytic site; other site
439851001847	DXD motif; other site
439851001848	Predicted membrane protein [Function unknown]; Region: COG2246
439851001849	GtrA-like protein; Region: GtrA; pfam04138
439851001850	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
439851001851	Cupin; Region: Cupin_6; pfam12852
439851001852	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
439851001853	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851001854	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851001855	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
439851001856	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851001857	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439851001858	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851001859	Predicted membrane protein [Function unknown]; Region: COG3059
439851001860	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
439851001861	phenylalanine transporter; Provisional; Region: PRK10249
439851001862	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
439851001863	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851001864	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
439851001865	dimer interface [polypeptide binding]; other site
439851001866	FMN binding site [chemical binding]; other site
439851001867	hypothetical protein; Provisional; Region: PRK10250
439851001868	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439851001869	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851001870	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
439851001871	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851001872	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
439851001873	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
439851001874	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
439851001875	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
439851001876	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
439851001877	outer membrane receptor FepA; Provisional; Region: PRK13524
439851001878	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851001879	N-terminal plug; other site
439851001880	ligand-binding site [chemical binding]; other site
439851001881	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
439851001882	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
439851001883	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
439851001884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
439851001885	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
439851001886	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
439851001887	acyl-activating enzyme (AAE) consensus motif; other site
439851001888	AMP binding site [chemical binding]; other site
439851001889	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
439851001890	LPS O-antigen length regulator; Provisional; Region: PRK10381
439851001891	Chain length determinant protein; Region: Wzz; pfam02706
439851001892	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
439851001893	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439851001894	Walker A/P-loop; other site
439851001895	ATP binding site [chemical binding]; other site
439851001896	Q-loop/lid; other site
439851001897	ABC transporter signature motif; other site
439851001898	Walker B; other site
439851001899	D-loop; other site
439851001900	H-loop/switch region; other site
439851001901	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
439851001902	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851001903	ABC-ATPase subunit  interface; other site
439851001904	dimer interface [polypeptide binding]; other site
439851001905	putative PBP binding regions; other site
439851001906	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439851001907	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851001908	ABC-ATPase subunit  interface; other site
439851001909	dimer interface [polypeptide binding]; other site
439851001910	putative PBP binding regions; other site
439851001911	enterobactin exporter EntS; Provisional; Region: PRK10489
439851001912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851001913	putative substrate translocation pore; other site
439851001914	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
439851001915	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
439851001916	siderophore binding site; other site
439851001917	isochorismate synthase EntC; Provisional; Region: PRK15016
439851001918	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
439851001919	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
439851001920	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
439851001921	acyl-activating enzyme (AAE) consensus motif; other site
439851001922	active site
439851001923	AMP binding site [chemical binding]; other site
439851001924	substrate binding site [chemical binding]; other site
439851001925	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
439851001926	hydrophobic substrate binding pocket; other site
439851001927	Isochorismatase family; Region: Isochorismatase; pfam00857
439851001928	active site
439851001929	conserved cis-peptide bond; other site
439851001930	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
439851001931	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
439851001932	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
439851001933	putative NAD(P) binding site [chemical binding]; other site
439851001934	active site
439851001935	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
439851001936	CoenzymeA binding site [chemical binding]; other site
439851001937	subunit interaction site [polypeptide binding]; other site
439851001938	PHB binding site; other site
439851001939	carbon starvation protein A; Provisional; Region: PRK15015
439851001940	Carbon starvation protein CstA; Region: CstA; pfam02554
439851001941	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
439851001942	Uncharacterized small protein [Function unknown]; Region: COG2879
439851001943	methionine aminotransferase; Validated; Region: PRK09082
439851001944	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851001945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851001946	homodimer interface [polypeptide binding]; other site
439851001947	catalytic residue [active]
439851001948	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
439851001949	ParB-like nuclease domain; Region: ParBc; pfam02195
439851001950	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
439851001951	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
439851001952	Active Sites [active]
439851001953	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
439851001954	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
439851001955	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851001956	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851001957	dimerization interface [polypeptide binding]; other site
439851001958	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
439851001959	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
439851001960	dimerization domain [polypeptide binding]; other site
439851001961	dimer interface [polypeptide binding]; other site
439851001962	catalytic residues [active]
439851001963	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
439851001964	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
439851001965	dimer interface [polypeptide binding]; other site
439851001966	decamer (pentamer of dimers) interface [polypeptide binding]; other site
439851001967	catalytic triad [active]
439851001968	peroxidatic and resolving cysteines [active]
439851001969	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
439851001970	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
439851001971	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
439851001972	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
439851001973	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439851001974	Ligand Binding Site [chemical binding]; other site
439851001975	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
439851001976	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439851001977	NAD binding site [chemical binding]; other site
439851001978	catalytic Zn binding site [ion binding]; other site
439851001979	structural Zn binding site [ion binding]; other site
439851001980	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
439851001981	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
439851001982	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
439851001983	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
439851001984	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
439851001985	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
439851001986	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
439851001987	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
439851001988	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
439851001989	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
439851001990	putative active site [active]
439851001991	(T/H)XGH motif; other site
439851001992	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
439851001993	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
439851001994	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
439851001995	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439851001996	DNA-binding site [nucleotide binding]; DNA binding site
439851001997	RNA-binding motif; other site
439851001998	chromosome condensation membrane protein; Provisional; Region: PRK14196
439851001999	Predicted amidohydrolase [General function prediction only]; Region: COG0388
439851002000	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
439851002001	putative active site [active]
439851002002	catalytic triad [active]
439851002003	putative dimer interface [polypeptide binding]; other site
439851002004	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
439851002005	lipoyl synthase; Provisional; Region: PRK05481
439851002006	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851002007	FeS/SAM binding site; other site
439851002008	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
439851002009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851002010	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
439851002011	substrate binding pocket [chemical binding]; other site
439851002012	dimerization interface [polypeptide binding]; other site
439851002013	lipoate-protein ligase B; Provisional; Region: PRK14342
439851002014	hypothetical protein; Provisional; Region: PRK04998
439851002015	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
439851002016	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
439851002017	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
439851002018	rare lipoprotein A; Provisional; Region: PRK10672
439851002019	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
439851002020	Sporulation related domain; Region: SPOR; pfam05036
439851002021	cell wall shape-determining protein; Provisional; Region: PRK10794
439851002022	penicillin-binding protein 2; Provisional; Region: PRK10795
439851002023	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439851002024	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439851002025	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
439851002026	ribosome-associated protein; Provisional; Region: PRK11538
439851002027	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439851002028	catalytic core [active]
439851002029	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
439851002030	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851002031	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851002032	homodimer interface [polypeptide binding]; other site
439851002033	catalytic residue [active]
439851002034	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
439851002035	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
439851002036	active site
439851002037	(T/H)XGH motif; other site
439851002038	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
439851002039	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
439851002040	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
439851002041	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
439851002042	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
439851002043	HIGH motif; other site
439851002044	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
439851002045	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
439851002046	active site
439851002047	KMSKS motif; other site
439851002048	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
439851002049	tRNA binding surface [nucleotide binding]; other site
439851002050	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
439851002051	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
439851002052	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
439851002053	hypothetical protein; Provisional; Region: PRK11032
439851002054	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
439851002055	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851002056	Sel1-like repeats; Region: SEL1; smart00671
439851002057	Sel1-like repeats; Region: SEL1; smart00671
439851002058	Sel1-like repeats; Region: SEL1; smart00671
439851002059	Sel1-like repeats; Region: SEL1; smart00671
439851002060	Sel1-like repeats; Region: SEL1; smart00671
439851002061	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
439851002062	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
439851002063	HSP70 interaction site [polypeptide binding]; other site
439851002064	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
439851002065	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
439851002066	HSP70 interaction site [polypeptide binding]; other site
439851002067	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
439851002068	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
439851002069	nucleotide binding site [chemical binding]; other site
439851002070	putative NEF/HSP70 interaction site [polypeptide binding]; other site
439851002071	SBD interface [polypeptide binding]; other site
439851002072	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
439851002073	active site
439851002074	tetramer interface [polypeptide binding]; other site
439851002075	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
439851002076	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439851002077	Walker A/P-loop; other site
439851002078	ATP binding site [chemical binding]; other site
439851002079	Q-loop/lid; other site
439851002080	ABC transporter signature motif; other site
439851002081	Walker B; other site
439851002082	D-loop; other site
439851002083	H-loop/switch region; other site
439851002084	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851002085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002086	dimer interface [polypeptide binding]; other site
439851002087	conserved gate region; other site
439851002088	putative PBP binding loops; other site
439851002089	ABC-ATPase subunit interface; other site
439851002090	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851002091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002092	dimer interface [polypeptide binding]; other site
439851002093	conserved gate region; other site
439851002094	putative PBP binding loops; other site
439851002095	ABC-ATPase subunit interface; other site
439851002096	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
439851002097	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851002098	substrate binding pocket [chemical binding]; other site
439851002099	membrane-bound complex binding site; other site
439851002100	hinge residues; other site
439851002101	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
439851002102	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
439851002103	putative active site [active]
439851002104	catalytic triad [active]
439851002105	putative dimer interface [polypeptide binding]; other site
439851002106	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
439851002107	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439851002108	Transporter associated domain; Region: CorC_HlyC; smart01091
439851002109	metal-binding heat shock protein; Provisional; Region: PRK00016
439851002110	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
439851002111	PhoH-like protein; Region: PhoH; pfam02562
439851002112	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
439851002113	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
439851002114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851002115	FeS/SAM binding site; other site
439851002116	TRAM domain; Region: TRAM; pfam01938
439851002117	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
439851002118	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
439851002119	asparagine synthetase B; Provisional; Region: asnB; PRK09431
439851002120	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
439851002121	active site
439851002122	dimer interface [polypeptide binding]; other site
439851002123	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
439851002124	Ligand Binding Site [chemical binding]; other site
439851002125	Molecular Tunnel; other site
439851002126	UMP phosphatase; Provisional; Region: PRK10444
439851002127	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002128	active site
439851002129	motif I; other site
439851002130	motif II; other site
439851002131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002132	MarR family; Region: MarR; pfam01047
439851002133	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
439851002134	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851002135	nucleotide binding site [chemical binding]; other site
439851002136	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
439851002137	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
439851002138	active site
439851002139	dimer interface [polypeptide binding]; other site
439851002140	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
439851002141	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
439851002142	active site
439851002143	trimer interface [polypeptide binding]; other site
439851002144	allosteric site; other site
439851002145	active site lid [active]
439851002146	hexamer (dimer of trimers) interface [polypeptide binding]; other site
439851002147	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
439851002148	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439851002149	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439851002150	active site turn [active]
439851002151	phosphorylation site [posttranslational modification]
439851002152	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
439851002153	HPr interaction site; other site
439851002154	glycerol kinase (GK) interaction site [polypeptide binding]; other site
439851002155	active site
439851002156	phosphorylation site [posttranslational modification]
439851002157	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
439851002158	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
439851002159	active site
439851002160	HIGH motif; other site
439851002161	nucleotide binding site [chemical binding]; other site
439851002162	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
439851002163	KMSKS motif; other site
439851002164	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
439851002165	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
439851002166	YbfN-like lipoprotein; Region: YbfN; pfam13982
439851002167	citrate-proton symporter; Provisional; Region: PRK15075
439851002168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851002169	putative substrate translocation pore; other site
439851002170	tricarballylate utilization protein B; Provisional; Region: PRK15033
439851002171	tricarballylate dehydrogenase; Validated; Region: PRK08274
439851002172	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851002173	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851002174	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851002175	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
439851002176	putative dimerization interface [polypeptide binding]; other site
439851002177	ferric uptake regulator; Provisional; Region: fur; PRK09462
439851002178	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
439851002179	metal binding site 2 [ion binding]; metal-binding site
439851002180	putative DNA binding helix; other site
439851002181	metal binding site 1 [ion binding]; metal-binding site
439851002182	dimer interface [polypeptide binding]; other site
439851002183	structural Zn2+ binding site [ion binding]; other site
439851002184	flavodoxin FldA; Validated; Region: PRK09267
439851002185	LexA regulated protein; Provisional; Region: PRK11675
439851002186	acyl-CoA esterase; Provisional; Region: PRK10673
439851002187	PGAP1-like protein; Region: PGAP1; pfam07819
439851002188	replication initiation regulator SeqA; Provisional; Region: PRK11187
439851002189	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
439851002190	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
439851002191	active site
439851002192	substrate binding site [chemical binding]; other site
439851002193	metal binding site [ion binding]; metal-binding site
439851002194	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
439851002195	putrescine transporter; Provisional; Region: potE; PRK10655
439851002196	ornithine decarboxylase; Provisional; Region: PRK13578
439851002197	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439851002198	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439851002199	homodimer interface [polypeptide binding]; other site
439851002200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851002201	catalytic residue [active]
439851002202	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439851002203	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
439851002204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851002205	active site
439851002206	phosphorylation site [posttranslational modification]
439851002207	intermolecular recognition site; other site
439851002208	dimerization interface [polypeptide binding]; other site
439851002209	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851002210	DNA binding site [nucleotide binding]
439851002211	sensor protein KdpD; Provisional; Region: PRK10490
439851002212	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
439851002213	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
439851002214	Ligand Binding Site [chemical binding]; other site
439851002215	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
439851002216	GAF domain; Region: GAF_3; pfam13492
439851002217	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851002218	dimer interface [polypeptide binding]; other site
439851002219	phosphorylation site [posttranslational modification]
439851002220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851002221	ATP binding site [chemical binding]; other site
439851002222	Mg2+ binding site [ion binding]; other site
439851002223	G-X-G motif; other site
439851002224	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
439851002225	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
439851002226	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439851002227	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
439851002228	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
439851002229	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
439851002230	DNA photolyase; Region: DNA_photolyase; pfam00875
439851002231	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
439851002232	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851002233	putative substrate translocation pore; other site
439851002234	POT family; Region: PTR2; pfam00854
439851002235	Uncharacterized conserved protein [Function unknown]; Region: COG0327
439851002236	metal-binding protein; Provisional; Region: PRK10799
439851002237	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
439851002238	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
439851002239	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
439851002240	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
439851002241	putative active site [active]
439851002242	endonuclease VIII; Provisional; Region: PRK10445
439851002243	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
439851002244	DNA binding site [nucleotide binding]
439851002245	catalytic residue [active]
439851002246	putative catalytic residues [active]
439851002247	H2TH interface [polypeptide binding]; other site
439851002248	intercalation triad [nucleotide binding]; other site
439851002249	substrate specificity determining residue; other site
439851002250	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
439851002251	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
439851002252	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
439851002253	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
439851002254	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
439851002255	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
439851002256	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
439851002257	dimer interface [polypeptide binding]; other site
439851002258	active site
439851002259	citrylCoA binding site [chemical binding]; other site
439851002260	NADH binding [chemical binding]; other site
439851002261	cationic pore residues; other site
439851002262	oxalacetate/citrate binding site [chemical binding]; other site
439851002263	coenzyme A binding site [chemical binding]; other site
439851002264	catalytic triad [active]
439851002265	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
439851002266	Iron-sulfur protein interface; other site
439851002267	proximal quinone binding site [chemical binding]; other site
439851002268	SdhD (CybS) interface [polypeptide binding]; other site
439851002269	proximal heme binding site [chemical binding]; other site
439851002270	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
439851002271	SdhC subunit interface [polypeptide binding]; other site
439851002272	proximal heme binding site [chemical binding]; other site
439851002273	cardiolipin binding site; other site
439851002274	Iron-sulfur protein interface; other site
439851002275	proximal quinone binding site [chemical binding]; other site
439851002276	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
439851002277	L-aspartate oxidase; Provisional; Region: PRK06175
439851002278	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
439851002279	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
439851002280	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
439851002281	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
439851002282	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
439851002283	TPP-binding site [chemical binding]; other site
439851002284	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
439851002285	dimer interface [polypeptide binding]; other site
439851002286	PYR/PP interface [polypeptide binding]; other site
439851002287	TPP binding site [chemical binding]; other site
439851002288	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
439851002289	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439851002290	E3 interaction surface; other site
439851002291	lipoyl attachment site [posttranslational modification]; other site
439851002292	e3 binding domain; Region: E3_binding; pfam02817
439851002293	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
439851002294	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
439851002295	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
439851002296	CoA-ligase; Region: Ligase_CoA; pfam00549
439851002297	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
439851002298	CoA binding domain; Region: CoA_binding; smart00881
439851002299	CoA-ligase; Region: Ligase_CoA; pfam00549
439851002300	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
439851002301	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
439851002302	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
439851002303	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
439851002304	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
439851002305	hypothetical protein; Provisional; Region: PRK10588
439851002306	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
439851002307	active site
439851002308	colicin uptake protein TolQ; Provisional; Region: PRK10801
439851002309	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
439851002310	colicin uptake protein TolR; Provisional; Region: PRK11024
439851002311	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
439851002312	TolA C-terminal; Region: TolA; pfam06519
439851002313	translocation protein TolB; Provisional; Region: tolB; PRK03629
439851002314	TolB amino-terminal domain; Region: TolB_N; pfam04052
439851002315	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
439851002316	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
439851002317	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
439851002318	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
439851002319	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439851002320	ligand binding site [chemical binding]; other site
439851002321	tol-pal system protein YbgF; Provisional; Region: PRK10803
439851002322	Tetratricopeptide repeat; Region: TPR_6; pfam13174
439851002323	Tetratricopeptide repeat; Region: TPR_6; pfam13174
439851002324	quinolinate synthetase; Provisional; Region: PRK09375
439851002325	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
439851002326	zinc transporter ZitB; Provisional; Region: PRK03557
439851002327	YbgS-like protein; Region: YbgS; pfam13985
439851002328	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
439851002329	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439851002330	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
439851002331	fumarate hydratase; Provisional; Region: PRK06246
439851002332	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851002333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851002334	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851002335	dimerization interface [polypeptide binding]; other site
439851002336	cell density-dependent motility repressor; Provisional; Region: PRK10082
439851002337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851002338	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851002339	dimerization interface [polypeptide binding]; other site
439851002340	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
439851002341	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
439851002342	transmembrane helices; other site
439851002343	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
439851002344	oxaloacetate decarboxylase; Provisional; Region: PRK14040
439851002345	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
439851002346	active site
439851002347	catalytic residues [active]
439851002348	metal binding site [ion binding]; metal-binding site
439851002349	homodimer binding site [polypeptide binding]; other site
439851002350	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
439851002351	carboxyltransferase (CT) interaction site; other site
439851002352	biotinylation site [posttranslational modification]; other site
439851002353	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
439851002354	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
439851002355	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439851002356	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851002357	dimer interface [polypeptide binding]; other site
439851002358	putative PBP binding regions; other site
439851002359	ABC-ATPase subunit  interface; other site
439851002360	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
439851002361	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439851002362	Walker A/P-loop; other site
439851002363	ATP binding site [chemical binding]; other site
439851002364	Q-loop/lid; other site
439851002365	ABC transporter signature motif; other site
439851002366	Walker B; other site
439851002367	D-loop; other site
439851002368	H-loop/switch region; other site
439851002369	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439851002370	catalytic core [active]
439851002371	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439851002372	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
439851002373	active site
439851002374	catalytic residues [active]
439851002375	galactokinase; Provisional; Region: PRK05101
439851002376	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
439851002377	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
439851002378	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
439851002379	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
439851002380	dimer interface [polypeptide binding]; other site
439851002381	active site
439851002382	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
439851002383	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
439851002384	NAD binding site [chemical binding]; other site
439851002385	homodimer interface [polypeptide binding]; other site
439851002386	active site
439851002387	substrate binding site [chemical binding]; other site
439851002388	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
439851002389	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
439851002390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002391	Walker A/P-loop; other site
439851002392	ATP binding site [chemical binding]; other site
439851002393	Q-loop/lid; other site
439851002394	ABC transporter signature motif; other site
439851002395	Walker B; other site
439851002396	D-loop; other site
439851002397	H-loop/switch region; other site
439851002398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002399	Walker A/P-loop; other site
439851002400	ATP binding site [chemical binding]; other site
439851002401	Q-loop/lid; other site
439851002402	ABC transporter signature motif; other site
439851002403	Walker B; other site
439851002404	D-loop; other site
439851002405	H-loop/switch region; other site
439851002406	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
439851002407	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
439851002408	molybdenum-pterin binding domain; Region: Mop; TIGR00638
439851002409	TOBE domain; Region: TOBE; pfam03459
439851002410	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
439851002411	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
439851002412	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851002413	substrate binding pocket [chemical binding]; other site
439851002414	membrane-bound complex binding site; other site
439851002415	hinge residues; other site
439851002416	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
439851002417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002418	dimer interface [polypeptide binding]; other site
439851002419	conserved gate region; other site
439851002420	putative PBP binding loops; other site
439851002421	ABC-ATPase subunit interface; other site
439851002422	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
439851002423	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002424	Walker A/P-loop; other site
439851002425	ATP binding site [chemical binding]; other site
439851002426	Q-loop/lid; other site
439851002427	ABC transporter signature motif; other site
439851002428	Walker B; other site
439851002429	D-loop; other site
439851002430	H-loop/switch region; other site
439851002431	molybdenum-pterin binding domain; Region: Mop; TIGR00638
439851002432	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
439851002433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002434	active site
439851002435	motif I; other site
439851002436	motif II; other site
439851002437	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002438	6-phosphogluconolactonase; Provisional; Region: PRK11028
439851002439	acyl-CoA thioesterase; Provisional; Region: PRK10531
439851002440	putative pectinesterase; Region: PLN02432; cl01911
439851002441	imidazolonepropionase; Validated; Region: PRK09356
439851002442	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
439851002443	active site
439851002444	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
439851002445	putative active site [active]
439851002446	putative metal binding site [ion binding]; other site
439851002447	histidine utilization repressor; Provisional; Region: PRK14999
439851002448	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851002449	DNA-binding site [nucleotide binding]; DNA binding site
439851002450	UTRA domain; Region: UTRA; pfam07702
439851002451	urocanate hydratase; Provisional; Region: PRK05414
439851002452	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
439851002453	active sites [active]
439851002454	tetramer interface [polypeptide binding]; other site
439851002455	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
439851002456	substrate binding site [chemical binding]; other site
439851002457	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
439851002458	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439851002459	inhibitor-cofactor binding pocket; inhibition site
439851002460	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851002461	catalytic residue [active]
439851002462	biotin synthase; Provisional; Region: PRK15108
439851002463	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851002464	FeS/SAM binding site; other site
439851002465	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
439851002466	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
439851002467	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
439851002468	substrate-cofactor binding pocket; other site
439851002469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851002470	catalytic residue [active]
439851002471	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
439851002472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851002473	S-adenosylmethionine binding site [chemical binding]; other site
439851002474	AAA domain; Region: AAA_26; pfam13500
439851002475	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
439851002476	excinuclease ABC subunit B; Provisional; Region: PRK05298
439851002477	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851002478	ATP binding site [chemical binding]; other site
439851002479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851002480	nucleotide binding region [chemical binding]; other site
439851002481	ATP-binding site [chemical binding]; other site
439851002482	Ultra-violet resistance protein B; Region: UvrB; pfam12344
439851002483	UvrB/uvrC motif; Region: UVR; pfam02151
439851002484	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
439851002485	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
439851002486	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
439851002487	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
439851002488	Leucine-rich repeats; other site
439851002489	Substrate binding site [chemical binding]; other site
439851002490	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
439851002491	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
439851002492	putative substrate binding pocket [chemical binding]; other site
439851002493	dimer interface [polypeptide binding]; other site
439851002494	phosphate binding site [ion binding]; other site
439851002495	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
439851002496	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851002497	FeS/SAM binding site; other site
439851002498	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
439851002499	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
439851002500	MPT binding site; other site
439851002501	trimer interface [polypeptide binding]; other site
439851002502	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
439851002503	trimer interface [polypeptide binding]; other site
439851002504	dimer interface [polypeptide binding]; other site
439851002505	putative active site [active]
439851002506	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
439851002507	MoaE interaction surface [polypeptide binding]; other site
439851002508	MoeB interaction surface [polypeptide binding]; other site
439851002509	thiocarboxylated glycine; other site
439851002510	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
439851002511	MoaE homodimer interface [polypeptide binding]; other site
439851002512	MoaD interaction [polypeptide binding]; other site
439851002513	active site residues [active]
439851002514	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439851002515	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
439851002516	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439851002517	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
439851002518	Predicted integral membrane protein [Function unknown]; Region: COG0392
439851002519	cardiolipin synthase 2; Provisional; Region: PRK11263
439851002520	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
439851002521	putative active site [active]
439851002522	catalytic site [active]
439851002523	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
439851002524	putative active site [active]
439851002525	catalytic site [active]
439851002526	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
439851002527	putative catalytic site [active]
439851002528	putative metal binding site [ion binding]; other site
439851002529	putative phosphate binding site [ion binding]; other site
439851002530	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
439851002531	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439851002532	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
439851002533	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439851002534	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
439851002535	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
439851002536	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439851002537	Walker A/P-loop; other site
439851002538	ATP binding site [chemical binding]; other site
439851002539	Q-loop/lid; other site
439851002540	ABC transporter signature motif; other site
439851002541	Walker B; other site
439851002542	D-loop; other site
439851002543	H-loop/switch region; other site
439851002544	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
439851002545	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439851002546	Walker A/P-loop; other site
439851002547	ATP binding site [chemical binding]; other site
439851002548	Q-loop/lid; other site
439851002549	ABC transporter signature motif; other site
439851002550	Walker B; other site
439851002551	D-loop; other site
439851002552	H-loop/switch region; other site
439851002553	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
439851002554	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439851002555	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851002556	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
439851002557	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851002558	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
439851002559	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
439851002560	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439851002561	ATP binding site [chemical binding]; other site
439851002562	Mg++ binding site [ion binding]; other site
439851002563	motif III; other site
439851002564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851002565	nucleotide binding region [chemical binding]; other site
439851002566	ATP-binding site [chemical binding]; other site
439851002567	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
439851002568	DEAD_2; Region: DEAD_2; pfam06733
439851002569	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
439851002570	glycosyl transferase family protein; Provisional; Region: PRK08136
439851002571	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
439851002572	hypothetical protein; Provisional; Region: PRK10259
439851002573	hypothetical protein; Provisional; Region: PRK11019
439851002574	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
439851002575	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
439851002576	putative mechanosensitive channel protein; Provisional; Region: PRK11465
439851002577	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851002578	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
439851002579	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439851002580	Walker A/P-loop; other site
439851002581	ATP binding site [chemical binding]; other site
439851002582	Q-loop/lid; other site
439851002583	ABC transporter signature motif; other site
439851002584	Walker B; other site
439851002585	D-loop; other site
439851002586	H-loop/switch region; other site
439851002587	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851002588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002589	dimer interface [polypeptide binding]; other site
439851002590	conserved gate region; other site
439851002591	putative PBP binding loops; other site
439851002592	ABC-ATPase subunit interface; other site
439851002593	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
439851002594	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851002595	substrate binding pocket [chemical binding]; other site
439851002596	membrane-bound complex binding site; other site
439851002597	hinge residues; other site
439851002598	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
439851002599	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
439851002600	dimerization interface [polypeptide binding]; other site
439851002601	DPS ferroxidase diiron center [ion binding]; other site
439851002602	ion pore; other site
439851002603	threonine and homoserine efflux system; Provisional; Region: PRK10532
439851002604	EamA-like transporter family; Region: EamA; pfam00892
439851002605	outer membrane protein X; Provisional; Region: ompX; PRK09408
439851002606	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
439851002607	Sulfatase; Region: Sulfatase; pfam00884
439851002608	manganese transport regulator MntR; Provisional; Region: PRK11050
439851002609	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
439851002610	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
439851002611	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
439851002612	transmembrane helices; other site
439851002613	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
439851002614	L,D-transpeptidase; Provisional; Region: PRK10260
439851002615	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439851002616	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
439851002617	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851002618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002619	Walker A/P-loop; other site
439851002620	ATP binding site [chemical binding]; other site
439851002621	ABC transporter signature motif; other site
439851002622	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851002623	Walker B; other site
439851002624	ABC transporter; Region: ABC_tran_2; pfam12848
439851002625	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851002626	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
439851002627	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
439851002628	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002629	active site
439851002630	motif I; other site
439851002631	motif II; other site
439851002632	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002633	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
439851002634	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
439851002635	dimer interface [polypeptide binding]; other site
439851002636	active site
439851002637	glycine loop; other site
439851002638	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
439851002639	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851002640	FeS/SAM binding site; other site
439851002641	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
439851002642	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
439851002643	ATP binding site [chemical binding]; other site
439851002644	substrate interface [chemical binding]; other site
439851002645	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
439851002646	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
439851002647	dimer interface [polypeptide binding]; other site
439851002648	putative functional site; other site
439851002649	putative MPT binding site; other site
439851002650	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
439851002651	catalytic nucleophile [active]
439851002652	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
439851002653	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851002654	Walker A/P-loop; other site
439851002655	ATP binding site [chemical binding]; other site
439851002656	Q-loop/lid; other site
439851002657	ABC transporter signature motif; other site
439851002658	Walker B; other site
439851002659	D-loop; other site
439851002660	H-loop/switch region; other site
439851002661	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439851002662	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851002663	Walker A/P-loop; other site
439851002664	ATP binding site [chemical binding]; other site
439851002665	Q-loop/lid; other site
439851002666	ABC transporter signature motif; other site
439851002667	Walker B; other site
439851002668	D-loop; other site
439851002669	H-loop/switch region; other site
439851002670	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
439851002671	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
439851002672	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
439851002673	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
439851002674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002675	dimer interface [polypeptide binding]; other site
439851002676	conserved gate region; other site
439851002677	putative PBP binding loops; other site
439851002678	ABC-ATPase subunit interface; other site
439851002679	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
439851002680	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439851002681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002682	dimer interface [polypeptide binding]; other site
439851002683	conserved gate region; other site
439851002684	putative PBP binding loops; other site
439851002685	ABC-ATPase subunit interface; other site
439851002686	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
439851002687	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
439851002688	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851002689	FeS/SAM binding site; other site
439851002690	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
439851002691	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
439851002692	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
439851002693	Ligand binding site [chemical binding]; other site
439851002694	Electron transfer flavoprotein domain; Region: ETF; pfam01012
439851002695	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
439851002696	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
439851002697	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
439851002698	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
439851002699	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
439851002700	active site
439851002701	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
439851002702	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851002703	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
439851002704	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
439851002705	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851002706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851002707	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
439851002708	putative dimerization interface [polypeptide binding]; other site
439851002709	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
439851002710	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
439851002711	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
439851002712	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
439851002713	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
439851002714	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
439851002715	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
439851002716	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
439851002717	putative C-terminal domain interface [polypeptide binding]; other site
439851002718	putative GSH binding site (G-site) [chemical binding]; other site
439851002719	putative dimer interface [polypeptide binding]; other site
439851002720	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
439851002721	putative N-terminal domain interface [polypeptide binding]; other site
439851002722	putative dimer interface [polypeptide binding]; other site
439851002723	putative substrate binding pocket (H-site) [chemical binding]; other site
439851002724	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
439851002725	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
439851002726	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
439851002727	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
439851002728	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439851002729	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851002730	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439851002731	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
439851002732	active site
439851002733	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
439851002734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851002735	putative substrate translocation pore; other site
439851002736	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
439851002737	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002738	active site
439851002739	motif I; other site
439851002740	motif II; other site
439851002741	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851002742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851002743	putative substrate translocation pore; other site
439851002744	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851002745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
439851002746	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851002747	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
439851002748	putative transporter; Provisional; Region: PRK04972
439851002749	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
439851002750	TrkA-C domain; Region: TrkA_C; pfam02080
439851002751	TrkA-C domain; Region: TrkA_C; pfam02080
439851002752	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
439851002753	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
439851002754	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
439851002755	GSH binding site [chemical binding]; other site
439851002756	catalytic residues [active]
439851002757	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
439851002758	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
439851002759	dimer interface [polypeptide binding]; other site
439851002760	FMN binding site [chemical binding]; other site
439851002761	NADPH bind site [chemical binding]; other site
439851002762	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
439851002763	RimK-like ATP-grasp domain; Region: RimK; pfam08443
439851002764	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
439851002765	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
439851002766	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
439851002767	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
439851002768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002769	Walker A/P-loop; other site
439851002770	ATP binding site [chemical binding]; other site
439851002771	Q-loop/lid; other site
439851002772	ABC transporter signature motif; other site
439851002773	Walker B; other site
439851002774	D-loop; other site
439851002775	H-loop/switch region; other site
439851002776	TOBE domain; Region: TOBE_2; pfam08402
439851002777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002778	dimer interface [polypeptide binding]; other site
439851002779	conserved gate region; other site
439851002780	putative PBP binding loops; other site
439851002781	ABC-ATPase subunit interface; other site
439851002782	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
439851002783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002784	dimer interface [polypeptide binding]; other site
439851002785	conserved gate region; other site
439851002786	putative PBP binding loops; other site
439851002787	ABC-ATPase subunit interface; other site
439851002788	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
439851002789	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
439851002790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851002791	S-adenosylmethionine binding site [chemical binding]; other site
439851002792	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
439851002793	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
439851002794	active site
439851002795	P-loop; other site
439851002796	phosphorylation site [posttranslational modification]
439851002797	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
439851002798	Sulfatase; Region: Sulfatase; cl17466
439851002799	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
439851002800	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851002801	substrate binding pocket [chemical binding]; other site
439851002802	membrane-bound complex binding site; other site
439851002803	hinge residues; other site
439851002804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002805	dimer interface [polypeptide binding]; other site
439851002806	conserved gate region; other site
439851002807	putative PBP binding loops; other site
439851002808	ABC-ATPase subunit interface; other site
439851002809	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851002810	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851002811	dimer interface [polypeptide binding]; other site
439851002812	conserved gate region; other site
439851002813	putative PBP binding loops; other site
439851002814	ABC-ATPase subunit interface; other site
439851002815	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
439851002816	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851002817	substrate binding pocket [chemical binding]; other site
439851002818	membrane-bound complex binding site; other site
439851002819	hinge residues; other site
439851002820	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
439851002821	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002822	Walker A/P-loop; other site
439851002823	ATP binding site [chemical binding]; other site
439851002824	Q-loop/lid; other site
439851002825	ABC transporter signature motif; other site
439851002826	Walker B; other site
439851002827	D-loop; other site
439851002828	H-loop/switch region; other site
439851002829	putative lipoprotein; Provisional; Region: PRK10533
439851002830	hypothetical protein; Provisional; Region: PRK02877
439851002831	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
439851002832	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
439851002833	amidase catalytic site [active]
439851002834	Zn binding residues [ion binding]; other site
439851002835	substrate binding site [chemical binding]; other site
439851002836	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
439851002837	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
439851002838	NAD(P) binding site [chemical binding]; other site
439851002839	active site
439851002840	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
439851002841	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
439851002842	putative NAD(P) binding site [chemical binding]; other site
439851002843	putative active site [active]
439851002844	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
439851002845	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
439851002846	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
439851002847	tetramer interface [polypeptide binding]; other site
439851002848	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851002849	catalytic residue [active]
439851002850	pyruvate dehydrogenase; Provisional; Region: PRK09124
439851002851	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
439851002852	PYR/PP interface [polypeptide binding]; other site
439851002853	dimer interface [polypeptide binding]; other site
439851002854	tetramer interface [polypeptide binding]; other site
439851002855	TPP binding site [chemical binding]; other site
439851002856	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439851002857	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
439851002858	TPP-binding site [chemical binding]; other site
439851002859	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
439851002860	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
439851002861	FAD binding pocket [chemical binding]; other site
439851002862	FAD binding motif [chemical binding]; other site
439851002863	phosphate binding motif [ion binding]; other site
439851002864	beta-alpha-beta structure motif; other site
439851002865	NAD binding pocket [chemical binding]; other site
439851002866	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439851002867	catalytic loop [active]
439851002868	iron binding site [ion binding]; other site
439851002869	hybrid cluster protein; Provisional; Region: PRK05290
439851002870	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439851002871	ACS interaction site; other site
439851002872	CODH interaction site; other site
439851002873	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
439851002874	hybrid metal cluster; other site
439851002875	Predicted membrane protein [Function unknown]; Region: COG2431
439851002876	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
439851002877	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
439851002878	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
439851002879	putative active site [active]
439851002880	putative metal-binding site [ion binding]; other site
439851002881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
439851002882	macrolide transporter subunit MacA; Provisional; Region: PRK11578
439851002883	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851002884	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851002885	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
439851002886	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
439851002887	Walker A/P-loop; other site
439851002888	ATP binding site [chemical binding]; other site
439851002889	Q-loop/lid; other site
439851002890	ABC transporter signature motif; other site
439851002891	Walker B; other site
439851002892	D-loop; other site
439851002893	H-loop/switch region; other site
439851002894	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
439851002895	FtsX-like permease family; Region: FtsX; pfam02687
439851002896	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439851002897	DNA-binding site [nucleotide binding]; DNA binding site
439851002898	RNA-binding motif; other site
439851002899	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
439851002900	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
439851002901	Clp amino terminal domain; Region: Clp_N; pfam02861
439851002902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851002903	Walker A motif; other site
439851002904	ATP binding site [chemical binding]; other site
439851002905	Walker B motif; other site
439851002906	arginine finger; other site
439851002907	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851002908	Walker A motif; other site
439851002909	ATP binding site [chemical binding]; other site
439851002910	Walker B motif; other site
439851002911	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
439851002912	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439851002913	DNA binding site [nucleotide binding]
439851002914	active site
439851002915	Int/Topo IB signature motif; other site
439851002916	Isochorismatase family; Region: Isochorismatase; pfam00857
439851002917	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
439851002918	catalytic triad [active]
439851002919	dimer interface [polypeptide binding]; other site
439851002920	conserved cis-peptide bond; other site
439851002921	Pirin-related protein [General function prediction only]; Region: COG1741
439851002922	Pirin; Region: Pirin; pfam02678
439851002923	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
439851002924	LysR family transcriptional regulator; Provisional; Region: PRK14997
439851002925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851002926	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
439851002927	putative effector binding pocket; other site
439851002928	putative dimerization interface [polypeptide binding]; other site
439851002929	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
439851002930	rRNA binding site [nucleotide binding]; other site
439851002931	predicted 30S ribosome binding site; other site
439851002932	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
439851002933	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
439851002934	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439851002935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002936	Walker A/P-loop; other site
439851002937	ATP binding site [chemical binding]; other site
439851002938	Q-loop/lid; other site
439851002939	ABC transporter signature motif; other site
439851002940	Walker B; other site
439851002941	D-loop; other site
439851002942	H-loop/switch region; other site
439851002943	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
439851002944	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439851002945	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851002946	Walker A/P-loop; other site
439851002947	ATP binding site [chemical binding]; other site
439851002948	Q-loop/lid; other site
439851002949	ABC transporter signature motif; other site
439851002950	Walker B; other site
439851002951	D-loop; other site
439851002952	H-loop/switch region; other site
439851002953	thioredoxin reductase; Provisional; Region: PRK10262
439851002954	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851002955	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851002956	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
439851002957	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439851002958	putative DNA binding site [nucleotide binding]; other site
439851002959	putative Zn2+ binding site [ion binding]; other site
439851002960	AsnC family; Region: AsnC_trans_reg; pfam01037
439851002961	DNA translocase FtsK; Provisional; Region: PRK10263
439851002962	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
439851002963	DNA translocase FtsK; Provisional; Region: PRK10263
439851002964	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
439851002965	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
439851002966	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
439851002967	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
439851002968	recombination factor protein RarA; Reviewed; Region: PRK13342
439851002969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851002970	Walker A motif; other site
439851002971	ATP binding site [chemical binding]; other site
439851002972	Walker B motif; other site
439851002973	arginine finger; other site
439851002974	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
439851002975	seryl-tRNA synthetase; Provisional; Region: PRK05431
439851002976	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
439851002977	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
439851002978	dimer interface [polypeptide binding]; other site
439851002979	active site
439851002980	motif 1; other site
439851002981	motif 2; other site
439851002982	motif 3; other site
439851002983	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
439851002984	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439851002985	putative [Fe4-S4] binding site [ion binding]; other site
439851002986	putative molybdopterin cofactor binding site [chemical binding]; other site
439851002987	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439851002988	putative molybdopterin cofactor binding site; other site
439851002989	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439851002990	4Fe-4S binding domain; Region: Fer4; pfam00037
439851002991	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
439851002992	putative MFS family transporter protein; Provisional; Region: PRK03633
439851002993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851002994	putative substrate translocation pore; other site
439851002995	inner membrane transporter YjeM; Provisional; Region: PRK15238
439851002996	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
439851002997	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851002998	FeS/SAM binding site; other site
439851002999	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
439851003000	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
439851003001	Pyruvate formate lyase 1; Region: PFL1; cd01678
439851003002	coenzyme A binding site [chemical binding]; other site
439851003003	active site
439851003004	catalytic residues [active]
439851003005	glycine loop; other site
439851003006	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
439851003007	uncharacterized domain; Region: TIGR00702
439851003008	YcaO-like family; Region: YcaO; pfam02624
439851003009	Predicted membrane protein [Function unknown]; Region: COG2323
439851003010	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
439851003011	homodimer interface [polypeptide binding]; other site
439851003012	substrate-cofactor binding pocket; other site
439851003013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851003014	catalytic residue [active]
439851003015	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
439851003016	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
439851003017	hinge; other site
439851003018	active site
439851003019	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
439851003020	cytidylate kinase; Provisional; Region: cmk; PRK00023
439851003021	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
439851003022	CMP-binding site; other site
439851003023	The sites determining sugar specificity; other site
439851003024	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
439851003025	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
439851003026	RNA binding site [nucleotide binding]; other site
439851003027	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
439851003028	RNA binding site [nucleotide binding]; other site
439851003029	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
439851003030	RNA binding site [nucleotide binding]; other site
439851003031	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
439851003032	RNA binding site [nucleotide binding]; other site
439851003033	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
439851003034	RNA binding site [nucleotide binding]; other site
439851003035	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439851003036	IHF dimer interface [polypeptide binding]; other site
439851003037	IHF - DNA interface [nucleotide binding]; other site
439851003038	ComEC family competence protein; Provisional; Region: PRK11539
439851003039	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
439851003040	Competence protein; Region: Competence; pfam03772
439851003041	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
439851003042	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
439851003043	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439851003044	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
439851003045	Walker A/P-loop; other site
439851003046	ATP binding site [chemical binding]; other site
439851003047	Q-loop/lid; other site
439851003048	ABC transporter signature motif; other site
439851003049	Walker B; other site
439851003050	D-loop; other site
439851003051	H-loop/switch region; other site
439851003052	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
439851003053	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
439851003054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
439851003055	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
439851003056	hypothetical protein; Provisional; Region: PRK11827
439851003057	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
439851003058	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
439851003059	Ligand binding site; other site
439851003060	oligomer interface; other site
439851003061	hypothetical protein; Provisional; Region: PRK10593
439851003062	Uncharacterized conserved protein [Function unknown]; Region: COG1434
439851003063	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439851003064	putative active site [active]
439851003065	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
439851003066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851003067	S-adenosylmethionine binding site [chemical binding]; other site
439851003068	condesin subunit F; Provisional; Region: PRK05260
439851003069	condesin subunit E; Provisional; Region: PRK05256
439851003070	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
439851003071	P-loop containing region of AAA domain; Region: AAA_29; cl17516
439851003072	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
439851003073	murein L,D-transpeptidase; Provisional; Region: PRK10594
439851003074	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
439851003075	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439851003076	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439851003077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
439851003078	Peptidase M15; Region: Peptidase_M15_3; cl01194
439851003079	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
439851003080	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
439851003081	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851003082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851003083	homodimer interface [polypeptide binding]; other site
439851003084	catalytic residue [active]
439851003085	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851003086	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439851003087	trimer interface [polypeptide binding]; other site
439851003088	eyelet of channel; other site
439851003089	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
439851003090	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
439851003091	putative dimer interface [polypeptide binding]; other site
439851003092	putative anticodon binding site; other site
439851003093	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
439851003094	homodimer interface [polypeptide binding]; other site
439851003095	motif 1; other site
439851003096	motif 2; other site
439851003097	active site
439851003098	motif 3; other site
439851003099	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
439851003100	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439851003101	putative DNA binding site [nucleotide binding]; other site
439851003102	putative Zn2+ binding site [ion binding]; other site
439851003103	AsnC family; Region: AsnC_trans_reg; pfam01037
439851003104	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
439851003105	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
439851003106	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851003107	catalytic residue [active]
439851003108	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
439851003109	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
439851003110	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
439851003111	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
439851003112	active site
439851003113	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
439851003114	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
439851003115	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
439851003116	Int/Topo IB signature motif; other site
439851003117	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
439851003118	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
439851003119	exonuclease VIII; Reviewed; Region: PRK09709
439851003120	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
439851003121	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
439851003122	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
439851003123	primosomal protein DnaI; Provisional; Region: PRK02854
439851003124	putative replication protein; Provisional; Region: PRK12377
439851003125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851003126	Walker A motif; other site
439851003127	ATP binding site [chemical binding]; other site
439851003128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
439851003129	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
439851003130	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
439851003131	Methyltransferase domain; Region: Methyltransf_25; pfam13649
439851003132	Protein of unknown function (DUF550); Region: DUF550; pfam04447
439851003133	DinI-like family; Region: DinI; pfam06183
439851003134	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
439851003135	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
439851003136	Antitermination protein; Region: Antiterm; pfam03589
439851003137	Antitermination protein; Region: Antiterm; pfam03589
439851003138	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
439851003139	Predicted chitinase [General function prediction only]; Region: COG3179
439851003140	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
439851003141	Terminase small subunit; Region: Terminase_2; pfam03592
439851003142	Terminase-like family; Region: Terminase_6; pfam03237
439851003143	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
439851003144	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
439851003145	nudix motif; other site
439851003146	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
439851003147	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
439851003148	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
439851003149	active site
439851003150	metal binding site [ion binding]; metal-binding site
439851003151	virion protein; Provisional; Region: V; PHA02564
439851003152	Baseplate J-like protein; Region: Baseplate_J; cl01294
439851003153	Phage Tail Collar Domain; Region: Collar; pfam07484
439851003154	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439851003155	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
439851003156	hypothetical protein; Provisional; Region: PRK09951
439851003157	DinI-like family; Region: DinI; cl11630
439851003158	aminopeptidase N; Provisional; Region: pepN; PRK14015
439851003159	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
439851003160	active site
439851003161	Zn binding site [ion binding]; other site
439851003162	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
439851003163	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
439851003164	quinone interaction residues [chemical binding]; other site
439851003165	active site
439851003166	catalytic residues [active]
439851003167	FMN binding site [chemical binding]; other site
439851003168	substrate binding site [chemical binding]; other site
439851003169	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
439851003170	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
439851003171	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
439851003172	MOSC domain; Region: MOSC; pfam03473
439851003173	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
439851003174	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439851003175	catalytic loop [active]
439851003176	iron binding site [ion binding]; other site
439851003177	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
439851003178	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
439851003179	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
439851003180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851003181	S-adenosylmethionine binding site [chemical binding]; other site
439851003182	ABC transporter ATPase component; Reviewed; Region: PRK11147
439851003183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851003184	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851003185	Walker A/P-loop; other site
439851003186	Walker A/P-loop; other site
439851003187	ATP binding site [chemical binding]; other site
439851003188	ATP binding site [chemical binding]; other site
439851003189	Q-loop/lid; other site
439851003190	Q-loop/lid; other site
439851003191	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851003192	ABC transporter signature motif; other site
439851003193	Walker B; other site
439851003194	D-loop; other site
439851003195	ABC transporter; Region: ABC_tran_2; pfam12848
439851003196	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851003197	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
439851003198	Paraquat-inducible protein A; Region: PqiA; pfam04403
439851003199	Paraquat-inducible protein A; Region: PqiA; pfam04403
439851003200	paraquat-inducible protein B; Provisional; Region: PRK10807
439851003201	mce related protein; Region: MCE; pfam02470
439851003202	mce related protein; Region: MCE; pfam02470
439851003203	mce related protein; Region: MCE; pfam02470
439851003204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
439851003205	Protein of unknown function (DUF330); Region: DUF330; pfam03886
439851003206	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
439851003207	active site 1 [active]
439851003208	dimer interface [polypeptide binding]; other site
439851003209	active site 2 [active]
439851003210	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
439851003211	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
439851003212	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
439851003213	outer membrane protein A; Reviewed; Region: PRK10808
439851003214	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
439851003215	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439851003216	ligand binding site [chemical binding]; other site
439851003217	cell division inhibitor SulA; Region: sula; TIGR00623
439851003218	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
439851003219	TfoX C-terminal domain; Region: TfoX_C; pfam04994
439851003220	TIGR01666 family membrane protein; Region: YCCS
439851003221	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
439851003222	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439851003223	Predicted membrane protein [Function unknown]; Region: COG3304
439851003224	Domain of unknown function (DUF307); Region: DUF307; pfam03733
439851003225	Domain of unknown function (DUF307); Region: DUF307; pfam03733
439851003226	DNA helicase IV; Provisional; Region: helD; PRK11054
439851003227	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
439851003228	Part of AAA domain; Region: AAA_19; pfam13245
439851003229	Family description; Region: UvrD_C_2; pfam13538
439851003230	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
439851003231	active site
439851003232	dimer interfaces [polypeptide binding]; other site
439851003233	catalytic residues [active]
439851003234	hypothetical protein; Provisional; Region: PRK03641
439851003235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
439851003236	heat shock protein HspQ; Provisional; Region: PRK14129
439851003237	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
439851003238	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
439851003239	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
439851003240	putative RNA binding site [nucleotide binding]; other site
439851003241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851003242	S-adenosylmethionine binding site [chemical binding]; other site
439851003243	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
439851003244	substrate binding site [chemical binding]; other site
439851003245	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851003246	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851003247	acylphosphatase; Provisional; Region: PRK14426
439851003248	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
439851003249	sulfur transfer protein TusE; Provisional; Region: PRK11508
439851003250	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439851003251	YccA-like proteins; Region: YccA_like; cd10433
439851003252	PipA protein; Region: PipA; pfam07108
439851003253	secreted effector protein PipB; Provisional; Region: PRK15197
439851003254	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851003255	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851003256	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851003257	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
439851003258	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
439851003259	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
439851003260	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
439851003261	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
439851003262	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
439851003263	HAMP domain; Region: HAMP; pfam00672
439851003264	dimerization interface [polypeptide binding]; other site
439851003265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851003266	dimer interface [polypeptide binding]; other site
439851003267	phosphorylation site [posttranslational modification]
439851003268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851003269	ATP binding site [chemical binding]; other site
439851003270	Mg2+ binding site [ion binding]; other site
439851003271	G-X-G motif; other site
439851003272	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
439851003273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851003274	active site
439851003275	phosphorylation site [posttranslational modification]
439851003276	intermolecular recognition site; other site
439851003277	dimerization interface [polypeptide binding]; other site
439851003278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851003279	DNA binding site [nucleotide binding]
439851003280	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
439851003281	active site
439851003282	homotetramer interface [polypeptide binding]; other site
439851003283	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
439851003284	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
439851003285	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
439851003286	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
439851003287	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
439851003288	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
439851003289	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
439851003290	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
439851003291	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
439851003292	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
439851003293	NAD binding site [chemical binding]; other site
439851003294	catalytic residues [active]
439851003295	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
439851003296	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
439851003297	putative active site [active]
439851003298	putative metal binding site [ion binding]; other site
439851003299	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
439851003300	putative substrate binding pocket [chemical binding]; other site
439851003301	trimer interface [polypeptide binding]; other site
439851003302	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
439851003303	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
439851003304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851003305	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
439851003306	putative substrate translocation pore; other site
439851003307	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
439851003308	Cupin domain; Region: Cupin_2; pfam07883
439851003309	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851003310	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
439851003311	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
439851003312	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
439851003313	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
439851003314	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
439851003315	HSP70 interaction site [polypeptide binding]; other site
439851003316	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
439851003317	substrate binding site [polypeptide binding]; other site
439851003318	dimer interface [polypeptide binding]; other site
439851003319	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
439851003320	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
439851003321	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
439851003322	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
439851003323	DsbD alpha interface [polypeptide binding]; other site
439851003324	catalytic residues [active]
439851003325	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
439851003326	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
439851003327	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439851003328	catalytic residues [active]
439851003329	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
439851003330	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
439851003331	catalytic residues [active]
439851003332	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
439851003333	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
439851003334	catalytic core [active]
439851003335	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
439851003336	hypothetical protein; Provisional; Region: PRK10174
439851003337	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
439851003338	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
439851003339	General stress protein [General function prediction only]; Region: GsiB; COG3729
439851003340	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
439851003341	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851003342	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
439851003343	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
439851003344	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
439851003345	Predicted transcriptional regulator [Transcription]; Region: COG3905
439851003346	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
439851003347	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
439851003348	Glutamate binding site [chemical binding]; other site
439851003349	NAD binding site [chemical binding]; other site
439851003350	catalytic residues [active]
439851003351	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
439851003352	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
439851003353	Na binding site [ion binding]; other site
439851003354	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
439851003355	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
439851003356	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
439851003357	putative active site [active]
439851003358	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
439851003359	Na binding site [ion binding]; other site
439851003360	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
439851003361	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
439851003362	putative active site cavity [active]
439851003363	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
439851003364	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
439851003365	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
439851003366	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
439851003367	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439851003368	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439851003369	YCII-related domain; Region: YCII; cl00999
439851003370	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851003371	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
439851003372	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
439851003373	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
439851003374	ImpA domain protein; Region: DUF3702; pfam12486
439851003375	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
439851003376	AAA domain; Region: AAA_17; pfam13207
439851003377	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
439851003378	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
439851003379	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
439851003380	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
439851003381	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
439851003382	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
439851003383	type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360
439851003384	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
439851003385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851003386	Walker A motif; other site
439851003387	ATP binding site [chemical binding]; other site
439851003388	Walker B motif; other site
439851003389	arginine finger; other site
439851003390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851003391	Walker A motif; other site
439851003392	ATP binding site [chemical binding]; other site
439851003393	Walker B motif; other site
439851003394	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
439851003395	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
439851003396	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
439851003397	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
439851003398	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
439851003399	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
439851003400	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
439851003401	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
439851003402	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
439851003403	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
439851003404	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
439851003405	Protein of unknown function (DUF877); Region: DUF877; pfam05943
439851003406	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
439851003407	Protein of unknown function (DUF770); Region: DUF770; pfam05591
439851003408	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
439851003409	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
439851003410	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
439851003411	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
439851003412	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
439851003413	PAAR motif; Region: PAAR_motif; cl15808
439851003414	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
439851003415	RHS Repeat; Region: RHS_repeat; pfam05593
439851003416	RHS Repeat; Region: RHS_repeat; pfam05593
439851003417	RHS Repeat; Region: RHS_repeat; pfam05593
439851003418	RHS Repeat; Region: RHS_repeat; cl11982
439851003419	RHS Repeat; Region: RHS_repeat; pfam05593
439851003420	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
439851003421	RHS Repeat; Region: RHS_repeat; pfam05593
439851003422	RHS Repeat; Region: RHS_repeat; pfam05593
439851003423	RHS Repeat; Region: RHS_repeat; cl11982
439851003424	RHS protein; Region: RHS; pfam03527
439851003425	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
439851003426	Transposase; Region: HTH_Tnp_1; cl17663
439851003427	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
439851003428	dsRNA-gated channel SID-1; Region: SID-1_RNA_chan; pfam13965
439851003429	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439851003430	DNA-binding site [nucleotide binding]; DNA binding site
439851003431	RNA-binding motif; other site
439851003432	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
439851003433	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851003434	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
439851003435	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439851003436	Zn2+ binding site [ion binding]; other site
439851003437	Mg2+ binding site [ion binding]; other site
439851003438	DNA cytosine methylase; Provisional; Region: PRK10458
439851003439	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
439851003440	cofactor binding site; other site
439851003441	DNA binding site [nucleotide binding]
439851003442	substrate interaction site [chemical binding]; other site
439851003443	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
439851003444	additional DNA contacts [nucleotide binding]; other site
439851003445	mismatch recognition site; other site
439851003446	active site
439851003447	zinc binding site [ion binding]; other site
439851003448	DNA intercalation site [nucleotide binding]; other site
439851003449	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
439851003450	EamA-like transporter family; Region: EamA; pfam00892
439851003451	EamA-like transporter family; Region: EamA; pfam00892
439851003452	hypothetical protein; Provisional; Region: PRK10062
439851003453	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
439851003454	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851003455	metal binding site [ion binding]; metal-binding site
439851003456	active site
439851003457	I-site; other site
439851003458	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
439851003459	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851003460	active site
439851003461	motif I; other site
439851003462	motif II; other site
439851003463	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
439851003464	hypothetical protein; Provisional; Region: PRK10708
439851003465	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
439851003466	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851003467	DNA binding residues [nucleotide binding]
439851003468	dimerization interface [polypeptide binding]; other site
439851003469	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
439851003470	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
439851003471	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
439851003472	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
439851003473	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
439851003474	flagellar motor switch protein; Validated; Region: fliN; PRK05698
439851003475	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
439851003476	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
439851003477	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
439851003478	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
439851003479	flagellar hook-length control protein; Provisional; Region: PRK10118
439851003480	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
439851003481	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
439851003482	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
439851003483	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
439851003484	Walker A motif/ATP binding site; other site
439851003485	Walker B motif; other site
439851003486	flagellar assembly protein H; Validated; Region: fliH; PRK05687
439851003487	Flagellar assembly protein FliH; Region: FliH; pfam02108
439851003488	flagellar motor switch protein FliG; Region: fliG; TIGR00207
439851003489	FliG C-terminal domain; Region: FliG_C; pfam01706
439851003490	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
439851003491	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
439851003492	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
439851003493	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
439851003494	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
439851003495	CPxP  motif; other site
439851003496	putative inner membrane protein; Provisional; Region: PRK11099
439851003497	Sulphur transport; Region: Sulf_transp; pfam04143
439851003498	lipoprotein; Provisional; Region: PRK10397
439851003499	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
439851003500	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
439851003501	active site
439851003502	Na/Ca binding site [ion binding]; other site
439851003503	catalytic site [active]
439851003504	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
439851003505	flagellar protein FliS; Validated; Region: fliS; PRK05685
439851003506	flagellar capping protein; Reviewed; Region: fliD; PRK08032
439851003507	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
439851003508	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
439851003509	flagellin; Validated; Region: PRK08026
439851003510	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
439851003511	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
439851003512	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
439851003513	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439851003514	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
439851003515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439851003516	DNA binding residues [nucleotide binding]
439851003517	cystine transporter subunit; Provisional; Region: PRK11260
439851003518	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851003519	substrate binding pocket [chemical binding]; other site
439851003520	membrane-bound complex binding site; other site
439851003521	hinge residues; other site
439851003522	D-cysteine desulfhydrase; Validated; Region: PRK03910
439851003523	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
439851003524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851003525	catalytic residue [active]
439851003526	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851003527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851003528	dimer interface [polypeptide binding]; other site
439851003529	conserved gate region; other site
439851003530	putative PBP binding loops; other site
439851003531	ABC-ATPase subunit interface; other site
439851003532	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
439851003533	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439851003534	Walker A/P-loop; other site
439851003535	ATP binding site [chemical binding]; other site
439851003536	Q-loop/lid; other site
439851003537	ABC transporter signature motif; other site
439851003538	Walker B; other site
439851003539	D-loop; other site
439851003540	H-loop/switch region; other site
439851003541	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439851003542	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
439851003543	Autoinducer binding domain; Region: Autoind_bind; pfam03472
439851003544	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851003545	DNA binding residues [nucleotide binding]
439851003546	dimerization interface [polypeptide binding]; other site
439851003547	hypothetical protein; Provisional; Region: PRK10613
439851003548	response regulator; Provisional; Region: PRK09483
439851003549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851003550	active site
439851003551	phosphorylation site [posttranslational modification]
439851003552	intermolecular recognition site; other site
439851003553	dimerization interface [polypeptide binding]; other site
439851003554	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851003555	DNA binding residues [nucleotide binding]
439851003556	dimerization interface [polypeptide binding]; other site
439851003557	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
439851003558	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
439851003559	GIY-YIG motif/motif A; other site
439851003560	active site
439851003561	catalytic site [active]
439851003562	putative DNA binding site [nucleotide binding]; other site
439851003563	metal binding site [ion binding]; metal-binding site
439851003564	UvrB/uvrC motif; Region: UVR; pfam02151
439851003565	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
439851003566	Helix-hairpin-helix motif; Region: HHH; pfam00633
439851003567	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
439851003568	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
439851003569	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
439851003570	NlpC/P60 family; Region: NLPC_P60; cl17555
439851003571	glucose-6-phosphate 1-dehydrogenase; Region: PLN02640
439851003572	hypothetical protein; Provisional; Region: PRK10396
439851003573	yecA family protein; Region: ygfB_yecA; TIGR02292
439851003574	SEC-C motif; Region: SEC-C; pfam02810
439851003575	tyrosine transporter TyrP; Provisional; Region: PRK15132
439851003576	aromatic amino acid transport protein; Region: araaP; TIGR00837
439851003577	probable metal-binding protein; Region: matur_matur; TIGR03853
439851003578	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
439851003579	Ferritin-like domain; Region: Ferritin; pfam00210
439851003580	ferroxidase diiron center [ion binding]; other site
439851003581	YecR-like lipoprotein; Region: YecR; pfam13992
439851003582	hypothetical protein; Provisional; Region: PRK09273
439851003583	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
439851003584	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
439851003585	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
439851003586	Ferritin-like domain; Region: Ferritin; pfam00210
439851003587	ferroxidase diiron center [ion binding]; other site
439851003588	DJ-1 family protein; Region: not_thiJ; TIGR01383
439851003589	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
439851003590	conserved cys residue [active]
439851003591	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
439851003592	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
439851003593	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
439851003594	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
439851003595	active site
439851003596	homotetramer interface [polypeptide binding]; other site
439851003597	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439851003598	Ligand Binding Site [chemical binding]; other site
439851003599	transcriptional activator FlhD; Provisional; Region: PRK02909
439851003600	transcriptional activator FlhC; Provisional; Region: PRK12722
439851003601	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
439851003602	flagellar motor protein MotA; Validated; Region: PRK09110
439851003603	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
439851003604	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
439851003605	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439851003606	ligand binding site [chemical binding]; other site
439851003607	chemotaxis protein CheA; Provisional; Region: PRK10547
439851003608	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439851003609	putative binding surface; other site
439851003610	active site
439851003611	CheY binding; Region: CheY-binding; pfam09078
439851003612	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
439851003613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851003614	ATP binding site [chemical binding]; other site
439851003615	Mg2+ binding site [ion binding]; other site
439851003616	G-X-G motif; other site
439851003617	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
439851003618	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
439851003619	putative CheA interaction surface; other site
439851003620	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
439851003621	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439851003622	dimer interface [polypeptide binding]; other site
439851003623	ligand binding site [chemical binding]; other site
439851003624	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851003625	dimerization interface [polypeptide binding]; other site
439851003626	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851003627	dimer interface [polypeptide binding]; other site
439851003628	putative CheW interface [polypeptide binding]; other site
439851003629	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
439851003630	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
439851003631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851003632	S-adenosylmethionine binding site [chemical binding]; other site
439851003633	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
439851003634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851003635	active site
439851003636	phosphorylation site [posttranslational modification]
439851003637	intermolecular recognition site; other site
439851003638	dimerization interface [polypeptide binding]; other site
439851003639	CheB methylesterase; Region: CheB_methylest; pfam01339
439851003640	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
439851003641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851003642	active site
439851003643	phosphorylation site [posttranslational modification]
439851003644	intermolecular recognition site; other site
439851003645	dimerization interface [polypeptide binding]; other site
439851003646	chemotaxis regulator CheZ; Provisional; Region: PRK11166
439851003647	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
439851003648	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
439851003649	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
439851003650	FHIPEP family; Region: FHIPEP; pfam00771
439851003651	Flagellar protein FlhE; Region: FlhE; pfam06366
439851003652	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
439851003653	penicillin-binding protein 2; Provisional; Region: PRK10795
439851003654	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439851003655	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439851003656	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
439851003657	arginyl-tRNA synthetase; Region: argS; TIGR00456
439851003658	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
439851003659	active site
439851003660	HIGH motif; other site
439851003661	KMSK motif region; other site
439851003662	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
439851003663	tRNA binding surface [nucleotide binding]; other site
439851003664	anticodon binding site; other site
439851003665	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
439851003666	putative metal binding site [ion binding]; other site
439851003667	copper homeostasis protein CutC; Provisional; Region: PRK11572
439851003668	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851003669	S-adenosylmethionine binding site [chemical binding]; other site
439851003670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851003671	S-adenosylmethionine binding site [chemical binding]; other site
439851003672	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
439851003673	hypothetical protein; Provisional; Region: PRK10302
439851003674	Isochorismatase family; Region: Isochorismatase; pfam00857
439851003675	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
439851003676	catalytic triad [active]
439851003677	conserved cis-peptide bond; other site
439851003678	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
439851003679	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
439851003680	dimer interface [polypeptide binding]; other site
439851003681	anticodon binding site; other site
439851003682	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
439851003683	homodimer interface [polypeptide binding]; other site
439851003684	motif 1; other site
439851003685	active site
439851003686	motif 2; other site
439851003687	GAD domain; Region: GAD; pfam02938
439851003688	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
439851003689	active site
439851003690	motif 3; other site
439851003691	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
439851003692	nudix motif; other site
439851003693	hypothetical protein; Validated; Region: PRK00110
439851003694	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
439851003695	active site
439851003696	putative DNA-binding cleft [nucleotide binding]; other site
439851003697	dimer interface [polypeptide binding]; other site
439851003698	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
439851003699	hypothetical protein; Provisional; Region: PRK11470
439851003700	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
439851003701	RuvA N terminal domain; Region: RuvA_N; pfam01330
439851003702	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
439851003703	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
439851003704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851003705	Walker A motif; other site
439851003706	ATP binding site [chemical binding]; other site
439851003707	Walker B motif; other site
439851003708	arginine finger; other site
439851003709	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
439851003710	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
439851003711	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851003712	ABC-ATPase subunit  interface; other site
439851003713	dimer interface [polypeptide binding]; other site
439851003714	putative PBP binding regions; other site
439851003715	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
439851003716	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
439851003717	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
439851003718	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
439851003719	metal binding site [ion binding]; metal-binding site
439851003720	putative peptidase; Provisional; Region: PRK11649
439851003721	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
439851003722	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851003723	Peptidase family M23; Region: Peptidase_M23; pfam01551
439851003724	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
439851003725	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
439851003726	putative acyl-acceptor binding pocket; other site
439851003727	pyruvate kinase; Provisional; Region: PRK05826
439851003728	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
439851003729	domain interfaces; other site
439851003730	active site
439851003731	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
439851003732	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
439851003733	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
439851003734	putative active site [active]
439851003735	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
439851003736	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
439851003737	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
439851003738	phosphogluconate dehydratase; Validated; Region: PRK09054
439851003739	6-phosphogluconate dehydratase; Region: edd; TIGR01196
439851003740	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
439851003741	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
439851003742	active site
439851003743	intersubunit interface [polypeptide binding]; other site
439851003744	catalytic residue [active]
439851003745	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
439851003746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
439851003747	ATP-grasp domain; Region: ATP-grasp; pfam02222
439851003748	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
439851003749	hypothetical protein; Provisional; Region: PRK13680
439851003750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
439851003751	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
439851003752	putative metal binding site [ion binding]; other site
439851003753	protease 2; Provisional; Region: PRK10115
439851003754	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
439851003755	exodeoxyribonuclease X; Provisional; Region: PRK07983
439851003756	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
439851003757	active site
439851003758	catalytic site [active]
439851003759	substrate binding site [chemical binding]; other site
439851003760	Predicted amidohydrolase [General function prediction only]; Region: COG0388
439851003761	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
439851003762	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
439851003763	hypothetical protein; Provisional; Region: PRK10301
439851003764	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
439851003765	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
439851003766	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
439851003767	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
439851003768	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
439851003769	dimer interface [polypeptide binding]; other site
439851003770	active site
439851003771	Int/Topo IB signature motif; other site
439851003772	hypothetical protein; Provisional; Region: PRK09750
439851003773	recombination and repair protein RecT; Reviewed; Region: recT; PRK09846
439851003774	exonuclease VIII; Reviewed; Region: PRK09709
439851003775	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
439851003776	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
439851003777	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
439851003778	transcriptional repressor DicA; Reviewed; Region: PRK09706
439851003779	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
439851003780	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
439851003781	primosomal protein DnaI; Provisional; Region: PRK02854
439851003782	Replication protein P; Region: Phage_lambda_P; pfam06992
439851003783	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439851003784	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851003785	metal binding site [ion binding]; metal-binding site
439851003786	active site
439851003787	I-site; other site
439851003788	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
439851003789	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
439851003790	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
439851003791	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
439851003792	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
439851003793	PipA protein; Region: PipA; pfam07108
439851003794	phage holin, lambda family; Region: holin_lambda; TIGR01594
439851003795	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
439851003796	catalytic residues [active]
439851003797	Bacteriophage lysis protein; Region: Phage_lysis; pfam03245
439851003798	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
439851003799	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
439851003800	Domain of unknown function (DUF1859); Region: DUF1859; pfam08948
439851003801	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
439851003802	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
439851003803	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
439851003804	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
439851003805	oligomer interface [polypeptide binding]; other site
439851003806	active site residues [active]
439851003807	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
439851003808	Uncharacterized conserved protein [Function unknown]; Region: COG5471
439851003809	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
439851003810	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
439851003811	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
439851003812	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
439851003813	phage minor tail protein G; Region: phage_lambda_G; TIGR01674
439851003814	Minor tail protein T; Region: Phage_tail_T; cl05636
439851003815	Phage-related minor tail protein [Function unknown]; Region: COG5281
439851003816	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
439851003817	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
439851003818	Phage-related protein [Function unknown]; Region: COG4718
439851003819	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
439851003820	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
439851003821	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
439851003822	E-class dimer interface [polypeptide binding]; other site
439851003823	P-class dimer interface [polypeptide binding]; other site
439851003824	active site
439851003825	Cu2+ binding site [ion binding]; other site
439851003826	Zn2+ binding site [ion binding]; other site
439851003827	Phage-related protein [Function unknown]; Region: gp18; COG4672
439851003828	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
439851003829	MPN+ (JAMM) motif; other site
439851003830	Zinc-binding site [ion binding]; other site
439851003831	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
439851003832	NlpC/P60 family; Region: NLPC_P60; cl17555
439851003833	Phage-related protein, tail component [Function unknown]; Region: COG4723
439851003834	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
439851003835	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
439851003836	Phage Tail Collar Domain; Region: Collar; pfam07484
439851003837	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439851003838	type III secretion protein SopE; Provisional; Region: PRK15279
439851003839	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
439851003840	SopE GEF domain; Region: SopE_GEF; pfam07487
439851003841	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
439851003842	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
439851003843	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
439851003844	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
439851003845	dimer interface [polypeptide binding]; other site
439851003846	active site
439851003847	Int/Topo IB signature motif; other site
439851003848	exonuclease VIII; Reviewed; Region: PRK09709
439851003849	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
439851003850	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
439851003851	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
439851003852	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
439851003853	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
439851003854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
439851003855	MULE transposase domain; Region: MULE; pfam10551
439851003856	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
439851003857	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
439851003858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851003859	Coenzyme A binding pocket [chemical binding]; other site
439851003860	type III secretion protein SopE2; Provisional; Region: PRK15280
439851003861	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
439851003862	SopE GEF domain; Region: SopE_GEF; pfam07487
439851003863	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
439851003864	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439851003865	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
439851003866	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
439851003867	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
439851003868	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
439851003869	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
439851003870	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
439851003871	mce related protein; Region: MCE; pfam02470
439851003872	mce related protein; Region: MCE; pfam02470
439851003873	mce related protein; Region: MCE; pfam02470
439851003874	mce related protein; Region: MCE; pfam02470
439851003875	mce related protein; Region: MCE; pfam02470
439851003876	mce related protein; Region: MCE; pfam02470
439851003877	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
439851003878	Paraquat-inducible protein A; Region: PqiA; pfam04403
439851003879	Paraquat-inducible protein A; Region: PqiA; pfam04403
439851003880	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
439851003881	GAF domain; Region: GAF_2; pfam13185
439851003882	ProP expression regulator; Provisional; Region: PRK04950
439851003883	ProQ/FINO family; Region: ProQ; pfam04352
439851003884	carboxy-terminal protease; Provisional; Region: PRK11186
439851003885	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
439851003886	protein binding site [polypeptide binding]; other site
439851003887	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
439851003888	Catalytic dyad [active]
439851003889	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
439851003890	heat shock protein HtpX; Provisional; Region: PRK05457
439851003891	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
439851003892	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439851003893	dimerization interface [polypeptide binding]; other site
439851003894	putative Zn2+ binding site [ion binding]; other site
439851003895	putative DNA binding site [nucleotide binding]; other site
439851003896	Bacterial transcriptional regulator; Region: IclR; pfam01614
439851003897	YobH-like protein; Region: YobH; pfam13996
439851003898	PhoPQ regulatory protein; Provisional; Region: PRK10299
439851003899	YebO-like protein; Region: YebO; pfam13974
439851003900	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439851003901	DNA-binding site [nucleotide binding]; DNA binding site
439851003902	RNA-binding motif; other site
439851003903	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
439851003904	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439851003905	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439851003906	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
439851003907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851003908	S-adenosylmethionine binding site [chemical binding]; other site
439851003909	hypothetical protein; Provisional; Region: PRK11469
439851003910	Domain of unknown function DUF; Region: DUF204; pfam02659
439851003911	Domain of unknown function DUF; Region: DUF204; pfam02659
439851003912	yybP-ykoY leader
439851003913	hypothetical protein; Provisional; Region: PRK02913
439851003914	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
439851003915	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
439851003916	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
439851003917	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439851003918	active pocket/dimerization site; other site
439851003919	active site
439851003920	phosphorylation site [posttranslational modification]
439851003921	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
439851003922	active site
439851003923	phosphorylation site [posttranslational modification]
439851003924	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
439851003925	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
439851003926	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439851003927	Transporter associated domain; Region: CorC_HlyC; smart01091
439851003928	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439851003929	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851003930	L-serine deaminase; Provisional; Region: PRK15023
439851003931	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439851003932	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439851003933	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
439851003934	putative active site [active]
439851003935	putative CoA binding site [chemical binding]; other site
439851003936	nudix motif; other site
439851003937	metal binding site [ion binding]; metal-binding site
439851003938	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
439851003939	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
439851003940	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
439851003941	hypothetical protein; Provisional; Region: PRK05114
439851003942	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
439851003943	homotrimer interaction site [polypeptide binding]; other site
439851003944	putative active site [active]
439851003945	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
439851003946	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
439851003947	DEAD_2; Region: DEAD_2; pfam06733
439851003948	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
439851003949	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
439851003950	Glycoprotease family; Region: Peptidase_M22; pfam00814
439851003951	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
439851003952	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
439851003953	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
439851003954	acyl-activating enzyme (AAE) consensus motif; other site
439851003955	putative AMP binding site [chemical binding]; other site
439851003956	putative active site [active]
439851003957	putative CoA binding site [chemical binding]; other site
439851003958	ribonuclease D; Provisional; Region: PRK10829
439851003959	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
439851003960	catalytic site [active]
439851003961	putative active site [active]
439851003962	putative substrate binding site [chemical binding]; other site
439851003963	HRDC domain; Region: HRDC; pfam00570
439851003964	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
439851003965	cell division inhibitor MinD; Provisional; Region: PRK10818
439851003966	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
439851003967	Switch I; other site
439851003968	Switch II; other site
439851003969	septum formation inhibitor; Reviewed; Region: minC; PRK03511
439851003970	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
439851003971	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
439851003972	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
439851003973	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
439851003974	hypothetical protein; Provisional; Region: PRK10691
439851003975	hypothetical protein; Provisional; Region: PRK05170
439851003976	GnsA/GnsB family; Region: GnsAB; pfam08178
439851003977	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
439851003978	disulfide bond formation protein B; Provisional; Region: PRK01749
439851003979	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
439851003980	transmembrane helices; other site
439851003981	fatty acid metabolism regulator; Provisional; Region: PRK04984
439851003982	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851003983	DNA-binding site [nucleotide binding]; DNA binding site
439851003984	FadR C-terminal domain; Region: FadR_C; pfam07840
439851003985	SpoVR family protein; Provisional; Region: PRK11767
439851003986	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
439851003987	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
439851003988	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
439851003989	alanine racemase; Reviewed; Region: dadX; PRK03646
439851003990	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
439851003991	active site
439851003992	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439851003993	substrate binding site [chemical binding]; other site
439851003994	catalytic residues [active]
439851003995	dimer interface [polypeptide binding]; other site
439851003996	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
439851003997	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
439851003998	TrkA-C domain; Region: TrkA_C; pfam02080
439851003999	Transporter associated domain; Region: CorC_HlyC; smart01091
439851004000	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
439851004001	dimer interface [polypeptide binding]; other site
439851004002	catalytic triad [active]
439851004003	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
439851004004	Flagellar regulator YcgR; Region: YcgR; pfam07317
439851004005	PilZ domain; Region: PilZ; pfam07238
439851004006	hypothetical protein; Provisional; Region: PRK10457
439851004007	trehalase; Provisional; Region: treA; PRK13271
439851004008	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
439851004009	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
439851004010	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
439851004011	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
439851004012	NAD(P) binding site [chemical binding]; other site
439851004013	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
439851004014	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
439851004015	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
439851004016	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
439851004017	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439851004018	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439851004019	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
439851004020	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
439851004021	putative substrate-binding site; other site
439851004022	nickel binding site [ion binding]; other site
439851004023	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
439851004024	hydrogenase 1 large subunit; Provisional; Region: PRK10170
439851004025	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
439851004026	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
439851004027	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
439851004028	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
439851004029	GTP-binding protein YchF; Reviewed; Region: PRK09601
439851004030	YchF GTPase; Region: YchF; cd01900
439851004031	G1 box; other site
439851004032	GTP/Mg2+ binding site [chemical binding]; other site
439851004033	Switch I region; other site
439851004034	G2 box; other site
439851004035	Switch II region; other site
439851004036	G3 box; other site
439851004037	G4 box; other site
439851004038	G5 box; other site
439851004039	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
439851004040	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
439851004041	putative active site [active]
439851004042	catalytic residue [active]
439851004043	hypothetical protein; Provisional; Region: PRK10692
439851004044	putative transporter; Provisional; Region: PRK11660
439851004045	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
439851004046	Sulfate transporter family; Region: Sulfate_transp; pfam00916
439851004047	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
439851004048	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
439851004049	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
439851004050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851004051	active site
439851004052	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
439851004053	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
439851004054	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
439851004055	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
439851004056	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
439851004057	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
439851004058	tRNA; other site
439851004059	putative tRNA binding site [nucleotide binding]; other site
439851004060	putative NADP binding site [chemical binding]; other site
439851004061	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
439851004062	peptide chain release factor 1; Validated; Region: prfA; PRK00591
439851004063	This domain is found in peptide chain release factors; Region: PCRF; smart00937
439851004064	RF-1 domain; Region: RF-1; pfam00472
439851004065	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
439851004066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851004067	hypothetical protein; Provisional; Region: PRK10278
439851004068	hypothetical protein; Provisional; Region: PRK10941
439851004069	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
439851004070	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
439851004071	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439851004072	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
439851004073	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
439851004074	cation transport regulator; Reviewed; Region: chaB; PRK09582
439851004075	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
439851004076	putative invasin; Provisional; Region: PRK10177
439851004077	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
439851004078	transcriptional regulator NarL; Provisional; Region: PRK10651
439851004079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851004080	active site
439851004081	phosphorylation site [posttranslational modification]
439851004082	intermolecular recognition site; other site
439851004083	dimerization interface [polypeptide binding]; other site
439851004084	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851004085	DNA binding residues [nucleotide binding]
439851004086	dimerization interface [polypeptide binding]; other site
439851004087	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
439851004088	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
439851004089	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851004090	dimerization interface [polypeptide binding]; other site
439851004091	Histidine kinase; Region: HisKA_3; pfam07730
439851004092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851004093	ATP binding site [chemical binding]; other site
439851004094	Mg2+ binding site [ion binding]; other site
439851004095	G-X-G motif; other site
439851004096	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
439851004097	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
439851004098	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
439851004099	[4Fe-4S] binding site [ion binding]; other site
439851004100	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439851004101	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439851004102	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439851004103	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
439851004104	molybdopterin cofactor binding site; other site
439851004105	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
439851004106	4Fe-4S binding domain; Region: Fer4; cl02805
439851004107	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
439851004108	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
439851004109	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851004110	Sel1-like repeats; Region: SEL1; smart00671
439851004111	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851004112	Sel1-like repeats; Region: SEL1; smart00671
439851004113	Sel1-like repeats; Region: SEL1; smart00671
439851004114	Sel1-like repeats; Region: SEL1; smart00671
439851004115	Sel1-like repeats; Region: SEL1; smart00671
439851004116	Sel1-like repeats; Region: SEL1; smart00671
439851004117	Sel1-like repeats; Region: SEL1; smart00671
439851004118	Sel1-like repeats; Region: SEL1; smart00671
439851004119	Sel1-like repeats; Region: SEL1; smart00671
439851004120	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
439851004121	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
439851004122	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
439851004123	putative active site [active]
439851004124	putative substrate binding site [chemical binding]; other site
439851004125	putative cosubstrate binding site; other site
439851004126	catalytic site [active]
439851004127	SEC-C motif; Region: SEC-C; pfam02810
439851004128	hypothetical protein; Provisional; Region: PRK04233
439851004129	hypothetical protein; Provisional; Region: PRK10279
439851004130	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
439851004131	active site
439851004132	nucleophile elbow; other site
439851004133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851004134	active site
439851004135	response regulator of RpoS; Provisional; Region: PRK10693
439851004136	phosphorylation site [posttranslational modification]
439851004137	intermolecular recognition site; other site
439851004138	dimerization interface [polypeptide binding]; other site
439851004139	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
439851004140	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
439851004141	active site
439851004142	tetramer interface; other site
439851004143	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
439851004144	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
439851004145	thymidine kinase; Provisional; Region: PRK04296
439851004146	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
439851004147	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
439851004148	putative catalytic cysteine [active]
439851004149	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
439851004150	putative active site [active]
439851004151	metal binding site [ion binding]; metal-binding site
439851004152	hypothetical protein; Provisional; Region: PRK11111
439851004153	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
439851004154	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
439851004155	peptide binding site [polypeptide binding]; other site
439851004156	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
439851004157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004158	dimer interface [polypeptide binding]; other site
439851004159	conserved gate region; other site
439851004160	putative PBP binding loops; other site
439851004161	ABC-ATPase subunit interface; other site
439851004162	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
439851004163	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439851004164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004165	dimer interface [polypeptide binding]; other site
439851004166	conserved gate region; other site
439851004167	ABC-ATPase subunit interface; other site
439851004168	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
439851004169	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851004170	Walker A/P-loop; other site
439851004171	ATP binding site [chemical binding]; other site
439851004172	Q-loop/lid; other site
439851004173	ABC transporter signature motif; other site
439851004174	Walker B; other site
439851004175	D-loop; other site
439851004176	H-loop/switch region; other site
439851004177	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439851004178	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
439851004179	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851004180	Walker A/P-loop; other site
439851004181	ATP binding site [chemical binding]; other site
439851004182	Q-loop/lid; other site
439851004183	ABC transporter signature motif; other site
439851004184	Walker B; other site
439851004185	D-loop; other site
439851004186	H-loop/switch region; other site
439851004187	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
439851004188	Ion transport protein; Region: Ion_trans; pfam00520
439851004189	Ion channel; Region: Ion_trans_2; pfam07885
439851004190	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
439851004191	Double zinc ribbon; Region: DZR; pfam12773
439851004192	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
439851004193	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
439851004194	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
439851004195	putative active site [active]
439851004196	catalytic site [active]
439851004197	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
439851004198	putative active site [active]
439851004199	catalytic site [active]
439851004200	YciI-like protein; Reviewed; Region: PRK11370
439851004201	transport protein TonB; Provisional; Region: PRK10819
439851004202	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
439851004203	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
439851004204	intracellular septation protein A; Reviewed; Region: PRK00259
439851004205	hypothetical protein; Provisional; Region: PRK02868
439851004206	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
439851004207	outer membrane protein W; Provisional; Region: PRK10959
439851004208	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
439851004209	dimanganese center [ion binding]; other site
439851004210	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
439851004211	dinuclear metal binding motif [ion binding]; other site
439851004212	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
439851004213	dimerization interface [polypeptide binding]; other site
439851004214	metal binding site [ion binding]; metal-binding site
439851004215	General stress protein [General function prediction only]; Region: GsiB; COG3729
439851004216	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
439851004217	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
439851004218	substrate binding site [chemical binding]; other site
439851004219	active site
439851004220	catalytic residues [active]
439851004221	heterodimer interface [polypeptide binding]; other site
439851004222	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
439851004223	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
439851004224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851004225	catalytic residue [active]
439851004226	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
439851004227	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
439851004228	active site
439851004229	ribulose/triose binding site [chemical binding]; other site
439851004230	phosphate binding site [ion binding]; other site
439851004231	substrate (anthranilate) binding pocket [chemical binding]; other site
439851004232	product (indole) binding pocket [chemical binding]; other site
439851004233	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
439851004234	active site
439851004235	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
439851004236	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
439851004237	glutamine binding [chemical binding]; other site
439851004238	catalytic triad [active]
439851004239	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
439851004240	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
439851004241	anthranilate synthase component I; Provisional; Region: PRK13564
439851004242	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
439851004243	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
439851004244	Tryptophan operon leader
439851004245	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
439851004246	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
439851004247	active site
439851004248	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
439851004249	hypothetical protein; Provisional; Region: PRK11630
439851004250	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
439851004251	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851004252	RNA binding surface [nucleotide binding]; other site
439851004253	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
439851004254	probable active site [active]
439851004255	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
439851004256	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
439851004257	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
439851004258	homodimer interface [polypeptide binding]; other site
439851004259	Walker A motif; other site
439851004260	ATP binding site [chemical binding]; other site
439851004261	hydroxycobalamin binding site [chemical binding]; other site
439851004262	Walker B motif; other site
439851004263	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
439851004264	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
439851004265	NADP binding site [chemical binding]; other site
439851004266	homodimer interface [polypeptide binding]; other site
439851004267	active site
439851004268	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
439851004269	putative inner membrane peptidase; Provisional; Region: PRK11778
439851004270	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
439851004271	tandem repeat interface [polypeptide binding]; other site
439851004272	oligomer interface [polypeptide binding]; other site
439851004273	active site residues [active]
439851004274	hypothetical protein; Provisional; Region: PRK11037
439851004275	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
439851004276	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
439851004277	active site
439851004278	interdomain interaction site; other site
439851004279	putative metal-binding site [ion binding]; other site
439851004280	nucleotide binding site [chemical binding]; other site
439851004281	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
439851004282	domain I; other site
439851004283	DNA binding groove [nucleotide binding]
439851004284	phosphate binding site [ion binding]; other site
439851004285	domain II; other site
439851004286	domain III; other site
439851004287	nucleotide binding site [chemical binding]; other site
439851004288	catalytic site [active]
439851004289	domain IV; other site
439851004290	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439851004291	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439851004292	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
439851004293	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
439851004294	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
439851004295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851004296	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
439851004297	substrate binding site [chemical binding]; other site
439851004298	putative dimerization interface [polypeptide binding]; other site
439851004299	aconitate hydratase; Validated; Region: PRK09277
439851004300	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
439851004301	substrate binding site [chemical binding]; other site
439851004302	ligand binding site [chemical binding]; other site
439851004303	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
439851004304	substrate binding site [chemical binding]; other site
439851004305	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
439851004306	dimerization interface [polypeptide binding]; other site
439851004307	active site
439851004308	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439851004309	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
439851004310	active site
439851004311	Predicted membrane protein [Function unknown]; Region: COG3771
439851004312	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
439851004313	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439851004314	binding surface
439851004315	TPR motif; other site
439851004316	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
439851004317	active site
439851004318	dimer interface [polypeptide binding]; other site
439851004319	translation initiation factor Sui1; Validated; Region: PRK06824
439851004320	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
439851004321	putative rRNA binding site [nucleotide binding]; other site
439851004322	lipoprotein; Provisional; Region: PRK10540
439851004323	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851004324	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851004325	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851004326	hypothetical protein; Provisional; Region: PRK13658
439851004327	RNase II stability modulator; Provisional; Region: PRK10060
439851004328	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439851004329	putative active site [active]
439851004330	heme pocket [chemical binding]; other site
439851004331	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851004332	metal binding site [ion binding]; metal-binding site
439851004333	active site
439851004334	I-site; other site
439851004335	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851004336	exoribonuclease II; Provisional; Region: PRK05054
439851004337	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
439851004338	RNB domain; Region: RNB; pfam00773
439851004339	S1 RNA binding domain; Region: S1; pfam00575
439851004340	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
439851004341	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
439851004342	NAD binding site [chemical binding]; other site
439851004343	homotetramer interface [polypeptide binding]; other site
439851004344	homodimer interface [polypeptide binding]; other site
439851004345	substrate binding site [chemical binding]; other site
439851004346	active site
439851004347	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
439851004348	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
439851004349	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
439851004350	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851004351	Walker A/P-loop; other site
439851004352	ATP binding site [chemical binding]; other site
439851004353	Q-loop/lid; other site
439851004354	ABC transporter signature motif; other site
439851004355	Walker B; other site
439851004356	D-loop; other site
439851004357	H-loop/switch region; other site
439851004358	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
439851004359	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851004360	Walker A/P-loop; other site
439851004361	ATP binding site [chemical binding]; other site
439851004362	Q-loop/lid; other site
439851004363	ABC transporter signature motif; other site
439851004364	Walker B; other site
439851004365	D-loop; other site
439851004366	H-loop/switch region; other site
439851004367	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439851004368	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
439851004369	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439851004370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004371	dimer interface [polypeptide binding]; other site
439851004372	conserved gate region; other site
439851004373	putative PBP binding loops; other site
439851004374	ABC-ATPase subunit interface; other site
439851004375	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
439851004376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004377	dimer interface [polypeptide binding]; other site
439851004378	conserved gate region; other site
439851004379	putative PBP binding loops; other site
439851004380	ABC-ATPase subunit interface; other site
439851004381	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
439851004382	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
439851004383	peptide binding site [polypeptide binding]; other site
439851004384	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
439851004385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851004386	Walker A motif; other site
439851004387	ATP binding site [chemical binding]; other site
439851004388	Walker B motif; other site
439851004389	arginine finger; other site
439851004390	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
439851004391	phage shock protein PspA; Provisional; Region: PRK10698
439851004392	phage shock protein B; Provisional; Region: pspB; PRK09458
439851004393	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
439851004394	phage shock protein C; Region: phageshock_pspC; TIGR02978
439851004395	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
439851004396	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
439851004397	active site residue [active]
439851004398	Predicted ATPase [General function prediction only]; Region: COG3106
439851004399	hypothetical protein; Provisional; Region: PRK05415
439851004400	TIGR01620 family protein; Region: hyp_HI0043
439851004401	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
439851004402	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
439851004403	putative aromatic amino acid binding site; other site
439851004404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851004405	Walker A motif; other site
439851004406	ATP binding site [chemical binding]; other site
439851004407	Walker B motif; other site
439851004408	arginine finger; other site
439851004409	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
439851004410	dimer interface [polypeptide binding]; other site
439851004411	catalytic triad [active]
439851004412	peroxidatic and resolving cysteines [active]
439851004413	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
439851004414	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
439851004415	active site
439851004416	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
439851004417	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
439851004418	putative active site [active]
439851004419	Zn binding site [ion binding]; other site
439851004420	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
439851004421	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
439851004422	peptide binding site [polypeptide binding]; other site
439851004423	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
439851004424	NmrA-like family; Region: NmrA; pfam05368
439851004425	NAD(P) binding site [chemical binding]; other site
439851004426	active site lysine
439851004427	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851004428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851004429	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
439851004430	putative effector binding pocket; other site
439851004431	putative dimerization interface [polypeptide binding]; other site
439851004432	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851004433	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851004434	active site
439851004435	catalytic tetrad [active]
439851004436	oxidoreductase; Provisional; Region: PRK12742
439851004437	classical (c) SDRs; Region: SDR_c; cd05233
439851004438	NAD(P) binding site [chemical binding]; other site
439851004439	active site
439851004440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439851004441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851004442	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439851004443	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
439851004444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851004445	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
439851004446	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
439851004447	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
439851004448	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
439851004449	B3/4 domain; Region: B3_4; pfam03483
439851004450	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
439851004451	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851004452	non-specific DNA binding site [nucleotide binding]; other site
439851004453	salt bridge; other site
439851004454	sequence-specific DNA binding site [nucleotide binding]; other site
439851004455	Cupin domain; Region: Cupin_2; pfam07883
439851004456	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
439851004457	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851004458	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
439851004459	universal stress protein UspE; Provisional; Region: PRK11175
439851004460	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439851004461	Ligand Binding Site [chemical binding]; other site
439851004462	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439851004463	Ligand Binding Site [chemical binding]; other site
439851004464	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
439851004465	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
439851004466	ligand binding site [chemical binding]; other site
439851004467	flexible hinge region; other site
439851004468	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
439851004469	putative switch regulator; other site
439851004470	non-specific DNA interactions [nucleotide binding]; other site
439851004471	DNA binding site [nucleotide binding]
439851004472	sequence specific DNA binding site [nucleotide binding]; other site
439851004473	putative cAMP binding site [chemical binding]; other site
439851004474	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
439851004475	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
439851004476	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
439851004477	DNA binding site [nucleotide binding]
439851004478	active site
439851004479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
439851004480	Smr domain; Region: Smr; pfam01713
439851004481	HAMP domain; Region: HAMP; pfam00672
439851004482	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
439851004483	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851004484	dimer interface [polypeptide binding]; other site
439851004485	putative CheW interface [polypeptide binding]; other site
439851004486	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
439851004487	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
439851004488	Cl binding site [ion binding]; other site
439851004489	oligomer interface [polypeptide binding]; other site
439851004490	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
439851004491	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439851004492	ATP binding site [chemical binding]; other site
439851004493	Mg++ binding site [ion binding]; other site
439851004494	motif III; other site
439851004495	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851004496	nucleotide binding region [chemical binding]; other site
439851004497	ATP-binding site [chemical binding]; other site
439851004498	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
439851004499	putative RNA binding site [nucleotide binding]; other site
439851004500	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
439851004501	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
439851004502	Ligand Binding Site [chemical binding]; other site
439851004503	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439851004504	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
439851004505	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439851004506	Ligand Binding Site [chemical binding]; other site
439851004507	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
439851004508	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
439851004509	dimer interface [polypeptide binding]; other site
439851004510	PYR/PP interface [polypeptide binding]; other site
439851004511	TPP binding site [chemical binding]; other site
439851004512	substrate binding site [chemical binding]; other site
439851004513	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
439851004514	Domain of unknown function; Region: EKR; smart00890
439851004515	4Fe-4S binding domain; Region: Fer4_6; pfam12837
439851004516	4Fe-4S binding domain; Region: Fer4; pfam00037
439851004517	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
439851004518	TPP-binding site [chemical binding]; other site
439851004519	dimer interface [polypeptide binding]; other site
439851004520	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
439851004521	Domain of unknown function (DUF333); Region: DUF333; pfam03891
439851004522	heat-inducible protein; Provisional; Region: PRK10449
439851004523	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
439851004524	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
439851004525	putative ligand binding site [chemical binding]; other site
439851004526	putative NAD binding site [chemical binding]; other site
439851004527	catalytic site [active]
439851004528	hypothetical protein; Provisional; Region: PRK10695
439851004529	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
439851004530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
439851004531	Uncharacterized conserved protein [Function unknown]; Region: COG3791
439851004532	azoreductase; Reviewed; Region: PRK00170
439851004533	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
439851004534	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
439851004535	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851004536	ATP binding site [chemical binding]; other site
439851004537	putative Mg++ binding site [ion binding]; other site
439851004538	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851004539	nucleotide binding region [chemical binding]; other site
439851004540	ATP-binding site [chemical binding]; other site
439851004541	Helicase associated domain (HA2); Region: HA2; pfam04408
439851004542	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
439851004543	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
439851004544	Uncharacterized conserved protein [Function unknown]; Region: COG1434
439851004545	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439851004546	putative active site [active]
439851004547	cytochrome b561; Provisional; Region: PRK11513
439851004548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851004549	S-adenosylmethionine binding site [chemical binding]; other site
439851004550	Predicted membrane protein [Function unknown]; Region: COG5305
439851004551	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851004552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004553	dimer interface [polypeptide binding]; other site
439851004554	conserved gate region; other site
439851004555	putative PBP binding loops; other site
439851004556	ABC-ATPase subunit interface; other site
439851004557	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
439851004558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851004559	Walker A/P-loop; other site
439851004560	ATP binding site [chemical binding]; other site
439851004561	Q-loop/lid; other site
439851004562	ABC transporter signature motif; other site
439851004563	Walker B; other site
439851004564	D-loop; other site
439851004565	H-loop/switch region; other site
439851004566	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851004567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004568	dimer interface [polypeptide binding]; other site
439851004569	conserved gate region; other site
439851004570	putative PBP binding loops; other site
439851004571	ABC-ATPase subunit interface; other site
439851004572	Predicted membrane protein [Function unknown]; Region: COG3326
439851004573	Sif protein; Region: Sif; cl11505
439851004574	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
439851004575	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
439851004576	active site
439851004577	catalytic triad [active]
439851004578	oxyanion hole [active]
439851004579	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
439851004580	putative metal binding site [ion binding]; other site
439851004581	putative homodimer interface [polypeptide binding]; other site
439851004582	putative homotetramer interface [polypeptide binding]; other site
439851004583	putative homodimer-homodimer interface [polypeptide binding]; other site
439851004584	putative allosteric switch controlling residues; other site
439851004585	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
439851004586	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
439851004587	substrate binding site [chemical binding]; other site
439851004588	catalytic Zn binding site [ion binding]; other site
439851004589	NAD binding site [chemical binding]; other site
439851004590	structural Zn binding site [ion binding]; other site
439851004591	dimer interface [polypeptide binding]; other site
439851004592	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439851004593	dimer interface [polypeptide binding]; other site
439851004594	ligand binding site [chemical binding]; other site
439851004595	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
439851004596	HAMP domain; Region: HAMP; pfam00672
439851004597	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851004598	dimer interface [polypeptide binding]; other site
439851004599	putative CheW interface [polypeptide binding]; other site
439851004600	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
439851004601	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851004602	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851004603	dimerization interface [polypeptide binding]; other site
439851004604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
439851004605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
439851004606	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
439851004607	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
439851004608	substrate binding pocket [chemical binding]; other site
439851004609	catalytic triad [active]
439851004610	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
439851004611	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
439851004612	Uncharacterized conserved protein [Function unknown]; Region: COG2353
439851004613	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
439851004614	teramer interface [polypeptide binding]; other site
439851004615	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
439851004616	active site
439851004617	FMN binding site [chemical binding]; other site
439851004618	catalytic residues [active]
439851004619	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851004620	Coenzyme A binding pocket [chemical binding]; other site
439851004621	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851004622	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439851004623	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851004624	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
439851004625	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
439851004626	substrate binding site [chemical binding]; other site
439851004627	hexamer interface [polypeptide binding]; other site
439851004628	metal binding site [ion binding]; metal-binding site
439851004629	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851004630	active site
439851004631	phosphorylation site [posttranslational modification]
439851004632	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
439851004633	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
439851004634	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
439851004635	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
439851004636	active site
439851004637	P-loop; other site
439851004638	phosphorylation site [posttranslational modification]
439851004639	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
439851004640	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
439851004641	oligomer interface [polypeptide binding]; other site
439851004642	active site
439851004643	metal binding site [ion binding]; metal-binding site
439851004644	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
439851004645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851004646	Coenzyme A binding pocket [chemical binding]; other site
439851004647	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
439851004648	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
439851004649	putative trimer interface [polypeptide binding]; other site
439851004650	putative CoA binding site [chemical binding]; other site
439851004651	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
439851004652	putative trimer interface [polypeptide binding]; other site
439851004653	putative CoA binding site [chemical binding]; other site
439851004654	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
439851004655	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
439851004656	gating phenylalanine in ion channel; other site
439851004657	tellurite resistance protein TehB; Provisional; Region: PRK11207
439851004658	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851004659	S-adenosylmethionine binding site [chemical binding]; other site
439851004660	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
439851004661	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
439851004662	benzoate transporter; Region: benE; TIGR00843
439851004663	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
439851004664	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851004665	non-specific DNA binding site [nucleotide binding]; other site
439851004666	salt bridge; other site
439851004667	sequence-specific DNA binding site [nucleotide binding]; other site
439851004668	Cupin domain; Region: Cupin_2; pfam07883
439851004669	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
439851004670	Peptidase family U32; Region: Peptidase_U32; pfam01136
439851004671	Collagenase; Region: DUF3656; pfam12392
439851004672	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
439851004673	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
439851004674	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
439851004675	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
439851004676	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851004677	DNA-binding site [nucleotide binding]; DNA binding site
439851004678	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851004679	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851004680	homodimer interface [polypeptide binding]; other site
439851004681	catalytic residue [active]
439851004682	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
439851004683	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
439851004684	tetrameric interface [polypeptide binding]; other site
439851004685	NAD binding site [chemical binding]; other site
439851004686	catalytic residues [active]
439851004687	substrate binding site [chemical binding]; other site
439851004688	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
439851004689	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
439851004690	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
439851004691	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
439851004692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
439851004693	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
439851004694	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
439851004695	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
439851004696	Prostaglandin dehydrogenases; Region: PGDH; cd05288
439851004697	NAD(P) binding site [chemical binding]; other site
439851004698	substrate binding site [chemical binding]; other site
439851004699	dimer interface [polypeptide binding]; other site
439851004700	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
439851004701	DNA-binding site [nucleotide binding]; DNA binding site
439851004702	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
439851004703	FCD domain; Region: FCD; pfam07729
439851004704	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
439851004705	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851004706	N-terminal plug; other site
439851004707	ligand-binding site [chemical binding]; other site
439851004708	Uncharacterized conserved protein [Function unknown]; Region: COG3391
439851004709	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
439851004710	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439851004711	L-asparagine permease; Provisional; Region: PRK15049
439851004712	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
439851004713	hypothetical protein; Provisional; Region: PRK10281
439851004714	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
439851004715	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
439851004716	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
439851004717	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
439851004718	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
439851004719	[4Fe-4S] binding site [ion binding]; other site
439851004720	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439851004721	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439851004722	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439851004723	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
439851004724	molybdopterin cofactor binding site; other site
439851004725	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
439851004726	TetR family transcriptional regulator; Provisional; Region: PRK14996
439851004727	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851004728	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
439851004729	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851004730	putative substrate translocation pore; other site
439851004731	Uncharacterized conserved protein [Function unknown]; Region: COG3791
439851004732	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851004733	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439851004734	trimer interface [polypeptide binding]; other site
439851004735	eyelet of channel; other site
439851004736	aromatic amino acid exporter; Provisional; Region: PRK11689
439851004737	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
439851004738	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
439851004739	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
439851004740	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
439851004741	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
439851004742	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
439851004743	NAD binding site [chemical binding]; other site
439851004744	substrate binding site [chemical binding]; other site
439851004745	catalytic Zn binding site [ion binding]; other site
439851004746	tetramer interface [polypeptide binding]; other site
439851004747	structural Zn binding site [ion binding]; other site
439851004748	malate dehydrogenase; Provisional; Region: PRK13529
439851004749	Malic enzyme, N-terminal domain; Region: malic; pfam00390
439851004750	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
439851004751	NAD(P) binding site [chemical binding]; other site
439851004752	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
439851004753	biofilm-dependent modulation protein; Provisional; Region: PRK11436
439851004754	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
439851004755	acid-resistance protein; Provisional; Region: hdeB; PRK11566
439851004756	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
439851004757	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
439851004758	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
439851004759	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
439851004760	catalytic site [active]
439851004761	active site
439851004762	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
439851004763	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
439851004764	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
439851004765	active site
439851004766	catalytic site [active]
439851004767	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
439851004768	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
439851004769	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
439851004770	active site
439851004771	catalytic site [active]
439851004772	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
439851004773	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851004774	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851004775	homodimer interface [polypeptide binding]; other site
439851004776	catalytic residue [active]
439851004777	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
439851004778	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439851004779	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851004780	DNA binding site [nucleotide binding]
439851004781	domain linker motif; other site
439851004782	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439851004783	dimerization interface (closed form) [polypeptide binding]; other site
439851004784	ligand binding site [chemical binding]; other site
439851004785	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
439851004786	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
439851004787	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
439851004788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851004789	D-galactonate transporter; Region: 2A0114; TIGR00893
439851004790	putative substrate translocation pore; other site
439851004791	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439851004792	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
439851004793	putative NAD(P) binding site [chemical binding]; other site
439851004794	catalytic Zn binding site [ion binding]; other site
439851004795	structural Zn binding site [ion binding]; other site
439851004796	Transcriptional regulators [Transcription]; Region: FadR; COG2186
439851004797	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851004798	DNA-binding site [nucleotide binding]; DNA binding site
439851004799	FCD domain; Region: FCD; pfam07729
439851004800	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
439851004801	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
439851004802	active site
439851004803	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
439851004804	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
439851004805	hydrogenase 1 large subunit; Provisional; Region: PRK10170
439851004806	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
439851004807	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
439851004808	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
439851004809	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
439851004810	putative substrate-binding site; other site
439851004811	nickel binding site [ion binding]; other site
439851004812	HupF/HypC family; Region: HupF_HypC; cl00394
439851004813	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
439851004814	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439851004815	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439851004816	Rubredoxin [Energy production and conversion]; Region: COG1773
439851004817	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
439851004818	iron binding site [ion binding]; other site
439851004819	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
439851004820	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
439851004821	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
439851004822	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851004823	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439851004824	trimer interface [polypeptide binding]; other site
439851004825	eyelet of channel; other site
439851004826	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
439851004827	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
439851004828	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
439851004829	glutaminase; Provisional; Region: PRK00971
439851004830	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
439851004831	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
439851004832	NAD(P) binding site [chemical binding]; other site
439851004833	catalytic residues [active]
439851004834	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851004835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851004836	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
439851004837	putative dimerization interface [polypeptide binding]; other site
439851004838	putative arabinose transporter; Provisional; Region: PRK03545
439851004839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851004840	putative substrate translocation pore; other site
439851004841	inner membrane protein; Provisional; Region: PRK10995
439851004842	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
439851004843	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
439851004844	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
439851004845	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851004846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851004847	MarB protein; Region: MarB; pfam13999
439851004848	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
439851004849	EamA-like transporter family; Region: EamA; pfam00892
439851004850	hypothetical protein; Provisional; Region: PRK10053
439851004851	hypothetical protein; Validated; Region: PRK03657
439851004852	General stress protein [General function prediction only]; Region: GsiB; COG3729
439851004853	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
439851004854	malonic semialdehyde reductase; Provisional; Region: PRK10538
439851004855	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
439851004856	putative NAD(P) binding site [chemical binding]; other site
439851004857	homodimer interface [polypeptide binding]; other site
439851004858	homotetramer interface [polypeptide binding]; other site
439851004859	active site
439851004860	Transcriptional regulators [Transcription]; Region: GntR; COG1802
439851004861	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851004862	DNA-binding site [nucleotide binding]; DNA binding site
439851004863	FCD domain; Region: FCD; pfam07729
439851004864	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
439851004865	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
439851004866	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
439851004867	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
439851004868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851004869	metabolite-proton symporter; Region: 2A0106; TIGR00883
439851004870	putative substrate translocation pore; other site
439851004871	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
439851004872	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
439851004873	putative active site pocket [active]
439851004874	putative metal binding site [ion binding]; other site
439851004875	hypothetical protein; Provisional; Region: PRK02237
439851004876	hypothetical protein; Provisional; Region: PRK13659
439851004877	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
439851004878	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851004879	Coenzyme A binding pocket [chemical binding]; other site
439851004880	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
439851004881	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
439851004882	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
439851004883	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439851004884	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439851004885	putative [Fe4-S4] binding site [ion binding]; other site
439851004886	putative molybdopterin cofactor binding site [chemical binding]; other site
439851004887	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439851004888	putative molybdopterin cofactor binding site; other site
439851004889	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439851004890	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439851004891	putative [Fe4-S4] binding site [ion binding]; other site
439851004892	putative molybdopterin cofactor binding site [chemical binding]; other site
439851004893	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439851004894	putative molybdopterin cofactor binding site; other site
439851004895	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439851004896	4Fe-4S binding domain; Region: Fer4; pfam00037
439851004897	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
439851004898	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
439851004899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004900	dimer interface [polypeptide binding]; other site
439851004901	conserved gate region; other site
439851004902	putative PBP binding loops; other site
439851004903	ABC-ATPase subunit interface; other site
439851004904	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
439851004905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851004906	dimer interface [polypeptide binding]; other site
439851004907	conserved gate region; other site
439851004908	ABC-ATPase subunit interface; other site
439851004909	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
439851004910	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
439851004911	Walker A/P-loop; other site
439851004912	ATP binding site [chemical binding]; other site
439851004913	Q-loop/lid; other site
439851004914	ABC transporter signature motif; other site
439851004915	Walker B; other site
439851004916	D-loop; other site
439851004917	H-loop/switch region; other site
439851004918	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
439851004919	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
439851004920	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
439851004921	Cl- selectivity filter; other site
439851004922	Cl- binding residues [ion binding]; other site
439851004923	pore gating glutamate residue; other site
439851004924	dimer interface [polypeptide binding]; other site
439851004925	putative dithiobiotin synthetase; Provisional; Region: PRK12374
439851004926	AAA domain; Region: AAA_26; pfam13500
439851004927	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
439851004928	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
439851004929	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851004930	nucleotide binding site [chemical binding]; other site
439851004931	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
439851004932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851004933	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
439851004934	dimerization interface [polypeptide binding]; other site
439851004935	substrate binding pocket [chemical binding]; other site
439851004936	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
439851004937	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851004938	putative substrate translocation pore; other site
439851004939	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
439851004940	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
439851004941	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
439851004942	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
439851004943	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439851004944	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
439851004945	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
439851004946	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
439851004947	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
439851004948	ligand binding site [chemical binding]; other site
439851004949	homodimer interface [polypeptide binding]; other site
439851004950	NAD(P) binding site [chemical binding]; other site
439851004951	trimer interface B [polypeptide binding]; other site
439851004952	trimer interface A [polypeptide binding]; other site
439851004953	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
439851004954	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851004955	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851004956	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851004957	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
439851004958	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851004959	active site
439851004960	phosphorylation site [posttranslational modification]
439851004961	intermolecular recognition site; other site
439851004962	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851004963	DNA binding site [nucleotide binding]
439851004964	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851004965	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439851004966	trimer interface [polypeptide binding]; other site
439851004967	eyelet of channel; other site
439851004968	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
439851004969	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
439851004970	active site
439851004971	sensor protein RstB; Provisional; Region: PRK10604
439851004972	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851004973	dimerization interface [polypeptide binding]; other site
439851004974	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851004975	dimer interface [polypeptide binding]; other site
439851004976	phosphorylation site [posttranslational modification]
439851004977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851004978	ATP binding site [chemical binding]; other site
439851004979	Mg2+ binding site [ion binding]; other site
439851004980	G-X-G motif; other site
439851004981	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
439851004982	fumarate hydratase; Reviewed; Region: fumC; PRK00485
439851004983	Class II fumarases; Region: Fumarase_classII; cd01362
439851004984	active site
439851004985	tetramer interface [polypeptide binding]; other site
439851004986	fumarate hydratase; Provisional; Region: PRK15389
439851004987	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
439851004988	Fumarase C-terminus; Region: Fumerase_C; pfam05683
439851004989	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
439851004990	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
439851004991	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
439851004992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
439851004993	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
439851004994	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
439851004995	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
439851004996	active site
439851004997	purine riboside binding site [chemical binding]; other site
439851004998	putative oxidoreductase; Provisional; Region: PRK11579
439851004999	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439851005000	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439851005001	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
439851005002	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
439851005003	electron transport complex protein RsxA; Provisional; Region: PRK05151
439851005004	electron transport complex protein RnfB; Provisional; Region: PRK05113
439851005005	Putative Fe-S cluster; Region: FeS; cl17515
439851005006	4Fe-4S binding domain; Region: Fer4; pfam00037
439851005007	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
439851005008	SLBB domain; Region: SLBB; pfam10531
439851005009	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439851005010	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
439851005011	electron transport complex protein RnfG; Validated; Region: PRK01908
439851005012	electron transport complex RsxE subunit; Provisional; Region: PRK12405
439851005013	endonuclease III; Provisional; Region: PRK10702
439851005014	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
439851005015	minor groove reading motif; other site
439851005016	helix-hairpin-helix signature motif; other site
439851005017	substrate binding pocket [chemical binding]; other site
439851005018	active site
439851005019	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
439851005020	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
439851005021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005022	putative substrate translocation pore; other site
439851005023	POT family; Region: PTR2; pfam00854
439851005024	glutathionine S-transferase; Provisional; Region: PRK10542
439851005025	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
439851005026	C-terminal domain interface [polypeptide binding]; other site
439851005027	GSH binding site (G-site) [chemical binding]; other site
439851005028	dimer interface [polypeptide binding]; other site
439851005029	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
439851005030	dimer interface [polypeptide binding]; other site
439851005031	N-terminal domain interface [polypeptide binding]; other site
439851005032	substrate binding pocket (H-site) [chemical binding]; other site
439851005033	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
439851005034	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
439851005035	active site
439851005036	HIGH motif; other site
439851005037	dimer interface [polypeptide binding]; other site
439851005038	KMSKS motif; other site
439851005039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851005040	RNA binding surface [nucleotide binding]; other site
439851005041	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
439851005042	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
439851005043	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
439851005044	lysozyme inhibitor; Provisional; Region: PRK11372
439851005045	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
439851005046	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
439851005047	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
439851005048	transcriptional regulator SlyA; Provisional; Region: PRK03573
439851005049	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
439851005050	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
439851005051	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
439851005052	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851005053	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851005054	Fusaric acid resistance protein family; Region: FUSC; pfam04632
439851005055	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439851005056	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
439851005057	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
439851005058	E-class dimer interface [polypeptide binding]; other site
439851005059	P-class dimer interface [polypeptide binding]; other site
439851005060	active site
439851005061	Cu2+ binding site [ion binding]; other site
439851005062	Zn2+ binding site [ion binding]; other site
439851005063	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851005064	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851005065	active site
439851005066	catalytic tetrad [active]
439851005067	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
439851005068	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439851005069	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851005070	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
439851005071	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
439851005072	FMN binding site [chemical binding]; other site
439851005073	active site
439851005074	substrate binding site [chemical binding]; other site
439851005075	catalytic residue [active]
439851005076	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
439851005077	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
439851005078	dimer interface [polypeptide binding]; other site
439851005079	active site
439851005080	metal binding site [ion binding]; metal-binding site
439851005081	glutathione binding site [chemical binding]; other site
439851005082	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
439851005083	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
439851005084	dimer interface [polypeptide binding]; other site
439851005085	catalytic site [active]
439851005086	putative active site [active]
439851005087	putative substrate binding site [chemical binding]; other site
439851005088	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
439851005089	putative GSH binding site [chemical binding]; other site
439851005090	catalytic residues [active]
439851005091	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
439851005092	NlpC/P60 family; Region: NLPC_P60; pfam00877
439851005093	superoxide dismutase; Provisional; Region: PRK10543
439851005094	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
439851005095	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
439851005096	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
439851005097	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851005098	DNA binding site [nucleotide binding]
439851005099	domain linker motif; other site
439851005100	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
439851005101	dimerization interface [polypeptide binding]; other site
439851005102	ligand binding site [chemical binding]; other site
439851005103	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
439851005104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851005105	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851005106	dimerization interface [polypeptide binding]; other site
439851005107	putative transporter; Provisional; Region: PRK11043
439851005108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005109	putative substrate translocation pore; other site
439851005110	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
439851005111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851005112	S-adenosylmethionine binding site [chemical binding]; other site
439851005113	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
439851005114	Lumazine binding domain; Region: Lum_binding; pfam00677
439851005115	Lumazine binding domain; Region: Lum_binding; pfam00677
439851005116	multidrug efflux protein; Reviewed; Region: PRK01766
439851005117	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
439851005118	cation binding site [ion binding]; other site
439851005119	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
439851005120	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
439851005121	type III secretion system protein SsaT; Provisional; Region: PRK15349
439851005122	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
439851005123	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
439851005124	type III secretion system protein SsaQ; Validated; Region: PRK08035
439851005125	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
439851005126	type III secretion system protein SsaP; Provisional; Region: PRK15351
439851005127	type III secretion system protein SsaO; Provisional; Region: PRK15352
439851005128	type III secretion system ATPase SsaN; Validated; Region: PRK07594
439851005129	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
439851005130	Walker A motif; other site
439851005131	ATP binding site [chemical binding]; other site
439851005132	Walker B motif; other site
439851005133	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
439851005134	FHIPEP family; Region: FHIPEP; pfam00771
439851005135	type III secretion system protein SsaM; Provisional; Region: PRK15353
439851005136	type III secretion system protein SsaL; Provisional; Region: PRK15345
439851005137	HrpJ-like domain; Region: HrpJ; pfam07201
439851005138	TyeA; Region: TyeA; cl07611
439851005139	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
439851005140	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
439851005141	type III secretion system protein SsaI; Provisional; Region: PRK15355
439851005142	type III secretion system protein SsaH; Provisional; Region: PRK15356
439851005143	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
439851005144	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
439851005145	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
439851005146	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
439851005147	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439851005148	TPR motif; other site
439851005149	binding surface
439851005150	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
439851005151	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
439851005152	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
439851005153	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
439851005154	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
439851005155	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
439851005156	type III secretion system protein SsaD; Provisional; Region: PRK15367
439851005157	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
439851005158	outer membrane secretin SsaC; Provisional; Region: PRK15346
439851005159	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
439851005160	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
439851005161	two component system sensor kinase SsrA; Provisional; Region: PRK15347
439851005162	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851005163	dimerization interface [polypeptide binding]; other site
439851005164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851005165	dimer interface [polypeptide binding]; other site
439851005166	phosphorylation site [posttranslational modification]
439851005167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851005168	ATP binding site [chemical binding]; other site
439851005169	Mg2+ binding site [ion binding]; other site
439851005170	G-X-G motif; other site
439851005171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851005172	active site
439851005173	phosphorylation site [posttranslational modification]
439851005174	intermolecular recognition site; other site
439851005175	dimerization interface [polypeptide binding]; other site
439851005176	two component system sensor kinase SsrB; Provisional; Region: PRK15369
439851005177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851005178	active site
439851005179	phosphorylation site [posttranslational modification]
439851005180	intermolecular recognition site; other site
439851005181	dimerization interface [polypeptide binding]; other site
439851005182	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851005183	DNA binding residues [nucleotide binding]
439851005184	dimerization interface [polypeptide binding]; other site
439851005185	Uncharacterized conserved protein [Function unknown]; Region: COG1683
439851005186	Uncharacterized conserved protein [Function unknown]; Region: COG3272
439851005187	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
439851005188	hypothetical protein; Provisional; Region: PRK10292
439851005189	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
439851005190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851005191	active site
439851005192	phosphorylation site [posttranslational modification]
439851005193	intermolecular recognition site; other site
439851005194	dimerization interface [polypeptide binding]; other site
439851005195	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851005196	DNA binding residues [nucleotide binding]
439851005197	dimerization interface [polypeptide binding]; other site
439851005198	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
439851005199	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
439851005200	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
439851005201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851005202	dimer interface [polypeptide binding]; other site
439851005203	phosphorylation site [posttranslational modification]
439851005204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851005205	ATP binding site [chemical binding]; other site
439851005206	Mg2+ binding site [ion binding]; other site
439851005207	G-X-G motif; other site
439851005208	tetrathionate reductase subunit B; Provisional; Region: PRK14993
439851005209	4Fe-4S binding domain; Region: Fer4; pfam00037
439851005210	tetrathionate reductase subunit C; Provisional; Region: PRK14992
439851005211	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
439851005212	tetrathionate reductase subunit A; Provisional; Region: PRK14991
439851005213	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
439851005214	putative [Fe4-S4] binding site [ion binding]; other site
439851005215	putative molybdopterin cofactor binding site [chemical binding]; other site
439851005216	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
439851005217	putative molybdopterin cofactor binding site; other site
439851005218	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851005219	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851005220	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851005221	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439851005222	substrate binding site [chemical binding]; other site
439851005223	dimer interface [polypeptide binding]; other site
439851005224	ATP binding site [chemical binding]; other site
439851005225	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
439851005226	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
439851005227	pyruvate kinase; Provisional; Region: PRK09206
439851005228	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
439851005229	domain interfaces; other site
439851005230	active site
439851005231	murein lipoprotein; Provisional; Region: PRK15396
439851005232	murein lipoprotein; Provisional; Region: PRK15396
439851005233	L,D-transpeptidase; Provisional; Region: PRK10190
439851005234	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851005235	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439851005236	cysteine desufuration protein SufE; Provisional; Region: PRK09296
439851005237	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
439851005238	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
439851005239	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851005240	catalytic residue [active]
439851005241	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
439851005242	FeS assembly protein SufD; Region: sufD; TIGR01981
439851005243	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
439851005244	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
439851005245	Walker A/P-loop; other site
439851005246	ATP binding site [chemical binding]; other site
439851005247	Q-loop/lid; other site
439851005248	ABC transporter signature motif; other site
439851005249	Walker B; other site
439851005250	D-loop; other site
439851005251	H-loop/switch region; other site
439851005252	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
439851005253	putative ABC transporter; Region: ycf24; CHL00085
439851005254	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
439851005255	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
439851005256	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439851005257	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
439851005258	CoenzymeA binding site [chemical binding]; other site
439851005259	subunit interaction site [polypeptide binding]; other site
439851005260	PHB binding site; other site
439851005261	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
439851005262	FAD binding domain; Region: FAD_binding_4; pfam01565
439851005263	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
439851005264	putative inner membrane protein; Provisional; Region: PRK10983
439851005265	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439851005266	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
439851005267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005268	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851005269	putative substrate translocation pore; other site
439851005270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005271	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851005272	putative substrate translocation pore; other site
439851005273	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
439851005274	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
439851005275	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
439851005276	shikimate binding site; other site
439851005277	NAD(P) binding site [chemical binding]; other site
439851005278	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
439851005279	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
439851005280	active site
439851005281	catalytic residue [active]
439851005282	dimer interface [polypeptide binding]; other site
439851005283	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
439851005284	Coenzyme A transferase; Region: CoA_trans; smart00882
439851005285	Coenzyme A transferase; Region: CoA_trans; cl17247
439851005286	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
439851005287	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
439851005288	active site
439851005289	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851005290	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851005291	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
439851005292	Ligand binding site [chemical binding]; other site
439851005293	Electron transfer flavoprotein domain; Region: ETF; pfam01012
439851005294	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
439851005295	Electron transfer flavoprotein domain; Region: ETF; smart00893
439851005296	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
439851005297	oxidoreductase; Provisional; Region: PRK10015
439851005298	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
439851005299	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
439851005300	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
439851005301	acyl-activating enzyme (AAE) consensus motif; other site
439851005302	putative AMP binding site [chemical binding]; other site
439851005303	putative active site [active]
439851005304	putative CoA binding site [chemical binding]; other site
439851005305	phosphoenolpyruvate synthase; Validated; Region: PRK06464
439851005306	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
439851005307	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
439851005308	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
439851005309	PEP synthetase regulatory protein; Provisional; Region: PRK05339
439851005310	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
439851005311	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439851005312	Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256
439851005313	Uncharacterized conserved protein [Function unknown]; Region: COG0397
439851005314	hypothetical protein; Validated; Region: PRK00029
439851005315	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
439851005316	NlpC/P60 family; Region: NLPC_P60; pfam00877
439851005317	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
439851005318	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439851005319	Walker A/P-loop; other site
439851005320	ATP binding site [chemical binding]; other site
439851005321	Q-loop/lid; other site
439851005322	ABC transporter signature motif; other site
439851005323	Walker B; other site
439851005324	D-loop; other site
439851005325	H-loop/switch region; other site
439851005326	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
439851005327	catalytic residues [active]
439851005328	dimer interface [polypeptide binding]; other site
439851005329	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439851005330	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851005331	ABC-ATPase subunit  interface; other site
439851005332	dimer interface [polypeptide binding]; other site
439851005333	putative PBP binding regions; other site
439851005334	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439851005335	IHF dimer interface [polypeptide binding]; other site
439851005336	IHF - DNA interface [nucleotide binding]; other site
439851005337	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
439851005338	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
439851005339	putative tRNA-binding site [nucleotide binding]; other site
439851005340	B3/4 domain; Region: B3_4; pfam03483
439851005341	tRNA synthetase B5 domain; Region: B5; smart00874
439851005342	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
439851005343	dimer interface [polypeptide binding]; other site
439851005344	motif 1; other site
439851005345	motif 3; other site
439851005346	motif 2; other site
439851005347	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
439851005348	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
439851005349	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
439851005350	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
439851005351	dimer interface [polypeptide binding]; other site
439851005352	motif 1; other site
439851005353	active site
439851005354	motif 2; other site
439851005355	motif 3; other site
439851005356	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
439851005357	23S rRNA binding site [nucleotide binding]; other site
439851005358	L21 binding site [polypeptide binding]; other site
439851005359	L13 binding site [polypeptide binding]; other site
439851005360	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
439851005361	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
439851005362	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
439851005363	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
439851005364	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
439851005365	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
439851005366	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
439851005367	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
439851005368	active site
439851005369	dimer interface [polypeptide binding]; other site
439851005370	motif 1; other site
439851005371	motif 2; other site
439851005372	motif 3; other site
439851005373	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
439851005374	anticodon binding site; other site
439851005375	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
439851005376	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
439851005377	active site
439851005378	substrate binding site [chemical binding]; other site
439851005379	Mg2+ binding site [ion binding]; other site
439851005380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
439851005381	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
439851005382	6-phosphofructokinase 2; Provisional; Region: PRK10294
439851005383	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
439851005384	putative substrate binding site [chemical binding]; other site
439851005385	putative ATP binding site [chemical binding]; other site
439851005386	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
439851005387	Phosphotransferase enzyme family; Region: APH; pfam01636
439851005388	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
439851005389	active site
439851005390	ATP binding site [chemical binding]; other site
439851005391	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
439851005392	YniB-like protein; Region: YniB; pfam14002
439851005393	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
439851005394	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
439851005395	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851005396	motif II; other site
439851005397	inner membrane protein; Provisional; Region: PRK11648
439851005398	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
439851005399	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439851005400	cell division modulator; Provisional; Region: PRK10113
439851005401	hydroperoxidase II; Provisional; Region: katE; PRK11249
439851005402	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
439851005403	tetramer interface [polypeptide binding]; other site
439851005404	heme binding pocket [chemical binding]; other site
439851005405	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
439851005406	domain interactions; other site
439851005407	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
439851005408	putative active site [active]
439851005409	YdjC motif; other site
439851005410	Mg binding site [ion binding]; other site
439851005411	putative homodimer interface [polypeptide binding]; other site
439851005412	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
439851005413	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
439851005414	NAD binding site [chemical binding]; other site
439851005415	sugar binding site [chemical binding]; other site
439851005416	divalent metal binding site [ion binding]; other site
439851005417	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439851005418	dimer interface [polypeptide binding]; other site
439851005419	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
439851005420	Cupin domain; Region: Cupin_2; pfam07883
439851005421	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851005422	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
439851005423	methionine cluster; other site
439851005424	active site
439851005425	phosphorylation site [posttranslational modification]
439851005426	metal binding site [ion binding]; metal-binding site
439851005427	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
439851005428	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
439851005429	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
439851005430	active site
439851005431	P-loop; other site
439851005432	phosphorylation site [posttranslational modification]
439851005433	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
439851005434	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
439851005435	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
439851005436	homodimer interface [polypeptide binding]; other site
439851005437	NAD binding pocket [chemical binding]; other site
439851005438	ATP binding pocket [chemical binding]; other site
439851005439	Mg binding site [ion binding]; other site
439851005440	active-site loop [active]
439851005441	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
439851005442	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
439851005443	GIY-YIG motif/motif A; other site
439851005444	active site
439851005445	catalytic site [active]
439851005446	putative DNA binding site [nucleotide binding]; other site
439851005447	metal binding site [ion binding]; metal-binding site
439851005448	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439851005449	dimer interface [polypeptide binding]; other site
439851005450	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
439851005451	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
439851005452	putative active site [active]
439851005453	Zn binding site [ion binding]; other site
439851005454	succinylarginine dihydrolase; Provisional; Region: PRK13281
439851005455	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
439851005456	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
439851005457	NAD(P) binding site [chemical binding]; other site
439851005458	catalytic residues [active]
439851005459	arginine succinyltransferase; Provisional; Region: PRK10456
439851005460	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
439851005461	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
439851005462	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439851005463	inhibitor-cofactor binding pocket; inhibition site
439851005464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851005465	catalytic residue [active]
439851005466	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
439851005467	putative catalytic site [active]
439851005468	putative phosphate binding site [ion binding]; other site
439851005469	active site
439851005470	metal binding site A [ion binding]; metal-binding site
439851005471	DNA binding site [nucleotide binding]
439851005472	putative AP binding site [nucleotide binding]; other site
439851005473	putative metal binding site B [ion binding]; other site
439851005474	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
439851005475	active site
439851005476	8-oxo-dGMP binding site [chemical binding]; other site
439851005477	nudix motif; other site
439851005478	metal binding site [ion binding]; metal-binding site
439851005479	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
439851005480	glutamate dehydrogenase; Provisional; Region: PRK09414
439851005481	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
439851005482	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
439851005483	NAD(P) binding site [chemical binding]; other site
439851005484	DNA topoisomerase III; Provisional; Region: PRK07726
439851005485	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
439851005486	active site
439851005487	putative interdomain interaction site [polypeptide binding]; other site
439851005488	putative metal-binding site [ion binding]; other site
439851005489	putative nucleotide binding site [chemical binding]; other site
439851005490	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
439851005491	domain I; other site
439851005492	DNA binding groove [nucleotide binding]
439851005493	phosphate binding site [ion binding]; other site
439851005494	domain II; other site
439851005495	domain III; other site
439851005496	nucleotide binding site [chemical binding]; other site
439851005497	catalytic site [active]
439851005498	domain IV; other site
439851005499	selenophosphate synthetase; Provisional; Region: PRK00943
439851005500	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
439851005501	dimerization interface [polypeptide binding]; other site
439851005502	putative ATP binding site [chemical binding]; other site
439851005503	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
439851005504	putative FMN binding site [chemical binding]; other site
439851005505	protease 4; Provisional; Region: PRK10949
439851005506	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
439851005507	tandem repeat interface [polypeptide binding]; other site
439851005508	oligomer interface [polypeptide binding]; other site
439851005509	active site residues [active]
439851005510	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
439851005511	tandem repeat interface [polypeptide binding]; other site
439851005512	oligomer interface [polypeptide binding]; other site
439851005513	active site residues [active]
439851005514	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
439851005515	active site
439851005516	homodimer interface [polypeptide binding]; other site
439851005517	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
439851005518	Isochorismatase family; Region: Isochorismatase; pfam00857
439851005519	catalytic triad [active]
439851005520	metal binding site [ion binding]; metal-binding site
439851005521	conserved cis-peptide bond; other site
439851005522	benzoate transport; Region: 2A0115; TIGR00895
439851005523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005524	putative substrate translocation pore; other site
439851005525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005526	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851005527	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851005528	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851005529	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851005530	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851005531	active site
439851005532	catalytic tetrad [active]
439851005533	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
439851005534	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851005535	substrate binding site [chemical binding]; other site
439851005536	ATP binding site [chemical binding]; other site
439851005537	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
439851005538	intersubunit interface [polypeptide binding]; other site
439851005539	active site
439851005540	zinc binding site [ion binding]; other site
439851005541	Na+ binding site [ion binding]; other site
439851005542	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
439851005543	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439851005544	inhibitor binding site; inhibition site
439851005545	catalytic Zn binding site [ion binding]; other site
439851005546	structural Zn binding site [ion binding]; other site
439851005547	NADP binding site [chemical binding]; other site
439851005548	tetramer interface [polypeptide binding]; other site
439851005549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005551	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439851005552	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
439851005553	putative NAD(P) binding site [chemical binding]; other site
439851005554	catalytic Zn binding site [ion binding]; other site
439851005555	structural Zn binding site [ion binding]; other site
439851005556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
439851005557	methionine sulfoxide reductase B; Provisional; Region: PRK00222
439851005558	SelR domain; Region: SelR; pfam01641
439851005559	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
439851005560	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
439851005561	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
439851005562	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
439851005563	active site
439851005564	phosphate binding residues; other site
439851005565	catalytic residues [active]
439851005566	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851005567	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851005568	active site
439851005569	catalytic tetrad [active]
439851005570	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439851005571	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851005572	FeS/SAM binding site; other site
439851005573	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439851005574	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
439851005575	PrkA family serine protein kinase; Provisional; Region: PRK15455
439851005576	AAA ATPase domain; Region: AAA_16; pfam13191
439851005577	Walker A motif; other site
439851005578	ATP binding site [chemical binding]; other site
439851005579	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
439851005580	hypothetical protein; Provisional; Region: PRK05325
439851005581	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439851005582	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851005583	metal binding site [ion binding]; metal-binding site
439851005584	active site
439851005585	I-site; other site
439851005586	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
439851005587	putative deacylase active site [active]
439851005588	Predicted membrane protein [Function unknown]; Region: COG2707
439851005589	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
439851005590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005591	Uncharacterized conserved protein [Function unknown]; Region: COG3189
439851005592	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
439851005593	murein hydrolase B; Provisional; Region: PRK10760; cl17906
439851005594	Domain of unknown function (DUF333); Region: DUF333; pfam03891
439851005595	hypothetical protein; Provisional; Region: PRK10457
439851005596	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
439851005597	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
439851005598	leucine export protein LeuE; Provisional; Region: PRK10958
439851005599	chorismate mutase; Provisional; Region: PRK08055
439851005600	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
439851005601	transcriptional regulator MirA; Provisional; Region: PRK15043
439851005602	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
439851005603	DNA binding residues [nucleotide binding]
439851005604	dimer interface [polypeptide binding]; other site
439851005605	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
439851005606	DNA binding residues [nucleotide binding]
439851005607	zinc/cadmium-binding protein; Provisional; Region: PRK10306
439851005608	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
439851005609	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851005610	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851005611	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
439851005612	Walker A/P-loop; other site
439851005613	ATP binding site [chemical binding]; other site
439851005614	Q-loop/lid; other site
439851005615	ABC transporter signature motif; other site
439851005616	Walker B; other site
439851005617	D-loop; other site
439851005618	H-loop/switch region; other site
439851005619	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851005620	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
439851005621	Walker A/P-loop; other site
439851005622	ATP binding site [chemical binding]; other site
439851005623	Q-loop/lid; other site
439851005624	ABC transporter signature motif; other site
439851005625	Walker B; other site
439851005626	D-loop; other site
439851005627	H-loop/switch region; other site
439851005628	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
439851005629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851005630	dimer interface [polypeptide binding]; other site
439851005631	conserved gate region; other site
439851005632	putative PBP binding loops; other site
439851005633	ABC-ATPase subunit interface; other site
439851005634	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
439851005635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851005636	dimer interface [polypeptide binding]; other site
439851005637	conserved gate region; other site
439851005638	ABC-ATPase subunit interface; other site
439851005639	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
439851005640	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
439851005641	TRL-like protein family; Region: TRL; pfam13146
439851005642	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
439851005643	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
439851005644	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
439851005645	putative dimer interface [polypeptide binding]; other site
439851005646	lysozyme inhibitor; Provisional; Region: PRK13791
439851005647	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
439851005648	Ricin-type beta-trefoil; Region: RICIN; smart00458
439851005649	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
439851005650	putative sugar binding sites [chemical binding]; other site
439851005651	Q-X-W motif; other site
439851005652	DinI-like family; Region: DinI; pfam06183
439851005653	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
439851005654	isocitrate dehydrogenase; Validated; Region: PRK07362
439851005655	isocitrate dehydrogenase; Reviewed; Region: PRK07006
439851005656	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
439851005657	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
439851005658	probable active site [active]
439851005659	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
439851005660	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
439851005661	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
439851005662	nudix motif; other site
439851005663	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
439851005664	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
439851005665	putative lysogenization regulator; Reviewed; Region: PRK00218
439851005666	adenylosuccinate lyase; Provisional; Region: PRK09285
439851005667	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
439851005668	tetramer interface [polypeptide binding]; other site
439851005669	active site
439851005670	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
439851005671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851005672	active site
439851005673	phosphorylation site [posttranslational modification]
439851005674	intermolecular recognition site; other site
439851005675	dimerization interface [polypeptide binding]; other site
439851005676	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851005677	DNA binding site [nucleotide binding]
439851005678	sensor protein PhoQ; Provisional; Region: PRK10815
439851005679	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
439851005680	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
439851005681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851005682	ATP binding site [chemical binding]; other site
439851005683	Mg2+ binding site [ion binding]; other site
439851005684	G-X-G motif; other site
439851005685	Uncharacterized conserved protein [Function unknown]; Region: COG2850
439851005686	Cupin domain; Region: Cupin_2; cl17218
439851005687	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
439851005688	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
439851005689	metal binding site [ion binding]; metal-binding site
439851005690	dimer interface [polypeptide binding]; other site
439851005691	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
439851005692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851005693	Walker A/P-loop; other site
439851005694	ATP binding site [chemical binding]; other site
439851005695	Q-loop/lid; other site
439851005696	ABC transporter signature motif; other site
439851005697	Walker B; other site
439851005698	D-loop; other site
439851005699	H-loop/switch region; other site
439851005700	TOBE domain; Region: TOBE_2; pfam08402
439851005701	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
439851005702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851005703	dimer interface [polypeptide binding]; other site
439851005704	conserved gate region; other site
439851005705	putative PBP binding loops; other site
439851005706	ABC-ATPase subunit interface; other site
439851005707	Sif protein; Region: Sif; pfam06767
439851005708	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
439851005709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851005710	dimer interface [polypeptide binding]; other site
439851005711	conserved gate region; other site
439851005712	putative PBP binding loops; other site
439851005713	ABC-ATPase subunit interface; other site
439851005714	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
439851005715	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
439851005716	NAD-dependent deacetylase; Provisional; Region: PRK00481
439851005717	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
439851005718	NAD+ binding site [chemical binding]; other site
439851005719	substrate binding site [chemical binding]; other site
439851005720	Zn binding site [ion binding]; other site
439851005721	fructokinase; Reviewed; Region: PRK09557
439851005722	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851005723	nucleotide binding site [chemical binding]; other site
439851005724	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
439851005725	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
439851005726	FtsX-like permease family; Region: FtsX; pfam02687
439851005727	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
439851005728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
439851005729	Walker A/P-loop; other site
439851005730	ATP binding site [chemical binding]; other site
439851005731	Q-loop/lid; other site
439851005732	ABC transporter signature motif; other site
439851005733	Walker B; other site
439851005734	D-loop; other site
439851005735	H-loop/switch region; other site
439851005736	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
439851005737	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
439851005738	FtsX-like permease family; Region: FtsX; pfam02687
439851005739	transcription-repair coupling factor; Provisional; Region: PRK10689
439851005740	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
439851005741	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851005742	ATP binding site [chemical binding]; other site
439851005743	putative Mg++ binding site [ion binding]; other site
439851005744	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851005745	nucleotide binding region [chemical binding]; other site
439851005746	ATP-binding site [chemical binding]; other site
439851005747	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
439851005748	L,D-transpeptidase; Provisional; Region: PRK10190
439851005749	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851005750	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439851005751	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851005752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439851005753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851005754	hypothetical protein; Provisional; Region: PRK11280
439851005755	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
439851005756	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851005757	hypothetical protein; Provisional; Region: PRK04940
439851005758	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
439851005759	beta-hexosaminidase; Provisional; Region: PRK05337
439851005760	thiamine kinase; Region: ycfN_thiK; TIGR02721
439851005761	thiamine kinase; Provisional; Region: thiK; PRK10271
439851005762	substrate binding site [chemical binding]; other site
439851005763	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
439851005764	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
439851005765	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
439851005766	putative dimer interface [polypeptide binding]; other site
439851005767	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
439851005768	nucleotide binding site/active site [active]
439851005769	HIT family signature motif; other site
439851005770	catalytic residue [active]
439851005771	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
439851005772	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851005773	N-terminal plug; other site
439851005774	ligand-binding site [chemical binding]; other site
439851005775	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
439851005776	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439851005777	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439851005778	active site turn [active]
439851005779	phosphorylation site [posttranslational modification]
439851005780	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
439851005781	active site
439851005782	DNA polymerase III subunit delta'; Validated; Region: PRK07993
439851005783	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
439851005784	thymidylate kinase; Validated; Region: tmk; PRK00698
439851005785	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
439851005786	TMP-binding site; other site
439851005787	ATP-binding site [chemical binding]; other site
439851005788	conserved hypothetical protein, YceG family; Region: TIGR00247
439851005789	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
439851005790	dimerization interface [polypeptide binding]; other site
439851005791	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
439851005792	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
439851005793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851005794	catalytic residue [active]
439851005795	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
439851005796	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
439851005797	dimer interface [polypeptide binding]; other site
439851005798	active site
439851005799	acyl carrier protein; Provisional; Region: acpP; PRK00982
439851005800	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
439851005801	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
439851005802	NAD(P) binding site [chemical binding]; other site
439851005803	homotetramer interface [polypeptide binding]; other site
439851005804	homodimer interface [polypeptide binding]; other site
439851005805	active site
439851005806	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
439851005807	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
439851005808	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
439851005809	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
439851005810	dimer interface [polypeptide binding]; other site
439851005811	active site
439851005812	CoA binding pocket [chemical binding]; other site
439851005813	putative phosphate acyltransferase; Provisional; Region: PRK05331
439851005814	hypothetical protein; Provisional; Region: PRK11193
439851005815	Maf-like protein; Region: Maf; pfam02545
439851005816	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
439851005817	active site
439851005818	dimer interface [polypeptide binding]; other site
439851005819	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
439851005820	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851005821	RNA binding surface [nucleotide binding]; other site
439851005822	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
439851005823	active site
439851005824	RNase E 5' UTR element
439851005825	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
439851005826	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
439851005827	homodimer interface [polypeptide binding]; other site
439851005828	oligonucleotide binding site [chemical binding]; other site
439851005829	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
439851005830	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
439851005831	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
439851005832	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
439851005833	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
439851005834	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
439851005835	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
439851005836	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
439851005837	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
439851005838	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
439851005839	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
439851005840	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
439851005841	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
439851005842	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439851005843	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
439851005844	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
439851005845	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439851005846	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
439851005847	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
439851005848	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439851005849	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
439851005850	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
439851005851	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
439851005852	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
439851005853	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
439851005854	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
439851005855	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439851005856	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
439851005857	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
439851005858	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
439851005859	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
439851005860	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
439851005861	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
439851005862	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
439851005863	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
439851005864	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
439851005865	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
439851005866	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
439851005867	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439851005868	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439851005869	hypothetical protein; Provisional; Region: PRK11239
439851005870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
439851005871	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
439851005872	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
439851005873	multidrug resistance protein MdtH; Provisional; Region: PRK11646
439851005874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005875	putative substrate translocation pore; other site
439851005876	glutaredoxin 2; Provisional; Region: PRK10387
439851005877	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
439851005878	C-terminal domain interface [polypeptide binding]; other site
439851005879	GSH binding site (G-site) [chemical binding]; other site
439851005880	catalytic residues [active]
439851005881	putative dimer interface [polypeptide binding]; other site
439851005882	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
439851005883	N-terminal domain interface [polypeptide binding]; other site
439851005884	lipoprotein; Provisional; Region: PRK10598
439851005885	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
439851005886	active site
439851005887	substrate binding pocket [chemical binding]; other site
439851005888	dimer interface [polypeptide binding]; other site
439851005889	DNA damage-inducible protein I; Provisional; Region: PRK10597
439851005890	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
439851005891	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
439851005892	hydroxyglutarate oxidase; Provisional; Region: PRK11728
439851005893	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
439851005894	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
439851005895	hypothetical protein; Provisional; Region: PRK03757
439851005896	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
439851005897	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
439851005898	active site residue [active]
439851005899	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
439851005900	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
439851005901	putative acyl-acceptor binding pocket; other site
439851005902	drug efflux system protein MdtG; Provisional; Region: PRK09874
439851005903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851005904	putative substrate translocation pore; other site
439851005905	secY/secA suppressor protein; Provisional; Region: PRK11467
439851005906	lipoprotein; Provisional; Region: PRK10175
439851005907	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
439851005908	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
439851005909	Ligand binding site; other site
439851005910	DXD motif; other site
439851005911	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
439851005912	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
439851005913	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
439851005914	Acyltransferase family; Region: Acyl_transf_3; pfam01757
439851005915	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
439851005916	PLD-like domain; Region: PLDc_2; pfam13091
439851005917	putative active site [active]
439851005918	catalytic site [active]
439851005919	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
439851005920	PLD-like domain; Region: PLDc_2; pfam13091
439851005921	putative active site [active]
439851005922	catalytic site [active]
439851005923	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
439851005924	putative ADP-ribose binding site [chemical binding]; other site
439851005925	putative active site [active]
439851005926	Fimbrial protein; Region: Fimbrial; cl01416
439851005927	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
439851005928	major curlin subunit; Provisional; Region: csgA; PRK10051
439851005929	Curlin associated repeat; Region: Curlin_rpt; pfam07012
439851005930	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
439851005931	Curlin associated repeat; Region: Curlin_rpt; pfam07012
439851005932	Curlin associated repeat; Region: Curlin_rpt; pfam07012
439851005933	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
439851005934	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851005935	DNA binding residues [nucleotide binding]
439851005936	dimerization interface [polypeptide binding]; other site
439851005937	curli assembly protein CsgE; Provisional; Region: PRK10386
439851005938	curli assembly protein CsgF; Provisional; Region: PRK10050
439851005939	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
439851005940	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
439851005941	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
439851005942	putative hydrolase; Validated; Region: PRK09248
439851005943	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
439851005944	active site
439851005945	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
439851005946	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
439851005947	putative ligand binding site [chemical binding]; other site
439851005948	NAD binding site [chemical binding]; other site
439851005949	dimerization interface [polypeptide binding]; other site
439851005950	catalytic site [active]
439851005951	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439851005952	DNA-binding interface [nucleotide binding]; DNA binding site
439851005953	Transposase; Region: DEDD_Tnp_IS110; pfam01548
439851005954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
439851005955	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
439851005956	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439851005957	DNA-binding interface [nucleotide binding]; DNA binding site
439851005958	type III secretion system protein; Provisional; Region: PRK15383
439851005959	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
439851005960	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
439851005961	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439851005962	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
439851005963	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
439851005964	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
439851005965	Phage protein GP46; Region: GP46; pfam07409
439851005966	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
439851005967	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
439851005968	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
439851005969	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
439851005970	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
439851005971	Phage tail tube protein; Region: Tail_tube; pfam10618
439851005972	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
439851005973	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
439851005974	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
439851005975	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
439851005976	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
439851005977	oligomerization interface [polypeptide binding]; other site
439851005978	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
439851005979	Phage capsid family; Region: Phage_capsid; pfam05065
439851005980	Phage-related protein [Function unknown]; Region: COG4695
439851005981	Phage portal protein; Region: Phage_portal; pfam04860
439851005982	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
439851005983	Phage terminase, small subunit; Region: Terminase_4; pfam05119
439851005984	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
439851005985	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
439851005986	active site
439851005987	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
439851005988	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851005989	catalytic residue [active]
439851005990	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
439851005991	Antitermination protein; Region: Antiterm; pfam03589
439851005992	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
439851005993	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
439851005994	Zn binding sites [ion binding]; other site
439851005995	Antitermination protein; Region: Antiterm; pfam03589
439851005996	Protein of unknown function (DUF968); Region: DUF968; pfam06147
439851005997	KilA-N domain; Region: KilA-N; pfam04383
439851005998	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
439851005999	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
439851006000	PerC transcriptional activator; Region: PerC; pfam06069
439851006001	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524
439851006002	Ash protein family; Region: Phage_ASH; pfam10554
439851006003	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
439851006004	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851006005	non-specific DNA binding site [nucleotide binding]; other site
439851006006	salt bridge; other site
439851006007	sequence-specific DNA binding site [nucleotide binding]; other site
439851006008	Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065
439851006009	HD domain; Region: HD_3; cl17350
439851006010	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
439851006011	Methyltransferase domain; Region: Methyltransf_25; pfam13649
439851006012	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
439851006013	active site
439851006014	catalytic site [active]
439851006015	substrate binding site [chemical binding]; other site
439851006016	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
439851006017	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439851006018	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
439851006019	dimer interface [polypeptide binding]; other site
439851006020	active site
439851006021	Int/Topo IB signature motif; other site
439851006022	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
439851006023	integrase; Provisional; Region: PRK09692
439851006024	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
439851006025	active site
439851006026	Int/Topo IB signature motif; other site
439851006027	TIR domain; Region: TIR_2; pfam13676
439851006028	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
439851006029	Phage Tail Collar Domain; Region: Collar; pfam07484
439851006030	PilS N terminal; Region: PilS; pfam08805
439851006031	Conjugal transfer protein TraD; Region: TraD; pfam06412
439851006032	MobA/MobL family; Region: MobA_MobL; pfam03389
439851006033	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
439851006034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851006035	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
439851006036	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
439851006037	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
439851006038	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
439851006039	active site
439851006040	NTP binding site [chemical binding]; other site
439851006041	metal binding triad [ion binding]; metal-binding site
439851006042	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
439851006043	putative protease; Region: PHA00666
439851006044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
439851006045	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851006046	Sel1 repeat; Region: Sel1; pfam08238
439851006047	Sel1-like repeats; Region: SEL1; smart00671
439851006048	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
439851006049	AMP nucleosidase; Provisional; Region: PRK08292
439851006050	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
439851006051	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
439851006052	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
439851006053	L,D-transpeptidase; Provisional; Region: PRK10190
439851006054	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439851006055	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
439851006056	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
439851006057	putative dimer interface [polypeptide binding]; other site
439851006058	active site pocket [active]
439851006059	putative cataytic base [active]
439851006060	cobalamin synthase; Reviewed; Region: cobS; PRK00235
439851006061	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
439851006062	homotrimer interface [polypeptide binding]; other site
439851006063	Walker A motif; other site
439851006064	GTP binding site [chemical binding]; other site
439851006065	Walker B motif; other site
439851006066	cobyric acid synthase; Provisional; Region: PRK00784
439851006067	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
439851006068	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
439851006069	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
439851006070	catalytic triad [active]
439851006071	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
439851006072	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
439851006073	Walker A/P-loop; other site
439851006074	ATP binding site [chemical binding]; other site
439851006075	Q-loop/lid; other site
439851006076	ABC transporter signature motif; other site
439851006077	Walker B; other site
439851006078	D-loop; other site
439851006079	H-loop/switch region; other site
439851006080	cobalt transport protein CbiQ; Provisional; Region: PRK15485
439851006081	cobalt transport protein CbiN; Provisional; Region: PRK02898
439851006082	cobalt transport protein CbiM; Validated; Region: PRK08319
439851006083	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
439851006084	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
439851006085	active site
439851006086	SAM binding site [chemical binding]; other site
439851006087	homodimer interface [polypeptide binding]; other site
439851006088	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
439851006089	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
439851006090	active site
439851006091	C-terminal domain interface [polypeptide binding]; other site
439851006092	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
439851006093	active site
439851006094	N-terminal domain interface [polypeptide binding]; other site
439851006095	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
439851006096	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
439851006097	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
439851006098	active site
439851006099	SAM binding site [chemical binding]; other site
439851006100	homodimer interface [polypeptide binding]; other site
439851006101	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
439851006102	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
439851006103	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
439851006104	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
439851006105	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
439851006106	active site
439851006107	SAM binding site [chemical binding]; other site
439851006108	homodimer interface [polypeptide binding]; other site
439851006109	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
439851006110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851006111	S-adenosylmethionine binding site [chemical binding]; other site
439851006112	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
439851006113	active site
439851006114	putative homodimer interface [polypeptide binding]; other site
439851006115	SAM binding site [chemical binding]; other site
439851006116	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
439851006117	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
439851006118	Precorrin-8X methylmutase; Region: CbiC; pfam02570
439851006119	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
439851006120	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
439851006121	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
439851006122	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
439851006123	catalytic triad [active]
439851006124	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
439851006125	Sensory domain found in PocR; Region: PocR; pfam10114
439851006126	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851006127	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851006128	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851006129	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
439851006130	amphipathic channel; other site
439851006131	Asn-Pro-Ala signature motifs; other site
439851006132	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
439851006133	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
439851006134	Hexamer interface [polypeptide binding]; other site
439851006135	Putative hexagonal pore residue; other site
439851006136	propanediol utilization protein PduB; Provisional; Region: PRK15415
439851006137	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
439851006138	putative hexamer interface [polypeptide binding]; other site
439851006139	putative hexagonal pore; other site
439851006140	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
439851006141	putative hexamer interface [polypeptide binding]; other site
439851006142	putative hexagonal pore; other site
439851006143	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
439851006144	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
439851006145	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
439851006146	alpha-beta subunit interface [polypeptide binding]; other site
439851006147	alpha-gamma subunit interface [polypeptide binding]; other site
439851006148	active site
439851006149	substrate and K+ binding site; other site
439851006150	K+ binding site [ion binding]; other site
439851006151	cobalamin binding site [chemical binding]; other site
439851006152	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
439851006153	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
439851006154	Cell division protein FtsA; Region: FtsA; cl17206
439851006155	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
439851006156	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
439851006157	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
439851006158	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
439851006159	Hexamer interface [polypeptide binding]; other site
439851006160	Putative hexagonal pore residue; other site
439851006161	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
439851006162	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
439851006163	putative hexamer interface [polypeptide binding]; other site
439851006164	putative hexagonal pore; other site
439851006165	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
439851006166	Propanediol utilisation protein PduL; Region: PduL; pfam06130
439851006167	Propanediol utilisation protein PduL; Region: PduL; pfam06130
439851006168	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
439851006169	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
439851006170	Hexamer/Pentamer interface [polypeptide binding]; other site
439851006171	central pore; other site
439851006172	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
439851006173	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
439851006174	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
439851006175	putative catalytic cysteine [active]
439851006176	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
439851006177	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
439851006178	putative active site [active]
439851006179	metal binding site [ion binding]; metal-binding site
439851006180	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
439851006181	SLBB domain; Region: SLBB; pfam10531
439851006182	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
439851006183	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
439851006184	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
439851006185	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
439851006186	putative hexamer interface [polypeptide binding]; other site
439851006187	putative hexagonal pore; other site
439851006188	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
439851006189	putative hexamer interface [polypeptide binding]; other site
439851006190	putative hexagonal pore; other site
439851006191	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
439851006192	putative hexamer interface [polypeptide binding]; other site
439851006193	putative hexagonal pore; other site
439851006194	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
439851006195	G3 box; other site
439851006196	Switch II region; other site
439851006197	GTP/Mg2+ binding site [chemical binding]; other site
439851006198	G4 box; other site
439851006199	G5 box; other site
439851006200	propionate kinase; Reviewed; Region: PRK12397
439851006201	propionate/acetate kinase; Provisional; Region: PRK12379
439851006202	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
439851006203	hypothetical protein; Provisional; Region: PRK05423
439851006204	Predicted membrane protein [Function unknown]; Region: COG1289
439851006205	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439851006206	DNA gyrase inhibitor; Provisional; Region: PRK10016
439851006207	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
439851006208	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
439851006209	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
439851006210	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
439851006211	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
439851006212	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
439851006213	4Fe-4S binding domain; Region: Fer4; cl02805
439851006214	thiosulfate reductase PhsA; Provisional; Region: PRK15488
439851006215	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
439851006216	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
439851006217	putative [Fe4-S4] binding site [ion binding]; other site
439851006218	putative molybdopterin cofactor binding site [chemical binding]; other site
439851006219	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439851006220	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
439851006221	putative molybdopterin cofactor binding site; other site
439851006222	E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377
439851006223	SopA-like central domain; Region: SopA; pfam13981
439851006224	SopA-like catalytic domain; Region: SopA_C; pfam13979
439851006225	exonuclease I; Provisional; Region: sbcB; PRK11779
439851006226	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
439851006227	active site
439851006228	catalytic site [active]
439851006229	substrate binding site [chemical binding]; other site
439851006230	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
439851006231	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
439851006232	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851006233	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
439851006234	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851006235	dimerization interface [polypeptide binding]; other site
439851006236	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
439851006237	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
439851006238	putative NAD(P) binding site [chemical binding]; other site
439851006239	Histidine operon leader
439851006240	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
439851006241	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
439851006242	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
439851006243	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
439851006244	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
439851006245	NAD binding site [chemical binding]; other site
439851006246	dimerization interface [polypeptide binding]; other site
439851006247	product binding site; other site
439851006248	substrate binding site [chemical binding]; other site
439851006249	zinc binding site [ion binding]; other site
439851006250	catalytic residues [active]
439851006251	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
439851006252	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851006253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851006254	homodimer interface [polypeptide binding]; other site
439851006255	catalytic residue [active]
439851006256	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
439851006257	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851006258	active site
439851006259	motif I; other site
439851006260	motif II; other site
439851006261	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
439851006262	putative active site pocket [active]
439851006263	4-fold oligomerization interface [polypeptide binding]; other site
439851006264	metal binding residues [ion binding]; metal-binding site
439851006265	3-fold/trimer interface [polypeptide binding]; other site
439851006266	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
439851006267	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
439851006268	putative active site [active]
439851006269	oxyanion strand; other site
439851006270	catalytic triad [active]
439851006271	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
439851006272	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
439851006273	catalytic residues [active]
439851006274	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
439851006275	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
439851006276	substrate binding site [chemical binding]; other site
439851006277	glutamase interaction surface [polypeptide binding]; other site
439851006278	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
439851006279	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
439851006280	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
439851006281	metal binding site [ion binding]; metal-binding site
439851006282	chain length determinant protein WzzB; Provisional; Region: PRK15471
439851006283	Chain length determinant protein; Region: Wzz; pfam02706
439851006284	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
439851006285	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
439851006286	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
439851006287	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
439851006288	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
439851006289	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439851006290	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
439851006291	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
439851006292	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
439851006293	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
439851006294	Bacterial sugar transferase; Region: Bac_transf; pfam02397
439851006295	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
439851006296	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
439851006297	active site
439851006298	substrate binding site [chemical binding]; other site
439851006299	metal binding site [ion binding]; metal-binding site
439851006300	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
439851006301	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
439851006302	Substrate binding site; other site
439851006303	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
439851006304	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
439851006305	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
439851006306	active site
439851006307	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439851006308	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
439851006309	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
439851006310	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
439851006311	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
439851006312	active site
439851006313	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
439851006314	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
439851006315	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
439851006316	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
439851006317	NAD binding site [chemical binding]; other site
439851006318	homotetramer interface [polypeptide binding]; other site
439851006319	homodimer interface [polypeptide binding]; other site
439851006320	active site
439851006321	substrate binding site [chemical binding]; other site
439851006322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
439851006323	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
439851006324	NAD(P) binding site [chemical binding]; other site
439851006325	active site
439851006326	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
439851006327	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
439851006328	inhibitor-cofactor binding pocket; inhibition site
439851006329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851006330	catalytic residue [active]
439851006331	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
439851006332	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
439851006333	NAD binding site [chemical binding]; other site
439851006334	homotetramer interface [polypeptide binding]; other site
439851006335	homodimer interface [polypeptide binding]; other site
439851006336	substrate binding site [chemical binding]; other site
439851006337	active site
439851006338	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
439851006339	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
439851006340	substrate binding site; other site
439851006341	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
439851006342	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
439851006343	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
439851006344	substrate binding site; other site
439851006345	tetramer interface; other site
439851006346	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
439851006347	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
439851006348	NADP binding site [chemical binding]; other site
439851006349	active site
439851006350	putative substrate binding site [chemical binding]; other site
439851006351	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
439851006352	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
439851006353	NAD binding site [chemical binding]; other site
439851006354	substrate binding site [chemical binding]; other site
439851006355	homodimer interface [polypeptide binding]; other site
439851006356	active site
439851006357	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
439851006358	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
439851006359	active site
439851006360	tetramer interface; other site
439851006361	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
439851006362	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
439851006363	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
439851006364	putative ADP-binding pocket [chemical binding]; other site
439851006365	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
439851006366	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
439851006367	colanic acid exporter; Provisional; Region: PRK10459
439851006368	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
439851006369	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
439851006370	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
439851006371	phosphomannomutase CpsG; Provisional; Region: PRK15414
439851006372	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
439851006373	active site
439851006374	substrate binding site [chemical binding]; other site
439851006375	metal binding site [ion binding]; metal-binding site
439851006376	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
439851006377	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
439851006378	Substrate binding site; other site
439851006379	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
439851006380	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
439851006381	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
439851006382	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
439851006383	active site
439851006384	GDP-Mannose binding site [chemical binding]; other site
439851006385	dimer interface [polypeptide binding]; other site
439851006386	modified nudix motif
439851006387	metal binding site [ion binding]; metal-binding site
439851006388	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
439851006389	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
439851006390	NADP binding site [chemical binding]; other site
439851006391	active site
439851006392	putative substrate binding site [chemical binding]; other site
439851006393	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
439851006394	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
439851006395	NADP-binding site; other site
439851006396	homotetramer interface [polypeptide binding]; other site
439851006397	substrate binding site [chemical binding]; other site
439851006398	homodimer interface [polypeptide binding]; other site
439851006399	active site
439851006400	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
439851006401	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
439851006402	putative trimer interface [polypeptide binding]; other site
439851006403	putative active site [active]
439851006404	putative substrate binding site [chemical binding]; other site
439851006405	putative CoA binding site [chemical binding]; other site
439851006406	putative glycosyl transferase; Provisional; Region: PRK10063
439851006407	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
439851006408	metal-binding site
439851006409	putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010
439851006410	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
439851006411	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
439851006412	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
439851006413	putative acyl transferase; Provisional; Region: PRK10191
439851006414	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
439851006415	trimer interface [polypeptide binding]; other site
439851006416	active site
439851006417	substrate binding site [chemical binding]; other site
439851006418	CoA binding site [chemical binding]; other site
439851006419	putative glycosyl transferase; Provisional; Region: PRK10018
439851006420	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
439851006421	active site
439851006422	tyrosine kinase; Provisional; Region: PRK11519
439851006423	Chain length determinant protein; Region: Wzz; pfam02706
439851006424	Chain length determinant protein; Region: Wzz; cl15801
439851006425	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
439851006426	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
439851006427	Low molecular weight phosphatase family; Region: LMWPc; cd00115
439851006428	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
439851006429	active site
439851006430	polysaccharide export protein Wza; Provisional; Region: PRK15078
439851006431	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
439851006432	putative assembly protein; Provisional; Region: PRK10833
439851006433	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
439851006434	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
439851006435	trimer interface [polypeptide binding]; other site
439851006436	active site
439851006437	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
439851006438	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
439851006439	ATP-binding site [chemical binding]; other site
439851006440	Sugar specificity; other site
439851006441	Pyrimidine base specificity; other site
439851006442	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
439851006443	AlkA N-terminal domain; Region: AlkA_N; pfam06029
439851006444	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
439851006445	minor groove reading motif; other site
439851006446	helix-hairpin-helix signature motif; other site
439851006447	substrate binding pocket [chemical binding]; other site
439851006448	active site
439851006449	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
439851006450	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851006451	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851006452	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
439851006453	Protein export membrane protein; Region: SecD_SecF; cl14618
439851006454	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
439851006455	putative transporter; Provisional; Region: PRK10504
439851006456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006457	putative substrate translocation pore; other site
439851006458	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
439851006459	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851006460	dimerization interface [polypeptide binding]; other site
439851006461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851006462	dimer interface [polypeptide binding]; other site
439851006463	phosphorylation site [posttranslational modification]
439851006464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851006465	ATP binding site [chemical binding]; other site
439851006466	Mg2+ binding site [ion binding]; other site
439851006467	G-X-G motif; other site
439851006468	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
439851006469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851006470	active site
439851006471	phosphorylation site [posttranslational modification]
439851006472	intermolecular recognition site; other site
439851006473	dimerization interface [polypeptide binding]; other site
439851006474	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851006475	DNA binding site [nucleotide binding]
439851006476	PcfJ-like protein; Region: PcfJ; pfam14284
439851006477	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
439851006478	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
439851006479	putative protease; Provisional; Region: PRK15452
439851006480	Peptidase family U32; Region: Peptidase_U32; pfam01136
439851006481	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
439851006482	lipid kinase; Reviewed; Region: PRK13054
439851006483	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
439851006484	nucleoside transporter; Region: 2A0110; TIGR00889
439851006485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006486	putative substrate translocation pore; other site
439851006487	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
439851006488	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851006489	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
439851006490	substrate binding site [chemical binding]; other site
439851006491	ATP binding site [chemical binding]; other site
439851006492	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
439851006493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851006494	DNA-binding site [nucleotide binding]; DNA binding site
439851006495	UTRA domain; Region: UTRA; pfam07702
439851006496	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
439851006497	dimer interface [polypeptide binding]; other site
439851006498	substrate binding site [chemical binding]; other site
439851006499	ATP binding site [chemical binding]; other site
439851006500	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
439851006501	substrate binding site [chemical binding]; other site
439851006502	multimerization interface [polypeptide binding]; other site
439851006503	ATP binding site [chemical binding]; other site
439851006504	Predicted integral membrane protein [Function unknown]; Region: COG5455
439851006505	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
439851006506	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
439851006507	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
439851006508	PapC N-terminal domain; Region: PapC_N; pfam13954
439851006509	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851006510	PapC C-terminal domain; Region: PapC_C; pfam13953
439851006511	fimbrial chaperone protein PegB; Provisional; Region: PRK15218
439851006512	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851006513	fimbrial chaperone protein; Provisional; Region: PRK15220
439851006514	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
439851006515	antiporter inner membrane protein; Provisional; Region: PRK11670
439851006516	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
439851006517	Walker A motif; other site
439851006518	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
439851006519	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
439851006520	active site
439851006521	HIGH motif; other site
439851006522	KMSKS motif; other site
439851006523	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
439851006524	tRNA binding surface [nucleotide binding]; other site
439851006525	anticodon binding site; other site
439851006526	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
439851006527	dimer interface [polypeptide binding]; other site
439851006528	putative tRNA-binding site [nucleotide binding]; other site
439851006529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
439851006530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
439851006531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
439851006532	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
439851006533	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
439851006534	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
439851006535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851006536	active site
439851006537	phosphorylation site [posttranslational modification]
439851006538	intermolecular recognition site; other site
439851006539	dimerization interface [polypeptide binding]; other site
439851006540	LytTr DNA-binding domain; Region: LytTR; pfam04397
439851006541	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
439851006542	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
439851006543	GAF domain; Region: GAF; pfam01590
439851006544	Histidine kinase; Region: His_kinase; pfam06580
439851006545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851006546	ATP binding site [chemical binding]; other site
439851006547	Mg2+ binding site [ion binding]; other site
439851006548	G-X-G motif; other site
439851006549	transcriptional regulator MirA; Provisional; Region: PRK15043
439851006550	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
439851006551	DNA binding residues [nucleotide binding]
439851006552	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
439851006553	putative PBP binding loops; other site
439851006554	ABC-ATPase subunit interface; other site
439851006555	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
439851006556	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
439851006557	Walker A/P-loop; other site
439851006558	ATP binding site [chemical binding]; other site
439851006559	Q-loop/lid; other site
439851006560	ABC transporter signature motif; other site
439851006561	Walker B; other site
439851006562	D-loop; other site
439851006563	H-loop/switch region; other site
439851006564	CBS domain; Region: CBS; pfam00571
439851006565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851006566	dimer interface [polypeptide binding]; other site
439851006567	conserved gate region; other site
439851006568	ABC-ATPase subunit interface; other site
439851006569	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
439851006570	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
439851006571	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
439851006572	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
439851006573	D-lactate dehydrogenase; Provisional; Region: PRK11183
439851006574	FAD binding domain; Region: FAD_binding_4; pfam01565
439851006575	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
439851006576	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
439851006577	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
439851006578	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
439851006579	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439851006580	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
439851006581	oxidoreductase; Provisional; Region: PRK12743
439851006582	classical (c) SDRs; Region: SDR_c; cd05233
439851006583	NAD(P) binding site [chemical binding]; other site
439851006584	active site
439851006585	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
439851006586	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
439851006587	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
439851006588	FMN binding site [chemical binding]; other site
439851006589	active site
439851006590	catalytic residues [active]
439851006591	substrate binding site [chemical binding]; other site
439851006592	salicylate hydroxylase; Provisional; Region: PRK08163
439851006593	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
439851006594	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
439851006595	maleylacetoacetate isomerase; Region: maiA; TIGR01262
439851006596	C-terminal domain interface [polypeptide binding]; other site
439851006597	GSH binding site (G-site) [chemical binding]; other site
439851006598	putative dimer interface [polypeptide binding]; other site
439851006599	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
439851006600	dimer interface [polypeptide binding]; other site
439851006601	N-terminal domain interface [polypeptide binding]; other site
439851006602	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
439851006603	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
439851006604	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
439851006605	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
439851006606	Cupin domain; Region: Cupin_2; pfam07883
439851006607	Cupin domain; Region: Cupin_2; pfam07883
439851006608	benzoate transport; Region: 2A0115; TIGR00895
439851006609	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006610	putative substrate translocation pore; other site
439851006611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006612	putative substrate translocation pore; other site
439851006613	hypothetical protein; Provisional; Region: PRK01821
439851006614	hypothetical protein; Provisional; Region: PRK10711
439851006615	cytidine deaminase; Provisional; Region: PRK09027
439851006616	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
439851006617	active site
439851006618	catalytic motif [active]
439851006619	Zn binding site [ion binding]; other site
439851006620	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
439851006621	active site
439851006622	catalytic motif [active]
439851006623	Zn binding site [ion binding]; other site
439851006624	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439851006625	putative active site [active]
439851006626	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
439851006627	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
439851006628	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
439851006629	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851006630	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
439851006631	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
439851006632	homodimer interface [polypeptide binding]; other site
439851006633	active site
439851006634	FMN binding site [chemical binding]; other site
439851006635	substrate binding site [chemical binding]; other site
439851006636	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439851006637	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439851006638	TM-ABC transporter signature motif; other site
439851006639	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
439851006640	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851006641	DNA binding site [nucleotide binding]
439851006642	domain linker motif; other site
439851006643	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439851006644	dimerization interface (closed form) [polypeptide binding]; other site
439851006645	ligand binding site [chemical binding]; other site
439851006646	Predicted membrane protein [Function unknown]; Region: COG2311
439851006647	hypothetical protein; Provisional; Region: PRK10835
439851006648	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
439851006649	GTP cyclohydrolase I; Provisional; Region: PLN03044
439851006650	active site
439851006651	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
439851006652	S-formylglutathione hydrolase; Region: PLN02442
439851006653	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
439851006654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851006655	non-specific DNA binding site [nucleotide binding]; other site
439851006656	salt bridge; other site
439851006657	sequence-specific DNA binding site [nucleotide binding]; other site
439851006658	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
439851006659	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439851006660	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439851006661	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
439851006662	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
439851006663	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851006664	motif II; other site
439851006665	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
439851006666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006667	putative substrate translocation pore; other site
439851006668	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
439851006669	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851006670	N-terminal plug; other site
439851006671	ligand-binding site [chemical binding]; other site
439851006672	lysine transporter; Provisional; Region: PRK10836
439851006673	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
439851006674	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851006675	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
439851006676	putative dimerization interface [polypeptide binding]; other site
439851006677	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
439851006678	endonuclease IV; Provisional; Region: PRK01060
439851006679	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
439851006680	AP (apurinic/apyrimidinic) site pocket; other site
439851006681	DNA interaction; other site
439851006682	Metal-binding active site; metal-binding site
439851006683	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
439851006684	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
439851006685	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
439851006686	active site
439851006687	P-loop; other site
439851006688	phosphorylation site [posttranslational modification]
439851006689	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
439851006690	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
439851006691	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
439851006692	putative substrate binding site [chemical binding]; other site
439851006693	putative ATP binding site [chemical binding]; other site
439851006694	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
439851006695	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851006696	active site
439851006697	phosphorylation site [posttranslational modification]
439851006698	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439851006699	dimerization domain swap beta strand [polypeptide binding]; other site
439851006700	regulatory protein interface [polypeptide binding]; other site
439851006701	active site
439851006702	regulatory phosphorylation site [posttranslational modification]; other site
439851006703	sugar efflux transporter B; Provisional; Region: PRK15011
439851006704	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006705	putative substrate translocation pore; other site
439851006706	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
439851006707	elongation factor P; Provisional; Region: PRK04542
439851006708	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
439851006709	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
439851006710	RNA binding site [nucleotide binding]; other site
439851006711	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
439851006712	RNA binding site [nucleotide binding]; other site
439851006713	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
439851006714	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
439851006715	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
439851006716	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439851006717	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
439851006718	active site
439851006719	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
439851006720	NlpC/P60 family; Region: NLPC_P60; pfam00877
439851006721	phage resistance protein; Provisional; Region: PRK10551
439851006722	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439851006723	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851006724	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
439851006725	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
439851006726	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
439851006727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851006728	dimer interface [polypeptide binding]; other site
439851006729	conserved gate region; other site
439851006730	putative PBP binding loops; other site
439851006731	ABC-ATPase subunit interface; other site
439851006732	microcin C ABC transporter permease; Provisional; Region: PRK15021
439851006733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851006734	dimer interface [polypeptide binding]; other site
439851006735	conserved gate region; other site
439851006736	ABC-ATPase subunit interface; other site
439851006737	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
439851006738	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851006739	Walker A/P-loop; other site
439851006740	ATP binding site [chemical binding]; other site
439851006741	Q-loop/lid; other site
439851006742	ABC transporter signature motif; other site
439851006743	Walker B; other site
439851006744	D-loop; other site
439851006745	H-loop/switch region; other site
439851006746	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
439851006747	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851006748	Walker A/P-loop; other site
439851006749	ATP binding site [chemical binding]; other site
439851006750	Q-loop/lid; other site
439851006751	ABC transporter signature motif; other site
439851006752	Walker B; other site
439851006753	D-loop; other site
439851006754	H-loop/switch region; other site
439851006755	hypothetical protein; Provisional; Region: PRK11835
439851006756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006757	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
439851006758	putative substrate translocation pore; other site
439851006759	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
439851006760	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851006761	RNA binding surface [nucleotide binding]; other site
439851006762	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
439851006763	active site
439851006764	uracil binding [chemical binding]; other site
439851006765	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
439851006766	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851006767	ATP binding site [chemical binding]; other site
439851006768	putative Mg++ binding site [ion binding]; other site
439851006769	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851006770	nucleotide binding region [chemical binding]; other site
439851006771	ATP-binding site [chemical binding]; other site
439851006772	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
439851006773	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
439851006774	5S rRNA interface [nucleotide binding]; other site
439851006775	CTC domain interface [polypeptide binding]; other site
439851006776	L16 interface [polypeptide binding]; other site
439851006777	Nucleoid-associated protein [General function prediction only]; Region: COG3081
439851006778	nucleoid-associated protein NdpA; Validated; Region: PRK00378
439851006779	hypothetical protein; Provisional; Region: PRK13689
439851006780	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
439851006781	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
439851006782	Sulfatase; Region: Sulfatase; cl17466
439851006783	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
439851006784	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
439851006785	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
439851006786	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
439851006787	Leucine-rich repeats; other site
439851006788	Substrate binding site [chemical binding]; other site
439851006789	DinI-like family; Region: DinI; cl11630
439851006790	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
439851006791	transcriptional regulator NarP; Provisional; Region: PRK10403
439851006792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851006793	active site
439851006794	phosphorylation site [posttranslational modification]
439851006795	intermolecular recognition site; other site
439851006796	dimerization interface [polypeptide binding]; other site
439851006797	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851006798	DNA binding residues [nucleotide binding]
439851006799	dimerization interface [polypeptide binding]; other site
439851006800	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
439851006801	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
439851006802	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
439851006803	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
439851006804	catalytic residues [active]
439851006805	central insert; other site
439851006806	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
439851006807	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
439851006808	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
439851006809	heme exporter protein CcmC; Region: ccmC; TIGR01191
439851006810	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
439851006811	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
439851006812	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851006813	Walker A/P-loop; other site
439851006814	ATP binding site [chemical binding]; other site
439851006815	Q-loop/lid; other site
439851006816	ABC transporter signature motif; other site
439851006817	Walker B; other site
439851006818	D-loop; other site
439851006819	H-loop/switch region; other site
439851006820	cytochrome c-type protein NapC; Provisional; Region: PRK10617
439851006821	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
439851006822	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
439851006823	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
439851006824	4Fe-4S binding domain; Region: Fer4_5; pfam12801
439851006825	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439851006826	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
439851006827	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
439851006828	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
439851006829	[4Fe-4S] binding site [ion binding]; other site
439851006830	molybdopterin cofactor binding site; other site
439851006831	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
439851006832	molybdopterin cofactor binding site; other site
439851006833	ferredoxin-type protein; Provisional; Region: PRK10194
439851006834	4Fe-4S binding domain; Region: Fer4; cl02805
439851006835	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
439851006836	secondary substrate binding site; other site
439851006837	primary substrate binding site; other site
439851006838	inhibition loop; other site
439851006839	dimerization interface [polypeptide binding]; other site
439851006840	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
439851006841	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
439851006842	Walker A/P-loop; other site
439851006843	ATP binding site [chemical binding]; other site
439851006844	Q-loop/lid; other site
439851006845	ABC transporter signature motif; other site
439851006846	Walker B; other site
439851006847	D-loop; other site
439851006848	H-loop/switch region; other site
439851006849	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
439851006850	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
439851006851	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
439851006852	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851006853	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851006854	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
439851006855	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
439851006856	DNA binding site [nucleotide binding]
439851006857	active site
439851006858	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
439851006859	ApbE family; Region: ApbE; pfam02424
439851006860	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439851006861	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439851006862	trimer interface [polypeptide binding]; other site
439851006863	eyelet of channel; other site
439851006864	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
439851006865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851006866	ATP binding site [chemical binding]; other site
439851006867	G-X-G motif; other site
439851006868	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439851006869	putative binding surface; other site
439851006870	active site
439851006871	transcriptional regulator RcsB; Provisional; Region: PRK10840
439851006872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851006873	active site
439851006874	phosphorylation site [posttranslational modification]
439851006875	intermolecular recognition site; other site
439851006876	dimerization interface [polypeptide binding]; other site
439851006877	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851006878	DNA binding residues [nucleotide binding]
439851006879	dimerization interface [polypeptide binding]; other site
439851006880	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
439851006881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851006882	dimer interface [polypeptide binding]; other site
439851006883	phosphorylation site [posttranslational modification]
439851006884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851006885	ATP binding site [chemical binding]; other site
439851006886	Mg2+ binding site [ion binding]; other site
439851006887	G-X-G motif; other site
439851006888	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
439851006889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851006890	active site
439851006891	phosphorylation site [posttranslational modification]
439851006892	intermolecular recognition site; other site
439851006893	dimerization interface [polypeptide binding]; other site
439851006894	DNA gyrase subunit A; Validated; Region: PRK05560
439851006895	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
439851006896	CAP-like domain; other site
439851006897	active site
439851006898	primary dimer interface [polypeptide binding]; other site
439851006899	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439851006900	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439851006901	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439851006902	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439851006903	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439851006904	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439851006905	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
439851006906	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
439851006907	active site pocket [active]
439851006908	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
439851006909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006910	putative substrate translocation pore; other site
439851006911	Transcriptional regulators [Transcription]; Region: GntR; COG1802
439851006912	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851006913	DNA-binding site [nucleotide binding]; DNA binding site
439851006914	FCD domain; Region: FCD; pfam07729
439851006915	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
439851006916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851006917	S-adenosylmethionine binding site [chemical binding]; other site
439851006918	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
439851006919	ATP cone domain; Region: ATP-cone; pfam03477
439851006920	Class I ribonucleotide reductase; Region: RNR_I; cd01679
439851006921	active site
439851006922	dimer interface [polypeptide binding]; other site
439851006923	catalytic residues [active]
439851006924	effector binding site; other site
439851006925	R2 peptide binding site; other site
439851006926	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
439851006927	dimer interface [polypeptide binding]; other site
439851006928	putative radical transfer pathway; other site
439851006929	diiron center [ion binding]; other site
439851006930	tyrosyl radical; other site
439851006931	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
439851006932	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439851006933	catalytic loop [active]
439851006934	iron binding site [ion binding]; other site
439851006935	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851006936	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006937	putative substrate translocation pore; other site
439851006938	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
439851006939	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851006940	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851006941	dimerization interface [polypeptide binding]; other site
439851006942	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
439851006943	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
439851006944	active site
439851006945	catalytic site [active]
439851006946	metal binding site [ion binding]; metal-binding site
439851006947	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
439851006948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006949	putative substrate translocation pore; other site
439851006950	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
439851006951	hydroxyglutarate oxidase; Provisional; Region: PRK11728
439851006952	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
439851006953	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
439851006954	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
439851006955	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
439851006956	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439851006957	Cysteine-rich domain; Region: CCG; pfam02754
439851006958	Cysteine-rich domain; Region: CCG; pfam02754
439851006959	hypothetical protein; Provisional; Region: PRK03673
439851006960	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
439851006961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851006962	D-galactonate transporter; Region: 2A0114; TIGR00893
439851006963	putative substrate translocation pore; other site
439851006964	L-rhamnonate dehydratase; Provisional; Region: PRK15440
439851006965	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
439851006966	putative active site pocket [active]
439851006967	putative metal binding site [ion binding]; other site
439851006968	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439851006969	Transcriptional regulator [Transcription]; Region: IclR; COG1414
439851006970	Bacterial transcriptional regulator; Region: IclR; pfam01614
439851006971	hypothetical protein; Provisional; Region: PRK03673
439851006972	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
439851006973	putative MPT binding site; other site
439851006974	Competence-damaged protein; Region: CinA; cl00666
439851006975	YfaZ precursor; Region: YfaZ; pfam07437
439851006976	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
439851006977	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
439851006978	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
439851006979	catalytic core [active]
439851006980	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
439851006981	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
439851006982	inhibitor-cofactor binding pocket; inhibition site
439851006983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851006984	catalytic residue [active]
439851006985	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
439851006986	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
439851006987	Ligand binding site; other site
439851006988	Putative Catalytic site; other site
439851006989	DXD motif; other site
439851006990	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
439851006991	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
439851006992	active site
439851006993	substrate binding site [chemical binding]; other site
439851006994	cosubstrate binding site; other site
439851006995	catalytic site [active]
439851006996	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
439851006997	active site
439851006998	hexamer interface [polypeptide binding]; other site
439851006999	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
439851007000	NAD binding site [chemical binding]; other site
439851007001	substrate binding site [chemical binding]; other site
439851007002	active site
439851007003	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
439851007004	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
439851007005	putative active site [active]
439851007006	putative catalytic site [active]
439851007007	putative Zn binding site [ion binding]; other site
439851007008	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
439851007009	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
439851007010	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
439851007011	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
439851007012	signal transduction protein PmrD; Provisional; Region: PRK15450
439851007013	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
439851007014	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
439851007015	acyl-activating enzyme (AAE) consensus motif; other site
439851007016	putative AMP binding site [chemical binding]; other site
439851007017	putative active site [active]
439851007018	putative CoA binding site [chemical binding]; other site
439851007019	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
439851007020	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
439851007021	active site
439851007022	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439851007023	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
439851007024	substrate binding site [chemical binding]; other site
439851007025	oxyanion hole (OAH) forming residues; other site
439851007026	trimer interface [polypeptide binding]; other site
439851007027	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
439851007028	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
439851007029	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
439851007030	dimer interface [polypeptide binding]; other site
439851007031	tetramer interface [polypeptide binding]; other site
439851007032	PYR/PP interface [polypeptide binding]; other site
439851007033	TPP binding site [chemical binding]; other site
439851007034	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
439851007035	TPP-binding site; other site
439851007036	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
439851007037	isochorismate synthases; Region: isochor_syn; TIGR00543
439851007038	hypothetical protein; Provisional; Region: PRK10404
439851007039	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851007040	Coenzyme A binding pocket [chemical binding]; other site
439851007041	ribonuclease BN; Region: true_RNase_BN; TIGR02649
439851007042	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
439851007043	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
439851007044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851007045	active site
439851007046	phosphorylation site [posttranslational modification]
439851007047	intermolecular recognition site; other site
439851007048	dimerization interface [polypeptide binding]; other site
439851007049	von Willebrand factor; Region: vWF_A; pfam12450
439851007050	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
439851007051	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
439851007052	metal ion-dependent adhesion site (MIDAS); other site
439851007053	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
439851007054	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
439851007055	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439851007056	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
439851007057	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439851007058	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
439851007059	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
439851007060	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439851007061	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
439851007062	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
439851007063	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
439851007064	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
439851007065	4Fe-4S binding domain; Region: Fer4; pfam00037
439851007066	4Fe-4S binding domain; Region: Fer4; pfam00037
439851007067	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
439851007068	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
439851007069	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439851007070	catalytic loop [active]
439851007071	iron binding site [ion binding]; other site
439851007072	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
439851007073	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
439851007074	[4Fe-4S] binding site [ion binding]; other site
439851007075	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
439851007076	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
439851007077	SLBB domain; Region: SLBB; pfam10531
439851007078	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
439851007079	NADH dehydrogenase subunit E; Validated; Region: PRK07539
439851007080	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
439851007081	putative dimer interface [polypeptide binding]; other site
439851007082	[2Fe-2S] cluster binding site [ion binding]; other site
439851007083	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
439851007084	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
439851007085	NADH dehydrogenase subunit D; Validated; Region: PRK06075
439851007086	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
439851007087	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
439851007088	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
439851007089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851007090	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
439851007091	putative dimerization interface [polypeptide binding]; other site
439851007092	5'-nucleotidase; Provisional; Region: PRK03826
439851007093	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
439851007094	transmembrane helices; other site
439851007095	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
439851007096	TrkA-C domain; Region: TrkA_C; pfam02080
439851007097	TrkA-C domain; Region: TrkA_C; pfam02080
439851007098	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
439851007099	putative phosphatase; Provisional; Region: PRK11587
439851007100	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851007101	motif II; other site
439851007102	hypothetical protein; Validated; Region: PRK05445
439851007103	hypothetical protein; Provisional; Region: PRK01816
439851007104	propionate/acetate kinase; Provisional; Region: PRK12379
439851007105	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
439851007106	phosphate acetyltransferase; Reviewed; Region: PRK05632
439851007107	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
439851007108	DRTGG domain; Region: DRTGG; pfam07085
439851007109	phosphate acetyltransferase; Region: pta; TIGR00651
439851007110	hypothetical protein; Provisional; Region: PRK11588
439851007111	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
439851007112	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
439851007113	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439851007114	PYR/PP interface [polypeptide binding]; other site
439851007115	dimer interface [polypeptide binding]; other site
439851007116	TPP binding site [chemical binding]; other site
439851007117	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439851007118	transketolase; Reviewed; Region: PRK05899
439851007119	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
439851007120	TPP-binding site [chemical binding]; other site
439851007121	dimer interface [polypeptide binding]; other site
439851007122	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
439851007123	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
439851007124	active site
439851007125	P-loop; other site
439851007126	phosphorylation site [posttranslational modification]
439851007127	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851007128	active site
439851007129	phosphorylation site [posttranslational modification]
439851007130	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439851007131	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851007132	DNA binding site [nucleotide binding]
439851007133	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
439851007134	putative dimerization interface [polypeptide binding]; other site
439851007135	putative ligand binding site [chemical binding]; other site
439851007136	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
439851007137	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
439851007138	nudix motif; other site
439851007139	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
439851007140	active site
439851007141	metal binding site [ion binding]; metal-binding site
439851007142	homotetramer interface [polypeptide binding]; other site
439851007143	glutathione S-transferase; Provisional; Region: PRK15113
439851007144	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
439851007145	C-terminal domain interface [polypeptide binding]; other site
439851007146	GSH binding site (G-site) [chemical binding]; other site
439851007147	dimer interface [polypeptide binding]; other site
439851007148	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
439851007149	N-terminal domain interface [polypeptide binding]; other site
439851007150	putative dimer interface [polypeptide binding]; other site
439851007151	putative substrate binding pocket (H-site) [chemical binding]; other site
439851007152	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
439851007153	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
439851007154	C-terminal domain interface [polypeptide binding]; other site
439851007155	GSH binding site (G-site) [chemical binding]; other site
439851007156	dimer interface [polypeptide binding]; other site
439851007157	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
439851007158	N-terminal domain interface [polypeptide binding]; other site
439851007159	putative dimer interface [polypeptide binding]; other site
439851007160	active site
439851007161	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
439851007162	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
439851007163	putative NAD(P) binding site [chemical binding]; other site
439851007164	putative active site [active]
439851007165	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
439851007166	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439851007167	Walker A/P-loop; other site
439851007168	ATP binding site [chemical binding]; other site
439851007169	Q-loop/lid; other site
439851007170	ABC transporter signature motif; other site
439851007171	Walker B; other site
439851007172	D-loop; other site
439851007173	H-loop/switch region; other site
439851007174	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851007175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851007176	dimer interface [polypeptide binding]; other site
439851007177	conserved gate region; other site
439851007178	putative PBP binding loops; other site
439851007179	ABC-ATPase subunit interface; other site
439851007180	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439851007181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851007182	dimer interface [polypeptide binding]; other site
439851007183	conserved gate region; other site
439851007184	putative PBP binding loops; other site
439851007185	ABC-ATPase subunit interface; other site
439851007186	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
439851007187	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851007188	substrate binding pocket [chemical binding]; other site
439851007189	membrane-bound complex binding site; other site
439851007190	hinge residues; other site
439851007191	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
439851007192	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851007193	substrate binding pocket [chemical binding]; other site
439851007194	membrane-bound complex binding site; other site
439851007195	hinge residues; other site
439851007196	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
439851007197	Flavoprotein; Region: Flavoprotein; pfam02441
439851007198	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
439851007199	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
439851007200	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
439851007201	dimer interface [polypeptide binding]; other site
439851007202	active site
439851007203	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439851007204	substrate binding site [chemical binding]; other site
439851007205	catalytic residue [active]
439851007206	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
439851007207	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
439851007208	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
439851007209	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439851007210	catalytic residue [active]
439851007211	PAS fold; Region: PAS_4; pfam08448
439851007212	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
439851007213	putative active site [active]
439851007214	heme pocket [chemical binding]; other site
439851007215	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
439851007216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851007217	Walker A motif; other site
439851007218	ATP binding site [chemical binding]; other site
439851007219	Walker B motif; other site
439851007220	arginine finger; other site
439851007221	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439851007222	amidophosphoribosyltransferase; Provisional; Region: PRK09246
439851007223	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
439851007224	active site
439851007225	tetramer interface [polypeptide binding]; other site
439851007226	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851007227	active site
439851007228	colicin V production protein; Provisional; Region: PRK10845
439851007229	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
439851007230	cell division protein DedD; Provisional; Region: PRK11633
439851007231	Sporulation related domain; Region: SPOR; pfam05036
439851007232	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
439851007233	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439851007234	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439851007235	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
439851007236	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
439851007237	hypothetical protein; Provisional; Region: PRK10847
439851007238	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439851007239	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
439851007240	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
439851007241	dimerization interface 3.5A [polypeptide binding]; other site
439851007242	active site
439851007243	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
439851007244	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
439851007245	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
439851007246	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
439851007247	ligand binding site [chemical binding]; other site
439851007248	NAD binding site [chemical binding]; other site
439851007249	catalytic site [active]
439851007250	homodimer interface [polypeptide binding]; other site
439851007251	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
439851007252	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
439851007253	CAAX protease self-immunity; Region: Abi; pfam02517
439851007254	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
439851007255	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
439851007256	dimer interface [polypeptide binding]; other site
439851007257	active site
439851007258	Uncharacterized conserved protein [Function unknown]; Region: COG4121
439851007259	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
439851007260	YfcL protein; Region: YfcL; pfam08891
439851007261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
439851007262	hypothetical protein; Provisional; Region: PRK10621
439851007263	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
439851007264	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
439851007265	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
439851007266	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
439851007267	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
439851007268	Tetramer interface [polypeptide binding]; other site
439851007269	active site
439851007270	FMN-binding site [chemical binding]; other site
439851007271	hypothetical protein; Provisional; Region: PRK04946
439851007272	Smr domain; Region: Smr; pfam01713
439851007273	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439851007274	catalytic core [active]
439851007275	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
439851007276	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439851007277	substrate binding site [chemical binding]; other site
439851007278	oxyanion hole (OAH) forming residues; other site
439851007279	trimer interface [polypeptide binding]; other site
439851007280	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
439851007281	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
439851007282	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
439851007283	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
439851007284	dimer interface [polypeptide binding]; other site
439851007285	active site
439851007286	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
439851007287	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
439851007288	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
439851007289	Predicted membrane protein [Function unknown]; Region: COG2246
439851007290	GtrA-like protein; Region: GtrA; pfam04138
439851007291	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
439851007292	outer membrane protease; Reviewed; Region: PRK10993
439851007293	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
439851007294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851007295	active site
439851007296	phosphorylation site [posttranslational modification]
439851007297	intermolecular recognition site; other site
439851007298	dimerization interface [polypeptide binding]; other site
439851007299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
439851007300	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439851007301	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
439851007302	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
439851007303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851007304	dimer interface [polypeptide binding]; other site
439851007305	phosphorylation site [posttranslational modification]
439851007306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851007307	ATP binding site [chemical binding]; other site
439851007308	Mg2+ binding site [ion binding]; other site
439851007309	G-X-G motif; other site
439851007310	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
439851007311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851007312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851007313	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
439851007314	aminotransferase; Validated; Region: PRK08175
439851007315	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851007316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851007317	homodimer interface [polypeptide binding]; other site
439851007318	catalytic residue [active]
439851007319	glucokinase; Provisional; Region: glk; PRK00292
439851007320	glucokinase, proteobacterial type; Region: glk; TIGR00749
439851007321	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
439851007322	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
439851007323	Cl- selectivity filter; other site
439851007324	Cl- binding residues [ion binding]; other site
439851007325	pore gating glutamate residue; other site
439851007326	dimer interface [polypeptide binding]; other site
439851007327	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851007328	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851007329	active site
439851007330	catalytic tetrad [active]
439851007331	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
439851007332	manganese transport protein MntH; Reviewed; Region: PRK00701
439851007333	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
439851007334	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
439851007335	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
439851007336	Nucleoside recognition; Region: Gate; pfam07670
439851007337	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
439851007338	MASE1; Region: MASE1; pfam05231
439851007339	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439851007340	diguanylate cyclase; Region: GGDEF; smart00267
439851007341	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851007342	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
439851007343	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
439851007344	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
439851007345	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
439851007346	active site
439851007347	HIGH motif; other site
439851007348	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
439851007349	active site
439851007350	KMSKS motif; other site
439851007351	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
439851007352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851007353	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
439851007354	putative dimerization interface [polypeptide binding]; other site
439851007355	putative substrate binding pocket [chemical binding]; other site
439851007356	XapX domain; Region: XapX; TIGR03510
439851007357	nucleoside transporter; Region: 2A0110; TIGR00889
439851007358	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851007359	putative substrate translocation pore; other site
439851007360	purine nucleoside phosphorylase; Provisional; Region: PRK08202
439851007361	hypothetical protein; Provisional; Region: PRK11528
439851007362	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851007363	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851007364	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
439851007365	putative dimerization interface [polypeptide binding]; other site
439851007366	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
439851007367	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
439851007368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
439851007369	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
439851007370	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
439851007371	nucleotide binding pocket [chemical binding]; other site
439851007372	K-X-D-G motif; other site
439851007373	catalytic site [active]
439851007374	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
439851007375	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
439851007376	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
439851007377	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
439851007378	Dimer interface [polypeptide binding]; other site
439851007379	BRCT sequence motif; other site
439851007380	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
439851007381	cell division protein ZipA; Provisional; Region: PRK03427
439851007382	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
439851007383	FtsZ protein binding site [polypeptide binding]; other site
439851007384	putative sulfate transport protein CysZ; Validated; Region: PRK04949
439851007385	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
439851007386	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
439851007387	dimer interface [polypeptide binding]; other site
439851007388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851007389	catalytic residue [active]
439851007390	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439851007391	dimerization domain swap beta strand [polypeptide binding]; other site
439851007392	regulatory protein interface [polypeptide binding]; other site
439851007393	active site
439851007394	regulatory phosphorylation site [posttranslational modification]; other site
439851007395	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
439851007396	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
439851007397	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
439851007398	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
439851007399	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
439851007400	HPr interaction site; other site
439851007401	glycerol kinase (GK) interaction site [polypeptide binding]; other site
439851007402	active site
439851007403	phosphorylation site [posttranslational modification]
439851007404	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
439851007405	dimer interface [polypeptide binding]; other site
439851007406	pyridoxamine kinase; Validated; Region: PRK05756
439851007407	pyridoxal binding site [chemical binding]; other site
439851007408	ATP binding site [chemical binding]; other site
439851007409	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
439851007410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851007411	DNA-binding site [nucleotide binding]; DNA binding site
439851007412	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851007413	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851007414	homodimer interface [polypeptide binding]; other site
439851007415	catalytic residue [active]
439851007416	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
439851007417	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
439851007418	catalytic triad [active]
439851007419	hypothetical protein; Provisional; Region: PRK10318
439851007420	Transglycosylase; Region: Transgly; cl17702
439851007421	cysteine synthase B; Region: cysM; TIGR01138
439851007422	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
439851007423	dimer interface [polypeptide binding]; other site
439851007424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851007425	catalytic residue [active]
439851007426	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
439851007427	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
439851007428	Walker A/P-loop; other site
439851007429	ATP binding site [chemical binding]; other site
439851007430	Q-loop/lid; other site
439851007431	ABC transporter signature motif; other site
439851007432	Walker B; other site
439851007433	D-loop; other site
439851007434	H-loop/switch region; other site
439851007435	TOBE-like domain; Region: TOBE_3; pfam12857
439851007436	sulfate transport protein; Provisional; Region: cysT; CHL00187
439851007437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851007438	dimer interface [polypeptide binding]; other site
439851007439	conserved gate region; other site
439851007440	putative PBP binding loops; other site
439851007441	ABC-ATPase subunit interface; other site
439851007442	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
439851007443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851007444	dimer interface [polypeptide binding]; other site
439851007445	conserved gate region; other site
439851007446	putative PBP binding loops; other site
439851007447	ABC-ATPase subunit interface; other site
439851007448	thiosulfate transporter subunit; Provisional; Region: PRK10852
439851007449	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
439851007450	short chain dehydrogenase; Provisional; Region: PRK08226
439851007451	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
439851007452	NAD binding site [chemical binding]; other site
439851007453	homotetramer interface [polypeptide binding]; other site
439851007454	homodimer interface [polypeptide binding]; other site
439851007455	active site
439851007456	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
439851007457	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
439851007458	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
439851007459	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
439851007460	putative acetyltransferase; Provisional; Region: PRK03624
439851007461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851007462	Coenzyme A binding pocket [chemical binding]; other site
439851007463	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
439851007464	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
439851007465	active site
439851007466	metal binding site [ion binding]; metal-binding site
439851007467	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
439851007468	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
439851007469	transcriptional regulator EutR; Provisional; Region: PRK10130
439851007470	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851007471	carboxysome structural protein EutK; Provisional; Region: PRK15466
439851007472	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
439851007473	Hexamer interface [polypeptide binding]; other site
439851007474	Hexagonal pore residue; other site
439851007475	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
439851007476	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
439851007477	putative hexamer interface [polypeptide binding]; other site
439851007478	putative hexagonal pore; other site
439851007479	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
439851007480	putative hexamer interface [polypeptide binding]; other site
439851007481	putative hexagonal pore; other site
439851007482	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
439851007483	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
439851007484	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
439851007485	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
439851007486	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
439851007487	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
439851007488	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
439851007489	active site
439851007490	metal binding site [ion binding]; metal-binding site
439851007491	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
439851007492	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851007493	nucleotide binding site [chemical binding]; other site
439851007494	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
439851007495	putative catalytic cysteine [active]
439851007496	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
439851007497	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
439851007498	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
439851007499	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
439851007500	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
439851007501	G1 box; other site
439851007502	GTP/Mg2+ binding site [chemical binding]; other site
439851007503	G2 box; other site
439851007504	Switch I region; other site
439851007505	G3 box; other site
439851007506	Switch II region; other site
439851007507	G4 box; other site
439851007508	G5 box; other site
439851007509	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
439851007510	putative hexamer interface [polypeptide binding]; other site
439851007511	putative hexagonal pore; other site
439851007512	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
439851007513	Malic enzyme, N-terminal domain; Region: malic; pfam00390
439851007514	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
439851007515	putative NAD(P) binding site [chemical binding]; other site
439851007516	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
439851007517	transaldolase-like protein; Provisional; Region: PTZ00411
439851007518	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
439851007519	active site
439851007520	dimer interface [polypeptide binding]; other site
439851007521	catalytic residue [active]
439851007522	transketolase; Reviewed; Region: PRK12753
439851007523	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
439851007524	TPP-binding site [chemical binding]; other site
439851007525	dimer interface [polypeptide binding]; other site
439851007526	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439851007527	PYR/PP interface [polypeptide binding]; other site
439851007528	dimer interface [polypeptide binding]; other site
439851007529	TPP binding site [chemical binding]; other site
439851007530	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439851007531	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
439851007532	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
439851007533	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
439851007534	dimer interface [polypeptide binding]; other site
439851007535	ADP-ribose binding site [chemical binding]; other site
439851007536	active site
439851007537	nudix motif; other site
439851007538	metal binding site [ion binding]; metal-binding site
439851007539	putative periplasmic esterase; Provisional; Region: PRK03642
439851007540	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
439851007541	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
439851007542	4Fe-4S binding domain; Region: Fer4; pfam00037
439851007543	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851007544	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851007545	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
439851007546	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
439851007547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851007548	dimerization interface [polypeptide binding]; other site
439851007549	Histidine kinase; Region: HisKA_3; pfam07730
439851007550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851007551	ATP binding site [chemical binding]; other site
439851007552	Mg2+ binding site [ion binding]; other site
439851007553	G-X-G motif; other site
439851007554	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
439851007555	Protein export membrane protein; Region: SecD_SecF; cl14618
439851007556	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
439851007557	ArsC family; Region: ArsC; pfam03960
439851007558	putative catalytic residues [active]
439851007559	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
439851007560	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
439851007561	metal binding site [ion binding]; metal-binding site
439851007562	dimer interface [polypeptide binding]; other site
439851007563	hypothetical protein; Provisional; Region: PRK13664
439851007564	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
439851007565	Helicase; Region: Helicase_RecD; pfam05127
439851007566	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851007567	Coenzyme A binding pocket [chemical binding]; other site
439851007568	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
439851007569	Predicted metalloprotease [General function prediction only]; Region: COG2321
439851007570	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
439851007571	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
439851007572	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
439851007573	ATP binding site [chemical binding]; other site
439851007574	active site
439851007575	substrate binding site [chemical binding]; other site
439851007576	lipoprotein; Provisional; Region: PRK11679
439851007577	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
439851007578	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
439851007579	dihydrodipicolinate synthase; Region: dapA; TIGR00674
439851007580	dimer interface [polypeptide binding]; other site
439851007581	active site
439851007582	catalytic residue [active]
439851007583	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
439851007584	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
439851007585	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
439851007586	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
439851007587	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
439851007588	catalytic triad [active]
439851007589	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
439851007590	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
439851007591	fructuronate transporter; Provisional; Region: PRK10034; cl15264
439851007592	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
439851007593	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
439851007594	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
439851007595	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
439851007596	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439851007597	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
439851007598	Peptidase family M48; Region: Peptidase_M48; cl12018
439851007599	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
439851007600	ArsC family; Region: ArsC; pfam03960
439851007601	catalytic residues [active]
439851007602	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
439851007603	DNA replication initiation factor; Provisional; Region: PRK08084
439851007604	uracil transporter; Provisional; Region: PRK10720
439851007605	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851007606	active site
439851007607	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
439851007608	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
439851007609	dimerization interface [polypeptide binding]; other site
439851007610	putative ATP binding site [chemical binding]; other site
439851007611	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
439851007612	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
439851007613	active site
439851007614	substrate binding site [chemical binding]; other site
439851007615	cosubstrate binding site; other site
439851007616	catalytic site [active]
439851007617	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
439851007618	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
439851007619	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
439851007620	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
439851007621	putative active site [active]
439851007622	catalytic site [active]
439851007623	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
439851007624	domain interface [polypeptide binding]; other site
439851007625	active site
439851007626	catalytic site [active]
439851007627	exopolyphosphatase; Provisional; Region: PRK10854
439851007628	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851007629	nucleotide binding site [chemical binding]; other site
439851007630	MASE1; Region: MASE1; pfam05231
439851007631	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439851007632	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
439851007633	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851007634	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
439851007635	GMP synthase; Reviewed; Region: guaA; PRK00074
439851007636	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
439851007637	AMP/PPi binding site [chemical binding]; other site
439851007638	candidate oxyanion hole; other site
439851007639	catalytic triad [active]
439851007640	potential glutamine specificity residues [chemical binding]; other site
439851007641	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
439851007642	ATP Binding subdomain [chemical binding]; other site
439851007643	Ligand Binding sites [chemical binding]; other site
439851007644	Dimerization subdomain; other site
439851007645	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
439851007646	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
439851007647	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
439851007648	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
439851007649	active site
439851007650	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
439851007651	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
439851007652	generic binding surface II; other site
439851007653	generic binding surface I; other site
439851007654	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
439851007655	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439851007656	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
439851007657	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439851007658	intimin-like protein SinH; Provisional; Region: PRK15318
439851007659	intimin-like protein SinH; Provisional; Region: PRK15318
439851007660	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
439851007661	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
439851007662	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
439851007663	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
439851007664	Trp docking motif [polypeptide binding]; other site
439851007665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
439851007666	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
439851007667	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
439851007668	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
439851007669	dimer interface [polypeptide binding]; other site
439851007670	motif 1; other site
439851007671	active site
439851007672	motif 2; other site
439851007673	motif 3; other site
439851007674	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
439851007675	anticodon binding site; other site
439851007676	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
439851007677	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
439851007678	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
439851007679	cytoskeletal protein RodZ; Provisional; Region: PRK10856
439851007680	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851007681	non-specific DNA binding site [nucleotide binding]; other site
439851007682	salt bridge; other site
439851007683	sequence-specific DNA binding site [nucleotide binding]; other site
439851007684	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
439851007685	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
439851007686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851007687	FeS/SAM binding site; other site
439851007688	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
439851007689	active site
439851007690	multimer interface [polypeptide binding]; other site
439851007691	4Fe-4S binding domain; Region: Fer4; pfam00037
439851007692	hydrogenase 4 subunit H; Validated; Region: PRK08222
439851007693	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
439851007694	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439851007695	4Fe-4S binding domain; Region: Fer4; pfam00037
439851007696	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439851007697	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439851007698	putative [Fe4-S4] binding site [ion binding]; other site
439851007699	putative molybdopterin cofactor binding site [chemical binding]; other site
439851007700	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439851007701	putative molybdopterin cofactor binding site; other site
439851007702	penicillin-binding protein 1C; Provisional; Region: PRK11240
439851007703	Transglycosylase; Region: Transgly; pfam00912
439851007704	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
439851007705	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
439851007706	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
439851007707	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
439851007708	active site residue [active]
439851007709	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
439851007710	active site residue [active]
439851007711	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
439851007712	aminopeptidase B; Provisional; Region: PRK05015
439851007713	Peptidase; Region: DUF3663; pfam12404
439851007714	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
439851007715	interface (dimer of trimers) [polypeptide binding]; other site
439851007716	Substrate-binding/catalytic site; other site
439851007717	Zn-binding sites [ion binding]; other site
439851007718	hypothetical protein; Provisional; Region: PRK10721
439851007719	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
439851007720	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439851007721	catalytic loop [active]
439851007722	iron binding site [ion binding]; other site
439851007723	chaperone protein HscA; Provisional; Region: hscA; PRK05183
439851007724	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
439851007725	nucleotide binding site [chemical binding]; other site
439851007726	putative NEF/HSP70 interaction site [polypeptide binding]; other site
439851007727	SBD interface [polypeptide binding]; other site
439851007728	co-chaperone HscB; Provisional; Region: hscB; PRK05014
439851007729	DnaJ domain; Region: DnaJ; pfam00226
439851007730	HSP70 interaction site [polypeptide binding]; other site
439851007731	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
439851007732	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
439851007733	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
439851007734	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
439851007735	trimerization site [polypeptide binding]; other site
439851007736	active site
439851007737	cysteine desulfurase; Provisional; Region: PRK14012
439851007738	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
439851007739	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851007740	catalytic residue [active]
439851007741	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
439851007742	Rrf2 family protein; Region: rrf2_super; TIGR00738
439851007743	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
439851007744	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
439851007745	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
439851007746	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
439851007747	active site
439851007748	dimerization interface [polypeptide binding]; other site
439851007749	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
439851007750	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
439851007751	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
439851007752	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439851007753	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
439851007754	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
439851007755	FAD binding pocket [chemical binding]; other site
439851007756	FAD binding motif [chemical binding]; other site
439851007757	phosphate binding motif [ion binding]; other site
439851007758	beta-alpha-beta structure motif; other site
439851007759	NAD binding pocket [chemical binding]; other site
439851007760	Iron coordination center [ion binding]; other site
439851007761	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
439851007762	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439851007763	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439851007764	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
439851007765	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
439851007766	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
439851007767	PRD domain; Region: PRD; pfam00874
439851007768	PRD domain; Region: PRD; pfam00874
439851007769	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
439851007770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851007771	putative substrate translocation pore; other site
439851007772	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
439851007773	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
439851007774	dimer interface [polypeptide binding]; other site
439851007775	active site
439851007776	glycine-pyridoxal phosphate binding site [chemical binding]; other site
439851007777	folate binding site [chemical binding]; other site
439851007778	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
439851007779	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
439851007780	heme-binding site [chemical binding]; other site
439851007781	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
439851007782	FAD binding pocket [chemical binding]; other site
439851007783	FAD binding motif [chemical binding]; other site
439851007784	phosphate binding motif [ion binding]; other site
439851007785	beta-alpha-beta structure motif; other site
439851007786	NAD binding pocket [chemical binding]; other site
439851007787	Heme binding  pocket [chemical binding]; other site
439851007788	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
439851007789	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851007790	DNA binding site [nucleotide binding]
439851007791	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
439851007792	lysine decarboxylase CadA; Provisional; Region: PRK15400
439851007793	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439851007794	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439851007795	homodimer interface [polypeptide binding]; other site
439851007796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851007797	catalytic residue [active]
439851007798	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439851007799	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
439851007800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851007801	putative substrate translocation pore; other site
439851007802	POT family; Region: PTR2; pfam00854
439851007803	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
439851007804	Nitrogen regulatory protein P-II; Region: P-II; smart00938
439851007805	response regulator GlrR; Provisional; Region: PRK15115
439851007806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851007807	active site
439851007808	phosphorylation site [posttranslational modification]
439851007809	intermolecular recognition site; other site
439851007810	dimerization interface [polypeptide binding]; other site
439851007811	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851007812	Walker A motif; other site
439851007813	ATP binding site [chemical binding]; other site
439851007814	Walker B motif; other site
439851007815	arginine finger; other site
439851007816	hypothetical protein; Provisional; Region: PRK10722
439851007817	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
439851007818	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
439851007819	dimerization interface [polypeptide binding]; other site
439851007820	ATP binding site [chemical binding]; other site
439851007821	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
439851007822	dimerization interface [polypeptide binding]; other site
439851007823	ATP binding site [chemical binding]; other site
439851007824	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
439851007825	putative active site [active]
439851007826	catalytic triad [active]
439851007827	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
439851007828	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851007829	substrate binding pocket [chemical binding]; other site
439851007830	membrane-bound complex binding site; other site
439851007831	hinge residues; other site
439851007832	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439851007833	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851007834	catalytic residue [active]
439851007835	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
439851007836	nucleoside/Zn binding site; other site
439851007837	dimer interface [polypeptide binding]; other site
439851007838	catalytic motif [active]
439851007839	hypothetical protein; Provisional; Region: PRK11590
439851007840	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
439851007841	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
439851007842	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439851007843	active site turn [active]
439851007844	phosphorylation site [posttranslational modification]
439851007845	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439851007846	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
439851007847	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
439851007848	putative active site [active]
439851007849	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
439851007850	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
439851007851	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
439851007852	putative active site [active]
439851007853	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
439851007854	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
439851007855	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
439851007856	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
439851007857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851007858	putative substrate translocation pore; other site
439851007859	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851007860	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851007861	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851007862	dimerization interface [polypeptide binding]; other site
439851007863	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
439851007864	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
439851007865	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
439851007866	active site
439851007867	hydrophilic channel; other site
439851007868	dimerization interface [polypeptide binding]; other site
439851007869	catalytic residues [active]
439851007870	active site lid [active]
439851007871	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
439851007872	Recombination protein O N terminal; Region: RecO_N; pfam11967
439851007873	Recombination protein O C terminal; Region: RecO_C; pfam02565
439851007874	GTPase Era; Reviewed; Region: era; PRK00089
439851007875	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
439851007876	G1 box; other site
439851007877	GTP/Mg2+ binding site [chemical binding]; other site
439851007878	Switch I region; other site
439851007879	G2 box; other site
439851007880	Switch II region; other site
439851007881	G3 box; other site
439851007882	G4 box; other site
439851007883	G5 box; other site
439851007884	KH domain; Region: KH_2; pfam07650
439851007885	ribonuclease III; Reviewed; Region: rnc; PRK00102
439851007886	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
439851007887	dimerization interface [polypeptide binding]; other site
439851007888	active site
439851007889	metal binding site [ion binding]; metal-binding site
439851007890	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
439851007891	dsRNA binding site [nucleotide binding]; other site
439851007892	rncO
439851007893	signal peptidase I; Provisional; Region: PRK10861
439851007894	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
439851007895	Catalytic site [active]
439851007896	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
439851007897	GTP-binding protein LepA; Provisional; Region: PRK05433
439851007898	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
439851007899	G1 box; other site
439851007900	putative GEF interaction site [polypeptide binding]; other site
439851007901	GTP/Mg2+ binding site [chemical binding]; other site
439851007902	Switch I region; other site
439851007903	G2 box; other site
439851007904	G3 box; other site
439851007905	Switch II region; other site
439851007906	G4 box; other site
439851007907	G5 box; other site
439851007908	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
439851007909	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
439851007910	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
439851007911	SoxR reducing system protein RseC; Provisional; Region: PRK10862
439851007912	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
439851007913	anti-sigma E factor; Provisional; Region: rseB; PRK09455
439851007914	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
439851007915	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
439851007916	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
439851007917	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
439851007918	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439851007919	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439851007920	DNA binding residues [nucleotide binding]
439851007921	L-aspartate oxidase; Provisional; Region: PRK09077
439851007922	L-aspartate oxidase; Provisional; Region: PRK06175
439851007923	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
439851007924	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
439851007925	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439851007926	ATP binding site [chemical binding]; other site
439851007927	Mg++ binding site [ion binding]; other site
439851007928	motif III; other site
439851007929	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851007930	nucleotide binding region [chemical binding]; other site
439851007931	ATP-binding site [chemical binding]; other site
439851007932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851007933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851007934	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851007935	dimerization interface [polypeptide binding]; other site
439851007936	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
439851007937	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
439851007938	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
439851007939	ligand binding site [chemical binding]; other site
439851007940	active site
439851007941	UGI interface [polypeptide binding]; other site
439851007942	catalytic site [active]
439851007943	putative methyltransferase; Provisional; Region: PRK10864
439851007944	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
439851007945	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
439851007946	thioredoxin 2; Provisional; Region: PRK10996
439851007947	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
439851007948	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
439851007949	catalytic residues [active]
439851007950	Uncharacterized conserved protein [Function unknown]; Region: COG3148
439851007951	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
439851007952	CoA binding domain; Region: CoA_binding_2; pfam13380
439851007953	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
439851007954	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
439851007955	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
439851007956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851007957	Coenzyme A binding pocket [chemical binding]; other site
439851007958	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
439851007959	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
439851007960	domain interface [polypeptide binding]; other site
439851007961	putative active site [active]
439851007962	catalytic site [active]
439851007963	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
439851007964	domain interface [polypeptide binding]; other site
439851007965	putative active site [active]
439851007966	catalytic site [active]
439851007967	lipoprotein; Provisional; Region: PRK10759
439851007968	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
439851007969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851007970	putative substrate translocation pore; other site
439851007971	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
439851007972	protein disaggregation chaperone; Provisional; Region: PRK10865
439851007973	Clp amino terminal domain; Region: Clp_N; pfam02861
439851007974	Clp amino terminal domain; Region: Clp_N; pfam02861
439851007975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851007976	Walker A motif; other site
439851007977	ATP binding site [chemical binding]; other site
439851007978	Walker B motif; other site
439851007979	arginine finger; other site
439851007980	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851007981	Walker A motif; other site
439851007982	ATP binding site [chemical binding]; other site
439851007983	Walker B motif; other site
439851007984	arginine finger; other site
439851007985	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
439851007986	hypothetical protein; Provisional; Region: PRK10723
439851007987	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
439851007988	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
439851007989	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851007990	RNA binding surface [nucleotide binding]; other site
439851007991	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
439851007992	active site
439851007993	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
439851007994	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
439851007995	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
439851007996	30S subunit binding site; other site
439851007997	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
439851007998	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
439851007999	Prephenate dehydratase; Region: PDT; pfam00800
439851008000	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
439851008001	putative L-Phe binding site [chemical binding]; other site
439851008002	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
439851008003	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
439851008004	Chorismate mutase type II; Region: CM_2; cl00693
439851008005	prephenate dehydrogenase; Validated; Region: PRK08507
439851008006	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
439851008007	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439851008008	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
439851008009	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
439851008010	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851008011	metal binding site [ion binding]; metal-binding site
439851008012	active site
439851008013	I-site; other site
439851008014	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
439851008015	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
439851008016	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
439851008017	RimM N-terminal domain; Region: RimM; pfam01782
439851008018	PRC-barrel domain; Region: PRC; pfam05239
439851008019	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
439851008020	signal recognition particle protein; Provisional; Region: PRK10867
439851008021	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
439851008022	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
439851008023	P loop; other site
439851008024	GTP binding site [chemical binding]; other site
439851008025	Signal peptide binding domain; Region: SRP_SPB; pfam02978
439851008026	hypothetical protein; Provisional; Region: PRK11573
439851008027	Domain of unknown function DUF21; Region: DUF21; pfam01595
439851008028	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439851008029	Transporter associated domain; Region: CorC_HlyC; smart01091
439851008030	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
439851008031	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
439851008032	dimer interface [polypeptide binding]; other site
439851008033	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
439851008034	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
439851008035	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
439851008036	recombination and repair protein; Provisional; Region: PRK10869
439851008037	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
439851008038	Walker A/P-loop; other site
439851008039	ATP binding site [chemical binding]; other site
439851008040	Q-loop/lid; other site
439851008041	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
439851008042	ABC transporter signature motif; other site
439851008043	Walker B; other site
439851008044	D-loop; other site
439851008045	H-loop/switch region; other site
439851008046	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
439851008047	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
439851008048	hypothetical protein; Validated; Region: PRK01777
439851008049	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
439851008050	putative coenzyme Q binding site [chemical binding]; other site
439851008051	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
439851008052	SmpB-tmRNA interface; other site
439851008053	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008054	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008055	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008056	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008057	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008058	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008059	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008060	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008061	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008062	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008063	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008064	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851008065	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008066	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008067	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851008068	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008069	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851008070	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
439851008071	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
439851008072	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
439851008073	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851008074	tail protein; Provisional; Region: D; PHA02561
439851008075	Phage protein U [General function prediction only]; Region: COG3499
439851008076	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
439851008077	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
439851008078	major tail tube protein; Provisional; Region: FII; PHA02600
439851008079	major tail sheath protein; Provisional; Region: FI; PHA02560
439851008080	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439851008081	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
439851008082	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
439851008083	Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903
439851008084	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
439851008085	baseplate assembly protein; Provisional; Region: J; PHA02568
439851008086	baseplate wedge subunit; Provisional; Region: W; PHA02516
439851008087	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
439851008088	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
439851008089	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
439851008090	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
439851008091	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
439851008092	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
439851008093	catalytic residues [active]
439851008094	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
439851008095	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
439851008096	terminase endonuclease subunit; Provisional; Region: M; PHA02537
439851008097	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
439851008098	capsid protein; Provisional; Region: N; PHA02538
439851008099	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
439851008100	terminase ATPase subunit; Provisional; Region: P; PHA02535
439851008101	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
439851008102	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
439851008103	portal vertex protein; Provisional; Region: Q; PHA02536
439851008104	Phage portal protein; Region: Phage_portal; pfam04860
439851008105	Protein of unknown function DUF262; Region: DUF262; pfam03235
439851008106	Uncharacterized conserved protein [Function unknown]; Region: COG1479
439851008107	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
439851008108	DNA adenine methylase (dam); Region: dam; TIGR00571
439851008109	DksA-like zinc finger domain containing protein; Region: PHA00080
439851008110	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
439851008111	Predicted transcriptional regulator [Transcription]; Region: COG2932
439851008112	integrase; Provisional; Region: int; PHA02601
439851008113	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439851008114	active site
439851008115	DNA binding site [nucleotide binding]
439851008116	Int/Topo IB signature motif; other site
439851008117	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
439851008118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
439851008119	Integrase core domain; Region: rve; pfam00665
439851008120	Integrase core domain; Region: rve_3; pfam13683
439851008121	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439851008122	DNA-binding interface [nucleotide binding]; DNA binding site
439851008123	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
439851008124	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
439851008125	homodimer interface [polypeptide binding]; other site
439851008126	active site
439851008127	TDP-binding site; other site
439851008128	acceptor substrate-binding pocket; other site
439851008129	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439851008130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851008131	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
439851008132	Walker A/P-loop; other site
439851008133	ATP binding site [chemical binding]; other site
439851008134	Q-loop/lid; other site
439851008135	ABC transporter signature motif; other site
439851008136	Walker B; other site
439851008137	D-loop; other site
439851008138	H-loop/switch region; other site
439851008139	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
439851008140	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439851008141	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851008142	Walker A/P-loop; other site
439851008143	ATP binding site [chemical binding]; other site
439851008144	Q-loop/lid; other site
439851008145	ABC transporter signature motif; other site
439851008146	Walker B; other site
439851008147	D-loop; other site
439851008148	H-loop/switch region; other site
439851008149	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
439851008150	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
439851008151	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
439851008152	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
439851008153	outer membrane receptor FepA; Provisional; Region: PRK13528
439851008154	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851008155	N-terminal plug; other site
439851008156	ligand-binding site [chemical binding]; other site
439851008157	secreted effector protein PipB2; Provisional; Region: PRK15196
439851008158	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851008159	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851008160	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851008161	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851008162	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439851008163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
439851008164	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
439851008165	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
439851008166	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
439851008167	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
439851008168	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
439851008169	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
439851008170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851008171	dimer interface [polypeptide binding]; other site
439851008172	phosphorylation site [posttranslational modification]
439851008173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851008174	ATP binding site [chemical binding]; other site
439851008175	Mg2+ binding site [ion binding]; other site
439851008176	G-X-G motif; other site
439851008177	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
439851008178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851008179	active site
439851008180	phosphorylation site [posttranslational modification]
439851008181	intermolecular recognition site; other site
439851008182	dimerization interface [polypeptide binding]; other site
439851008183	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851008184	DNA binding site [nucleotide binding]
439851008185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
439851008186	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
439851008187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
439851008188	Predicted dehydrogenase [General function prediction only]; Region: COG0579
439851008189	hydroxyglutarate oxidase; Provisional; Region: PRK11728
439851008190	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
439851008191	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
439851008192	tetramerization interface [polypeptide binding]; other site
439851008193	NAD(P) binding site [chemical binding]; other site
439851008194	catalytic residues [active]
439851008195	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
439851008196	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
439851008197	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851008198	DNA-binding site [nucleotide binding]; DNA binding site
439851008199	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439851008200	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
439851008201	bacterial OsmY and nodulation domain; Region: BON; smart00749
439851008202	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851008203	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
439851008204	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439851008205	dimerization interface [polypeptide binding]; other site
439851008206	putative DNA binding site [nucleotide binding]; other site
439851008207	Transcriptional regulators [Transcription]; Region: MarR; COG1846
439851008208	putative Zn2+ binding site [ion binding]; other site
439851008209	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
439851008210	active site residue [active]
439851008211	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
439851008212	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
439851008213	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
439851008214	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
439851008215	hypothetical protein; Provisional; Region: PRK10556
439851008216	hypothetical protein; Provisional; Region: PRK10132
439851008217	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
439851008218	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851008219	DNA-binding site [nucleotide binding]; DNA binding site
439851008220	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851008221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851008222	homodimer interface [polypeptide binding]; other site
439851008223	catalytic residue [active]
439851008224	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
439851008225	Uncharacterized conserved protein [Function unknown]; Region: COG2128
439851008226	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
439851008227	catalytic residues [active]
439851008228	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
439851008229	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
439851008230	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
439851008231	Class I ribonucleotide reductase; Region: RNR_I; cd01679
439851008232	active site
439851008233	dimer interface [polypeptide binding]; other site
439851008234	catalytic residues [active]
439851008235	effector binding site; other site
439851008236	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
439851008237	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
439851008238	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
439851008239	dimer interface [polypeptide binding]; other site
439851008240	putative radical transfer pathway; other site
439851008241	diiron center [ion binding]; other site
439851008242	tyrosyl radical; other site
439851008243	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
439851008244	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
439851008245	Walker A/P-loop; other site
439851008246	ATP binding site [chemical binding]; other site
439851008247	Q-loop/lid; other site
439851008248	ABC transporter signature motif; other site
439851008249	Walker B; other site
439851008250	D-loop; other site
439851008251	H-loop/switch region; other site
439851008252	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
439851008253	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
439851008254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851008255	dimer interface [polypeptide binding]; other site
439851008256	conserved gate region; other site
439851008257	putative PBP binding loops; other site
439851008258	ABC-ATPase subunit interface; other site
439851008259	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
439851008260	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
439851008261	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
439851008262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008263	transcriptional repressor MprA; Provisional; Region: PRK10870
439851008264	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
439851008265	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
439851008266	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851008267	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851008268	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
439851008269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008270	putative substrate translocation pore; other site
439851008271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008272	S-ribosylhomocysteinase; Provisional; Region: PRK02260
439851008273	glutamate--cysteine ligase; Provisional; Region: PRK02107
439851008274	Predicted membrane protein [Function unknown]; Region: COG1238
439851008275	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
439851008276	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851008277	motif II; other site
439851008278	carbon storage regulator; Provisional; Region: PRK01712
439851008279	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
439851008280	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
439851008281	motif 1; other site
439851008282	active site
439851008283	motif 2; other site
439851008284	motif 3; other site
439851008285	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
439851008286	DHHA1 domain; Region: DHHA1; pfam02272
439851008287	recombination regulator RecX; Reviewed; Region: recX; PRK00117
439851008288	recombinase A; Provisional; Region: recA; PRK09354
439851008289	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
439851008290	hexamer interface [polypeptide binding]; other site
439851008291	Walker A motif; other site
439851008292	ATP binding site [chemical binding]; other site
439851008293	Walker B motif; other site
439851008294	hypothetical protein; Validated; Region: PRK03661
439851008295	Transglycosylase SLT domain; Region: SLT_2; pfam13406
439851008296	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439851008297	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851008298	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
439851008299	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
439851008300	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
439851008301	Nucleoside recognition; Region: Gate; pfam07670
439851008302	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
439851008303	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
439851008304	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
439851008305	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
439851008306	putative NAD(P) binding site [chemical binding]; other site
439851008307	active site
439851008308	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
439851008309	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
439851008310	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439851008311	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851008312	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
439851008313	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
439851008314	putative active site [active]
439851008315	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
439851008316	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
439851008317	GAF domain; Region: GAF; pfam01590
439851008318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851008319	Walker A motif; other site
439851008320	ATP binding site [chemical binding]; other site
439851008321	Walker B motif; other site
439851008322	arginine finger; other site
439851008323	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
439851008324	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
439851008325	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
439851008326	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
439851008327	iron binding site [ion binding]; other site
439851008328	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
439851008329	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851008330	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851008331	Acylphosphatase; Region: Acylphosphatase; pfam00708
439851008332	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
439851008333	HypF finger; Region: zf-HYPF; pfam07503
439851008334	HypF finger; Region: zf-HYPF; pfam07503
439851008335	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
439851008336	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
439851008337	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
439851008338	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
439851008339	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
439851008340	nickel binding site [ion binding]; other site
439851008341	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
439851008342	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
439851008343	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
439851008344	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439851008345	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
439851008346	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
439851008347	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
439851008348	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
439851008349	NADH dehydrogenase; Region: NADHdh; cl00469
439851008350	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
439851008351	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439851008352	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
439851008353	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
439851008354	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
439851008355	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
439851008356	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
439851008357	hydrogenase assembly chaperone; Provisional; Region: PRK10409
439851008358	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
439851008359	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
439851008360	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
439851008361	dimerization interface [polypeptide binding]; other site
439851008362	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
439851008363	ATP binding site [chemical binding]; other site
439851008364	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
439851008365	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
439851008366	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
439851008367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851008368	Walker A motif; other site
439851008369	ATP binding site [chemical binding]; other site
439851008370	Walker B motif; other site
439851008371	arginine finger; other site
439851008372	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439851008373	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
439851008374	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
439851008375	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
439851008376	metal binding site [ion binding]; metal-binding site
439851008377	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
439851008378	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
439851008379	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
439851008380	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851008381	ABC-ATPase subunit  interface; other site
439851008382	dimer interface [polypeptide binding]; other site
439851008383	putative PBP binding regions; other site
439851008384	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
439851008385	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439851008386	ABC-ATPase subunit  interface; other site
439851008387	dimer interface [polypeptide binding]; other site
439851008388	putative PBP binding regions; other site
439851008389	transcriptional activator SprB; Provisional; Region: PRK15320
439851008390	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
439851008391	transcriptional regulator SirC; Provisional; Region: PRK15044
439851008392	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851008393	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
439851008394	invasion protein OrgB; Provisional; Region: PRK15322
439851008395	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
439851008396	invasion protein OrgA; Provisional; Region: PRK15323
439851008397	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
439851008398	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
439851008399	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
439851008400	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
439851008401	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
439851008402	transcriptional regulator HilD; Provisional; Region: PRK15185
439851008403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851008404	invasion protein regulator; Provisional; Region: PRK12370
439851008405	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851008406	DNA binding site [nucleotide binding]
439851008407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439851008408	binding surface
439851008409	TPR motif; other site
439851008410	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
439851008411	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439851008412	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851008413	catalytic residue [active]
439851008414	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
439851008415	SicP binding; Region: SicP-binding; pfam09119
439851008416	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
439851008417	switch II binding region; other site
439851008418	Rac1 P-loop interaction site [polypeptide binding]; other site
439851008419	GTP binding residues [chemical binding]; other site
439851008420	switch I binding region; other site
439851008421	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
439851008422	active site
439851008423	chaperone protein SicP; Provisional; Region: PRK15329
439851008424	putative acyl carrier protein IacP; Validated; Region: PRK08172
439851008425	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
439851008426	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
439851008427	chaperone protein SicA; Provisional; Region: PRK15331
439851008428	Tetratricopeptide repeat; Region: TPR_3; pfam07720
439851008429	Tetratricopeptide repeat; Region: TPR_3; pfam07720
439851008430	type III secretion system protein SpaS; Validated; Region: PRK08156
439851008431	type III secretion system protein SpaR; Provisional; Region: PRK15332
439851008432	type III secretion system protein SpaQ; Provisional; Region: PRK15333
439851008433	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
439851008434	type III secretion system protein SpaO; Validated; Region: PRK08158
439851008435	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
439851008436	antigen presentation protein SpaN; Provisional; Region: PRK15334
439851008437	Surface presentation of antigens protein; Region: SPAN; pfam02510
439851008438	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
439851008439	ATP synthase SpaL; Validated; Region: PRK08149
439851008440	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
439851008441	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
439851008442	Walker A motif; other site
439851008443	ATP binding site [chemical binding]; other site
439851008444	Walker B motif; other site
439851008445	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
439851008446	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
439851008447	type III secretion system protein InvA; Provisional; Region: PRK15337
439851008448	type III secretion system regulator InvE; Provisional; Region: PRK15338
439851008449	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
439851008450	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
439851008451	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
439851008452	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
439851008453	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
439851008454	transcriptional regulator InvF; Provisional; Region: PRK15340
439851008455	InvH outer membrane lipoprotein; Region: InvH; pfam04741
439851008456	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
439851008457	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
439851008458	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439851008459	active site
439851008460	metal binding site [ion binding]; metal-binding site
439851008461	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
439851008462	MutS domain I; Region: MutS_I; pfam01624
439851008463	MutS domain II; Region: MutS_II; pfam05188
439851008464	MutS domain III; Region: MutS_III; pfam05192
439851008465	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
439851008466	Walker A/P-loop; other site
439851008467	ATP binding site [chemical binding]; other site
439851008468	Q-loop/lid; other site
439851008469	ABC transporter signature motif; other site
439851008470	Walker B; other site
439851008471	D-loop; other site
439851008472	H-loop/switch region; other site
439851008473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
439851008474	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008475	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439851008476	putative substrate translocation pore; other site
439851008477	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851008478	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851008479	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
439851008480	putative effector binding pocket; other site
439851008481	dimerization interface [polypeptide binding]; other site
439851008482	GntP family permease; Region: GntP_permease; pfam02447
439851008483	fructuronate transporter; Provisional; Region: PRK10034; cl15264
439851008484	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
439851008485	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
439851008486	putative NAD(P) binding site [chemical binding]; other site
439851008487	active site
439851008488	putative substrate binding site [chemical binding]; other site
439851008489	putative aldolase; Validated; Region: PRK08130
439851008490	intersubunit interface [polypeptide binding]; other site
439851008491	active site
439851008492	Zn2+ binding site [ion binding]; other site
439851008493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
439851008494	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
439851008495	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439851008496	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851008497	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851008498	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851008499	MarR family; Region: MarR_2; cl17246
439851008500	Transcriptional regulators [Transcription]; Region: MarR; COG1846
439851008501	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
439851008502	Flavoprotein; Region: Flavoprotein; pfam02441
439851008503	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
439851008504	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
439851008505	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
439851008506	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439851008507	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
439851008508	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439851008509	DNA binding residues [nucleotide binding]
439851008510	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
439851008511	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851008512	Peptidase family M23; Region: Peptidase_M23; pfam01551
439851008513	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
439851008514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851008515	S-adenosylmethionine binding site [chemical binding]; other site
439851008516	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
439851008517	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
439851008518	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
439851008519	Permutation of conserved domain; other site
439851008520	active site
439851008521	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
439851008522	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
439851008523	homotrimer interaction site [polypeptide binding]; other site
439851008524	zinc binding site [ion binding]; other site
439851008525	CDP-binding sites; other site
439851008526	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
439851008527	substrate binding site; other site
439851008528	dimer interface; other site
439851008529	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
439851008530	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
439851008531	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
439851008532	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
439851008533	ligand-binding site [chemical binding]; other site
439851008534	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
439851008535	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
439851008536	CysD dimerization site [polypeptide binding]; other site
439851008537	G1 box; other site
439851008538	putative GEF interaction site [polypeptide binding]; other site
439851008539	GTP/Mg2+ binding site [chemical binding]; other site
439851008540	Switch I region; other site
439851008541	G2 box; other site
439851008542	G3 box; other site
439851008543	Switch II region; other site
439851008544	G4 box; other site
439851008545	G5 box; other site
439851008546	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
439851008547	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
439851008548	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
439851008549	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
439851008550	Active Sites [active]
439851008551	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
439851008552	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
439851008553	metal binding site [ion binding]; metal-binding site
439851008554	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
439851008555	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
439851008556	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
439851008557	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
439851008558	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
439851008559	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
439851008560	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
439851008561	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
439851008562	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
439851008563	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
439851008564	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
439851008565	Active Sites [active]
439851008566	sulfite reductase subunit beta; Provisional; Region: PRK13504
439851008567	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439851008568	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439851008569	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
439851008570	Flavodoxin; Region: Flavodoxin_1; pfam00258
439851008571	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
439851008572	FAD binding pocket [chemical binding]; other site
439851008573	FAD binding motif [chemical binding]; other site
439851008574	catalytic residues [active]
439851008575	NAD binding pocket [chemical binding]; other site
439851008576	phosphate binding motif [ion binding]; other site
439851008577	beta-alpha-beta structure motif; other site
439851008578	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
439851008579	active site
439851008580	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
439851008581	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
439851008582	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
439851008583	enolase; Provisional; Region: eno; PRK00077
439851008584	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
439851008585	dimer interface [polypeptide binding]; other site
439851008586	metal binding site [ion binding]; metal-binding site
439851008587	substrate binding pocket [chemical binding]; other site
439851008588	CTP synthetase; Validated; Region: pyrG; PRK05380
439851008589	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
439851008590	Catalytic site [active]
439851008591	active site
439851008592	UTP binding site [chemical binding]; other site
439851008593	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
439851008594	active site
439851008595	putative oxyanion hole; other site
439851008596	catalytic triad [active]
439851008597	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
439851008598	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
439851008599	homodimer interface [polypeptide binding]; other site
439851008600	metal binding site [ion binding]; metal-binding site
439851008601	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
439851008602	homodimer interface [polypeptide binding]; other site
439851008603	active site
439851008604	putative chemical substrate binding site [chemical binding]; other site
439851008605	metal binding site [ion binding]; metal-binding site
439851008606	fimbrial protein SteA; Provisional; Region: PRK15261
439851008607	putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273
439851008608	PapC N-terminal domain; Region: PapC_N; pfam13954
439851008609	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851008610	PapC C-terminal domain; Region: PapC_C; pfam13953
439851008611	putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274
439851008612	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851008613	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851008614	putative fimbrial protein SteD; Provisional; Region: PRK15275
439851008615	putative fimbrial subunit SteE; Provisional; Region: PRK15276
439851008616	fimbrial protein SteF; Provisional; Region: PRK15260
439851008617	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
439851008618	HD domain; Region: HD_4; pfam13328
439851008619	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
439851008620	synthetase active site [active]
439851008621	NTP binding site [chemical binding]; other site
439851008622	metal binding site [ion binding]; metal-binding site
439851008623	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
439851008624	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
439851008625	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
439851008626	TRAM domain; Region: TRAM; pfam01938
439851008627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851008628	S-adenosylmethionine binding site [chemical binding]; other site
439851008629	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
439851008630	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
439851008631	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851008632	dimerization interface [polypeptide binding]; other site
439851008633	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851008634	dimer interface [polypeptide binding]; other site
439851008635	phosphorylation site [posttranslational modification]
439851008636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851008637	ATP binding site [chemical binding]; other site
439851008638	Mg2+ binding site [ion binding]; other site
439851008639	G-X-G motif; other site
439851008640	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
439851008641	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851008642	active site
439851008643	phosphorylation site [posttranslational modification]
439851008644	intermolecular recognition site; other site
439851008645	dimerization interface [polypeptide binding]; other site
439851008646	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439851008647	putative binding surface; other site
439851008648	active site
439851008649	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
439851008650	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
439851008651	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
439851008652	active site
439851008653	tetramer interface [polypeptide binding]; other site
439851008654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008655	D-galactonate transporter; Region: 2A0114; TIGR00893
439851008656	putative substrate translocation pore; other site
439851008657	flavodoxin; Provisional; Region: PRK08105
439851008658	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
439851008659	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
439851008660	probable active site [active]
439851008661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
439851008662	SecY interacting protein Syd; Provisional; Region: PRK04968
439851008663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
439851008664	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
439851008665	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
439851008666	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
439851008667	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
439851008668	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439851008669	serine transporter; Region: stp; TIGR00814
439851008670	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
439851008671	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439851008672	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439851008673	flap endonuclease-like protein; Provisional; Region: PRK09482
439851008674	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
439851008675	active site
439851008676	metal binding site 1 [ion binding]; metal-binding site
439851008677	putative 5' ssDNA interaction site; other site
439851008678	metal binding site 3; metal-binding site
439851008679	metal binding site 2 [ion binding]; metal-binding site
439851008680	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
439851008681	putative DNA binding site [nucleotide binding]; other site
439851008682	putative metal binding site [ion binding]; other site
439851008683	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
439851008684	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
439851008685	dimer interface [polypeptide binding]; other site
439851008686	active site
439851008687	metal binding site [ion binding]; metal-binding site
439851008688	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439851008689	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
439851008690	intersubunit interface [polypeptide binding]; other site
439851008691	active site
439851008692	Zn2+ binding site [ion binding]; other site
439851008693	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
439851008694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008695	putative substrate translocation pore; other site
439851008696	L-fucose isomerase; Provisional; Region: fucI; PRK10991
439851008697	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
439851008698	hexamer (dimer of trimers) interface [polypeptide binding]; other site
439851008699	trimer interface [polypeptide binding]; other site
439851008700	substrate binding site [chemical binding]; other site
439851008701	Mn binding site [ion binding]; other site
439851008702	L-fuculokinase; Provisional; Region: PRK10331
439851008703	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
439851008704	nucleotide binding site [chemical binding]; other site
439851008705	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
439851008706	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
439851008707	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439851008708	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851008709	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
439851008710	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
439851008711	hypothetical protein; Provisional; Region: PRK10873
439851008712	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
439851008713	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851008714	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
439851008715	dimerization interface [polypeptide binding]; other site
439851008716	substrate binding pocket [chemical binding]; other site
439851008717	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439851008718	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
439851008719	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
439851008720	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851008721	catalytic residue [active]
439851008722	CsdA-binding activator; Provisional; Region: PRK15019
439851008723	Predicted permeases [General function prediction only]; Region: RarD; COG2962
439851008724	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
439851008725	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
439851008726	putative ATP binding site [chemical binding]; other site
439851008727	putative substrate interface [chemical binding]; other site
439851008728	N-acetylglutamate synthase; Validated; Region: PRK05279
439851008729	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
439851008730	putative feedback inhibition sensing region; other site
439851008731	putative nucleotide binding site [chemical binding]; other site
439851008732	putative substrate binding site [chemical binding]; other site
439851008733	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851008734	Coenzyme A binding pocket [chemical binding]; other site
439851008735	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
439851008736	AAA domain; Region: AAA_30; pfam13604
439851008737	Family description; Region: UvrD_C_2; pfam13538
439851008738	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
439851008739	protease3; Provisional; Region: PRK15101
439851008740	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
439851008741	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
439851008742	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
439851008743	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
439851008744	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
439851008745	hypothetical protein; Provisional; Region: PRK10332
439851008746	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
439851008747	hypothetical protein; Provisional; Region: PRK11521
439851008748	hypothetical protein; Provisional; Region: PRK10557
439851008749	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
439851008750	hypothetical protein; Provisional; Region: PRK10506
439851008751	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
439851008752	thymidylate synthase; Reviewed; Region: thyA; PRK01827
439851008753	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
439851008754	dimerization interface [polypeptide binding]; other site
439851008755	active site
439851008756	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
439851008757	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
439851008758	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
439851008759	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
439851008760	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
439851008761	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
439851008762	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
439851008763	putative active site [active]
439851008764	Ap4A binding site [chemical binding]; other site
439851008765	nudix motif; other site
439851008766	putative metal binding site [ion binding]; other site
439851008767	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
439851008768	putative DNA-binding cleft [nucleotide binding]; other site
439851008769	putative DNA clevage site; other site
439851008770	molecular lever; other site
439851008771	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
439851008772	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439851008773	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851008774	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851008775	active site
439851008776	catalytic tetrad [active]
439851008777	lysophospholipid transporter LplT; Provisional; Region: PRK11195
439851008778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008779	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
439851008780	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
439851008781	putative acyl-acceptor binding pocket; other site
439851008782	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
439851008783	acyl-activating enzyme (AAE) consensus motif; other site
439851008784	putative AMP binding site [chemical binding]; other site
439851008785	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
439851008786	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851008787	DNA binding site [nucleotide binding]
439851008788	domain linker motif; other site
439851008789	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439851008790	dimerization interface (closed form) [polypeptide binding]; other site
439851008791	ligand binding site [chemical binding]; other site
439851008792	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439851008793	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851008794	DNA binding site [nucleotide binding]
439851008795	domain linker motif; other site
439851008796	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439851008797	dimerization interface (closed form) [polypeptide binding]; other site
439851008798	ligand binding site [chemical binding]; other site
439851008799	diaminopimelate decarboxylase; Provisional; Region: PRK11165
439851008800	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
439851008801	active site
439851008802	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439851008803	substrate binding site [chemical binding]; other site
439851008804	catalytic residues [active]
439851008805	dimer interface [polypeptide binding]; other site
439851008806	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
439851008807	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851008808	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851008809	dimerization interface [polypeptide binding]; other site
439851008810	putative racemase; Provisional; Region: PRK10200
439851008811	aspartate racemase; Region: asp_race; TIGR00035
439851008812	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
439851008813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008814	putative substrate translocation pore; other site
439851008815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851008816	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
439851008817	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
439851008818	NADP binding site [chemical binding]; other site
439851008819	homodimer interface [polypeptide binding]; other site
439851008820	active site
439851008821	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
439851008822	putative acyltransferase; Provisional; Region: PRK05790
439851008823	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
439851008824	dimer interface [polypeptide binding]; other site
439851008825	active site
439851008826	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851008827	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851008828	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851008829	dimerization interface [polypeptide binding]; other site
439851008830	Predicted membrane protein [Function unknown]; Region: COG4125
439851008831	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
439851008832	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
439851008833	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439851008834	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
439851008835	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
439851008836	putative metal binding site [ion binding]; other site
439851008837	putative homodimer interface [polypeptide binding]; other site
439851008838	putative homotetramer interface [polypeptide binding]; other site
439851008839	putative homodimer-homodimer interface [polypeptide binding]; other site
439851008840	putative allosteric switch controlling residues; other site
439851008841	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
439851008842	transcriptional activator SprB; Provisional; Region: PRK15320
439851008843	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600
439851008844	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
439851008845	Fimbrial protein; Region: Fimbrial; pfam00419
439851008846	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
439851008847	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851008848	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851008849	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
439851008850	PapC N-terminal domain; Region: PapC_N; pfam13954
439851008851	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851008852	PapC C-terminal domain; Region: PapC_C; pfam13953
439851008853	fimbrial protein StdA; Provisional; Region: PRK15210
439851008854	hypothetical protein; Provisional; Region: PRK10316
439851008855	YfdX protein; Region: YfdX; pfam10938
439851008856	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
439851008857	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
439851008858	oligomeric interface; other site
439851008859	putative active site [active]
439851008860	homodimer interface [polypeptide binding]; other site
439851008861	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
439851008862	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
439851008863	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439851008864	Peptidase family M23; Region: Peptidase_M23; pfam01551
439851008865	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
439851008866	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
439851008867	active site
439851008868	metal binding site [ion binding]; metal-binding site
439851008869	nudix motif; other site
439851008870	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
439851008871	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
439851008872	dimer interface [polypeptide binding]; other site
439851008873	putative anticodon binding site; other site
439851008874	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
439851008875	motif 1; other site
439851008876	active site
439851008877	motif 2; other site
439851008878	motif 3; other site
439851008879	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
439851008880	DHH family; Region: DHH; pfam01368
439851008881	DHHA1 domain; Region: DHHA1; pfam02272
439851008882	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
439851008883	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
439851008884	dimerization domain [polypeptide binding]; other site
439851008885	dimer interface [polypeptide binding]; other site
439851008886	catalytic residues [active]
439851008887	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
439851008888	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
439851008889	active site
439851008890	Int/Topo IB signature motif; other site
439851008891	flavodoxin FldB; Provisional; Region: PRK12359
439851008892	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
439851008893	hypothetical protein; Provisional; Region: PRK10878
439851008894	putative global regulator; Reviewed; Region: PRK09559
439851008895	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
439851008896	hemolysin; Provisional; Region: PRK15087
439851008897	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
439851008898	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
439851008899	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
439851008900	beta-galactosidase; Region: BGL; TIGR03356
439851008901	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
439851008902	glycine dehydrogenase; Provisional; Region: PRK05367
439851008903	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
439851008904	tetramer interface [polypeptide binding]; other site
439851008905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851008906	catalytic residue [active]
439851008907	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
439851008908	tetramer interface [polypeptide binding]; other site
439851008909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851008910	catalytic residue [active]
439851008911	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
439851008912	lipoyl attachment site [posttranslational modification]; other site
439851008913	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
439851008914	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
439851008915	oxidoreductase; Provisional; Region: PRK08013
439851008916	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
439851008917	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
439851008918	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
439851008919	proline aminopeptidase P II; Provisional; Region: PRK10879
439851008920	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
439851008921	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
439851008922	active site
439851008923	hypothetical protein; Reviewed; Region: PRK01736
439851008924	Cell division protein ZapA; Region: ZapA; cl01146
439851008925	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
439851008926	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
439851008927	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
439851008928	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
439851008929	ligand binding site [chemical binding]; other site
439851008930	NAD binding site [chemical binding]; other site
439851008931	tetramer interface [polypeptide binding]; other site
439851008932	catalytic site [active]
439851008933	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
439851008934	L-serine binding site [chemical binding]; other site
439851008935	ACT domain interface; other site
439851008936	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
439851008937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851008938	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
439851008939	putative dimerization interface [polypeptide binding]; other site
439851008940	Uncharacterized conserved protein [Function unknown]; Region: COG2968
439851008941	oxidative stress defense protein; Provisional; Region: PRK11087
439851008942	mechanosensitive channel MscS; Provisional; Region: PRK10334
439851008943	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851008944	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
439851008945	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
439851008946	active site
439851008947	intersubunit interface [polypeptide binding]; other site
439851008948	zinc binding site [ion binding]; other site
439851008949	Na+ binding site [ion binding]; other site
439851008950	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
439851008951	Phosphoglycerate kinase; Region: PGK; pfam00162
439851008952	substrate binding site [chemical binding]; other site
439851008953	hinge regions; other site
439851008954	ADP binding site [chemical binding]; other site
439851008955	catalytic site [active]
439851008956	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
439851008957	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
439851008958	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
439851008959	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
439851008960	trimer interface [polypeptide binding]; other site
439851008961	putative Zn binding site [ion binding]; other site
439851008962	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
439851008963	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
439851008964	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
439851008965	Walker A/P-loop; other site
439851008966	ATP binding site [chemical binding]; other site
439851008967	Q-loop/lid; other site
439851008968	ABC transporter signature motif; other site
439851008969	Walker B; other site
439851008970	D-loop; other site
439851008971	H-loop/switch region; other site
439851008972	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
439851008973	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
439851008974	Walker A/P-loop; other site
439851008975	ATP binding site [chemical binding]; other site
439851008976	Q-loop/lid; other site
439851008977	ABC transporter signature motif; other site
439851008978	Walker B; other site
439851008979	D-loop; other site
439851008980	H-loop/switch region; other site
439851008981	transketolase; Reviewed; Region: PRK12753
439851008982	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
439851008983	TPP-binding site [chemical binding]; other site
439851008984	dimer interface [polypeptide binding]; other site
439851008985	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439851008986	PYR/PP interface [polypeptide binding]; other site
439851008987	dimer interface [polypeptide binding]; other site
439851008988	TPP binding site [chemical binding]; other site
439851008989	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439851008990	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
439851008991	agmatinase; Region: agmatinase; TIGR01230
439851008992	oligomer interface [polypeptide binding]; other site
439851008993	putative active site [active]
439851008994	Mn binding site [ion binding]; other site
439851008995	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
439851008996	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
439851008997	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439851008998	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
439851008999	putative NAD(P) binding site [chemical binding]; other site
439851009000	catalytic Zn binding site [ion binding]; other site
439851009001	structural Zn binding site [ion binding]; other site
439851009002	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
439851009003	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
439851009004	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
439851009005	Transcriptional regulators [Transcription]; Region: FadR; COG2186
439851009006	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851009007	DNA-binding site [nucleotide binding]; DNA binding site
439851009008	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439851009009	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
439851009010	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
439851009011	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
439851009012	dimer interface [polypeptide binding]; other site
439851009013	active site
439851009014	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439851009015	catalytic residues [active]
439851009016	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
439851009017	Virulence promoting factor; Region: YqgB; pfam11036
439851009018	S-adenosylmethionine synthetase; Validated; Region: PRK05250
439851009019	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
439851009020	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
439851009021	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
439851009022	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
439851009023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851009024	putative substrate translocation pore; other site
439851009025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851009026	hypothetical protein; Provisional; Region: PRK04860
439851009027	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
439851009028	DNA-specific endonuclease I; Provisional; Region: PRK15137
439851009029	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
439851009030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
439851009031	RNA methyltransferase, RsmE family; Region: TIGR00046
439851009032	glutathione synthetase; Provisional; Region: PRK05246
439851009033	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
439851009034	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
439851009035	hypothetical protein; Validated; Region: PRK00228
439851009036	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
439851009037	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
439851009038	Transcriptional regulator [Transcription]; Region: IclR; COG1414
439851009039	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
439851009040	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
439851009041	Walker A motif; other site
439851009042	ATP binding site [chemical binding]; other site
439851009043	Walker B motif; other site
439851009044	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
439851009045	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439851009046	catalytic residue [active]
439851009047	YGGT family; Region: YGGT; pfam02325
439851009048	YGGT family; Region: YGGT; pfam02325
439851009049	hypothetical protein; Validated; Region: PRK05090
439851009050	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
439851009051	active site
439851009052	dimerization interface [polypeptide binding]; other site
439851009053	HemN family oxidoreductase; Provisional; Region: PRK05660
439851009054	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851009055	FeS/SAM binding site; other site
439851009056	HemN C-terminal domain; Region: HemN_C; pfam06969
439851009057	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
439851009058	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
439851009059	homodimer interface [polypeptide binding]; other site
439851009060	active site
439851009061	hypothetical protein; Provisional; Region: PRK10626
439851009062	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
439851009063	hypothetical protein; Provisional; Region: PRK11702
439851009064	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
439851009065	adenine DNA glycosylase; Provisional; Region: PRK10880
439851009066	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
439851009067	minor groove reading motif; other site
439851009068	helix-hairpin-helix signature motif; other site
439851009069	substrate binding pocket [chemical binding]; other site
439851009070	active site
439851009071	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
439851009072	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
439851009073	DNA binding and oxoG recognition site [nucleotide binding]
439851009074	oxidative damage protection protein; Provisional; Region: PRK05408
439851009075	murein transglycosylase C; Provisional; Region: mltC; PRK11671
439851009076	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
439851009077	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439851009078	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851009079	catalytic residue [active]
439851009080	nucleoside transporter; Region: 2A0110; TIGR00889
439851009081	ornithine decarboxylase; Provisional; Region: PRK13578
439851009082	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439851009083	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439851009084	homodimer interface [polypeptide binding]; other site
439851009085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851009086	catalytic residue [active]
439851009087	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439851009088	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
439851009089	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
439851009090	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
439851009091	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
439851009092	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
439851009093	putative active site [active]
439851009094	putative catalytic site [active]
439851009095	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
439851009096	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
439851009097	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851009098	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
439851009099	putative dimerization interface [polypeptide binding]; other site
439851009100	putative substrate binding pocket [chemical binding]; other site
439851009101	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
439851009102	Sulfatase; Region: Sulfatase; pfam00884
439851009103	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439851009104	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851009105	FeS/SAM binding site; other site
439851009106	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439851009107	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
439851009108	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851009109	DNA binding residues [nucleotide binding]
439851009110	dimerization interface [polypeptide binding]; other site
439851009111	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
439851009112	Amino acid permease; Region: AA_permease_2; pfam13520
439851009113	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
439851009114	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
439851009115	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
439851009116	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
439851009117	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
439851009118	NAD(P) binding site [chemical binding]; other site
439851009119	catalytic residues [active]
439851009120	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
439851009121	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
439851009122	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
439851009123	active site
439851009124	catalytic site [active]
439851009125	Zn binding site [ion binding]; other site
439851009126	tetramer interface [polypeptide binding]; other site
439851009127	Predicted amidohydrolase [General function prediction only]; Region: COG0388
439851009128	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
439851009129	putative active site [active]
439851009130	catalytic triad [active]
439851009131	putative dimer interface [polypeptide binding]; other site
439851009132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851009133	D-galactonate transporter; Region: 2A0114; TIGR00893
439851009134	putative substrate translocation pore; other site
439851009135	mannonate dehydratase; Provisional; Region: PRK03906
439851009136	mannonate dehydratase; Region: uxuA; TIGR00695
439851009137	D-mannonate oxidoreductase; Provisional; Region: PRK15037
439851009138	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
439851009139	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
439851009140	Glucuronate isomerase; Region: UxaC; pfam02614
439851009141	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
439851009142	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851009143	dimer interface [polypeptide binding]; other site
439851009144	putative CheW interface [polypeptide binding]; other site
439851009145	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
439851009146	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
439851009147	CHAP domain; Region: CHAP; pfam05257
439851009148	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
439851009149	putative S-transferase; Provisional; Region: PRK11752
439851009150	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
439851009151	C-terminal domain interface [polypeptide binding]; other site
439851009152	GSH binding site (G-site) [chemical binding]; other site
439851009153	dimer interface [polypeptide binding]; other site
439851009154	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
439851009155	dimer interface [polypeptide binding]; other site
439851009156	N-terminal domain interface [polypeptide binding]; other site
439851009157	active site
439851009158	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
439851009159	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
439851009160	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
439851009161	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
439851009162	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
439851009163	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
439851009164	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
439851009165	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
439851009166	putative substrate-binding site; other site
439851009167	nickel binding site [ion binding]; other site
439851009168	hydrogenase 2 large subunit; Provisional; Region: PRK10467
439851009169	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
439851009170	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
439851009171	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
439851009172	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
439851009173	4Fe-4S binding domain; Region: Fer4_6; pfam12837
439851009174	hydrogenase 2 small subunit; Provisional; Region: PRK10468
439851009175	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
439851009176	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
439851009177	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
439851009178	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
439851009179	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851009180	dimerization interface [polypeptide binding]; other site
439851009181	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851009182	dimer interface [polypeptide binding]; other site
439851009183	putative CheW interface [polypeptide binding]; other site
439851009184	hypothetical protein; Provisional; Region: PRK05208
439851009185	oxidoreductase; Provisional; Region: PRK07985
439851009186	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
439851009187	NAD binding site [chemical binding]; other site
439851009188	metal binding site [ion binding]; metal-binding site
439851009189	active site
439851009190	biopolymer transport protein ExbD; Provisional; Region: PRK11267
439851009191	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
439851009192	biopolymer transport protein ExbB; Provisional; Region: PRK10414
439851009193	cystathionine beta-lyase; Provisional; Region: PRK08114
439851009194	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
439851009195	homodimer interface [polypeptide binding]; other site
439851009196	substrate-cofactor binding pocket; other site
439851009197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851009198	catalytic residue [active]
439851009199	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439851009200	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
439851009201	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
439851009202	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
439851009203	dimer interface [polypeptide binding]; other site
439851009204	active site
439851009205	metal binding site [ion binding]; metal-binding site
439851009206	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439851009207	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439851009208	active site
439851009209	catalytic tetrad [active]
439851009210	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
439851009211	nucleotide binding site/active site [active]
439851009212	catalytic residue [active]
439851009213	hypothetical protein; Provisional; Region: PRK01254
439851009214	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
439851009215	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
439851009216	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
439851009217	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
439851009218	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
439851009219	DctM-like transporters; Region: DctM; pfam06808
439851009220	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
439851009221	FtsI repressor; Provisional; Region: PRK10883
439851009222	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
439851009223	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
439851009224	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
439851009225	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
439851009226	putative acyl-acceptor binding pocket; other site
439851009227	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
439851009228	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
439851009229	CAP-like domain; other site
439851009230	active site
439851009231	primary dimer interface [polypeptide binding]; other site
439851009232	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851009233	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851009234	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
439851009235	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
439851009236	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
439851009237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851009238	active site
439851009239	phosphorylation site [posttranslational modification]
439851009240	intermolecular recognition site; other site
439851009241	dimerization interface [polypeptide binding]; other site
439851009242	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851009243	DNA binding site [nucleotide binding]
439851009244	sensor protein QseC; Provisional; Region: PRK10337
439851009245	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
439851009246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851009247	dimer interface [polypeptide binding]; other site
439851009248	phosphorylation site [posttranslational modification]
439851009249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851009250	ATP binding site [chemical binding]; other site
439851009251	Mg2+ binding site [ion binding]; other site
439851009252	G-X-G motif; other site
439851009253	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
439851009254	Uncharacterized conserved protein [Function unknown]; Region: COG1359
439851009255	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
439851009256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851009257	ATP binding site [chemical binding]; other site
439851009258	Mg2+ binding site [ion binding]; other site
439851009259	G-X-G motif; other site
439851009260	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
439851009261	anchoring element; other site
439851009262	dimer interface [polypeptide binding]; other site
439851009263	ATP binding site [chemical binding]; other site
439851009264	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
439851009265	active site
439851009266	metal binding site [ion binding]; metal-binding site
439851009267	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
439851009268	esterase YqiA; Provisional; Region: PRK11071
439851009269	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
439851009270	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439851009271	active site
439851009272	metal binding site [ion binding]; metal-binding site
439851009273	hexamer interface [polypeptide binding]; other site
439851009274	putative dehydrogenase; Provisional; Region: PRK11039
439851009275	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
439851009276	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
439851009277	dimer interface [polypeptide binding]; other site
439851009278	ADP-ribose binding site [chemical binding]; other site
439851009279	active site
439851009280	nudix motif; other site
439851009281	metal binding site [ion binding]; metal-binding site
439851009282	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
439851009283	hypothetical protein; Provisional; Region: PRK11653
439851009284	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
439851009285	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
439851009286	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
439851009287	putative active site [active]
439851009288	metal binding site [ion binding]; metal-binding site
439851009289	zinc transporter ZupT; Provisional; Region: PRK04201
439851009290	ZIP Zinc transporter; Region: Zip; pfam02535
439851009291	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
439851009292	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439851009293	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
439851009294	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439851009295	catalytic residues [active]
439851009296	hinge region; other site
439851009297	alpha helical domain; other site
439851009298	putative disulfide oxidoreductase; Provisional; Region: PRK04307
439851009299	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
439851009300	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
439851009301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
439851009302	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
439851009303	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
439851009304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
439851009305	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
439851009306	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
439851009307	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
439851009308	putative ribose interaction site [chemical binding]; other site
439851009309	putative ADP binding site [chemical binding]; other site
439851009310	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
439851009311	active site
439851009312	nucleotide binding site [chemical binding]; other site
439851009313	HIGH motif; other site
439851009314	KMSKS motif; other site
439851009315	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
439851009316	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
439851009317	metal binding triad; other site
439851009318	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
439851009319	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
439851009320	metal binding triad; other site
439851009321	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
439851009322	Uncharacterized conserved protein [Function unknown]; Region: COG3025
439851009323	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
439851009324	putative active site [active]
439851009325	putative metal binding residues [ion binding]; other site
439851009326	signature motif; other site
439851009327	putative triphosphate binding site [ion binding]; other site
439851009328	CHAD domain; Region: CHAD; pfam05235
439851009329	SH3 domain-containing protein; Provisional; Region: PRK10884
439851009330	Bacterial SH3 domain homologues; Region: SH3b; smart00287
439851009331	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
439851009332	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
439851009333	active site
439851009334	NTP binding site [chemical binding]; other site
439851009335	metal binding triad [ion binding]; metal-binding site
439851009336	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
439851009337	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439851009338	Zn2+ binding site [ion binding]; other site
439851009339	Mg2+ binding site [ion binding]; other site
439851009340	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
439851009341	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
439851009342	homooctamer interface [polypeptide binding]; other site
439851009343	active site
439851009344	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
439851009345	UGMP family protein; Validated; Region: PRK09604
439851009346	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
439851009347	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
439851009348	DNA primase; Validated; Region: dnaG; PRK05667
439851009349	CHC2 zinc finger; Region: zf-CHC2; pfam01807
439851009350	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
439851009351	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
439851009352	active site
439851009353	metal binding site [ion binding]; metal-binding site
439851009354	interdomain interaction site; other site
439851009355	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
439851009356	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
439851009357	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
439851009358	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
439851009359	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
439851009360	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
439851009361	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439851009362	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
439851009363	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439851009364	DNA binding residues [nucleotide binding]
439851009365	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
439851009366	active site
439851009367	SUMO-1 interface [polypeptide binding]; other site
439851009368	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
439851009369	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
439851009370	FAD binding pocket [chemical binding]; other site
439851009371	FAD binding motif [chemical binding]; other site
439851009372	phosphate binding motif [ion binding]; other site
439851009373	NAD binding pocket [chemical binding]; other site
439851009374	Predicted transcriptional regulators [Transcription]; Region: COG1695
439851009375	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
439851009376	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
439851009377	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851009378	dimerization interface [polypeptide binding]; other site
439851009379	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
439851009380	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851009381	dimer interface [polypeptide binding]; other site
439851009382	putative CheW interface [polypeptide binding]; other site
439851009383	PAS fold; Region: PAS_3; pfam08447
439851009384	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439851009385	putative active site [active]
439851009386	heme pocket [chemical binding]; other site
439851009387	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
439851009388	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
439851009389	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851009390	dimer interface [polypeptide binding]; other site
439851009391	putative CheW interface [polypeptide binding]; other site
439851009392	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
439851009393	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439851009394	inhibitor-cofactor binding pocket; inhibition site
439851009395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851009396	catalytic residue [active]
439851009397	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
439851009398	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
439851009399	active site
439851009400	FMN binding site [chemical binding]; other site
439851009401	2,4-decadienoyl-CoA binding site; other site
439851009402	catalytic residue [active]
439851009403	4Fe-4S cluster binding site [ion binding]; other site
439851009404	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
439851009405	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851009406	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
439851009407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851009408	S-adenosylmethionine binding site [chemical binding]; other site
439851009409	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
439851009410	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439851009411	putative active site [active]
439851009412	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
439851009413	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439851009414	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
439851009415	serine/threonine transporter SstT; Provisional; Region: PRK13628
439851009416	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439851009417	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439851009418	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
439851009419	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
439851009420	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
439851009421	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
439851009422	Predicted membrane protein [Function unknown]; Region: COG5393
439851009423	YqjK-like protein; Region: YqjK; pfam13997
439851009424	Predicted membrane protein [Function unknown]; Region: COG2259
439851009425	Predicted membrane protein [Function unknown]; Region: COG3152
439851009426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851009427	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
439851009428	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439851009429	dimerization interface [polypeptide binding]; other site
439851009430	Pirin-related protein [General function prediction only]; Region: COG1741
439851009431	Pirin; Region: Pirin; pfam02678
439851009432	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
439851009433	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439851009434	serine transporter; Region: stp; TIGR00814
439851009435	L-serine dehydratase TdcG; Provisional; Region: PRK15040
439851009436	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439851009437	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439851009438	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
439851009439	Pyruvate formate lyase 1; Region: PFL1; cd01678
439851009440	coenzyme A binding site [chemical binding]; other site
439851009441	active site
439851009442	catalytic residues [active]
439851009443	glycine loop; other site
439851009444	propionate/acetate kinase; Provisional; Region: PRK12379
439851009445	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
439851009446	threonine/serine transporter TdcC; Provisional; Region: PRK13629
439851009447	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439851009448	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
439851009449	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
439851009450	tetramer interface [polypeptide binding]; other site
439851009451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851009452	catalytic residue [active]
439851009453	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
439851009454	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851009455	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
439851009456	putative substrate binding pocket [chemical binding]; other site
439851009457	putative dimerization interface [polypeptide binding]; other site
439851009458	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
439851009459	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439851009460	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
439851009461	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
439851009462	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
439851009463	intersubunit interface [polypeptide binding]; other site
439851009464	active site
439851009465	zinc binding site [ion binding]; other site
439851009466	Na+ binding site [ion binding]; other site
439851009467	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
439851009468	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851009469	active site
439851009470	phosphorylation site [posttranslational modification]
439851009471	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
439851009472	active site
439851009473	P-loop; other site
439851009474	phosphorylation site [posttranslational modification]
439851009475	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
439851009476	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
439851009477	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
439851009478	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
439851009479	putative NAD(P) binding site [chemical binding]; other site
439851009480	catalytic Zn binding site [ion binding]; other site
439851009481	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851009482	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851009483	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851009484	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
439851009485	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
439851009486	putative SAM binding site [chemical binding]; other site
439851009487	putative homodimer interface [polypeptide binding]; other site
439851009488	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
439851009489	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
439851009490	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
439851009491	putative ligand binding site [chemical binding]; other site
439851009492	TIGR00252 family protein; Region: TIGR00252
439851009493	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
439851009494	dimer interface [polypeptide binding]; other site
439851009495	active site
439851009496	outer membrane lipoprotein; Provisional; Region: PRK11023
439851009497	BON domain; Region: BON; pfam04972
439851009498	BON domain; Region: BON; pfam04972
439851009499	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
439851009500	NADH(P)-binding; Region: NAD_binding_10; pfam13460
439851009501	NAD binding site [chemical binding]; other site
439851009502	active site
439851009503	intracellular protease, PfpI family; Region: PfpI; TIGR01382
439851009504	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
439851009505	proposed catalytic triad [active]
439851009506	conserved cys residue [active]
439851009507	hypothetical protein; Provisional; Region: PRK03467
439851009508	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
439851009509	GIY-YIG motif/motif A; other site
439851009510	putative active site [active]
439851009511	putative metal binding site [ion binding]; other site
439851009512	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
439851009513	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851009514	Coenzyme A binding pocket [chemical binding]; other site
439851009515	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
439851009516	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
439851009517	Peptidase family U32; Region: Peptidase_U32; pfam01136
439851009518	putative protease; Provisional; Region: PRK15447
439851009519	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
439851009520	hypothetical protein; Provisional; Region: PRK10508
439851009521	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
439851009522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
439851009523	tryptophan permease; Provisional; Region: PRK10483
439851009524	aromatic amino acid transport protein; Region: araaP; TIGR00837
439851009525	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439851009526	DEAD-like helicases superfamily; Region: DEXDc; smart00487
439851009527	ATP binding site [chemical binding]; other site
439851009528	Mg++ binding site [ion binding]; other site
439851009529	motif III; other site
439851009530	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851009531	nucleotide binding region [chemical binding]; other site
439851009532	ATP-binding site [chemical binding]; other site
439851009533	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
439851009534	putative RNA binding site [nucleotide binding]; other site
439851009535	lipoprotein NlpI; Provisional; Region: PRK11189
439851009536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439851009537	binding surface
439851009538	TPR motif; other site
439851009539	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
439851009540	16S/18S rRNA binding site [nucleotide binding]; other site
439851009541	S13e-L30e interaction site [polypeptide binding]; other site
439851009542	25S rRNA binding site [nucleotide binding]; other site
439851009543	Ribosomal S15 leader
439851009544	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
439851009545	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
439851009546	RNA binding site [nucleotide binding]; other site
439851009547	active site
439851009548	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
439851009549	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
439851009550	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
439851009551	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
439851009552	translation initiation factor IF-2; Region: IF-2; TIGR00487
439851009553	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
439851009554	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
439851009555	G1 box; other site
439851009556	putative GEF interaction site [polypeptide binding]; other site
439851009557	GTP/Mg2+ binding site [chemical binding]; other site
439851009558	Switch I region; other site
439851009559	G2 box; other site
439851009560	G3 box; other site
439851009561	Switch II region; other site
439851009562	G4 box; other site
439851009563	G5 box; other site
439851009564	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
439851009565	Translation-initiation factor 2; Region: IF-2; pfam11987
439851009566	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
439851009567	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
439851009568	NusA N-terminal domain; Region: NusA_N; pfam08529
439851009569	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
439851009570	RNA binding site [nucleotide binding]; other site
439851009571	homodimer interface [polypeptide binding]; other site
439851009572	NusA-like KH domain; Region: KH_5; pfam13184
439851009573	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
439851009574	G-X-X-G motif; other site
439851009575	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
439851009576	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
439851009577	ribosome maturation protein RimP; Reviewed; Region: PRK00092
439851009578	Sm and related proteins; Region: Sm_like; cl00259
439851009579	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
439851009580	putative oligomer interface [polypeptide binding]; other site
439851009581	putative RNA binding site [nucleotide binding]; other site
439851009582	argininosuccinate synthase; Validated; Region: PRK05370
439851009583	argininosuccinate synthase; Provisional; Region: PRK13820
439851009584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851009585	non-specific DNA binding site [nucleotide binding]; other site
439851009586	salt bridge; other site
439851009587	sequence-specific DNA binding site [nucleotide binding]; other site
439851009588	Preprotein translocase SecG subunit; Region: SecG; pfam03840
439851009589	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
439851009590	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
439851009591	active site
439851009592	substrate binding site [chemical binding]; other site
439851009593	metal binding site [ion binding]; metal-binding site
439851009594	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
439851009595	dihydropteroate synthase; Region: DHPS; TIGR01496
439851009596	substrate binding pocket [chemical binding]; other site
439851009597	dimer interface [polypeptide binding]; other site
439851009598	inhibitor binding site; inhibition site
439851009599	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
439851009600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851009601	Walker A motif; other site
439851009602	ATP binding site [chemical binding]; other site
439851009603	Walker B motif; other site
439851009604	arginine finger; other site
439851009605	Peptidase family M41; Region: Peptidase_M41; pfam01434
439851009606	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
439851009607	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851009608	S-adenosylmethionine binding site [chemical binding]; other site
439851009609	RNA-binding protein YhbY; Provisional; Region: PRK10343
439851009610	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
439851009611	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
439851009612	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
439851009613	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
439851009614	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
439851009615	GTPase CgtA; Reviewed; Region: obgE; PRK12298
439851009616	GTP1/OBG; Region: GTP1_OBG; pfam01018
439851009617	Obg GTPase; Region: Obg; cd01898
439851009618	G1 box; other site
439851009619	GTP/Mg2+ binding site [chemical binding]; other site
439851009620	Switch I region; other site
439851009621	G2 box; other site
439851009622	G3 box; other site
439851009623	Switch II region; other site
439851009624	G4 box; other site
439851009625	G5 box; other site
439851009626	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
439851009627	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
439851009628	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
439851009629	substrate binding pocket [chemical binding]; other site
439851009630	chain length determination region; other site
439851009631	substrate-Mg2+ binding site; other site
439851009632	catalytic residues [active]
439851009633	aspartate-rich region 1; other site
439851009634	active site lid residues [active]
439851009635	aspartate-rich region 2; other site
439851009636	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
439851009637	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
439851009638	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
439851009639	hinge; other site
439851009640	active site
439851009641	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
439851009642	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
439851009643	anti sigma factor interaction site; other site
439851009644	regulatory phosphorylation site [posttranslational modification]; other site
439851009645	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
439851009646	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
439851009647	mce related protein; Region: MCE; pfam02470
439851009648	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
439851009649	conserved hypothetical integral membrane protein; Region: TIGR00056
439851009650	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
439851009651	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
439851009652	Walker A/P-loop; other site
439851009653	ATP binding site [chemical binding]; other site
439851009654	Q-loop/lid; other site
439851009655	ABC transporter signature motif; other site
439851009656	Walker B; other site
439851009657	D-loop; other site
439851009658	H-loop/switch region; other site
439851009659	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
439851009660	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
439851009661	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
439851009662	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
439851009663	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
439851009664	putative active site [active]
439851009665	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
439851009666	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
439851009667	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
439851009668	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
439851009669	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
439851009670	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
439851009671	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
439851009672	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
439851009673	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
439851009674	Walker A/P-loop; other site
439851009675	ATP binding site [chemical binding]; other site
439851009676	Q-loop/lid; other site
439851009677	ABC transporter signature motif; other site
439851009678	Walker B; other site
439851009679	D-loop; other site
439851009680	H-loop/switch region; other site
439851009681	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
439851009682	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
439851009683	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
439851009684	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
439851009685	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
439851009686	30S subunit binding site; other site
439851009687	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851009688	active site
439851009689	phosphorylation site [posttranslational modification]
439851009690	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
439851009691	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439851009692	dimerization domain swap beta strand [polypeptide binding]; other site
439851009693	regulatory protein interface [polypeptide binding]; other site
439851009694	active site
439851009695	regulatory phosphorylation site [posttranslational modification]; other site
439851009696	hypothetical protein; Provisional; Region: PRK10345
439851009697	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
439851009698	Transglycosylase; Region: Transgly; cl17702
439851009699	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
439851009700	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
439851009701	conserved cys residue [active]
439851009702	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
439851009703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439851009704	putative active site [active]
439851009705	heme pocket [chemical binding]; other site
439851009706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851009707	dimer interface [polypeptide binding]; other site
439851009708	phosphorylation site [posttranslational modification]
439851009709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851009710	ATP binding site [chemical binding]; other site
439851009711	Mg2+ binding site [ion binding]; other site
439851009712	G-X-G motif; other site
439851009713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851009714	active site
439851009715	phosphorylation site [posttranslational modification]
439851009716	intermolecular recognition site; other site
439851009717	dimerization interface [polypeptide binding]; other site
439851009718	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439851009719	putative binding surface; other site
439851009720	active site
439851009721	radical SAM protein, TIGR01212 family; Region: TIGR01212
439851009722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851009723	FeS/SAM binding site; other site
439851009724	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
439851009725	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851009726	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851009727	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
439851009728	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
439851009729	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
439851009730	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
439851009731	Na binding site [ion binding]; other site
439851009732	putative substrate binding site [chemical binding]; other site
439851009733	cytosine deaminase; Provisional; Region: PRK09230
439851009734	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
439851009735	active site
439851009736	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
439851009737	N-acetylmannosamine kinase; Provisional; Region: PRK05082
439851009738	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851009739	nucleotide binding site [chemical binding]; other site
439851009740	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
439851009741	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
439851009742	putative active site cavity [active]
439851009743	putative sialic acid transporter; Provisional; Region: PRK03893
439851009744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851009745	putative substrate translocation pore; other site
439851009746	N-acetylneuraminate lyase; Provisional; Region: PRK04147
439851009747	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
439851009748	inhibitor site; inhibition site
439851009749	active site
439851009750	dimer interface [polypeptide binding]; other site
439851009751	catalytic residue [active]
439851009752	transcriptional regulator NanR; Provisional; Region: PRK03837
439851009753	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851009754	DNA-binding site [nucleotide binding]; DNA binding site
439851009755	FCD domain; Region: FCD; pfam07729
439851009756	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
439851009757	stringent starvation protein A; Provisional; Region: sspA; PRK09481
439851009758	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
439851009759	C-terminal domain interface [polypeptide binding]; other site
439851009760	putative GSH binding site (G-site) [chemical binding]; other site
439851009761	dimer interface [polypeptide binding]; other site
439851009762	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
439851009763	dimer interface [polypeptide binding]; other site
439851009764	N-terminal domain interface [polypeptide binding]; other site
439851009765	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
439851009766	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
439851009767	23S rRNA interface [nucleotide binding]; other site
439851009768	L3 interface [polypeptide binding]; other site
439851009769	Predicted ATPase [General function prediction only]; Region: COG1485
439851009770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
439851009771	hypothetical protein; Provisional; Region: PRK11677
439851009772	serine endoprotease; Provisional; Region: PRK10139
439851009773	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
439851009774	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439851009775	protein binding site [polypeptide binding]; other site
439851009776	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439851009777	serine endoprotease; Provisional; Region: PRK10898
439851009778	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
439851009779	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439851009780	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
439851009781	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
439851009782	oxaloacetate decarboxylase; Provisional; Region: PRK14040
439851009783	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
439851009784	active site
439851009785	catalytic residues [active]
439851009786	metal binding site [ion binding]; metal-binding site
439851009787	homodimer binding site [polypeptide binding]; other site
439851009788	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
439851009789	carboxyltransferase (CT) interaction site; other site
439851009790	biotinylation site [posttranslational modification]; other site
439851009791	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
439851009792	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
439851009793	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
439851009794	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
439851009795	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
439851009796	transmembrane helices; other site
439851009797	Transcriptional regulators [Transcription]; Region: GntR; COG1802
439851009798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851009799	DNA-binding site [nucleotide binding]; DNA binding site
439851009800	FCD domain; Region: FCD; pfam07729
439851009801	Transcriptional regulators [Transcription]; Region: GntR; COG1802
439851009802	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851009803	DNA-binding site [nucleotide binding]; DNA binding site
439851009804	malate dehydrogenase; Provisional; Region: PRK05086
439851009805	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
439851009806	NAD binding site [chemical binding]; other site
439851009807	dimerization interface [polypeptide binding]; other site
439851009808	Substrate binding site [chemical binding]; other site
439851009809	arginine repressor; Provisional; Region: PRK05066
439851009810	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
439851009811	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
439851009812	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851009813	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851009814	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
439851009815	RNAase interaction site [polypeptide binding]; other site
439851009816	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
439851009817	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439851009818	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
439851009819	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851009820	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851009821	efflux system membrane protein; Provisional; Region: PRK11594
439851009822	transcriptional regulator; Provisional; Region: PRK10632
439851009823	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851009824	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
439851009825	putative effector binding pocket; other site
439851009826	dimerization interface [polypeptide binding]; other site
439851009827	protease TldD; Provisional; Region: tldD; PRK10735
439851009828	hypothetical protein; Provisional; Region: PRK10899
439851009829	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
439851009830	ribonuclease G; Provisional; Region: PRK11712
439851009831	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
439851009832	homodimer interface [polypeptide binding]; other site
439851009833	oligonucleotide binding site [chemical binding]; other site
439851009834	Maf-like protein; Region: Maf; pfam02545
439851009835	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
439851009836	active site
439851009837	dimer interface [polypeptide binding]; other site
439851009838	rod shape-determining protein MreD; Provisional; Region: PRK11060
439851009839	rod shape-determining protein MreC; Region: mreC; TIGR00219
439851009840	rod shape-determining protein MreC; Region: MreC; pfam04085
439851009841	rod shape-determining protein MreB; Provisional; Region: PRK13927
439851009842	MreB and similar proteins; Region: MreB_like; cd10225
439851009843	nucleotide binding site [chemical binding]; other site
439851009844	Mg binding site [ion binding]; other site
439851009845	putative protofilament interaction site [polypeptide binding]; other site
439851009846	RodZ interaction site [polypeptide binding]; other site
439851009847	regulatory protein CsrD; Provisional; Region: PRK11059
439851009848	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851009849	metal binding site [ion binding]; metal-binding site
439851009850	active site
439851009851	I-site; other site
439851009852	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851009853	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
439851009854	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
439851009855	NADP binding site [chemical binding]; other site
439851009856	dimer interface [polypeptide binding]; other site
439851009857	TMAO/DMSO reductase; Reviewed; Region: PRK05363
439851009858	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
439851009859	Moco binding site; other site
439851009860	metal coordination site [ion binding]; other site
439851009861	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
439851009862	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
439851009863	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
439851009864	carboxyltransferase (CT) interaction site; other site
439851009865	biotinylation site [posttranslational modification]; other site
439851009866	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
439851009867	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
439851009868	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
439851009869	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
439851009870	hypothetical protein; Provisional; Region: PRK10633
439851009871	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
439851009872	Na binding site [ion binding]; other site
439851009873	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
439851009874	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
439851009875	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
439851009876	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
439851009877	FMN binding site [chemical binding]; other site
439851009878	active site
439851009879	catalytic residues [active]
439851009880	substrate binding site [chemical binding]; other site
439851009881	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
439851009882	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
439851009883	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
439851009884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851009885	DNA methylase; Region: N6_N4_Mtase; pfam01555
439851009886	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
439851009887	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
439851009888	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
439851009889	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
439851009890	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851009891	metal binding site [ion binding]; metal-binding site
439851009892	active site
439851009893	I-site; other site
439851009894	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851009895	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
439851009896	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851009897	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
439851009898	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
439851009899	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
439851009900	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
439851009901	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
439851009902	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
439851009903	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
439851009904	shikimate binding site; other site
439851009905	NAD(P) binding site [chemical binding]; other site
439851009906	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
439851009907	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439851009908	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
439851009909	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439851009910	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439851009911	hypothetical protein; Validated; Region: PRK03430
439851009912	hypothetical protein; Provisional; Region: PRK10736
439851009913	DNA protecting protein DprA; Region: dprA; TIGR00732
439851009914	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
439851009915	active site
439851009916	catalytic residues [active]
439851009917	metal binding site [ion binding]; metal-binding site
439851009918	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
439851009919	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
439851009920	putative active site [active]
439851009921	substrate binding site [chemical binding]; other site
439851009922	putative cosubstrate binding site; other site
439851009923	catalytic site [active]
439851009924	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
439851009925	substrate binding site [chemical binding]; other site
439851009926	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
439851009927	putative RNA binding site [nucleotide binding]; other site
439851009928	16S rRNA methyltransferase B; Provisional; Region: PRK10901
439851009929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851009930	S-adenosylmethionine binding site [chemical binding]; other site
439851009931	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
439851009932	TrkA-N domain; Region: TrkA_N; pfam02254
439851009933	TrkA-C domain; Region: TrkA_C; pfam02080
439851009934	TrkA-N domain; Region: TrkA_N; pfam02254
439851009935	TrkA-C domain; Region: TrkA_C; pfam02080
439851009936	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
439851009937	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
439851009938	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
439851009939	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
439851009940	DNA binding residues [nucleotide binding]
439851009941	dimer interface [polypeptide binding]; other site
439851009942	metal binding site [ion binding]; metal-binding site
439851009943	hypothetical protein; Provisional; Region: PRK10203
439851009944	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
439851009945	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
439851009946	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
439851009947	alphaNTD homodimer interface [polypeptide binding]; other site
439851009948	alphaNTD - beta interaction site [polypeptide binding]; other site
439851009949	alphaNTD - beta' interaction site [polypeptide binding]; other site
439851009950	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
439851009951	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
439851009952	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
439851009953	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851009954	RNA binding surface [nucleotide binding]; other site
439851009955	30S ribosomal protein S11; Validated; Region: PRK05309
439851009956	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
439851009957	30S ribosomal protein S13; Region: bact_S13; TIGR03631
439851009958	Alpha operon ribosome binding site
439851009959	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
439851009960	SecY translocase; Region: SecY; pfam00344
439851009961	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
439851009962	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
439851009963	23S rRNA binding site [nucleotide binding]; other site
439851009964	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
439851009965	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
439851009966	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
439851009967	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
439851009968	23S rRNA interface [nucleotide binding]; other site
439851009969	5S rRNA interface [nucleotide binding]; other site
439851009970	L27 interface [polypeptide binding]; other site
439851009971	L5 interface [polypeptide binding]; other site
439851009972	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
439851009973	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
439851009974	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
439851009975	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
439851009976	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
439851009977	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
439851009978	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
439851009979	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
439851009980	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
439851009981	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
439851009982	RNA binding site [nucleotide binding]; other site
439851009983	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
439851009984	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
439851009985	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
439851009986	23S rRNA interface [nucleotide binding]; other site
439851009987	putative translocon interaction site; other site
439851009988	signal recognition particle (SRP54) interaction site; other site
439851009989	L23 interface [polypeptide binding]; other site
439851009990	trigger factor interaction site; other site
439851009991	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
439851009992	23S rRNA interface [nucleotide binding]; other site
439851009993	5S rRNA interface [nucleotide binding]; other site
439851009994	putative antibiotic binding site [chemical binding]; other site
439851009995	L25 interface [polypeptide binding]; other site
439851009996	L27 interface [polypeptide binding]; other site
439851009997	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
439851009998	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
439851009999	G-X-X-G motif; other site
439851010000	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
439851010001	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
439851010002	protein-rRNA interface [nucleotide binding]; other site
439851010003	putative translocon binding site; other site
439851010004	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
439851010005	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
439851010006	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
439851010007	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
439851010008	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
439851010009	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
439851010010	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
439851010011	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
439851010012	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
439851010013	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
439851010014	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
439851010015	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
439851010016	heme binding site [chemical binding]; other site
439851010017	ferroxidase pore; other site
439851010018	ferroxidase diiron center [ion binding]; other site
439851010019	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
439851010020	elongation factor Tu; Reviewed; Region: PRK00049
439851010021	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
439851010022	G1 box; other site
439851010023	GEF interaction site [polypeptide binding]; other site
439851010024	GTP/Mg2+ binding site [chemical binding]; other site
439851010025	Switch I region; other site
439851010026	G2 box; other site
439851010027	G3 box; other site
439851010028	Switch II region; other site
439851010029	G4 box; other site
439851010030	G5 box; other site
439851010031	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
439851010032	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
439851010033	Antibiotic Binding Site [chemical binding]; other site
439851010034	elongation factor G; Reviewed; Region: PRK00007
439851010035	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
439851010036	G1 box; other site
439851010037	putative GEF interaction site [polypeptide binding]; other site
439851010038	GTP/Mg2+ binding site [chemical binding]; other site
439851010039	Switch I region; other site
439851010040	G2 box; other site
439851010041	G3 box; other site
439851010042	Switch II region; other site
439851010043	G4 box; other site
439851010044	G5 box; other site
439851010045	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
439851010046	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
439851010047	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
439851010048	30S ribosomal protein S7; Validated; Region: PRK05302
439851010049	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
439851010050	S17 interaction site [polypeptide binding]; other site
439851010051	S8 interaction site; other site
439851010052	16S rRNA interaction site [nucleotide binding]; other site
439851010053	streptomycin interaction site [chemical binding]; other site
439851010054	23S rRNA interaction site [nucleotide binding]; other site
439851010055	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
439851010056	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
439851010057	sulfur relay protein TusC; Validated; Region: PRK00211
439851010058	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
439851010059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
439851010060	YheO-like PAS domain; Region: PAS_6; pfam08348
439851010061	HTH domain; Region: HTH_22; pfam13309
439851010062	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
439851010063	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
439851010064	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439851010065	phi X174 lysis protein; Provisional; Region: PRK02793
439851010066	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
439851010067	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439851010068	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
439851010069	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
439851010070	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
439851010071	TrkA-N domain; Region: TrkA_N; pfam02254
439851010072	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
439851010073	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
439851010074	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851010075	Walker A/P-loop; other site
439851010076	ATP binding site [chemical binding]; other site
439851010077	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851010078	ABC transporter signature motif; other site
439851010079	Walker B; other site
439851010080	D-loop; other site
439851010081	ABC transporter; Region: ABC_tran_2; pfam12848
439851010082	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851010083	putative hydrolase; Provisional; Region: PRK10985
439851010084	hypothetical protein; Provisional; Region: PRK04966
439851010085	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
439851010086	active site
439851010087	hypothetical protein; Provisional; Region: PRK10738
439851010088	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
439851010089	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
439851010090	ligand binding site [chemical binding]; other site
439851010091	flexible hinge region; other site
439851010092	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
439851010093	putative switch regulator; other site
439851010094	non-specific DNA interactions [nucleotide binding]; other site
439851010095	DNA binding site [nucleotide binding]
439851010096	sequence specific DNA binding site [nucleotide binding]; other site
439851010097	putative cAMP binding site [chemical binding]; other site
439851010098	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
439851010099	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
439851010100	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439851010101	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
439851010102	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439851010103	inhibitor-cofactor binding pocket; inhibition site
439851010104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851010105	catalytic residue [active]
439851010106	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
439851010107	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
439851010108	glutamine binding [chemical binding]; other site
439851010109	catalytic triad [active]
439851010110	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
439851010111	cell filamentation protein Fic; Provisional; Region: PRK10347
439851010112	hypothetical protein; Provisional; Region: PRK10204
439851010113	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
439851010114	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
439851010115	substrate binding site [chemical binding]; other site
439851010116	putative transporter; Provisional; Region: PRK03699
439851010117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851010118	putative substrate translocation pore; other site
439851010119	nitrite reductase subunit NirD; Provisional; Region: PRK14989
439851010120	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851010121	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
439851010122	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
439851010123	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439851010124	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
439851010125	nitrite transporter NirC; Provisional; Region: PRK11562
439851010126	siroheme synthase; Provisional; Region: cysG; PRK10637
439851010127	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
439851010128	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
439851010129	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
439851010130	active site
439851010131	SAM binding site [chemical binding]; other site
439851010132	homodimer interface [polypeptide binding]; other site
439851010133	Autotransporter beta-domain; Region: Autotransporter; pfam03797
439851010134	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
439851010135	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
439851010136	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
439851010137	active site
439851010138	HIGH motif; other site
439851010139	dimer interface [polypeptide binding]; other site
439851010140	KMSKS motif; other site
439851010141	phosphoglycolate phosphatase; Provisional; Region: PRK13222
439851010142	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851010143	motif II; other site
439851010144	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
439851010145	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
439851010146	substrate binding site [chemical binding]; other site
439851010147	hexamer interface [polypeptide binding]; other site
439851010148	metal binding site [ion binding]; metal-binding site
439851010149	DNA adenine methylase; Provisional; Region: PRK10904
439851010150	cell division protein DamX; Validated; Region: PRK10905
439851010151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
439851010152	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
439851010153	active site
439851010154	dimer interface [polypeptide binding]; other site
439851010155	metal binding site [ion binding]; metal-binding site
439851010156	shikimate kinase; Reviewed; Region: aroK; PRK00131
439851010157	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
439851010158	ADP binding site [chemical binding]; other site
439851010159	magnesium binding site [ion binding]; other site
439851010160	putative shikimate binding site; other site
439851010161	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
439851010162	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
439851010163	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
439851010164	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
439851010165	Transglycosylase; Region: Transgly; pfam00912
439851010166	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
439851010167	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
439851010168	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
439851010169	ADP-ribose binding site [chemical binding]; other site
439851010170	dimer interface [polypeptide binding]; other site
439851010171	active site
439851010172	nudix motif; other site
439851010173	metal binding site [ion binding]; metal-binding site
439851010174	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
439851010175	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
439851010176	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851010177	motif II; other site
439851010178	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851010179	RNA binding surface [nucleotide binding]; other site
439851010180	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
439851010181	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
439851010182	dimerization interface [polypeptide binding]; other site
439851010183	domain crossover interface; other site
439851010184	redox-dependent activation switch; other site
439851010185	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
439851010186	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
439851010187	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
439851010188	active site
439851010189	substrate-binding site [chemical binding]; other site
439851010190	metal-binding site [ion binding]
439851010191	ATP binding site [chemical binding]; other site
439851010192	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
439851010193	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851010194	dimerization interface [polypeptide binding]; other site
439851010195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851010196	dimer interface [polypeptide binding]; other site
439851010197	phosphorylation site [posttranslational modification]
439851010198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851010199	ATP binding site [chemical binding]; other site
439851010200	G-X-G motif; other site
439851010201	osmolarity response regulator; Provisional; Region: ompR; PRK09468
439851010202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851010203	active site
439851010204	phosphorylation site [posttranslational modification]
439851010205	intermolecular recognition site; other site
439851010206	dimerization interface [polypeptide binding]; other site
439851010207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851010208	DNA binding site [nucleotide binding]
439851010209	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
439851010210	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
439851010211	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
439851010212	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
439851010213	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
439851010214	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
439851010215	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
439851010216	RNA binding site [nucleotide binding]; other site
439851010217	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
439851010218	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
439851010219	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
439851010220	G1 box; other site
439851010221	GTP/Mg2+ binding site [chemical binding]; other site
439851010222	Switch I region; other site
439851010223	G2 box; other site
439851010224	G3 box; other site
439851010225	Switch II region; other site
439851010226	G4 box; other site
439851010227	G5 box; other site
439851010228	Nucleoside recognition; Region: Gate; pfam07670
439851010229	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
439851010230	Nucleoside recognition; Region: Gate; pfam07670
439851010231	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
439851010232	hypothetical protein; Provisional; Region: PRK09956
439851010233	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
439851010234	carboxylesterase BioH; Provisional; Region: PRK10349
439851010235	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
439851010236	DNA utilization protein GntX; Provisional; Region: PRK11595
439851010237	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851010238	active site
439851010239	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
439851010240	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
439851010241	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
439851010242	high-affinity gluconate transporter; Provisional; Region: PRK14984
439851010243	gluconate transporter; Region: gntP; TIGR00791
439851010244	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
439851010245	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
439851010246	maltodextrin phosphorylase; Provisional; Region: PRK14985
439851010247	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
439851010248	homodimer interface [polypeptide binding]; other site
439851010249	active site pocket [active]
439851010250	transcriptional regulator MalT; Provisional; Region: PRK04841
439851010251	AAA ATPase domain; Region: AAA_16; pfam13191
439851010252	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851010253	DNA binding residues [nucleotide binding]
439851010254	dimerization interface [polypeptide binding]; other site
439851010255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
439851010256	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
439851010257	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
439851010258	hypothetical protein; Reviewed; Region: PRK09588
439851010259	TROVE domain; Region: TROVE; pfam05731
439851010260	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
439851010261	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
439851010262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851010263	Walker A motif; other site
439851010264	ATP binding site [chemical binding]; other site
439851010265	Walker B motif; other site
439851010266	arginine finger; other site
439851010267	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
439851010268	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439851010269	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851010270	intramembrane serine protease GlpG; Provisional; Region: PRK10907
439851010271	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
439851010272	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
439851010273	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
439851010274	active site residue [active]
439851010275	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
439851010276	hypothetical protein; Provisional; Region: PRK09781
439851010277	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
439851010278	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
439851010279	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
439851010280	dimer interface [polypeptide binding]; other site
439851010281	active site
439851010282	metal binding site [ion binding]; metal-binding site
439851010283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851010284	D-galactonate transporter; Region: 2A0114; TIGR00893
439851010285	putative substrate translocation pore; other site
439851010286	Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129
439851010287	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
439851010288	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
439851010289	inhibitor site; inhibition site
439851010290	active site
439851010291	dimer interface [polypeptide binding]; other site
439851010292	catalytic residue [active]
439851010293	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439851010294	Transcriptional regulator [Transcription]; Region: IclR; COG1414
439851010295	Bacterial transcriptional regulator; Region: IclR; pfam01614
439851010296	glycogen phosphorylase; Provisional; Region: PRK14986
439851010297	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
439851010298	homodimer interface [polypeptide binding]; other site
439851010299	active site pocket [active]
439851010300	glycogen synthase; Provisional; Region: glgA; PRK00654
439851010301	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
439851010302	ADP-binding pocket [chemical binding]; other site
439851010303	homodimer interface [polypeptide binding]; other site
439851010304	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
439851010305	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
439851010306	ligand binding site; other site
439851010307	oligomer interface; other site
439851010308	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
439851010309	dimer interface [polypeptide binding]; other site
439851010310	N-terminal domain interface [polypeptide binding]; other site
439851010311	sulfate 1 binding site; other site
439851010312	glycogen debranching enzyme; Provisional; Region: PRK03705
439851010313	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
439851010314	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
439851010315	active site
439851010316	catalytic site [active]
439851010317	glycogen branching enzyme; Provisional; Region: PRK05402
439851010318	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
439851010319	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
439851010320	active site
439851010321	catalytic site [active]
439851010322	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
439851010323	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
439851010324	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
439851010325	low affinity gluconate transporter; Provisional; Region: PRK10472
439851010326	gluconate transporter; Region: gntP; TIGR00791
439851010327	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
439851010328	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
439851010329	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851010330	DNA binding site [nucleotide binding]
439851010331	domain linker motif; other site
439851010332	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
439851010333	putative ligand binding site [chemical binding]; other site
439851010334	putative dimerization interface [polypeptide binding]; other site
439851010335	Pirin-related protein [General function prediction only]; Region: COG1741
439851010336	Pirin; Region: Pirin; pfam02678
439851010337	putative oxidoreductase; Provisional; Region: PRK10206
439851010338	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439851010339	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439851010340	putative acetyltransferase YhhY; Provisional; Region: PRK10140
439851010341	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851010342	Coenzyme A binding pocket [chemical binding]; other site
439851010343	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851010344	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851010345	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851010346	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439851010347	substrate binding site [chemical binding]; other site
439851010348	dimer interface [polypeptide binding]; other site
439851010349	ATP binding site [chemical binding]; other site
439851010350	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
439851010351	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
439851010352	Protein of unknown function, DUF606; Region: DUF606; pfam04657
439851010353	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
439851010354	active site
439851010355	substrate binding pocket [chemical binding]; other site
439851010356	homodimer interaction site [polypeptide binding]; other site
439851010357	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
439851010358	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
439851010359	hypothetical protein; Provisional; Region: PRK10350
439851010360	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
439851010361	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
439851010362	putative active site [active]
439851010363	catalytic site [active]
439851010364	putative metal binding site [ion binding]; other site
439851010365	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
439851010366	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
439851010367	Walker A/P-loop; other site
439851010368	ATP binding site [chemical binding]; other site
439851010369	Q-loop/lid; other site
439851010370	ABC transporter signature motif; other site
439851010371	Walker B; other site
439851010372	D-loop; other site
439851010373	H-loop/switch region; other site
439851010374	TOBE domain; Region: TOBE_2; pfam08402
439851010375	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
439851010376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851010377	dimer interface [polypeptide binding]; other site
439851010378	conserved gate region; other site
439851010379	ABC-ATPase subunit interface; other site
439851010380	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
439851010381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851010382	dimer interface [polypeptide binding]; other site
439851010383	conserved gate region; other site
439851010384	putative PBP binding loops; other site
439851010385	ABC-ATPase subunit interface; other site
439851010386	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
439851010387	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
439851010388	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
439851010389	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
439851010390	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
439851010391	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
439851010392	Walker A/P-loop; other site
439851010393	ATP binding site [chemical binding]; other site
439851010394	Q-loop/lid; other site
439851010395	ABC transporter signature motif; other site
439851010396	Walker B; other site
439851010397	D-loop; other site
439851010398	H-loop/switch region; other site
439851010399	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
439851010400	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
439851010401	Walker A/P-loop; other site
439851010402	ATP binding site [chemical binding]; other site
439851010403	Q-loop/lid; other site
439851010404	ABC transporter signature motif; other site
439851010405	Walker B; other site
439851010406	D-loop; other site
439851010407	H-loop/switch region; other site
439851010408	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
439851010409	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
439851010410	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
439851010411	TM-ABC transporter signature motif; other site
439851010412	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439851010413	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
439851010414	TM-ABC transporter signature motif; other site
439851010415	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
439851010416	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
439851010417	dimerization interface [polypeptide binding]; other site
439851010418	ligand binding site [chemical binding]; other site
439851010419	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
439851010420	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
439851010421	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
439851010422	dimerization interface [polypeptide binding]; other site
439851010423	ligand binding site [chemical binding]; other site
439851010424	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
439851010425	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439851010426	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439851010427	DNA binding residues [nucleotide binding]
439851010428	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
439851010429	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
439851010430	cell division protein FtsE; Provisional; Region: PRK10908
439851010431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851010432	Walker A/P-loop; other site
439851010433	ATP binding site [chemical binding]; other site
439851010434	Q-loop/lid; other site
439851010435	ABC transporter signature motif; other site
439851010436	Walker B; other site
439851010437	D-loop; other site
439851010438	H-loop/switch region; other site
439851010439	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
439851010440	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
439851010441	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
439851010442	P loop; other site
439851010443	GTP binding site [chemical binding]; other site
439851010444	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
439851010445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851010446	S-adenosylmethionine binding site [chemical binding]; other site
439851010447	hypothetical protein; Provisional; Region: PRK10910
439851010448	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
439851010449	Predicted membrane protein [Function unknown]; Region: COG3714
439851010450	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
439851010451	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439851010452	metal-binding site [ion binding]
439851010453	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439851010454	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
439851010455	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439851010456	dimer interface [polypeptide binding]; other site
439851010457	ligand binding site [chemical binding]; other site
439851010458	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851010459	dimerization interface [polypeptide binding]; other site
439851010460	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851010461	dimer interface [polypeptide binding]; other site
439851010462	putative CheW interface [polypeptide binding]; other site
439851010463	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
439851010464	CPxP  motif; other site
439851010465	hypothetical protein; Provisional; Region: PRK11212
439851010466	hypothetical protein; Provisional; Region: PRK11615
439851010467	major facilitator superfamily transporter; Provisional; Region: PRK05122
439851010468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851010469	putative substrate translocation pore; other site
439851010470	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439851010471	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
439851010472	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
439851010473	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
439851010474	nickel responsive regulator; Provisional; Region: PRK02967
439851010475	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
439851010476	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439851010477	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
439851010478	HlyD family secretion protein; Region: HlyD; pfam00529
439851010479	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851010480	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851010481	Predicted flavoproteins [General function prediction only]; Region: COG2081
439851010482	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851010483	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
439851010484	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
439851010485	universal stress protein UspB; Provisional; Region: PRK04960
439851010486	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439851010487	Ligand Binding Site [chemical binding]; other site
439851010488	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
439851010489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851010490	putative substrate translocation pore; other site
439851010491	POT family; Region: PTR2; pfam00854
439851010492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851010493	S-adenosylmethionine binding site [chemical binding]; other site
439851010494	oligopeptidase A; Provisional; Region: PRK10911
439851010495	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
439851010496	active site
439851010497	Zn binding site [ion binding]; other site
439851010498	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
439851010499	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439851010500	active site
439851010501	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
439851010502	glutathione reductase; Validated; Region: PRK06116
439851010503	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439851010504	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851010505	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439851010506	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
439851010507	active site
439851010508	homodimer interface [polypeptide binding]; other site
439851010509	homotetramer interface [polypeptide binding]; other site
439851010510	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
439851010511	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
439851010512	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
439851010513	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851010514	substrate binding site [chemical binding]; other site
439851010515	ATP binding site [chemical binding]; other site
439851010516	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
439851010517	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
439851010518	putative active site [active]
439851010519	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
439851010520	dimer interface [polypeptide binding]; other site
439851010521	active site
439851010522	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
439851010523	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851010524	DNA-binding site [nucleotide binding]; DNA binding site
439851010525	UTRA domain; Region: UTRA; pfam07702
439851010526	trehalase; Provisional; Region: treF; PRK13270
439851010527	Trehalase; Region: Trehalase; pfam01204
439851010528	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
439851010529	catalytic residue [active]
439851010530	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
439851010531	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851010532	DNA binding residues [nucleotide binding]
439851010533	dimerization interface [polypeptide binding]; other site
439851010534	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851010535	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851010536	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
439851010537	putative effector binding pocket; other site
439851010538	putative dimerization interface [polypeptide binding]; other site
439851010539	inner membrane protein YhjD; Region: TIGR00766
439851010540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851010541	metabolite-proton symporter; Region: 2A0106; TIGR00883
439851010542	putative substrate translocation pore; other site
439851010543	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
439851010544	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
439851010545	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851010546	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
439851010547	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
439851010548	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
439851010549	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439851010550	putative diguanylate cyclase; Provisional; Region: PRK13561
439851010551	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851010552	metal binding site [ion binding]; metal-binding site
439851010553	active site
439851010554	I-site; other site
439851010555	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851010556	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
439851010557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
439851010558	TPR motif; other site
439851010559	binding surface
439851010560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439851010561	TPR motif; other site
439851010562	binding surface
439851010563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439851010564	binding surface
439851010565	TPR motif; other site
439851010566	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
439851010567	endo-1,4-D-glucanase; Provisional; Region: PRK11097
439851010568	cellulose synthase regulator protein; Provisional; Region: PRK11114
439851010569	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
439851010570	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439851010571	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
439851010572	DXD motif; other site
439851010573	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439851010574	PilZ domain; Region: PilZ; pfam07238
439851010575	cell division protein; Provisional; Region: PRK10037
439851010576	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
439851010577	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
439851010578	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
439851010579	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
439851010580	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
439851010581	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
439851010582	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
439851010583	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439851010584	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
439851010585	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
439851010586	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851010587	Walker A/P-loop; other site
439851010588	ATP binding site [chemical binding]; other site
439851010589	Q-loop/lid; other site
439851010590	ABC transporter signature motif; other site
439851010591	Walker B; other site
439851010592	D-loop; other site
439851010593	H-loop/switch region; other site
439851010594	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
439851010595	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
439851010596	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439851010597	Walker A/P-loop; other site
439851010598	ATP binding site [chemical binding]; other site
439851010599	Q-loop/lid; other site
439851010600	ABC transporter signature motif; other site
439851010601	Walker B; other site
439851010602	D-loop; other site
439851010603	H-loop/switch region; other site
439851010604	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
439851010605	dipeptide transporter; Provisional; Region: PRK10913
439851010606	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439851010607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851010608	dimer interface [polypeptide binding]; other site
439851010609	conserved gate region; other site
439851010610	putative PBP binding loops; other site
439851010611	ABC-ATPase subunit interface; other site
439851010612	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
439851010613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851010614	dimer interface [polypeptide binding]; other site
439851010615	conserved gate region; other site
439851010616	putative PBP binding loops; other site
439851010617	ABC-ATPase subunit interface; other site
439851010618	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
439851010619	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
439851010620	peptide binding site [polypeptide binding]; other site
439851010621	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
439851010622	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
439851010623	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439851010624	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851010625	DNA binding site [nucleotide binding]
439851010626	domain linker motif; other site
439851010627	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
439851010628	putative dimerization interface [polypeptide binding]; other site
439851010629	putative ligand binding site [chemical binding]; other site
439851010630	phosphoethanolamine transferase; Provisional; Region: PRK11560
439851010631	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
439851010632	Sulfatase; Region: Sulfatase; pfam00884
439851010633	long polar fimbrial protein LpfE; Provisional; Region: PRK15205
439851010634	long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208
439851010635	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851010636	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851010637	long polar fimbrial protein LpfA; Provisional; Region: PRK15209
439851010638	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
439851010639	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
439851010640	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851010641	Coenzyme A binding pocket [chemical binding]; other site
439851010642	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
439851010643	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
439851010644	molybdopterin cofactor binding site [chemical binding]; other site
439851010645	substrate binding site [chemical binding]; other site
439851010646	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
439851010647	molybdopterin cofactor binding site; other site
439851010648	putative outer membrane lipoprotein; Provisional; Region: PRK10510
439851010649	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439851010650	ligand binding site [chemical binding]; other site
439851010651	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
439851010652	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
439851010653	dimerization interface [polypeptide binding]; other site
439851010654	ligand binding site [chemical binding]; other site
439851010655	NADP binding site [chemical binding]; other site
439851010656	catalytic site [active]
439851010657	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
439851010658	Predicted transcriptional regulator [Transcription]; Region: COG2944
439851010659	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851010660	salt bridge; other site
439851010661	non-specific DNA binding site [nucleotide binding]; other site
439851010662	sequence-specific DNA binding site [nucleotide binding]; other site
439851010663	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439851010664	DNA-binding site [nucleotide binding]; DNA binding site
439851010665	RNA-binding motif; other site
439851010666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
439851010667	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
439851010668	DALR anticodon binding domain; Region: DALR_1; pfam05746
439851010669	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
439851010670	dimer interface [polypeptide binding]; other site
439851010671	motif 1; other site
439851010672	active site
439851010673	motif 2; other site
439851010674	motif 3; other site
439851010675	YsaB-like lipoprotein; Region: YsaB; pfam13983
439851010676	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
439851010677	Acyltransferase family; Region: Acyl_transf_3; pfam01757
439851010678	Predicted membrane protein [Function unknown]; Region: COG4682
439851010679	yiaA/B two helix domain; Region: YiaAB; cl01759
439851010680	yiaA/B two helix domain; Region: YiaAB; cl01759
439851010681	xylulokinase; Provisional; Region: PRK15027
439851010682	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
439851010683	N- and C-terminal domain interface [polypeptide binding]; other site
439851010684	active site
439851010685	MgATP binding site [chemical binding]; other site
439851010686	catalytic site [active]
439851010687	metal binding site [ion binding]; metal-binding site
439851010688	xylulose binding site [chemical binding]; other site
439851010689	homodimer interface [polypeptide binding]; other site
439851010690	xylose isomerase; Provisional; Region: PRK05474
439851010691	xylose isomerase; Region: xylose_isom_A; TIGR02630
439851010692	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
439851010693	putative dimerization interface [polypeptide binding]; other site
439851010694	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439851010695	putative ligand binding site [chemical binding]; other site
439851010696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851010697	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851010698	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851010699	hypothetical protein; Provisional; Region: PRK10356
439851010700	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
439851010701	alpha-amylase; Reviewed; Region: malS; PRK09505
439851010702	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
439851010703	active site
439851010704	catalytic site [active]
439851010705	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
439851010706	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851010707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851010708	homodimer interface [polypeptide binding]; other site
439851010709	catalytic residue [active]
439851010710	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
439851010711	Transcriptional regulator [Transcription]; Region: IclR; COG1414
439851010712	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439851010713	Bacterial transcriptional regulator; Region: IclR; pfam01614
439851010714	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
439851010715	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
439851010716	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
439851010717	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
439851010718	DctM-like transporters; Region: DctM; pfam06808
439851010719	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
439851010720	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
439851010721	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
439851010722	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
439851010723	putative N- and C-terminal domain interface [polypeptide binding]; other site
439851010724	putative active site [active]
439851010725	MgATP binding site [chemical binding]; other site
439851010726	catalytic site [active]
439851010727	metal binding site [ion binding]; metal-binding site
439851010728	putative xylulose binding site [chemical binding]; other site
439851010729	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
439851010730	active site
439851010731	dimer interface [polypeptide binding]; other site
439851010732	magnesium binding site [ion binding]; other site
439851010733	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
439851010734	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
439851010735	AP (apurinic/apyrimidinic) site pocket; other site
439851010736	DNA interaction; other site
439851010737	Metal-binding active site; metal-binding site
439851010738	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
439851010739	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439851010740	intersubunit interface [polypeptide binding]; other site
439851010741	active site
439851010742	Zn2+ binding site [ion binding]; other site
439851010743	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439851010744	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
439851010745	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851010746	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
439851010747	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
439851010748	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
439851010749	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
439851010750	NAD(P) binding site [chemical binding]; other site
439851010751	catalytic residues [active]
439851010752	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
439851010753	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439851010754	nucleotide binding site [chemical binding]; other site
439851010755	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
439851010756	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
439851010757	G1 box; other site
439851010758	putative GEF interaction site [polypeptide binding]; other site
439851010759	GTP/Mg2+ binding site [chemical binding]; other site
439851010760	Switch I region; other site
439851010761	G2 box; other site
439851010762	G3 box; other site
439851010763	Switch II region; other site
439851010764	G4 box; other site
439851010765	G5 box; other site
439851010766	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
439851010767	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
439851010768	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
439851010769	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
439851010770	selenocysteine synthase; Provisional; Region: PRK04311
439851010771	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
439851010772	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
439851010773	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851010774	catalytic residue [active]
439851010775	putative glutathione S-transferase; Provisional; Region: PRK10357
439851010776	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
439851010777	putative C-terminal domain interface [polypeptide binding]; other site
439851010778	putative GSH binding site (G-site) [chemical binding]; other site
439851010779	putative dimer interface [polypeptide binding]; other site
439851010780	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
439851010781	dimer interface [polypeptide binding]; other site
439851010782	N-terminal domain interface [polypeptide binding]; other site
439851010783	putative substrate binding pocket (H-site) [chemical binding]; other site
439851010784	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
439851010785	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
439851010786	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
439851010787	active site
439851010788	P-loop; other site
439851010789	phosphorylation site [posttranslational modification]
439851010790	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851010791	active site
439851010792	phosphorylation site [posttranslational modification]
439851010793	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
439851010794	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
439851010795	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
439851010796	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
439851010797	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
439851010798	hypothetical protein; Provisional; Region: PRK11020
439851010799	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
439851010800	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
439851010801	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
439851010802	trimer interface [polypeptide binding]; other site
439851010803	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
439851010804	Haemagglutinin; Region: HIM; pfam05662
439851010805	Haemagglutinin; Region: HIM; pfam05662
439851010806	YadA-like C-terminal region; Region: YadA; pfam03895
439851010807	L-lactate permease; Provisional; Region: PRK10420
439851010808	glycolate transporter; Provisional; Region: PRK09695
439851010809	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
439851010810	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851010811	DNA-binding site [nucleotide binding]; DNA binding site
439851010812	FCD domain; Region: FCD; pfam07729
439851010813	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
439851010814	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
439851010815	active site
439851010816	substrate binding site [chemical binding]; other site
439851010817	FMN binding site [chemical binding]; other site
439851010818	putative catalytic residues [active]
439851010819	putative rRNA methylase; Provisional; Region: PRK10358
439851010820	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439851010821	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851010822	DNA binding site [nucleotide binding]
439851010823	domain linker motif; other site
439851010824	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
439851010825	putative dimerization interface [polypeptide binding]; other site
439851010826	putative ligand binding site [chemical binding]; other site
439851010827	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
439851010828	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
439851010829	active site pocket [active]
439851010830	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851010831	D-galactonate transporter; Region: 2A0114; TIGR00893
439851010832	putative substrate translocation pore; other site
439851010833	serine acetyltransferase; Provisional; Region: cysE; PRK11132
439851010834	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
439851010835	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
439851010836	trimer interface [polypeptide binding]; other site
439851010837	active site
439851010838	substrate binding site [chemical binding]; other site
439851010839	CoA binding site [chemical binding]; other site
439851010840	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
439851010841	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
439851010842	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
439851010843	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
439851010844	SecA binding site; other site
439851010845	Preprotein binding site; other site
439851010846	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
439851010847	GSH binding site [chemical binding]; other site
439851010848	catalytic residues [active]
439851010849	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
439851010850	active site residue [active]
439851010851	phosphoglyceromutase; Provisional; Region: PRK05434
439851010852	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
439851010853	AmiB activator; Provisional; Region: PRK11637
439851010854	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
439851010855	Peptidase family M23; Region: Peptidase_M23; pfam01551
439851010856	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
439851010857	NodB motif; other site
439851010858	putative active site [active]
439851010859	putative catalytic site [active]
439851010860	Zn binding site [ion binding]; other site
439851010861	putative glycosyl transferase; Provisional; Region: PRK10073
439851010862	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
439851010863	active site
439851010864	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
439851010865	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
439851010866	NAD(P) binding site [chemical binding]; other site
439851010867	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
439851010868	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
439851010869	substrate-cofactor binding pocket; other site
439851010870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851010871	catalytic residue [active]
439851010872	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
439851010873	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
439851010874	NADP binding site [chemical binding]; other site
439851010875	homopentamer interface [polypeptide binding]; other site
439851010876	substrate binding site [chemical binding]; other site
439851010877	active site
439851010878	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
439851010879	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
439851010880	putative active site [active]
439851010881	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
439851010882	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
439851010883	putative active site [active]
439851010884	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
439851010885	O-antigen ligase RfaL; Provisional; Region: PRK15487
439851010886	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
439851010887	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
439851010888	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
439851010889	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
439851010890	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
439851010891	Ligand binding site; other site
439851010892	metal-binding site
439851010893	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
439851010894	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
439851010895	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
439851010896	Ligand binding site; other site
439851010897	metal-binding site
439851010898	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
439851010899	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
439851010900	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
439851010901	putative ADP-binding pocket [chemical binding]; other site
439851010902	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439851010903	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
439851010904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
439851010905	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
439851010906	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
439851010907	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
439851010908	putative active site [active]
439851010909	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
439851010910	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
439851010911	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
439851010912	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
439851010913	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
439851010914	active site
439851010915	(T/H)XGH motif; other site
439851010916	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
439851010917	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
439851010918	DNA binding site [nucleotide binding]
439851010919	catalytic residue [active]
439851010920	H2TH interface [polypeptide binding]; other site
439851010921	putative catalytic residues [active]
439851010922	turnover-facilitating residue; other site
439851010923	intercalation triad [nucleotide binding]; other site
439851010924	8OG recognition residue [nucleotide binding]; other site
439851010925	putative reading head residues; other site
439851010926	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
439851010927	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
439851010928	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
439851010929	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
439851010930	hypothetical protein; Reviewed; Region: PRK00024
439851010931	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
439851010932	MPN+ (JAMM) motif; other site
439851010933	Zinc-binding site [ion binding]; other site
439851010934	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
439851010935	trimer interface [polypeptide binding]; other site
439851010936	active site
439851010937	division inhibitor protein; Provisional; Region: slmA; PRK09480
439851010938	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851010939	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439851010940	active site
439851010941	ribonuclease PH; Reviewed; Region: rph; PRK00173
439851010942	Ribonuclease PH; Region: RNase_PH_bact; cd11362
439851010943	hexamer interface [polypeptide binding]; other site
439851010944	active site
439851010945	hypothetical protein; Provisional; Region: PRK11820
439851010946	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
439851010947	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
439851010948	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851010949	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851010950	dimerization interface [polypeptide binding]; other site
439851010951	LysR substrate binding domain; Region: LysR_substrate; pfam03466
439851010952	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
439851010953	Predicted membrane protein [Function unknown]; Region: COG2860
439851010954	UPF0126 domain; Region: UPF0126; pfam03458
439851010955	UPF0126 domain; Region: UPF0126; pfam03458
439851010956	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
439851010957	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
439851010958	nucleotide binding pocket [chemical binding]; other site
439851010959	K-X-D-G motif; other site
439851010960	catalytic site [active]
439851010961	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
439851010962	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
439851010963	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
439851010964	catalytic site [active]
439851010965	G-X2-G-X-G-K; other site
439851010966	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
439851010967	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
439851010968	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439851010969	Zn2+ binding site [ion binding]; other site
439851010970	Mg2+ binding site [ion binding]; other site
439851010971	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
439851010972	synthetase active site [active]
439851010973	NTP binding site [chemical binding]; other site
439851010974	metal binding site [ion binding]; metal-binding site
439851010975	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
439851010976	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
439851010977	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
439851010978	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
439851010979	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
439851010980	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
439851010981	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
439851010982	generic binding surface II; other site
439851010983	ssDNA binding site; other site
439851010984	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851010985	ATP binding site [chemical binding]; other site
439851010986	putative Mg++ binding site [ion binding]; other site
439851010987	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851010988	nucleotide binding region [chemical binding]; other site
439851010989	ATP-binding site [chemical binding]; other site
439851010990	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
439851010991	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
439851010992	AsmA family; Region: AsmA; pfam05170
439851010993	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
439851010994	putative alpha-glucosidase; Provisional; Region: PRK10658
439851010995	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
439851010996	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
439851010997	active site
439851010998	homotrimer interface [polypeptide binding]; other site
439851010999	catalytic site [active]
439851011000	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
439851011001	Virulence protein [General function prediction only]; Region: COG3943
439851011002	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
439851011003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
439851011004	Transposase; Region: HTH_Tnp_1; pfam01527
439851011005	Isochorismatase family; Region: Isochorismatase; pfam00857
439851011006	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
439851011007	catalytic triad [active]
439851011008	dimer interface [polypeptide binding]; other site
439851011009	conserved cis-peptide bond; other site
439851011010	magnesium-transporting ATPase; Provisional; Region: PRK15122
439851011011	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
439851011012	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439851011013	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
439851011014	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011015	motif II; other site
439851011016	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
439851011017	magnesium transport protein MgtC; Provisional; Region: PRK15385
439851011018	MgtC family; Region: MgtC; pfam02308
439851011019	EamA-like transporter family; Region: EamA; pfam00892
439851011020	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
439851011021	EamA-like transporter family; Region: EamA; pfam00892
439851011022	hypothetical protein; Provisional; Region: PRK09956
439851011023	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
439851011024	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
439851011025	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
439851011026	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
439851011027	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
439851011028	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
439851011029	active site
439851011030	phosphorylation site [posttranslational modification]
439851011031	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439851011032	active pocket/dimerization site; other site
439851011033	active site
439851011034	phosphorylation site [posttranslational modification]
439851011035	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
439851011036	beta-galactosidase; Region: BGL; TIGR03356
439851011037	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
439851011038	Predicted transcriptional regulator [Transcription]; Region: COG2944
439851011039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851011040	non-specific DNA binding site [nucleotide binding]; other site
439851011041	salt bridge; other site
439851011042	sequence-specific DNA binding site [nucleotide binding]; other site
439851011043	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
439851011044	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
439851011045	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011046	putative substrate translocation pore; other site
439851011047	regulatory protein UhpC; Provisional; Region: PRK11663
439851011048	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011049	putative substrate translocation pore; other site
439851011050	sensory histidine kinase UhpB; Provisional; Region: PRK11644
439851011051	MASE1; Region: MASE1; pfam05231
439851011052	Histidine kinase; Region: HisKA_3; pfam07730
439851011053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851011054	ATP binding site [chemical binding]; other site
439851011055	Mg2+ binding site [ion binding]; other site
439851011056	G-X-G motif; other site
439851011057	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
439851011058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851011059	active site
439851011060	phosphorylation site [posttranslational modification]
439851011061	intermolecular recognition site; other site
439851011062	dimerization interface [polypeptide binding]; other site
439851011063	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851011064	DNA binding residues [nucleotide binding]
439851011065	dimerization interface [polypeptide binding]; other site
439851011066	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
439851011067	active site
439851011068	catalytic residues [active]
439851011069	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
439851011070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011071	putative substrate translocation pore; other site
439851011072	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851011073	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439851011074	substrate binding site [chemical binding]; other site
439851011075	dimer interface [polypeptide binding]; other site
439851011076	ATP binding site [chemical binding]; other site
439851011077	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
439851011078	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
439851011079	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851011080	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
439851011081	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
439851011082	putative valine binding site [chemical binding]; other site
439851011083	dimer interface [polypeptide binding]; other site
439851011084	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
439851011085	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
439851011086	PYR/PP interface [polypeptide binding]; other site
439851011087	dimer interface [polypeptide binding]; other site
439851011088	TPP binding site [chemical binding]; other site
439851011089	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439851011090	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
439851011091	TPP-binding site [chemical binding]; other site
439851011092	dimer interface [polypeptide binding]; other site
439851011093	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
439851011094	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
439851011095	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
439851011096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011097	putative substrate translocation pore; other site
439851011098	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
439851011099	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851011100	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
439851011101	dimerization interface [polypeptide binding]; other site
439851011102	substrate binding pocket [chemical binding]; other site
439851011103	permease DsdX; Provisional; Region: PRK09921
439851011104	gluconate transporter; Region: gntP; TIGR00791
439851011105	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
439851011106	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
439851011107	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439851011108	catalytic residue [active]
439851011109	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
439851011110	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
439851011111	Domain of unknown function (DUF202); Region: DUF202; pfam02656
439851011112	Predicted membrane protein [Function unknown]; Region: COG2149
439851011113	putative transporter; Validated; Region: PRK03818
439851011114	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
439851011115	TrkA-C domain; Region: TrkA_C; pfam02080
439851011116	TrkA-C domain; Region: TrkA_C; pfam02080
439851011117	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
439851011118	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
439851011119	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
439851011120	putative dimer interface [polypeptide binding]; other site
439851011121	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
439851011122	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
439851011123	putative dimer interface [polypeptide binding]; other site
439851011124	hypothetical protein; Provisional; Region: PRK11616
439851011125	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
439851011126	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
439851011127	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
439851011128	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
439851011129	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
439851011130	catalytic residues [active]
439851011131	central insert; other site
439851011132	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
439851011133	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
439851011134	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
439851011135	heme exporter protein CcmC; Region: ccmC; TIGR01191
439851011136	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
439851011137	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
439851011138	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851011139	Walker A/P-loop; other site
439851011140	ATP binding site [chemical binding]; other site
439851011141	Q-loop/lid; other site
439851011142	ABC transporter signature motif; other site
439851011143	Walker B; other site
439851011144	D-loop; other site
439851011145	H-loop/switch region; other site
439851011146	Haem-binding domain; Region: Haem_bd; pfam14376
439851011147	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
439851011148	chaperone protein TorD; Validated; Region: torD; PRK04976
439851011149	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
439851011150	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
439851011151	molybdopterin cofactor binding site [chemical binding]; other site
439851011152	substrate binding site [chemical binding]; other site
439851011153	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
439851011154	molybdopterin cofactor binding site; other site
439851011155	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
439851011156	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
439851011157	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
439851011158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851011159	active site
439851011160	phosphorylation site [posttranslational modification]
439851011161	intermolecular recognition site; other site
439851011162	dimerization interface [polypeptide binding]; other site
439851011163	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851011164	DNA binding site [nucleotide binding]
439851011165	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
439851011166	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
439851011167	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
439851011168	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851011169	dimer interface [polypeptide binding]; other site
439851011170	phosphorylation site [posttranslational modification]
439851011171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851011172	ATP binding site [chemical binding]; other site
439851011173	Mg2+ binding site [ion binding]; other site
439851011174	G-X-G motif; other site
439851011175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851011176	active site
439851011177	phosphorylation site [posttranslational modification]
439851011178	intermolecular recognition site; other site
439851011179	dimerization interface [polypeptide binding]; other site
439851011180	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439851011181	putative binding surface; other site
439851011182	active site
439851011183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011184	D-galactonate transporter; Region: 2A0114; TIGR00893
439851011185	putative substrate translocation pore; other site
439851011186	galactonate dehydratase; Provisional; Region: PRK14017
439851011187	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
439851011188	putative active site pocket [active]
439851011189	putative metal binding site [ion binding]; other site
439851011190	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
439851011191	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
439851011192	active site
439851011193	intersubunit interface [polypeptide binding]; other site
439851011194	catalytic residue [active]
439851011195	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
439851011196	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
439851011197	Transcriptional regulators [Transcription]; Region: FadR; COG2186
439851011198	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851011199	DNA-binding site [nucleotide binding]; DNA binding site
439851011200	FCD domain; Region: FCD; pfam07729
439851011201	sugar phosphate phosphatase; Provisional; Region: PRK10513
439851011202	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011203	active site
439851011204	motif I; other site
439851011205	motif II; other site
439851011206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011208	D-galactonate transporter; Region: 2A0114; TIGR00893
439851011209	putative substrate translocation pore; other site
439851011210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011211	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
439851011212	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
439851011213	active site pocket [active]
439851011214	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
439851011215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851011216	Mg2+ binding site [ion binding]; other site
439851011217	G-X-G motif; other site
439851011218	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
439851011219	anchoring element; other site
439851011220	dimer interface [polypeptide binding]; other site
439851011221	ATP binding site [chemical binding]; other site
439851011222	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
439851011223	active site
439851011224	putative metal-binding site [ion binding]; other site
439851011225	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
439851011226	recF protein; Region: recf; TIGR00611
439851011227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851011228	Walker A/P-loop; other site
439851011229	ATP binding site [chemical binding]; other site
439851011230	Q-loop/lid; other site
439851011231	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851011232	ABC transporter signature motif; other site
439851011233	Walker B; other site
439851011234	D-loop; other site
439851011235	H-loop/switch region; other site
439851011236	DNA polymerase III subunit beta; Validated; Region: PRK05643
439851011237	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
439851011238	putative DNA binding surface [nucleotide binding]; other site
439851011239	dimer interface [polypeptide binding]; other site
439851011240	beta-clamp/clamp loader binding surface; other site
439851011241	beta-clamp/translesion DNA polymerase binding surface; other site
439851011242	DnaA N-terminal domain; Region: DnaA_N; pfam11638
439851011243	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
439851011244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851011245	Walker A motif; other site
439851011246	ATP binding site [chemical binding]; other site
439851011247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
439851011248	Walker B motif; other site
439851011249	arginine finger; other site
439851011250	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
439851011251	DnaA box-binding interface [nucleotide binding]; other site
439851011252	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
439851011253	ribonuclease P; Reviewed; Region: rnpA; PRK01732
439851011254	membrane protein insertase; Provisional; Region: PRK01318
439851011255	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
439851011256	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
439851011257	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
439851011258	trmE is a tRNA modification GTPase; Region: trmE; cd04164
439851011259	G1 box; other site
439851011260	GTP/Mg2+ binding site [chemical binding]; other site
439851011261	Switch I region; other site
439851011262	G2 box; other site
439851011263	Switch II region; other site
439851011264	G3 box; other site
439851011265	G4 box; other site
439851011266	G5 box; other site
439851011267	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
439851011268	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
439851011269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011270	putative substrate translocation pore; other site
439851011271	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
439851011272	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851011273	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
439851011274	substrate binding pocket [chemical binding]; other site
439851011275	dimerization interface [polypeptide binding]; other site
439851011276	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
439851011277	Predicted flavoprotein [General function prediction only]; Region: COG0431
439851011278	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
439851011279	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
439851011280	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
439851011281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011282	active site
439851011283	motif I; other site
439851011284	motif II; other site
439851011285	transcriptional regulator PhoU; Provisional; Region: PRK11115
439851011286	PhoU domain; Region: PhoU; pfam01895
439851011287	PhoU domain; Region: PhoU; pfam01895
439851011288	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
439851011289	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
439851011290	Walker A/P-loop; other site
439851011291	ATP binding site [chemical binding]; other site
439851011292	Q-loop/lid; other site
439851011293	ABC transporter signature motif; other site
439851011294	Walker B; other site
439851011295	D-loop; other site
439851011296	H-loop/switch region; other site
439851011297	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
439851011298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851011299	dimer interface [polypeptide binding]; other site
439851011300	conserved gate region; other site
439851011301	putative PBP binding loops; other site
439851011302	ABC-ATPase subunit interface; other site
439851011303	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
439851011304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851011305	dimer interface [polypeptide binding]; other site
439851011306	conserved gate region; other site
439851011307	putative PBP binding loops; other site
439851011308	ABC-ATPase subunit interface; other site
439851011309	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851011310	substrate binding pocket [chemical binding]; other site
439851011311	membrane-bound complex binding site; other site
439851011312	hinge residues; other site
439851011313	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
439851011314	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
439851011315	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
439851011316	shikimate binding site; other site
439851011317	NAD(P) binding site [chemical binding]; other site
439851011318	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
439851011319	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
439851011320	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
439851011321	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
439851011322	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
439851011323	glutaminase active site [active]
439851011324	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
439851011325	dimer interface [polypeptide binding]; other site
439851011326	active site
439851011327	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
439851011328	dimer interface [polypeptide binding]; other site
439851011329	active site
439851011330	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
439851011331	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
439851011332	Substrate binding site; other site
439851011333	Mg++ binding site; other site
439851011334	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
439851011335	active site
439851011336	substrate binding site [chemical binding]; other site
439851011337	CoA binding site [chemical binding]; other site
439851011338	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439851011339	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
439851011340	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
439851011341	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
439851011342	gamma subunit interface [polypeptide binding]; other site
439851011343	epsilon subunit interface [polypeptide binding]; other site
439851011344	LBP interface [polypeptide binding]; other site
439851011345	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
439851011346	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
439851011347	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
439851011348	alpha subunit interaction interface [polypeptide binding]; other site
439851011349	Walker A motif; other site
439851011350	ATP binding site [chemical binding]; other site
439851011351	Walker B motif; other site
439851011352	inhibitor binding site; inhibition site
439851011353	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
439851011354	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
439851011355	core domain interface [polypeptide binding]; other site
439851011356	delta subunit interface [polypeptide binding]; other site
439851011357	epsilon subunit interface [polypeptide binding]; other site
439851011358	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
439851011359	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
439851011360	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
439851011361	beta subunit interaction interface [polypeptide binding]; other site
439851011362	Walker A motif; other site
439851011363	ATP binding site [chemical binding]; other site
439851011364	Walker B motif; other site
439851011365	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
439851011366	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
439851011367	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
439851011368	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
439851011369	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
439851011370	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
439851011371	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
439851011372	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
439851011373	ATP synthase I chain; Region: ATP_synt_I; cl09170
439851011374	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
439851011375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851011376	S-adenosylmethionine binding site [chemical binding]; other site
439851011377	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
439851011378	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
439851011379	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
439851011380	FMN-binding protein MioC; Provisional; Region: PRK09004
439851011381	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
439851011382	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439851011383	putative DNA binding site [nucleotide binding]; other site
439851011384	putative Zn2+ binding site [ion binding]; other site
439851011385	AsnC family; Region: AsnC_trans_reg; pfam01037
439851011386	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
439851011387	dimer interface [polypeptide binding]; other site
439851011388	active site
439851011389	hypothetical protein; Provisional; Region: yieM; PRK10997
439851011390	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
439851011391	metal ion-dependent adhesion site (MIDAS); other site
439851011392	regulatory ATPase RavA; Provisional; Region: PRK13531
439851011393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851011394	Walker A motif; other site
439851011395	ATP binding site [chemical binding]; other site
439851011396	Walker B motif; other site
439851011397	arginine finger; other site
439851011398	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
439851011399	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
439851011400	potassium uptake protein; Region: kup; TIGR00794
439851011401	D-ribose pyranase; Provisional; Region: PRK11797
439851011402	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
439851011403	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
439851011404	Walker A/P-loop; other site
439851011405	ATP binding site [chemical binding]; other site
439851011406	Q-loop/lid; other site
439851011407	ABC transporter signature motif; other site
439851011408	Walker B; other site
439851011409	D-loop; other site
439851011410	H-loop/switch region; other site
439851011411	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
439851011412	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439851011413	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439851011414	TM-ABC transporter signature motif; other site
439851011415	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
439851011416	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
439851011417	ligand binding site [chemical binding]; other site
439851011418	dimerization interface [polypeptide binding]; other site
439851011419	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851011420	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439851011421	substrate binding site [chemical binding]; other site
439851011422	dimer interface [polypeptide binding]; other site
439851011423	ATP binding site [chemical binding]; other site
439851011424	transcriptional repressor RbsR; Provisional; Region: PRK10423
439851011425	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851011426	DNA binding site [nucleotide binding]
439851011427	domain linker motif; other site
439851011428	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
439851011429	dimerization interface [polypeptide binding]; other site
439851011430	ligand binding site [chemical binding]; other site
439851011431	putative transporter; Provisional; Region: PRK10504
439851011432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011433	putative substrate translocation pore; other site
439851011434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011435	Transcriptional regulators [Transcription]; Region: FadR; COG2186
439851011436	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851011437	DNA-binding site [nucleotide binding]; DNA binding site
439851011438	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439851011439	transcriptional regulator HdfR; Provisional; Region: PRK03601
439851011440	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851011441	LysR substrate binding domain; Region: LysR_substrate; pfam03466
439851011442	dimerization interface [polypeptide binding]; other site
439851011443	hypothetical protein; Provisional; Region: PRK11027
439851011444	putative ATP-dependent protease; Provisional; Region: PRK09862
439851011445	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
439851011446	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851011447	Walker A motif; other site
439851011448	ATP binding site [chemical binding]; other site
439851011449	Walker B motif; other site
439851011450	arginine finger; other site
439851011451	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
439851011452	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
439851011453	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
439851011454	PYR/PP interface [polypeptide binding]; other site
439851011455	dimer interface [polypeptide binding]; other site
439851011456	TPP binding site [chemical binding]; other site
439851011457	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439851011458	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
439851011459	TPP-binding site [chemical binding]; other site
439851011460	dimer interface [polypeptide binding]; other site
439851011461	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
439851011462	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
439851011463	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
439851011464	homodimer interface [polypeptide binding]; other site
439851011465	substrate-cofactor binding pocket; other site
439851011466	catalytic residue [active]
439851011467	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
439851011468	threonine dehydratase; Reviewed; Region: PRK09224
439851011469	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
439851011470	tetramer interface [polypeptide binding]; other site
439851011471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851011472	catalytic residue [active]
439851011473	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
439851011474	putative Ile/Val binding site [chemical binding]; other site
439851011475	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
439851011476	putative Ile/Val binding site [chemical binding]; other site
439851011477	Phage-related protein [Function unknown]; Region: COG4679
439851011478	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
439851011479	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851011480	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
439851011481	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
439851011482	putative dimerization interface [polypeptide binding]; other site
439851011483	ketol-acid reductoisomerase; Validated; Region: PRK05225
439851011484	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
439851011485	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
439851011486	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
439851011487	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
439851011488	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
439851011489	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
439851011490	Part of AAA domain; Region: AAA_19; pfam13245
439851011491	Family description; Region: UvrD_C_2; pfam13538
439851011492	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
439851011493	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
439851011494	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
439851011495	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439851011496	ATP binding site [chemical binding]; other site
439851011497	Mg++ binding site [ion binding]; other site
439851011498	motif III; other site
439851011499	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851011500	nucleotide binding region [chemical binding]; other site
439851011501	ATP-binding site [chemical binding]; other site
439851011502	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
439851011503	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
439851011504	catalytic residues [active]
439851011505	transcription termination factor Rho; Provisional; Region: rho; PRK09376
439851011506	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
439851011507	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
439851011508	RNA binding site [nucleotide binding]; other site
439851011509	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
439851011510	multimer interface [polypeptide binding]; other site
439851011511	Walker A motif; other site
439851011512	ATP binding site [chemical binding]; other site
439851011513	Walker B motif; other site
439851011514	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
439851011515	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
439851011516	Mg++ binding site [ion binding]; other site
439851011517	putative catalytic motif [active]
439851011518	substrate binding site [chemical binding]; other site
439851011519	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
439851011520	Chain length determinant protein; Region: Wzz; pfam02706
439851011521	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
439851011522	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
439851011523	active site
439851011524	homodimer interface [polypeptide binding]; other site
439851011525	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
439851011526	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
439851011527	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
439851011528	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
439851011529	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
439851011530	NAD binding site [chemical binding]; other site
439851011531	substrate binding site [chemical binding]; other site
439851011532	homodimer interface [polypeptide binding]; other site
439851011533	active site
439851011534	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
439851011535	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439851011536	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
439851011537	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
439851011538	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
439851011539	inhibitor-cofactor binding pocket; inhibition site
439851011540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851011541	catalytic residue [active]
439851011542	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
439851011543	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
439851011544	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
439851011545	putative common antigen polymerase; Provisional; Region: PRK02975
439851011546	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
439851011547	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
439851011548	putative transport protein YifK; Provisional; Region: PRK10746
439851011549	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
439851011550	HemY protein N-terminus; Region: HemY_N; pfam07219
439851011551	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
439851011552	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
439851011553	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
439851011554	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
439851011555	active site
439851011556	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
439851011557	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
439851011558	domain interfaces; other site
439851011559	active site
439851011560	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
439851011561	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
439851011562	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
439851011563	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
439851011564	putative iron binding site [ion binding]; other site
439851011565	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
439851011566	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
439851011567	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
439851011568	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
439851011569	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
439851011570	hypothetical protein; Provisional; Region: PRK10963
439851011571	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
439851011572	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
439851011573	active site
439851011574	Int/Topo IB signature motif; other site
439851011575	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
439851011576	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011577	motif II; other site
439851011578	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
439851011579	Part of AAA domain; Region: AAA_19; pfam13245
439851011580	Family description; Region: UvrD_C_2; pfam13538
439851011581	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
439851011582	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
439851011583	Cl binding site [ion binding]; other site
439851011584	oligomer interface [polypeptide binding]; other site
439851011585	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
439851011586	EamA-like transporter family; Region: EamA; cl17759
439851011587	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
439851011588	CoenzymeA binding site [chemical binding]; other site
439851011589	subunit interaction site [polypeptide binding]; other site
439851011590	PHB binding site; other site
439851011591	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
439851011592	dimerization interface [polypeptide binding]; other site
439851011593	substrate binding site [chemical binding]; other site
439851011594	active site
439851011595	calcium binding site [ion binding]; other site
439851011596	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
439851011597	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851011598	ATP binding site [chemical binding]; other site
439851011599	putative Mg++ binding site [ion binding]; other site
439851011600	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439851011601	nucleotide binding region [chemical binding]; other site
439851011602	ATP-binding site [chemical binding]; other site
439851011603	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
439851011604	Helicase and RNase D C-terminal; Region: HRDC; smart00341
439851011605	threonine efflux system; Provisional; Region: PRK10229
439851011606	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
439851011607	lysophospholipase L2; Provisional; Region: PRK10749
439851011608	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
439851011609	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
439851011610	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851011611	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
439851011612	putative dimerization interface [polypeptide binding]; other site
439851011613	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
439851011614	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
439851011615	THF binding site; other site
439851011616	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
439851011617	substrate binding site [chemical binding]; other site
439851011618	THF binding site; other site
439851011619	zinc-binding site [ion binding]; other site
439851011620	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439851011621	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851011622	FeS/SAM binding site; other site
439851011623	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439851011624	uridine phosphorylase; Provisional; Region: PRK11178
439851011625	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
439851011626	DNA recombination protein RmuC; Provisional; Region: PRK10361
439851011627	RmuC family; Region: RmuC; pfam02646
439851011628	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
439851011629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851011630	S-adenosylmethionine binding site [chemical binding]; other site
439851011631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
439851011632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
439851011633	SCP-2 sterol transfer family; Region: SCP2; pfam02036
439851011634	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
439851011635	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
439851011636	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
439851011637	sec-independent translocase; Provisional; Region: PRK01770
439851011638	sec-independent translocase; Provisional; Region: tatB; PRK00404
439851011639	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
439851011640	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
439851011641	active site
439851011642	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
439851011643	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
439851011644	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
439851011645	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
439851011646	FMN reductase; Validated; Region: fre; PRK08051
439851011647	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
439851011648	FAD binding pocket [chemical binding]; other site
439851011649	FAD binding motif [chemical binding]; other site
439851011650	phosphate binding motif [ion binding]; other site
439851011651	beta-alpha-beta structure motif; other site
439851011652	NAD binding pocket [chemical binding]; other site
439851011653	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439851011654	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
439851011655	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
439851011656	dimer interface [polypeptide binding]; other site
439851011657	active site
439851011658	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
439851011659	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439851011660	substrate binding site [chemical binding]; other site
439851011661	oxyanion hole (OAH) forming residues; other site
439851011662	trimer interface [polypeptide binding]; other site
439851011663	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
439851011664	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
439851011665	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
439851011666	proline dipeptidase; Provisional; Region: PRK13607
439851011667	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
439851011668	active site
439851011669	hypothetical protein; Provisional; Region: PRK11568
439851011670	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
439851011671	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
439851011672	potassium transporter; Provisional; Region: PRK10750
439851011673	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
439851011674	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
439851011675	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
439851011676	Walker A motif; other site
439851011677	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
439851011678	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
439851011679	GTP binding site; other site
439851011680	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
439851011681	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
439851011682	serine/threonine protein kinase; Provisional; Region: PRK11768
439851011683	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
439851011684	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439851011685	catalytic residues [active]
439851011686	hinge region; other site
439851011687	alpha helical domain; other site
439851011688	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
439851011689	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
439851011690	putative acyl-acceptor binding pocket; other site
439851011691	DNA polymerase I; Provisional; Region: PRK05755
439851011692	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
439851011693	active site
439851011694	metal binding site 1 [ion binding]; metal-binding site
439851011695	putative 5' ssDNA interaction site; other site
439851011696	metal binding site 3; metal-binding site
439851011697	metal binding site 2 [ion binding]; metal-binding site
439851011698	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
439851011699	putative DNA binding site [nucleotide binding]; other site
439851011700	putative metal binding site [ion binding]; other site
439851011701	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
439851011702	active site
439851011703	catalytic site [active]
439851011704	substrate binding site [chemical binding]; other site
439851011705	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
439851011706	active site
439851011707	DNA binding site [nucleotide binding]
439851011708	catalytic site [active]
439851011709	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
439851011710	G1 box; other site
439851011711	GTP/Mg2+ binding site [chemical binding]; other site
439851011712	Switch I region; other site
439851011713	G2 box; other site
439851011714	G3 box; other site
439851011715	Switch II region; other site
439851011716	G4 box; other site
439851011717	G5 box; other site
439851011718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
439851011719	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
439851011720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851011721	FeS/SAM binding site; other site
439851011722	HemN C-terminal domain; Region: HemN_C; pfam06969
439851011723	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
439851011724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851011725	active site
439851011726	phosphorylation site [posttranslational modification]
439851011727	intermolecular recognition site; other site
439851011728	dimerization interface [polypeptide binding]; other site
439851011729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851011730	Walker A motif; other site
439851011731	ATP binding site [chemical binding]; other site
439851011732	Walker B motif; other site
439851011733	arginine finger; other site
439851011734	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439851011735	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
439851011736	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439851011737	putative active site [active]
439851011738	heme pocket [chemical binding]; other site
439851011739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851011740	dimer interface [polypeptide binding]; other site
439851011741	phosphorylation site [posttranslational modification]
439851011742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851011743	ATP binding site [chemical binding]; other site
439851011744	Mg2+ binding site [ion binding]; other site
439851011745	G-X-G motif; other site
439851011746	glutamine synthetase; Provisional; Region: glnA; PRK09469
439851011747	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
439851011748	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
439851011749	GTP-binding protein; Provisional; Region: PRK10218
439851011750	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
439851011751	G1 box; other site
439851011752	putative GEF interaction site [polypeptide binding]; other site
439851011753	GTP/Mg2+ binding site [chemical binding]; other site
439851011754	Switch I region; other site
439851011755	G2 box; other site
439851011756	G3 box; other site
439851011757	Switch II region; other site
439851011758	G4 box; other site
439851011759	G5 box; other site
439851011760	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
439851011761	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
439851011762	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011763	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
439851011764	active site
439851011765	motif I; other site
439851011766	motif II; other site
439851011767	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011768	Sulfatase; Region: Sulfatase; cl17466
439851011769	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
439851011770	outer membrane porin L; Provisional; Region: ompL; PRK09980
439851011771	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
439851011772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851011773	putative substrate translocation pore; other site
439851011774	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
439851011775	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
439851011776	alpha-glucosidase; Provisional; Region: PRK10426
439851011777	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
439851011778	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
439851011779	putative active site [active]
439851011780	putative catalytic site [active]
439851011781	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
439851011782	active site
439851011783	catalytic residues [active]
439851011784	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
439851011785	dimerization interface [polypeptide binding]; other site
439851011786	putative active cleft [active]
439851011787	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
439851011788	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
439851011789	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439851011790	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851011791	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
439851011792	substrate binding site [chemical binding]; other site
439851011793	ATP binding site [chemical binding]; other site
439851011794	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851011795	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439851011796	putative DNA binding site [nucleotide binding]; other site
439851011797	putative Zn2+ binding site [ion binding]; other site
439851011798	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851011799	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
439851011800	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851011801	motif II; other site
439851011802	hypothetical protein; Reviewed; Region: PRK01637
439851011803	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
439851011804	putative active site [active]
439851011805	dimerization interface [polypeptide binding]; other site
439851011806	putative tRNAtyr binding site [nucleotide binding]; other site
439851011807	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851011808	Coenzyme A binding pocket [chemical binding]; other site
439851011809	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
439851011810	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851011811	non-specific DNA binding site [nucleotide binding]; other site
439851011812	salt bridge; other site
439851011813	sequence-specific DNA binding site [nucleotide binding]; other site
439851011814	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
439851011815	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
439851011816	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
439851011817	Predicted transcriptional regulator [Transcription]; Region: COG2944
439851011818	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851011819	non-specific DNA binding site [nucleotide binding]; other site
439851011820	salt bridge; other site
439851011821	sequence-specific DNA binding site [nucleotide binding]; other site
439851011822	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
439851011823	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
439851011824	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
439851011825	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
439851011826	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
439851011827	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
439851011828	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
439851011829	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
439851011830	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
439851011831	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
439851011832	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
439851011833	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851011834	non-specific DNA binding site [nucleotide binding]; other site
439851011835	salt bridge; other site
439851011836	sequence-specific DNA binding site [nucleotide binding]; other site
439851011837	Cupin domain; Region: Cupin_2; cl17218
439851011838	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
439851011839	lactaldehyde reductase; Region: lactal_redase; TIGR02638
439851011840	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
439851011841	dimer interface [polypeptide binding]; other site
439851011842	active site
439851011843	metal binding site [ion binding]; metal-binding site
439851011844	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439851011845	intersubunit interface [polypeptide binding]; other site
439851011846	active site
439851011847	Zn2+ binding site [ion binding]; other site
439851011848	L-rhamnose isomerase; Provisional; Region: PRK01076
439851011849	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
439851011850	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
439851011851	N- and C-terminal domain interface [polypeptide binding]; other site
439851011852	active site
439851011853	putative catalytic site [active]
439851011854	metal binding site [ion binding]; metal-binding site
439851011855	ATP binding site [chemical binding]; other site
439851011856	rhamnulokinase; Provisional; Region: rhaB; PRK10640
439851011857	carbohydrate binding site [chemical binding]; other site
439851011858	transcriptional activator RhaS; Provisional; Region: PRK13503
439851011859	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439851011860	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851011861	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851011862	transcriptional activator RhaR; Provisional; Region: PRK13502
439851011863	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439851011864	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851011865	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
439851011866	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
439851011867	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
439851011868	DctM-like transporters; Region: DctM; pfam06808
439851011869	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
439851011870	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
439851011871	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
439851011872	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
439851011873	superoxide dismutase; Provisional; Region: PRK10925
439851011874	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
439851011875	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
439851011876	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
439851011877	MOSC domain; Region: MOSC; pfam03473
439851011878	3-alpha domain; Region: 3-alpha; pfam03475
439851011879	SnoaL-like domain; Region: SnoaL_2; pfam12680
439851011880	two-component sensor protein; Provisional; Region: cpxA; PRK09470
439851011881	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851011882	dimerization interface [polypeptide binding]; other site
439851011883	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851011884	dimer interface [polypeptide binding]; other site
439851011885	phosphorylation site [posttranslational modification]
439851011886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851011887	ATP binding site [chemical binding]; other site
439851011888	Mg2+ binding site [ion binding]; other site
439851011889	G-X-G motif; other site
439851011890	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
439851011891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851011892	active site
439851011893	intermolecular recognition site; other site
439851011894	dimerization interface [polypeptide binding]; other site
439851011895	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851011896	DNA binding site [nucleotide binding]
439851011897	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439851011898	dimer interface [polypeptide binding]; other site
439851011899	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
439851011900	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
439851011901	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
439851011902	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
439851011903	active site
439851011904	ADP/pyrophosphate binding site [chemical binding]; other site
439851011905	dimerization interface [polypeptide binding]; other site
439851011906	allosteric effector site; other site
439851011907	fructose-1,6-bisphosphate binding site; other site
439851011908	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
439851011909	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851011910	substrate binding pocket [chemical binding]; other site
439851011911	membrane-bound complex binding site; other site
439851011912	hinge residues; other site
439851011913	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
439851011914	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
439851011915	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439851011916	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
439851011917	putative substrate binding site [chemical binding]; other site
439851011918	putative ATP binding site [chemical binding]; other site
439851011919	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
439851011920	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
439851011921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851011922	DNA-binding site [nucleotide binding]; DNA binding site
439851011923	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
439851011924	UTRA domain; Region: UTRA; pfam07702
439851011925	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
439851011926	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
439851011927	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
439851011928	putative N- and C-terminal domain interface [polypeptide binding]; other site
439851011929	putative active site [active]
439851011930	putative MgATP binding site [chemical binding]; other site
439851011931	catalytic site [active]
439851011932	metal binding site [ion binding]; metal-binding site
439851011933	putative carbohydrate binding site [chemical binding]; other site
439851011934	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
439851011935	transcriptional regulator LsrR; Provisional; Region: PRK15418
439851011936	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
439851011937	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
439851011938	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
439851011939	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
439851011940	Walker A/P-loop; other site
439851011941	ATP binding site [chemical binding]; other site
439851011942	Q-loop/lid; other site
439851011943	ABC transporter signature motif; other site
439851011944	Walker B; other site
439851011945	D-loop; other site
439851011946	H-loop/switch region; other site
439851011947	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
439851011948	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439851011949	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439851011950	TM-ABC transporter signature motif; other site
439851011951	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439851011952	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439851011953	TM-ABC transporter signature motif; other site
439851011954	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
439851011955	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
439851011956	ligand binding site [chemical binding]; other site
439851011957	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
439851011958	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
439851011959	putative active site; other site
439851011960	catalytic residue [active]
439851011961	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
439851011962	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
439851011963	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
439851011964	substrate binding site [chemical binding]; other site
439851011965	hexamer interface [polypeptide binding]; other site
439851011966	metal binding site [ion binding]; metal-binding site
439851011967	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
439851011968	triosephosphate isomerase; Provisional; Region: PRK14567
439851011969	substrate binding site [chemical binding]; other site
439851011970	dimer interface [polypeptide binding]; other site
439851011971	catalytic triad [active]
439851011972	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
439851011973	Predicted membrane protein [Function unknown]; Region: COG3152
439851011974	ferredoxin-NADP reductase; Provisional; Region: PRK10926
439851011975	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
439851011976	FAD binding pocket [chemical binding]; other site
439851011977	FAD binding motif [chemical binding]; other site
439851011978	phosphate binding motif [ion binding]; other site
439851011979	beta-alpha-beta structure motif; other site
439851011980	NAD binding pocket [chemical binding]; other site
439851011981	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
439851011982	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
439851011983	putative active site [active]
439851011984	glycerol kinase; Provisional; Region: glpK; PRK00047
439851011985	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
439851011986	N- and C-terminal domain interface [polypeptide binding]; other site
439851011987	active site
439851011988	MgATP binding site [chemical binding]; other site
439851011989	catalytic site [active]
439851011990	metal binding site [ion binding]; metal-binding site
439851011991	glycerol binding site [chemical binding]; other site
439851011992	homotetramer interface [polypeptide binding]; other site
439851011993	homodimer interface [polypeptide binding]; other site
439851011994	FBP binding site [chemical binding]; other site
439851011995	protein IIAGlc interface [polypeptide binding]; other site
439851011996	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
439851011997	amphipathic channel; other site
439851011998	Asn-Pro-Ala signature motifs; other site
439851011999	septal ring assembly protein ZapB; Provisional; Region: PRK15422
439851012000	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
439851012001	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
439851012002	UbiA prenyltransferase family; Region: UbiA; pfam01040
439851012003	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
439851012004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851012005	Walker A motif; other site
439851012006	ATP binding site [chemical binding]; other site
439851012007	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
439851012008	Walker B motif; other site
439851012009	arginine finger; other site
439851012010	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
439851012011	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
439851012012	active site
439851012013	HslU subunit interaction site [polypeptide binding]; other site
439851012014	essential cell division protein FtsN; Provisional; Region: PRK10927
439851012015	cell division protein FtsN; Provisional; Region: PRK12757
439851012016	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851012017	DNA binding site [nucleotide binding]
439851012018	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
439851012019	domain linker motif; other site
439851012020	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
439851012021	dimerization interface [polypeptide binding]; other site
439851012022	ligand binding site [chemical binding]; other site
439851012023	primosome assembly protein PriA; Validated; Region: PRK05580
439851012024	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439851012025	ATP binding site [chemical binding]; other site
439851012026	putative Mg++ binding site [ion binding]; other site
439851012027	helicase superfamily c-terminal domain; Region: HELICc; smart00490
439851012028	ATP-binding site [chemical binding]; other site
439851012029	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
439851012030	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
439851012031	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439851012032	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
439851012033	dimerization interface [polypeptide binding]; other site
439851012034	DNA binding site [nucleotide binding]
439851012035	corepressor binding sites; other site
439851012036	cystathionine gamma-synthase; Provisional; Region: PRK08045
439851012037	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
439851012038	homodimer interface [polypeptide binding]; other site
439851012039	substrate-cofactor binding pocket; other site
439851012040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851012041	catalytic residue [active]
439851012042	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
439851012043	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
439851012044	putative catalytic residues [active]
439851012045	putative nucleotide binding site [chemical binding]; other site
439851012046	putative aspartate binding site [chemical binding]; other site
439851012047	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
439851012048	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
439851012049	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
439851012050	mechanosensitive channel MscS; Provisional; Region: PRK10334
439851012051	Conserved TM helix; Region: TM_helix; pfam05552
439851012052	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851012053	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
439851012054	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
439851012055	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
439851012056	active site
439851012057	metal binding site [ion binding]; metal-binding site
439851012058	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439851012059	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
439851012060	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
439851012061	dimer interface [polypeptide binding]; other site
439851012062	active site
439851012063	glycine-pyridoxal phosphate binding site [chemical binding]; other site
439851012064	folate binding site [chemical binding]; other site
439851012065	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
439851012066	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851012067	DNA-binding site [nucleotide binding]; DNA binding site
439851012068	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851012069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851012070	homodimer interface [polypeptide binding]; other site
439851012071	catalytic residue [active]
439851012072	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
439851012073	FAD binding site [chemical binding]; other site
439851012074	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
439851012075	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
439851012076	heme binding site [chemical binding]; other site
439851012077	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
439851012078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
439851012079	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
439851012080	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
439851012081	dimer interface [polypeptide binding]; other site
439851012082	active site
439851012083	metal binding site [ion binding]; metal-binding site
439851012084	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
439851012085	active site
439851012086	intersubunit interactions; other site
439851012087	catalytic residue [active]
439851012088	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439851012089	dimerization domain swap beta strand [polypeptide binding]; other site
439851012090	regulatory protein interface [polypeptide binding]; other site
439851012091	active site
439851012092	regulatory phosphorylation site [posttranslational modification]; other site
439851012093	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
439851012094	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
439851012095	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
439851012096	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
439851012097	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851012098	active site
439851012099	phosphorylation site [posttranslational modification]
439851012100	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
439851012101	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
439851012102	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
439851012103	active site
439851012104	P-loop; other site
439851012105	phosphorylation site [posttranslational modification]
439851012106	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
439851012107	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
439851012108	dimer interface [polypeptide binding]; other site
439851012109	active site
439851012110	glycine loop; other site
439851012111	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851012112	FeS/SAM binding site; other site
439851012113	pyruvate formate lyase II activase; Provisional; Region: PRK10076
439851012114	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
439851012115	active site
439851012116	P-loop; other site
439851012117	phosphorylation site [posttranslational modification]
439851012118	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851012119	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851012120	hypothetical protein; Provisional; Region: PRK10649
439851012121	Sulfatase; Region: Sulfatase; pfam00884
439851012122	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
439851012123	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
439851012124	acetylornithine deacetylase; Provisional; Region: PRK05111
439851012125	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
439851012126	metal binding site [ion binding]; metal-binding site
439851012127	putative dimer interface [polypeptide binding]; other site
439851012128	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
439851012129	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
439851012130	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
439851012131	nucleotide binding site [chemical binding]; other site
439851012132	N-acetyl-L-glutamate binding site [chemical binding]; other site
439851012133	argininosuccinate lyase; Provisional; Region: PRK04833
439851012134	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
439851012135	active sites [active]
439851012136	tetramer interface [polypeptide binding]; other site
439851012137	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
439851012138	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851012139	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
439851012140	dimerization interface [polypeptide binding]; other site
439851012141	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
439851012142	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439851012143	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439851012144	hypothetical protein; Provisional; Region: PRK11056
439851012145	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
439851012146	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
439851012147	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851012148	S-adenosylmethionine binding site [chemical binding]; other site
439851012149	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
439851012150	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439851012151	N-terminal plug; other site
439851012152	ligand-binding site [chemical binding]; other site
439851012153	glutamate racemase; Provisional; Region: PRK00865
439851012154	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
439851012155	FAD binding domain; Region: FAD_binding_4; pfam01565
439851012156	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
439851012157	Biotin operon repressor [Transcription]; Region: BirA; COG1654
439851012158	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
439851012159	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
439851012160	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
439851012161	pantothenate kinase; Provisional; Region: PRK05439
439851012162	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
439851012163	ATP-binding site [chemical binding]; other site
439851012164	CoA-binding site [chemical binding]; other site
439851012165	Mg2+-binding site [ion binding]; other site
439851012166	elongation factor Tu; Reviewed; Region: PRK00049
439851012167	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
439851012168	G1 box; other site
439851012169	GEF interaction site [polypeptide binding]; other site
439851012170	GTP/Mg2+ binding site [chemical binding]; other site
439851012171	Switch I region; other site
439851012172	G2 box; other site
439851012173	G3 box; other site
439851012174	Switch II region; other site
439851012175	G4 box; other site
439851012176	G5 box; other site
439851012177	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
439851012178	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
439851012179	Antibiotic Binding Site [chemical binding]; other site
439851012180	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
439851012181	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
439851012182	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
439851012183	putative homodimer interface [polypeptide binding]; other site
439851012184	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
439851012185	heterodimer interface [polypeptide binding]; other site
439851012186	homodimer interface [polypeptide binding]; other site
439851012187	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
439851012188	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
439851012189	23S rRNA interface [nucleotide binding]; other site
439851012190	L7/L12 interface [polypeptide binding]; other site
439851012191	putative thiostrepton binding site; other site
439851012192	L25 interface [polypeptide binding]; other site
439851012193	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
439851012194	mRNA/rRNA interface [nucleotide binding]; other site
439851012195	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
439851012196	23S rRNA interface [nucleotide binding]; other site
439851012197	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
439851012198	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
439851012199	core dimer interface [polypeptide binding]; other site
439851012200	peripheral dimer interface [polypeptide binding]; other site
439851012201	L10 interface [polypeptide binding]; other site
439851012202	L11 interface [polypeptide binding]; other site
439851012203	putative EF-Tu interaction site [polypeptide binding]; other site
439851012204	putative EF-G interaction site [polypeptide binding]; other site
439851012205	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
439851012206	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
439851012207	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
439851012208	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
439851012209	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
439851012210	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
439851012211	RPB3 interaction site [polypeptide binding]; other site
439851012212	RPB1 interaction site [polypeptide binding]; other site
439851012213	RPB11 interaction site [polypeptide binding]; other site
439851012214	RPB10 interaction site [polypeptide binding]; other site
439851012215	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
439851012216	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
439851012217	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
439851012218	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
439851012219	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
439851012220	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
439851012221	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
439851012222	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
439851012223	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
439851012224	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
439851012225	DNA binding site [nucleotide binding]
439851012226	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
439851012227	type III secretion system protein; Provisional; Region: PRK15384
439851012228	non-LEE encoded effector protein NleB; Provisional; Region: PRK15382
439851012229	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
439851012230	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851012231	FeS/SAM binding site; other site
439851012232	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
439851012233	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
439851012234	ThiS interaction site; other site
439851012235	putative active site [active]
439851012236	tetramer interface [polypeptide binding]; other site
439851012237	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
439851012238	thiS-thiF/thiG interaction site; other site
439851012239	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
439851012240	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
439851012241	ATP binding site [chemical binding]; other site
439851012242	substrate interface [chemical binding]; other site
439851012243	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
439851012244	thiamine phosphate binding site [chemical binding]; other site
439851012245	active site
439851012246	pyrophosphate binding site [ion binding]; other site
439851012247	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
439851012248	ThiC-associated domain; Region: ThiC-associated; pfam13667
439851012249	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
439851012250	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
439851012251	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
439851012252	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
439851012253	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
439851012254	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
439851012255	putative NADH binding site [chemical binding]; other site
439851012256	putative active site [active]
439851012257	nudix motif; other site
439851012258	putative metal binding site [ion binding]; other site
439851012259	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
439851012260	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
439851012261	substrate binding site [chemical binding]; other site
439851012262	active site
439851012263	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
439851012264	Active_site [active]
439851012265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
439851012266	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439851012267	IHF dimer interface [polypeptide binding]; other site
439851012268	IHF - DNA interface [nucleotide binding]; other site
439851012269	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
439851012270	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439851012271	dimer interface [polypeptide binding]; other site
439851012272	sensor protein ZraS; Provisional; Region: PRK10364
439851012273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851012274	dimer interface [polypeptide binding]; other site
439851012275	phosphorylation site [posttranslational modification]
439851012276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851012277	ATP binding site [chemical binding]; other site
439851012278	Mg2+ binding site [ion binding]; other site
439851012279	G-X-G motif; other site
439851012280	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
439851012281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851012282	active site
439851012283	phosphorylation site [posttranslational modification]
439851012284	intermolecular recognition site; other site
439851012285	dimerization interface [polypeptide binding]; other site
439851012286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851012287	Walker A motif; other site
439851012288	ATP binding site [chemical binding]; other site
439851012289	Walker B motif; other site
439851012290	arginine finger; other site
439851012291	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439851012292	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
439851012293	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
439851012294	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
439851012295	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
439851012296	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
439851012297	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
439851012298	purine monophosphate binding site [chemical binding]; other site
439851012299	dimer interface [polypeptide binding]; other site
439851012300	putative catalytic residues [active]
439851012301	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
439851012302	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
439851012303	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851012304	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
439851012305	Coenzyme A binding pocket [chemical binding]; other site
439851012306	homoserine O-succinyltransferase; Provisional; Region: PRK05368
439851012307	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
439851012308	proposed active site lysine [active]
439851012309	conserved cys residue [active]
439851012310	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
439851012311	malate synthase A; Region: malate_syn_A; TIGR01344
439851012312	active site
439851012313	isocitrate lyase; Provisional; Region: PRK15063
439851012314	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
439851012315	tetramer interface [polypeptide binding]; other site
439851012316	active site
439851012317	Mg2+/Mn2+ binding site [ion binding]; other site
439851012318	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
439851012319	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
439851012320	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
439851012321	transcriptional repressor IclR; Provisional; Region: PRK11569
439851012322	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439851012323	Bacterial transcriptional regulator; Region: IclR; pfam01614
439851012324	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
439851012325	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
439851012326	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
439851012327	substrate binding pocket [chemical binding]; other site
439851012328	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
439851012329	B12 binding site [chemical binding]; other site
439851012330	cobalt ligand [ion binding]; other site
439851012331	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
439851012332	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
439851012333	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
439851012334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
439851012335	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
439851012336	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439851012337	RNA binding surface [nucleotide binding]; other site
439851012338	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
439851012339	probable active site [active]
439851012340	hypothetical protein; Provisional; Region: PRK10515
439851012341	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439851012342	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439851012343	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851012344	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
439851012345	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851012346	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
439851012347	active site
439851012348	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
439851012349	phosphate binding site [ion binding]; other site
439851012350	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439851012351	Mor transcription activator family; Region: Mor; pfam08765
439851012352	aspartate kinase III; Validated; Region: PRK09084
439851012353	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
439851012354	nucleotide binding site [chemical binding]; other site
439851012355	substrate binding site [chemical binding]; other site
439851012356	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
439851012357	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
439851012358	dimer interface [polypeptide binding]; other site
439851012359	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
439851012360	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
439851012361	active site
439851012362	dimer interface [polypeptide binding]; other site
439851012363	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
439851012364	dimer interface [polypeptide binding]; other site
439851012365	active site
439851012366	Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106
439851012367	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
439851012368	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
439851012369	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
439851012370	Predicted membrane protein [Function unknown]; Region: COG3223
439851012371	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
439851012372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851012373	dimer interface [polypeptide binding]; other site
439851012374	conserved gate region; other site
439851012375	putative PBP binding loops; other site
439851012376	ABC-ATPase subunit interface; other site
439851012377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439851012378	dimer interface [polypeptide binding]; other site
439851012379	conserved gate region; other site
439851012380	putative PBP binding loops; other site
439851012381	ABC-ATPase subunit interface; other site
439851012382	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
439851012383	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
439851012384	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
439851012385	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
439851012386	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
439851012387	Walker A/P-loop; other site
439851012388	ATP binding site [chemical binding]; other site
439851012389	Q-loop/lid; other site
439851012390	ABC transporter signature motif; other site
439851012391	Walker B; other site
439851012392	D-loop; other site
439851012393	H-loop/switch region; other site
439851012394	TOBE domain; Region: TOBE_2; pfam08402
439851012395	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
439851012396	trimer interface; other site
439851012397	sugar binding site [chemical binding]; other site
439851012398	maltose regulon periplasmic protein; Provisional; Region: PRK10564
439851012399	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
439851012400	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
439851012401	UbiA prenyltransferase family; Region: UbiA; pfam01040
439851012402	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
439851012403	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
439851012404	putative acyl-acceptor binding pocket; other site
439851012405	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
439851012406	LexA repressor; Validated; Region: PRK00215
439851012407	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
439851012408	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
439851012409	Catalytic site [active]
439851012410	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
439851012411	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
439851012412	hypothetical protein; Provisional; Region: PRK10428
439851012413	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
439851012414	metal binding site 2 [ion binding]; metal-binding site
439851012415	putative DNA binding helix; other site
439851012416	metal binding site 1 [ion binding]; metal-binding site
439851012417	dimer interface [polypeptide binding]; other site
439851012418	structural Zn2+ binding site [ion binding]; other site
439851012419	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
439851012420	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
439851012421	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
439851012422	FMN binding site [chemical binding]; other site
439851012423	active site
439851012424	catalytic residues [active]
439851012425	substrate binding site [chemical binding]; other site
439851012426	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
439851012427	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
439851012428	NADP binding site [chemical binding]; other site
439851012429	dimer interface [polypeptide binding]; other site
439851012430	replicative DNA helicase; Provisional; Region: PRK08006
439851012431	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
439851012432	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
439851012433	Walker A motif; other site
439851012434	ATP binding site [chemical binding]; other site
439851012435	Walker B motif; other site
439851012436	DNA binding loops [nucleotide binding]
439851012437	alanine racemase; Reviewed; Region: alr; PRK00053
439851012438	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
439851012439	active site
439851012440	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439851012441	substrate binding site [chemical binding]; other site
439851012442	catalytic residues [active]
439851012443	dimer interface [polypeptide binding]; other site
439851012444	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
439851012445	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439851012446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851012447	homodimer interface [polypeptide binding]; other site
439851012448	catalytic residue [active]
439851012449	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
439851012450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851012451	active site
439851012452	motif I; other site
439851012453	motif II; other site
439851012454	Uncharacterized conserved protein [Function unknown]; Region: COG0432
439851012455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
439851012456	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
439851012457	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
439851012458	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
439851012459	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
439851012460	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
439851012461	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
439851012462	dimer interface [polypeptide binding]; other site
439851012463	ssDNA binding site [nucleotide binding]; other site
439851012464	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439851012465	hypothetical protein; Validated; Region: PRK09039
439851012466	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
439851012467	Outer membrane efflux protein; Region: OEP; pfam02321
439851012468	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
439851012469	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439851012470	HlyD family secretion protein; Region: HlyD_3; pfam13437
439851012471	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012472	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012473	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012474	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012475	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012476	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851012477	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012478	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012479	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012480	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012481	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851012482	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012483	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012484	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851012485	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012486	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012487	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012488	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012489	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851012490	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012491	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012492	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851012493	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012494	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012495	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012496	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439851012497	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012498	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012499	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012500	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012501	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012502	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012503	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439851012504	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012505	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
439851012506	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012507	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012508	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439851012509	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
439851012510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439851012511	Walker A/P-loop; other site
439851012512	ATP binding site [chemical binding]; other site
439851012513	Q-loop/lid; other site
439851012514	ABC transporter signature motif; other site
439851012515	Walker B; other site
439851012516	D-loop; other site
439851012517	H-loop/switch region; other site
439851012518	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
439851012519	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439851012520	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439851012521	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
439851012522	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851012523	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
439851012524	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
439851012525	DNA binding residues [nucleotide binding]
439851012526	dimer interface [polypeptide binding]; other site
439851012527	[2Fe-2S] cluster binding site [ion binding]; other site
439851012528	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
439851012529	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
439851012530	putative C-terminal domain interface [polypeptide binding]; other site
439851012531	putative GSH binding site (G-site) [chemical binding]; other site
439851012532	putative dimer interface [polypeptide binding]; other site
439851012533	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
439851012534	putative N-terminal domain interface [polypeptide binding]; other site
439851012535	putative dimer interface [polypeptide binding]; other site
439851012536	putative substrate binding pocket (H-site) [chemical binding]; other site
439851012537	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
439851012538	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
439851012539	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
439851012540	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439851012541	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851012542	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
439851012543	putative dimerization interface [polypeptide binding]; other site
439851012544	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
439851012545	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
439851012546	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
439851012547	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
439851012548	Na binding site [ion binding]; other site
439851012549	Predicted membrane protein [Function unknown]; Region: COG3162
439851012550	acetyl-CoA synthetase; Provisional; Region: PRK00174
439851012551	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
439851012552	active site
439851012553	CoA binding site [chemical binding]; other site
439851012554	acyl-activating enzyme (AAE) consensus motif; other site
439851012555	AMP binding site [chemical binding]; other site
439851012556	acetate binding site [chemical binding]; other site
439851012557	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
439851012558	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
439851012559	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
439851012560	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
439851012561	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
439851012562	heme lyase subunit NrfE; Provisional; Region: PRK10369
439851012563	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
439851012564	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
439851012565	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
439851012566	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439851012567	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439851012568	Sel1-like repeats; Region: SEL1; smart00671
439851012569	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
439851012570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851012571	Coenzyme A binding pocket [chemical binding]; other site
439851012572	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
439851012573	dimer interface [polypeptide binding]; other site
439851012574	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
439851012575	hypothetical protein; Provisional; Region: PRK10220
439851012576	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
439851012577	PhnA protein; Region: PhnA; pfam03831
439851012578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851012579	putative substrate translocation pore; other site
439851012580	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
439851012581	sensor protein BasS/PmrB; Provisional; Region: PRK10755
439851012582	HAMP domain; Region: HAMP; pfam00672
439851012583	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851012584	dimer interface [polypeptide binding]; other site
439851012585	phosphorylation site [posttranslational modification]
439851012586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851012587	ATP binding site [chemical binding]; other site
439851012588	Mg2+ binding site [ion binding]; other site
439851012589	G-X-G motif; other site
439851012590	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
439851012591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851012592	active site
439851012593	phosphorylation site [posttranslational modification]
439851012594	intermolecular recognition site; other site
439851012595	dimerization interface [polypeptide binding]; other site
439851012596	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851012597	DNA binding site [nucleotide binding]
439851012598	arginine:agmatin antiporter; Provisional; Region: PRK10644
439851012599	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
439851012600	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851012601	arginine decarboxylase; Provisional; Region: PRK15029
439851012602	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439851012603	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439851012604	homodimer interface [polypeptide binding]; other site
439851012605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439851012606	catalytic residue [active]
439851012607	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439851012608	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
439851012609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851012610	alpha-galactosidase; Provisional; Region: PRK15076
439851012611	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
439851012612	NAD binding site [chemical binding]; other site
439851012613	sugar binding site [chemical binding]; other site
439851012614	divalent metal binding site [ion binding]; other site
439851012615	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
439851012616	dimer interface [polypeptide binding]; other site
439851012617	melibiose:sodium symporter; Provisional; Region: PRK10429
439851012618	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
439851012619	fumarate hydratase; Provisional; Region: PRK15389
439851012620	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
439851012621	Fumarase C-terminus; Region: Fumerase_C; pfam05683
439851012622	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
439851012623	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
439851012624	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
439851012625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851012626	active site
439851012627	phosphorylation site [posttranslational modification]
439851012628	intermolecular recognition site; other site
439851012629	dimerization interface [polypeptide binding]; other site
439851012630	sensory histidine kinase DcuS; Provisional; Region: PRK11086
439851012631	PAS domain; Region: PAS; smart00091
439851012632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851012633	ATP binding site [chemical binding]; other site
439851012634	Mg2+ binding site [ion binding]; other site
439851012635	G-X-G motif; other site
439851012636	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439851012637	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439851012638	putative [Fe4-S4] binding site [ion binding]; other site
439851012639	putative molybdopterin cofactor binding site [chemical binding]; other site
439851012640	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439851012641	putative molybdopterin cofactor binding site; other site
439851012642	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439851012643	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
439851012644	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
439851012645	SdiA-regulated; Region: SdiA-regulated; pfam06977
439851012646	SdiA-regulated; Region: SdiA-regulated; cd09971
439851012647	putative active site [active]
439851012648	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
439851012649	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851012650	DNA binding residues [nucleotide binding]
439851012651	dimerization interface [polypeptide binding]; other site
439851012652	AraC family transcriptional regulator; Provisional; Region: PRK15186
439851012653	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851012654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
439851012655	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851012656	Coenzyme A binding pocket [chemical binding]; other site
439851012657	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439851012658	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
439851012659	active site
439851012660	putative transcriptional regulator; Provisional; Region: PRK11640
439851012661	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439851012662	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
439851012663	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
439851012664	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
439851012665	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
439851012666	DsbD alpha interface [polypeptide binding]; other site
439851012667	catalytic residues [active]
439851012668	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
439851012669	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
439851012670	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
439851012671	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
439851012672	Aspartase; Region: Aspartase; cd01357
439851012673	active sites [active]
439851012674	tetramer interface [polypeptide binding]; other site
439851012675	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
439851012676	putative transporter; Provisional; Region: PRK11021
439851012677	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
439851012678	oligomerisation interface [polypeptide binding]; other site
439851012679	mobile loop; other site
439851012680	roof hairpin; other site
439851012681	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
439851012682	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
439851012683	ring oligomerisation interface [polypeptide binding]; other site
439851012684	ATP/Mg binding site [chemical binding]; other site
439851012685	stacking interactions; other site
439851012686	hinge regions; other site
439851012687	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
439851012688	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
439851012689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851012690	FeS/SAM binding site; other site
439851012691	elongation factor P; Validated; Region: PRK00529
439851012692	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
439851012693	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
439851012694	RNA binding site [nucleotide binding]; other site
439851012695	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
439851012696	RNA binding site [nucleotide binding]; other site
439851012697	Predicted small secreted protein [Function unknown]; Region: COG5510
439851012698	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
439851012699	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
439851012700	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
439851012701	Iron-sulfur protein interface; other site
439851012702	proximal quinone binding site [chemical binding]; other site
439851012703	C-subunit interface; other site
439851012704	distal quinone binding site; other site
439851012705	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
439851012706	D-subunit interface [polypeptide binding]; other site
439851012707	Iron-sulfur protein interface; other site
439851012708	proximal quinone binding site [chemical binding]; other site
439851012709	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
439851012710	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
439851012711	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
439851012712	L-aspartate oxidase; Provisional; Region: PRK06175
439851012713	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
439851012714	poxB regulator PoxA; Provisional; Region: PRK09350
439851012715	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
439851012716	motif 1; other site
439851012717	dimer interface [polypeptide binding]; other site
439851012718	active site
439851012719	motif 2; other site
439851012720	motif 3; other site
439851012721	inner membrane transporter YjeM; Provisional; Region: PRK15238
439851012722	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
439851012723	putative mechanosensitive channel protein; Provisional; Region: PRK10929
439851012724	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
439851012725	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439851012726	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
439851012727	GTPase RsgA; Reviewed; Region: PRK12288
439851012728	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
439851012729	RNA binding site [nucleotide binding]; other site
439851012730	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
439851012731	GTPase/Zn-binding domain interface [polypeptide binding]; other site
439851012732	GTP/Mg2+ binding site [chemical binding]; other site
439851012733	G4 box; other site
439851012734	G5 box; other site
439851012735	G1 box; other site
439851012736	Switch I region; other site
439851012737	G2 box; other site
439851012738	G3 box; other site
439851012739	Switch II region; other site
439851012740	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
439851012741	catalytic site [active]
439851012742	putative active site [active]
439851012743	putative substrate binding site [chemical binding]; other site
439851012744	dimer interface [polypeptide binding]; other site
439851012745	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
439851012746	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439851012747	substrate binding pocket [chemical binding]; other site
439851012748	membrane-bound complex binding site; other site
439851012749	hinge residues; other site
439851012750	epoxyqueuosine reductase; Region: TIGR00276
439851012751	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
439851012752	putative carbohydrate kinase; Provisional; Region: PRK10565
439851012753	Uncharacterized conserved protein [Function unknown]; Region: COG0062
439851012754	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
439851012755	putative substrate binding site [chemical binding]; other site
439851012756	putative ATP binding site [chemical binding]; other site
439851012757	ADP-binding protein; Provisional; Region: PRK10646
439851012758	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
439851012759	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
439851012760	active site
439851012761	metal binding site [ion binding]; metal-binding site
439851012762	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
439851012763	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851012764	ATP binding site [chemical binding]; other site
439851012765	Mg2+ binding site [ion binding]; other site
439851012766	G-X-G motif; other site
439851012767	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
439851012768	ATP binding site [chemical binding]; other site
439851012769	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
439851012770	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
439851012771	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
439851012772	bacterial Hfq-like; Region: Hfq; cd01716
439851012773	hexamer interface [polypeptide binding]; other site
439851012774	Sm1 motif; other site
439851012775	RNA binding site [nucleotide binding]; other site
439851012776	Sm2 motif; other site
439851012777	GTPase HflX; Provisional; Region: PRK11058
439851012778	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
439851012779	HflX GTPase family; Region: HflX; cd01878
439851012780	G1 box; other site
439851012781	GTP/Mg2+ binding site [chemical binding]; other site
439851012782	Switch I region; other site
439851012783	G2 box; other site
439851012784	G3 box; other site
439851012785	Switch II region; other site
439851012786	G4 box; other site
439851012787	G5 box; other site
439851012788	FtsH protease regulator HflK; Provisional; Region: PRK10930
439851012789	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
439851012790	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
439851012791	FtsH protease regulator HflC; Provisional; Region: PRK11029
439851012792	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
439851012793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
439851012794	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
439851012795	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
439851012796	GDP-binding site [chemical binding]; other site
439851012797	ACT binding site; other site
439851012798	IMP binding site; other site
439851012799	transcriptional repressor NsrR; Provisional; Region: PRK11014
439851012800	Predicted transcriptional regulator [Transcription]; Region: COG1959
439851012801	exoribonuclease R; Provisional; Region: PRK11642
439851012802	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
439851012803	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
439851012804	RNB domain; Region: RNB; pfam00773
439851012805	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
439851012806	RNA binding site [nucleotide binding]; other site
439851012807	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
439851012808	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
439851012809	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
439851012810	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
439851012811	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
439851012812	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
439851012813	Predicted membrane protein [Function unknown]; Region: COG3766
439851012814	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
439851012815	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
439851012816	Predicted integral membrane protein [Function unknown]; Region: COG5463
439851012817	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
439851012818	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
439851012819	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
439851012820	FAD binding site [chemical binding]; other site
439851012821	substrate binding site [chemical binding]; other site
439851012822	catalytic residues [active]
439851012823	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851012824	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
439851012825	esterase; Provisional; Region: PRK10566
439851012826	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
439851012827	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
439851012828	transcriptional repressor UlaR; Provisional; Region: PRK13509
439851012829	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439851012830	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439851012831	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
439851012832	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
439851012833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
439851012834	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
439851012835	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851012836	active site
439851012837	phosphorylation site [posttranslational modification]
439851012838	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
439851012839	active site
439851012840	dimer interface [polypeptide binding]; other site
439851012841	magnesium binding site [ion binding]; other site
439851012842	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
439851012843	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
439851012844	AP (apurinic/apyrimidinic) site pocket; other site
439851012845	DNA interaction; other site
439851012846	Metal-binding active site; metal-binding site
439851012847	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
439851012848	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439851012849	intersubunit interface [polypeptide binding]; other site
439851012850	active site
439851012851	Zn2+ binding site [ion binding]; other site
439851012852	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439851012853	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
439851012854	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
439851012855	dimer interface [polypeptide binding]; other site
439851012856	ssDNA binding site [nucleotide binding]; other site
439851012857	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439851012858	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
439851012859	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
439851012860	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
439851012861	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
439851012862	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
439851012863	EamA-like transporter family; Region: EamA; pfam00892
439851012864	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
439851012865	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
439851012866	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
439851012867	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
439851012868	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439851012869	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
439851012870	DKNYY family; Region: DKNYY; pfam13644
439851012871	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
439851012872	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
439851012873	Hemerythrin-like domain; Region: Hr-like; cd12108
439851012874	Fe binding site [ion binding]; other site
439851012875	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
439851012876	EamA-like transporter family; Region: EamA; pfam00892
439851012877	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
439851012878	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
439851012879	NADP binding site [chemical binding]; other site
439851012880	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
439851012881	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
439851012882	active site
439851012883	metal binding site [ion binding]; metal-binding site
439851012884	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439851012885	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
439851012886	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
439851012887	active site
439851012888	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
439851012889	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
439851012890	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
439851012891	Domain of unknown function DUF21; Region: DUF21; pfam01595
439851012892	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439851012893	Transporter associated domain; Region: CorC_HlyC; smart01091
439851012894	methionine sulfoxide reductase A; Provisional; Region: PRK00058
439851012895	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
439851012896	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439851012897	Surface antigen; Region: Bac_surface_Ag; pfam01103
439851012898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
439851012899	Family of unknown function (DUF490); Region: DUF490; pfam04357
439851012900	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
439851012901	putative active site pocket [active]
439851012902	dimerization interface [polypeptide binding]; other site
439851012903	putative catalytic residue [active]
439851012904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851012905	D-galactonate transporter; Region: 2A0114; TIGR00893
439851012906	putative substrate translocation pore; other site
439851012907	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
439851012908	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
439851012909	active site
439851012910	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
439851012911	dimer interface [polypeptide binding]; other site
439851012912	substrate binding site [chemical binding]; other site
439851012913	metal binding sites [ion binding]; metal-binding site
439851012914	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
439851012915	AMP binding site [chemical binding]; other site
439851012916	metal binding site [ion binding]; metal-binding site
439851012917	active site
439851012918	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
439851012919	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439851012920	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439851012921	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439851012922	hypothetical protein; Provisional; Region: PRK05255
439851012923	peptidase PmbA; Provisional; Region: PRK11040
439851012924	cytochrome b562; Provisional; Region: PRK15058
439851012925	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
439851012926	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
439851012927	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
439851012928	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
439851012929	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
439851012930	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
439851012931	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
439851012932	active site
439851012933	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
439851012934	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
439851012935	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
439851012936	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
439851012937	HTH domain; Region: HTH_11; pfam08279
439851012938	Mga helix-turn-helix domain; Region: Mga; pfam05043
439851012939	PRD domain; Region: PRD; pfam00874
439851012940	PRD domain; Region: PRD; pfam00874
439851012941	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
439851012942	active site
439851012943	P-loop; other site
439851012944	phosphorylation site [posttranslational modification]
439851012945	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439851012946	active site
439851012947	phosphorylation site [posttranslational modification]
439851012948	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
439851012949	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
439851012950	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
439851012951	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851012952	FeS/SAM binding site; other site
439851012953	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
439851012954	ATP cone domain; Region: ATP-cone; pfam03477
439851012955	Class III ribonucleotide reductase; Region: RNR_III; cd01675
439851012956	effector binding site; other site
439851012957	active site
439851012958	Zn binding site [ion binding]; other site
439851012959	glycine loop; other site
439851012960	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
439851012961	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
439851012962	Ca binding site [ion binding]; other site
439851012963	active site
439851012964	catalytic site [active]
439851012965	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
439851012966	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
439851012967	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439851012968	active site turn [active]
439851012969	phosphorylation site [posttranslational modification]
439851012970	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439851012971	trehalose repressor; Provisional; Region: treR; PRK09492
439851012972	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851012973	DNA binding site [nucleotide binding]
439851012974	domain linker motif; other site
439851012975	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
439851012976	dimerization interface [polypeptide binding]; other site
439851012977	ligand binding site [chemical binding]; other site
439851012978	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
439851012979	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
439851012980	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439851012981	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
439851012982	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
439851012983	Soluble P-type ATPase [General function prediction only]; Region: COG4087
439851012984	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
439851012985	Transposase; Region: HTH_Tnp_1; cl17663
439851012986	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
439851012987	homotrimer interaction site [polypeptide binding]; other site
439851012988	putative active site [active]
439851012989	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
439851012990	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
439851012991	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
439851012992	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
439851012993	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
439851012994	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
439851012995	Arginine repressor [Transcription]; Region: ArgR; COG1438
439851012996	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
439851012997	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
439851012998	Predicted membrane protein [Function unknown]; Region: COG1288
439851012999	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
439851013000	ornithine carbamoyltransferase; Validated; Region: PRK02102
439851013001	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
439851013002	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
439851013003	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
439851013004	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
439851013005	putative substrate binding site [chemical binding]; other site
439851013006	nucleotide binding site [chemical binding]; other site
439851013007	nucleotide binding site [chemical binding]; other site
439851013008	homodimer interface [polypeptide binding]; other site
439851013009	arginine deiminase; Provisional; Region: PRK01388
439851013010	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
439851013011	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
439851013012	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
439851013013	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
439851013014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
439851013015	RNase E inhibitor protein; Provisional; Region: PRK11191
439851013016	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
439851013017	active site
439851013018	dinuclear metal binding site [ion binding]; other site
439851013019	dimerization interface [polypeptide binding]; other site
439851013020	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
439851013021	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
439851013022	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851013023	Coenzyme A binding pocket [chemical binding]; other site
439851013024	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
439851013025	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
439851013026	HIGH motif; other site
439851013027	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
439851013028	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
439851013029	active site
439851013030	KMSKS motif; other site
439851013031	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
439851013032	tRNA binding surface [nucleotide binding]; other site
439851013033	anticodon binding site; other site
439851013034	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
439851013035	DNA polymerase III subunit chi; Validated; Region: PRK05728
439851013036	multifunctional aminopeptidase A; Provisional; Region: PRK00913
439851013037	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
439851013038	interface (dimer of trimers) [polypeptide binding]; other site
439851013039	Substrate-binding/catalytic site; other site
439851013040	Zn-binding sites [ion binding]; other site
439851013041	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
439851013042	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
439851013043	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
439851013044	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
439851013045	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
439851013046	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439851013047	DNA binding site [nucleotide binding]
439851013048	domain linker motif; other site
439851013049	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
439851013050	putative dimerization interface [polypeptide binding]; other site
439851013051	putative ligand binding site [chemical binding]; other site
439851013052	gluconate transporter; Region: gntP; TIGR00791
439851013053	fructuronate transporter; Provisional; Region: PRK10034; cl15264
439851013054	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
439851013055	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
439851013056	NADP binding site [chemical binding]; other site
439851013057	homodimer interface [polypeptide binding]; other site
439851013058	active site
439851013059	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
439851013060	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
439851013061	putative NAD(P) binding site [chemical binding]; other site
439851013062	catalytic Zn binding site [ion binding]; other site
439851013063	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
439851013064	ATP-binding site [chemical binding]; other site
439851013065	Gluconate-6-phosphate binding site [chemical binding]; other site
439851013066	Shikimate kinase; Region: SKI; pfam01202
439851013067	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
439851013068	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
439851013069	putative NAD(P) binding site [chemical binding]; other site
439851013070	putative substrate binding site [chemical binding]; other site
439851013071	catalytic Zn binding site [ion binding]; other site
439851013072	structural Zn binding site [ion binding]; other site
439851013073	dimer interface [polypeptide binding]; other site
439851013074	Predicted transcriptional regulator [Transcription]; Region: COG3905
439851013075	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
439851013076	CcdB protein; Region: CcdB; pfam01845
439851013077	fimbrial protein SefA; Provisional; Region: PRK15228
439851013078	putative fimbrial chaperone protein SefB; Provisional; Region: PRK15233
439851013079	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851013080	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851013081	outer membrane fimbrial usher protein SefC; Provisional; Region: PRK15235
439851013082	PapC N-terminal domain; Region: PapC_N; pfam13954
439851013083	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851013084	PapC C-terminal domain; Region: PapC_C; pfam13953
439851013085	fimbrial adhesin protein SefD; Provisional; Region: PRK15231
439851013086	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439851013087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851013088	FaeA-like protein; Region: FaeA; pfam04703
439851013089	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851013090	DNA binding residues [nucleotide binding]
439851013091	dimerization interface [polypeptide binding]; other site
439851013092	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
439851013093	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439851013094	catalytic residues [active]
439851013095	hinge region; other site
439851013096	alpha helical domain; other site
439851013097	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439851013098	DNA-binding interface [nucleotide binding]; DNA binding site
439851013099	hypothetical protein; Provisional; Region: PRK12378
439851013100	Methyltransferase domain; Region: Methyltransf_23; pfam13489
439851013101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851013102	S-adenosylmethionine binding site [chemical binding]; other site
439851013103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851013104	S-adenosylmethionine binding site [chemical binding]; other site
439851013105	hypothetical protein; Provisional; Region: PRK13687
439851013106	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
439851013107	Uncharacterized conserved protein [Function unknown]; Region: COG3439
439851013108	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
439851013109	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
439851013110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439851013111	DNA-binding site [nucleotide binding]; DNA binding site
439851013112	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439851013113	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
439851013114	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
439851013115	active site
439851013116	HIGH motif; other site
439851013117	dimer interface [polypeptide binding]; other site
439851013118	KMSKS motif; other site
439851013119	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
439851013120	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
439851013121	aspartate racemase; Region: asp_race; TIGR00035
439851013122	cell density-dependent motility repressor; Provisional; Region: PRK10082
439851013123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439851013124	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439851013125	dimerization interface [polypeptide binding]; other site
439851013126	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
439851013127	isoaspartyl dipeptidase; Provisional; Region: PRK10657
439851013128	dimer interface [polypeptide binding]; other site
439851013129	active site
439851013130	hypothetical protein; Provisional; Region: PRK10519
439851013131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
439851013132	Nucleoside recognition; Region: Gate; pfam07670
439851013133	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
439851013134	Predicted membrane protein [Function unknown]; Region: COG2733
439851013135	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
439851013136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439851013137	putative substrate translocation pore; other site
439851013138	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
439851013139	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
439851013140	NAD(P) binding site [chemical binding]; other site
439851013141	catalytic residues [active]
439851013142	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
439851013143	Protein of unknown function DUF91; Region: DUF91; cl00709
439851013144	Uncharacterized conserved protein [Function unknown]; Region: COG3586
439851013145	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
439851013146	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
439851013147	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
439851013148	HsdM N-terminal domain; Region: HsdM_N; pfam12161
439851013149	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
439851013150	Methyltransferase domain; Region: Methyltransf_26; pfam13659
439851013151	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
439851013152	Nuclease-related domain; Region: NERD; pfam08378
439851013153	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
439851013154	Family description; Region: UvrD_C_2; pfam13538
439851013155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
439851013156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
439851013157	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
439851013158	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
439851013159	P-loop, Walker A motif; other site
439851013160	Base recognition motif; other site
439851013161	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
439851013162	Uncharacterized small protein [Function unknown]; Region: COG2879
439851013163	carbon starvation protein A; Provisional; Region: PRK15015
439851013164	Carbon starvation protein CstA; Region: CstA; pfam02554
439851013165	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
439851013166	methyl-accepting protein IV; Provisional; Region: PRK09793
439851013167	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439851013168	dimer interface [polypeptide binding]; other site
439851013169	ligand binding site [chemical binding]; other site
439851013170	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439851013171	dimerization interface [polypeptide binding]; other site
439851013172	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439851013173	dimer interface [polypeptide binding]; other site
439851013174	putative CheW interface [polypeptide binding]; other site
439851013175	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
439851013176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851013177	Walker A motif; other site
439851013178	ATP binding site [chemical binding]; other site
439851013179	Walker B motif; other site
439851013180	arginine finger; other site
439851013181	Transcriptional antiterminator [Transcription]; Region: COG3933
439851013182	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439851013183	active pocket/dimerization site; other site
439851013184	active site
439851013185	phosphorylation site [posttranslational modification]
439851013186	PRD domain; Region: PRD; pfam00874
439851013187	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439851013188	active pocket/dimerization site; other site
439851013189	active site
439851013190	phosphorylation site [posttranslational modification]
439851013191	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
439851013192	active site
439851013193	phosphorylation site [posttranslational modification]
439851013194	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
439851013195	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
439851013196	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
439851013197	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
439851013198	dimer interface [polypeptide binding]; other site
439851013199	active site
439851013200	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
439851013201	dimer interface [polypeptide binding]; other site
439851013202	active site
439851013203	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
439851013204	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
439851013205	putative active site [active]
439851013206	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
439851013207	phosphoglycerol transferase I; Provisional; Region: PRK03776
439851013208	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
439851013209	hypothetical protein; Provisional; Region: PRK11667
439851013210	DNA replication protein DnaC; Validated; Region: PRK07952
439851013211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439851013212	Walker A motif; other site
439851013213	ATP binding site [chemical binding]; other site
439851013214	Walker B motif; other site
439851013215	primosomal protein DnaI; Provisional; Region: PRK02854
439851013216	hypothetical protein; Provisional; Region: PRK09917
439851013217	Uncharacterized conserved protein [Function unknown]; Region: COG2966
439851013218	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
439851013219	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
439851013220	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439851013221	DNA binding residues [nucleotide binding]
439851013222	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
439851013223	putative deacylase active site [active]
439851013224	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
439851013225	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
439851013226	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
439851013227	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439851013228	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439851013229	metal binding site [ion binding]; metal-binding site
439851013230	active site
439851013231	I-site; other site
439851013232	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
439851013233	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
439851013234	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
439851013235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439851013236	S-adenosylmethionine binding site [chemical binding]; other site
439851013237	DNA polymerase III subunit psi; Validated; Region: PRK06856
439851013238	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439851013239	Coenzyme A binding pocket [chemical binding]; other site
439851013240	dUMP phosphatase; Provisional; Region: PRK09449
439851013241	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851013242	motif II; other site
439851013243	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
439851013244	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
439851013245	G1 box; other site
439851013246	putative GEF interaction site [polypeptide binding]; other site
439851013247	GTP/Mg2+ binding site [chemical binding]; other site
439851013248	Switch I region; other site
439851013249	G2 box; other site
439851013250	G3 box; other site
439851013251	Switch II region; other site
439851013252	G4 box; other site
439851013253	G5 box; other site
439851013254	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
439851013255	periplasmic protein; Provisional; Region: PRK10568
439851013256	BON domain; Region: BON; pfam04972
439851013257	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
439851013258	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
439851013259	active site
439851013260	nucleophile elbow; other site
439851013261	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
439851013262	active site
439851013263	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
439851013264	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439851013265	FeS/SAM binding site; other site
439851013266	hypothetical protein; Provisional; Region: PRK10977
439851013267	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
439851013268	intersubunit interface [polypeptide binding]; other site
439851013269	active site
439851013270	catalytic residue [active]
439851013271	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
439851013272	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
439851013273	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
439851013274	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
439851013275	phosphopentomutase; Provisional; Region: PRK05362
439851013276	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
439851013277	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
439851013278	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
439851013279	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
439851013280	HipA-like C-terminal domain; Region: HipA_C; pfam07804
439851013281	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
439851013282	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
439851013283	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
439851013284	hypothetical protein; Provisional; Region: PRK11246
439851013285	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
439851013286	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439851013287	motif II; other site
439851013288	DNA repair protein RadA; Region: sms; TIGR00416
439851013289	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
439851013290	Walker A motif/ATP binding site; other site
439851013291	ATP binding site [chemical binding]; other site
439851013292	Walker B motif; other site
439851013293	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
439851013294	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439851013295	non-specific DNA binding site [nucleotide binding]; other site
439851013296	salt bridge; other site
439851013297	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
439851013298	sequence-specific DNA binding site [nucleotide binding]; other site
439851013299	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
439851013300	active site
439851013301	(T/H)XGH motif; other site
439851013302	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
439851013303	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
439851013304	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851013305	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851013306	ABC transporter; Region: ABC_tran_2; pfam12848
439851013307	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439851013308	lytic murein transglycosylase; Provisional; Region: PRK11619
439851013309	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439851013310	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439851013311	catalytic residue [active]
439851013312	Trp operon repressor; Provisional; Region: PRK01381
439851013313	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
439851013314	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439851013315	catalytic core [active]
439851013316	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
439851013317	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439851013318	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
439851013319	hypothetical protein; Provisional; Region: PRK10756
439851013320	CreA protein; Region: CreA; pfam05981
439851013321	DNA-binding response regulator CreB; Provisional; Region: PRK11083
439851013322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851013323	active site
439851013324	phosphorylation site [posttranslational modification]
439851013325	intermolecular recognition site; other site
439851013326	dimerization interface [polypeptide binding]; other site
439851013327	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851013328	DNA binding site [nucleotide binding]
439851013329	sensory histidine kinase CreC; Provisional; Region: PRK11100
439851013330	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
439851013331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439851013332	dimer interface [polypeptide binding]; other site
439851013333	phosphorylation site [posttranslational modification]
439851013334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439851013335	ATP binding site [chemical binding]; other site
439851013336	Mg2+ binding site [ion binding]; other site
439851013337	G-X-G motif; other site
439851013338	putative major fimbrial protein SthE; Provisional; Region: PRK15292
439851013339	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439851013340	putative fimbrial protein SthD; Provisional; Region: PRK15293
439851013341	putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294
439851013342	PapC N-terminal domain; Region: PapC_N; pfam13954
439851013343	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439851013344	PapC C-terminal domain; Region: PapC_C; pfam13953
439851013345	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
439851013346	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439851013347	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439851013348	putative fimbrial protein SthA; Provisional; Region: PRK15296
439851013349	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
439851013350	Helix-turn-helix domain; Region: HTH_36; pfam13730
439851013351	two-component response regulator; Provisional; Region: PRK11173
439851013352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439851013353	active site
439851013354	phosphorylation site [posttranslational modification]
439851013355	intermolecular recognition site; other site
439851013356	dimerization interface [polypeptide binding]; other site
439851013357	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439851013358	DNA binding site [nucleotide binding]
439851013359	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
439851013360	putative RNA methyltransferase; Provisional; Region: PRK10433